Speaking of Medicine and Health - The PLOS medical journals’ blog

<!doctype html> <html lang="en-US"> <head> <meta charset="utf-8"> <meta http-equiv="x-ua-compatible" content="ie=edge"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <script> const tracking = null; </script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>Speaking of Medicine and Health - The PLOS medical journals’ blog</title> <meta name="description" content="The PLOS medical journals’ blog" /> <link rel="canonical" href="https://speakingofmedicine.plos.org/" /> <link rel="next" href="https://speakingofmedicine.plos.org/page/2/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="website" /> <meta property="og:title" content="Speaking of Medicine and Health" /> <meta property="og:description" content="The PLOS medical journals’ blog" /> <meta property="og:url" content="https://speakingofmedicine.plos.org/" /> <meta property="og:site_name" content="Speaking of Medicine and Health" /> <meta name="twitter:card" content="summary_large_image" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"CollectionPage","@id":"https://speakingofmedicine.plos.org/","url":"https://speakingofmedicine.plos.org/","name":"Speaking of Medicine and Health - The PLOS medical journals’ blog","isPartOf":{"@id":"https://speakingofmedicine.plos.org/#website"},"description":"The PLOS medical journals’ blog","breadcrumb":{"@id":"https://speakingofmedicine.plos.org/#breadcrumb"},"inLanguage":"en-US"},{"@type":"BreadcrumbList","@id":"https://speakingofmedicine.plos.org/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home"}]},{"@type":"WebSite","@id":"https://speakingofmedicine.plos.org/#website","url":"https://speakingofmedicine.plos.org/","name":"Speaking of Medicine and Health","description":"The PLOS medical journals’ blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://speakingofmedicine.plos.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}</script>  <link rel='dns-prefetch' href='//speakingofmedicine.plos.org' /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/speakingofmedicine.plos.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://speakingofmedicine.plos.org/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='safe-svg-svg-icon-style-inline-css' type='text/css'> .safe-svg-cover{text-align:center}.safe-svg-cover .safe-svg-inside{display:inline-block;max-width:100%}.safe-svg-cover svg{height:100%;max-height:100%;max-width:100%;width:100%} </style> <style id='co-authors-plus-coauthors-style-inline-css' type='text/css'> .wp-block-co-authors-plus-coauthors.is-layout-flow [class*=wp-block-co-authors-plus]{display:inline} </style> <style id='co-authors-plus-avatar-style-inline-css' type='text/css'> .wp-block-co-authors-plus-avatar :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-avatar :where(img){vertical-align:middle}.wp-block-co-authors-plus-avatar:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-avatar.aligncenter{display:table;margin-inline:auto} </style> <style id='co-authors-plus-image-style-inline-css' type='text/css'> .wp-block-co-authors-plus-image{margin-bottom:0}.wp-block-co-authors-plus-image :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-image :where(img){vertical-align:middle}.wp-block-co-authors-plus-image:is(.alignfull,.alignwide) :where(img){width:100%}.wp-block-co-authors-plus-image:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-image.aligncenter{display:table;margin-inline:auto} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){margin-left: auto !important;margin-right: auto !important;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='prefix-style-css' href='https://speakingofmedicine.plos.org/wp-content/plugins/orcid-master/assets/orcid.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='sage/main.css-css' href='https://speakingofmedicine.plos.org/wp-content/themes/plos/dist/styles/main_2eafddd7.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-content/themes/plos/resources/lib/scripts/jquery-3.5.1.min.js?ver=3.5.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-content/plugins/orcid-master/assets/orcid.js?ver=6.6.2" id="orcid-javascript-js"></script> <link rel="https://api.w.org/" href="https://speakingofmedicine.plos.org/wp-json/" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://speakingofmedicine.plos.org/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.6.2" /> <style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style> <link href="https://fonts.googleapis.com/css?family=Merriweather:400,400i,900,900i|Roboto:400,400i,600,600i&display=swap" rel="stylesheet"> <link rel="apple-touch-icon" sizes="180x180" href="https://plos.org/wp-content/themes/plos/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://plos.org/wp-content/themes/plos/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://plos.org/wp-content/themes/plos/favicon/favicon-16x16.png"> <link rel="manifest" href="https://plos.org/wp-content/themes/plos/favicon/site.webmanifest"> <link rel="mask-icon" href="https://plos.org/wp-content/themes/plos/favicon/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="https://plos.org/wp-content/themes/plos/favicon/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="https://plos.org/wp-content/themes/plos/favicon/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> <style type="text/css"> header.app-header, .archive__header, .search__header { background-color: #ffffff; color: #00156b; } header.app-header a, .app-header__search-container input[type=search].search-form__field, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--prev a, .archive__header li.pagination__item--next a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item--page a, .search__header li.pagination__item--prev a, .search__header li.pagination__item--next a, .search__header a.pagination__mobile-link { color: #00156b; } .app-header__drawer-small-title, .app-header__container:after, .app-header__drawer:after, .app-header__nav-toggle span, .app-header__nav-toggle span:before, .app-header__nav-toggle span:after, a.app-header__nav-toggle span, a.app-header__nav-toggle span:before, a.app-header__nav-toggle span:after, ul.app-header__primary-nav > li.menu-item-has-children > a:after, ul.app-header__primary-nav > li.menu-item-has-children:hover > a:after, .app-header__search-container .search-form__label:before, .app-header__search-container .search-form__label:after, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a, ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--page a:hover, .archive__header li.pagination__item--page a:focus, .search__header li.pagination__item--page a, .search__header li.pagination__item--page a:hover, .search__header li.pagination__item--page a:focus { border-color: #00156b; } ul.app-header__primary-nav > li.current-menu-item > a:before, ul.app-header__primary-nav > li.current-page-ancestor > a:before { border-color: #ffffff; } .app-header .button.button--shortcode.button--s, .search__header input[type=submit] { border-color: #00156b; background: #00156b; color: #ffffff; } .app-header .button.button--shortcode.button--s:hover, .app-header .button.button--shortcode.button--s:focus, .search__header input[type=submit]:hover, .search__header input[type=submit]:focus { background: #00156b; color: #ffffff; opacity: 0.85; } ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a { background-color: #ffffff; } .app-header__drawer a:not(.post-list__post-image), .archive__header li.pagination__item a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item a, .search__header a.pagination__mobile-link { background-image: linear-gradient(#00156b, #00156b); } .app-header__drawer a:not(.post-list__post-image):hover, .app-header__drawer a:not(.post-list__post-image):focus, .archive__header li.pagination__item a:hover, .archive__header li.pagination__item a:focus, .archive__header a.pagination__mobile-link:hover, .archive__header a.pagination__mobile-link:focus, .search__header li.pagination__item a:hover, .search__header li.pagination__item a:focus, .search__header a.pagination__mobile-link:hover, .search__header a.pagination__mobile-link:focus { color: #ffffff; background-size: 100% 100%; background-position: 0% 100%; } .archive__header li.pagination__item--page.pagination__item--current a, .search__header li.pagination__item--page.pagination__item--current a { background-color: #00156b; border-color: #00156b; color: #ffffff; } .search__header form.search-form input[type=search] { background-color: #ffffff; border-color: #00156b; color: #00156b; } </style>  <script> /*! For license information please see head.js.LICENSE.txt */ (()=>{var e={773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var o,r=(o=n(808))&&o.__esModule?o:{default:o},i=n(773);function u(e){return Object.assign({},...i.VALID_PURPOSES.map((t=>({[t]:e}))))}var a={get:function(){try{const e=JSON.parse(r.default.get(i.COOKIE_KEY));return e?!0===e?u(!0):e:u(!1)}catch(e){return u(!1)}},isSet:function(){return void 0!==r.default.get(i.COOKIE_KEY)},remove:function(){r.default.remove(i.COOKIE_KEY)},set:function(e){const t=window.location.hostname;r.default.set(i.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:i.RECONSENT_INTERVAL})}};t.default=a},177:(e,t,n)=>{"use strict";t.default=void 0;var o,r=(o=n(502))&&o.__esModule?o:{default:o},i=n(773);function u(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,r.default.get())}var a={accept:function(){r.default.set(!0),u()},customize:function(e,t){r.default.set(Object.assign(r.default.get(),{[e]:t})),u()},hasConsented:function(e){if(!i.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+i.VALID_PURPOSES.toString());return r.default.get()[e]},hasInteracted:function(){return r.default.isSet()},reject:function(){r.default.set(!1),u()},reset:function(){r.default.remove()},VALID_PURPOSES:i.VALID_PURPOSES};t.default=a},808:(e,t,n)=>{var o,r,i;void 0===(r="function"==typeof(o=i=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var o in n)t[o]=n[o]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(o){function r(){}function i(t,n,i){if("undefined"!=typeof document){"number"==typeof(i=e({path:"/"},r.defaults,i)).expires&&(i.expires=new Date(1*new Date+864e5*i.expires)),i.expires=i.expires?i.expires.toUTCString():"";try{var u=JSON.stringify(n);/^[\{\[]/.test(u)&&(n=u)}catch(e){}n=o.write?o.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var a="";for(var c in i)i[c]&&(a+="; "+c,!0!==i[c]&&(a+="="+i[c].split(";")[0]));return document.cookie=t+"="+n+a}}function u(e,n){if("undefined"!=typeof document){for(var r={},i=document.cookie?document.cookie.split("; "):[],u=0;u<i.length;u++){var a=i[u].split("="),c=a.slice(1).join("=");n||'"'!==c.charAt(0)||(c=c.slice(1,-1));try{var s=t(a[0]);if(c=(o.read||o)(c,s)||t(c),n)try{c=JSON.parse(c)}catch(e){}if(r[s]=c,e===s)break}catch(e){}}return e?r[e]:r}}return r.set=i,r.get=function(e){return u(e,!1)},r.getJSON=function(e){return u(e,!0)},r.remove=function(t,n){i(t,"",e(n,{expires:-1}))},r.defaults={},r.withConverter=n,r}((function(){}))})?o.call(t,n,t,e):o)||(e.exports=r),e.exports=i()}},t={};function n(o){var r=t[o];if(void 0!==r)return r.exports;var i=t[o]={exports:{}};return e[o](i,i.exports,n),i.exports}(()=>{"use strict";var e=n(177);window.plosCookieConsent=e.default})()})(); </script>  </head> <body class="home blog app-data index-data home-data front-page-data elementor-default elementor-kit-3349"> <a class="skip-to-content" href="#content">Skip to content</a> <div id="top"></div> <header class="app-header"> <div class="app-header__container container"> <a class="app-header__brand" href=//plos.org> <img class="app-header__logo" src="https://speakingofmedicine.plos.org/wp-content/uploads/2020/01/logo-sea.svg" alt="Speaking of Medicine and Health logo" /> </a> <nav class="app-header__nav"> <div class="app-header__nav-row"> <div class="app-header__primary-nav-container"> <div class="menu-header-navigation-container"><ul id="menu-header-navigation" class="app-header__primary-nav"><li id="menu-item-411" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-411"><a href="https://plos.org/publish/">Publish with PLOS</a> <ul class="sub-menu"> <li id="menu-item-9363" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9363"><a href="https://plos.org/your-journal-options/">Which Journal?</a></li> <li id="menu-item-1409" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1409"><a href="https://plos.org/publish/submit/">Submit</a></li> <li id="menu-item-2355" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2355"><a href="https://plos.org/publish/publishing-faqs/">Publishing FAQs</a></li> <li id="menu-item-2356" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2356"><a href="https://plos.org/publish/fees/">Fees</a></li> <li id="menu-item-2357" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2357"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-2358" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2358"><a href="https://plos.org/publish/metrics/">Metrics</a></li> <li id="menu-item-2359" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2359"><a href="https://plos.org/publish/funder-compliance/">Funder Compliance</a></li> <li id="menu-item-34242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34242"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> </ul> </li> <li id="menu-item-307" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-307"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-384" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-384"><a href="https://plos.org/open-science/">Open Science</a> <ul class="sub-menu"> <li id="menu-item-18582" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-18582"><a href="https://plos.org/open-science/open-access/">Open Access</a></li> <li id="menu-item-16399" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16399"><a href="https://plos.org/open-science/preprints/">Preprints</a></li> <li id="menu-item-17362" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17362"><a href="https://plos.org/open-science/open-data/">Open Data</a></li> <li id="menu-item-9918" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9918"><a href="https://plos.org/open-science/open-methods/">Open Methods</a></li> <li id="menu-item-7116" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7116"><a href="https://plos.org/protocols/">Protocols</a></li> <li id="menu-item-17916" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17916"><a href="https://plos.org/open-science/preregistration/">Preregistration</a></li> <li id="menu-item-17327" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-17327"><a href="https://plos.org/open-science/open-code/">Open Code</a></li> <li id="menu-item-2361" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2361"><a href="https://plos.org/published-peer-review-history/">Published Peer Review History</a></li> <li id="menu-item-16833" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16833"><a href="https://plos.org/open-science/credit/">Credit</a></li> </ul> </li> <li id="menu-item-260" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-260"><a href="https://plos.org/resources/">Resources</a> <ul class="sub-menu"> <li id="menu-item-692" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-692"><a href="https://plos.org/resources/for-institutions/">For Institutions</a></li> <li id="menu-item-5291" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5291"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-8642" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8642"><a href="https://plos.org/resources/editor-center/">Editor Center</a></li> <li id="menu-item-425" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-425"><a href="https://plos.org/resources/for-reviewers/">Peer Review Center</a></li> <li id="menu-item-16410" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16410"><a href="https://plos.org/research-by-plos/">Research by PLOS</a></li> <li id="menu-item-5004" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5004"><a href="https://plos.org/resources/writing-center/">Writing Center</a></li> </ul> </li> <li id="menu-item-420" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-420"><a href="https://plos.org/about/">About PLOS</a></li> </ul></div> </div> <div class="app-header__nav-controls"> <div class="app-header__search-container"> <form role="search" method="get" class="search-form" action="//plos.org"> <label class="search-form__label" for="s"><span class="screen-reader-text">Search:</span></label> <input type="search" class="search-form__field" value="" name="s" id="s" /> <input type="submit" class="search-form__submit" value="Search" /> </form> </div> <a class="app-header__nav-toggle" href="#"><span>Menu</span></a> </div> </div> </nav> </div> <div class="app-header__drawer"> <div class="app-header__drawer-container"> <div class="app-header__drawer-col app-header__drawer-content"> <div class="app-header__drawer-rich-text"> <p><span style="font-weight: 400;">When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.</span></p> <div class="acf-label"> <p class="description"></p> </div> </div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">Journals</span> <div class="menu-journals-container"><ul id="menu-journals" class="app-header__drawer-menu app-header__drawer-menu--1"><li id="menu-item-275" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-275"><a href="https://journals.plos.org/plosbiology/">PLOS Biology</a></li> <li id="menu-item-8531" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8531"><a href="https://journals.plos.org/climate">PLOS Climate</a></li> <li id="menu-item-31915" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31915"><a href="https://journals.plos.org/complexsystems/">PLOS Complex Systems</a></li> <li id="menu-item-276" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-276"><a href="https://journals.plos.org/ploscompbiol/">PLOS Computational Biology</a></li> <li id="menu-item-8535" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8535"><a href="https://journals.plos.org/digitalhealth">PLOS Digital Health</a></li> <li id="menu-item-277" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-277"><a href="https://journals.plos.org/plosgenetics/">PLOS Genetics</a></li> <li id="menu-item-8534" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8534"><a href="https://journals.plos.org/globalpublichealth">PLOS Global Public Health</a></li> <li id="menu-item-278" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-278"><a href="https://journals.plos.org/plosmedicine/">PLOS Medicine</a></li> <li id="menu-item-31916" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31916"><a href="https://journals.plos.org/mentalhealth/">PLOS Mental Health</a></li> <li id="menu-item-279" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-279"><a href="https://journals.plos.org/plosntds/">PLOS Neglected Tropical Diseases</a></li> <li id="menu-item-280" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-280"><a href="https://journals.plos.org/plosone/">PLOS ONE</a></li> <li id="menu-item-281" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-281"><a href="https://journals.plos.org/plospathogens/">PLOS Pathogens</a></li> <li id="menu-item-8533" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8533"><a href="https://journals.plos.org/sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li id="menu-item-8532" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8532"><a href="https://journals.plos.org/water">PLOS Water</a></li> </ul></div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">More Content</span> <div class="menu-more-content-container"><ul id="menu-more-content" class="app-header__drawer-menu app-header__drawer-menu--2"><li id="menu-item-282" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-282"><a href="https://plos.org/blogs/">PLOS Blogs</a></li> <li id="menu-item-283" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-283"><a href="https://collections.plos.org/">PLOS Collections</a></li> </ul></div> </div> </div> </div> </header> <style>.blog-header__background { background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2020/05/PLOS-Medicine-blog.jpg); }.blog-header__text { color: #ffffff }.blog-header__author-orcid { color: #ffffff }.blog-header__orcid-icon { background-color: #ffffff }</style><div class="blog-header"> <div class="blog-header__text"> <span class="blog-header__label">PLOS BLOGS</span> <a class="blog-header__blog-name" href="https://speakingofmedicine.plos.org">Speaking of Medicine and Health</a> <p class="blog-header__blog-description">Providing an informal venue for readers, authors, editors and friends of the PLOS medical journals to discuss global health topics and issues that are important to the community.</p> <div class="blog-header__background"></div> </div> <div class="blog-header__blogs-navigation blogs-navigation"> <div class="blogs-navigation__container"> <a class="blogs-navigation__mobile-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__mobile-container"> <div class="blogs-navigation__main-menu-container"> <div class="menu-blog-navigation-container"><ul id="menu-blog-navigation" class="blogs-navigation__main-menu"><li id="menu-item-2212" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2212"><a href="https://speakingofmedicine.plos.org/about-this-blog/">About This Blog</a></li> <li id="menu-item-2211" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2211"><a href="https://speakingofmedicine.plos.org/contact/">Contact</a></li> <li id="menu-item-2210" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2210"><a href="https://speakingofmedicine.plos.org/author-guidelines/">Author Guidelines</a></li> </ul></div> </div> <div class="blogs-navigation__drawer"> <a class="blogs-navigation__drawer-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__drawer-menu-container"> <div class="menu-blogs-menu-container"><ul id="menu-blogs-menu" class="blogs-navigation__drawer-menu"><li id="menu-item-3654" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-3654"><a href="#">Staff Blogs</a> <ul class="sub-menu"> <li id="menu-item-3655" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3655"><a href="https://theplosblog.plos.org">Official PLOS Blog</a></li> <li id="menu-item-3656" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3656"><a href="http://everyone.plos.org">EveryONE Blog</a></li> <li id="menu-item-9185" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9185"><a href="https://latitude.plos.org/">Latitude</a></li> <li id="menu-item-3657" class="menu-item menu-item-type-custom menu-item-object-custom current-menu-item menu-item-3657"><a href="https://speakingofmedicine.plos.org" aria-current="page">Speaking of Medicine</a></li> <li id="menu-item-3658" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3658"><a href="https://biologue.plos.org">PLOS Biologue</a></li> <li id="menu-item-3659" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3659"><a href="https://collectionsblog.plos.org/">PLOS Collections</a></li> </ul> </li> <li id="menu-item-3660" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3660"><a href="#">Independent Blogs</a> <ul class="sub-menu"> <li id="menu-item-3661" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3661"><a href="https://absolutelymaybe.plos.org">Absolutely Maybe</a></li> <li id="menu-item-3662" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3662"><a href="https://dnascience.plos.org">DNA Science</a></li> <li id="menu-item-3663" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3663"><a href="https://ecrcommunity.plos.org">PLOS ECR Community</a></li> <li id="menu-item-3664" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3664"><a href="https://scicomm.plos.org">SciComm</a></li> <li id="menu-item-3665" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3665"><a href="https://allmodels.plos.org">All Models Are Wrong</a></li> <li id="menu-item-3896" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3896"><a href="https://yoursay.plos.org">Your Say</a></li> </ul> </li> <li id="menu-item-3666" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3666"><a href="#">About</a> <ul class="sub-menu"> <li id="menu-item-3821" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3821"><a href="https://plos.org/blogs/about/">About PLOS Blogs</a></li> <li id="menu-item-3820" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3820"><a href="https://plos.org/blogs/contact/">Contact</a></li> </ul> </li> </ul></div> </div> </div> </div> </div> </div> </div> <div class="wrap" role="document"> <div class="content" id="content"> <main class="main"> <div class="archive"> <div class="archive__posts"> <form class="archive-filters archive__filters" data-permalink-base="https://speakingofmedicine.plos.org"> <fieldset> <legend>Filter Posts</legend> <div class="archive-filters__container"> <div class="archive-filters__control-container"> <label for="archive-filters__control--search">Search</label> <input type="text" id="archive-filters__control--search" data-name="search" class="archive-filters__control" /> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--date">Year</label> <select id="archive-filters__control--date" data-name="date" class="archive-filters__control"> <option value="" >All years</option> <option value="2024" >2024</option> <option value="2023" >2023</option> <option value="2022" >2022</option> <option value="2021" >2021</option> <option value="2020" >2020</option> <option value="2019" >2019</option> <option value="2018" >2018</option> <option value="2017" >2017</option> <option value="2016" >2016</option> <option value="2015" >2015</option> <option value="2014" >2014</option> <option value="2013" >2013</option> <option value="2012" >2012</option> <option value="2011" >2011</option> <option value="2010" >2010</option> <option value="2009" >2009</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--category">Category</label> <select id="archive-filters__control--category" data-name="category" class="archive-filters__control"> <option value="" >Show all</option> <option value="10th-anniversary" >10th Anniversary</option> <option value="15th-anniversary" >15th Anniversary</option> <option value="access" >Access</option> <option value="allergies" >Allergies</option> <option value="alzheimers-disease" >Alzheimer's Disease</option> <option value="behind-the-paper" >Behind the Paper</option> <option value="big-food" >Big Food</option> <option value="book-review" >Book Review</option> <option value="buruli-ulcer" >Buruli Ulcer</option> <option value="call-for-papers" >Call for Papers</option> <option value="cancer" >Cancer</option> <option value="cardiology" >Cardiology</option> <option value="chagas" >Chagas</option> <option value="channels" >Channels</option> <option value="cholera-2" >Cholera</option> <option value="cholera" >Cholera</option> <option value="climate-change" >Climate Change</option> <option value="clinical-trials" >Clinical Trials</option> <option value="co-infection" >co-infection</option> <option value="collections" >Collections</option> <option value="conference-news" >Conference news</option> <option value="covid-19" >Covid-19</option> <option value="dementia" >Dementia</option> <option value="dengue" >Dengue</option> <option value="diabetes" >Diabetes</option> <option value="digital-health" >Digital Health</option> <option value="drug-development" >drug development</option> <option value="ebola" >Ebola</option> <option value="editorial" >Editorial</option> <option value="epstein-barr-virus" >Epstein-Barr virus</option> <option value="filariasis" >Filariasis</option> <option value="general" >General</option> <option value="geriatric-medicine" >Geriatric Medicine</option> <option value="geriatrics" >Geriatrics</option> <option value="gerontology" >Gerontology</option> <option value="ghostwriting" >Ghostwriting</option> <option value="global-health" >Global Health</option> <option value="health-related-data" >Health-related data</option> <option value="hepatitis" >Hepatitis</option> <option value="hiv" >HIV</option> <option value="hookworm" >Hookworm</option> <option value="huntingtons-disease" >Huntington’s disease</option> <option value="immunology" >Immunology</option> <option value="jev" >JEV</option> <option value="johns-hopkins-bloomberg-school-of-public-health" >Johns Hopkins Bloomberg School of Public Health.</option> <option value="leishmaniasis" >Leishmaniasis</option> <option value="machine-learning" >Machine Learning</option> <option value="malaria-2" >malaria</option> <option value="malaria" >Malaria</option> <option value="maternal-newborn-and-child-health" >Maternal Newborn and Child Health</option> <option value="meet-your-editor" >Meet Your Editor</option> <option value="mental-health" >Mental Health</option> <option value="microbiology" >Microbiology</option> <option value="migrant-health" >Migrant Health</option> <option value="msf" >MSF</option> <option value="mycetoma" >Mycetoma</option> <option value="ncds" >NCDs</option> <option value="neglected-diseases" >Neglected Diseases</option> <option value="noma" >Noma</option> <option value="nutrition" >Nutrition</option> <option value="obesity" >Obesity</option> <option value="obituary" >Obituary</option> <option value="one-health" >One Health</option> <option value="open-access" >Open Access</option> <option value="pandemic" >Pandemic</option> <option value="pathogens" >Pathogens</option> <option value="patient-care" >Patient Care</option> <option value="pediatrics" >Pediatrics</option> <option value="peer-review" >Peer review</option> <option value="plos-digital-health" >PLOS Digital Health</option> <option value="plos-mental-health" >PLOS Mental Health</option> <option value="podoconiosis" >Podoconiosis</option> <option value="policy" >Policy</option> <option value="polymicrobial-infection" >polymicrobial infection</option> <option value="public" >Public</option> <option value="rabies" >Rabies</option> <option value="refugee-health" >Refugee Health</option> <option value="reproducibility" >Reproducibility</option> <option value="research-ethics" >Research Ethics</option> <option value="research-highlight" >Research Highlight</option> <option value="research-matters" >Research Matters</option> <option value="road-traffic-crashes" >Road Traffic Crashes</option> <option value="schistosomiasis" >Schistosomiasis</option> <option value="soil-science" >Soil Science</option> <option value="special-issues" >Special Issues</option> <option value="strongyloides" >Strongyloides</option> <option value="thought-leadership" >Thought Leadership</option> <option value="trachoma" >Trachoma</option> <option value="trauma" >Trauma</option> <option value="trypanosomiasis" >Trypanosomiasis</option> <option value="tuberculosis" >Tuberculosis</option> <option value="un-sustainable-development-goals" >UN Sustainable Development Goals</option> <option value="uncategorized" >Uncategorized</option> <option value="vaccines" >Vaccines</option> <option value="vectors" >Vectors</option> <option value="virus" >Virus</option> <option value="wash" >WASH</option> <option value="who" >WHO</option> <option value="zika" >Zika</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--post_tag">Tag</label> <select id="archive-filters__control--post_tag" data-name="post_tag" class="archive-filters__control"> <option value="" >Show all</option> <option value="15th-anniversary" >15th anniversary</option> <option value="2030-targets" >2030 targets</option> <option value="41st-union-meeting" >41st Union meeting</option> <option value="4abc" >4ABC</option> <option value="95-95-95" >95-95-95</option> <option value="abortion" >abortion</option> <option value="abstract" >abstract</option> <option value="academia" >academia</option> <option value="access" >access</option> <option value="access-to-healthcare" >Access to healthcare</option> <option value="access-to-medical-care" >access to medical care</option> <option value="access-to-medicines" >Access to medicines</option> <option value="accidents" >accidents</option> <option value="accountable-care-organizations" >Accountable Care Organizations</option> <option value="aco" >ACO</option> <option value="activism" >activism</option> <option value="activity" >activity</option> <option value="acupuncture" >acupuncture</option> <option value="ad-hd" >AD/HD</option> <option value="adiposity" >adiposity</option> <option value="adolescent-girls-and-young-women" >adolescent girls and young women</option> <option value="adolescents" >adolescents</option> <option value="adult-male-circumcision" >adult male circumcision</option> <option value="adult-obesity" >adult obesity</option> <option value="advanced-search" >advanced search</option> <option value="advocacy" >advocacy</option> <option value="affordable-care-act" >Affordable care act</option> <option value="africa" >Africa</option> <option value="africa-cdc" >Africa CDC</option> <option value="aging-populations" >aging populations</option> <option value="aid" >Aid</option> <option value="aid-displacement" >aid displacement</option> <option value="aids" >AIDS</option> <option value="aids-male-circumcision-and-hiv" >AIDS male circumcision and HIV</option> <option value="aids-vaccine" >AIDS vaccine</option> <option value="air-pollution" >air pollution</option> <option value="alcohol" >alcohol</option> <option value="alima" >ALIMA</option> <option value="alltrials" >AllTrials</option> <option value="ambulatory-care" >ambulatory care</option> <option value="amr" >AMR</option> <option value="anemia" >anemia</option> <option value="animal-experiments" >animal experiments</option> <option value="animal-models" >animal models</option> <option value="anniversary" >anniversary</option> <option value="antenatal-care" >antenatal care</option> <option value="anthony-kennedy" >Anthony Kennedy</option> <option value="anthropology" >anthropology</option> <option value="antibiotic-resistance" >antibiotic resistance</option> <option value="antibiotics" >antibiotics</option> <option value="antidepressants" >antidepressants</option> <option value="antimalarials" >antimalarials</option> <option value="antimicrobial" >antimicrobial</option> <option value="antimicrobial-drugs" >antimicrobial drugs</option> <option