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class="search-overlay"> <form method="GET" action="https://msresearch.nl" class="search-form"> <label> <input type="search" name="s" class="search-input" placeholder="Zoeken …" autofocus="autofocus"> </label> <button type="submit"><span class="icon-search"></span></button> <span class="icon-cross"></span> </form> </div> </div> </nav> </div> </div> </header> <div id="readspeaker-content">  <style> @media all and (max-width: 980px) { #section-heading .bgimage { background-image: url(https://msresearch.nl/app/uploads/2024/01/campagne-januari-2024-mobile.jpg); background-position: 50% 50% !important; } } @media all and (min-width: 981px) { #section-heading .bgimage { background-image: url(https://msresearch.nl/app/uploads/2024/01/campagne-januari-2024-1024x793.jpg); background-position: 50% 50% !important; } } </style> <section id="section-heading" class="section no-padding"> <div class="bgimage"></div> <div class="container"> <div class="content"> <div class="inner"> <h1 style="text-align: left;">Voor een toekomst zonder MS</h1> <p style="text-align: left;">Maar liefst 1 op de 500 mensen in Nederland heeft MS. Onze stichting financiert en stimuleert wetenschappelijk onderzoek naar de oorzaak en oplossing van MS. Elke bijdrage helpt vooruitgang te boeken.</p> <div class="desktop-cta ctas"> <div class="main-cta"> <a href="https://msresearch.nl/donatie-ms-research/" target="_self" class="btn"> Doneer nu </a> </div> <div class="text-link"> <a href="" target=""> </a> </div> </div> </div> </div> <div class="mobile-cta ctas"> <div class="main-cta"> <a href="https://msresearch.nl/donatie-ms-research/" target="_self" class="btn"> Doneer nu </a> </div> <div class="text-link"> <a href="" target=""> </a> </div> </div> </div> </section> <section id="section-content-image" class="section "> <span id="section-anchor-3" class="anchor"></span> <div class="container"> <div id="inner-container" class="one-fourth"> <div class="text content"> <h2>Doe jij mee met The May 50K?</h2> <p><img decoding="async" alt="" width="162" height="223" data-srcset="https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-218x300.jpg 218w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-743x1024.jpg 743w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-768x1059.jpg 768w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-240x331.jpg 240w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-360x496.jpg 360w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-480x662.jpg 480w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-720x993.jpg 720w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt.jpg 800w" data-src="https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-218x300.jpg" data-sizes="(max-width: 162px) 100vw, 162px" class="alignleft wp-image-16723 lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img decoding="async" class="alignleft wp-image-16723" src="https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-218x300.jpg" alt="" width="162" height="223" srcset="https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-218x300.jpg 218w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-743x1024.jpg 743w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-768x1059.jpg 768w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-240x331.jpg 240w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-360x496.jpg 360w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-480x662.jpg 480w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt-720x993.jpg 720w, https://msresearch.nl/app/uploads/2025/04/Stichting-MS-Research_Tommy_May50Kshirt.jpg 800w" sizes="(max-width: 162px) 100vw, 162px" /></noscript></p> <p class="p1">Maak kennis met MS-onderzoeker Tommy Broeders. Dit jaar doet hij voor de derde keer mee aan The May 50K. Zijn doel is om maar liefst 100 kilometer af te leggen in de maand mei. Wil jij, net als Tommy, minstens 50 kilometer bewegen? Meld je dan aan!</p> <p>Of je nu rent, huppelt, wandelt, zwemt of schaatst: elke stap die je zet brengt ons dichterbij het vinden van de oplossing voor MS.</p> <p><a href="https://www.themay50k.nl">Ja, ik meld me aan!