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class="vector-toc-link" href="#Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Adding sections to Retroperitoneal Fibrosis (RF sometimes referred to as IRPF)</span> </div> </a> <span class="ext-discussiontools-init-sidebar-meta">3 comments</span> <ul id="toc-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-IgG4" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#IgG4"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>IgG4</span> </div> </a> <span class="ext-discussiontools-init-sidebar-meta">1 comment</span> <ul id="toc-IgG4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-endometriosis" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" 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src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/12px-WHO_Rod.svg.png" decoding="async" width="12" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/18px-WHO_Rod.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/WHO_Rod.svg/24px-WHO_Rod.svg.png 2x" data-file-width="107" data-file-height="250"/></span></span></span><span class="portalbox-link"><a href="/wiki/Portal:Medicine" title="Portal:Medicine">Medicine portal</a></span></li></ul>This article is within the scope of <b><a href="/wiki/Wikipedia:WikiProject_Medicine" title="Wikipedia:WikiProject Medicine">WikiProject Medicine</a></b>, which recommends that medicine-related articles follow the <a href="/wiki/Wikipedia:Manual_of_Style/Medicine-related_articles" title="Wikipedia:Manual of Style/Medicine-related articles">Manual of Style for medicine-related articles</a> and that biomedical information in any article <a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)">use high-quality medical sources</a>. Please visit the project page for details or ask questions at <i><a href="/wiki/Wikipedia_talk:WikiProject_Medicine" title="Wikipedia talk:WikiProject Medicine">Wikipedia talk:WikiProject Medicine</a></i>.<span class="metadata wpb-metadata"><span class="wpb-project">Medicine</span><span class="wpb-project_link">Wikipedia:WikiProject Medicine</span><span class="wpb-banner_name">Template:WikiProject Medicine</span><span class="wpb-assessment_cat">medicine articles</span></span></td><td class="mbox-empty-cell"></td></tr><tr><td class="assess import-mid"><a href="/wiki/Category:Mid-importance_medicine_articles" title="Category:Mid-importance medicine articles">Mid</a></td><td class="mbox-text" colspan="2">This article has been rated as <b>Mid-importance</b> on the <a href="/wiki/Wikipedia:WikiProject_Medicine/Assessment#Importance_scale" title="Wikipedia:WikiProject Medicine/Assessment">project's importance scale</a>.</td></tr><tr><td></td><td class="mbox-text" colspan="2">This article is supported by <b><a href="/wiki/Wikipedia:WikiProject_Medicine/Pathology_task_force" title="Wikipedia:WikiProject Medicine/Pathology task force">the Pathology task force</a></b> (assessed as <a href="/wiki/Category:Mid-importance_pathology_articles" title="Category:Mid-importance pathology articles">Mid-importance</a>).</td></tr></tbody></table></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1237879475"><table class="plainlinks tmbox tmbox-notice" role="presentation"><tbody><tr><td class="mbox-image"><span typeof="mw:File"><a href="/wiki/File:Library.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Library.svg/60px-Library.svg.png" decoding="async" width="60" height="62" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Library.svg/90px-Library.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Library.svg/120px-Library.svg.png 2x" data-file-width="732" data-file-height="758"/></a></span></td><td class="mbox-text"><b>Ideal sources</b> for Wikipedia's health content are defined in the guideline <i><a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)">Wikipedia:Identifying reliable sources (medicine)</a></i> and are typically <a href="/wiki/Review_article" title="Review article">review articles</a>. Here are links to <b>possibly useful</b> sources of information about <b>Retroperitoneal fibrosis</b>.