value="antimicrobial-resistance" >Antimicrobial Resistance</option> <option value="antimicrobial-stewardship" >antimicrobial stewardship</option> <option value="antipsychotics" >antipsychotics</option> <option value="antiretroviral-treatment" >antiretroviral treatment</option> <option value="antivaccination-movements" >antivaccination movements</option> <option value="anxiety" >anxiety</option> <option value="apha" >APHA</option> <option value="armed-conflict" >armed conflict</option> <option value="arrive" >ARRIVE</option> <option value="art" >ART</option> <option value="artemisinin" >artemisinin</option> <option value="article-level-metrics" >article level metrics</option> <option value="ascd" >ASCD</option> <option value="ashg" >ASHG</option> <option value="aspirin" >Aspirin</option> <option value="astmh" >ASTMH</option> <option value="atrial-fibrillation" >atrial fibrillation</option> <option value="austerity" >austerity</option> <option value="author-interview" >author interview</option> <option value="authors" >authors</option> <option value="authorship" >authorship</option> <option value="avian-influenza-a" >avian influenza A</option> <option value="bacteria" >bacteria</option> <option value="bacterial-vaginosis" >bacterial vaginosis</option> <option value="bangladesh" >Bangladesh</option> <option value="barriers" >barriers</option> <option value="bcode" >BCoDE</option> <option value="befen" >BEFEN</option> <option value="behind-the-paper" >behind the paper</option> <option value="bias" >bias</option> <option value="big-data" >big data</option> <option value="big-food" >Big Food</option> <option value="big-pharma" >big pharma</option> <option value="biodiversity" >biodiversity</option> <option value="bioinformatics" >bioinformatics</option> <option value="biomarkers" >biomarkers</option> <option value="biomedical-professionals" >biomedical professionals</option> <option value="biomedical-research" >biomedical research</option> <option value="biomedicine" >biomedicine</option> <option value="biotech" >biotech</option> <option value="bipolar-disorder" >bipolar disorder</option> <option value="birth-asphyxia" >birth asphyxia</option> <option value="blood-clot" >blood clot</option> <option value="blood-stream-infections" >blood stream infections</option> <option value="blood-transfusion" >blood transfusion</option> <option value="blue-marble-health" >Blue Marble Health</option> <option value="bmi" >BMI</option> <option value="book-review" >book review</option> <option value="brain" >brain</option> <option value="brain-drain" >brain drain</option> <option value="brasil" >Brasil</option> <option value="brazil" >Brazil</option> <option value="break-the-cycle" >break the cycle</option> <option value="breast-cancer" >breast cancer</option> <option value="breastfeeding" >breastfeeding</option> <option value="bridging-communities" >bridging communities</option> <option value="budget" >budget</option> <option value="burma" >Burma</option> <option value="caesarean-section" >caesarean section</option> <option value="call-for-action" >call for action</option> <option value="call-for-papers" >call for papers</option> <option value="cambodia" >Cambodia</option> <option value="canada" >Canada</option> <option value="cancer" >Cancer</option> <option value="cancer-detection" >Cancer detection</option> <option value="cancer-screening" >cancer screening</option> <option value="capacity" >capacity</option> <option value="capreomycin" >Capreomycin</option> <option value="cardiac-arrest" >cardiac arrest</option> <option value="cardiology" >Cardiology</option> <option value="cardiovascular" >Cardiovascular</option> <option value="cardiovascular-health" >cardiovascular health</option> <option value="caregivers" >caregivers</option> <option value="cd4" >CD4</option> <option value="celldance" >Celldance</option> <option value="cenex" >CENEX</option> <option value="centers-for-medicare-and-medicaid-services" >Centers for Medicare and Medicaid Services</option> <option value="cervical-cancer" >cervical cancer</option> <option value="chagas-disease" >chagas disease</option> <option value="checklist" >checklist</option> <option value="chemotherapy" >chemotherapy</option> <option value="child-abuse" >child abuse</option> <option value="child-development" >child development</option> <option value="child-health" >child health</option> <option value="child-maltreatment" >child maltreatment</option> <option value="child-mortality" >child mortality</option> <option value="child-neglect" >child neglect</option> <option value="childbirth" >childbirth</option> <option value="childhood-obesity" >childhood obesity</option> <option value="children" >children</option> <option value="china" >china</option> <option value="cholera" >cholera</option> <option value="cholera-vaccine" >Cholera vaccine</option> <option value="chronic-disease" >chronic disease</option> <option value="chronic-diseases" >chronic diseases</option> <option value="chronic-kidney-disease" >chronic kidney disease</option> <option value="cia" >CIA</option> <option value="citations" >citations</option> <option value="civil-rights-and-disease-prevention" >civil rights and disease prevention</option> <option value="civil-society" >civil society</option> <option value="civilian-deaths" >civilian deaths</option> <option value="civilians" >civilians</option> <option value="clean-delivery-kits" >Clean Delivery Kits</option> <option value="climate-change" >climate change</option> <option value="climate-crisis" >climate crisis</option> <option value="climate-justice" >climate justice</option> <option value="clinic" >clinic</option> <option value="clinical-practice" >clinical practice</option> <option value="clinical-research" >clinical research</option> <option value="clinical-studies" >clinical studies</option> <option value="clinical-trial-registration" >clinical trial registration</option> <option value="clinical-trials" >clinical trials</option> <option value="clinicalresearch" >clinicalresearch</option> <option value="clinicians" >clinicians</option> <option value="clostridium-difficile" >Clostridium difficile</option> <option value="cluster-randomized-trials" >cluster randomized trials</option> <option value="co-creation" >co-creation</option> <option value="co-design" >co-design</option> <option value="co-infection" >co-infection</option> <option value="co-proxamol" >co-proxamol</option> <option value="cochlear-implant" >cochlear implant</option> <option value="cochrane-collaboration" >Cochrane Collaboration</option> <option value="cochrane-reviews" >Cochrane Reviews</option> <option value="cohorts" >cohorts</option> <option value="cold-snap" >cold snap</option> <option value="collection" >collection</option> <option value="colonialism" >colonialism</option> <option value="colorectal-cancer" >colorectal cancer</option> <option value="commenting" >commenting</option> <option value="comments" >Comments</option> <option value="commercial-determinants-of-health" >commercial determinants of health</option> <option value="communities" >communities</option> <option value="community" >community</option> <option value="community-engagement" >community engagement</option> <option value="community-health" >community health</option> <option value="community-based-public-health" >community-based public health</option> <option value="comparative-effectiveness" >comparative effectiveness</option> <option value="comparative-effectiveness-research" >Comparative Effectiveness Research</option> <option value="competing-interests" >competing interests</option> <option value="competition" >competition</option> <option value="compulsory-licensing" >compulsory licensing</option> <option value="computational-biology" >computational biology</option> <option value="conference" >conference</option> <option value="conference-news" >conference news</option> <option value="conferences" >conferences</option> <option value="confidentiality" >confidentiality</option> <option value="conflict" >conflict</option> <option value="conflict-and-health" >conflict and health</option> <option value="conflicts-of-interest" >conflicts of interest</option> <option value="congress" >Congress</option> <option value="consort-2010" >CONSORT 2010</option> <option value="container-clinic" >container clinic</option> <option value="contraceptives" >contraceptives</option> <option value="cookstoves" >cookstoves</option> <option value="cop" >COP</option> <option value="cop-15" >COP 15</option> <option value="cop-28" >COP 28</option> <option value="cop-29" >COP 29</option> <option value="cop26" >COP26</option> <option value="copd" >COPD</option> <option value="coronary-heart-disease" >coronary heart disease</option> <option value="coronavirus" >Coronavirus</option> <option value="coronaviruses" >Coronaviruses</option> <option value="cost-of-healthcare" >cost of healthcare</option> <option value="cost-effective" >Cost-Effective</option> <option value="cost-effective-healthcare" >cost-effective healthcare</option> <option value="cost-effectiveness" >Cost-effectiveness</option> <option value="counselling" >counselling</option> <option value="covax" >COVAX</option> <option value="covid" >covid</option> <option value="covid-19" >Covid-19</option> <option value="coxs-bazaar" >Cox's Bazaar</option> <option value="crashes" >crashes</option> <option value="creative-commons" >Creative Commons</option> <option value="creative-re-use" >creative re-use</option> <option value="crisis-mapping" >crisis mapping</option> <option value="crispr" >CRISPR</option> <option value="critical-analysis-of-power" >critical analysis of power</option> <option value="critical-care" >critical care</option> <option value="critical-summary" >critical summary</option> <option value="croi" >CROI</option> <option value="crowdfunding" >crowdfunding</option> <option value="cryptoccocal-meningitis" >cryptoccocal meningitis</option> <option value="cuba" >Cuba</option> <option value="cugh" >CUGH</option> <option value="culturally-safe-care" >culturally safe care</option> <option value="curricula" >curricula</option> <option value="daly" >DALY</option> <option value="dalys" >dalys</option> <option value="data" >Data</option> <option value="data-accessibility" >data accessibility</option> <option value="data-sharing" >Data Sharing</option> <option value="datasets" >datasets</option> <option value="david-stuckler" >david stuckler</option> <option value="deaf" >deaf</option> <option value="death-penalty" >death penalty</option> <option value="death-registration" >death registration</option> <option value="deauville" >Deauville</option> <option value="debt" >debt</option> <option value="decarbonization" >decarbonization</option> <option value="decolonize-global-health" >decolonize global health</option> <option value="decolonizing-global-health" >decolonizing global health</option> <option value="deep-learning" >deep learning</option> <option value="deep-vein-thrombosis" >deep vein thrombosis</option> <option value="dei" >DEI</option> <option value="delphi-technique" >Delphi technique</option> <option value="dementia" >dementia</option> <option value="dengue" >dengue</option> <option value="depression" >depression</option> <option value="detection-tool" >detection tool</option> <option value="developing-world" >developing world</option> <option value="dfid" >DFID</option> <option value="diabetes" >diabetes</option> <option value="diagnosis" >diagnosis</option> <option value="diagnostic-tests" >Diagnostic tests</option> <option value="diagnostics" >diagnostics</option> <option value="diarrhea" >diarrhea</option> <option value="diarrhoea" >diarrhoea</option> <option value="dida" >DIDA</option> <option value="diet" >diet</option> <option value="digital-health" >Digital health</option> <option value="digital-humanitarianism" >digital humanitarianism</option> <option value="digital-literacy" >digital literacy</option> <option value="digital-story" >digital story</option> <option value="disability" >Disability</option> <option value="disaster-reduction" >disaster reduction</option> <option value="disasters" >disasters</option> <option value="disclosure" >disclosure</option> <option value="discrimination" >discrimination</option> <option value="disease-and-xenophobia" >disease and xenophobia</option> <option value="disease-eradication" >disease eradication</option> <option value="disease-mongering" >disease mongering</option> <option value="displacement" >displacement</option> <option value="disruptive-publishing" >disruptive publishing</option> <option value="diversity" >diversity</option> <option value="diversity-equity-inclusion" >diversity equity inclusion</option> <option value="dna-database" >DNA database</option> <option value="dndi" >DNDi</option> <option value="doctors" >doctors</option> <option value="domestic-violence" >domestic violence</option> <option value="dosing" >dosing</option> <option value="drc" >DRC</option> <option value="drug" >drug</option> <option value="drug-approval" >drug approval</option> <option value="drug-development" >drug development</option> <option value="drug-device-regulation" >drug device regulation</option> <option value="drug-device-regulation-transparency-public-accountability" >drug device regulation transparency public accountability</option> <option value="drug-discovery" >Drug discovery</option> <option value="drug-industry" >drug industry</option> <option value="drug-policy" >drug policy</option> <option value="drug-registration" >drug registration</option> <option value="drug-resistance" >drug resistance</option> <option value="drug-users" >Drug Users</option> <option value="drug-resistant-tuberculosis" >drug-resistant tuberculosis</option> <option value="drugs" >drugs</option> <option value="dsm-v" >DSM V</option> <option value="e-prescription" >e-prescription</option> <option value="early-career-researchers" >early career researchers</option> <option value="earthquake" >earthquake</option> <option value="eating-disorders" >eating disorders</option> <option value="ebola" >Ebola</option> <option value="ebola-virus-disease" >Ebola Virus Disease</option> <option value="ecdc" >ECDC</option> <option value="ecg" >ecg</option> <option value="economic-analysis" >economic analysis</option> <option value="economic-burden" >economic burden</option> <option value="economic-development" >economic development</option> <option value="economic-policy" >economic policy</option> <option value="economy" >Economy</option> <option value="ectopic-pregnancy" >ectopic pregnancy</option> <option value="ecuador" >Ecuador</option> <option value="eczema" >eczema</option> <option value="editorial-policy-trials-publishing-registration" >editorial policy trials publishing registration</option> <option value="education" >education</option> <option value="ehealth" >eHealth</option> <option value="elderly-care" >elderly care</option> <option value="electronic-health-records" >electronic health records</option> <option value="electronic-prescription" >electronic prescription</option> <option value="elimination" >Elimination</option> <option value="ema" >EMA</option> <option value="emergencies" >emergencies</option> <option value="emergencies-and-humanitarianism" >emergencies and humanitarianism</option> <option value="emergency-admissions" >emergency admissions</option> <option value="emergency-aid" >Emergency aid</option> <option value="end-of-life-care" >end-of-life care</option> <option value="endometrial-cancer" >endometrial cancer</option> <option value="endoscopy" >endoscopy</option> <option value="england" >England</option> <option value="environment" >environment</option> <option value="environmental-health" >environmental health</option> <option value="epidemic" >epidemic</option> <option value="epidemics" >epidemics</option> <option value="epidemiological-transition" >epidemiological transition</option> <option value="epidemiology" >epidemiology</option> <option value="epigenetics" >epigenetics</option> <option value="epstein-barr-virus" >epstein-barr virus</option> <option value="equity" >equity</option> <option value="equity-extension" >Equity extension</option> <option value="erectile-dysfunction" >erectile dysfunction</option> <option value="esc-guidelines" >ESC guidelines</option> <option value="escherichia-coli" >Escherichia coli</option> <option value="essential-medicines" >essential medicines</option> <option value="estimates" >estimates</option> <option value="ethics" >ethics</option> <option value="ethics-global-health" >ethics global health</option> <option value="ethics-regulation" >ethics regulation</option> <option value="europe" >Europe</option> <option value="european-union" >European Union</option> <option value="evaluation" >evaluation</option> <option value="evidence-to-action-gap" >evidence to action gap</option> <option value="evidence-based-medicine" >evidence-based medicine</option> <option value="evidence-informed-policy" >evidence-informed policy</option> <option value="exercise-program" >exercise program</option> <option value="exhibition" >exhibition</option> <option value="expert-panels" >expert panels</option> <option value="extinction-rebellion" >extinction rebellion</option> <option value="extreme-temperatures" >extreme temperatures</option> <option value="fake-medicines" >fake medicines</option> <option value="family-planning" >family planning</option> <option value="famine" >famine</option> <option value="fat" >fat</option> <option value="fatty-acid" >fatty acid</option> <option value="featured" >featured</option> <option value="fee-waiver" >fee waiver</option> <option value="feedback" >feedback</option> <option value="field-surgery" >field surgery</option> <option value="finance" >finance</option> <option value="financing" >financing</option> <option value="fires" >Fires</option> <option value="first-aid" >First Aid</option> <option value="flood" >Flood</option> <option value="floods" >floods</option> <option value="flu-vaccine" >flu vaccine</option> <option value="food" >food</option> <option value="food-industry" >food industry</option> <option value="food-security" >food security</option> <option value="food-supplement" >food supplement</option> <option value="foodborne-disease" >foodborne disease</option> <option value="forced-migration" >forced migration</option> <option value="foreclosure" >foreclosure</option> <option value="foreign-aid" >foreign aid</option> <option value="fractures" >Fractures</option> <option value="framework" >framework</option> <option value="funding" >funding</option> <option value="fungi" >fungi</option> <option value="g20" >G20</option> <option value="g8" >G8</option> <option value="gastric-cancer" >gastric cancer</option> <option value="gastroenteritis" >gastroenteritis</option> <option value="gavi" >GAVI</option> <option value="gbd2010" >GBD2010</option> <option value="gender" >gender</option> <option value="gender-and-health" >gender and health</option> <option value="gender-bias" >gender bias</option> <option value="gender-disparity" >gender disparity</option> <option value="gender-diverse" >gender diverse</option> <option value="gender-equality" >gender equality</option> <option value="generics" >generics</option> <option value="genetic-factors-of-disease" >genetic factors of disease</option> <option value="genetic-modification" >genetic modification</option> <option value="genetic-risk-prediction" >genetic risk prediction</option> <option value="genetic-tests" >genetic tests</option> <option value="genetically-modified" >genetically modified</option> <option value="genetics" >genetics</option> <option value="genexpert" >GeneXpert</option> <option value="genocide" >genocide</option> <option value="genome-sequencing" >genome sequencing</option> <option value="genomic-medicine" >genomic medicine</option> <option value="genomics" >genomics</option> <option value="genomics-technology" >genomics technology</option> <option value="genotyping" >genotyping</option> <option value="gestational-diabetes" >gestational diabetes</option> <option value="ghana" >ghana</option> <option value="ghostwriting" >Ghostwriting</option> <option value="global-burden-of-disease" >global burden of disease</option> <option value="global-fund" >Global Fund</option> <option value="global-health" >global health</option> <option value="global-health-delivery" >global health delivery</option> <option value="global-health-diplomacy" >Global Health Diplomacy</option> <option value="global-health-education" >global health education</option> <option value="global-health-governance" >global health governance</option> <option value="global-health-initiatives" >global health initiatives</option> <option value="global-health-institutions" >Global Health Institutions</option> <option value="global-health-interventions" >global health interventions</option> <option value="global-health-policy" >global health policy</option> <option value="global-health-security" >global health security</option> <option value="global-health-systems" >Global Health Systems</option> <option value="global-health-tools" >global health tools</option> <option value="global-heatlh" >global heatlh</option> <option value="global-mental-health-practice" >Global Mental Health Practice</option> <option value="global-surgery" >global surgery</option> <option value="globalization" >globalization</option> <option value="governance" >governance</option> <option value="guantanamo-bay" >Guantánamo Bay</option> <option value="guest-blog" >guest blog</option> <option value="guidelines" >guidelines</option> <option value="guidelines-and-guidance" >guidelines and guidance</option> <option value="guinea" >Guinea</option> <option value="guinea-worm" >Guinea worm</option> <option value="gun-control" >Gun Control</option> <option value="gun-deaths" >gun deaths</option> <option value="gun-violence" >Gun Violence</option> <option value="guns" >guns</option> <option value="h-pylori" >H. pylori</option> <option value="h1n1" >H1N1</option> <option value="h5n1" >H5N1</option> <option value="haart" >HAART</option> <option value="haiti" >Haiti</option> <option value="handwashing" >handwashing</option> <option value="harm-reduction" >harm reduction</option> <option value="hbt" >HBT</option> <option value="health" >health</option> <option value="health-actors" >health actors</option> <option value="health-aid" >health aid</option> <option value="health-burden" >health burden</option> <option value="health-care" >health care</option> <option value="health-costs" >health costs</option> <option value="health-data" >health data</option> <option value="health-delivery" >health delivery</option> <option value="health-disparities" >health disparities</option> <option value="health-equity" >health equity</option> <option value="health-information" >health information</option> <option value="health-insurance" >health insurance</option> <option value="health-journalism" >health journalism</option> <option value="health-justice" >health justice</option> <option value="health-policy" >health policy</option> <option value="health-program" >health program</option> <option value="health-promotion" >health promotion</option> <option value="health-reform" >health reform</option> <option value="health-research" >health research</option> <option value="health-research-equity-world-health-report" >health research equity World Health Report</option> <option value="health-research-systems-who-world-health-report" >health research systems WHO World Health Report</option> <option value="health-services" >health services</option> <option value="health-spending" >health spending</option> <option value="health-system" >health system</option> <option value="health-systems" >health systems</option> <option value="health-systems-financing" >Health systems financing</option> <option value="health-systems-guidance" >Health Systems Guidance</option> <option value="health-systems-strengthening" >health systems strengthening</option> <option value="health-technology" >health technology</option> <option value="health-workers" >health workers</option> <option value="health-workforce" >health workforce</option> <option value="healthcare" >Healthcare</option> <option value="healthcare-in-danger" >Healthcare in danger</option> <option value="healthcare-workers" >healthcare workers</option> <option value="healthworkers" >healthworkers</option> <option value="healthy-diet" >healthy diet</option> <option value="hearing" >hearing</option> <option value="heart-disease" >heart disease</option> <option value="heart-failure" >heart failure</option> <option value="helicopter-research" >helicopter research</option> <option value="helminths" >helminths</option> <option value="hemoglobin" >hemoglobin</option> <option value="hepatitis" >hepatitis</option> <option value="hepatitis-c" >hepatitis C</option> <option value="hepatitis-e" >Hepatitis E</option> <option value="herpes-simplex-viruses" >herpes simplex viruses</option> <option value="herpes-zoster" >Herpes Zoster</option> <option value="herpesvirus" >herpesvirus</option> <option value="hib" >Hib</option> <option value="hifa2015" >HIFA2015</option> <option value="high-blood-pressure" >high blood pressure</option> <option value="high-level-plenary-meeting" >high level plenary meeting</option> <option value="high-quality-health-systems" >high quality health systems</option> <option value="hinari" >HINARI</option> <option value="hiv" >HIV</option> <option value="hiv-elimination" >HIV elimination</option> <option value="hiv-prevention" >HIV prevention</option> <option value="hiv-risk" >HIV risk</option> <option value="hiv-stigma" >HIV stigma</option> <option value="hiv-test" >HIV test</option> <option value="hiv-testing" >HIV testing</option> <option value="hiv-transmission" >HIV transmission</option> <option value="hiv-treatment" >HIV treatment</option> <option value="hiv-migration-blood-pressure" >HIV; migration; blood pressure</option> <option value="hiv-aids" >HIV/AIDS</option> <option value="holistic-approach" >holistic approach</option> <option value="home-based-hiv-test" >home-based HIV test</option> <option value="homocysteine" >homocysteine</option> <option value="hookworm" >hookworm</option> <option value="hormone-replacement-therapy" >hormone replacement therapy</option> <option value="hospitals" >hospitals</option> <option value="hotez" >Hotez</option> <option value="hotspots" >hotspots</option> <option value="household-air-pollution" >household air pollution</option> <option value="how-to" >how to</option> <option value="hptn-052" >HPTN-052</option> <option value="hpv" >HPV</option> <option value="hpv-vaccine" >HPV vaccine</option> <option value="hscrp" >hsCRP</option> <option value="hsw" >HSW</option> <option value="human-clinical-trials" >human clinical trials</option> <option value="human-cytomegalovirus" >human cytomegalovirus</option> <option value="human-genome" >human genome</option> <option value="human-physiology" >human physiology</option> <option value="human-resources" >Human resources</option> <option value="human-rights" >human rights</option> <option value="human-subjects" >human subjects</option> <option value="human-trafficking" >human trafficking</option> <option value="humanitarian-crisis" >humanitarian crisis</option> <option value="humanitarian-emergency" >humanitarian emergency</option> <option value="humanitarian-organizations" >Humanitarian Organizations</option> <option value="humanitarianism" >humanitarianism</option> <option value="hunger" >hunger</option> <option value="hygeine" >hygeine</option> <option value="hygiene" >hygiene</option> <option value="hypertension" >hypertension</option> <option value="icrc" >ICRC</option> <option value="idu-and-hiv" >IDU and HIV</option> <option value="ihpi" >IHPI</option> <option value="imf" >IMF</option> <option value="immunity" >immunity</option> <option value="immunization" >immunization</option> <option value="immunology" >immunology</option> <option value="immunotherapy" >Immunotherapy</option> <option value="impact" >impact</option> <option value="implementation" >implementation</option> <option value="in-vitro-fertilisation" >In vitro fertilisation</option> <option value="incentives" >incentives</option> <option value="inclusivity" >inclusivity</option> <option value="incontinence" >incontinence</option> <option value="india" >India</option> <option value="industry" >industry</option> <option value="inequity" >inequity</option> <option value="infants" >infants</option> <option value="infection-cluster" >infection cluster</option> <option value="infection-control" >infection control</option> <option value="infectious-disease" >Infectious disease</option> <option value="infectious-diseases" >infectious diseases</option> <option value="inflammation" >inflammation</option> <option value="influenza" >influenza</option> <option value="informed-consent" >informed consent</option> <option value="injury" >injury</option> <option value="innovation" >innovation</option> <option value="insecticide-treated-nets" >insecticide treated nets</option> <option value="insecticides" >insecticides</option> <option value="insects" >insects</option> <option value="institutional-discount" >institutional discount</option> <option value="institutional-membership" >institutional membership</option> <option value="institutional-review-board" >institutional review board</option> <option value="integrated-treatment" >integrated treatment</option> <option value="integrating-mental-health-series" >Integrating Mental Health Series</option> <option value="interagency-emergency-health-kit" >Interagency Emergency Health Kit</option> <option value="interdisciplinary" >interdisciplinary</option> <option value="intermittent-preventive-treatment" >intermittent preventive treatment</option> <option value="international-aids-conference" >International AIDS Conference</option> <option value="international-health-regulations" >International Health Regulations</option> <option value="international-womens-day" >International Women's Day</option> <option value="intersectionality" >intersectionality</option> <option value="intervention" >intervention</option> <option value="interview" >interview</option> <option value="intimate-partner-violence" >intimate partner violence</option> <option value="intracerebral-hemorrhage" >intracerebral hemorrhage</option> <option value="iphone-app" >iPhone app</option> <option value="ipti" >IPTi</option> <option value="iraq" >Iraq</option> <option value="iraq-war" >iraq war</option> <option value="iron" >Iron</option> <option value="ischemic-heart-disease" >ischemic heart disease</option> <option value="isolation" >isolation</option> <option value="iums2014" >IUMS2014</option> <option value="japan" >Japan</option> <option value="journal-scope" >journal scope</option> <option value="journals" >journals</option> <option value="kaiser-foundation" >Kaiser Foundation</option> <option value="kala-azar" >kala-azar</option> <option value="kemri" >KEMRI</option> <option value="kenya" >Kenya</option> <option value="kidney-disease" >kidney disease</option> <option value="kimberley-page" >Kimberley Page</option> <option value="laboratory-information-system" >laboratory information system</option> <option value="lactated-ringers-solution" >lactated ringer's solution</option> <option value="lamb" >lamb</option> <option value="language-and-medicine" >language and medicine</option> <option value="latin-america" >Latin America</option> <option value="leadership" >leadership</option> <option value="learning-disability" >Learning Disability</option> <option value="leishmania" >Leishmania</option> <option value="leishmaniasis" >Leishmaniasis</option> <option value="life-expectancy" >life expectancy</option> <option value="lifestyle" >lifestyle</option> <option value="listeria" >Listeria</option> <option value="liver" >liver</option> <option value="liver-disease" >liver disease</option> <option value="lives-saved" >lives saved</option> <option value="livestock" >livestock</option> <option value="lmic" >LMIC</option> <option value="lmics" >LMICs</option> <option value="local-health-systems" >local health systems</option> <option value="lockdown" >lockdown</option> <option value="low-cost-low-tech-health-tools" >low cost low tech health tools</option> <option value="low-cost-technologies" >low-cost technologies</option> <option value="lung-cancer" >lung cancer</option> <option value="lymphatic-filariasis" >lymphatic filariasis</option> <option value="m-pneumoniae" >M. pneumoniae</option> <option value="machine-learning" >machine learning</option> <option value="macular-degeneration" >macular degeneration</option> <option value="malaria" >malaria</option> <option value="malaria-atlas-project" >Malaria Atlas Project</option> <option value="malaria-surveillance" >malaria surveillance</option> <option value="malawi" >malawi</option> <option value="male-circumcision-and-hiv" >male circumcision and HIV</option> <option value="malera" >malERA</option> <option value="malnutrition" >malnutrition</option> <option value="management-academia" >management academia</option> <option value="mapping" >Mapping</option> <option value="marburg-virus" >Marburg virus</option> <option value="mark-mclellan" >Mark McLellan</option> <option value="mary-moran" >Mary Moran</option> <option value="masks" >masks</option> <option value="maternal-and-child-health" >maternal and child health</option> <option value="maternal-and-perinatal-health" >maternal and perinatal health</option> <option value="maternal-health" >maternal health</option> <option value="maternal-healthpregnancy-complications-malaria" >maternal health;pregnancy complications; malaria</option> <option value="maternal-mortality" >maternal mortality</option> <option value="maternal-newborn-and-child-health" >maternal newborn and child health</option> <option value="mathematical-modelling" >mathematical modelling</option> <option value="mdg" >MDG</option> <option value="measles" >measles</option> <option value="measuring-coverage-in-maternal" >Measuring Coverage in Maternal</option> <option value="medecins-sans-frontieres" >Médecins Sans Frontières</option> <option