聽 >></a></p> </div> </div> </div> </section> <section id="section-news" class="section"> <span id="section-anchor-4" class="anchor"></span> <div class="container"> <div class="section-title"> <h2>Nieuws</h2> </div> <div id="inner-container"> <div class="most-recent"> <article class="news-item" style="background-image: url(https://msresearch.nl/app/uploads/2025/04/Marieke-3-768x512.jpg)"> <a href="https://msresearch.nl/nieuws/ms-gerelateerde-vermoeidheid/" class="overlay"></a> <div class="content"> <div class="date"> 08 april 2025 </div> <h2>Resultaten onderzoek MS-gerelateerde vermoeidheid</h2> </div> </article> </div><div class="items"> <article class="news-item" style="background-image: url(https://msresearch.nl/app/uploads/2025/04/250331-MS.nl_-768x366.png)"> <a href="https://msresearch.nl/nieuws/jaarmsnl/" class="overlay"></a> <div class="content"> <div class="date"> 01 april 2025 </div> <h2>1 jaar MS.nl</h2> </div> </article> <article class="news-item" style="background-image: url(https://msresearch.nl/app/uploads/2025/03/300125PegV2-scaled-e1742467324776-768x555.jpg)"> <a href="https://msresearch.nl/nieuws/valentina-tnf/" class="overlay"></a> <div class="content"> <div class="date"> 27 maart 2025 </div> <h2>Op weg naar effectieve behandelingen voor MS</h2> </div> </article> </div> </div> <div class="overview-link"> <a href="https://msresearch.nl/nieuws/"> Alle nieuwsberichten bekijken </a> </div> </div> </section> <section id="section-linkblocks" class="section three-blocks"> <span id="section-anchor-5" class="anchor"></span> <div class="container"> <div id="linkblocks"> <div class="linkblock"> <div class="inner-linkblock"> <a href="https://msresearch.nl/over-ms-ziekte/" target="_self" class="overlay"></a> <div class="image"> <img alt="" data-src="https://msresearch.nl/app/uploads/2020/07/Group-96.png" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw=="><noscript><img src="https://msresearch.nl/app/uploads/2020/07/Group-96.png" alt=""></noscript> </div> <div class="content"> <h3>Alles over MS</h3> <span class="subtitle">Lees meer over de mechanismen en oorzaken van de ziekte</span> </div> </div> </div> <div class="linkblock"> <div class="inner-linkblock"> <a href="https://msresearch.nl/help-mee/" target="_self" class="overlay"></a> <div class="image"> <img alt="" data-src="https://msresearch.nl/app/uploads/2020/08/hartje-1.png" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw=="><noscript><img src="https://msresearch.nl/app/uploads/2020/08/hartje-1.png" alt=""></noscript> </div> <div class="content"> <h3>Onderzoek helpt MS de wereld uit!</h3> <span class="subtitle">Helpt u mee?</span> </div> </div> </div> <div class="linkblock"> <div class="inner-linkblock"> <a href="https://msresearch.nl/ms-onderzoek/successen-onderzoek/" target="_self" class="overlay"></a> <div class="image"> <img alt="" data-src="https://msresearch.nl/app/uploads/2020/07/Group-97.png" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw=="><noscript><img src="https://msresearch.nl/app/uploads/2020/07/Group-97.png" alt=""></noscript> </div> <div class="content"> <h3>Belangrijke resultaten</h3> <span class="subtitle">Lees meer over onderzoeksresultaten in MS-onderzoek</span> </div> </div> </div> </div> </div> </section> <section id="section-boxedcontent" class="section no-padding"> <span id="section-anchor-6" class="anchor"></span> <div class="container content"> <h3><strong>Lees ons magazine Rondom MS聽</strong></h3> <p><img decoding="async" alt="" width="158" height="224" data-srcset="https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-212x300.png 212w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-723x1024.png 723w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-768x1088.png 768w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-1084x1536.png 1084w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-240x340.png 240w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-360x510.png 360w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-480x680.png 480w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-720x1020.png 720w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68.png 1208w" data-src="https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-212x300.png" data-sizes="(max-width: 158px) 100vw, 158px" class="wp-image-14458 alignright lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img decoding="async" class="wp-image-14458 