<br/> <ul><li><a href="/wiki/PubMed" title="PubMed">PubMed</a> provides <b><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed?term=%28+%22Retroperitoneal+fibrosis%22+%29+AND+Review%5Bptyp%5D+AND+%22last+5+years%22%5BPDat%5D">review articles from the past five years</a></b> (limit to <b><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed?term=%28+%22Retroperitoneal+fibrosis%22+%29+AND+Review%5Bptyp%5D+AND+free+full+text%5Bsb%5D+AND+%22last+5+years%22%5BPDat%5D">free review articles</a></b>)</li> <li>The <a href="/wiki/Trip_(search_engine)" title="Trip (search engine)">TRIP database</a> provides <b><a rel="nofollow" class="external text" href="https://www.tripdatabase.com/search?categoryid=1,11,16,18,10,9,4&criteria=%22Retroperitoneal+fibrosis%22">clinical publications about evidence-based medicine</a></b>.</li> <li>Other potential sources include: <b><a rel="nofollow" class="external text" href="https://www.crd.york.ac.uk/CRDWeb/">Centre for Reviews and Dissemination</a></b> and <b><a rel="nofollow" class="external text" href="https://search.cdc.gov/search?query=Retroperitoneal+fibrosis&affiliate=cdc-main">CDC</a></b></li></ul></td></tr></tbody></table> <meta property="mw:PageProp/toc"/> <div class="mw-heading mw-heading2 ext-discussiontools-init-section"><h2 id="How" data-mw-thread-id="h-How-2006-01-25T00:08:00.000Z"><span data-mw-comment-start="" id="h-How-2006-01-25T00:08:00.000Z"></span>How<span data-mw-comment-end="h-How-2006-01-25T00:08:00.000Z"></span></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Talk:Retroperitoneal_fibrosis&action=edit&section=1" title="Edit section: How"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span><div class="ext-discussiontools-init-section-bar"><div class="ext-discussiontools-init-section-metadata"></div><div class="ext-discussiontools-init-section-actions"></div></div></div> <p><span data-mw-comment-start="" id="c-Jfdwolff-2006-01-25T00:08:00.000Z-How"></span>How was I supposed to know that the Lancet were going to publish a seminar on this 2 days after its creation? I'll update the page as necessary. <a href="/wiki/User:Jfdwolff" title="User:Jfdwolff">JFW</a> | <a href="/wiki/User_talk:Jfdwolff" title="User talk:Jfdwolff"><small>T@lk</small></a> <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-Jfdwolff-2006-01-25T00:08:00.000Z-How" class="ext-discussiontools-init-timestamplink">00:08, 25 January 2006 (UTC)</a><span class="ext-discussiontools-init-replylink-buttons" data-mw-thread-id="c-Jfdwolff-2006-01-25T00:08:00.000Z-How"><span class="ext-discussiontools-init-replylink-bracket">[</span><a class="ext-discussiontools-init-replylink-reply" role="button" tabindex="0" href="">reply</a><span class="ext-discussiontools-init-replylink-bracket">]</span></span><span data-mw-comment-end="c-Jfdwolff-2006-01-25T00:08:00.000Z-How"></span> </p> <div class="mw-heading mw-heading2 ext-discussiontools-init-section"><h2 id="Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)" data-mw-thread-id="h-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)-2010-04-09T02:37:00.000Z"><span id="Adding_sections_to_Retroperitoneal_Fibrosis_.28RF_sometimes_referred_to_as_IRPF.29"></span><span data-mw-comment-start="" id="h-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)-2010-04-09T02:37:00.000Z"></span>Adding sections to Retroperitoneal Fibrosis (RF sometimes referred to as IRPF)<span data-mw-comment-end="h-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)-2010-04-09T02:37:00.000Z"></span></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Talk:Retroperitoneal_fibrosis&action=edit&section=2" title="Edit section: Adding sections to Retroperitoneal Fibrosis (RF sometimes referred to as IRPF)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span><div class="ext-discussiontools-init-section-bar"><div class="ext-discussiontools-init-section-metadata"></div><div class="ext-discussiontools-init-section-actions"></div></div></div> <p><span data-mw-comment-start="" id="c-98.23.50.223-2012-03-08T07:17:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span>1st suggested addition: There are a few online support groups for those with Retroperitoneal Fibrosis and caregivers <a rel="nofollow" class="external free" href="https://groups.io/g/RetroperitonealFibrosis">https://groups.io/g/RetroperitonealFibrosis</a> with about 300 members; has extensive collection of articles, papers, videos, links. There are archives of messages posted since 2001.