value="media" >Media</option> <option value="medicaid" >Medicaid</option> <option value="medical-device-regulation" >medical device regulation</option> <option value="medical-devices" >medical devices</option> <option value="medical-education" >medical education</option> <option value="medical-history" >medical history</option> <option value="medical-journal" >medical journal</option> <option value="medical-journalism" >medical journalism</option> <option value="medical-journals" >medical journals</option> <option value="medical-literature" >medical literature</option> <option value="medical-oxygen" >medical oxygen</option> <option value="medical-research" >medical research</option> <option value="medical-students" >medical students</option> <option value="medicine" >medicine</option> <option value="medicine-distribution" >medicine distribution</option> <option value="medicines-patent-pool" >Medicines Patent Pool</option> <option value="mediterranean-diet" >Mediterranean diet</option> <option value="medsin" >medsin</option> <option value="medsin-conference" >Medsin conference</option> <option value="melanoma" >melanoma</option> <option value="mena" >MENA</option> <option value="meningitis" >meningitis</option> <option value="menstrual-health" >menstrual health</option> <option value="mental-health" >Mental Health</option> <option value="mental-illness" >mental illness</option> <option value="mers" >MERS</option> <option value="meta-analysis" >meta-analysis</option> <option value="metformin" >Metformin</option> <option value="method" >method</option> <option value="mexico" >Mexico</option> <option value="mgd" >mgd</option> <option value="mhealth" >mHealth</option> <option value="microbiology" >microbiology</option> <option value="microbiome" >microbiome</option> <option value="micronutrients" >micronutrients</option> <option value="microscopy" >microscopy</option> <option value="midwifery" >midwifery</option> <option value="midwives" >midwives</option> <option value="migrant-health" >migrant health</option> <option value="migration" >Migration</option> <option value="migration-and-health" >Migration and Health</option> <option value="mild-cognitive-impairment" >Mild Cognitive Impairment</option> <option value="millenium-development-goal" >Millenium Development Goal</option> <option value="millennium-development-goals" >millennium development goals</option> <option value="minimum-residual-disease" >Minimum residual disease</option> <option value="mobile-clinic" >mobile clinic</option> <option value="mobile-health" >mobile health</option> <option value="mobile-technology" >mobile technology</option> <option value="model-organism" >model organism</option> <option value="monkeypox" >monkeypox</option> <option value="mortality" >mortality</option> <option value="mosquito-nets" >mosquito nets</option> <option value="mosquito-born-disease" >mosquito-born disease</option> <option value="mpox" >mpox</option> <option value="mrsa" >MRSA</option> <option value="msf" >MSF</option> <option value="msf-scientific-days" >MSF scientific days</option> <option value="msm" >MSM</option> <option value="muac" >MUAC</option> <option value="multi-bi-financing" >multi-bi financing</option> <option value="multi-drug-resistant-tuberculosis" >multi-drug resistant tuberculosis</option> <option value="mumbai" >mumbai</option> <option value="mycology" >mycology</option> <option value="nairobi" >Nairobi</option> <option value="narcotics" >narcotics</option> <option value="narrative-medicine" >narrative medicine</option> <option value="nathan-ford" >Nathan Ford</option> <option value="national-health-systems" >national health systems</option> <option value="national-heart-month" >national heart month</option> <option value="natural-disasters" >natural disasters</option> <option value="nature" >nature</option> <option value="ncds" >NCDs</option> <option value="neglected-diseases" >Neglected Diseases</option> <option value="neglected-tropical-diseases" >neglected tropical diseases</option> <option value="neoadjuvant-therapy" >neoadjuvant therapy</option> <option value="neonatal" >Neonatal</option> <option value="neonatal-health" >neonatal health</option> <option value="neonatal-mortality" >neonatal mortality</option> <option value="neonatal-sepsis" >neonatal sepsis</option> <option value="neurological-disorders" >neurological disorders</option> <option value="nevirapine" >Nevirapine</option> <option value="newborn" >Newborn</option> <option value="newborn-health" >newborn health</option> <option value="news-coverage" >news coverage</option> <option value="ngo" >NGO</option> <option value="nhs" >NHS</option> <option value="nice" >NICE</option> <option value="niger" >Niger</option> <option value="nigeria" >Nigeria</option> <option value="no-child-out-of-reach" >No child out of reach</option> <option value="non-communicable-disease" >non-communicable disease</option> <option value="noncommunicable-diseases" >noncommunicable diseases</option> <option value="north-korea" >North Korea</option> <option value="npr-worm-week" >NPR Worm Week</option> <option value="nsaids" >NSAIDs</option> <option value="ntd" >NTD</option> <option value="ntds" >ntds</option> <option value="nuclear-receptor" >nuclear receptor</option> <option value="nuffield" >Nuffield</option> <option value="nursing" >nursing</option> <option value="nutrition" >nutrition</option> <option value="obesity" >obesity</option> <option value="obituary" >Obituary</option> <option value="off-label-pharmaceutical-use" >off-label pharmaceutical use</option> <option value="one-health" >One Health</option> <option value="onehealth" >OneHealth</option> <option value="open-access" >open access</option> <option value="open-data" >open data</option> <option value="oral-health" >oral health</option> <option value="outbreak" >outbreak</option> <option value="outbreak-response" >outbreak response</option> <option value="outcomes-standardisation-clinical-trials" >outcomes standardisation clinical trials</option> <option value="ovarian-cancer" >ovarian cancer</option> <option value="overdiagnosis" >overdiagnosis</option> <option value="overweight-and-obesity" >overweight and obesity</option> <option value="oxytocin" >oxytocin</option> <option value="p-vivax-malaria" >p vivax malaria</option> <option value="pain-relief" >pain relief</option> <option value="pakistan" >Pakistan</option> <option value="palliative-care" >palliative care</option> <option value="pancreatic-cancer" >pancreatic cancer</option> <option value="pandemic" >pandemic</option> <option value="pandemic-preparedness" >pandemic preparedness</option> <option value="pandemic-response" >pandemic response</option> <option value="pandemic-treaty" >pandemic treaty</option> <option value="parasitology" >parasitology</option> <option value="parkinson-disease" >Parkinson Disease</option> <option value="parkinsons-disease" >Parkinson's disease</option> <option value="participation" >participation</option> <option value="patent" >Patent</option> <option value="patents" >patents</option> <option value="pathogen" >Pathogen</option> <option value="pathogen-genomics" >pathogen genomics</option> <option value="pathogenesis" >pathogenesis</option> <option value="pathogens" >pathogens</option> <option value="patient-care" >patient care</option> <option value="patient-engagement" >Patient engagement</option> <option value="patient-information" >patient information</option> <option value="patient-interaction" >patient interaction</option> <option value="patient-outcomes" >patient outcomes</option> <option value="patient-perspectives" >Patient perspectives</option> <option value="patient-safety" >patient safety</option> <option value="patient-support-groups" >patient support groups</option> <option value="patient-voices" >Patient voices</option> <option value="patients" >patients</option> <option value="pcv7" >PCV7</option> <option value="pearls" >Pearls</option> <option value="pediatric" >pediatric</option> <option value="pediatric-hiv" >pediatric HIV</option> <option value="pediatrics" >pediatrics</option> <option value="peer-review" >peer review</option> <option value="peer-review-quality-publishing-journals" >peer review quality publishing journals</option> <option value="peer-violence" >peer violence</option> <option value="pepfar" >PEPFAR</option> <option value="perinatal-depression" >perinatal depression</option> <option value="person-centered" >person-centered</option> <option value="personalised-medicine" >Personalised medicine</option> <option value="personalized-genomics" >personalized genomics</option> <option value="pertussis" >pertussis</option> <option value="pesticides" >pesticides</option> <option value="peter-hotez" >Peter Hotez</option> <option value="pharmaceutical-industry" >pharmaceutical industry</option> <option value="pharmaceutical-promotion" >pharmaceutical promotion</option> <option value="pharmacists" >pharmacists</option> <option value="pharmacovigilance" >pharmacovigilance</option> <option value="photography" >photography</option> <option value="physical-activity" >physical activity</option> <option value="physicians" >physicians</option> <option value="planet" >planet</option> <option value="planetary-health" >planetary health</option> <option value="plant-pathogens" >plant pathogens</option> <option value="plasmodium-falciparum" >Plasmodium Falciparum</option> <option value="plasmodium-vivax" >Plasmodium vivax</option> <option value="plos" >PLoS</option> <option value="plos-collection" >PLOS Collection</option> <option value="plos-currents" >PLOS Currents</option> <option value="plos-digital-health" >PLOS Digital Health</option> <option value="plos-global-public-health" >PLOS Global Public Health</option> <option value="plos-medicine" >PLoS Medicine</option> <option value="plos-medicine-week-by-week" >PLoS Medicine Week by Week</option> <option value="plos-mental-health" >PLOS Mental Health</option> <option value="plos-ntds" >PLOS NTDs</option> <option value="plos-one" >PLoS ONE</option> <option value="plos-pathogens" >PLoS Pathogens</option> <option value="plos-science-wednesday" >PLOS Science Wednesday</option> <option value="pmac" >PMAC</option> <option value="pmtct" >PMTCT</option> <option value="pneomonia" >pneomonia</option> <option value="pneumococcal-disease" >pneumococcal disease</option> <option value="pneumococcal-infection-vaccine" >pneumococcal infection vaccine</option> <option value="pneumonia" >pneumonia</option> <option value="pocus" >POCUS</option> <option value="point-of-care" >point-of-care</option> <option value="police-activity" >Police Activity</option> <option value="police-brutality" >police brutality</option> <option value="policy" >Policy</option> <option value="policy-cures" >Policy Cures</option> <option value="policy-development" >policy development</option> <option value="policy-making-processes" >policy-making processes</option> <option value="polio" >polio</option> <option value="polio-eradication" >polio eradication</option> <option value="politics" >politics</option> <option value="pollution" >pollution</option> <option value="polymicrobial-infection" >polymicrobial infection</option> <option value="population-density" >population density</option> <option value="post-traumatic-stress-disorder" >Post traumatic stress disorder</option> <option value="post-2015-development-agenda" >post-2015 development agenda</option> <option value="postpardum-depression" >postpardum depression</option> <option value="poverty" >poverty</option> <option value="pre-exposure-prophylaxis" >pre-exposure prophylaxis</option> <option value="pre-exposure-prophylaxis-trial" >pre-exposure prophylaxis trial</option> <option value="precision-medicine" >precision medicine</option> <option value="preeclampsia" >preeclampsia</option> <option value="pregnancy" >pregnancy</option> <option value="pregnancy-complications" >pregnancy complications</option> <option value="premature-birth" >premature birth</option> <option value="prenatal-health" >prenatal health</option> <option value="prep" >PREP</option> <option value="prescription-drugs" >prescription drugs</option> <option value="press" >press</option> <option value="preterm-birth" >preterm birth</option> <option value="preventable-deaths" >preventable deaths</option> <option value="preventable-diseases" >preventable diseases</option> <option value="preventative-cardiology" >Preventative cardiology</option> <option value="prevention" >prevention</option> <option value="primaquine" >primaquine</option> <option value="primary-care" >primary care</option> <option value="primary-health-care" >primary health care</option> <option value="prions" >prions</option> <option value="prisma" >PRISMA</option> <option value="prisma-e" >PRISMA-E</option> <option value="prison" >prison</option> <option value="prison-health" >prison health</option> <option value="prisoners" >prisoners</option> <option value="prisons" >prisons</option> <option value="privacy" >privacy</option> <option value="prognosis" >prognosis</option> <option value="prognostic-research" >prognostic research</option> <option value="prostate-cancer" >Prostate Cancer</option> <option value="protocols" >protocols</option> <option value="psychiatric-drugs" >psychiatric drugs</option> <option value="psychiatry" >psychiatry</option> <option value="psychosocial-intervention" >psychosocial intervention</option> <option value="psychotic-disorders" >psychotic disorders</option> <option value="psychotropics" >psychotropics</option> <option value="psycotherapy" >psycotherapy</option> <option value="ptsd" >PTSD</option> <option value="public-access" >Public Access</option> <option value="public-engagement" >public engagement</option> <option value="public-health" >public health</option> <option value="public-health-emergency" >public health emergency</option> <option value="public-health-policy" >public health policy</option> <option value="public-policy" >public policy</option> <option value="publication-bias" >publication bias</option> <option value="publication-ethics" >Publication Ethics</option> <option value="publication-fee" >publication fee</option> <option value="publishing" >publishing</option> <option value="pubmed" >PubMed</option> <option value="pulmonary-embolism" >pulmonary embolism</option> <option value="quality-control" >quality control</option> <option value="quality-improvement" >quality improvement</option> <option value="quality-of-life" >quality of life</option> <option value="quality-research" >quality research</option> <option value="quarantine" >quarantine</option> <option value="rd" >R&D</option> <option value="racial-disparities" >racial disparities</option> <option value="racial-inequity" >racial inequity</option> <option value="racism" >racism</option> <option value="racism-and-health" >racism and health</option> <option value="randomized-clinical-trials" >randomized clinical trials</option> <option value="randomized-controlled-trials" >randomized controlled trials</option> <option value="rape" >Rape</option> <option value="rapid-impact-interventions" >rapid impact interventions</option> <option value="raynauds-disease" >Raynauds disease</option> <option value="reflexivity" >reflexivity</option> <option value="refugee-health" >Refugee health</option> <option value="refugees" >Refugees</option> <option value="registration-systematic-reviews-reporting-policy" >registration systematic reviews reporting policy</option> <option value="regulation" >regulation</option> <option value="regulations" >regulations</option> <option value="regulatory-approval" >regulatory approval</option> <option value="remark-guidelines" >REMARK guidelines</option> <option value="remotemonitoring" >Remotemonitoring</option> <option value="renewable-energy" >Renewable energy</option> <option value="reparations" >reparations</option> <option value="report" >report</option> <option value="reporting" >reporting</option> <option value="reporting-guidelines" >Reporting guidelines</option> <option value="reproductive-health" >reproductive health</option> <option value="reproductive-health-and-rights" >reproductive health and rights</option> <option value="reproductive-rights" >reproductive rights</option> <option value="research" >research</option> <option value="research-development" >Research & Development</option> <option value="research-and-development" >research and development</option> <option value="research-consortium" >research consortium</option> <option value="research-ethics" >research ethics</option> <option value="research-funding" >Research funding</option> <option value="research-governance" >research governance</option> <option value="research-integrity" >Research Integrity</option> <option value="research-matters" >research matters</option> <option value="research-priority" >research priority</option> <option value="research-quality" >research quality</option> <option value="respiratory-health" >respiratory health</option> <option value="respiratory-syncytial-virus" >respiratory syncytial virus</option> <option value="retractions" >retractions</option> <option value="reviewers" >reviewers</option> <option value="reviews" >reviews</option> <option value="rheumatoid-arthritis" >rheumatoid arthritis</option> <option value="riat-initiative" >RIAT initiative</option> <option value="rinderpest" >Rinderpest</option> <option value="risk-behavior" >risk behavior</option> <option value="risk-factors" >risk factors</option> <option value="risk-perception" >risk perception</option> <option value="river-blindness" >river blindness</option> <option value="rna" >RNA</option> <option value="rna-profile" >RNA profile</option> <option value="rnai" >RNAi</option> <option value="road" >road</option> <option value="road-safety" >road safety</option> <option value="rotavirus" >rotavirus</option> <option value="rural" >rural</option> <option value="rusf" >RUSF</option> <option value="russia" >Russia</option> <option value="rwanda" >Rwanda</option> <option value="safety" >safety</option> <option value="sanitation" >sanitation</option> <option value="sanjay-basu" >Sanjay Basu</option> <option value="sars" >SARS</option> <option value="sars-cov-2" >SARS-Cov-2</option> <option value="sars-cov2" >SARS-Cov2</option> <option value="save-the-children" >Save the children</option> <option value="scale-up" >scale-up</option> <option value="scaling-up" >scaling up</option> <option value="schistosomiasis" >schistosomiasis</option> <option value="schmallenberg" >Schmallenberg</option> <option value="school-lunch" >school lunch</option> <option value="school-meals" >school meals</option> <option value="scicomm" >scicomm</option> <option value="science" >science</option> <option value="science-cafe" >science cafe</option> <option value="science-diplomacy" >Science diplomacy</option> <option value="science-education" >science education</option> <option value="scientific-misconduct" >scientific misconduct</option> <option value="scientific-publishing" >scientific publishing</option> <option value="scleroderma" >scleroderma</option> <option value="screening" >screening</option> <option value="sdgs" >SDGs</option> <option value="seasonal-influenza" >seasonal influenza</option> <option value="second-global-forum-on-health-and-human-resources" >Second Global Forum on health and human resources</option> <option value="secondhand-smoke" >secondhand smoke</option> <option value="section-editor" >section editor</option> <option value="self-injury" >self-injury</option> <option value="self-testing" >self-testing</option> <option value="seniors" >Seniors</option> <option value="sepsis" >sepsis</option> <option value="serodiscordant-couples" >serodiscordant couples</option> <option value="serologic-testing" >serologic testing</option> <option value="service-experience" >service experience</option> <option value="severe-malaria" >severe malaria</option> <option value="sex" >sex</option> <option value="sex-workers" >sex workers</option> <option value="sexual-and-gender-minority" >sexual and gender minority</option> <option value="sexual-and-reproductive-health" >sexual and reproductive health</option> <option value="sexual-assault" >sexual assault</option> <option value="sexual-health" >sexual health</option> <option value="sexual-inequality" >Sexual Inequality</option> <option value="shift-work" >shift work</option> <option value="shingles" >Shingles</option> <option value="sickle-cell-anemia" >sickle cell anemia</option> <option value="sigmoidoscopy" >sigmoidoscopy</option> <option value="sign-language" >sign language</option> <option value="silica-dust" >silica dust</option> <option value="simsmoke" >SimSmoke</option> <option value="sleeping-sickness" >Sleeping sickness</option> <option value="smallpox" >smallpox</option> <option value="smog" >smog</option> <option value="smoke-free-legislation" >smoke-free legislation</option> <option value="smokeless-tobacco" >smokeless tobacco</option> <option value="smoking" >smoking</option> <option value="smoking-cessation" >smoking cessation</option> <option value="snus" >snus</option> <option value="social-determinants-of-health" >social determinants of health</option> <option value="social-distancing" >social distancing</option> <option value="social-entrepreneurship" >social entrepreneurship</option> <option value="social-inequality" >social inequality</option> <option value="social-justice" >social justice</option> <option value="social-media" >Social Media</option> <option value="social-medicine" >social medicine</option> <option value="social-networks" >social networks</option> <option value="social-policy" >Social Policy</option> <option value="social-protection" >social protection</option> <option value="socioeconomic-status" >socioeconomic status</option> <option value="soda-tax" >soda tax</option> <option value="south-africa" >South Africa</option> <option value="south-east-asia" >South East Asia</option> <option value="southern-africa" >Southern Africa</option> <option value="speaking-of-medicine" >speaking of medicine</option> <option value="special-educational-needs" >special educational needs</option> <option value="special-issues" >special issues</option> <option value="sports" >sports</option> <option value="stakeholder-involvement" >stakeholder involvement</option> <option value="staphylococcus-aureus" >Staphylococcus aureus</option> <option value="statins" >Statins</option> <option value="statistical-analysis" >statistical analysis</option> <option value="stem-cell-research" >stem cell research</option> <option value="stem-cells" >stem cells</option> <option value="steve-radelet" >Steve Radelet</option> <option value="stigma" >stigma</option> <option value="stockholm" >Stockholm</option> <option value="stop-tb" >Stop TB</option> <option value="streptococcus-pneumoniae" >streptococcus pneumoniae</option> <option value="stress" >Stress</option> <option value="strobe" >STROBE</option> <option value="stroke" >Stroke</option> <option value="structural-determinants-of-health" >structural determinants of health</option> <option value="student" >student</option> <option value="stunting" >stunting</option> <option value="sub-saharan-africa" >sub-saharan Africa</option> <option value="substance-use" >substance use</option> <option value="sudan" >Sudan</option> <option value="sugar" >sugar</option> <option value="sugar-tax" >Sugar tax</option> <option value="suicide" >Suicide</option> <option value="surgery" >surgery</option> <option value="surgical-provision" >surgical provision</option> <option value="surveillance" >surveillance</option> <option value="survey" >Survey</option> <option value="survivorship" >survivorship</option> <option value="sustainability" >Sustainability</option> <option value="sustainable-development-goals" >Sustainable Development Goals</option> <option value="sutures" >sutures</option> <option value="swine-flu" >swine flu</option> <option value="symposium" >symposium</option> <option value="syphilis" >syphilis</option> <option value="syria" >Syria</option> <option value="systematic-reviews" >systematic reviews</option> <option value="systematic-reviews-registration-protcols-bias" >Systematic reviews registration protcols bias</option> <option value="t-cell" >T cell</option> <option value="t-brucei" >T. brucei</option> <option value="tamiflu" >Tamiflu</option> <option value="tanzania" >Tanzania</option> <option value="targeted-health-interventions" >targeted health interventions</option> <option value="targets" >Targets</option> <option value="tb" >TB</option> <option value="teleresearch" >teleresearch</option> <option value="thailand" >Thailand</option> <option value="the-future" >the future</option> <option value="the-global-fund" >The Global Fund</option> <option value="therapy" >therapy</option> <option value="thought-leadership" >thought leadership</option> <option value="tobacco" >tobacco</option> <option value="tobacco-control" >tobacco control</option> <option value="tobacco-policy" >tobacco policy</option> <option value="toilet" >toilet</option> <option value="toolkit" >toolkit</option> <option value="torture" >torture</option> <option value="toxin" >toxin</option> <option value="toxoplasmosis" >toxoplasmosis</option> <option value="trachomatous-trichiasis" >trachomatous trichiasis</option> <option value="traffic" >traffic</option> <option value="training" >training</option> <option value="transformation" >transformation</option> <option value="translation" >translation</option> <option value="translational-research" >translational research</option> <option value="trauma" >trauma</option> <option value="trauma-informed-care" >trauma informed care</option> <option value="treatment-adherence" >treatment adherence</option> <option value="treatment-burden" >treatment burden</option> <option value="treatment-gap" >treatment gap</option> <option value="treatment-guidelines" >treatment guidelines</option> <option value="trial-participants" >trial participants</option> <option value="tropmed2020" >TropMed2020</option> <option value="trypanosoma-brucei" >Trypanosoma brucei</option> <option value="tuberc" >tuberc</option> <option value="tuberculosis" >tuberculosis</option> <option value="tuberculosis-management" >tuberculosis management</option> <option value="tuberculous-meningitis" >Tuberculous meningitis</option> <option value="tumor-marker" >tumor marker</option> <option value="tutorial" >tutorial</option> <option value="tweet-chat" >tweet chat</option> <option value="twitter" >twitter</option> <option value="type-2-diabetes" >type 2 diabetes</option> <option value="u-s" >U.S.</option> <option value="uaem" >UAEM</option> <option value="uganda" >Uganda</option> <option value="ukraine" >Ukraine</option> <option value="ultrasound" >ultrasound</option> <option value="un" >UN</option> <option value="unaids" >UNAIDS</option> <option value="under-five" >under-five</option> <option value="undernutrition" >undernutrition</option> <option value="unhealthy-diet" >unhealthy diet</option> <option value="unicef" >UNICEF</option> <option value="united-nations" >United Nations</option> <option value="united-states" >united states</option> <option value="universal-health-care" >universal health care</option> <option value="universities" >universities</option> <option value="universities-allied-for-essential-medicines" >Universities Allied for Essential Medicines</option> <option value="upper-gi-bleed" >upper GI bleed</option> <option value="urban-health" >urban health</option> <option value="us-food-and-drug-administration" >US Food and Drug Administration</option> <option value="us-health-reform" >US health reform</option> <option value="usage-data" >Usage data</option> <option value="vaccination" >vaccination</option> <option value="vaccine" >vaccine</option> <option value="vaccine-equity" >vaccine equity</option> <option value="vaccine-scares" >vaccine scares</option> <option value="vaccines" >Vaccines</option> <option value="vaginal-birth" >vaginal birth</option> <option value="value-based-insurance-design" >Value-Based Insurance Design</option> <option value="vbac" >VBAC</option> <option value="vector-borne-disease" >Vector borne disease</option> <option value="venous-thrombosis" >venous thrombosis</option> <option value="verbal-autopsy" >verbal autopsy</option> <option value="videos" >videos</option> <option value="vietnam" >Vietnam</option> <option value="vinson" >Vinson</option> <option value="violence" >Violence</option> <option value="viral-load" >viral load</option> <option value="virology" >virology</option> <option value="virus" >virus</option> <option value="visa-privledge" >visa privledge</option> <option value="visceral-leishmaniasis" >visceral leishmaniasis</option> <option value="visceral-leishmanis" >Visceral leishmanis</option> <option value="vivax" >vivax</option> <option value="vmmc2014" >VMMC2014</option> <option value="war" >war</option> <option value="warfare" >warfare</option> <option value="wash" >wash</option> <option value="washwatch" >WASHwatch</option> <option value="water" >water</option> <option value="water-and-sanitation" >Water and Sanitation</option> <option value="west-africa" >West Africa</option> <option value="whistleblowers" >whistleblowers</option> <option value="white-coats" >white coats</option> <option value="who" >WHO</option> <option value="who-reforms" >WHO reforms</option> <option value="wiki-book" >wiki-book</option> <option value="women" >women</option> <option value="women-in-science" >women in science</option> <option value="womens-health" >Women's health</option> <option value="womens-rights" >women's rights</option> <option value="world-bank" >world bank</option> <option value="world-bank-president" >world bank president</option> <option value="world-environment-day" >world environment day</option> <option value="world-food-programme" >World Food Programme</option> <option value="world-health-assembly" >World Health Assembly</option> <option value="world-health-day" >World health day</option> <option value="world-health-organization" >World Health Organization</option> <option value="world-health-report" >World Health Report</option> <option value="world-kidney-day" >World Kidney Day</option> <option value="world-malaria-day" >World Malaria Day</option> <option value="world-ntds-day" >World NTDs Day</option> <option value="world-pneumonia-day" >world pneumonia day</option> <option value="world-report-on-disability" >world report on disability</option> <option value="world-tb-day" >World TB day</option> <option value="world-toilet-day" >World toilet day</option> <option value="world-trade-organization" >World Trade Organization</option> <option value="world-water-day" >world water day</option> <option value="world-water-week" >World water week</option> <option value="worm-week" >worm week</option> <option value="xmrv" >XMRV</option> <option value="xpert" >Xpert</option> <option value="young-persons" >Young Persons</option> <option value="youth" >Youth</option> <option value="zambia" >Zambia</option> <option value="zimbabwe" >Zimbabwe</option> <option value="zinc" >zinc</option> <option value="zoonoses" >Zoonoses</option> <option value="zoonotic-diseases" >zoonotic diseases</option> </select> </div> <div class="archive-filters__submit-container"> <input type="submit" value="Go" /> </div> <div class="archive-filters__view-controls"> <span class="archive-filters__view-label">View Style</span> <ul> <li><a class="archive-filters__view-control archive-filters__view-control--grid" data-style="grid">Grid view</a></li> <li><a class="archive-filters__view-control archive-filters__view-control--list archive-filters__view-control--active" data-style="list">List view</a></li> </ul> </div> </div> <div class="archive-filters__rss"> <span class="archive-filters__rss-label">Follow this Blog</span> <br /> <a class="archive-filters__rss-link" href="https://speakingofmedicine.plos.org/feed/"><i class="fas fa-rss"></i> RSS</a> </div> </fieldset> </form> <ul class="post-list post-list--list post-list--non-elementor" id="posts"> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/11/21/plos-mental-health-community-case-studies-the-importance-of-the-asenze-cohort-study-in-supporting-adolescent-mental-health-in-under-resourced-settings/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/06/Community-Case-studies-1024x458.png);" title="PLOS Mental Health Community Case Studies: The Importance of the Asenze Cohort Study in Supporting Adolescent Mental Health in Under-Resourced Settings"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/11/21/plos-mental-health-community-case-studies-the-importance-of-the-asenze-cohort-study-in-supporting-adolescent-mental-health-in-under-resourced-settings/">PLOS Mental Health Community Case Studies: The Importance of the Asenze Cohort Study in Supporting Adolescent Mental Health in Under-Resourced Settings</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 21, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>In our final ‘Community Case Studies’ blog of 2024, PLOS Mental Health speaks to Kathryn Grace Watt (University of Kwazulu-Natal, Durban) and…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/11/21/plos-mental-health-community-case-studies-the-importance-of-the-asenze-cohort-study-in-supporting-adolescent-mental-health-in-under-resourced-settings/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/11/20/diverted-dollars-the-health-impact-of-africas-debt-crisis/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-6.gif);" title="Diverted Dollars: The Health Impact of Africa’s Debt Crisis"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Global Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/11/20/diverted-dollars-the-health-impact-of-africas-debt-crisis/">Diverted Dollars: The Health Impact of Africa’s Debt Crisis</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 20, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/jrobinson/">PLOS Global Public Health</a></span> </div> <div class="post-list__post-excerpt"> <p>By guest contributors Riya Sawhney, Gabriella Y. Hyman, Nikathan Kumar, Nakul P. Raykar, and Kee B. Park Africa has a debt problem…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/11/20/diverted-dollars-the-health-impact-of-africas-debt-crisis/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/11/19/cycles-and-crisis-menstrual-health-for-climate-justice/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-3.gif);" title="Cycles and Crisis: Menstrual Health for Climate Justice"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Global Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/11/19/cycles-and-crisis-menstrual-health-for-climate-justice/">Cycles and Crisis: Menstrual Health for Climate Justice</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 19, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/jrobinson/">PLOS Global Public Health</a></span> </div> <div class="post-list__post-excerpt"> <p>By guest contributors Nadirah Babji, Dr. Jennifer S. Martin, Dr. Bismah Nayyer, Dr. Muskaan Bhan, and Nour Toukan The lack of representation…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/11/19/cycles-and-crisis-menstrual-health-for-climate-justice/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/11/13/amplifying-the-global-south-voice-for-an-inclusive-global-health-research-landscape/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-6.gif);" title="Amplifying the Global South Voice for an Inclusive Global Health Research Landscape"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Global Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/11/13/amplifying-the-global-south-voice-for-an-inclusive-global-health-research-landscape/">Amplifying the Global South Voice for an Inclusive Global Health Research Landscape</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 13, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/jrobinson/">PLOS Global Public Health</a></span> </div> <div class="post-list__post-excerpt"> <p>By guest contributors Karima Chaabna and Sohaila Cheema Global North institutions and experts have long dominated the global research agenda, leading major…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/11/13/amplifying-the-global-south-voice-for-an-inclusive-global-health-research-landscape/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/11/11/exposing-the-politics-of-foreign-aid-diplomacy-and-reproductive-health-a-book-review-of-sophie-harmans-sick-of-it-the-global-fight-for-womens-health/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/11/Sick-of-it-book.jpg);" title="Exposing the Politics of Foreign Aid, Diplomacy, and Reproductive Health: A book review of Sophie Harman’s Sick of It: The Global Fight for Women’s Health"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Book Review</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/11/11/exposing-the-politics-of-foreign-aid-diplomacy-and-reproductive-health-a-book-review-of-sophie-harmans-sick-of-it-the-global-fight-for-womens-health/">Exposing the Politics of Foreign Aid, Diplomacy, and Reproductive Health: A book review of Sophie Harman’s Sick of It: The Global Fight for Women’s Health</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 11, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/jrobinson/">PLOS Global Public Health</a></span> </div> <div class="post-list__post-excerpt"> <p>By guest contributor Sophie Arseneault The repercussions of colonialism are not limited to its legacies’ imprint on the framework of global health…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/11/11/exposing-the-politics-of-foreign-aid-diplomacy-and-reproductive-health-a-book-review-of-sophie-harmans-sick-of-it-the-global-fight-for-womens-health/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/31/a-year-of-plos-mental-health/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/10/investment-5241253_1280-1024x682.jpg);" title="A Year of PLOS Mental Health"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/31/a-year-of-plos-mental-health/">A Year of PLOS Mental Health</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 31, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>PLOS Mental Health’s First Year 2024 is flying by and November 1st marks the one year anniversary since PLOS Mental Health launched…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/31/a-year-of-plos-mental-health/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/28/plos-mental-healths-the-bigger-picture/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/07/eye-5646463_1280-1024x1024.jpg);" title="PLOS Mental Health’s ‘The Bigger Picture’."