alignright" src="https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-212x300.png" alt="" width="158" height="224" srcset="https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-212x300.png 212w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-723x1024.png 723w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-768x1088.png 768w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-1084x1536.png 1084w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-240x340.png 240w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-360x510.png 360w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-480x680.png 480w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68-720x1020.png 720w, https://msresearch.nl/app/uploads/2024/05/Rondom-MS-68.png 1208w" sizes="(max-width: 158px) 100vw, 158px" /></noscript></p> <p>Ons magazine Rondom MS verschijnt minstens eens per jaar en staat in het teken van MS en MS-onderzoek. De laatste editie heeft als thema <em>Diagnose</em>.</p> <p>Benieuwd? 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De microglia zijn de afweercellen van het centrale zenuwstelsel.","Laesie":"een gebied in het centrale zenuwstelsel dat is aangedaan door MS. In MS betekent dit een gebied waarin de myeline is verminderd of verdwenen en waar vaak een litteken is ontstaan.","RRMS":"Relapsing Remitting MS: Een aanvalsgewijze vorm van MS waarbij perioden met uitvalsverschijnselen zich afwisselen met perioden van herstel.","CIS":"Clinical Isolated Syndrome: De diagnose CIS wordt gesteld bij mensen die voor de eerste keer symptomen hebben gehad die wijzen op een hoog risico voor het ontwikkelen van MS.","Actieve MS":"Een vorm van MS waarbij er sprake is van frequente aanvallen en\/of actieve laesies op de MRI-scan en\/of toename van aantal laesies op MRI-scan.","PPMS":"primair progressieve MS: Een vorm van MS waarbij er vanaf de diagnose sprake is van een geleidelijke achteruitgang zonder periodes van herstel.","PET":"Een PET-scan (Positron Emissie Tomografie) is een neuroimaging techniek. Een PET-scan maakt kleurige afbeeldingen van hersenactiviteit na het inspuiten van kleine hoeveelheden radioactieve markeerstoffen, een zogenaamde tracer. Welke weefsels \u2018oplichten\u2019 in de scan is afhankelijk van de gebruikte tracer. Dit kan een markeerstof voor bijvoorbeeld myeline zijn.","iPS-cellen":"iPS cellen (induced pluripotent stem cells) zijn cellen die volgens een bepaalde strikte procedure opnieuw geprogrammeerd worden. Hierdoor lijken de cellen erg op embryonale stamcellen. Deze cellen kunnen zich vermenigvuldigen en uitgroeien tot elk celtype in ons lichaam. Onderzoekers spreken van MSiPS cellen wanneer de stamcellen voor herprogrammering afkomstig zijn van mensen met MS.","ziekte onderdrukkende medicijnen":"In het Engels spreekt men over disease modifying therapy (DMT).","Glia cellen":"Glia cellen zijn de niet-zenuwcellen van het centrale zenuwstelsel: astrocyten, microglia en oligodendrocyten.","Cytokines":"Een groep stoffen waarmee cellen van het afweersysteem onderling en met andere cellen communiceren. Verschillende soorten cytokines kunnen afweercellen en hiermee dus ook ontstekingen activeren of juist remmen.","Ocrelizumab":"Ocrelizumab (Ocrevus) is het eerste medicijn dat \u2013 zij het in beperkte mate - effectief is als behandeling voor progressieve MS. Het middel wordt ook gebruikt als behandeling voor agressieve RR MS. Het medicijn zorgt dat het immuunsysteem wordt aangepast door een bepaald type witte bloedcellen, de zogenaamde B-cellen, uit het lichaam te verwijderen.","MRI":"staat voor magnetic resonance imaging. Met deze scantechniek kunnen organen en weefsels in het lichaam in beeld worden gebracht. MRI maakt gebruik van een sterk magnetisch veld en radiogolven. Een MRI-scan is pijnloos en stelt mensen niet bloot aan straling. De scan laat zien op welke plaatsen in het centrale zenuwstelsel er schade of ontstekingen zijn. MRI-scans worden gebruikt om de diagnose MS te stellen en het ziekteverloop te monitoren. ","OCT":"Optical Coherence Tomography is een methode om structuren in het oog, zoals het netvlies en de oogzenuw, in beeld te brengen. OCT lijkt op echografie, maar maakt gebruik van licht in plaats van geluidsgolven. Met een OCT-scan kunnen afwijkingen