<span style="font-size: smaller;" class="autosigned">— Preceding <a href="/wiki/Wikipedia:Signatures" title="Wikipedia:Signatures">unsigned</a> comment added by <a href="/wiki/Special:Contributions/98.23.50.223" title="Special:Contributions/98.23.50.223">98.23.50.223</a> (<a href="/w/index.php?title=User_talk:98.23.50.223&action=edit&redlink=1" class="new" title="User talk:98.23.50.223 (page does not exist)">talk</a>) <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-98.23.50.223-2012-03-08T07:17:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)" class="ext-discussiontools-init-timestamplink">07:17, 8 March 2012 (UTC)</a></span><span class="ext-discussiontools-init-replylink-buttons" data-mw-thread-id="c-98.23.50.223-2012-03-08T07:17:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"><span class="ext-discussiontools-init-replylink-bracket">[</span><a class="ext-discussiontools-init-replylink-reply" role="button" tabindex="0" href="">reply</a><span class="ext-discussiontools-init-replylink-bracket">]</span></span><span data-mw-comment-end="c-98.23.50.223-2012-03-08T07:17:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span> </p><p><span data-mw-comment-start="" id="c-32.210.12.47-2021-02-06T23:38:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span>Add external link to <a rel="nofollow" class="external free" href="http://retroperitonealfibrosis.com/">http://retroperitonealfibrosis.com/</a> </p><p>2nd suggested addition: What's next for the patient? "Proper" care for a patient with Retroperitoneal Fibrosis has not been proven by published trial results. (There has only been one randomized, double blind study, to compare prednisone vs tamoxifen. That study showed tamoxifen to be less effective than prednisone at reducing the RF mass.) However, there are a few standard protocols used by most practitioners with experience in the treatment. </p><p>Retroperitoneal Fibrosis is an extremely rare disease and most doctors never see an actual patient. Therefore it is up to the RF patient and/or their caregivers to make sure the proper care is given so as to minimize damage to kidney function. Expert RF aware centers are Guys in London, Mayo in USA. </p><p>Possible treatments: Will be up to your Dr to explain. Steroids, imuran, cellcept, or rituximab infusion - which seems to work best on IgG4+RF - and/or surgery (stents are considered surgery) are options. Usual treatment is preds at high dose (average is 60 mg/day) for about three months followed by slowly weaning and gradually increasing one of the three drugs mentioned above. These meds are used to reduce the RF mass from around the aorta and/or ureters. </p><p>If ureterolysis surgery is done, a complete/entire omental wrapping of the ureter is used to protect against Retroperitoneal fibrotic tissue re-growing & again attaching & encasing ureters (& other organs/structures) is important,particularly where less than a full wrap was undertaken. If there is not adequate omentum be aware of alternate "wrap material" eg. perinephric fat or other fat from within the abdomen. </p><p>If treatment doesn't work: Ask your Dr to check for IgG4+RF which may require an surgical biopsy (needle biopsy usually does not capture sufficient tissue for biopsy) if blood test for IgG4 is inconclusive (60-70 % of IgG4+RF does not show positive in blood work). IgG4+RF usually responds to rituximab infusions.--<a href="/wiki/Special:Contributions/32.210.12.47" title="Special:Contributions/32.210.12.47">32.210.12.47</a> (<a href="/w/index.php?title=User_talk:32.210.12.47&action=edit&redlink=1" class="new" title="User talk:32.210.12.47 (page does not exist)">talk</a>) <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-32.210.12.47-2021-02-06T23:38:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)" class="ext-discussiontools-init-timestamplink">23:38, 6 February 2021 (UTC)</a><span class="ext-discussiontools-init-replylink-buttons" data-mw-thread-id="c-32.210.12.47-2021-02-06T23:38:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"><span class="ext-discussiontools-init-replylink-bracket">[</span><a class="ext-discussiontools-init-replylink-reply" role="button" tabindex="0" href="">reply</a><span class="ext-discussiontools-init-replylink-bracket">]</span></span><span