></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/28/plos-mental-healths-the-bigger-picture/">PLOS Mental Health’s ‘The Bigger Picture’.</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 28, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>PLOS Mental Health recently introduced a quarterly seminar series: ‘The Bigger Picture’. In this series, we are aiming to promote work in…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/28/plos-mental-healths-the-bigger-picture/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/25/project-smile-how-a-community-based-psychosocial-intervention-is-transforming-mental-health-in-the-middle-east/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/10/nick-fewings-WqO0As9Od8U-unsplash-1024x683.jpg);" title="Project Smile: How A Community-Based Psychosocial Intervention Is Transforming Mental Health in the Middle East"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/25/project-smile-how-a-community-based-psychosocial-intervention-is-transforming-mental-health-in-the-middle-east/">Project Smile: How A Community-Based Psychosocial Intervention Is Transforming Mental Health in the Middle East</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 25, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/asnider/">Audrey Snider</a></span> </div> <div class="post-list__post-excerpt"> <p>Photo by Nick Fewings on Unsplash Authors: Madeera Mian, Ahmed Alazbat, Dr. Julie Franck, Dr. Jess Ghannam. Header photo by Nick Fewings on Unsplash. Background The mental health…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/25/project-smile-how-a-community-based-psychosocial-intervention-is-transforming-mental-health-in-the-middle-east/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/21/getting-to-know-plos-mental-health-environmental-impacts/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/07/play-stone-1738158_1280-1024x687.jpg);" title="Getting to know PLOS Mental Health: Environmental Impacts"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/21/getting-to-know-plos-mental-health-environmental-impacts/">Getting to know PLOS Mental Health: Environmental Impacts</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 21, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>Over the last few months of our ‘Getting to know PLOS Mental Health‘ series, we have heard from our Section Editors Gloria…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/21/getting-to-know-plos-mental-health-environmental-impacts/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/16/global-public-health-curricula-are-not-fit-for-purpose/" style="background-image: url(https://plos.org/wp-content/uploads/fallback-featured-images/fallback-7.gif);" title="Global Public Health Curricula are Not Fit for Purpose"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Global Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/16/global-public-health-curricula-are-not-fit-for-purpose/">Global Public Health Curricula are Not Fit for Purpose</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 16, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/jrobinson/">PLOS Global Public Health</a></span> </div> <div class="post-list__post-excerpt"> <p>By guest contributors Luchuo Engelbert Bain, Ojong Samuel Akombeng, and Daniel Krugman Global public health education is in crisis. In a world…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/16/global-public-health-curricula-are-not-fit-for-purpose/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/10/world-mental-health-day-2024-at-plos-mental-health-it-is-time-to-prioritize-mental-health-in-the-workplace/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/10/people-5592232_1280-1024x374.jpg);" title="World Mental Health Day 2024 at PLOS Mental Health: It is time to prioritize mental health in the workplace"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/10/world-mental-health-day-2024-at-plos-mental-health-it-is-time-to-prioritize-mental-health-in-the-workplace/">World Mental Health Day 2024 at PLOS Mental Health: It is time to prioritize mental health in the workplace</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 10, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>This year, the theme for World Mental Health Day encourages us to consider the importance of mental health in professional settings. Being…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/10/world-mental-health-day-2024-at-plos-mental-health-it-is-time-to-prioritize-mental-health-in-the-workplace/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://speakingofmedicine.plos.org/2024/10/10/journeys-in-mental-health-i-dont-want-to-talk-about-my-mental-health-at-work/" style="background-image: url(https://speakingofmedicine.plos.org/wp-content/uploads/sites/14/2024/03/journeys_in_mental_health_blog_header-1-1024x475.png);" title="Journeys in Mental Health: I don’t want to talk about my mental health at work"></a> <div class="post-list__post-text"> <span class="post-list__post-label">Mental Health</span> <span class="post-list__post-title"> <a href="https://speakingofmedicine.plos.org/2024/10/10/journeys-in-mental-health-i-dont-want-to-talk-about-my-mental-health-at-work/">Journeys in Mental Health: I don’t want to talk about my mental health at work</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 10, 2024</span> <span class="post-list__post-author">By <a href="https://speakingofmedicine.plos.org/author/karli/">Karli Montague-Cardoso</a></span> </div> <div class="post-list__post-excerpt"> <p>Today is World Mental Health Day, for which the theme is ‘It is time to prioritize mental health in the workplace’. For…</p> </div> <a class="post-list__post-read-more" href="https://speakingofmedicine.plos.org/2024/10/10/journeys-in-mental-health-i-dont-want-to-talk-about-my-mental-health-at-work/">Read more</a> </div> </li> </ul> </div> <div class="archive__pagination archive__pagination--bottom"> <span class="archive__pagination-count">Showing 1 – 12 of 1367 posts</span> <div class="pagination"> <ul class="pagination__list"> <li class="pagination__item pagination__item--prev pagination__item--inactive pagination__item--not-current"> <a>Prev</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--current"> <a href="/">1</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/2/">2</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/3/">3</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/4/">4</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/5/">5</a> </li> <li class="pagination__item pagination__item--dots pagination__item--inactive pagination__item--not-current"> <span class="pagination__dots">...</span> </li> <li class="pagination__item pagination__item--next pagination__item--active pagination__item--not-current"> <a href="/page/2/">Next</a> </li> </ul> <div class="pagination__mobile"> <div class="pagination__link"> <a href="" class="pagination__mobile-link pagination__mobile-link--inactive">Prev</a> </div> <div class="pagination__select-container"> <select class="pagination__select" data-total-pages="114"> <option value="/" selected>1</option> <option value="/page/2/" >2</option> <option value="/page/3/" >3</option> <option value="/page/4/" >4</option> <option value="/page/5/" >5</option> </select> </div> <div class="pagination__link"> <a href="/page/2/" class="pagination__mobile-link pagination__mobile-link--active">Next</a> </div> </div> </div> </div> </div> </main> </div> </div> <style type="text/css"> footer.app-footer { background-color: #050c2b; color: #ffffff; } footer.app-footer a, footer.app-footer label { color: #ffffff; } footer.app-footer input[type=text], footer.app-footer input[type=email] { background-color: #050c2b; border-color: #ffffff; color: #ffffff; } </style> <footer class="app-footer"> <div class="app-footer__container container"> <div class="app-footer__col app-footer__branding"> <a class="app-footer__brand" href="https://speakingofmedicine.plos.org/"> <img class="app-footer__logo" src="https://speakingofmedicine.plos.org/wp-content/uploads/2019/12/logo-white.svg" alt="Speaking of Medicine and Health logo" /> </a> <ul class="social-media-links app-footer__social-media-links"> <li class="social-media-links__item social-media-links__item--twitter"> <a class="social-media-links__link" href="https://twitter.com/plos"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="twitter-icon-title"> <title id="twitter-icon-title">X (former Twitter)</title> <style type="text/css">.svg-twitter-fill{fill: #ffffff;}</style> <path class="svg-twitter-fill" d="M11.7,8.6L18.2,1h-1.6L11,7.6L6.4,1H1.2l6.9,10l-6.9,8h1.6l6-7l4.8,7h5.2L11.7,8.6L11.7,8.6z M9.5,11.1l-0.7-1L3.3,2.2h2.4l4.5,6.4l0.7,1l5.8,8.3h-2.4L9.5,11.1L9.5,11.1z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--facebook"> <a class="social-media-links__link" href="https://www.facebook.com/PLoS.org"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="facebook-icon-title"> <title id="facebook-icon-title">Facebook</title> <style type="text/css">.svg-facebook-fill{fill: #ffffff;}</style> <path class="svg-facebook-fill" d="M19.5 1.5v16.6c0 0.6-0.5 1.2-1.2 1.2h-4.8v-7.4h2.4l0.4-2.7h-2.8V7.1c0-0.8 0.4-1.2 1.2-1.2h1.8V3.4c0 0-0.8-0.1-1.9-0.1 -2.6 0-3.9 1.4-3.9 3.6v2.4H8.3v2.7h2.4v7.4h-9c-0.6 0-1.2-0.5-1.2-1.2V1.5c0-0.6 0.5-1.2 1.2-1.2h16.6C19 0.3 19.5 0.9 19.5 1.5z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--linkedin"> <a class="social-media-links__link" href="https://www.linkedin.com/company/public-library-of-science"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="linkedin-icon-title"> <title id="linkedin-icon-title">Linkedin</title> <style type="text/css">.svg-linkedin-fill{fill: #ffffff;}</style> <path class="svg-linkedin-fill" d="M2.9 5.1L2.9 5.1c-1.4 0-2.4-1-2.4-2.2 0-1.2 0.9-2.2 2.4-2.2 1.4 0 2.3 0.9 2.4 2.2C5.2 4.1 4.3 5.1 2.9 5.1zM4.9 7.1v12.3h-4V7.1H4.9zM11.2 19.3h-4V9.8c0 0-0.1-2.4-0.1-2.8h3.9l0.1 1.7c0.8-1.2 2-2.1 3.6-2.1 2.8 0 4.8 2 4.8 5.5v7.1h-4v-6.7c0-2-1-2.8-2.2-2.8 -1.2 0-2.2 0.8-2.2 2.4V19.3z"/> </svg> </a> </li> </ul> <span class="app-footer__info-text">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, and is based in California, US</span> </div> <div class="app-footer__col app-footer__nav"> <div class="app-footer__nav-container"> <div class="menu-footer-navigation-container"><ul id="menu-footer-navigation" class="app-header__footer-nav"><li id="menu-item-1680" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1680"><a href="https://plos.org/">Home</a></li> <li id="menu-item-309" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-309"><a href="https://plos.org/resources/">Resources</a></li> <li id="menu-item-308" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-308"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-383" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-383"><a href="https://plos.org/open-science/">Open Science</a></li> <li id="menu-item-412" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-412"><a href="https://plos.org/publish/">Publish with PLOS</a></li> <li id="menu-item-419" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-419"><a href="https://plos.org/about/">About PLOS</a></li> <li id="menu-item-34241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34241"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> <li id="menu-item-8117" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8117"><a href="https://plos.org/dei/">Diversity, Equity and Inclusion</a></li> <li id="menu-item-2817" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2817"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-1682" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1682"><a href="https://plos.org/about/contact/">Contact</a></li> <li id="menu-item-1683" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1683"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-1684" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1684"><a href="https://plos.org/careers/">Careers</a></li> <li id="menu-item-1685" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1685"><a href="https://plos.org/advertise/">Advertise</a></li> <li id="menu-item-35167" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-35167"><a href="https://plos.org/financial-overview/">Financial Overview</a></li> <li id="menu-item-25042" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-25042"><a href="https://plos.org/governance/">Governance</a></li> <li id="menu-item-1687" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-1687"><a rel="privacy-policy" href="https://plos.org/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-15441" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15441"><a href="https://plos.org/cookies-policy/">Cookie Policy</a></li> <li id="menu-item-1688" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1688"><a href="https://plos.org/terms-of-use/">Terms of Use</a></li> <li id="menu-item-7340" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7340"><a href="https://plos.org/payment-terms-and-conditions/">Payment Terms and Conditions</a></li> <li id="menu-item-1689" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1689"><a href="https://plos.org/text-and-data-mining/">Text & Data Mining</a></li> <li id="menu-item-11315" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11315"><a href="https://plos.org/terms-of-service/">Terms of Service</a></li> </ul></div> </div> </div> <div class="app-footer__col app-footer__rich-text"> <p><strong>News & Updates</strong></p> <form class="newsletter-signup" action="https://cl.exct.net/subscribe.aspx" name="subscribeForm" method="post"><input type="hidden" name="thx" value="https://www.plos.org/signup-success/"><input type="hidden" name="err" value="https://www.plos.org/signup-error/"><input type="hidden" name="SubAction" value="sub"><input type="hidden" name="MID" value="7207856"><input type="hidden" name="LID" value="5488"><input type="hidden" name="Source" value="WebCollect"><div class="newsletter-signup__input-container newsletter-signup__input-container--text-container"><label for="email-address">Email address</label><input type="email" id="email-address" name="Email Address"></div><div class="newsletter-signup__input-container newsletter-signup__input-container--checkbox-container"><span class="newsletter-signup__disclaimer">PLOS will use your email address to provide news and updates. You can find out more about how PLOS processes your data by reading our <a href="https://plos.org/privacy-policy/">Privacy Policy</a>. You can unsubscribe at any time by clicking the unsubscribe link in our emails or by contacting us at privacy@plos.org.</span></div><div class="newsletter-signup__input-container newsletter-signup__input-container--submit-container"><small class="newsletter-signup__validation-message">All fields are required, please check your entry and try again.</small><input type="submit" value="Submit"></div></form> </div> </div> </footer> <a class="back-to-top" id="back-to-top" href="#top"><span class="screen-reader-text">Back to top</span></a>  <script> /*! For license information please see body.js.LICENSE.txt */ (()=>{var e={490:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}t.Z=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(682)),i=u(n(628));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.Z=function(e){var t,n,r=e.dispatcher,u=(t=(0,a.useState)(!l.default.hasInteracted()),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),s=u[0],f=u[1];return r&&(0,a.useEffect)((function(){return r.sub("open",(function(){return f(!0)}))}),[]),a.default.createElement("div",{className:"cookie-consent"},a.default.createElement(o.default,{show:s}),a.default.createElement(i.default,{close:function(){f(!1)},show:s}))}},682:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=n(357),l=o(n(188));function o(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.show;return r.default.createElement(a.CSSTransition,{in:t,timeout:200,classNames:{enter:l.default.fadeInEnter,enterActive:l.default.fadeInEnterActive,exit:l.default.fadeInExit,exitActive:l.default.fadeInExitActive},unmountOnExit:!0},r.default.createElement("div",{className:l.default.overlay,role:"presentation"}))}},980:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0,t.default="data:image/svg+xml;charset=utf-8;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg enable-background="new 0 0 944 620" version="1.1" viewBox="0 0 944 620" xml:space="preserve" xmlns="http://www.w3.org/2000/svg">
<style type="text/css">
  .st0{fill:#F63C3D;}
  .st1{fill:#17BAFA;}
  .st2{opacity:0.93;}
  .st3{fill:#18335A;}
  .st4{fill:#D2DA20;}
  .st5{opacity:0.83;}
  .st6{fill:#007165;}
</style>
<path class="st0" d="m558.68 69.77c2.45-2.8 5.82-5.98 10.89-6.67 3.77-0.52 7.15 0.04 9.97 2.66 8.02 7.42 16.31 14.57 23.95 22.37 17.3 17.66 33.04 36.73 48.18 56.28 14.36 18.54 27.69 37.85 40.26 57.7 3.72 5.88 7.51 11.72 11.2 17.62 3.4 5.44 6.75 10.91 10.04 16.41 3.31 5.52 6.52 11.1 9.77 16.66 3 5.12 6.12 10.17 8.96 15.38 4.47 8.2 8.81 16.46 13.07 24.78 3.13 6.12 6.07 12.34 9.05 18.54 3.75 7.81 7.66 15.55 11.12 23.49 3.36 7.72 6.33 15.62 9.31 23.51 2.89 7.66 5.65 15.37 8.32 23.11 0.74 2.16 0.85 4.54 1.46 6.76 1.78 6.5 4.07 12.88 5.43 19.48 1.9 9.21 3.18 18.55 4.63 27.86 0.57 3.63 0.94 7.31 1.26 10.98 0.06 0.72-0.54 1.51-0.84 2.27-0.64-0.6-1.7-1.09-1.86-1.81-1.77-7.92-2.97-16-5.16-23.78-3.17-11.23-6.68-22.38-10.69-33.32-3.75-10.23-8.06-20.27-12.64-30.14-4.69-10.1-9.82-20.01-15.11-29.8-5.29-9.8-10.81-19.47-16.58-28.98-6.61-10.9-13.43-21.68-20.49-32.28-9.59-14.43-19.33-28.76-29.31-42.91-8.46-12-17.17-23.83-26.09-35.47-9.8-12.78-19.77-25.45-30.07-37.83-9.11-10.95-18.56-21.63-28.25-32.05-9.3-9.98-19.07-19.52-28.72-29.17-3.59-3.59-7.57-6.79-11.11-10.43-3.55-3.66-3.52-5.99 0.05-11.22z"/>
<path class="st1" d="m733.08 66.49c3.63-0.83 8.23-1.42 12.74 0.99 3.36 1.8 5.76 4.23 6.51 8.01 2.13 10.72 4.65 21.37 6.26 32.17 3.64 24.45 5.19 49.13 5.97 73.85 0.74 23.44 0.2 46.9-1.28 70.34-0.44 6.95-0.8 13.9-1.28 20.84-0.44 6.4-0.94 12.79-1.5 19.18-0.57 6.41-1.24 12.81-1.87 19.22-0.58 5.9-1.01 11.82-1.77 17.71-1.2 9.26-2.53 18.5-3.96 27.73-1.05 6.79-2.33 13.55-3.56 20.32-1.55 8.52-2.93 17.08-4.79 25.54-1.81 8.22-4.04 16.36-6.26 24.5-2.15 7.9-4.45 15.76-6.83 23.59-0.66 2.18-1.98 4.18-2.79 6.33-2.37 6.31-4.27 12.82-7.04 18.95-3.87 8.57-8.32 16.89-12.61 25.27-1.67 3.27-3.53 6.47-5.42 9.63-0.37 0.62-1.33 0.91-2.02 1.35-0.17-0.86-0.74-1.88-0.45-2.56 3.22-7.45 6.99-14.7 9.78-22.28 4.03-10.95 7.73-22.04 10.91-33.25 2.97-10.48 5.37-21.14 7.46-31.82 2.13-10.93 3.79-21.96 5.26-33 1.47-11.03 2.68-22.11 3.59-33.19 1.04-12.7 1.85-25.43 2.37-38.16 0.7-17.31 1.23-34.63 1.46-51.95 0.19-14.68 0.09-29.37-0.3-44.03-0.43-16.1-1.06-32.21-2.13-48.28-0.95-14.21-2.32-28.4-4.06-42.53-1.66-13.54-3.98-27-6.13-40.47-0.8-5.02-2.15-9.95-2.87-14.97-0.75-5.03 0.65-6.89 6.61-9.03z"/>
<g class="st2">
<path class="st3" d="m433.01 108.31c0.53-3.63 1.63-8.06 5.53-11.36 2.9-2.45 6.05-3.8 9.87-3.16 10.83 1.82 21.75 3.27 32.47 5.61 24.27 5.29 48.01 12.58 71.5 20.6 22.28 7.6 44.11 16.38 65.59 26.02 6.36 2.86 12.76 5.65 19.11 8.54 5.85 2.66 11.67 5.38 17.47 8.16 5.82 2.78 11.59 5.67 17.37 8.51 5.33 2.62 10.74 5.11 15.99 7.88 8.26 4.37 16.46 8.86 24.61 13.43 6 3.37 11.89 6.93 17.8 10.44 7.45 4.43 14.98 8.73 22.26 13.43 7.07 4.57 13.91 9.5 20.75 14.41 6.64 4.77 13.19 9.65 19.69 14.61 1.81 1.38 3.21 3.3 4.94 4.8 5.07 4.41 10.5 8.45 15.26 13.17 6.65 6.58 12.85 13.61 19.18 20.51 2.47 2.7 4.8 5.53 7.08 8.39 0.45 0.56 0.37 1.54 0.54 2.33-0.87-0.15-2.03 0.01-2.56-0.49-5.83-5.59-11.28-11.61-17.4-16.86-8.83-7.57-17.91-14.89-27.28-21.77-8.77-6.43-17.91-12.4-27.19-18.09-9.5-5.82-19.26-11.24-29.09-16.49s-19.79-10.27-29.87-15.03c-11.55-5.45-23.21-10.68-34.98-15.65-16-6.76-32.08-13.36-48.26-19.69-13.71-5.36-27.54-10.45-41.46-15.27-15.28-5.29-30.63-10.4-46.1-15.09-13.69-4.15-27.51-7.9-41.4-11.29-13.32-3.25-26.79-5.88-40.21-8.66-5-1.04-10.11-1.54-15.1-2.65-5.01-1.11-6.26-3.06-6.11-9.29z"/>
</g>
<path class="st4" d="m823.28 220.35c3.56 1.08 7.85 2.85 10.57 7.18 2.02 3.23 2.9 6.53 1.68 10.18-3.46 10.36-6.56 20.86-10.53 31.04-8.97 23.03-19.87 45.23-31.45 67.08-10.99 20.72-23.09 40.82-36.01 60.44-3.83 5.81-7.59 11.67-11.45 17.46-3.56 5.34-7.16 10.64-10.82 15.91-3.67 5.29-7.43 10.51-11.16 15.76-3.43 4.84-6.75 9.76-10.32 14.49-5.63 7.45-11.37 14.81-17.2 22.11-4.28 5.37-8.74 10.61-13.17 15.88-5.57 6.63-11.02 13.38-16.83 19.8-5.65 6.24-11.63 12.2-17.59 18.17-5.78 5.79-11.68 11.47-17.64 17.09-1.66 1.57-3.79 2.64-5.56 4.11-5.19 4.3-10.07 9.01-15.52 12.96-7.61 5.52-15.6 10.53-23.48 15.69-3.08 2.01-6.27 3.87-9.49 5.67-0.63 0.35-1.6 0.13-2.42 0.17 0.28-0.83 0.29-2 0.88-2.44 6.49-4.87 13.36-9.29 19.55-14.5 8.93-7.51 17.65-15.3 25.96-23.46 7.78-7.63 15.15-15.69 22.26-23.93 7.28-8.44 14.19-17.19 20.94-26.04s13.3-17.87 19.59-27.04c7.21-10.51 14.22-21.16 20.99-31.96 9.2-14.68 18.25-29.46 27.04-44.38 7.45-12.65 14.65-25.45 21.58-38.38 7.61-14.2 15.06-28.5 22.1-42.98 6.23-12.81 12.07-25.81 17.57-38.94 5.27-12.58 9.94-25.41 14.76-38.18 1.79-4.75 3.07-9.7 4.93-14.42 1.87-4.72 4.01-5.65 10.24-4.54z"/>
<g class="st5">
<path class="st6" d="m852.54 369.84c1.86 3.22 3.78 7.45 2.79 12.47-0.73 3.74-2.35 6.75-5.74 8.58-9.62 5.18-19.06 10.72-28.92 15.43-22.3 10.66-45.44 19.39-68.84 27.39-22.19 7.59-44.77 13.96-67.62 19.43-6.77 1.62-13.52 3.31-20.3 4.9-6.24 1.46-12.5 2.86-18.77 4.19-6.29 1.34-12.61 2.58-18.92 3.86-5.81 1.18-11.6 2.5-17.45 3.5-9.2 1.58-18.43 3.02-27.67 4.36-6.8 0.99-13.64 1.75-20.47 2.57-8.6 1.02-17.19 2.22-25.83 2.92-8.39 0.68-16.83 0.94-25.26 1.21-8.18 0.26-16.37 0.37-24.56 0.4-2.28 0.01-4.57-0.67-6.87-0.81-6.73-0.42-13.51-0.32-20.19-1.17-9.32-1.18-18.58-2.99-27.86-4.63-3.62-0.64-7.22-1.47-10.79-2.36-0.7-0.17-1.26-1-1.88-1.53 0.77-0.41 1.58-1.26 2.31-1.18 8.06 0.89 16.1 2.36 24.17 2.81 11.65 0.64 23.34 0.92 34.98 0.66 10.89-0.24 21.79-1.07 32.61-2.22 11.08-1.17 22.11-2.83 33.09-4.66s21.92-3.93 32.78-6.31c12.45-2.73 24.86-5.7 37.17-8.94 16.75-4.41 33.47-8.99 50.09-13.86 14.09-4.12 28.1-8.54 42-13.22 15.27-5.14 30.48-10.47 45.52-16.22 13.31-5.08 26.47-10.56 39.46-16.37 12.45-5.57 24.64-11.73 36.89-17.74 4.56-2.24 8.88-4.97 13.47-7.14 4.62-2.18 6.82-1.39 10.61 3.68z"/>
</g>
<circle class="st6" cx="809.09" cy="136.91" r="15.09"/>
<circle class="st3" cx="654.73" cy="35.79" r="15.09"/>
<circle class="st3" cx="486.18" cy="530.81" r="15.09"/>
<circle class="st3" cx="766.76" cy="496.13" r="15.09"/>
<circle class="st4" cx="624.54" cy="500.63" r="15.09"/>
<circle class="st4" cx="501.28" cy="50.88" r="15.09"/>
<circle class="st0" cx="858.6" cy="330.29" r="15.09"/>
<path class="st3" d="m56.96 240.33h67.34c40.02 0 64.9 22.69 64.9 57.1v0.49c0 38.31-30.74 58.32-68.32 58.32h-33.91v54.9h-30.01v-170.81zm64.91 88.82c22.69 0 36.84-12.69 36.84-30.5v-0.49c0-20.01-14.4-30.5-36.84-30.5h-34.9v61.49h34.9z"/>
<path class="st3" d="m219.95 240.33h30.01v143.47h89.79v27.33h-119.8v-170.8z"/>
<path class="st3" d="m352.69 326.22v-0.49c0-48.07 37.09-88.33 89.55-88.33s89.06 39.77 89.06 87.84v0.49c0 48.07-37.09 88.33-89.55 88.33s-89.06-39.77-89.06-87.84zm147.13 0v-0.49c0-33.18-24.16-60.51-58.07-60.51s-57.58 26.84-57.58 60.02v0.49c0 33.18 24.16 60.51 58.07 60.51 33.91 0.01 57.58-26.83 57.58-60.02z"/>
  <path class="st3" d="m554.96 386.25 18.06-21.47c16.35 14.15 32.94 22.2 53.92 22.2 18.54 0 30.26-8.78 30.26-21.47v-0.49c0-12.2-6.83-18.79-38.55-26.11-36.36-8.78-56.85-19.52-56.85-51v-0.49c0-29.28 24.4-49.53 58.32-49.53 24.89 0 44.65 7.56 61.98 21.47l-16.1 22.69c-15.37-11.47-30.74-17.57-46.36-17.57-17.57 0-27.82 9.03-27.82 20.25v0.49c0 13.18 7.81 19.03 40.75 26.84 36.11 8.78 54.66 21.72 54.66 50.02v0.49c0 31.96-25.13 51-61 51-26.13 0.01-50.77-9.02-71.27-27.32z"/>
</svg>"},905:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(413)),i=u(n(141));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,r=e.title,u=e.code,s=e.children,f=e.alwaysOn,d=void 0!==f&&f,p=(t=(0,a.useState)(!1),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),y=p[0],h=p[1],g=d?a.default.createElement("div",{className:o.default.alwaysOnMessage},"Always On"):a.default.createElement(i.default,{onClick:function(e){return function(e,t){"INPUT"===t.target.tagName&&l.default.customize(e,t.target.checked)}(u,e)},defaultChecked:l.default.hasConsented(u)}),m=function(){h(!y)};return a.default.createElement("div",{className:o.default.cookieType},a.default.createElement("div",{className:o.default.switchContainer},a.default.createElement("div",{role:"button",className:o.default.toggleExplanation,onClick:m,onKeyDown:m,tabIndex:0,"aria-label":"Toggle explanation of ".concat(r," Cookies.")},a.default.createElement("span",{className:o.default.toggleIcon},y?"-":"+"),a.default.createElement("strong",{className:o.default.toggleTitle},r)),a.default.createElement("div",{className:o.default.spacer}),g),!!y&&a.default.createElement("div",{className:o.default.explanationContainer},a.default.createElement("div",{className:o.default.toggleIcon}," "),s))}},628:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=s(n(294)),a=n(357),l=s(n(177)),o=s(n(905)),i=s(n(810)),u=s(n(980));function s(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.close,n=e.show;return r.default.createElement(a.CSSTransition,{in:n,timeout:200,classNames:{enter:i.default.slideOutEnter,enterActive:i.default.slideOutEnterActive,exit:i.default.slideOutExit,exitActive:i.default.slideOutExitActive},unmountOnExit:!0},r.default.createElement("div",{className:i.default.slideOut},r.default.createElement("div",{className:i.default.plosLogoWrapper},r.default.createElement("div",null,r.default.createElement("img",{alt:"PLOS Logo",className:i.default.plosLogo,src:u.default})),r.default.createElement("h3",{className:i.default.heading},"Cookie Preference Center")),r.default.createElement("p",{className:i.default.text},"Our website uses different types of cookies. Optional cookies will only be set with your consent and you may withdraw this consent at any time. Below you can learn more about the types of cookies PLOS uses and register your cookie preferences."),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.accept(),t()}},"Accept All Cookies")),r.default.createElement("div",null,r.default.createElement("h3",{className:i.default.customizeHeading},"Customize Your Cookie Preference"),r.default.createElement(o.default,{title:"Strictly Necessary",alwaysOn:!0},"These cookies are necessary to operating the PLOS website. They provide site security, help balance load on our servers, and other essential functions."),r.default.createElement(o.default,{title:"Functional",code:"functionality"},"These cookies and other technologies provide useful site functionality such as remembering your site preferences, allowing you to navigate the PLOS site more efficiently."),r.default.createElement(o.default,{title:"Performance and Analytics",code:"analytics"},"These cookies and other technologies analyze how the PLOS website is accessed, used, and performing in order to maintain and continually improve user experience on the site."),r.default.createElement(o.default,{title:"Marketing",code:"advertising"},"These cookies deliver contextual advertisements on the PLOS site and help third-parties serve you targeted advertisements based on your browsing history.")),r.default.createElement("div",{className:i.default.spacer}),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.hasInteracted()||l.default.reject(),t()}},"Save Selected Preferences and Close")),r.default.createElement("a",{className:i.default.underline,href:"https://plos.org/cookies-policy",target:"_blank",rel:"noreferrer"},"For more information about the cookies and other technologies used by us, please read our Cookie Policy.")))}},141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=o(n(403)),l=o(n(454));function o(e){return e&&e.__esModule?e:{default:e}}function i(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,o=e.defaultChecked,u=e.onClick,s=e.disabled,c=void 0!==s&&s,f="switch"+(t=r.default.useState((0,a.default)()),n=1,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return i(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?i(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}())[0];return r.default.createElement("div",{className:l.default.switch},r.default.createElement("input",{className:l.default.input,disabled:c,id:f,type:"checkbox",defaultChecked:o,onChange:u}),r.default.createElement("label",{className:l.default.paddle,htmlFor:f},r.default.createElement("span",{className:l.default.active},"On"),r.default.createElement("span",{className:l.default.inactive},"Off")))}},403:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var n=0;t.default=function(){return n++}},773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(808))&&r.__esModule?r:{default:r},l=n(773);function o(e){return Object.assign({},...l.VALID_PURPOSES.map((t=>({[t]:e}))))}var i={get:function(){try{const e=JSON.parse(a.default.get(l.COOKIE_KEY));return e?!0===e?o(!0):e:o(!1)}catch(e){return o(!1)}},isSet:function(){return void 0!==a.default.get(l.COOKIE_KEY)},remove:function(){a.default.remove(l.COOKIE_KEY)},set:function(e){const t=window.location.hostname;a.default.set(l.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:l.RECONSENT_INTERVAL})}};t.default=i},177:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(502))&&r.__esModule?r:{default:r},l=n(773);function o(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,a.default.get())}var i={accept:function(){a.default.set(!0),o()},customize:function(e,t){a.default.set(Object.assign(a.default.get(),{[e]:t})),o()},hasConsented:function(e){if(!l.