in de binnenste lagen van het netvlies worden vastgesteld. De afwijkingen in het netvlies kunnen mogelijk een graadmeter vormen voor zenuwschade bij MS. ","RJ650":"De RJ650 richtlijn is een richtlijn voor de jaarverslaggeving van fondsenwervende organisaties.","pati\u00ebntgebonden klinisch onderzoek":"Pati\u00ebntgebonden klinisch onderzoek richt zich op vraagstellingen die vanuit het ziekzijn worden gegenereerd, ongeacht of het gericht is op preventie, behandeling of zorg. Dit gebeurt door (nieuwe) geneesmiddelen, combinaties van geneesmiddelen, therapie\u00ebn of medische hulpmiddelen te testen bij pati\u00ebnten en\/of gezonde vrijwilligers onder goed gecontroleerde condities.","myeline":"de isolatielaag rond zenuwbanen in het centrale zenuwstelsel. Myeline zorgt ervoor dat signalen snel worden doorgegeven en voorkomt dat een signaal overspringt naar een andere zenuwcel. Bij MS raakt de isolatielaag beschadigd en worden signalen niet meer goed doorgegeven.","biomarkers":"wordt gebruikt in de gezondheidszorg en in het onderzoek om het functioneren van een orgaan of een ziekteproces aan te geven. Het is meestal een stof of cel die je kunt meten in bijvoorbeeld het bloed of hersenvloeistof. Biomarkers kunnen informatie geven over de aanwezigheid, de vorm, de activiteit en\/of het verloop van een ziekte. ","bloed-hersenbarri\u00e8re":"De bloed-hersenbarri\u00e8re is een aaneengesloten rij van cellen en eiwitten tussen het bloed en het centrale zenuwstelsel. Deze barri\u00e8re vormt een natuurlijke grens om de hersenen te beschermen tegen bijv. schadelijke stoffen en ziekteverwekkers in het bloed. Bij MS ontstaan \u2018lekken\u2019 in de bloed-hersenbarri\u00e8re en kunnen schadelijke afweercellen uit het bloed de hersenen binnendringen.","centrale zenuwstelsel":"de hersenen en het ruggenmerg.","multidisciplinaire screening":"Een pati\u00ebnt wordt afhankelijk van zijn\/haar hulpvraag door verschillende behandeldisciplines onderzocht op basis van dit onderzoek volgt een gezamenlijk (behandel)advies. MS-expertisecentrum Nieuw Unicum biedt deze dienst aan voor mensen met MS.","neurodegeneratie":"het afsterven van zenuwcellen in het centrale zenuwstelsel of de verbindingen tussen deze zenuwcellen. Zenuwschade zorgt voor een geleidelijk verlies van lichamelijke en\/of cognitieve functies die kenmerkend zijn voor de ziekteprogressie bij MS. ","oligodendrocyt":"(letterlijk: cel met enkele uitlopers of vertakkingen). Oligodendrocyten zijn de hersencellen die myeline produceren in het centrale zenuwstelsel. De cellen wikkelen zich rondom zenuwbanen en vormen een myelineschede. Dankzij deze isolatielaag worden signalen snel doorgegeven. ","schub":"een periode waarin nieuwe MS-klachten ontstaan of bestaande klachten sterk toenemen. Men spreekt van een schub als deze klachten langer dan 24 uur aanhouden. Een schub wordt ook wel \u2018exacerbatie\u2019 of \u2018relapse\u2019 genoemd. ","Remyelinisatie":"Het herstel van myeline om zenuwbanen waarvan de myelineschede eerder verdwenen of aangetast is. ","Oligodendrocyten":"Oligodendrocyten zijn de hersencellen die myeline produceren in het centrale zenuwstelsel. De cellen wikkelen zich rondom zenuwbanen en vormen een myelineschede. Dankzij deze isolatielaag worden signalen snel doorgegeven. ","MS-laesie":"Een gebied aangedaan door MS. In een MS-laesie is de myeline rondom zenuwbanen verdwenen of aangetast. Vaak is er een litteken ontstaan. Wanneer er in het gebied ontstekingscellen aanwezig zijn spreekt men van een actieve laesie. ","Corticale laesies":"Een van de gevolgen van MS is dat gebieden in de hersenschors worden aangetast. Deze plekken heten corticale laesies.","DIR":"Double Inversion Recovery: een geavanceerde MRI-scan waarmee bepaalde MS-laesies (een gebied dat is aangedaan door MS) beter zichtbaar zijn.","PSIR":"Phase Sensitive Inversion Recovery: een geavanceerde MRI-scan waarmee bepaalde MS-laesies (een gebied dat is aangedaan door MS) beter zichtbaar zijn.","ISGylation":"ISGylation is \u00e9\u00e9n van de regelmechanismes die plaatsvinden in cellen. Bij ISGylation wordt een bepaalde \u2018code\u2019 op eiwitten geplakt. Door deze \u2018code\u2019 komen de eiwitten onder andere op een andere plek in de cel terecht en dat heeft weer invloed op hoe de een cel zich