data-mw-comment-end="c-32.210.12.47-2021-02-06T23:38:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span> </p><p><span data-mw-comment-start="" id="c-Pmorgan7-2010-04-09T02:37:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span>Suggested by Putnam Morgan, Connecticut, USA 2.6.2021--<a href="/w/index.php?title=User:Pmorgan7&action=edit&redlink=1" class="new" title="User:Pmorgan7 (page does not exist)">Pmorgan7</a> (<a href="/wiki/User_talk:Pmorgan7" title="User talk:Pmorgan7">talk</a>) <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-Pmorgan7-2010-04-09T02:37:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)" class="ext-discussiontools-init-timestamplink">02:37, 9 April 2010 (UTC)</a><span class="ext-discussiontools-init-replylink-buttons" data-mw-thread-id="c-Pmorgan7-2010-04-09T02:37:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"><span class="ext-discussiontools-init-replylink-bracket">[</span><a class="ext-discussiontools-init-replylink-reply" role="button" tabindex="0" href="">reply</a><span class="ext-discussiontools-init-replylink-bracket">]</span></span><span data-mw-comment-end="c-Pmorgan7-2010-04-09T02:37:00.000Z-Adding_sections_to_Retroperitoneal_Fibrosis_(RF_sometimes_referred_to_as_IRPF)"></span> </p> <div class="mw-heading mw-heading2 ext-discussiontools-init-section"><h2 id="IgG4" data-mw-thread-id="h-IgG4-2011-06-20T13:46:00.000Z"><span data-mw-comment-start="" id="h-IgG4-2011-06-20T13:46:00.000Z"></span>IgG4<span data-mw-comment-end="h-IgG4-2011-06-20T13:46:00.000Z"></span></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Talk:Retroperitoneal_fibrosis&action=edit&section=3" title="Edit section: IgG4"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span><div class="ext-discussiontools-init-section-bar"><div class="ext-discussiontools-init-section-metadata"></div><div class="ext-discussiontools-init-section-actions"></div></div></div> <p><span data-mw-comment-start="" id="c-Jfdwolff-2011-06-20T13:46:00.000Z-IgG4"></span><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FBOR.0b013e3283412f7c">10.1097/BOR.0b013e3283412f7c</a> <a href="/wiki/IgG4" class="mw-redirect" title="IgG4">IgG4</a> deposition seems to be an important mechanism. <a href="/wiki/User:Jfdwolff" title="User:Jfdwolff">JFW</a> | <a href="/wiki/User_talk:Jfdwolff" title="User talk:Jfdwolff"><small>T@lk</small></a> <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-Jfdwolff-2011-06-20T13:46:00.000Z-IgG4" class="ext-discussiontools-init-timestamplink">13:46, 20 June 2011 (UTC)</a><span class="ext-discussiontools-init-replylink-buttons" data-mw-thread-id="c-Jfdwolff-2011-06-20T13:46:00.000Z-IgG4"><span class="ext-discussiontools-init-replylink-bracket">[</span><a class="ext-discussiontools-init-replylink-reply" role="button" tabindex="0" href="">reply</a><span class="ext-discussiontools-init-replylink-bracket">]</span></span><span data-mw-comment-end="c-Jfdwolff-2011-06-20T13:46:00.000Z-IgG4"></span> </p> <div class="mw-heading mw-heading2 ext-discussiontools-init-section"><h2 id="endometriosis" data-mw-thread-id="h-endometriosis-20240410200900"><span data-mw-comment-start="" id="h-endometriosis-20240410200900"></span>endometriosis<span data-mw-comment-end="h-endometriosis-20240410200900"></span></h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Talk:Retroperitoneal_fibrosis&action=edit&section=4" title="Edit section: endometriosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span><div class="ext-discussiontools-init-section-bar"><div class="ext-discussiontools-init-section-metadata"></div><div class="ext-discussiontools-init-section-actions"></div></div></div> <p><span data-mw-comment-start="" id="c-68.199.114.39-20240410200900-endometriosis"></span>It is recognized that endometriosis can lead to retroperitoneal fibrosis. <a href="/wiki/Special:Contributions/68.199.114.39" title="Special:Contributions/68.199.114.39">68.199.114.39</a> (<a href="/w/index.php?title=User_talk:68.199.114.39&action=edit&redlink=1" class="new" title="User talk:68.199.114.39 (page does not exist)">talk</a>) <a href="https://en.wikipedia.org/wiki/Talk:Retroperitoneal_fibrosis#c-68.199.114.39-20240410200900-endometriosis" 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