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+l.VALID_PURPOSES.toString());return a.default.get()[e]},hasInteracted:function(){return a.default.isSet()},reject:function(){a.default.set(!1),o()},reset:function(){a.default.remove()},VALID_PURPOSES:l.VALID_PURPOSES};t.default=i},151:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._2w1UwhvJHT_qwQKK4m2Mtf{background-color:#333;bottom:0;left:0;position:fixed;right:0;opacity:.5;top:0;z-index:1}._1y82vgULYYDGyWdjHVia6r{opacity:0}._367_oaFBsPkUkmVR1bGNYm{opacity:.5;transition:opacity 200ms}._2dI2_nwyJPeiTPjhARwALQ{opacity:.5}._2f5ts8uYo0Bpq4XYl7aiJU{opacity:0;transition:opacity 200ms}",""]),a.locals={overlay:"_2w1UwhvJHT_qwQKK4m2Mtf",fadeInEnter:"_1y82vgULYYDGyWdjHVia6r",fadeInEnterActive:"_367_oaFBsPkUkmVR1bGNYm",fadeInExit:"_2dI2_nwyJPeiTPjhARwALQ",fadeInExitActive:"_2f5ts8uYo0Bpq4XYl7aiJU"};const l=a},148:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._3A__ku4NC-f73WZK-2WSLx{flex-grow:1}._2CmoA8p3s0vKIspSCosl9G{cursor:pointer;display:flex;font-weight:bold}._3UCm4aXUK13m4R_iCXSEyn{display:inline-block;flex:0 0 1em}._2qXwuhqwMHjam4FPIz7LCs{flex-shrink:0}.l1QQ8S-nhYCUogSWaE0yF,.s4KCa9TCuz7L8vB3Y0Zto{align-items:center;display:flex;margin-bottom:4px;min-height:32px}._1FFdDFwCKdHcKsmbvSZf6_{margin-right:2px;font-style:italic}",""]),a.locals={spacer:"_3A__ku4NC-f73WZK-2WSLx",toggleExplanation:"_2CmoA8p3s0vKIspSCosl9G",toggleIcon:"_3UCm4aXUK13m4R_iCXSEyn",toggleTitle:"_2qXwuhqwMHjam4FPIz7LCs",switchContainer:"l1QQ8S-nhYCUogSWaE0yF",explanationContainer:"s4KCa9TCuz7L8vB3Y0Zto",alwaysOnMessage:"_1FFdDFwCKdHcKsmbvSZf6_"};const l=a},908:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._1tEo1q2cUK9NIysoJrVPWB{background-color:#fff;bottom:0;color:#1c2e5e;display:flex;flex-direction:column;font-size:14px;max-height:100%;max-width:95%;min-width:320px;padding:16px;position:fixed;overflow-y:auto;top:0;width:25%;z-index:2}.T1Y5lu3DhJYBpNej0XUqn{left:-100vw}._1LboXNkeCnS8lrcYjApaZG{left:0;transition:left 200ms}.M0lj2upZTiu02JJDGvGB{left:0}._3MASX-v6vhk8saSO9VmJ6U{left:-100vw;transition:left 200ms}._28VwqbFjT3AsGRoYLhfgjy{color:#1c2e5e;font-size:20px;font-weight:bold}.xI7u62vIvKFhmZX2xirm- ._28VwqbFjT3AsGRoYLhfgjy{margin-bottom:0}._1rHZW01Wf74DBd08dYWESO{height:40px;margin-right:5px;width:auto}.xI7u62vIvKFhmZX2xirm-{align-items:center;display:flex;flex-direction:row}._369CBb-mfyjgJZcxE85upM{font-size:14px}._1u4ynVnXwZaZEsjTHxtV0v{flex-grow:1}._29PzLWpueUEyRToV1hjZjn{display:flex;flex-wrap:wrap;justify-content:space-around;margin-top:16px;margin-bottom:24px}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn{flex-direction:column}}._29PzLWpueUEyRToV1hjZjn button{background-color:#1c2e5e;border:1px solid #000;border-radius:5px;color:#fff;cursor:pointer;font-size:14px;font-weight:bold;flex-grow:1;padding:8px;white-space:nowrap}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn button~button{margin-top:12px}}@media(min-width: 1501px){._29PzLWpueUEyRToV1hjZjn button~button{margin-left:12px}}.ITkiffnwKKM34XaIHLjB_{color:#1c2e5e;font-size:14px;font-weight:bold}._38RYPxeKGNUF74SufFb2Cn{text-decoration:underline;text-decoration-color:blue}",""]),a.locals={slideOut:"_1tEo1q2cUK9NIysoJrVPWB",slideOutEnter:"T1Y5lu3DhJYBpNej0XUqn",slideOutEnterActive:"_1LboXNkeCnS8lrcYjApaZG",slideOutExit:"M0lj2upZTiu02JJDGvGB",slideOutExitActive:"_3MASX-v6vhk8saSO9VmJ6U",heading:"_28VwqbFjT3AsGRoYLhfgjy",plosLogoWrapper:"xI7u62vIvKFhmZX2xirm-",plosLogo:"_1rHZW01Wf74DBd08dYWESO",text:"_369CBb-mfyjgJZcxE85upM",spacer:"_1u4ynVnXwZaZEsjTHxtV0v",buttonContainer:"_29PzLWpueUEyRToV1hjZjn",customizeHeading:"ITkiffnwKKM34XaIHLjB_",underline:"_38RYPxeKGNUF74SufFb2Cn"};const l=a},174:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,'._2ynah8Lgqwdr9aOADyNLnm{color:#fefefe;font-size:12px;font-weight:bold;height:32px;outline:0;position:relative;user-select:none}._16DjzBVfVPFmQVgTgNlqAD{margin-bottom:0;opacity:0;position:absolute}._2o1hzYk15DlFY9KaHai3O2{background:#cacaca;border-radius:16px;color:inherit;cursor:pointer;display:block;font-weight:inherit;height:32px;position:relative;transition:all .25s ease-out;width:64px}._2o1hzYk15DlFY9KaHai3O2::after{background:#fefefe;border-radius:14px;content:"";display:block;height:24px;left:4px;position:absolute;transform:translate3d(0, 0, 0);transition:all .25s ease-out;top:4px;width:24px}input:checked~._2o1hzYk15DlFY9KaHai3O2::after{left:36px}input:checked~._2o1hzYk15DlFY9KaHai3O2{background:#32a960}._3vFoGG1De0BqwBpqyyWHgM{display:none;left:10%}input:checked+label>._3vFoGG1De0BqwBpqyyWHgM{display:block}._3vFoGG1De0BqwBpqyyWHgM,.KUzu_RflxRcodvteC94f5{position:absolute;transform:translateY(-50%);top:50%}.KUzu_RflxRcodvteC94f5{right:15%}input:checked+label>.KUzu_RflxRcodvteC94f5{display:none}',""]),a.locals={switch:"_2ynah8Lgqwdr9aOADyNLnm",input:"_16DjzBVfVPFmQVgTgNlqAD",paddle:"_2o1hzYk15DlFY9KaHai3O2",active:"_3vFoGG1De0BqwBpqyyWHgM",inactive:"KUzu_RflxRcodvteC94f5"};const l=a},645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n=e(t);return t[2]?"@media ".concat(t[2]," {").concat(n,"}"):n})).join("")},t.i=function(e,n,r){"string"==typeof e&&(e=[[null,e,""]]);var a={};if(r)for(var l=0;l<this.length;l++){var o=this[l][0];null!=o&&(a[o]=!0)}for(var i=0;i<e.length;i++){var u=[].concat(e[i]);r&&a[u[0]]||(n&&(u[2]?u[2]="".concat(n," and ").concat(u[2]):u[2]=n),t.push(u))}},t}},808:(e,t,n)=>{var r,a,l;void 0===(a="function"==typeof(r=l=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var r in n)t[r]=n[r]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(r){function a(){}function l(t,n,l){if("undefined"!=typeof document){"number"==typeof(l=e({path:"/"},a.defaults,l)).expires&&(l.expires=new Date(1*new Date+864e5*l.expires)),l.expires=l.expires?l.expires.toUTCString():"";try{var o=JSON.stringify(n);/^[\{\[]/.test(o)&&(n=o)}catch(e){}n=r.write?r.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var i="";for(var u in l)l[u]&&(i+="; "+u,!0!==l[u]&&(i+="="+l[u].split(";")[0]));return document.cookie=t+"="+n+i}}function o(e,n){if("undefined"!=typeof document){for(var a={},l=document.cookie?document.cookie.split("; "):[],o=0;o<l.length;o++){var i=l[o].split("="),u=i.slice(1).join("=");n||'"'!==u.charAt(0)||(u=u.slice(1,-1));try{var s=t(i[0]);if(u=(r.read||r)(u,s)||t(u),n)try{u=JSON.parse(u)}catch(e){}if(a[s]=u,e===s)break}catch(e){}}return e?a[e]:a}}return a.set=l,a.get=function(e){return o(e,!1)},a.getJSON=function(e){return o(e,!0)},a.remove=function(t,n){l(t,"",e(n,{expires:-1}))},a.defaults={},a.withConverter=n,a}((function(){}))})?r.call(t,n,t,e):r)||(e.exports=a),e.exports=l()},418:e=>{"use strict";var t=Object.getOwnPropertySymbols,n=Object.prototype.hasOwnProperty,r=Object.prototype.propertyIsEnumerable;function a(e){if(null==e)throw new TypeError("Object.assign cannot be called with null or undefined");return Object(e)}e.exports=function(){try{if(!Object.assign)return!1;var e=new String("abc");if(e[5]="de","5"===Object.getOwnPropertyNames(e)[0])return!1;for(var t={},n=0;n<10;n++)t["_"+String.fromCharCode(n)]=n;if("0123456789"!==Object.getOwnPropertyNames(t).map((function(e){return t[e]})).join(""))return!1;var r={};return"abcdefghijklmnopqrst".split("").forEach((function(e){r[e]=e})),"abcdefghijklmnopqrst"===Object.keys(Object.assign({},r)).join("")}catch(e){return!1}}()?Object.assign:function(e,l){for(var o,i,u=a(e),s=1;s<arguments.length;s++){for(var c in o=Object(arguments[s]))n.call(o,c)&&(u[c]=o[c]);if(t){i=t(o);for(var f=0;f<i.length;f++)r.call(o,i[f])&&(u[i[f]]=o[i[f]])}}return u}},448:(e,t,n)=>{"use strict";var r=n(294),a=n(418),l=n(840);function o(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}if(!r)throw Error(o(227));var i=new Set,u={};function s(e,t){c(e,t),c(e+"Capture",t)}function c(e,t){for(u[e]=t,e=0;e<t.length;e++)i.add(t[e])}var f=!("undefined"==typeof window||void 0===window.document||void 0===window.document.createElement),d=/^[:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD][:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD\-.0-9\u00B7\u0300-\u036F\u203F-\u2040]*$/,p=Object.prototype.hasOwnProperty,y={},h={};function g(e,t,n,r,a,l,o){this.acceptsBooleans=2===t||3===t||4===t,this.attributeName=r,this.attributeNamespace=a,this.mustUseProperty=n,this.propertyName=e,this.type=t,this.sanitizeURL=l,this.removeEmptyString=o}var m={};"children dangerouslySetInnerHTML defaultValue defaultChecked innerHTML suppressContentEditableWarning suppressHydrationWarning style".split(" ").forEach((function(e){m[e]=new g(e,0,!1,e,null,!1,!1)})),[["acceptCharset","accept-charset"],["className","class"],["htmlFor","for"],["httpEquiv","http-equiv"]].forEach((function(e){var t=e[0];m[t]=new g(t,1,!1,e[1],null,!1,!1)})),["contentEditable","draggable","spellCheck","value"].forEach((function(e){m[e]=new g(e,2,!1,e.toLowerCase(),null,!1,!1)})),["autoReverse","externalResourcesRequired","focusable","preserveAlpha"].forEach((function(e){m[e]=new g(e,2,!1,e,null,!1,!1)})),"allowFullScreen async autoFocus autoPlay controls default defer disabled disablePictureInPicture disableRemotePlayback formNoValidate hidden loop noModule noValidate open playsInline readOnly required reversed scoped seamless itemScope".split(" ").forEach((function(e){m[e]=new g(e,3,!1,e.toLowerCase(),null,!1,!1)})),["checked","multiple","muted","selected"].forEach((function(e){m[e]=new g(e,3,!0,e,null,!1,!1)})),["capture","download"].forEach((function(e){m[e]=new g(e,4,!1,e,null,!1,!1)})),["cols","rows","size","span"].forEach((function(e){m[e]=new g(e,6,!1,e,null,!1,!1)})),["rowSpan","start"].forEach((function(e){m[e]=new g(e,5,!1,e.toLowerCase(),null,!1,!1)}));var v=/[\-:]([a-z])/g;function b(e){return e[1].toUpperCase()}function M(e,t,n,r){var a=m.hasOwnProperty(t)?m[t]:null;(null!==a?0===a.type:!r&&2<t.length&&("o"===t[0]||"O"===t[0])&&("n"===t[1]||"N"===t[1]))||(function(e,t,n,r){if(null==t||function(e,t,n,r){if(null!==n&&0===n.type)return!1;switch(typeof t){case"function":case"symbol":return!0;case"boolean":return!r&&(null!==n?!n.acceptsBooleans:"data-"!==(e=e.toLowerCase().slice(0,5))&&"aria-"!==e);default:return!1}}(e,t,n,r))return!0;if(r)return!1;if(null!==n)switch(n.type){case 3:return!t;case 4:return!1===t;case 5:return isNaN(t);case 6:return isNaN(t)||1>t}return!1}(t,n,a,r)&&(n=null),r||null===a?function(e){return!!p.call(h,e)||!p.call(y,e)&&(d.test(e)?h[e]=!0:(y[e]=!0,!1))}(t)&&(null===n?e.removeAttribute(t):e.setAttribute(t,""+n)):a.mustUseProperty?e[a.propertyName]=null===n?3!==a.type&&"":n:(t=a.attributeName,r=a.attributeNamespace,null===n?e.removeAttribute(t):(n=3===(a=a.type)||4===a&&!0===n?"":""+n,r?e.setAttributeNS(r,t,n):e.setAttribute(t,n))))}"accent-height alignment-baseline arabic-form baseline-shift cap-height clip-path clip-rule color-interpolation color-interpolation-filters color-profile color-rendering dominant-baseline enable-background fill-opacity fill-rule flood-color flood-opacity font-family font-size font-size-adjust font-stretch font-style font-variant font-weight glyph-name glyph-orientation-horizontal glyph-orientation-vertical horiz-adv-x horiz-origin-x image-rendering letter-spacing lighting-color marker-end marker-mid marker-start overline-position overline-thickness paint-order panose-1 pointer-events rendering-intent shape-rendering stop-color stop-opacity strikethrough-position strikethrough-thickness stroke-dasharray stroke-dashoffset stroke-linecap stroke-linejoin stroke-miterlimit stroke-opacity stroke-width text-anchor text-decoration text-rendering underline-position underline-thickness unicode-bidi unicode-range units-per-em v-alphabetic v-hanging v-ideographic v-mathematical vector-effect vert-adv-y vert-origin-x vert-origin-y word-spacing writing-mode xmlns:xlink x-height".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,null,!1,!1)})),"xlink:actuate xlink:arcrole xlink:role xlink:show xlink:title xlink:type".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/1999/xlink",!1,!1)})),["xml:base","xml:lang","xml:space"].forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/XML/1998/namespace",!1,!1)})),["tabIndex","crossOrigin"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!1,!1)})),m.xlinkHref=new g("xlinkHref",1,!1,"xlink:href","http://www.w3.org/1999/xlink",!0,!1),["src","href","action","formAction"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!0,!0)}));var E=r.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED,L=60103,N=60106,w=60107,S=60108,x=60114,k=60109,j=60110,T=60112,C=60113,I=60120,D=60115,O=60116,z=60121,A=60128,_=60129,P=60130,U=60131;if("function"==typeof Symbol&&Symbol.for){var Y=Symbol.for;L=Y("react.element"),N=Y("react.portal"),w=Y("react.fragment"),S=Y("react.strict_mode"),x=Y("react.profiler"),k=Y("react.provider"),j=Y("react.context"),T=Y("react.forward_ref"),C=Y("react.suspense"),I=Y("react.suspense_list"),D=Y("react.memo"),O=Y("react.lazy"),z=Y("react.block"),Y("react.scope"),A=Y("react.opaque.id"),_=Y("react.debug_trace_mode"),P=Y("react.offscreen"),U=Y("react.legacy_hidden")}var Q,R="function"==typeof Symbol&&Symbol.iterator;function F(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=R&&e[R]||e["@iterator"])?e:null}function V(e){if(void 0===Q)try{throw Error()}catch(e){var t=e.stack.trim().match(/\n( *(at )?)/);Q=t&&t[1]||""}return"\n"+Q+e}var B=!1;function W(e,t){if(!e||B)return"";B=!0;var n=Error.prepareStackTrace;Error.prepareStackTrace=void 0;try{if(t)if(t=function(){throw Error()},Object.defineProperty(t.prototype,"props",{set:function(){throw Error()}}),"object"==typeof Reflect&&Reflect.construct){try{Reflect.construct(t,[])}catch(e){var r=e}Reflect.construct(e,[],t)}else{try{t.call()}catch(e){r=e}e.call(t.prototype)}else{try{throw Error()}catch(e){r=e}e()}}catch(e){if(e&&r&&"string"==typeof e.stack){for(var a=e.stack.split("\n"),l=r.stack.split("\n"),o=a.length-1,i=l.length-1;1<=o&&0<=i&&a[o]!==l[i];)i--;for(;1<=o&&0<=i;o--,i--)if(a[o]!==l[i]){if(1!==o||1!==i)do{if(o--,0>--i||a[o]!==l[i])return"\n"+a[o].replace(" at new "," at ")}while(1<=o&&0<=i);break}}}finally{B=!1,Error.prepareStackTrace=n}return(e=e?e.displayName||e.name:"")?V(e):""}function H(e){switch(e.tag){case 5:return V(e.type);case 16:return V("Lazy");case 13:return V("Suspense");case 19:return V("SuspenseList");case 0:case 2:case 15:return W(e.type,!1);case 11:return W(e.type.render,!1);case 22:return W(e.type._render,!1);case 1:return W(e.type,!0);default:return""}}function K(e){if(null==e)return null;if("function"==typeof e)return e.displayName||e.name||null;if("string"==typeof e)return e;switch(e){case w:return"Fragment";case N:return"Portal";case x:return"Profiler";case S:return"StrictMode";case C:return"Suspense";case I:return"SuspenseList"}if("object"==typeof e)switch(e.$$typeof){case j:return(e.displayName||"Context")+".Consumer";case k:return(e._context.displayName||"Context")+".Provider";case T:var t=e.render;return t=t.displayName||t.name||"",e.displayName||(""!==t?"ForwardRef("+t+")":"ForwardRef");case D:return K(e.type);case z:return K(e._render);case O:t=e._payload,e=e._init;try{return K(e(t))}catch(e){}}return null}function G(e){switch(typeof e){case"boolean":case"number":case"object":case"string":case"undefined":return e;default:return""}}function $(e){var t=e.type;return(e=e.nodeName)&&"input"===e.toLowerCase()&&("checkbox"===t||"radio"===t)}function q(e){e._valueTracker||(e._valueTracker=function(e){var t=$(e)?"checked":"value",n=Object.getOwnPropertyDescriptor(e.constructor.prototype,t),r=""+e[t];if(!e.hasOwnProperty(t)&&void 0!==n&&"function"==typeof n.get&&"function"==typeof n.set){var a=n.get,l=n.set;return Object.defineProperty(e,t,{configurable:!0,get:function(){return a.call(this)},set:function(e){r=""+e,l.call(this,e)}}),Object.defineProperty(e,t,{enumerable:n.enumerable}),{getValue:function(){return r},setValue:function(e){r=""+e},stopTracking:function(){e._valueTracker=null,delete e[t]}}}}(e))}function Z(e){if(!e)return!1;var t=e._valueTracker;if(!t)return!0;var n=t.getValue(),r="";return e&&(r=$(e)?e.checked?"true":"false":e.value),(e=r)!==n&&(t.setValue(e),!0)}function X(e){if(void 0===(e=e||("undefined"!=typeof document?document:void 0)))return null;try{return e.activeElement||e.body}catch(t){return e.body}}function J(e,t){var n=t.checked;return a({},t,{defaultChecked:void 0,defaultValue:void 0,value:void 0,checked:null!=n?n:e._wrapperState.initialChecked})}function ee(e,t){var n=null==t.defaultValue?"":t.defaultValue,r=null!=t.checked?t.checked:t.defaultChecked;n=G(null!=t.value?t.value:n),e._wrapperState={initialChecked:r,initialValue:n,controlled:"checkbox"===t.type||"radio"===t.type?null!=t.checked:null!=t.value}}function te(e,t){null!=(t=t.checked)&&M(e,"checked",t,!1)}function ne(e,t){te(e,t);var n=G(t.value),r=t.type;if(null!=n)"number"===r?(0===n&&""===e.value||e.value!=n)&&(e.value=""+n):e.value!==""+n&&(e.value=""+n);else if("submit"===r||"reset"===r)return void e.removeAttribute("value");t.hasOwnProperty("value")?ae(e,t.type,n):t.hasOwnProperty("defaultValue")&&ae(e,t.type,G(t.defaultValue)),null==t.checked&&null!=t.defaultChecked&&(e.defaultChecked=!!t.defaultChecked)}function re(e,t,n){if(t.hasOwnProperty("value")||t.hasOwnProperty("defaultValue")){var r=t.type;if(!("submit"!==r&&"reset"!==r||void 0!==t.value&&null!==t.value))return;t=""+e._wrapperState.initialValue,n||t===e.value||(e.value=t),e.defaultValue=t}""!==(n=e.name)&&(e.name=""),e.defaultChecked=!!e._wrapperState.initialChecked,""!==n&&(e.name=n)}function ae(e,t,n){"number"===t&&X(e.ownerDocument)===e||(null==n?e.defaultValue=""+e._wrapperState.initialValue:e.defaultValue!==""+n&&(e.defaultValue=""+n))}function le(e,t){return e=a({children:void 0},t),(t=function(e){var t="";return r.Children.forEach(e,(function(e){null!=e&&(t+=e)})),t}(t.children))&&(e.children=t),e}function oe(e,t,n,r){if(e=e.options,t){t={};for(var a=0;a<n.length;a++)t["$"+n[a]]=!0;for(n=0;n<e.length;n++)a=t.hasOwnProperty("$"+e[n].value),e[n].selected!==a&&(e[n].selected=a),a&&r&&(e[n].defaultSelected=!0)}else{for(n=""+G(n),t=null,a=0;a<e.length;a++){if(e[a].value===n)return e[a].selected=!0,void(r&&(e[a].defaultSelected=!0));null!==t||e[a].disabled||(t=e[a])}null!==t&&(t.selected=!0)}}function ie(e,t){if(null!=t.dangerouslySetInnerHTML)throw Error(o(91));return a({},t,{value:void 0,defaultValue:void 0,children:""+e._wrapperState.initialValue})}function ue(e,t){var n=t.value;if(null==n){if(n=t.children,t=t.defaultValue,null!=n){if(null!=t)throw Error(o(92));if(Array.isArray(n)){if(!(1>=n.length))throw Error(o(93));n=n[0]}t=n}null==t&&(t=""),n=t}e._wrapperState={initialValue:G(n)}}function se(e,t){var n=G(t.value),r=G(t.defaultValue);null!=n&&((n=""+n)!==e.value&&(e.value=n),null==t.defaultValue&&e.defaultValue!==n&&(e.defaultValue=n)),null!=r&&(e.defaultValue=""+r)}function ce(e){var t=e.textContent;t===e._wrapperState.initialValue&&""!==t&&null!==t&&(e.value=t)}var fe="http://www.w3.org/1999/xhtml";function de(e){switch(e){case"svg":return"http://www.w3.org/2000/svg";case"math":return"http://www.w3.org/1998/Math/MathML";default:return"http://www.w3.org/1999/xhtml"}}function pe(e,t){return null==e||"http://www.w3.org/1999/xhtml"===e?de(t):"http://www.w3.org/2000/svg"===e&&"foreignObject"===t?"http://www.w3.org/1999/xhtml":e}var ye,he,ge=(he=function(e,t){if("http://www.w3.org/2000/svg"!==e.namespaceURI||"innerHTML"in e)e.innerHTML=t;else{for((ye=ye||document.createElement("div")).innerHTML="<svg>"+t.valueOf().toString()+"</svg>",t=ye.firstChild;e.firstChild;)e.removeChild(e.firstChild);for(;t.firstChild;)e.appendChild(t.firstChild)}},"undefined"!=typeof MSApp&&MSApp.execUnsafeLocalFunction?function(e,t,n,r){MSApp.execUnsafeLocalFunction((function(){return he(e,t)}))}:he);function me(e,t){if(t){var n=e.firstChild;if(n&&n===e.lastChild&&3===n.nodeType)return void(n.nodeValue=t)}e.textContent=t}var ve={animationIterationCount:!0,borderImageOutset:!0,borderImageSlice:!0,borderImageWidth:!0,boxFlex:!0,boxFlexGroup:!0,boxOrdinalGroup:!0,columnCount:!0,columns:!0,flex:!0,flexGrow:!0,flexPositive:!0,flexShrink:!0,flexNegative:!0,flexOrder:!0,gridArea:!0,gridRow:!0,gridRowEnd:!0,gridRowSpan:!0,gridRowStart:!0,gridColumn:!0,gridColumnEnd:!0,gridColumnSpan:!0,gridColumnStart:!0,fontWeight:!0,lineClamp:!0,lineHeight:!0,opacity:!0,order:!0,orphans:!0,tabSize:!0,widows:!0,zIndex:!0,zoom:!0,fillOpacity:!0,floodOpacity:!0,stopOpacity:!0,strokeDasharray:!0,strokeDashoffset:!0,strokeMiterlimit:!0,strokeOpacity:!0,strokeWidth:!0},be=["Webkit","ms","Moz","O"];function Me(e,t,n){return null==t||"boolean"==typeof t||""===t?"":n||"number"!=typeof t||0===t||ve.hasOwnProperty(e)&&ve[e]?(""+t).trim():t+"px"}function Ee(e,t){for(var n in e=e.style,t)if(t.hasOwnProperty(n)){var r=0===n.indexOf("--"),a=Me(n,t[n],r);"float"===n&&(n="cssFloat"),r?e.setProperty(n,a):e[n]=a}}Object.keys(ve).forEach((function(e){be.forEach((function(t){t=t+e.charAt(0).toUpperCase()+e.substring(1),ve[t]=ve[e]}))}));var Le=a({menuitem:!0},{area:!0,base:!0,br:!0,col:!0,embed:!0,hr:!0,img:!0,input:!0,keygen:!0,link:!0,meta:!0,param:!0,source:!0,track:!0,wbr:!0});function Ne(e,t){if(t){if(Le[e]&&(null!=t.children||null!=t.dangerouslySetInnerHTML))throw Error(o(137,e));if(null!=t.dangerouslySetInnerHTML){if(null!=t.children)throw Error(o(60));if("object"!=typeof t.dangerouslySetInnerHTML||!("__html"in t.dangerouslySetInnerHTML))throw Error(o(61))}if(null!=t.style&&"object"!=typeof t.style)throw Error(o(62))}}function we(e,t){if(-1===e.indexOf("-"))return"string"==typeof t.is;switch(e){case"annotation-xml":case"color-profile":case"font-face":case"font-face-src":case"font-face-uri":case"font-face-format":case"font-face-name":case"missing-glyph":return!1;default:return!0}}function Se(e){return(e=e.target||e.srcElement||window).correspondingUseElement&&(e=e.correspondingUseElement),3===e.nodeType?e.parentNode:e}var xe=null,ke=null,je=null;function Te(e){if(e=Jr(e)){if("function"!=typeof xe)throw Error(o(280));var t=e.stateNode;t&&(t=ta(t),xe(e.stateNode,e.type,t))}}function Ce(e){ke?je?je.push(e):je=[e]:ke=e}function Ie(){if(ke){var e=ke,t=je;if(je=ke=null,Te(e),t)for(e=0;e<t.length;e++)Te(t[e])}}function De(e,t){return e(t)}function Oe(e,t,n,r,a){return e(t,n,r,a)}function ze(){}var Ae=De,_e=!1,Pe=!1;function Ue(){null===ke&&null===je||(ze(),Ie())}function Ye(e,t){var n=e.stateNode;if(null===n)return null;var r=ta(n);if(null===r)return null;n=r[t];e:switch(t){case"onClick":case"onClickCapture":case"onDoubleClick":case"onDoubleClickCapture":case"onMouseDown":case"onMouseDownCapture":case"onMouseMove":case"onMouseMoveCapture":case"onMouseUp":case"onMouseUpCapture":case"onMouseEnter":(r=!r.disabled)||(r=!("button"===(e=e.type)||"input"===e||"select"===e||"textarea"===e)),e=!r;break e;default:e=!1}if(e)return null;if(n&&"function"!=typeof n)throw Error(o(231,t,typeof n));return n}var Qe=!1;if(f)try{var Re={};Object.defineProperty(Re,"passive",{get:function(){Qe=!0}}),window.addEventListener("test",Re,Re),window.removeEventListener("test",Re,Re)}catch(he){Qe=!1}function Fe(e,t,n,r,a,l,o,i,u){var s=Array.prototype.slice.call(arguments,3);try{t.apply(n,s)}catch(e){this.onError(e)}}var Ve=!1,Be=null,We=!1,He=null,Ke={onError:function(e){Ve=!0,Be=e}};function Ge(e,t,n,r,a,l,o,i,u){Ve=!1,Be=null,Fe.apply(Ke,arguments)}function $e(e){var t=e,n=e;if(e.alternate)for(;t.return;)t=t.return;else{e=t;do{0!=(1026&(t=e).flags)&&(n=t.return),e=t.return}while(e)}return 3===t.tag?n:null}function qe(e){if(13===e.tag){var t=e.memoizedState;if(null===t&&null!==(e=e.alternate)&&(t=e.memoizedState),null!==t)return t.dehydrated}return null}function Ze(e){if($e(e)!==e)throw Error(o(188))}function Xe(e){if(!(e=function(e){var t=e.alternate;if(!t){if(null===(t=$e(e)))throw Error(o(188));return t!==e?null:e}for(var n=e,r=t;;){var a=n.return;if(null===a)break;var l=a.alternate;if(null===l){if(null!==(r=a.return)){n=r;continue}break}if(a.child===l.child){for(l=a.child;l;){if(l===n)return Ze(a),e;if(l===r)return Ze(a),t;l=l.sibling}throw Error(o(188))}if(n.return!==r.return)n=a,r=l;else{for(var i=!1,u=a.child;u;){if(u===n){i=!0,n=a,r=l;break}if(u===r){i=!0,r=a,n=l;break}u=u.sibling}if(!i){for(u=l.child;u;){if(u===n){i=!0,n=l,r=a;break}if(u===r){i=!0,r=l,n=a;break}u=u.sibling}if(!i)throw Error(o(189))}}if(n.alternate!==r)throw Error(o(190))}if(3!==n.tag)throw Error(o(188));return n.stateNode.current===n?e:t}(e)))return null;for(var t=e;;){if(5===t.tag||6===t.tag)return t;if(t.child)t.child.return=t,t=t.child;else{if(t===e)break;for(;!t.sibling;){if(!t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}}return null}function Je(e,t){for(var n=e.alternate;null!==t;){if(t===e||t===n)return!0;t=t.return}return!1}var et,tt,nt,rt,at=!1,lt=[],ot=null,it=null,ut=null,st=new Map,ct=new Map,ft=[],dt="mousedown mouseup touchcancel touchend touchstart auxclick dblclick pointercancel pointerdown pointerup dragend dragstart drop compositionend compositionstart keydown keypress keyup input textInput copy cut paste click change contextmenu reset submit".split(" ");function pt(e,t,n,r,a){return{blockedOn:e,domEventName:t,eventSystemFlags:16|n,nativeEvent:a,targetContainers:[r]}}function yt(e,t){switch(e){case"focusin":case"focusout":ot=null;break;case"dragenter":case"dragleave":it=null;break;case"mouseover":case"mouseout":ut=null;break;case"pointerover":case"pointerout":st.delete(t.pointerId);break;case"gotpointercapture":case"lostpointercapture":ct.delete(t.pointerId)}}function ht(e,t,n,r,a,l){return null===e||e.nativeEvent!==l?(e=pt(t,n,r,a,l),null!==t&&null!==(t=Jr(t))&&tt(t),e):(e.eventSystemFlags|=r,t=e.targetContainers,null!==a&&-1===t.indexOf(a)&&t.push(a),e)}function gt(e){var t=Xr(e.target);if(null!==t){var n=$e(t);if(null!==n)if(13===(t=n.tag)){if(null!==(t=qe(n)))return e.blockedOn=t,void rt(e.lanePriority,(function(){l.unstable_runWithPriority(e.priority,(function(){nt(n)}))}))}else if(3===t&&n.stateNode.hydrate)return void(e.blockedOn=3===n.tag?n.stateNode.containerInfo:null)}e.blockedOn=null}function mt(e){if(null!==e.blockedOn)return!1;for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n)return null!==(t=Jr(n))&&tt(t),e.blockedOn=n,!1;t.shift()}return!0}function vt(e,t,n){mt(e)&&n.delete(t)}function bt(){for(at=!1;0<lt.length;){var e=lt[0];if(null!==e.blockedOn){null!==(e=Jr(e.blockedOn))&&et(e);break}for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n){e.blockedOn=n;break}t.shift()}null===e.blockedOn&&lt.shift()}null!==ot&&mt(ot)&&(ot=null),null!==it&&mt(it)&&(it=null),null!==ut&&mt(ut)&&(ut=null),st.forEach(vt),ct.forEach(vt)}function Mt(e,t){e.blockedOn===t&&(e.blockedOn=null,at||(at=!0,l.unstable_scheduleCallback(l.unstable_NormalPriority,bt)))}function Et(e){function t(t){return Mt(t,e)}if(0<lt.length){Mt(lt[0],e);for(var n=1;n<lt.length;n++){var r=lt[n];r.blockedOn===e&&(r.blockedOn=null)}}for(null!==ot&&Mt(ot,e),null!==it&&Mt(it,e),null!==ut&&Mt(ut,e),st.forEach(t),ct.forEach(t),n=0;n<ft.length;n++)(r=ft[n]).blockedOn===e&&(r.blockedOn=null);for(;0<ft.length&&null===(n=ft[0]).blockedOn;)gt(n),null===n.blockedOn&&ft.shift()}function Lt(e,t){var n={};return n[e.toLowerCase()]=t.toLowerCase(),n["Webkit"+e]="webkit"+t,n["Moz"+e]="moz"+t,n}var Nt={animationend:Lt("Animation","AnimationEnd"),animationiteration:Lt("Animation","AnimationIteration"),animationstart:Lt("Animation","AnimationStart"),transitionend:Lt("Transition","TransitionEnd")},wt={},St={};function xt(e){if(wt[e])return wt[e];if(!Nt[e])return e;var t,n=Nt[e];for(t in n)if(n.hasOwnProperty(t)&&t in St)return wt[e]=n[t];return e}f&&(St=document.createElement("div").style,"AnimationEvent"in window||(delete Nt.animationend.animation,delete Nt.animationiteration.animation,delete Nt.animationstart.animation),"TransitionEvent"in window||delete Nt.transitionend.transition);var kt=xt("animationend"),jt=xt("animationiteration"),Tt=xt("animationstart"),Ct=xt("transitionend"),It=new Map,Dt=new Map,Ot=["abort","abort",kt,"animationEnd",jt,"animationIteration",Tt,"animationStart","canplay","canPlay","canplaythrough","canPlayThrough","durationchange","durationChange","emptied","emptied","encrypted","encrypted","ended","ended","error","error","gotpointercapture","gotPointerCapture","load","load","loadeddata","loadedData","loadedmetadata","loadedMetadata","loadstart","loadStart","lostpointercapture","lostPointerCapture","playing","playing","progress","progress","seeking","seeking","stalled","stalled","suspend","suspend","timeupdate","timeUpdate",Ct,"transitionEnd","waiting","waiting"];function zt(e,t){for(var n=0;n<e.length;n+=2){var r=e[n],a=e[n+1];a="on"+(a[0].toUpperCase()+a.slice(1)),Dt.set(r,t),It.set(r,a),s(a,[r])}}(0,l.unstable_now)();var At=8;function _t(e){if(0!=(1&e))return At=15,1;if(0!=(2&e))return At=14,2;if(0!=(4&e))return At=13,4;var t=24&e;return 0!==t?(At=12,t):0!=(32&e)?(At=11,32):0!=(t=192&e)?(At=10,t):0!=(256&e)?(At=9,256):0!=(t=3584&e)?(At=8,t):0!=(4096&e)?(At=7,4096):0!=(t=4186112&e)?(At=6,t):0!=(t=62914560&e)?(At=5,t):67108864&e?(At=4,67108864):0!=(134217728&e)?(At=3,134217728):0!=(t=805306368&e)?(At=2,t):0!=(1073741824&e)?(At=1,1073741824):(At=8,e)}function Pt(e,t){var n=e.pendingLanes;if(0===n)return At=0;var r=0,a=0,l=e.expiredLanes,o=e.suspendedLanes,i=e.pingedLanes;if(0!==l)r=l,a=At=15;else if(0!=(l=134217727&n)){var u=l&~o;0!==u?(r=_t(u),a=At):0!=(i&=l)&&(r=_t(i),a=At)}else 0!=(l=n&~o)?(r=_t(l),a=At):0!==i&&(r=_t(i),a=At);if(0===r)return 0;if(r=n&((0>(r=31-Vt(r))?0:1<<r)<<1)-1,0!==t&&t!==r&&0==(t&o)){if(_t(t),a<=At)return t;At=a}if(0!==(t=e.entangledLanes))for(e=e.entanglements,t&=r;0<t;)a=1<<(n=31-Vt(t)),r|=e[n],t&=~a;return r}function Ut(e){return 0!=(e=-1073741825&e.pendingLanes)?e:1073741824&e?1073741824:0}function Yt(e,t){switch(e){case 15:return 1;case 14:return 2;case 12:return 0===(e=Qt(24&~t))?Yt(10,t):e;case 10:return 0===(e=Qt(192&~t))?Yt(8,t):e;case 8:return 0===(e=Qt(3584&~t))&&0===(e=Qt(4186112&~t))&&(e=512),e;case 2:return 0===(t=Qt(805306368&~t))&&(t=268435456),t}throw Error(o(358,e))}function Qt(e){return e&-e}function Rt(e){for(var t=[],n=0;31>n;n++)t.push(e);return t}function Ft(e,t,n){e.pendingLanes|=t;var r=t-1;e.suspendedLanes&=r,e.pingedLanes&=r,(e=e.eventTimes)[t=31-Vt(t)]=n}var Vt=Math.clz32?Math.clz32:function(e){return 0===e?32:31-(Bt(e)/Wt|0)|0},Bt=Math.log,Wt=Math.LN2,Ht=l.unstable_UserBlockingPriority,Kt=l.unstable_runWithPriority,Gt=!0;function $t(e,t,n,r){_e||ze();var a=Zt,l=_e;_e=!0;try{Oe(a,e,t,n,r)}finally{(_e=l)||Ue()}}function qt(e,t,n,r){Kt(Ht,Zt.bind(null,e,t,n,r))}function Zt(e,t,n,r){var a;if(Gt)if((a=0==(4&t))&&0<lt.length&&-1<dt.indexOf(e))e=pt(null,e,t,n,r),lt.push(e);else{var l=Xt(e,t,n,r);if(null===l)a&&yt(e,r);else{if(a){if(-1<dt.indexOf(e))return e=pt(l,e,t,n,r),void lt.push(e);if(function(e,t,n,r,a){switch(t){case"focusin":return ot=ht(ot,e,t,n,r,a),!0;case"dragenter":return it=ht(it,e,t,n,r,a),!0;case"mouseover":return ut=ht(ut,e,t,n,r,a),!0;case"pointerover":var l=a.pointerId;return st.set(l,ht(st.get(l)||null,e,t,n,r,a)),!0;case"gotpointercapture":return l=a.pointerId,ct.set(l,ht(ct.get(l)||null,e,t,n,r,a)),!0}return!1}(l,e,t,n,r))return;yt(e,r)}Ir(e,t,r,null,n)}}}function Xt(e,t,n,r){var a=Se(r);if(null!==(a=Xr(a))){var l=$e(a);if(null===l)a=null;else{var o=l.tag;if(13===o){if(null!==(a=qe(l)))return a;a=null}else if(3===o){if(l.stateNode.hydrate)return 3===l.tag?l.stateNode.containerInfo:null;a=null}else l!==a&&(a=null)}}return Ir(e,t,r,a,n),null}var Jt=null,en=null,tn=null;function nn(){if(tn)return tn;var e,t,n=en,r=n.length,a="value"in Jt?Jt.value:Jt.textContent,l=a.length;for(e=0;e<r&&n[e]===a[e];e++);var o=r-e;for(t=1;t<=o&&n[r-t]===a[l-t];t++);return tn=a.slice(e,1<t?1-t:void 0)}function rn(e){var t=e.keyCode;return"charCode"in e?0===(e=e.charCode)&&13===t&&(e=13):e=t,10===e&&(e=13),32<=e||13===e?e:0}function an(){return!0}function ln(){return!1}function on(e){function t(t,n,r,a,l){for(var o in this._reactName=t,this._targetInst=r,this.type=n,this.nativeEvent=a,this.target=l,this.currentTarget=null,e)e.hasOwnProperty(o)&&(t=e[o],this[o]=t?t(a):a[o]);return this.isDefaultPrevented=(null!=a.defaultPrevented?a.defaultPrevented:!1===a.returnValue)?an:ln,this.isPropagationStopped=ln,this}return a(t.prototype,{preventDefault:function(){this.defaultPrevented=!0;var e=this.nativeEvent;e&&(e.preventDefault?e.preventDefault():"unknown"!=typeof e.returnValue&&(e.returnValue=!1),this.isDefaultPrevented=an)},stopPropagation:function(){var e=this.nativeEvent;e&&(e.stopPropagation?e.stopPropagation():"unknown"!=typeof e.cancelBubble&&(e.cancelBubble=!0),this.isPropagationStopped=an)},persist:function(){},isPersistent:an}),t}var un,sn,cn,fn={eventPhase:0,bubbles:0,cancelable:0,timeStamp:function(e){return e.timeStamp||Date.now()},defaultPrevented:0,isTrusted:0},dn=on(fn),pn=a({},fn,{view:0,detail:0}),yn=on(pn),hn=a({},pn,{screenX:0,screenY:0,clientX:0,clientY:0,pageX:0,pageY:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,getModifierState:xn,button:0,buttons:0,relatedTarget:function(e){return void 0===e.relatedTarget?e.fromElement===e.srcElement?e.toElement:e.fromElement:e.relatedTarget},movementX:function(e){return"movementX"in e?e.movementX:(e!==cn&&(cn&&"mousemove"===e.type?(un=e.screenX-cn.screenX,sn=e.screenY-cn.screenY):sn=un=0,cn=e),un)},movementY:function(e){return"movementY"in e?e.movementY:sn}}),gn=on(hn),mn=on(a({},hn,{dataTransfer:0})),vn=on(a({},pn,{relatedTarget:0})),bn=on(a({},fn,{animationName:0,elapsedTime:0,pseudoElement:0})),Mn=on(a({},fn,{clipboardData:function(e){return"clipboardData"in e?e.clipboardData:window.clipboardData}})),En=on(a({},fn,{data:0})),Ln={Esc:"Escape",Spacebar:" ",Left:"ArrowLeft",Up:"ArrowUp",Right:"ArrowRight",Down:"ArrowDown",Del:"Delete",Win:"OS",Menu:"ContextMenu",Apps:"ContextMenu",Scroll:"ScrollLock",MozPrintableKey:"Unidentified"},Nn={8:"Backspace",9:"Tab",12:"Clear",13:"Enter",16:"Shift",17:"Control",18:"Alt",19:"Pause",20:"CapsLock",27:"Escape",32:" ",33:"PageUp",34:"PageDown",35:"End",36:"Home",37:"ArrowLeft",38:"ArrowUp",39:"ArrowRight",40:"ArrowDown",45:"Insert",46:"Delete",112:"F1",113:"F2",114:"F3",115:"F4",116:"F5",117:"F6",118:"F7",119:"F8",120:"F9",121:"F10",122:"F11",123:"F12",144:"NumLock",145:"ScrollLock",224:"Meta"},wn={Alt:"altKey",Control:"ctrlKey",Meta:"metaKey",Shift:"shiftKey"};function Sn(e){var t=this.nativeEvent;return t.getModifierState?t.getModifierState(e):!!(e=wn[e])&&!!t[e]}function xn(){return Sn}var kn=on(a({},pn,{key:function(e){if(e.key){var t=Ln[e.key]||e.key;if("Unidentified"!