gedraagt.","extracellulaire matrix":"Extracellulaire matrix is de biologische naam voor het steunweefsel dat de cellen in weefsels omgeeft. De matrix wordt gevormd door langgerekte eiwitten en geeft het weefsel stevigheid en structuur. De structuur en samenstelling van de matrix is aangepast op het type weefsel. Zo heeft botweefsel bijvoorbeeld een extra stevige matrix. Het steunweefsel bevat ook verschillende signaalstoffen. Cellen die aanwezig zijn in het steunweefsel, reageren op deze signalen. Zo be\u00efnvloedt de samenstelling van het steunweefsel het functioneren van cellen.","gerandomiseerd":"Gerandomiseerd betekent dat willekeurig (\u201cat random\u201d) door middel van loting wordt bepaald in welke behandelingsgroep je wordt ingedeeld.","immuunreactie":"Reactie van het immuunsysteem om zich te verdedigen tegen ziekteverwekkers die aanwezig zijn in het lichaam.","GlialCAM":"Een stofje op de buitenkant van glia cellen (een type hersencellen). ","Moleculaire mimicry":"Er zijn structuren tussen ziekteverwekker en gastheer die erg op elkaar lijken, waardoor het immuunsysteem structuren van het eigen lichaam verward met die van een ziekteverwekker en het eigen lichaam gaat aanvallen.","Antivirale middelen":"Medicijnen die gebruikt worden om een virus te bestrijden.","Valaciclovir":"Een medicijn dat wordt voorgeschreven bij bepaalde virus infecties.","Rituximab":"Een medicijn dat B-cellen verwijdert.","Anti-CD20 medicijn":"Een medicijn die bindt aan CD20, een stofje op de buitenkant van B-cellen. Dit medicijn kan B-cellen verwijderen of hun werking stoppen. Voorbeelden van anti-CD20 medicijnen zijn: rituximab, ocrelizumab, ofatumumab en ublituximab.","Ependymcellen":"Endotheelcellen van de hersenkamers en het centrale kanaal van het ruggenmerg. De ependymcellen zijn van de familie van de neuroglia, bevatten trilharen en vormen neurogliavezels. De ependymale cellen vormen de begrenzing van het centrale wervelkanaal en de vier ventrikels. Ook produceren ze het hersenvocht (liquor cerebrospinalis).","MOG-ziekte":"MOGAD (MOG antistof geassocieerde ziekte) is een recent ontdekte zeldzame neuro-inflammatoire ziekte die ontstekingen in de oogzenuwen, maar soms ook in de hersenen, hersenstam en het ruggenmerg veroorzaakt. Zowel kinderen als volwassenen kunnen MOGAD ontwikkelen.","CTRAM":"Class I-restricted T cell-associated molecule. Een oppervlakte molecuul op cytotoxische T-cellen en NK-cellen. De functie van dit molecuul is nog onbekend, maar in dit onderzoek lijkt dit molecuul een rol te spelen bij MS.","neuronale stamcellen":"Neuronale stamcellen zijn de voorlopers van alle verschillende soorten hersencellen, zoals zenuwcellen en gliacellen.","Genexpressie profiel":"Genen zijn de bouwstenen waaruit het DNA bestaat. Dat DNA zit in (bijna) elke cel in je lichaam. Echter, niet al je genen zijn in \u00e9lke cel actief. Immers, in de cellen in het puntje van je neus hoeven er geen genen actief te zijn die te maken hebben met het verteren van eten. Die moeten juist in de cellen in je darmen actief zijn. Dat is wat het genexpressieprofiel aangeeft: welke genen op een bepaalde plek in je lichaam daadwerkelijk actief zijn.","Type-I interferon":"Type I-interferon behoren tot de interferonen-familie. Het zijn natuurlijke eiwitten, die worden uitgescheiden door ge\u00efnfecteerde cellen. Ze spelen een belangrijke rol bij de werking van het immuunsysteem. Er zijn veel verschillende soorten interferonen die in het menselijk lichaam voorkomen. Deze verschillende soorten interferon zijn belangrijk bij het controleren en verwijderen van acute en chronische infecties en hebben allen een eigen taak en functie. Daarnaast is de hoeveelheid en de locatie van IFN essentieel voor de uiteindelijke effecten en gevolgen in het lichaam (beschermend dan wel schadelijk).","default-mode netwerk":"Het default-mode netwerk (DMN) is de natuurlijke staat van ons brein. Het is een netwerk van verschillende hersengebieden dat juist actief wordt in rust, of beter gezegd: als we niet met volle focus met iets bezig zijn. Ons brein schakelt dan automatisch over op deze dwaalmodus.","Astrocyten":"Dit zijn steuncellen in de hersenen die ervoor zorgen dat de reparatie van de myelinelaag goed verloopt. 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