==t)return t}return"keypress"===e.type?13===(e=rn(e))?"Enter":String.fromCharCode(e):"keydown"===e.type||"keyup"===e.type?Nn[e.keyCode]||"Unidentified":""},code:0,location:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,repeat:0,locale:0,getModifierState:xn,charCode:function(e){return"keypress"===e.type?rn(e):0},keyCode:function(e){return"keydown"===e.type||"keyup"===e.type?e.keyCode:0},which:function(e){return"keypress"===e.type?rn(e):"keydown"===e.type||"keyup"===e.type?e.keyCode:0}})),jn=on(a({},hn,{pointerId:0,width:0,height:0,pressure:0,tangentialPressure:0,tiltX:0,tiltY:0,twist:0,pointerType:0,isPrimary:0})),Tn=on(a({},pn,{touches:0,targetTouches:0,changedTouches:0,altKey:0,metaKey:0,ctrlKey:0,shiftKey:0,getModifierState:xn})),Cn=on(a({},fn,{propertyName:0,elapsedTime:0,pseudoElement:0})),In=on(a({},hn,{deltaX:function(e){return"deltaX"in e?e.deltaX:"wheelDeltaX"in e?-e.wheelDeltaX:0},deltaY:function(e){return"deltaY"in e?e.deltaY:"wheelDeltaY"in e?-e.wheelDeltaY:"wheelDelta"in e?-e.wheelDelta:0},deltaZ:0,deltaMode:0})),Dn=[9,13,27,32],On=f&&"CompositionEvent"in window,zn=null;f&&"documentMode"in document&&(zn=document.documentMode);var An=f&&"TextEvent"in window&&!zn,_n=f&&(!On||zn&&8<zn&&11>=zn),Pn=String.fromCharCode(32),Un=!1;function Yn(e,t){switch(e){case"keyup":return-1!==Dn.indexOf(t.keyCode);case"keydown":return 229!==t.keyCode;case"keypress":case"mousedown":case"focusout":return!0;default:return!1}}function Qn(e){return"object"==typeof(e=e.detail)&&"data"in e?e.data:null}var Rn=!1,Fn={color:!0,date:!0,datetime:!0,"datetime-local":!0,email:!0,month:!0,number:!0,password:!0,range:!0,search:!0,tel:!0,text:!0,time:!0,url:!0,week:!0};function Vn(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return"input"===t?!!Fn[e.type]:"textarea"===t}function Bn(e,t,n,r){Ce(r),0<(t=Or(t,"onChange")).length&&(n=new dn("onChange","change",null,n,r),e.push({event:n,listeners:t}))}var Wn=null,Hn=null;function Kn(e){Sr(e,0)}function Gn(e){if(Z(ea(e)))return e}function $n(e,t){if("change"===e)return t}var qn=!1;if(f){var Zn;if(f){var Xn="oninput"in document;if(!Xn){var Jn=document.createElement("div");Jn.setAttribute("oninput","return;"),Xn="function"==typeof Jn.oninput}Zn=Xn}else Zn=!1;qn=Zn&&(!document.documentMode||9<document.documentMode)}function er(){Wn&&(Wn.detachEvent("onpropertychange",tr),Hn=Wn=null)}function tr(e){if("value"===e.propertyName&&Gn(Hn)){var t=[];if(Bn(t,Hn,e,Se(e)),e=Kn,_e)e(t);else{_e=!0;try{De(e,t)}finally{_e=!1,Ue()}}}}function nr(e,t,n){"focusin"===e?(er(),Hn=n,(Wn=t).attachEvent("onpropertychange",tr)):"focusout"===e&&er()}function rr(e){if("selectionchange"===e||"keyup"===e||"keydown"===e)return Gn(Hn)}function ar(e,t){if("click"===e)return Gn(t)}function lr(e,t){if("input"===e||"change"===e)return Gn(t)}var or="function"==typeof Object.is?Object.is:function(e,t){return e===t&&(0!==e||1/e==1/t)||e!=e&&t!=t},ir=Object.prototype.hasOwnProperty;function ur(e,t){if(or(e,t))return!0;if("object"!=typeof e||null===e||"object"!=typeof t||null===t)return!1;var n=Object.keys(e),r=Object.keys(t);if(n.length!==r.length)return!1;for(r=0;r<n.length;r++)if(!ir.call(t,n[r])||!or(e[n[r]],t[n[r]]))return!1;return!0}function sr(e){for(;e&&e.firstChild;)e=e.firstChild;return e}function cr(e,t){var n,r=sr(e);for(e=0;r;){if(3===r.nodeType){if(n=e+r.textContent.length,e<=t&&n>=t)return{node:r,offset:t-e};e=n}e:{for(;r;){if(r.nextSibling){r=r.nextSibling;break e}r=r.parentNode}r=void 0}r=sr(r)}}function fr(e,t){return!(!e||!t)&&(e===t||(!e||3!==e.nodeType)&&(t&&3===t.nodeType?fr(e,t.parentNode):"contains"in e?e.contains(t):!!e.compareDocumentPosition&&!!(16&e.compareDocumentPosition(t))))}function dr(){for(var e=window,t=X();t instanceof e.HTMLIFrameElement;){try{var n="string"==typeof t.contentWindow.location.href}catch(e){n=!1}if(!n)break;t=X((e=t.contentWindow).document)}return t}function pr(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return t&&("input"===t&&("text"===e.type||"search"===e.type||"tel"===e.type||"url"===e.type||"password"===e.type)||"textarea"===t||"true"===e.contentEditable)}var yr=f&&"documentMode"in document&&11>=document.documentMode,hr=null,gr=null,mr=null,vr=!1;function br(e,t,n){var r=n.window===n?n.document:9===n.nodeType?n:n.ownerDocument;vr||null==hr||hr!==X(r)||(r="selectionStart"in(r=hr)&&pr(r)?{start:r.selectionStart,end:r.selectionEnd}:{anchorNode:(r=(r.ownerDocument&&r.ownerDocument.defaultView||window).getSelection()).anchorNode,anchorOffset:r.anchorOffset,focusNode:r.focusNode,focusOffset:r.focusOffset},mr&&ur(mr,r)||(mr=r,0<(r=Or(gr,"onSelect")).length&&(t=new dn("onSelect","select",null,t,n),e.push({event:t,listeners:r}),t.target=hr)))}zt("cancel cancel click click close close contextmenu contextMenu copy copy cut cut auxclick auxClick dblclick doubleClick dragend dragEnd dragstart dragStart drop drop focusin focus focusout blur input input invalid invalid keydown keyDown keypress keyPress keyup keyUp mousedown mouseDown mouseup mouseUp paste paste pause pause play play pointercancel pointerCancel pointerdown pointerDown pointerup pointerUp ratechange rateChange reset reset seeked seeked submit submit touchcancel touchCancel touchend touchEnd touchstart touchStart volumechange volumeChange".split(" "),0),zt("drag drag dragenter dragEnter dragexit dragExit dragleave dragLeave dragover dragOver mousemove mouseMove mouseout mouseOut mouseover mouseOver pointermove pointerMove pointerout pointerOut pointerover pointerOver scroll scroll toggle toggle touchmove touchMove wheel wheel".split(" "),1),zt(Ot,2);for(var Mr="change selectionchange textInput compositionstart compositionend compositionupdate".split(" "),Er=0;Er<Mr.length;Er++)Dt.set(Mr[Er],0);c("onMouseEnter",["mouseout","mouseover"]),c("onMouseLeave",["mouseout","mouseover"]),c("onPointerEnter",["pointerout","pointerover"]),c("onPointerLeave",["pointerout","pointerover"]),s("onChange","change click focusin focusout input keydown keyup selectionchange".split(" ")),s("onSelect","focusout contextmenu dragend focusin keydown keyup mousedown mouseup selectionchange".split(" ")),s("onBeforeInput",["compositionend","keypress","textInput","paste"]),s("onCompositionEnd","compositionend focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionStart","compositionstart focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionUpdate","compositionupdate focusout keydown keypress keyup mousedown".split(" "));var Lr="abort canplay canplaythrough durationchange emptied encrypted ended error loadeddata loadedmetadata loadstart pause play playing progress ratechange seeked seeking stalled suspend timeupdate volumechange waiting".split(" "),Nr=new Set("cancel close invalid load scroll toggle".split(" ").concat(Lr));function wr(e,t,n){var r=e.type||"unknown-event";e.currentTarget=n,function(e,t,n,r,a,l,i,u,s){if(Ge.apply(this,arguments),Ve){if(!Ve)throw Error(o(198));var c=Be;Ve=!1,Be=null,We||(We=!0,He=c)}}(r,t,void 0,e),e.currentTarget=null}function Sr(e,t){t=0!=(4&t);for(var n=0;n<e.length;n++){var r=e[n],a=r.event;r=r.listeners;e:{var l=void 0;if(t)for(var o=r.length-1;0<=o;o--){var i=r[o],u=i.instance,s=i.currentTarget;if(i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}else for(o=0;o<r.length;o++){if(u=(i=r[o]).instance,s=i.currentTarget,i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}}}if(We)throw e=He,We=!1,He=null,e}function xr(e,t){var n=na(t),r=e+"__bubble";n.has(r)||(Cr(t,e,2,!1),n.add(r))}var kr="_reactListening"+Math.random().toString(36).slice(2);function jr(e){e[kr]||(e[kr]=!0,i.forEach((function(t){Nr.has(t)||Tr(t,!1,e,null),Tr(t,!0,e,null)})))}function Tr(e,t,n,r){var a=4<arguments.length&&void 0!==arguments[4]?arguments[4]:0,l=n;if("selectionchange"===e&&9!==n.nodeType&&(l=n.ownerDocument),null!==r&&!t&&Nr.has(e)){if("scroll"!==e)return;a|=2,l=r}var o=na(l),i=e+"__"+(t?"capture":"bubble");o.has(i)||(t&&(a|=4),Cr(l,e,a,t),o.add(i))}function Cr(e,t,n,r){var a=Dt.get(t);switch(void 0===a?2:a){case 0:a=$t;break;case 1:a=qt;break;default:a=Zt}n=a.bind(null,t,n,e),a=void 0,!Qe||"touchstart"!==t&&"touchmove"!==t&&"wheel"!==t||(a=!0),r?void 0!==a?e.addEventListener(t,n,{capture:!0,passive:a}):e.addEventListener(t,n,!0):void 0!==a?e.addEventListener(t,n,{passive:a}):e.addEventListener(t,n,!1)}function Ir(e,t,n,r,a){var l=r;if(0==(1&t)&&0==(2&t)&&null!==r)e:for(;;){if(null===r)return;var o=r.tag;if(3===o||4===o){var i=r.stateNode.containerInfo;if(i===a||8===i.nodeType&&i.parentNode===a)break;if(4===o)for(o=r.return;null!==o;){var u=o.tag;if((3===u||4===u)&&((u=o.stateNode.containerInfo)===a||8===u.nodeType&&u.parentNode===a))return;o=o.return}for(;null!==i;){if(null===(o=Xr(i)))return;if(5===(u=o.tag)||6===u){r=l=o;continue e}i=i.parentNode}}r=r.return}!function(e,t,n){if(Pe)return e();Pe=!0;try{Ae(e,t,n)}finally{Pe=!1,Ue()}}((function(){var r=l,a=Se(n),o=[];e:{var i=It.get(e);if(void 0!==i){var u=dn,s=e;switch(e){case"keypress":if(0===rn(n))break e;case"keydown":case"keyup":u=kn;break;case"focusin":s="focus",u=vn;break;case"focusout":s="blur",u=vn;break;case"beforeblur":case"afterblur":u=vn;break;case"click":if(2===n.button)break e;case"auxclick":case"dblclick":case"mousedown":case"mousemove":case"mouseup":case"mouseout":case"mouseover":case"contextmenu":u=gn;break;case"drag":case"dragend":case"dragenter":case"dragexit":case"dragleave":case"dragover":case"dragstart":case"drop":u=mn;break;case"touchcancel":case"touchend":case"touchmove":case"touchstart":u=Tn;break;case kt:case jt:case Tt:u=bn;break;case Ct:u=Cn;break;case"scroll":u=yn;break;case"wheel":u=In;break;case"copy":case"cut":case"paste":u=Mn;break;case"gotpointercapture":case"lostpointercapture":case"pointercancel":case"pointerdown":case"pointermove":case"pointerout":case"pointerover":case"pointerup":u=jn}var c=0!=(4&t),f=!c&&"scroll"===e,d=c?null!==i?i+"Capture":null:i;c=[];for(var p,y=r;null!==y;){var h=(p=y).stateNode;if(5===p.tag&&null!==h&&(p=h,null!==d&&null!=(h=Ye(y,d))&&c.push(Dr(y,h,p))),f)break;y=y.return}0<c.length&&(i=new u(i,s,null,n,a),o.push({event:i,listeners:c}))}}if(0==(7&t)){if(u="mouseout"===e||"pointerout"===e,(!(i="mouseover"===e||"pointerover"===e)||0!=(16&t)||!(s=n.relatedTarget||n.fromElement)||!Xr(s)&&!s[qr])&&(u||i)&&(i=a.window===a?a:(i=a.ownerDocument)?i.defaultView||i.parentWindow:window,u?(u=r,null!==(s=(s=n.relatedTarget||n.toElement)?Xr(s):null)&&(s!==(f=$e(s))||5!==s.tag&&6!==s.tag)&&(s=null)):(u=null,s=r),u!==s)){if(c=gn,h="onMouseLeave",d="onMouseEnter",y="mouse","pointerout"!==e&&"pointerover"!==e||(c=jn,h="onPointerLeave",d="onPointerEnter",y="pointer"),f=null==u?i:ea(u),p=null==s?i:ea(s),(i=new c(h,y+"leave",u,n,a)).target=f,i.relatedTarget=p,h=null,Xr(a)===r&&((c=new c(d,y+"enter",s,n,a)).target=p,c.relatedTarget=f,h=c),f=h,u&&s)e:{for(d=s,y=0,p=c=u;p;p=zr(p))y++;for(p=0,h=d;h;h=zr(h))p++;for(;0<y-p;)c=zr(c),y--;for(;0<p-y;)d=zr(d),p--;for(;y--;){if(c===d||null!==d&&c===d.alternate)break e;c=zr(c),d=zr(d)}c=null}else c=null;null!==u&&Ar(o,i,u,c,!1),null!==s&&null!==f&&Ar(o,f,s,c,!0)}if("select"===(u=(i=r?ea(r):window).nodeName&&i.nodeName.toLowerCase())||"input"===u&&"file"===i.type)var g=$n;else if(Vn(i))if(qn)g=lr;else{g=rr;var m=nr}else(u=i.nodeName)&&"input"===u.toLowerCase()&&("checkbox"===i.type||"radio"===i.type)&&(g=ar);switch(g&&(g=g(e,r))?Bn(o,g,n,a):(m&&m(e,i,r),"focusout"===e&&(m=i._wrapperState)&&m.controlled&&"number"===i.type&&ae(i,"number",i.value)),m=r?ea(r):window,e){case"focusin":(Vn(m)||"true"===m.contentEditable)&&(hr=m,gr=r,mr=null);break;case"focusout":mr=gr=hr=null;break;case"mousedown":vr=!0;break;case"contextmenu":case"mouseup":case"dragend":vr=!1,br(o,n,a);break;case"selectionchange":if(yr)break;case"keydown":case"keyup":br(o,n,a)}var v;if(On)e:{switch(e){case"compositionstart":var b="onCompositionStart";break e;case"compositionend":b="onCompositionEnd";break e;case"compositionupdate":b="onCompositionUpdate";break e}b=void 0}else Rn?Yn(e,n)&&(b="onCompositionEnd"):"keydown"===e&&229===n.keyCode&&(b="onCompositionStart");b&&(_n&&"ko"!==n.locale&&(Rn||"onCompositionStart"!==b?"onCompositionEnd"===b&&Rn&&(v=nn()):(en="value"in(Jt=a)?Jt.value:Jt.textContent,Rn=!0)),0<(m=Or(r,b)).length&&(b=new En(b,e,null,n,a),o.push({event:b,listeners:m}),(v||null!==(v=Qn(n)))&&(b.data=v))),(v=An?function(e,t){switch(e){case"compositionend":return Qn(t);case"keypress":return 32!==t.which?null:(Un=!0,Pn);case"textInput":return(e=t.data)===Pn&&Un?null:e;default:return null}}(e,n):function(e,t){if(Rn)return"compositionend"===e||!On&&Yn(e,t)?(e=nn(),tn=en=Jt=null,Rn=!1,e):null;switch(e){case"paste":return null;case"keypress":if(!(t.ctrlKey||t.altKey||t.metaKey)||t.ctrlKey&&t.altKey){if(t.char&&1<t.char.length)return t.char;if(t.which)return String.fromCharCode(t.which)}return null;case"compositionend":return _n&&"ko"!==t.locale?null:t.data;default:return null}}(e,n))&&0<(r=Or(r,"onBeforeInput")).length&&(a=new En("onBeforeInput","beforeinput",null,n,a),o.push({event:a,listeners:r}),a.data=v)}Sr(o,t)}))}function Dr(e,t,n){return{instance:e,listener:t,currentTarget:n}}function Or(e,t){for(var n=t+"Capture",r=[];null!==e;){var a=e,l=a.stateNode;5===a.tag&&null!==l&&(a=l,null!=(l=Ye(e,n))&&r.unshift(Dr(e,l,a)),null!=(l=Ye(e,t))&&r.push(Dr(e,l,a))),e=e.return}return r}function zr(e){if(null===e)return null;do{e=e.return}while(e&&5!==e.tag);return e||null}function Ar(e,t,n,r,a){for(var l=t._reactName,o=[];null!==n&&n!==r;){var i=n,u=i.alternate,s=i.stateNode;if(null!==u&&u===r)break;5===i.tag&&null!==s&&(i=s,a?null!=(u=Ye(n,l))&&o.unshift(Dr(n,u,i)):a||null!=(u=Ye(n,l))&&o.push(Dr(n,u,i))),n=n.return}0!==o.length&&e.push({event:t,listeners:o})}function _r(){}var Pr=null,Ur=null;function Yr(e,t){switch(e){case"button":case"input":case"select":case"textarea":return!!t.autoFocus}return!1}function Qr(e,t){return"textarea"===e||"option"===e||"noscript"===e||"string"==typeof t.children||"number"==typeof t.children||"object"==typeof t.dangerouslySetInnerHTML&&null!==t.dangerouslySetInnerHTML&&null!=t.dangerouslySetInnerHTML.__html}var Rr="function"==typeof setTimeout?setTimeout:void 0,Fr="function"==typeof clearTimeout?clearTimeout:void 0;function Vr(e){(1===e.nodeType||9===e.nodeType&&null!=(e=e.body))&&(e.textContent="")}function Br(e){for(;null!=e;e=e.nextSibling){var t=e.nodeType;if(1===t||3===t)break}return e}function Wr(e){e=e.previousSibling;for(var t=0;e;){if(8===e.nodeType){var n=e.data;if("$"===n||"$!"===n||"$?"===n){if(0===t)return e;t--}else"/$"===n&&t++}e=e.previousSibling}return null}var Hr=0,Kr=Math.random().toString(36).slice(2),Gr="__reactFiber$"+Kr,$r="__reactProps$"+Kr,qr="__reactContainer$"+Kr,Zr="__reactEvents$"+Kr;function Xr(e){var t=e[Gr];if(t)return t;for(var n=e.parentNode;n;){if(t=n[qr]||n[Gr]){if(n=t.alternate,null!==t.child||null!==n&&null!==n.child)for(e=Wr(e);null!==e;){if(n=e[Gr])return n;e=Wr(e)}return t}n=(e=n).parentNode}return null}function Jr(e){return!(e=e[Gr]||e[qr])||5!==e.tag&&6!==e.tag&&13!==e.tag&&3!==e.tag?null:e}function ea(e){if(5===e.tag||6===e.tag)return e.stateNode;throw Error(o(33))}function ta(e){return e[$r]||null}function na(e){var t=e[Zr];return void 0===t&&(t=e[Zr]=new Set),t}var ra=[],aa=-1;function la(e){return{current:e}}function oa(e){0>aa||(e.current=ra[aa],ra[aa]=null,aa--)}function ia(e,t){aa++,ra[aa]=e.current,e.current=t}var ua={},sa=la(ua),ca=la(!1),fa=ua;function da(e,t){var n=e.type.contextTypes;if(!n)return ua;var r=e.stateNode;if(r&&r.__reactInternalMemoizedUnmaskedChildContext===t)return r.__reactInternalMemoizedMaskedChildContext;var a,l={};for(a in n)l[a]=t[a];return r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=t,e.__reactInternalMemoizedMaskedChildContext=l),l}function pa(e){return null!=e.childContextTypes}function ya(){oa(ca),oa(sa)}function ha(e,t,n){if(sa.current!==ua)throw Error(o(168));ia(sa,t),ia(ca,n)}function ga(e,t,n){var r=e.stateNode;if(e=t.childContextTypes,"function"!=typeof r.getChildContext)return n;for(var l in r=r.getChildContext())if(!(l in e))throw Error(o(108,K(t)||"Unknown",l));return a({},n,r)}function ma(e){return e=(e=e.stateNode)&&e.__reactInternalMemoizedMergedChildContext||ua,fa=sa.current,ia(sa,e),ia(ca,ca.current),!0}function va(e,t,n){var r=e.stateNode;if(!r)throw Error(o(169));n?(e=ga(e,t,fa),r.__reactInternalMemoizedMergedChildContext=e,oa(ca),oa(sa),ia(sa,e)):oa(ca),ia(ca,n)}var ba=null,Ma=null,Ea=l.unstable_runWithPriority,La=l.unstable_scheduleCallback,Na=l.unstable_cancelCallback,wa=l.unstable_shouldYield,Sa=l.unstable_requestPaint,xa=l.unstable_now,ka=l.unstable_getCurrentPriorityLevel,ja=l.unstable_ImmediatePriority,Ta=l.unstable_UserBlockingPriority,Ca=l.unstable_NormalPriority,Ia=l.unstable_LowPriority,Da=l.unstable_IdlePriority,Oa={},za=void 0!==Sa?Sa:function(){},Aa=null,_a=null,Pa=!1,Ua=xa(),Ya=1e4>Ua?xa:function(){return xa()-Ua};function Qa(){switch(ka()){case ja:return 99;case Ta:return 98;case Ca:return 97;case Ia:return 96;case Da:return 95;default:throw Error(o(332))}}function Ra(e){switch(e){case 99:return ja;case 98:return Ta;case 97:return Ca;case 96:return Ia;case 95:return Da;default:throw Error(o(332))}}function Fa(e,t){return e=Ra(e),Ea(e,t)}function Va(e,t,n){return e=Ra(e),La(e,t,n)}function Ba(){if(null!==_a){var e=_a;_a=null,Na(e)}Wa()}function Wa(){if(!Pa&&null!==Aa){Pa=!0;var e=0;try{var t=Aa;Fa(99,(function(){for(;e<t.length;e++){var n=t[e];do{n=n(!0)}while(null!==n)}})),Aa=null}catch(t){throw null!==Aa&&(Aa=Aa.slice(e+1)),La(ja,Ba),t}finally{Pa=!1}}}var Ha=E.ReactCurrentBatchConfig;function Ka(e,t){if(e&&e.defaultProps){for(var n in t=a({},t),e=e.defaultProps)void 0===t[n]&&(t[n]=e[n]);return t}return t}var Ga=la(null),$a=null,qa=null,Za=null;function Xa(){Za=qa=$a=null}function Ja(e){var t=Ga.current;oa(Ga),e.type._context._currentValue=t}function el(e,t){for(;null!==e;){var n=e.alternate;if((e.childLanes&t)===t){if(null===n||(n.childLanes&t)===t)break;n.childLanes|=t}else e.childLanes|=t,null!==n&&(n.childLanes|=t);e=e.return}}function tl(e,t){$a=e,Za=qa=null,null!==(e=e.dependencies)&&null!==e.firstContext&&(0!=(e.lanes&t)&&(Oo=!0),e.firstContext=null)}function nl(e,t){if(Za!==e&&!1!==t&&0!==t)if("number"==typeof t&&1073741823!==t||(Za=e,t=1073741823),t={context:e,observedBits:t,next:null},null===qa){if(null===$a)throw Error(o(308));qa=t,$a.dependencies={lanes:0,firstContext:t,responders:null}}else qa=qa.next=t;return e._currentValue}var rl=!1;function al(e){e.updateQueue={baseState:e.memoizedState,firstBaseUpdate:null,lastBaseUpdate:null,shared:{pending:null},effects:null}}function ll(e,t){e=e.updateQueue,t.updateQueue===e&&(t.updateQueue={baseState:e.baseState,firstBaseUpdate:e.firstBaseUpdate,lastBaseUpdate:e.lastBaseUpdate,shared:e.shared,effects:e.effects})}function ol(e,t){return{eventTime:e,lane:t,tag:0,payload:null,callback:null,next:null}}function il(e,t){if(null!==(e=e.updateQueue)){var n=(e=e.shared).pending;null===n?t.next=t:(t.next=n.next,n.next=t),e.pending=t}}function ul(e,t){var n=e.updateQueue,r=e.alternate;if(null!==r&&n===(r=r.updateQueue)){var a=null,l=null;if(null!==(n=n.firstBaseUpdate)){do{var o={eventTime:n.eventTime,lane:n.lane,tag:n.tag,payload:n.payload,callback:n.callback,next:null};null===l?a=l=o:l=l.next=o,n=n.next}while(null!==n);null===l?a=l=t:l=l.next=t}else a=l=t;return n={baseState:r.baseState,firstBaseUpdate:a,lastBaseUpdate:l,shared:r.shared,effects:r.effects},void(e.updateQueue=n)}null===(e=n.lastBaseUpdate)?n.firstBaseUpdate=t:e.next=t,n.lastBaseUpdate=t}function sl(e,t,n,r){var l=e.updateQueue;rl=!1;var o=l.firstBaseUpdate,i=l.lastBaseUpdate,u=l.shared.pending;if(null!==u){l.shared.pending=null;var s=u,c=s.next;s.next=null,null===i?o=c:i.next=c,i=s;var f=e.alternate;if(null!==f){var d=(f=f.updateQueue).lastBaseUpdate;d!==i&&(null===d?f.firstBaseUpdate=c:d.next=c,f.lastBaseUpdate=s)}}if(null!==o){for(d=l.baseState,i=0,f=c=s=null;;){u=o.lane;var p=o.eventTime;if((r&u)===u){null!==f&&(f=f.next={eventTime:p,lane:0,tag:o.tag,payload:o.payload,callback:o.callback,next:null});e:{var y=e,h=o;switch(u=t,p=n,h.tag){case 1:if("function"==typeof(y=h.payload)){d=y.call(p,d,u);break e}d=y;break e;case 3:y.flags=-4097&y.flags|64;case 0:if(null==(u="function"==typeof(y=h.payload)?y.call(p,d,u):y))break e;d=a({},d,u);break e;case 2:rl=!0}}null!==o.callback&&(e.flags|=32,null===(u=l.effects)?l.effects=[o]:u.push(o))}else p={eventTime:p,lane:u,tag:o.tag,payload:o.payload,callback:o.callback,next:null},null===f?(c=f=p,s=d):f=f.next=p,i|=u;if(null===(o=o.next)){if(null===(u=l.shared.pending))break;o=u.next,u.next=null,l.lastBaseUpdate=u,l.shared.pending=null}}null===f&&(s=d),l.baseState=s,l.firstBaseUpdate=c,l.lastBaseUpdate=f,Ai|=i,e.lanes=i,e.memoizedState=d}}function cl(e,t,n){if(e=t.effects,t.effects=null,null!==e)for(t=0;t<e.length;t++){var r=e[t],a=r.callback;if(null!==a){if(r.callback=null,r=n,"function"!=typeof a)throw Error(o(191,a));a.call(r)}}}var fl=(new r.Component).refs;function dl(e,t,n,r){n=null==(n=n(r,t=e.memoizedState))?t:a({},t,n),e.memoizedState=n,0===e.lanes&&(e.updateQueue.baseState=n)}var pl={isMounted:function(e){return!!(e=e._reactInternals)&&$e(e)===e},enqueueSetState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueReplaceState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.tag=1,l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueForceUpdate:function(e,t){e=e._reactInternals;var n=ou(),r=iu(e),a=ol(n,r);a.tag=2,null!=t&&(a.callback=t),il(e,a),uu(e,r,n)}};function yl(e,t,n,r,a,l,o){return"function"==typeof(e=e.stateNode).shouldComponentUpdate?e.shouldComponentUpdate(r,l,o):!(t.prototype&&t.prototype.isPureReactComponent&&ur(n,r)&&ur(a,l))}function hl(e,t,n){var r=!1,a=ua,l=t.contextType;return"object"==typeof l&&null!==l?l=nl(l):(a=pa(t)?fa:sa.current,l=(r=null!=(r=t.contextTypes))?da(e,a):ua),t=new t(n,l),e.memoizedState=null!==t.state&&void 0!==t.state?t.state:null,t.updater=pl,e.stateNode=t,t._reactInternals=e,r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=a,e.__reactInternalMemoizedMaskedChildContext=l),t}function gl(e,t,n,r){e=t.state,"function"==typeof t.componentWillReceiveProps&&t.componentWillReceiveProps(n,r),"function"==typeof t.UNSAFE_componentWillReceiveProps&&t.UNSAFE_componentWillReceiveProps(n,r),t.state!==e&&pl.enqueueReplaceState(t,t.state,null)}function ml(e,t,n,r){var a=e.stateNode;a.props=n,a.state=e.memoizedState,a.refs=fl,al(e);var l=t.contextType;"object"==typeof l&&null!==l?a.context=nl(l):(l=pa(t)?fa:sa.current,a.context=da(e,l)),sl(e,n,a,r),a.state=e.memoizedState,"function"==typeof(l=t.getDerivedStateFromProps)&&(dl(e,t,l,n),a.state=e.memoizedState),"function"==typeof t.getDerivedStateFromProps||"function"==typeof a.getSnapshotBeforeUpdate||"function"!=typeof a.UNSAFE_componentWillMount&&"function"!=typeof a.componentWillMount||(t=a.state,"function"==typeof a.componentWillMount&&a.componentWillMount(),"function"==typeof a.UNSAFE_componentWillMount&&a.UNSAFE_componentWillMount(),t!==a.state&&pl.enqueueReplaceState(a,a.state,null),sl(e,n,a,r),a.state=e.memoizedState),"function"==typeof a.componentDidMount&&(e.flags|=4)}var vl=Array.isArray;function bl(e,t,n){if(null!==(e=n.ref)&&"function"!=typeof e&&"object"!=typeof e){if(n._owner){if(n=n._owner){if(1!==n.tag)throw Error(o(309));var r=n.stateNode}if(!r)throw Error(o(147,e));var a=""+e;return null!==t&&null!==t.ref&&"function"==typeof t.ref&&t.ref._stringRef===a?t.ref:((t=function(e){var t=r.refs;t===fl&&(t=r.refs={}),null===e?delete t[a]:t[a]=e})._stringRef=a,t)}if("string"!=typeof e)throw Error(o(284));if(!n._owner)throw Error(o(290,e))}return e}function Ml(e,t){if("textarea"!==e.type)throw Error(o(31,"[object Object]"===Object.prototype.toString.call(t)?"object with keys {"+Object.keys(t).join(", ")+"}":t))}function El(e){function t(t,n){if(e){var r=t.lastEffect;null!==r?(r.nextEffect=n,t.lastEffect=n):t.firstEffect=t.lastEffect=n,n.nextEffect=null,n.flags=8}}function n(n,r){if(!e)return null;for(;null!==r;)t(n,r),r=r.sibling;return null}function r(e,t){for(e=new Map;null!==t;)null!==t.key?e.set(t.key,t):e.set(t.index,t),t=t.sibling;return e}function a(e,t){return(e=Qu(e,t)).index=0,e.sibling=null,e}function l(t,n,r){return t.index=r,e?null!==(r=t.alternate)?(r=r.index)<n?(t.flags=2,n):r:(t.flags=2,n):n}function i(t){return e&&null===t.alternate&&(t.flags=2),t}function u(e,t,n,r){return null===t||6!==t.tag?((t=Bu(n,e.mode,r)).return=e,t):((t=a(t,n)).return=e,t)}function s(e,t,n,r){return null!==t&&t.elementType===n.type?((r=a(t,n.props)).ref=bl(e,t,n),r.return=e,r):((r=Ru(n.type,n.key,n.props,null,e.mode,r)).ref=bl(e,t,n),r.return=e,r)}function c(e,t,n,r){return null===t||4!==t.tag||t.stateNode.containerInfo!==n.containerInfo||t.stateNode.implementation!==n.implementation?((t=Wu(n,e.mode,r)).return=e,t):((t=a(t,n.children||[])).return=e,t)}function f(e,t,n,r,l){return null===t||7!==t.tag?((t=Fu(n,e.mode,r,l)).return=e,t):((t=a(t,n)).return=e,t)}function d(e,t,n){if("string"==typeof t||"number"==typeof t)return(t=Bu(""+t,e.mode,n)).return=e,t;if("object"==typeof t&&null!==t){switch(t.$$typeof){case L:return(n=Ru(t.type,t.key,t.props,null,e.mode,n)).ref=bl(e,null,t),n.return=e,n;case N:return(t=Wu(t,e.mode,n)).return=e,t}if(vl(t)||F(t))return(t=Fu(t,e.mode,n,null)).return=e,t;Ml(e,t)}return null}function p(e,t,n,r){var a=null!==t?t.key:null;if("string"==typeof n||"number"==typeof n)return null!==a?null:u(e,t,""+n,r);if("object"==typeof n&&null!==n){switch(n.$$typeof){case L:return n.key===a?n.type===w?f(e,t,n.props.children,r,a):s(e,t,n,r):null;case N:return n.key===a?c(e,t,n,r):null}if(vl(n)||F(n))return null!==a?null:f(e,t,n,r,null);Ml(e,n)}return null}function y(e,t,n,r,a){if("string"==typeof r||"number"==typeof r)return u(t,e=e.get(n)||null,""+r,a);if("object"==typeof r&&null!==r){switch(r.$$typeof){case L:return e=e.get(null===r.key?n:r.key)||null,r.type===w?f(t,e,r.props.children,a,r.key):s(t,e,r,a);case N:return c(t,e=e.get(null===r.key?n:r.key)||null,r,a)}if(vl(r)||F(r))return f(t,e=e.get(n)||null,r,a,null);Ml(t,r)}return null}function h(a,o,i,u){for(var s=null,c=null,f=o,h=o=0,g=null;null!==f&&h<i.length;h++){f.index>h?(g=f,f=null):g=f.sibling;var m=p(a,f,i[h],u);if(null===m){null===f&&(f=g);break}e&&f&&null===m.alternate&&t(a,f),o=l(m,o,h),null===c?s=m:c.sibling=m,c=m,f=g}if(h===i.length)return n(a,f),s;if(null===f){for(;h<i.length;h++)null!==(f=d(a,i[h],u))&&(o=l(f,o,h),null===c?s=f:c.sibling=f,c=f);return s}for(f=r(a,f);h<i.length;h++)null!==(g=y(f,a,h,i[h],u))&&(e&&null!==g.alternate&&f.delete(null===g.key?h:g.key),o=l(g,o,h),null===c?s=g:c.sibling=g,c=g);return e&&f.forEach((function(e){return t(a,e)})),s}function g(a,i,u,s){var c=F(u);if("function"!=typeof c)throw Error(o(150));if(null==(u=c.call(u)))throw Error(o(151));for(var f=c=null,h=i,g=i=0,m=null,v=u.next();null!==h&&!v.done;g++,v=u.next()){h.index>g?(m=h,h=null):m=h.sibling;var b=p(a,h,v.value,s);if(null===b){null===h&&(h=m);break}e&&h&&null===b.alternate&&t(a,h),i=l(b,i,g),null===f?c=b:f.sibling=b,f=b,h=m}if(v.done)return n(a,h),c;if(null===h){for(;!v.done;g++,v=u.next())null!==(v=d(a,v.value,s))&&(i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return c}for(h=r(a,h);!v.done;g++,v=u.next())null!==(v=y(h,a,g,v.value,s))&&(e&&null!==v.alternate&&h.delete(null===v.key?g:v.key),i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return e&&h.forEach((function(e){return t(a,e)})),c}return function(e,r,l,u){var s="object"==typeof l&&null!==l&&l.type===w&&null===l.key;s&&(l=l.props.children);var c="object"==typeof l&&null!==l;if(c)switch(l.$$typeof){case L:e:{for(c=l.key,s=r;null!==s;){if(s.key===c){switch(s.tag){case 7:if(l.type===w){n(e,s.sibling),(r=a(s,l.props.children)).return=e,e=r;break e}break;default:if(s.elementType===l.type){n(e,s.sibling),(r=a(s,l.props)).ref=bl(e,s,l),r.return=e,e=r;break e}}n(e,s);break}t(e,s),s=s.sibling}l.type===w?((r=Fu(l.props.children,e.mode,u,l.key)).return=e,e=r):((u=Ru(l.type,l.key,l.props,null,e.mode,u)).ref=bl(e,r,l),u.return=e,e=u)}return i(e);case N:e:{for(s=l.key;null!==r;){if(r.key===s){if(4===r.tag&&r.stateNode.containerInfo===l.containerInfo&&r.stateNode.implementation===l.implementation){n(e,r.sibling),(r=a(r,l.children||[])).return=e,e=r;break e}n(e,r);break}t(e,r),r=r.sibling}(r=Wu(l,e.mode,u)).return=e,e=r}return i(e)}if("string"==typeof l||"number"==typeof l)return l=""+l,null!==r&&6===r.tag?(n(e,r.sibling),(r=a(r,l)).return=e,e=r):(n(e,r),(r=Bu(l,e.mode,u)).return=e,e=r),i(e);if(vl(l))return h(e,r,l,u);if(F(l))return g(e,r,l,u);if(c&&Ml(e,l),void 0===l&&!s)switch(e.tag){case 1:case 22:case 0:case 11:case 15:throw Error(o(152,K(e.type)||"Component"))}return n(e,r)}}var Ll=El(!0),Nl=El(!1),wl={},Sl=la(wl),xl=la(wl),kl=la(wl);function jl(e){if(e===wl)throw Error(o(174));return e}function Tl(e,t){switch(ia(kl,t),ia(xl,e),ia(Sl,wl),e=t.nodeType){case 9:case 11:t=(t=t.documentElement)?t.namespaceURI:pe(null,"");break;default:t=pe(t=(e=8===e?t.parentNode:t).namespaceURI||null,e=e.tagName)}oa(Sl),ia(Sl,t)}function Cl(){oa(Sl),oa(xl),oa(kl)}function Il(e){jl(kl.current);var t=jl(Sl.current),n=pe(t,e.type);t!==n&&(ia(xl,e),ia(Sl,n))}function Dl(e){xl.current===e&&(oa(Sl),oa(xl))}var Ol=la(0);function zl(e){for(var t=e;null!==t;){if(13===t.tag){var n=t.memoizedState;if(null!==n&&(null===(n=n.dehydrated)||"$?"===n.data||"$!"===n.data))return t}else if(19===t.tag&&void 0!==t.memoizedProps.revealOrder){if(0!=(64&t.flags))return t}else if(null!==t.child){t.child.return=t,t=t.child;continue}if(t===e)break;for(;null===t.sibling;){if(null===t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}return null}var Al=null,_l=null,Pl=!1;function Ul(e,t){var n=Uu(5,null,null,0);n.elementType="DELETED",n.type="DELETED",n.stateNode=t,n.return=e,n.flags=8,null!==e.lastEffect?(e.lastEffect.nextEffect=n,e.lastEffect=n):e.firstEffect=e.lastEffect=n}function Yl(e,t){switch(e.tag){case 5:var n=e.type;return null!==(t=1!==t.nodeType||n.toLowerCase()!==t.nodeName.toLowerCase()?null:t)&&(e.stateNode=t,!0);case 6:return null!==(t=""===e.pendingProps||3!==t.nodeType?null:t)&&(e.stateNode=t,!0);case 13:default:return!1}}function Ql(e){if(Pl){var t=_l;if(t){var n=t;if(!Yl(e,t)){if(!(t=Br(n.nextSibling))||!Yl(e,t))return e.flags=-1025&e.flags|2,Pl=!1,void(Al=e);Ul(Al,n)}Al=e,_l=Br(t.firstChild)}else e.flags=-1025&e.flags|2,Pl=!1,Al=e}}function Rl(e){for(e=e.return;null!==e&&5!==e.tag&&3!==e.tag&&13!==e.tag;)e=e.return;Al=e}function Fl(e){if(e!==Al)return!1;if(!Pl)return Rl(e),Pl=!0,!1;var t=e.type;if(5!==e.tag||"head"!==t&&"body"!==t&&!Qr(t,e.memoizedProps))for(t=_l;t;)Ul(e,t),t=Br(t.nextSibling);if(Rl(e),13===e.tag){if(!(e=null!==(e=e.memoizedState)?e.dehydrated:null))throw Error(o(317));e:{for(e=e.nextSibling,t=0;e;){if(8===e.nodeType){var n=e.data;if("/$"===n){if(0===t){_l=Br(e.nextSibling);break e}t--}else"$"!==n&&"$!"!==n&&"$?"!==n||t++}e=e.nextSibling}_l=null}}else _l=Al?Br(e.stateNode.nextSibling):null;return!0}function Vl(){_l=Al=null,Pl=!1}var Bl=[];function Wl(){for(var e=0;e<Bl.length;e++)Bl[e]._workInProgressVersionPrimary=null;Bl.length=0}var Hl=E.ReactCurrentDispatcher,Kl=E.ReactCurrentBatchConfig,Gl=0,$l=null,ql=null,Zl=null,Xl=!1,Jl=!1;function eo(){throw Error(o(321))}function to(e,t){if(null===t)return!1;for(var n=0;n<t.length&&n<e.length;n++)if(!or(e[n],t[n]))return!1;return!0}function no(e,t,n,r,a,l){if(Gl=l,$l=t,t.memoizedState=null,t.updateQueue=null,t.lanes=0,Hl.current=null===e||null===e.memoizedState?To:Co,e=n(r,a),Jl){l=0;do{if(Jl=!1,!(25>l))throw Error(o(301));l+=1,Zl=ql=null,t.updateQueue=null,Hl.current=Io,e=n(r,a)}while(Jl)}if(Hl.current=jo,t=null!==ql&&null!==ql.next,Gl=0,Zl=ql=$l=null,Xl=!1,t)throw Error(o(300));return e}function ro(){var e={memoizedState:null,baseState:null,baseQueue:null,queue:null,next:null};return null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e,Zl}function ao(){if(null===ql){var e=$l.alternate;e=null!==e?e.memoizedState:null}else e=ql.next;var t=null===Zl?$l.memoizedState:Zl.next;if(null!==t)Zl=t,ql=e;else{if(null===e)throw Error(o(310));e={memoizedState:(ql=e).memoizedState,baseState:ql.baseState,baseQueue:ql.baseQueue,queue:ql.queue,next:null},null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e}return Zl}function lo(e,t){return"function"==typeof t?t(e):t}function oo(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=ql,a=r.baseQueue,l=n.pending;if(null!==l){if(null!==a){var i=a.next;a.next=l.next,l.next=i}r.baseQueue=a=l,n.pending=null}if(null!==a){a=a.next,r=r.baseState;var u=i=l=null,s=a;do{var c=s.lane;if((Gl&c)===c)null!==u&&(u=u.next={lane:0,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null}),r=s.eagerReducer===e?s.eagerState:e(r,s.action);else{var f={lane:c,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null};null===u?(i=u=f,l=r):u=u.next=f,$l.lanes|=c,Ai|=c}s=s.next}while(null!==s&&s!==a);null===u?l=r:u.next=i,or(r,t.memoizedState)||(Oo=!0),t.memoizedState=r,t.baseState=l,t.baseQueue=u,n.lastRenderedState=r}return[t.memoizedState,n.dispatch]}function io(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=n.dispatch,a=n.pending,l=t.memoizedState;if(null!==a){n.pending=null;var i=a=a.next;do{l=e(l,i.action),i=i.next}while(i!==a);or(l,t.memoizedState)||(Oo=!0),t.memoizedState=l,null===t.baseQueue&&(t.baseState=l),n.lastRenderedState=l}return[l,r]}function uo(e,t,n){var r=t._getVersion;r=r(t._source);var a=t._workInProgressVersionPrimary;if(null!==a?e=a===r:(e=e.mutableReadLanes,(e=(Gl&e)===e)&&(t._workInProgressVersionPrimary=r,Bl.push(t))),e)return n(t._source);throw Bl.push(t),Error(o(350))}function so(e,t,n,r){var a=ki;if(null===a)throw Error(o(349));var l=t._getVersion,i=l(t._source),u=Hl.current,s=u.useState((function(){return uo(a,t,n)})),c=s[1],f=s[0];s=Zl;var d=e.memoizedState,p=d.refs,y=p.getSnapshot,h=d.source;d=d.subscribe;var g=$l;return e.memoizedState={refs:p,source:t,subscribe:r},u.useEffect((function(){p.getSnapshot=n,p.setSnapshot=c;var e=l(t._source);if(!or(i,e)){e=n(t._source),or(f,e)||(c(e),e=iu(g),a.mutableReadLanes|=e&a.pendingLanes),e=a.mutableReadLanes,a.entangledLanes|=e;for(var r=a.entanglements,o=e;0<o;){var u=31-Vt(o),s=1<<u;r[u]|=e,o&=~s}}}),[n,t,r]),u.useEffect((function(){return r(t._source,(function(){var e=p.getSnapshot,n=p.setSnapshot;try{n(e(t._source));var r=iu(g);a.mutableReadLanes|=r&a.pendingLanes}catch(e){n((function(){throw e}))}}))}),[t,r]),or(y,n)&&or(h,t)&&or(d,r)||((e={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:f}).dispatch=c=ko.bind(null,$l,e),s.queue=e,s.baseQueue=null,f=uo(a,t,n),s.memoizedState=s.baseState=f),f}function co(e,t,n){return so(ao(),e,t,n)}function fo(e){var t=ro();return"function"==typeof e&&(e=e()),t.memoizedState=t.baseState=e,e=(e=t.queue={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:e}).dispatch=ko.bind(null,$l,e),[t.memoizedState,e]}function po(e,t,n,r){return e={tag:e,create:t,destroy:n,deps:r,next:null},null===(t=$l.updateQueue)?(t={lastEffect:null},$l.updateQueue=t,t.lastEffect=e.next=e):null===(n=t.lastEffect)?t.lastEffect=e.next=e:(r=n.next,n.next=e,e.next=r,t.lastEffect=e),e}function yo(e){return e={current:e},ro().memoizedState=e}function ho(){return ao().memoizedState}function go(e,t,n,r){var a=ro();$l.flags|=e,a.memoizedState=po(1|t,n,void 0,void 0===r?null:r)}function mo(e,t,n,r){var a=ao();r=void 0===r?null:r;var l=void 0;if(null!==ql){var o=ql.memoizedState;if(l=o.destroy,null!==r&&to(r,o.deps))return void po(t,n,l,r)}$l.flags|=e,a.memoizedState=po(1|t,n,l,r)}function vo(e,t){return go(516,4,e,t)}function bo(e,t){return mo(516,4,e,t)}function Mo(e,t){return mo(4,2,e,t)}function Eo(e,t){return"function"==typeof t?(e=e(),t(e),function(){t(null)}):null!=t?(e=e(),t.current=e,function(){t.current=null}):void 0}function Lo(e,t,n){return n=null!=n?n.concat([e]):null,mo(4,2,Eo.bind(null,t,e),n)}function No(){}function wo(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(n.memoizedState=[e,t],e)}function So(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(e=e(),n.memoizedState=[e,t],e)}function xo(e,t){var n=Qa();Fa(98>n?98:n,(function(){e(!0)})),Fa(97<n?97:n,(function(){var n=Kl.transition;Kl.transition=1;try{e(!1),t()}finally{Kl.transition=n}}))}function ko(e,t,n){var r=ou(),a=iu(e),l={lane:a,action:n,eagerReducer:null,eagerState:null,next:null},o=t.pending;if(null===o?l.next=l:(l.next=o.next,o.next=l),t.pending=l,o=e.alternate,e===$l||null!==o&&o===$l)Jl=Xl=!0;else{if(0===e.lanes&&(null===o||0===o.lanes)&&null!==(o=t.lastRenderedReducer))try{var i=t.lastRenderedState,u=o(i,n);if(l.eagerReducer=o,l.eagerState=u,or(u,i))return}catch(e){}uu(e,a,r)}}var jo={readContext:nl,useCallback:eo,useContext:eo,useEffect:eo,useImperativeHandle:eo,useLayoutEffect:eo,useMemo:eo,useReducer:eo,useRef:eo,useState:eo,useDebugValue:eo,useDeferredValue:eo,useTransition:eo,useMutableSource:eo,useOpaqueIdentifier:eo,unstable_isNewReconciler:!1},To={readContext:nl,useCallback:function(e,t){return ro().memoizedState=[e,void 0===t?null:t],e},useContext:nl,useEffect:vo,useImperativeHandle:function(e,t,n){return n=null!=n?n.concat([e]):null,go(4,2,Eo.bind(null,t,e),n)},useLayoutEffect:function(e,t){return go(4,2,e,t)},useMemo:function(e,t){var n=ro();return t=void 0===t?null:t,e=e(),n.memoizedState=[e,t],e},useReducer:function(e,t,n){var r=ro();return t=void 0!==n?n(t):t,r.memoizedState=r.baseState=t,e=(e=r.queue={pending:null,dispatch:null,lastRenderedReducer:e,lastRenderedState:t}).dispatch=ko.bind(null,$l,e),[r.memoizedState,e]},useRef:yo,useState:fo,useDebugValue:No,useDeferredValue:function(e){var t=fo(e),n=t[0],r=t[1];return vo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=fo(!1),t=e[0];return yo(e=xo.bind(null,e[1])),[e,t]},useMutableSource:function(e,t,n){var r=ro();return r.memoizedState={refs:{getSnapshot:t,setSnapshot:null},source:e,subscribe:n},so(r,e,t,n)},useOpaqueIdentifier:function(){if(Pl){var e=!1,t=function(e){return{$$typeof:A,toString:e,valueOf:e}}((function(){throw e||(e=!0,n("r:"+(Hr++).toString(36))),Error(o(355))})),n=fo(t)[1];return 0==(2&$l.mode)&&($l.flags|=516,po(5,(function(){n("r:"+(Hr++).toString(36))}),void 0,null)),t}return fo(t="r:"+(Hr++).toString(36)),t},unstable_isNewReconciler:!1},Co={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:oo,useRef:ho,useState:function(){return oo(lo)},useDebugValue:No,useDeferredValue:function(e){var t=oo(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=oo(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return oo(lo)[0]},unstable_isNewReconciler:!1},Io={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:io,useRef:ho,useState:function(){return io(lo)},useDebugValue:No,useDeferredValue:function(e){var t=io(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=io(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return io(lo)[0]},unstable_isNewReconciler:!1},Do=E.ReactCurrentOwner,Oo=!1;function zo(e,t,n,r){t.child=null===e?Nl(t,null,n,r):Ll(t,e.child,n,r)}function Ao(e,t,n,r,a){n=n.render;var l=t.ref;return tl(t,a),r=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,r,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function _o(e,t,n,r,a,l){if(null===e){var o=n.type;return"function"!=typeof o||Yu(o)||void 0!==o.defaultProps||null!==n.compare||void 0!==n.defaultProps?((e=Ru(n.type,null,r,t,t.mode,l)).ref=t.ref,e.return=t,t.child=e):(t.tag=15,t.type=o,Po(e,t,o,r,a,l))}return o=e.child,0==(a&l)&&(a=o.memoizedProps,(n=null!==(n=n.compare)?n:ur)(a,r)&&e.ref===t.ref)?Jo(e,t,l):(t.flags|=1,(e=Qu(o,r)).ref=t.ref,e.return=t,t.child=e)}function Po(e,t,n,r,a,l){if(null!==e&&ur(e.memoizedProps,r)&&e.ref===t.ref){if(Oo=!1,0==(l&a))return t.lanes=e.lanes,Jo(e,t,l);0!=(16384&e.flags)&&(Oo=!0)}return Qo(e,t,n,r,l)}function Uo(e,t,n){var r=t.pendingProps,a=r.children,l=null!==e?e.memoizedState:null;if("hidden"===r.mode||"unstable-defer-without-hiding"===r.mode)if(0==(4&t.mode))t.memoizedState={baseLanes:0},gu(0,n);else{if(0==(1073741824&n))return e=null!==l?l.baseLanes|n:n,t.lanes=t.childLanes=1073741824,t.memoizedState={baseLanes:e},gu(0,e),null;t.memoizedState={baseLanes:0},gu(0,null!==l?l.baseLanes:n)}else null!==l?(r=l.baseLanes|n,t.memoizedState=null):r=n,gu(0,r);return zo(e,t,a,n),t.child}function Yo(e,t){var n=t.ref;(null===e&&null!==n||null!==e&&e.ref!==n)&&(t.flags|=128)}function Qo(e,t,n,r,a){var l=pa(n)?fa:sa.current;return l=da(t,l),tl(t,a),n=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,n,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function Ro(e,t,n,r,a){if(pa(n)){var l=!0;ma(t)}else l=!1;if(tl(t,a),null===t.stateNode)null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),hl(t,n,r),ml(t,n,r,a),r=!0;else if(null===e){var o=t.stateNode,i=t.memoizedProps;o.props=i;var u=o.context,s=n.contextType;s="object"==typeof s&&null!==s?nl(s):da(t,s=pa(n)?fa:sa.current);var c=n.getDerivedStateFromProps,f="function"==typeof c||"function"==typeof o.getSnapshotBeforeUpdate;f||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==r||u!==s)&&gl(t,o,r,s),rl=!1;var d=t.memoizedState;o.state=d,sl(t,r,o,a),u=t.memoizedState,i!==r||d!==u||ca.current||rl?("function"==typeof c&&(dl(t,n,c,r),u=t.memoizedState),(i=rl||yl(t,n,i,r,d,u,s))?(f||"function"!=typeof o.UNSAFE_componentWillMount&&"function"!=typeof o.componentWillMount||("function"==typeof o.componentWillMount&&o.componentWillMount(),"function"==typeof o.UNSAFE_componentWillMount&&o.UNSAFE_componentWillMount()),"function"==typeof o.componentDidMount&&(t.flags|=4)):("function"==typeof o.componentDidMount&&(t.flags|=4),t.memoizedProps=r,t.memoizedState=u),o.props=r,o.state=u,o.context=s,r=i):("function"==typeof o.componentDidMount&&(t.flags|=4),r=!1)}else{o=t.stateNode,ll(e,t),i=t.memoizedProps,s=t.type===t.elementType?i:Ka(t.type,i),o.props=s,f=t.pendingProps,d=o.context,u="object"==typeof(u=n.contextType)&&null!==u?nl(u):da(t,u=pa(n)?fa:sa.current);var p=n.getDerivedStateFromProps;(c="function"==typeof p||"function"==typeof o.getSnapshotBeforeUpdate)||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==f||d!==u)&&gl(t,o,r,u),rl=!1,d=t.memoizedState,o.state=d,sl(t,r,o,a);var y=t.memoizedState;i!==f||d!==y||ca.current||rl?("function"==typeof p&&(dl(t,n,p,r),y=t.memoizedState),(s=rl||yl(t,n,s,r,d,y,u))?(c||"function"!=typeof o.UNSAFE_componentWillUpdate&&"function"!=typeof o.componentWillUpdate||("function"==typeof o.componentWillUpdate&&o.componentWillUpdate(r,y,u),"function"==typeof o.UNSAFE_componentWillUpdate&&o.UNSAFE_componentWillUpdate(r,y,u)),"function"==typeof o.componentDidUpdate&&(t.flags|=4),"function"==typeof o.getSnapshotBeforeUpdate&&(t.flags|=256)):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),t.memoizedProps=r,t.memoizedState=y),o.props=r,o.state=y,o.context=u,r=s):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),r=!1)}return Fo(e,t,n,r,l,a)}function Fo(e,t,n,r,a,l){Yo(e,t);var o=0!=(64&t.flags);if(!r&&!o)return a&&va(t,n,!1),Jo(e,t,l);r=t.stateNode,Do.current=t;var i=o&&"function"!=typeof n.getDerivedStateFromError?null:r.render();return t.flags|=1,null!==e&&o?(t.child=Ll(t,e.child,null,l),t.child=Ll(t,null,i,l)):zo(e,t,i,l),t.memoizedState=r.state,a&&va(t,n,!0),t.child}function Vo(e){var t=e.stateNode;t.pendingContext?ha(0,t.pendingContext,t.pendingContext!==t.context):t.context&&ha(0,t.context,!1),Tl(e,t.containerInfo)}var Bo,Wo,Ho,Ko={dehydrated:null,retryLane:0};function Go(e,t,n){var r,a=t.pendingProps,l=Ol.current,o=!1;return(r=0!=(64&t.flags))||(r=(null===e||null!==e.memoizedState)&&0!=(2&l)),r?(o=!0,t.flags&=-65):null!==e&&null===e.memoizedState||void 0===a.fallback||!0===a.unstable_avoidThisFallback||(l|=1),ia(Ol,1&l),null===e?(void 0!==a.fallback&&Ql(t),e=a.children,l=a.fallback,o?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,e):"number"==typeof a.unstable_expectedLoadTime?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,t.lanes=33554432,e):((n=Vu({mode:"visible",children:e},t.mode,n,null)).return=t,t.child=n)):(e.memoizedState,o?(a=function(e,t,n,r,a){var l=t.mode,o=e.child;e=o.sibling;var i={mode:"hidden",children:n};return 0==(2&l)&&t.child!==o?((n=t.child).childLanes=0,n.pendingProps=i,null!==(o=n.lastEffect)?(t.firstEffect=n.firstEffect,t.lastEffect=o,o.nextEffect=null):t.firstEffect=t.lastEffect=null):n=Qu(o,i),null!==e?r=Qu(e,r):(r=Fu(r,l,a,null)).flags|=2,r.return=t,n.return=t,n.sibling=r,t.child=n,r}(e,t,a.children,a.fallback,n),o=t.child,l=e.child.memoizedState,o.memoizedState=null===l?{baseLanes:n}:{baseLanes:l.baseLanes|n},o.childLanes=e.childLanes&~n,t.memoizedState=Ko,a):(n=function(e,t,n,r){var a=e.child;return e=a.sibling,n=Qu(a,{mode:"visible",children:n}),0==(2&t.mode)&&(n.lanes=r),n.return=t,n.sibling=null,null!==e&&(e.nextEffect=null,e.flags=8,t.firstEffect=t.lastEffect=e),t.child=n}(e,t,a.children,n),t.memoizedState=null,n))}function $o(e,t,n,r){var a=e.mode,l=e.child;return t={mode:"hidden",children:t},0==(2&a)&&null!==l?(l.childLanes=0,l.pendingProps=t):l=Vu(t,a,0,null),n=Fu(n,a,r,null),l.return=e,n.return=e,l.sibling=n,e.child=l,n}function qo(e,t){e.lanes|=t;var n=e.alternate;null!==n&&(n.lanes|=t),el(e.return,t)}function Zo(e,t,n,r,a,l){var o=e.memoizedState;null===o?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:r,tail:n,tailMode:a,lastEffect:l}:(o.isBackwards=t,o.rendering=null,o.renderingStartTime=0,o.last=r,o.tail=n,o.tailMode=a,o.lastEffect=l)}function Xo(e,t,n){var r=t.pendingProps,a=r.revealOrder,l=r.tail;if(zo(e,t,r.children,n),0!=(2&(r=Ol.current)))r=1&r|2,t.flags|=64;else{if(null!==e&&0!=(64&e.flags))e:for(e=t.child;null!==e;){if(13===e.tag)null!==e.memoizedState&&qo(e,n);else if(19===e.tag)qo(e,n);else if(null!==e.child){e.child.return=e,e=e.child;continue}if(e===t)break e;for(;null===e.sibling;){if(null===e.return||e.return===t)break e;e=e.return}e.sibling.return=e.return,e=e.sibling}r&=1}if(ia(Ol,r),0==(2&t.mode))t.memoizedState=null;else switch(a){case"forwards":for(n=t.child,a=null;null!==n;)null!==(e=n.alternate)&&null===zl(e)&&(a=n),n=n.sibling;null===(n=a)?(a=t.child,t.child=null):(a=n.sibling,n.sibling=null),Zo(t,!1,a,n,l,t.lastEffect);break;case"backwards":for(n=null,a=t.child,t.child=null;null!==a;){if(null!==(e=a.alternate)&&null===zl(e)){t.child=a;break}e=a.sibling,a.sibling=n,n=a,a=e}Zo(t,!0,n,null,l,t.lastEffect);break;case"together":Zo(t,!1,null,null,void 0,t.lastEffect);break;default:t.memoizedState=null}return t.child}function Jo(e,t,n){if(null!==e&&(t.dependencies=e.dependencies),Ai|=t.lanes,0!=(n&t.childLanes)){if(null!==e&&t.child!==e.child)throw Error(o(153));if(null!==t.child){for(n=Qu(e=t.child,e.pendingProps),t.child=n,n.return=t;null!==e.sibling;)e=e.sibling,(n=n.sibling=Qu(e,e.pendingProps)).return=t;n.sibling=null}return t.child}return null}function ei(e,t){if(!Pl)switch(e.tailMode){case"hidden":t=e.tail;for(var n=null;null!==t;)null!==t.alternate&&(n=t),t=t.sibling;null===n?e.tail=null:n.sibling=null;break;case"collapsed":n=e.tail;for(var r=null;null!==n;)null!==n.alternate&&(r=n),n=n.sibling;null===r?t||null===e.tail?e.tail=null:e.tail.sibling=null:r.sibling=null}}function ti(e,t,n){var r=t.pendingProps;switch(t.tag){case 2:case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return null;case 1:return pa(t.type)&&ya(),null;case 3:return Cl(),oa(ca),oa(sa),Wl(),(r=t.stateNode).pendingContext&&(r.context=r.pendingContext,r.pendingContext=null),null!==e&&null!==e.child||(Fl(t)?t.flags|=4:r.hydrate||(t.flags|=256)),null;case 5:Dl(t);var l=jl(kl.current);if(n=t.type,null!==e&&null!=t.stateNode)Wo(e,t,n,r),e.ref!==t.ref&&(t.flags|=128);else{if(!r){if(null===t.stateNode)throw Error(o(166));return null}if(e=jl(Sl.current),Fl(t)){r=t.stateNode,n=t.type;var i=t.memoizedProps;switch(r[Gr]=t,r[$r]=i,n){case"dialog":xr("cancel",r),xr("close",r);break;case"iframe":case"object":case"embed":xr("load",r);break;case"video":case"audio":for(e=0;e<Lr.length;e++)xr(Lr[e],r);break;case"source":xr("error",r);break;case"img":case"image":case"link":xr("error",r),xr("load",r);break;case"details":xr("toggle",r);break;case"input":ee(r,i),xr("invalid",r);break;case"select":r._wrapperState={wasMultiple:!!i.multiple},xr("invalid",r);break;case"textarea":ue(r,i),xr("invalid",r)}for(var s in Ne(n,i),e=null,i)i.hasOwnProperty(s)&&(l=i[s],"children"===s?"string"==typeof l?r.textContent!==l&&(e=["children",l]):"number"==typeof l&&r.textContent!==""+l&&(e=["children",""+l]):u.hasOwnProperty(s)&&null!=l&&"onScroll"===s&&xr("scroll",r));switch(n){case"input":q(r),re(r,i,!0);break;case"textarea":q(r),ce(r);break;case"select":case"option":break;default:"function"==typeof i.onClick&&(r.onclick=_r)}r=e,t.updateQueue=r,null!==r&&(t.flags|=4)}else{switch(s=9===l.nodeType?l:l.ownerDocument,e===fe&&(e=de(n)),e===fe?"script"===n?((e=s.createElement("div")).innerHTML="<script><\/script>",e=e.removeChild(e.firstChild)):"string"==typeof r.is?e=s.createElement(n,{is:r.is}):(e=s.createElement(n),"select"===n&&(s=e,r.multiple?s.multiple=!0:r.size&&(s.size=r.size))):e=s.createElementNS(e,n),e[Gr]=t,e[$r]=r,Bo(e,t),t.stateNode=e,s=we(n,r),n){case"dialog":xr("cancel",e),xr("close",e),l=r;break;case"iframe":case"object":case"embed":xr("load",e),l=r;break;case"video":case"audio":for(l=0;l<Lr.length;l++)xr(Lr[l],e);l=r;break;case"source":xr("error",e),l=r;break;case"img":case"image":case"link":xr("error",e),xr("load",e),l=r;break;case"details":xr("toggle",e),l=r;break;case"input":ee(e,r),l=J(e,r),xr("invalid",e);break;case"option":l=le(e,r);break;case"select":e._wrapperState={wasMultiple:!!r.multiple},l=a({},r,{value:void 0}),xr("invalid",e);break;case"textarea":ue(e,r),l=ie(e,r),xr("invalid",e);break;default:l=r}Ne(n,l);var c=l;for(i in c)if(c.hasOwnProperty(i)){var f=c[i];"style"===i?Ee(e,f):"dangerouslySetInnerHTML"===i?null!=(f=f?f.__html:void 0)&&ge(e,f):"children"===i?"string"==typeof f?("textarea"!==n||""!==f)&&me(e,f):"number"==typeof f&&me(e,""+f):"suppressContentEditableWarning"!==i&&"suppressHydrationWarning"!==i&&"autoFocus"!==i&&(u.hasOwnProperty(i)?null!=f&&"onScroll"===i&&xr("scroll",e):null!=f&&M(e,i,f,s))}switch(n){case"input":q(e),re(e,r,!1);break;case"textarea":q(e),ce(e);break;case"option":null!=r.value&&e.setAttribute("value",""+G(r.value));break;case"select":e.multiple=!!r.multiple,null!=(i=r.value)?oe(e,!!r.multiple,i,!1):null!=r.defaultValue&&oe(e,!!r.multiple,r.defaultValue,!0);break;default:"function"==typeof l.onClick&&(e.onclick=_r)}Yr(n,r)&&(t.flags|=4)}null!==t.ref&&(t.flags|=128)}return null;case 6:if(e&&null!=t.stateNode)Ho(0,t,e.memoizedProps,r);else{if("string"!=typeof r&&null===t.stateNode)throw Error(o(166));n=jl(kl.current),jl(Sl.current),Fl(t)?(r=t.stateNode,n=t.memoizedProps,r[Gr]=t,r.nodeValue!==n&&(t.flags|=4)):((r=(9===n.nodeType?n:n.ownerDocument).createTextNode(r))[Gr]=t,t.stateNode=r)}return null;case 13:return oa(Ol),r=t.memoizedState,0!=(64&t.flags)?(t.lanes=n,t):(r=null!==r,n=!1,null===e?void 0!==t.memoizedProps.fallback&&Fl(t):n=null!==e.memoizedState,r&&!n&&0!=(2&t.mode)&&(null===e&&!0!==t.memoizedProps.unstable_avoidThisFallback||0!=(1&Ol.current)?0===Di&&(Di=3):(0!==Di&&3!==Di||(Di=4),null===ki||0==(134217727&Ai)&&0==(134217727&_i)||du(ki,Ti))),(r||n)&&(t.flags|=4),null);case 4:return Cl(),null===e&&jr(t.stateNode.containerInfo),null;case 10:return Ja(t),null;case 17:return pa(t.type)&&ya(),null;case 19:if(oa(Ol),null===(r=t.memoizedState))return null;if(i=0!=(64&t.flags),null===(s=r.rendering))if(i)ei(r,!1);else{if(0!==Di||null!==e&&0!=(64&e.flags))for(e=t.child;null!==e;){if(null!==(s=zl(e))){for(t.flags|=64,ei(r,!1),null!==(i=s.updateQueue)&&(t.updateQueue=i,t.flags|=4),null===r.lastEffect&&(t.firstEffect=null),t.lastEffect=r.lastEffect,r=n,n=t.child;null!==n;)e=r,(i=n).flags&=2,i.nextEffect=null,i.firstEffect=null,i.lastEffect=null,null===(s=i.alternate)?(i.childLanes=0,i.lanes=e,i.child=null,i.memoizedProps=null,i.memoizedState=null,i.updateQueue=null,i.dependencies=null,i.stateNode=null):(i.childLanes=s.childLanes,i.lanes=s.lanes,i.child=s.child,i.memoizedProps=s.memoizedProps,i.memoizedState=s.memoizedState,i.updateQueue=s.updateQueue,i.type=s.type,e=s.dependencies,i.dependencies=null===e?null:{lanes:e.lanes,firstContext:e.firstContext}),n=n.sibling;return ia(Ol,1&Ol.current|2),t.child}e=e.sibling}null!==r.tail&&Ya()>Qi&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432)}else{if(!i)if(null!==(e=zl(s))){if(t.flags|=64,i=!0,null!==(n=e.updateQueue)&&(t.updateQueue=n,t.flags|=4),ei(r,!0),null===r.tail&&"hidden"===r.tailMode&&!s.alternate&&!Pl)return null!==(t=t.lastEffect=r.lastEffect)&&(t.nextEffect=null),null}else 2*Ya()-r.renderingStartTime>Qi&&1073741824!==n&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432);r.isBackwards?(s.sibling=t.child,t.child=s):(null!==(n=r.last)?n.sibling=s:t.child=s,r.last=s)}return null!==r.tail?(n=r.tail,r.rendering=n,r.tail=n.sibling,r.lastEffect=t.lastEffect,r.renderingStartTime=Ya(),n.sibling=null,t=Ol.current,ia(Ol,i?1&t|2:1&t),n):null;case 23:case 24:return mu(),null!==e&&null!==e.memoizedState!=(null!==t.memoizedState)&&"unstable-defer-without-hiding"!==r.mode&&(t.flags|=4),null}throw Error(o(156,t.tag))}function ni(e){switch(e.tag){case 1:pa(e.type)&&ya();var t=e.flags;return 4096&t?(e.flags=-4097&t|64,e):null;case 3:if(Cl(),oa(ca),oa(sa),Wl(),0!=(64&(t=e.flags)))throw Error(o(285));return e.flags=-4097&t|64,e;case 5:return Dl(e),null;case 13:return oa(Ol),4096&(t=e.flags)?(e.flags=-4097&t|64,e):null;case 19:return oa(Ol),null;case 4:return Cl(),null;case 10:return Ja(e),null;case 23:case 24:return mu(),null;default:return null}}function ri(e,t){try{var n="",r=t;do{n+=H(r),r=r.return}while(r);var a=n}catch(e){a="\nError generating stack: "+e.message+"\n"+e.stack}return{value:e,source:t,stack:a}}function ai(e,t){try{console.error(t.value)}catch(e){setTimeout((function(){throw e}))}}Bo=function(e,t){for(var n=t.child;null!==n;){if(5===n.tag||6===n.tag)e.appendChild(n.stateNode);else if(4!==n.tag&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===t)break;for(;null===n.sibling;){if(null===n.return||n.return===t)return;n=n.return}n.sibling.return=n.return,n=n.sibling}},Wo=function(e,t,n,r){var l=e.memoizedProps;if(l!==r){e=t.stateNode,jl(Sl.current);var o,i=null;switch(n){case"input":l=J(e,l),r=J(e,r),i=[];break;case"option":l=le(e,l),r=le(e,r),i=[];break;case"select":l=a({},l,{value:void 0}),r=a({},r,{value:void 0}),i=[];break;case"textarea":l=ie(e,l),r=ie(e,r),i=[];break;default:"function"!=typeof l.onClick&&"function"==typeof r.onClick&&(e.onclick=_r)}for(f in Ne(n,r),n=null,l)if(!r.hasOwnProperty(f)&&l.hasOwnProperty(f)&&null!=l[f])if("style"===f){var s=l[f];for(o in s)s.hasOwnProperty(o)&&(n||(n={}),n[o]="")}else"dangerouslySetInnerHTML"!==f&&"children"!==f&&"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&"autoFocus"!==f&&(u.hasOwnProperty(f)?i||(i=[]):(i=i||[]).push(f,null));for(f in r){var c=r[f];if(s=null!=l?l[f]:void 0,r.hasOwnProperty(f)&&c!==s&&(null!=c||null!=s))if("style"===f)if(s){for(o in s)!s.hasOwnProperty(o)||c&&c.hasOwnProperty(o)||(n||(n={}),n[o]="");for(o in c)c.hasOwnProperty(o)&&s[o]!==c[o]&&(n||(n={}),n[o]=c[o])}else n||(i||(i=[]),i.push(f,n)),n=c;else"dangerouslySetInnerHTML"===f?(c=c?c.__html:void 0,s=s?s.__html:void 0,null!=c&&s!==c&&(i=i||[]).push(f,c)):"children"===f?"string"!=typeof c&&"number"!=typeof c||(i=i||[]).push(f,""+c):"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&(u.hasOwnProperty(f)?(null!=c&&"onScroll"===f&&xr("scroll",e),i||s===c||(i=[])):"object"==typeof c&&null!==c&&c.$$typeof===A?c.toString():(i=i||[]).push(f,c))}n&&(i=i||[]).push("style",n);var f=i;(t.updateQueue=f)&&(t.flags|=4)}},Ho=function(e,t,n,r){n!==r&&(t.flags|=4)};var li="function"==typeof WeakMap?WeakMap:Map;function oi(e,t,n){(n=ol(-1,n)).tag=3,n.payload={element:null};var r=t.value;return n.callback=function(){Bi||(Bi=!0,Wi=r),ai(0,t)},n}function ii(e,t,n){(n=ol(-1,n)).tag=3;var r=e.type.getDerivedStateFromError;if("function"==typeof r){var a=t.value;n.payload=function(){return ai(0,t),r(a)}}var l=e.stateNode;return null!==l&&"function"==typeof l.componentDidCatch&&(n.callback=function(){"function"!=typeof r&&(null===Hi?Hi=new Set([this]):Hi.add(this),ai(0,t));var e=t.stack;this.componentDidCatch(t.value,{componentStack:null!==e?e:""})}),n}var ui="function"==typeof WeakSet?WeakSet:Set;function si(e){var t=e.ref;if(null!==t)if("function"==typeof t)try{t(null)}catch(t){zu(e,t)}else t.current=null}function ci(e,t){switch(t.tag){case 0:case 11:case 15:case 22:return;case 1:if(256&t.flags&&null!==e){var n=e.memoizedProps,r=e.memoizedState;t=(e=t.stateNode).getSnapshotBeforeUpdate(t.elementType===t.type?n:Ka(t.type,n),r),e.__reactInternalSnapshotBeforeUpdate=t}return;case 3:return void(256&t.flags&&Vr(t.stateNode.containerInfo));case 5:case 6:case 4:case 17:return}throw Error(o(163))}function fi(e,t,n){switch(n.tag){case 0:case 11:case 15:case 22:if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{if(3==(3&e.tag)){var r=e.create;e.destroy=r()}e=e.next}while(e!==t)}if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{var a=e;r=a.next,0!=(4&(a=a.tag))&&0!=(1&a)&&(Iu(n,e),Cu(n,e)),e=r}while(e!==t)}return;case 1:return e=n.stateNode,4&n.flags&&(null===t?e.componentDidMount():(r=n.elementType===n.type?t.memoizedProps:Ka(n.type,t.memoizedProps),e.componentDidUpdate(r,t.memoizedState,e.__reactInternalSnapshotBeforeUpdate))),void(null!==(t=n.updateQueue)&&cl(n,t,e));case 3:if(null!==(t=n.updateQueue)){if(e=null,null!==n.child)switch(n.child.tag){case 5:e=n.child.stateNode;break;case 1:e=n.child.stateNode}cl(n,t,e)}return;case 5:return e=n.stateNode,void(null===t&&4&n.flags&&Yr(n.type,n.memoizedProps)&&e.focus());case 6:case 4:case 12:return;case 13:return void(null===n.memoizedState&&(n=n.alternate,null!==n&&(n=n.memoizedState,null!==n&&(n=n.dehydrated,null!==n&&Et(n)))));case 19:case 17:case 20:case 21:case 23:case 24:return}throw Error(o(163))}function di(e,t){for(var n=e;;){if(5===n.tag){var r=n.stateNode;if(t)"function"==typeof(r=r.style).setProperty?r.setProperty("display","none","important"):r.display="none";else{r=n.stateNode;var a=n.memoizedProps.style;a=null!=a&&a.hasOwnProperty("display")?a.display:null,r.style.display=Me("display",a)}}else if(6===n.tag)n.stateNode.nodeValue=t?"":n.memoizedProps;else if((23!==n.tag&&24!==n.tag||null===n.memoizedState||n===e)&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===e)break;for(;null===n.sibling;){if(null===n.return||n.return===e)return;n=n.return}n.sibling.return=n.return,n=n.sibling}}function pi(e,t){if(Ma&&"function"==typeof Ma.onCommitFiberUnmount)try{Ma.onCommitFiberUnmount(ba,t)}catch(e){}switch(t.tag){case 0:case 11:case 14:case 15:case 22:if(null!==(e=t.updateQueue)&&null!==(e=e.lastEffect)){var n=e=e.next;do{var r=n,a=r.destroy;if(r=r.tag,void 0!==a)if(0!=(4&r))Iu(t,n);else{r=t;try{a()}catch(e){zu(r,e)}}n=n.next}while(n!==e)}break;case 1:if(si(t),"function"==typeof(e=t.stateNode).componentWillUnmount)try{e.props=t.memoizedProps,e.state=t.memoizedState,e.componentWillUnmount()}catch(e){zu(t,e)}break;case 5:si(t);break;case 4:bi(e,t)}}function yi(e){e.alternate=null,e.child=null,e.dependencies=null,e.firstEffect=null,e.lastEffect=null,e.memoizedProps=null,e.memoizedState=null,e.pendingProps=null,e.return=null,e.updateQueue=null}function hi(e){return 5===e.tag||3===e.tag||4===e.tag}function gi(e){e:{for(var t=e.return;null!==t;){if(hi(t))break e;t=t.return}throw Error(o(160))}var n=t;switch(t=n.stateNode,n.tag){case 5:var r=!1;break;case 3:case 4:t=t.containerInfo,r=!0;break;default:throw Error(o(161))}16&n.flags&&(me(t,""),n.flags&=-17);e:t:for(n=e;;){for(;null===n.sibling;){if(null===n.return||hi(n.return)){n=null;break e}n=n.return}for(n.sibling.return=n.return,n=n.sibling;5!==n.tag&&6!==n.tag&&18!==n.tag;){if(2&n.flags)continue t;if(null===n.child||4===n.tag)continue t;n.child.return=n,n=n.child}if(!(2&n.flags)){n=n.stateNode;break e}}r?mi(e,n,t):vi(e,n,t)}function mi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?8===n.nodeType?n.parentNode.insertBefore(e,t):n.insertBefore(e,t):(8===n.nodeType?(t=n.parentNode).insertBefore(e,n):(t=n).appendChild(e),null!=(n=n._reactRootContainer)||null!==t.onclick||(t.onclick=_r));else if(4!==r&&null!==(e=e.child))for(mi(e,t,n),e=e.sibling;null!==e;)mi(e,t,n),e=e.sibling}function vi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?n.insertBefore(e,t):n.appendChild(e);else if(4!==r&&null!==(e=e.child))for(vi(e,t,n),e=e.sibling;null!==e;)vi(e,t,n),e=e.sibling}function bi(e,t){for(var n,r,a=t,l=!1;;){if(!l){l=a.return;e:for(;;){if(null===l)throw Error(o(160));switch(n=l.stateNode,l.tag){case 5:r=!1;break e;case 3:case 4:n=n.containerInfo,r=!0;break e}l=l.return}l=!0}if(5===a.tag||6===a.tag){e:for(var i=e,u=a,s=u;;)if(pi(i,s),null!==s.child&&4!==s.tag)s.child.return=s,s=s.child;else{if(s===u)break e;for(;null===s.sibling;){if(null===s.return||s.return===u)break e;s=s.return}s.sibling.return=s.return,s=s.sibling}r?(i=n,u=a.stateNode,8===i.nodeType?i.parentNode.removeChild(u):i.removeChild(u)):n.removeChild(a.stateNode)}else if(4===a.tag){if(null!==a.child){n=a.stateNode.containerInfo,r=!0,a.child.return=a,a=a.child;continue}}else if(pi(e,a),null!==a.child){a.child.return=a,a=a.child;continue}if(a===t)break;for(;null===a.sibling;){if(null===a.return||a.return===t)return;4===(a=a.return).tag&&(l=!1)}a.sibling.return=a.return,a=a.sibling}}function Mi(e,t){switch(t.tag){case 0:case 11:case 14:case 15:case 22:var n=t.updateQueue;if(null!==(n=null!==n?n.lastEffect:null)){var r=n=n.next;do{3==(3&r.tag)&&(e=r.destroy,r.destroy=void 0,void 0!==e&&e()),r=r.next}while(r!==n)}return;case 1:return;case 5:if(null!=(n=t.stateNode)){r=t.memoizedProps;var a=null!==e?e.memoizedProps:r;e=t.type;var l=t.updateQueue;if(t.updateQueue=null,null!==l){for(n[$r]=r,"input"===e&&"radio"===r.type&&null!=r.name&&te(n,r),we(e,a),t=we(e,r),a=0;a<l.length;a+=2){var i=l[a],u=l[a+1];"style"===i?Ee(n,u):"dangerouslySetInnerHTML"===i?ge(n,u):"children"===i?me(n,u):M(n,i,u,t)}switch(e){case"input":ne(n,r);break;case"textarea":se(n,r);break;case"select":e=n._wrapperState.wasMultiple,n._wrapperState.wasMultiple=!!r.multiple,null!=(l=r.value)?oe(n,!!r.multiple,l,!1):e!==!!r.multiple&&(null!=r.defaultValue?oe(n,!!r.multiple,r.defaultValue,!0):oe(n,!!r.multiple,r.multiple?[]:"",!1))}}}return;case 6:if(null===t.stateNode)throw Error(o(162));return void(t.stateNode.nodeValue=t.memoizedProps);case 3:return void((n=t.stateNode).hydrate&&(n.hydrate=!1,Et(n.containerInfo)));case 12:return;case 13:return null!==t.memoizedState&&(Yi=Ya(),di(t.child,!0)),void Ei(t);case 19:return void Ei(t);case 17:return;case 23:case 24:return void di(t,null!==t.memoizedState)}throw Error(o(163))}function Ei(e){var t=e.updateQueue;if(null!==t){e.updateQueue=null;var n=e.stateNode;null===n&&(n=e.stateNode=new ui),t.forEach((function(t){var r=_u.bind(null,e,t);n.has(t)||(n.add(t),t.then(r,r))}))}}function Li(e,t){return null!==e&&(null===(e=e.memoizedState)||null!==e.dehydrated)&&null!==(t=t.memoizedState)&&null===t.dehydrated}var Ni=Math.ceil,wi=E.ReactCurrentDispatcher,Si=E.ReactCurrentOwner,xi=0,ki=null,ji=null,Ti=0,Ci=0,Ii=la(0),Di=0,Oi=null,zi=0,Ai=0,_i=0,Pi=0,Ui=null,Yi=0,Qi=1/0;function Ri(){Qi=Ya()+500}var Fi,Vi=null,Bi=!1,Wi=null,Hi=null,Ki=!1,Gi=null,$i=90,qi=[],Zi=[],Xi=null,Ji=0,eu=null,tu=-1,nu=0,ru=0,au=null,lu=!1;function ou(){return 0!=(48&xi)?Ya():-1!==tu?tu:tu=Ya()}function iu(e){if(0==(2&(e=e.mode)))return 1;if(0==(4&e))return 99===Qa()?1:2;if(0===nu&&(nu=zi),0!==Ha.transition){0!==ru&&(ru=null!==Ui?Ui.pendingLanes:0),e=nu;var t=4186112&~ru;return 0==(t&=-t)&&0==(t=(e=4186112&~e)&-e)&&(t=8192),t}return e=Qa(),e=Yt(0!=(4&xi)&&98===e?12:e=function(e){switch(e){case 99:return 15;case 98:return 10;case 97:case 96:return 8;case 95:return 2;default:return 0}}(e),nu)}function uu(e,t,n){if(50<Ji)throw Ji=0,eu=null,Error(o(185));if(null===(e=su(e,t)))return null;Ft(e,t,n),e===ki&&(_i|=t,4===Di&&du(e,Ti));var r=Qa();1===t?0!=(8&xi)&&0==(48&xi)?pu(e):(cu(e,n),0===xi&&(Ri(),Ba())):(0==(4&xi)||98!==r&&99!==r||(null===Xi?Xi=new Set([e]):Xi.add(e)),cu(e,n)),Ui=e}function su(e,t){e.lanes|=t;var n=e.alternate;for(null!==n&&(n.lanes|=t),n=e,e=e.return;null!==e;)e.childLanes|=t,null!==(n=e.alternate)&&(n.childLanes|=t),n=e,e=e.return;return 3===n.tag?n.stateNode:null}function cu(e,t){for(var n=e.callbackNode,r=e.suspendedLanes,a=e.pingedLanes,l=e.expirationTimes,i=e.pendingLanes;0<i;){var u=31-Vt(i),s=1<<u,c=l[u];if(-1===c){if(0==(s&r)||0!=(s&a)){c=t,_t(s);var f=At;l[u]=10<=f?c+250:6<=f?c+5e3:-1}}else c<=t&&(e.expiredLanes|=s);i&=~s}if(r=Pt(e,e===ki?Ti:0),t=At,0===r)null!==n&&(n!==Oa&&Na(n),e.callbackNode=null,e.callbackPriority=0);else{if(null!==n){if(e.callbackPriority===t)return;n!==Oa&&Na(n)}15===t?(n=pu.bind(null,e),null===Aa?(Aa=[n],_a=La(ja,Wa)):Aa.push(n),n=Oa):n=14===t?Va(99,pu.bind(null,e)):Va(n=function(e){switch(e){case 15:case 14:return 99;case 13:case 12:case 11:case 10:return 98;case 9:case 8:case 7:case 6:case 4:case 5:return 97;case 3:case 2:case 1:return 95;case 0:return 90;default:throw Error(o(358,e))}}(t),fu.bind(null,e)),e.callbackPriority=t,e.callbackNode=n}}function fu(e){if(tu=-1,ru=nu=0,0!=(48&xi))throw Error(o(327));var t=e.callbackNode;if(Tu()&&e.callbackNode!==t)return null;var n=Pt(e,e===ki?Ti:0);if(0===n)return null;var r=n,a=xi;xi|=16;var l=Mu();for(ki===e&&Ti===r||(Ri(),vu(e,r));;)try{Nu();break}catch(t){bu(e,t)}if(Xa(),wi.current=l,xi=a,null!==ji?r=0:(ki=null,Ti=0,r=Di),0!=(zi&_i))vu(e,0);else if(0!==r){if(2===r&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(n=Ut(e))&&(r=Eu(e,n))),1===r)throw t=Oi,vu(e,0),du(e,n),cu(e,Ya()),t;switch(e.finishedWork=e.current.alternate,e.finishedLanes=n,r){case 0:case 1:throw Error(o(345));case 2:xu(e);break;case 3:if(du(e,n),(62914560&n)===n&&10<(r=Yi+500-Ya())){if(0!==Pt(e,0))break;if(((a=e.suspendedLanes)&n)!==n){ou(),e.pingedLanes|=e.suspendedLanes&a;break}e.timeoutHandle=Rr(xu.bind(null,e),r);break}xu(e);break;case 4:if(du(e,n),(4186112&n)===n)break;for(r=e.eventTimes,a=-1;0<n;){var i=31-Vt(n);l=1<<i,(i=r[i])>a&&(a=i),n&=~l}if(n=a,10<(n=(120>(n=Ya()-n)?120:480>n?480:1080>n?1080:1920>n?1920:3e3>n?3e3:4320>n?4320:1960*Ni(n/1960))-n)){e.timeoutHandle=Rr(xu.bind(null,e),n);break}xu(e);break;case 5:xu(e);break;default:throw Error(o(329))}}return cu(e,Ya()),e.callbackNode===t?fu.bind(null,e):null}function du(e,t){for(t&=~Pi,t&=~_i,e.suspendedLanes|=t,e.pingedLanes&=~t,e=e.expirationTimes;0<t;){var n=31-Vt(t),r=1<<n;e[n]=-1,t&=~r}}function pu(e){if(0!=(48&xi))throw Error(o(327));if(Tu(),e===ki&&0!=(e.expiredLanes&Ti)){var t=Ti,n=Eu(e,t);0!=(zi&_i)&&(n=Eu(e,t=Pt(e,t)))}else n=Eu(e,t=Pt(e,0));if(0!==e.tag&&2===n&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(t=Ut(e))&&(n=Eu(e,t))),1===n)throw n=Oi,vu(e,0),du(e,t),cu(e,Ya()),n;return e.finishedWork=e.current.alternate,e.finishedLanes=t,xu(e),cu(e,Ya()),null}function yu(e,t){var n=xi;xi|=1;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function hu(e,t){var n=xi;xi&=-2,xi|=8;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function gu(e,t){ia(Ii,Ci),Ci|=t,zi|=t}function mu(){Ci=Ii.current,oa(Ii)}function vu(e,t){e.finishedWork=null,e.finishedLanes=0;var n=e.timeoutHandle;if(-1!==n&&(e.timeoutHandle=-1,Fr(n)),null!==ji)for(n=ji.return;null!==n;){var r=n;switch(r.tag){case 1:null!=(r=r.type.childContextTypes)&&ya();break;case 3:Cl(),oa(ca),oa(sa),Wl();break;case 5:Dl(r);break;case 4:Cl();break;case 13:case 19:oa(Ol);break;case 10:Ja(r);break;case 23:case 24:mu()}n=n.return}ki=e,ji=Qu(e.current,null),Ti=Ci=zi=t,Di=0,Oi=null,Pi=_i=Ai=0}function bu(e,t){for(;;){var n=ji;try{if(Xa(),Hl.current=jo,Xl){for(var r=$l.memoizedState;null!==r;){var a=r.queue;null!==a&&(a.pending=null),r=r.next}Xl=!1}if(Gl=0,Zl=ql=$l=null,Jl=!1,Si.current=null,null===n||null===n.return){Di=1,Oi=t,ji=null;break}e:{var l=e,o=n.return,i=n,u=t;if(t=Ti,i.flags|=2048,i.firstEffect=i.lastEffect=null,null!==u&&"object"==typeof u&&"function"==typeof u.then){var s=u;if(0==(2&i.mode)){var c=i.alternate;c?(i.updateQueue=c.updateQueue,i.memoizedState=c.memoizedState,i.lanes=c.lanes):(i.updateQueue=null,i.memoizedState=null)}var f=0!=(1&Ol.current),d=o;do{var p;if(p=13===d.tag){var y=d.memoizedState;if(null!==y)p=null!==y.dehydrated;else{var h=d.memoizedProps;p=void 0!==h.fallback&&(!0!==h.unstable_avoidThisFallback||!f)}}if(p){var g=d.updateQueue;if(null===g){var m=new Set;m.add(s),d.updateQueue=m}else g.add(s);if(0==(2&d.mode)){if(d.flags|=64,i.flags|=16384,i.flags&=-2981,1===i.tag)if(null===i.alternate)i.tag=17;else{var v=ol(-1,1);v.tag=2,il(i,v)}i.lanes|=1;break e}u=void 0,i=t;var b=l.pingCache;if(null===b?(b=l.pingCache=new li,u=new Set,b.set(s,u)):void 0===(u=b.get(s))&&(u=new Set,b.set(s,u)),!u.has(i)){u.add(i);var M=Au.bind(null,l,s,i);s.then(M,M)}d.flags|=4096,d.lanes=t;break e}d=d.return}while(null!==d);u=Error((K(i.type)||"A React component")+" suspended while rendering, but no fallback UI was specified.\n\nAdd a <Suspense fallback=...> component higher in the tree to provide a loading indicator or placeholder to display.")}5!==Di&&(Di=2),u=ri(u,i),d=o;do{switch(d.tag){case 3:l=u,d.flags|=4096,t&=-t,d.lanes|=t,ul(d,oi(0,l,t));break e;case 1:l=u;var E=d.type,L=d.stateNode;if(0==(64&d.flags)&&("function"==typeof E.getDerivedStateFromError||null!==L&&"function"==typeof L.componentDidCatch&&(null===Hi||!Hi.has(L)))){d.flags|=4096,t&=-t,d.lanes|=t,ul(d,ii(d,l,t));break e}}d=d.return}while(null!==d)}Su(n)}catch(e){t=e,ji===n&&null!==n&&(ji=n=n.return);continue}break}}function Mu(){var e=wi.current;return wi.current=jo,null===e?jo:e}function Eu(e,t){var n=xi;xi|=16;var r=Mu();for(ki===e&&Ti===t||vu(e,t);;)try{Lu();break}catch(t){bu(e,t)}if(Xa(),xi=n,wi.current=r,null!==ji)throw Error(o(261));return ki=null,Ti=0,Di}function Lu(){for(;null!==ji;)wu(ji)}function Nu(){for(;null!==ji&&!wa();)wu(ji)}function wu(e){var t=Fi(e.alternate,e,Ci);e.memoizedProps=e.pendingProps,null===t?Su(e):ji=t,Si.current=null}function Su(e){var t=e;do{var n=t.alternate;if(e=t.return,0==(2048&t.flags)){if(null!==(n=ti(n,t,Ci)))return void(ji=n);if(24!==(n=t).tag&&23!==n.tag||null===n.memoizedState||0!=(1073741824&Ci)||0==(4&n.mode)){for(var r=0,a=n.child;null!==a;)r|=a.lanes|a.childLanes,a=a.sibling;n.childLanes=r}null!==e&&0==(2048&e.flags)&&(null===e.firstEffect&&(e.firstEffect=t.firstEffect),null!==t.lastEffect&&(null!==e.lastEffect&&(e.lastEffect.nextEffect=t.firstEffect),e.lastEffect=t.lastEffect),1<t.flags&&(null!==e.lastEffect?e.lastEffect.nextEffect=t:e.firstEffect=t,e.lastEffect=t))}else{if(null!==(n=ni(t)))return n.flags&=2047,void(ji=n);null!==e&&(e.firstEffect=e.lastEffect=null,e.flags|=2048)}if(null!==(t=t.sibling))return void(ji=t);ji=t=e}while(null!==t);0===Di&&(Di=5)}function xu(e){var t=Qa();return Fa(99,ku.bind(null,e,t)),null}function ku(e,t){do{Tu()}while(null!==Gi);if(0!=(48&xi))throw Error(o(327));var n=e.finishedWork;if(null===n)return null;if(e.finishedWork=null,e.finishedLanes=0,n===e.current)throw Error(o(177));e.callbackNode=null;var r=n.lanes|n.childLanes,a=r,l=e.pendingLanes&~a;e.pendingLanes=a,e.suspendedLanes=0,e.pingedLanes=0,e.expiredLanes&=a,e.mutableReadLanes&=a,e.entangledLanes&=a,a=e.entanglements;for(var i=e.eventTimes,u=e.expirationTimes;0<l;){var s=31-Vt(l),c=1<<s;a[s]=0,i[s]=-1,u[s]=-1,l&=~c}if(null!==Xi&&0==(24&r)&&Xi.has(e)&&Xi.delete(e),e===ki&&(ji=ki=null,Ti=0),1<n.flags?null!==n.lastEffect?(n.lastEffect.nextEffect=n,r=n.firstEffect):r=n:r=n.firstEffect,null!==r){if(a=xi,xi|=32,Si.current=null,Pr=Gt,pr(i=dr())){if("selectionStart"in i)u={start:i.selectionStart,end:i.selectionEnd};else e:if(u=(u=i.ownerDocument)&&u.defaultView||window,(c=u.getSelection&&u.getSelection())&&0!==c.rangeCount){u=c.anchorNode,l=c.anchorOffset,s=c.focusNode,c=c.focusOffset;try{u.nodeType,s.nodeType}catch(e){u=null;break e}var f=0,d=-1,p=-1,y=0,h=0,g=i,m=null;t:for(;;){for(var v;g!==u||0!==l&&3!==g.nodeType||(d=f+l),g!==s||0!==c&&3!==g.nodeType||(p=f+c),3===g.nodeType&&(f+=g.nodeValue.length),null!==(v=g.firstChild);)m=g,g=v;for(;;){if(g===i)break t;if(m===u&&++y===l&&(d=f),m===s&&++h===c&&(p=f),null!==(v=g.nextSibling))break;m=(g=m).parentNode}g=v}u=-1===d||-1===p?null:{start:d,end:p}}else u=null;u=u||{start:0,end:0}}else u=null;Ur={focusedElem:i,selectionRange:u},Gt=!1,au=null,lu=!1,Vi=r;do{try{ju()}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);au=null,Vi=r;do{try{for(i=e;null!==Vi;){var b=Vi.flags;if(16&b&&me(Vi.stateNode,""),128&b){var M=Vi.alternate;if(null!==M){var E=M.ref;null!==E&&("function"==typeof E?E(null):E.current=null)}}switch(1038&b){case 2:gi(Vi),Vi.flags&=-3;break;case 6:gi(Vi),Vi.flags&=-3,Mi(Vi.alternate,Vi);break;case 1024:Vi.flags&=-1025;break;case 1028:Vi.flags&=-1025,Mi(Vi.alternate,Vi);break;case 4:Mi(Vi.alternate,Vi);break;case 8:bi(i,u=Vi);var L=u.alternate;yi(u),null!==L&&yi(L)}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);if(E=Ur,M=dr(),b=E.focusedElem,i=E.selectionRange,M!==b&&b&&b.ownerDocument&&fr(b.ownerDocument.documentElement,b)){null!==i&&pr(b)&&(M=i.start,void 0===(E=i.end)&&(E=M),"selectionStart"in b?(b.selectionStart=M,b.selectionEnd=Math.min(E,b.value.length)):(E=(M=b.ownerDocument||document)&&M.defaultView||window).getSelection&&(E=E.getSelection(),u=b.textContent.length,L=Math.min(i.start,u),i=void 0===i.end?L:Math.min(i.end,u),!E.extend&&L>i&&(u=i,i=L,L=u),u=cr(b,L),l=cr(b,i),u&&l&&(1!==E.rangeCount||E.anchorNode!==u.node||E.anchorOffset!==u.offset||E.focusNode!==l.node||E.focusOffset!==l.offset)&&((M=M.createRange()).setStart(u.node,u.offset),E.removeAllRanges(),L>i?(E.addRange(M),E.extend(l.node,l.offset)):(M.setEnd(l.node,l.offset),E.addRange(M))))),M=[];for(E=b;E=E.parentNode;)1===E.nodeType&&M.push({element:E,left:E.scrollLeft,top:E.scrollTop});for("function"==typeof b.focus&&b.focus(),b=0;b<M.length;b++)(E=M[b]).element.scrollLeft=E.left,E.element.scrollTop=E.top}Gt=!!Pr,Ur=Pr=null,e.current=n,Vi=r;do{try{for(b=e;null!==Vi;){var N=Vi.flags;if(36&N&&fi(b,Vi.alternate,Vi),128&N){M=void 0;var w=Vi.ref;if(null!==w){var S=Vi.stateNode;switch(Vi.tag){case 5:M=S;break;default:M=S}"function"==typeof w?w(M):w.current=M}}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);Vi=null,za(),xi=a}else e.current=n;if(Ki)Ki=!1,Gi=e,$i=t;else for(Vi=r;null!==Vi;)t=Vi.nextEffect,Vi.nextEffect=null,8&Vi.flags&&((N=Vi).sibling=null,N.stateNode=null),Vi=t;if(0===(r=e.pendingLanes)&&(Hi=null),1===r?e===eu?Ji++:(Ji=0,eu=e):Ji=0,n=n.stateNode,Ma&&"function"==typeof Ma.onCommitFiberRoot)try{Ma.onCommitFiberRoot(ba,n,void 0,64==(64&n.current.flags))}catch(e){}if(cu(e,Ya()),Bi)throw Bi=!1,e=Wi,Wi=null,e;return 0!=(8&xi)||Ba(),null}function ju(){for(;null!==Vi;){var e=Vi.alternate;lu||null===au||(0!=(8&Vi.flags)?Je(Vi,au)&&(lu=!0):13===Vi.tag&&Li(e,Vi)&&Je(Vi,au)&&(lu=!0));var t=Vi.flags;0!=(256&t)&&ci(e,Vi),0==(512&t)||Ki||(Ki=!0,Va(97,(function(){return Tu(),null}))),Vi=Vi.nextEffect}}function Tu(){if(90!==$i){var e=97<$i?97:$i;return $i=90,Fa(e,Du)}return!1}function Cu(e,t){qi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Iu(e,t){Zi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Du(){if(null===Gi)return!1;var e=Gi;if(Gi=null,0!=(48&xi))throw Error(o(331));var t=xi;xi|=32;var n=Zi;Zi=[];for(var r=0;r<n.length;r+=2){var a=n[r],l=n[r+1],i=a.destroy;if(a.destroy=void 0,"function"==typeof i)try{i()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(n=qi,qi=[],r=0;r<n.length;r+=2){a=n[r],l=n[r+1];try{var u=a.create;a.destroy=u()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(u=e.current.firstEffect;null!==u;)e=u.nextEffect,u.nextEffect=null,8&u.flags&&(u.sibling=null,u.stateNode=null),u=e;return xi=t,Ba(),!0}function Ou(e,t,n){il(e,t=oi(0,t=ri(n,t),1)),t=ou(),null!==(e=su(e,1))&&(Ft(e,1,t),cu(e,t))}function zu(e,t){if(3===e.tag)Ou(e,e,t);else for(var n=e.return;null!==n;){if(3===n.tag){Ou(n,e,t);break}if(1===n.tag){var r=n.stateNode;if("function"==typeof n.type.getDerivedStateFromError||"function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r))){var a=ii(n,e=ri(t,e),1);if(il(n,a),a=ou(),null!==(n=su(n,1)))Ft(n,1,a),cu(n,a);else if("function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r)))try{r.componentDidCatch(t,e)}catch(e){}break}}n=n.return}}function Au(e,t,n){var r=e.pingCache;null!==r&&r.delete(t),t=ou(),e.pingedLanes|=e.suspendedLanes&n,ki===e&&(Ti&n)===n&&(4===Di||3===Di&&(62914560&Ti)===Ti&&500>Ya()-Yi?vu(e,0):Pi|=n),cu(e,t)}function _u(e,t){var n=e.stateNode;null!==n&&n.delete(t),0==(t=0)&&(0==(2&(t=e.mode))?t=1:0==(4&t)?t=99===Qa()?1:2:(0===nu&&(nu=zi),0===(t=Qt(62914560&~nu))&&(t=4194304))),n=ou(),null!==(e=su(e,t))&&(Ft(e,t,n),cu(e,n))}function Pu(e,t,n,r){this.tag=e,this.key=n,this.sibling=this.child=this.return=this.stateNode=this.type=this.elementType=null,this.index=0,this.ref=null,this.pendingProps=t,this.dependencies=this.memoizedState=this.updateQueue=this.memoizedProps=null,this.mode=r,this.flags=0,this.lastEffect=this.firstEffect=this.nextEffect=null,this.childLanes=this.lanes=0,this.alternate=null}function Uu(e,t,n,r){return new Pu(e,t,n,r)}function Yu(e){return!(!(e=e.prototype)||!e.isReactComponent)}function Qu(e,t){var n=e.alternate;return null===n?((n=Uu(e.tag,t,e.key,e.mode)).elementType=e.elementType,n.type=e.type,n.stateNode=e.stateNode,n.alternate=e,e.alternate=n):(n.pendingProps=t,n.type=e.type,n.flags=0,n.nextEffect=null,n.firstEffect=null,n.lastEffect=null),n.childLanes=e.childLanes,n.lanes=e.lanes,n.child=e.child,n.memoizedProps=e.memoizedProps,n.memoizedState=e.memoizedState,n.updateQueue=e.updateQueue,t=e.dependencies,n.dependencies=null===t?null:{lanes:t.lanes,firstContext:t.firstContext},n.sibling=e.sibling,n.index=e.index,n.ref=e.ref,n}function Ru(e,t,n,r,a,l){var i=2;if(r=e,"function"==typeof e)Yu(e)&&(i=1);else if("string"==typeof e)i=5;else e:switch(e){case w:return Fu(n.children,a,l,t);case _:i=8,a|=16;break;case S:i=8,a|=1;break;case x:return(e=Uu(12,n,t,8|a)).elementType=x,e.type=x,e.lanes=l,e;case C:return(e=Uu(13,n,t,a)).type=C,e.elementType=C,e.lanes=l,e;case I:return(e=Uu(19,n,t,a)).elementType=I,e.lanes=l,e;case P:return Vu(n,a,l,t);case U:return(e=Uu(24,n,t,a)).elementType=U,e.lanes=l,e;default:if("object"==typeof e&&null!==e)switch(e.$$typeof){case k:i=10;break e;case j:i=9;break e;case T:i=11;break e;case D:i=14;break e;case O:i=16,r=null;break e;case z:i=22;break e}throw Error(o(130,null==e?e:typeof e,""))}return(t=Uu(i,n,t,a)).elementType=e,t.type=r,t.lanes=l,t}function Fu(e,t,n,r){return(e=Uu(7,e,r,t)).lanes=n,e}function Vu(e,t,n,r){return(e=Uu(23,e,r,t)).elementType=P,e.lanes=n,e}function Bu(e,t,n){return(e=Uu(6,e,null,t)).lanes=n,e}function Wu(e,t,n){return(t=Uu(4,null!==e.children?e.children:[],e.key,t)).lanes=n,t.stateNode={containerInfo:e.containerInfo,pendingChildren:null,implementation:e.implementation},t}function Hu(e,t,n){this.tag=t,this.containerInfo=e,this.finishedWork=this.pingCache=this.current=this.pendingChildren=null,this.timeoutHandle=-1,this.pendingContext=this.context=null,this.hydrate=n,this.callbackNode=null,this.callbackPriority=0,this.eventTimes=Rt(0),this.expirationTimes=Rt(-1),this.entangledLanes=this.finishedLanes=this.mutableReadLanes=this.expiredLanes=this.pingedLanes=this.suspendedLanes=this.pendingLanes=0,this.entanglements=Rt(0),this.mutableSourceEagerHydrationData=null}function Ku(e,t,n){var r=3<arguments.length&&void 0!==arguments[3]?arguments[3]:null;return{$$typeof:N,key:null==r?null:""+r,children:e,containerInfo:t,implementation:n}}function Gu(e,t,n,r){var a=t.current,l=ou(),i=iu(a);e:if(n){t:{if($e(n=n._reactInternals)!==n||1!==n.tag)throw Error(o(170));var u=n;do{switch(u.tag){case 3:u=u.stateNode.context;break t;case 1:if(pa(u.type)){u=u.stateNode.__reactInternalMemoizedMergedChildContext;break t}}u=u.return}while(null!==u);throw Error(o(171))}if(1===n.tag){var s=n.type;if(pa(s)){n=ga(n,s,u);break e}}n=u}else n=ua;return null===t.context?t.context=n:t.pendingContext=n,(t=ol(l,i)).payload={element:e},null!==(r=void 0===r?null:r)&&(t.callback=r),il(a,t),uu(a,i,l),i}function $u(e){if(!(e=e.current).child)return null;switch(e.child.tag){case 5:default:return e.child.stateNode}}function qu(e,t){if(null!==(e=e.memoizedState)&&null!==e.dehydrated){var n=e.retryLane;e.retryLane=0!==n&&n<t?n:t}}function Zu(e,t){qu(e,t),(e=e.alternate)&&qu(e,t)}function Xu(e,t,n){var r=null!=n&&null!=n.hydrationOptions&&n.hydrationOptions.mutableSources||null;if(n=new Hu(e,t,null!=n&&!0===n.hydrate),t=Uu(3,null,null,2===t?7:1===t?3:0),n.current=t,t.stateNode=n,al(t),e[qr]=n.current,jr(8===e.nodeType?e.parentNode:e),r)for(e=0;e<r.length;e++){var a=(t=r[e])._getVersion;a=a(t._source),null==n.mutableSourceEagerHydrationData?n.mutableSourceEagerHydrationData=[t,a]:n.mutableSourceEagerHydrationData.push(t,a)}this._internalRoot=n}function Ju(e){return!(!e||1!==e.nodeType&&9!==e.nodeType&&11!==e.nodeType&&(8!==e.nodeType||" react-mount-point-unstable "!==e.nodeValue))}function es(e,t,n,r,a){var l=n._reactRootContainer;if(l){var o=l._internalRoot;if("function"==typeof a){var i=a;a=function(){var e=$u(o);i.call(e)}}Gu(t,o,e,a)}else{if(l=n._reactRootContainer=function(e,t){if(t||(t=!(!(t=e?9===e.nodeType?e.documentElement:e.firstChild:null)||1!==t.nodeType||!t.hasAttribute("data-reactroot"))),!t)for(var n;n=e.lastChild;)e.removeChild(n);return new Xu(e,0,t?{hydrate:!0}:void 0)}(n,r),o=l._internalRoot,"function"==typeof a){var u=a;a=function(){var e=$u(o);u.call(e)}}hu((function(){Gu(t,o,e,a)}))}return $u(o)}function ts(e,t){var n=2<arguments.length&&void 0!==arguments[2]?arguments[2]:null;if(!Ju(t))throw Error(o(200));return Ku(e,t,null,n)}Fi=function(e,t,n){var r=t.lanes;if(null!==e)if(e.memoizedProps!==t.pendingProps||ca.current)Oo=!0;else{if(0==(n&r)){switch(Oo=!1,t.tag){case 3:Vo(t),Vl();break;case 5:Il(t);break;case 1:pa(t.type)&&ma(t);break;case 4:Tl(t,t.stateNode.containerInfo);break;case 10:r=t.memoizedProps.value;var a=t.type._context;ia(Ga,a._currentValue),a._currentValue=r;break;case 13:if(null!==t.memoizedState)return 0!=(n&t.child.childLanes)?Go(e,t,n):(ia(Ol,1&Ol.current),null!==(t=Jo(e,t,n))?t.sibling:null);ia(Ol,1&Ol.current);break;case 19:if(r=0!=(n&t.childLanes),0!=(64&e.flags)){if(r)return Xo(e,t,n);t.flags|=64}if(null!==(a=t.memoizedState)&&(a.rendering=null,a.tail=null,a.lastEffect=null),ia(Ol,Ol.current),r)break;return null;case 23:case 24:return t.lanes=0,Uo(e,t,n)}return Jo(e,t,n)}Oo=0!=(16384&e.flags)}else Oo=!1;switch(t.lanes=0,t.tag){case 2:if(r=t.type,null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=da(t,sa.current),tl(t,n),a=no(null,t,r,e,a,n),t.flags|=1,"object"==typeof a&&null!==a&&"function"==typeof a.render&&void 0===a.$$typeof){if(t.tag=1,t.memoizedState=null,t.updateQueue=null,pa(r)){var l=!0;ma(t)}else l=!1;t.memoizedState=null!==a.state&&void 0!==a.state?a.state:null,al(t);var i=r.getDerivedStateFromProps;"function"==typeof i&&dl(t,r,i,e),a.updater=pl,t.stateNode=a,a._reactInternals=t,ml(t,r,e,n),t=Fo(null,t,r,!0,l,n)}else t.tag=0,zo(null,t,a,n),t=t.child;return t;case 16:a=t.elementType;e:{switch(null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=(l=a._init)(a._payload),t.type=a,l=t.tag=function(e){if("function"==typeof e)return Yu(e)?1:0;if(null!=e){if((e=e.$$typeof)===T)return 11;if(e===D)return 14}return 2}(a),e=Ka(a,e),l){case 0:t=Qo(null,t,a,e,n);break e;case 1:t=Ro(null,t,a,e,n);break e;case 11:t=Ao(null,t,a,e,n);break e;case 14:t=_o(null,t,a,Ka(a.type,e),r,n);break e}throw Error(o(306,a,""))}return t;case 0:return r=t.type,a=t.pendingProps,Qo(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 1:return r=t.type,a=t.pendingProps,Ro(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 3:if(Vo(t),r=t.updateQueue,null===e||null===r)throw Error(o(282));if(r=t.pendingProps,a=null!==(a=t.memoizedState)?a.element:null,ll(e,t),sl(t,r,null,n),(r=t.memoizedState.element)===a)Vl(),t=Jo(e,t,n);else{if((l=(a=t.stateNode).hydrate)&&(_l=Br(t.stateNode.containerInfo.firstChild),Al=t,l=Pl=!0),l){if(null!=(e=a.mutableSourceEagerHydrationData))for(a=0;a<e.length;a+=2)(l=e[a])._workInProgressVersionPrimary=e[a+1],Bl.push(l);for(n=Nl(t,null,r,n),t.child=n;n;)n.flags=-3&n.flags|1024,n=n.sibling}else zo(e,t,r,n),Vl();t=t.child}return t;case 5:return Il(t),null===e&&Ql(t),r=t.type,a=t.pendingProps,l=null!==e?e.memoizedProps:null,i=a.children,Qr(r,a)?i=null:null!==l&&Qr(r,l)&&(t.flags|=16),Yo(e,t),zo(e,t,i,n),t.child;case 6:return null===e&&Ql(t),null;case 13:return Go(e,t,n);case 4:return Tl(t,t.stateNode.containerInfo),r=t.pendingProps,null===e?t.child=Ll(t,null,r,n):zo(e,t,r,n),t.child;case 11:return r=t.type,a=t.pendingProps,Ao(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 7:return zo(e,t,t.pendingProps,n),t.child;case 8:case 12:return zo(e,t,t.pendingProps.children,n),t.child;case 10:e:{r=t.type._context,a=t.pendingProps,i=t.memoizedProps,l=a.value;var u=t.type._context;if(ia(Ga,u._currentValue),u._currentValue=l,null!==i)if(u=i.value,0==(l=or(u,l)?0:0|("function"==typeof r._calculateChangedBits?r._calculateChangedBits(u,l):1073741823))){if(i.children===a.children&&!ca.current){t=Jo(e,t,n);break e}}else for(null!==(u=t.child)&&(u.return=t);null!==u;){var s=u.dependencies;if(null!==s){i=u.child;for(var c=s.firstContext;null!==c;){if(c.context===r&&0!=(c.observedBits&l)){1===u.tag&&((c=ol(-1,n&-n)).tag=2,il(u,c)),u.lanes|=n,null!==(c=u.alternate)&&(c.lanes|=n),el(u.return,n),s.lanes|=n;break}c=c.next}}else i=10===u.tag&&u.type===t.type?null:u.child;if(null!==i)i.return=u;else for(i=u;null!==i;){if(i===t){i=null;break}if(null!==(u=i.sibling)){u.return=i.return,i=u;break}i=i.return}u=i}zo(e,t,a.children,n),t=t.child}return t;case 9:return a=t.type,r=(l=t.pendingProps).children,tl(t,n),r=r(a=nl(a,l.unstable_observedBits)),t.flags|=1,zo(e,t,r,n),t.child;case 14:return l=Ka(a=t.type,t.pendingProps),_o(e,t,a,l=Ka(a.type,l),r,n);case 15:return Po(e,t,t.type,t.pendingProps,r,n);case 17:return r=t.type,a=t.pendingProps,a=t.elementType===r?a:Ka(r,a),null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),t.tag=1,pa(r)?(e=!0,ma(t)):e=!1,tl(t,n),hl(t,r,a),ml(t,r,a,n),Fo(null,t,r,!0,e,n);case 19:return Xo(e,t,n);case 23:case 24:return Uo(e,t,n)}throw Error(o(156,t.tag))},Xu.prototype.render=function(e){Gu(e,this._internalRoot,null,null)},Xu.prototype.unmount=function(){var e=this._internalRoot,t=e.containerInfo;Gu(null,e,null,(function(){t[qr]=null}))},et=function(e){13===e.tag&&(uu(e,4,ou()),Zu(e,4))},tt=function(e){13===e.tag&&(uu(e,67108864,ou()),Zu(e,67108864))},nt=function(e){if(13===e.tag){var t=ou(),n=iu(e);uu(e,n,t),Zu(e,n)}},rt=function(e,t){return t()},xe=function(e,t,n){switch(t){case"input":if(ne(e,n),t=n.name,"radio"===n.type&&null!=t){for(n=e;n.parentNode;)n=n.parentNode;for(n=n.querySelectorAll("input[name="+JSON.stringify(""+t)+'][type="radio"]'),t=0;t<n.length;t++){var r=n[t];if(r!==e&&r.form===e.form){var a=ta(r);if(!a)throw Error(o(90));Z(r),ne(r,a)}}}break;case"textarea":se(e,n);break;case"select":null!=(t=n.value)&&oe(e,!!n.multiple,t,!1)}},De=yu,Oe=function(e,t,n,r,a){var l=xi;xi|=4;try{return Fa(98,e.bind(null,t,n,r,a))}finally{0===(xi=l)&&(Ri(),Ba())}},ze=function(){0==(49&xi)&&(function(){if(null!==Xi){var e=Xi;Xi=null,e.forEach((function(e){e.expiredLanes|=24&e.pendingLanes,cu(e,Ya())}))}Ba()}(),Tu())},Ae=function(e,t){var n=xi;xi|=2;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}};var ns={Events:[Jr,ea,ta,Ce,Ie,Tu,{current:!1}]},rs={findFiberByHostInstance:Xr,bundleType:0,version:"17.0.2",rendererPackageName:"react-dom"},as={bundleType:rs.bundleType,version:rs.version,rendererPackageName:rs.rendererPackageName,rendererConfig:rs.rendererConfig,overrideHookState:null,overrideHookStateDeletePath:null,overrideHookStateRenamePath:null,overrideProps:null,overridePropsDeletePath:null,overridePropsRenamePath:null,setSuspenseHandler:null,scheduleUpdate:null,currentDispatcherRef:E.ReactCurrentDispatcher,findHostInstanceByFiber:function(e){return null===(e=Xe(e))?null:e.stateNode},findFiberByHostInstance:rs.findFiberByHostInstance||function(){return null},findHostInstancesForRefresh:null,scheduleRefresh:null,scheduleRoot:null,setRefreshHandler:null,getCurrentFiber:null};if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__){var ls=__REACT_DEVTOOLS_GLOBAL_HOOK__;if(!ls.isDisabled&&ls.supportsFiber)try{ba=ls.inject(as),Ma=ls}catch(he){}}t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=ns,t.createPortal=ts,t.findDOMNode=function(e){if(null==e)return null;if(1===e.nodeType)return e;var t=e._reactInternals;if(void 0===t){if("function"==typeof e.render)throw Error(o(188));throw Error(o(268,Object.keys(e)))}return null===(e=Xe(t))?null:e.stateNode},t.flushSync=function(e,t){var n=xi;if(0!=(48&n))return e(t);xi|=1;try{if(e)return Fa(99,e.bind(null,t))}finally{xi=n,Ba()}},t.hydrate=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!0,n)},t.render=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!1,n)},t.unmountComponentAtNode=function(e){if(!Ju(e))throw Error(o(40));return!!e._reactRootContainer&&(hu((function(){es(null,null,e,!1,(function(){e._reactRootContainer=null,e[qr]=null}))})),!0)},t.unstable_batchedUpdates=yu,t.unstable_createPortal=function(e,t){return ts(e,t,2<arguments.length&&void 0!==arguments[2]?arguments[2]:null)},t.unstable_renderSubtreeIntoContainer=function(e,t,n,r){if(!Ju(n))throw Error(o(200));if(null==e||void 0===e._reactInternals)throw Error(o(38));return es(e,t,n,!1,r)},t.version="17.0.2"},935:(e,t,n)=>{"use strict";!function e(){if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__&&"function"==typeof __REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE)try{__REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE(e)}catch(e){console.error(e)}}(),e.exports=n(448)},357:(e,t,n)=>{"use strict";function r(){return(r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e}).apply(this,arguments)}function a(e,t){if(null==e)return{};var n,r,a={},l=Object.keys(e);for(r=0;r<l.length;r++)n=l[r],t.indexOf(n)>=0||(a[n]=e[n]);return a}function l(e,t){return(l=Object.setPrototypeOf||function(e,t){return e.__proto__=t,e})(e,t)}function o(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,l(e,t)}function i(e,t){return e.replace(new RegExp("(^|\\s)"+t+"(?:\\s|$)","g"),"$1").replace(/\s+/g," ").replace(/^\s*|\s*$/g,"")}n.r(t),n.d(t,{CSSTransition:()=>N,ReplaceTransition:()=>I,SwitchTransition:()=>Q,Transition:()=>M,TransitionGroup:()=>T,config:()=>c});var u=n(294),s=n(935);const c={disabled:!1},f=u.createContext(null);var d=function(e){return e.scrollTop},p="unmounted",y="exited",h="entering",g="entered",m="exiting",v=function(e){function t(t,n){var r;r=e.call(this,t,n)||this;var a,l=n&&!n.isMounting?t.enter:t.appear;return r.appearStatus=null,t.in?l?(a=y,r.appearStatus=h):a=g:a=t.unmountOnExit||t.mountOnEnter?p:y,r.state={status:a},r.nextCallback=null,r}o(t,e),t.getDerivedStateFromProps=function(e,t){return e.in&&t.status===p?{status:y}:null};var n=t.prototype;return n.componentDidMount=function(){this.updateStatus(!0,this.appearStatus)},n.componentDidUpdate=function(e){var t=null;if(e!==this.props){var n=this.state.status;this.props.in?n!==h&&n!==g&&(t=h):n!==h&&n!==g||(t=m)}this.updateStatus(!1,t)},n.componentWillUnmount=function(){this.cancelNextCallback()},n.getTimeouts=function(){var e,t,n,r=this.props.timeout;return e=t=n=r,null!=r&&"number"!=typeof r&&(e=r.exit,t=r.enter,n=void 0!==r.appear?r.appear:t),{exit:e,enter:t,appear:n}},n.updateStatus=function(e,t){if(void 0===e&&(e=!1),null!==t)if(this.cancelNextCallback(),t===h){if(this.props.unmountOnExit||this.props.mountOnEnter){var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this);n&&d(n)}this.performEnter(e)}else this.performExit();else this.props.unmountOnExit&&this.state.status===y&&this.setState({status:p})},n.performEnter=function(e){var t=this,n=this.props.enter,r=this.context?this.context.isMounting:e,a=this.props.nodeRef?[r]:[s.findDOMNode(this),r],l=a[0],o=a[1],i=this.getTimeouts(),u=r?i.appear:i.enter;!e&&!n||c.disabled?this.safeSetState({status:g},(function(){t.props.onEntered(l)})):(this.props.onEnter(l,o),this.safeSetState({status:h},(function(){t.props.onEntering(l,o),t.onTransitionEnd(u,(function(){t.safeSetState({status:g},(function(){t.props.onEntered(l,o)}))}))})))},n.performExit=function(){var e=this,t=this.props.exit,n=this.getTimeouts(),r=this.props.nodeRef?void 0:s.findDOMNode(this);t&&!c.disabled?(this.props.onExit(r),this.safeSetState({status:m},(function(){e.props.onExiting(r),e.onTransitionEnd(n.exit,(function(){e.safeSetState({status:y},(function(){e.props.onExited(r)}))}))}))):this.safeSetState({status:y},(function(){e.props.onExited(r)}))},n.cancelNextCallback=function(){null!==this.nextCallback&&(this.nextCallback.cancel(),this.nextCallback=null)},n.safeSetState=function(e,t){t=this.setNextCallback(t),this.setState(e,t)},n.setNextCallback=function(e){var t=this,n=!0;return this.nextCallback=function(r){n&&(n=!1,t.nextCallback=null,e(r))},this.nextCallback.cancel=function(){n=!1},this.nextCallback},n.onTransitionEnd=function(e,t){this.setNextCallback(t);var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this),r=null==e&&!this.props.addEndListener;if(n&&!r){if(this.props.addEndListener){var a=this.props.nodeRef?[this.nextCallback]:[n,this.nextCallback],l=a[0],o=a[1];this.props.addEndListener(l,o)}null!=e&&setTimeout(this.nextCallback,e)}else setTimeout(this.nextCallback,0)},n.render=function(){var e=this.state.status;if(e===p)return null;var t=this.props,n=t.children,r=(t.in,t.mountOnEnter,t.unmountOnExit,t.appear,t.enter,t.exit,t.timeout,t.addEndListener,t.onEnter,t.onEntering,t.onEntered,t.onExit,t.onExiting,t.onExited,t.nodeRef,a(t,["children","in","mountOnEnter","unmountOnExit","appear","enter","exit","timeout","addEndListener","onEnter","onEntering","onEntered","onExit","onExiting","onExited","nodeRef"]));return u.createElement(f.Provider,{value:null},"function"==typeof n?n(e,r):u.cloneElement(u.Children.only(n),r))},t}(u.Component);function b(){}v.contextType=f,v.propTypes={},v.defaultProps={in:!1,mountOnEnter:!1,unmountOnExit:!1,appear:!1,enter:!0,exit:!0,onEnter:b,onEntering:b,onEntered:b,onExit:b,onExiting:b,onExited:b},v.UNMOUNTED=p,v.EXITED=y,v.ENTERING=h,v.ENTERED=g,v.EXITING=m;const M=v;var E=function(e,t){return e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.remove(r):"string"==typeof n.className?n.className=i(n.className,r):n.setAttribute("class",i(n.className&&n.className.baseVal||"",r)));var n,r}))},L=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).appliedClasses={appear:{},enter:{},exit:{}},t.onEnter=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1];t.removeClasses(a,"exit"),t.addClass(a,l?"appear":"enter","base"),t.props.onEnter&&t.props.onEnter(e,n)},t.onEntering=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.addClass(a,l,"active"),t.props.onEntering&&t.props.onEntering(e,n)},t.onEntered=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.removeClasses(a,l),t.addClass(a,l,"done"),t.props.onEntered&&t.props.onEntered(e,n)},t.onExit=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"appear"),t.removeClasses(n,"enter"),t.addClass(n,"exit","base"),t.props.onExit&&t.props.onExit(e)},t.onExiting=function(e){var n=t.resolveArguments(e)[0];t.addClass(n,"exit","active"),t.props.onExiting&&t.props.onExiting(e)},t.onExited=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"exit"),t.addClass(n,"exit","done"),t.props.onExited&&t.props.onExited(e)},t.resolveArguments=function(e,n){return t.props.nodeRef?[t.props.nodeRef.current,e]:[e,n]},t.getClassNames=function(e){var n=t.props.classNames,r="string"==typeof n,a=r?(r&&n?n+"-":"")+e:n[e];return{baseClassName:a,activeClassName:r?a+"-active":n[e+"Active"],doneClassName:r?a+"-done":n[e+"Done"]}},t}o(t,e);var n=t.prototype;return n.addClass=function(e,t,n){var r=this.getClassNames(t)[n+"ClassName"],a=this.getClassNames("enter").doneClassName;"appear"===t&&"done"===n&&a&&(r+=" "+a),"active"===n&&e&&d(e),r&&(this.appliedClasses[t][n]=r,function(e,t){e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.add(r):function(e,t){return e.classList?!!t&&e.classList.contains(t):-1!==(" "+(e.className.baseVal||e.className)+" ").indexOf(" "+t+" ")}(n,r)||("string"==typeof n.className?n.className=n.className+" "+r:n.setAttribute("class",(n.className&&n.className.baseVal||"")+" "+r)));var n,r}))}(e,r))},n.removeClasses=function(e,t){var n=this.appliedClasses[t],r=n.base,a=n.active,l=n.done;this.appliedClasses[t]={},r&&E(e,r),a&&E(e,a),l&&E(e,l)},n.render=function(){var e=this.props,t=(e.classNames,a(e,["classNames"]));return u.createElement(M,r({},t,{onEnter:this.onEnter,onEntered:this.onEntered,onEntering:this.onEntering,onExit:this.onExit,onExiting:this.onExiting,onExited:this.onExited}))},t}(u.Component);L.defaultProps={classNames:""},L.propTypes={};const N=L;function w(e,t){var n=Object.create(null);return e&&u.Children.map(e,(function(e){return e})).forEach((function(e){n[e.key]=function(e){return t&&(0,u.isValidElement)(e)?t(e):e}(e)})),n}function S(e,t,n){return null!=n[t]?n[t]:e.props[t]}function x(e,t,n){var r=w(e.children),a=function(e,t){function n(n){return n in t?t[n]:e[n]}e=e||{},t=t||{};var r,a=Object.create(null),l=[];for(var o in e)o in t?l.length&&(a[o]=l,l=[]):l.push(o);var i={};for(var u in t){if(a[u])for(r=0;r<a[u].length;r++){var s=a[u][r];i[a[u][r]]=n(s)}i[u]=n(u)}for(r=0;r<l.length;r++)i[l[r]]=n(l[r]);return i}(t,r);return Object.keys(a).forEach((function(l){var o=a[l];if((0,u.isValidElement)(o)){var i=l in t,s=l in r,c=t[l],f=(0,u.isValidElement)(c)&&!c.props.in;!s||i&&!f?s||!i||f?s&&i&&(0,u.isValidElement)(c)&&(a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:c.props.in,exit:S(o,"exit",e),enter:S(o,"enter",e)})):a[l]=(0,u.cloneElement)(o,{in:!1}):a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:!0,exit:S(o,"exit",e),enter:S(o,"enter",e)})}})),a}var k=Object.values||function(e){return Object.keys(e).map((function(t){return e[t]}))},j=function(e){function t(t,n){var r,a=(r=e.call(this,t,n)||this).handleExited.bind(function(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}(r));return r.state={contextValue:{isMounting:!0},handleExited:a,firstRender:!0},r}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.mounted=!0,this.setState({contextValue:{isMounting:!1}})},n.componentWillUnmount=function(){this.mounted=!1},t.getDerivedStateFromProps=function(e,t){var n,r,a=t.children,l=t.handleExited;return{children:t.firstRender?(n=e,r=l,w(n.children,(function(e){return(0,u.cloneElement)(e,{onExited:r.bind(null,e),in:!0,appear:S(e,"appear",n),enter:S(e,"enter",n),exit:S(e,"exit",n)})}))):x(e,a,l),firstRender:!1}},n.handleExited=function(e,t){var n=w(this.props.children);e.key in n||(e.props.onExited&&e.props.onExited(t),this.mounted&&this.setState((function(t){var n=r({},t.children);return delete n[e.key],{children:n}})))},n.render=function(){var e=this.props,t=e.component,n=e.childFactory,r=a(e,["component","childFactory"]),l=this.state.contextValue,o=k(this.state.children).map(n);return delete r.appear,delete r.enter,delete r.exit,null===t?u.createElement(f.Provider,{value:l},o):u.createElement(f.Provider,{value:l},u.createElement(t,r,o))},t}(u.Component);j.propTypes={},j.defaultProps={component:"div",childFactory:function(e){return e}};const T=j;var C=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).handleEnter=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEnter",0,n)},t.handleEntering=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntering",0,n)},t.handleEntered=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntered",0,n)},t.handleExit=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExit",1,n)},t.handleExiting=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExiting",1,n)},t.handleExited=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExited",1,n)},t}o(t,e);var n=t.prototype;return n.handleLifecycle=function(e,t,n){var r,a=this.props.children,l=u.Children.toArray(a)[t];if(l.props[e]&&(r=l.props)[e].apply(r,n),this.props[e]){var o=l.props.nodeRef?void 0:s.findDOMNode(this);this.props[e](o)}},n.render=function(){var e=this.props,t=e.children,n=e.in,r=a(e,["children","in"]),l=u.Children.toArray(t),o=l[0],i=l[1];return delete r.onEnter,delete r.onEntering,delete r.onEntered,delete r.onExit,delete r.onExiting,delete r.onExited,u.createElement(T,r,n?u.cloneElement(o,{key:"first",onEnter:this.handleEnter,onEntering:this.handleEntering,onEntered:this.handleEntered}):u.cloneElement(i,{key:"second",onEnter:this.handleExit,onEntering:this.handleExiting,onEntered:this.handleExited}))},t}(u.Component);C.propTypes={};const I=C;var D,O,z="out-in",A="in-out",_=function(e,t,n){return function(){var r;e.props[t]&&(r=e.props)[t].apply(r,arguments),n()}},P=((D={})["out-in"]=function(e){var t=e.current,n=e.changeState;return u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){n(h,null)}))})},D[A]=function(e){var t=e.current,n=e.changeState,r=e.children;return[t,u.cloneElement(r,{in:!0,onEntered:_(r,"onEntered",(function(){n(h)}))})]},D),U=((O={})["out-in"]=function(e){var t=e.children,n=e.changeState;return u.cloneElement(t,{in:!0,onEntered:_(t,"onEntered",(function(){n(g,u.cloneElement(t,{in:!0}))}))})},O[A]=function(e){var t=e.current,n=e.children,r=e.changeState;return[u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){r(g,u.cloneElement(n,{in:!0}))}))}),u.cloneElement(n,{in:!0})]},O),Y=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).state={status:g,current:null},t.appeared=!1,t.changeState=function(e,n){void 0===n&&(n=t.state.current),t.setState({status:e,current:n})},t}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.appeared=!0},t.getDerivedStateFromProps=function(e,t){return null==e.children?{current:null}:t.status===h&&e.mode===A?{status:h}:!t.current||((n=t.current)===(r=e.children)||u.isValidElement(n)&&u.isValidElement(r)&&null!=n.key&&n.key===r.key)?{current:u.cloneElement(e.children,{in:!0})}:{status:m};var n,r},n.render=function(){var e,t=this.props,n=t.children,r=t.mode,a=this.state,l=a.status,o=a.current,i={children:n,current:o,changeState:this.changeState,status:l};switch(l){case h:e=U[r](i);break;case m:e=P[r](i);break;case g:e=o}return u.createElement(f.Provider,{value:{isMounting:!this.appeared}},e)},t}(u.Component);Y.propTypes={},Y.defaultProps={mode:z};const Q=Y},408:(e,t,n)=>{"use strict";var r=n(418),a=60103,l=60106;t.Fragment=60107,t.StrictMode=60108,t.Profiler=60114;var o=60109,i=60110,u=60112;t.Suspense=60113;var s=60115,c=60116;if("function"==typeof Symbol&&Symbol.for){var f=Symbol.for;a=f("react.element"),l=f("react.portal"),t.Fragment=f("react.fragment"),t.StrictMode=f("react.strict_mode"),t.Profiler=f("react.profiler"),o=f("react.provider"),i=f("react.context"),u=f("react.forward_ref"),t.Suspense=f("react.suspense"),s=f("react.memo"),c=f("react.lazy")}var d="function"==typeof Symbol&&Symbol.iterator;function p(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}var y={isMounted:function(){return!1},enqueueForceUpdate:function(){},enqueueReplaceState:function(){},enqueueSetState:function(){}},h={};function g(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}function m(){}function v(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}g.prototype.isReactComponent={},g.prototype.setState=function(e,t){if("object"!=typeof e&&"function"!=typeof e&&null!=e)throw Error(p(85));this.updater.enqueueSetState(this,e,t,"setState")},g.prototype.forceUpdate=function(e){this.updater.enqueueForceUpdate(this,e,"forceUpdate")},m.prototype=g.prototype;var b=v.prototype=new m;b.constructor=v,r(b,g.prototype),b.isPureReactComponent=!0;var M={current:null},E=Object.prototype.hasOwnProperty,L={key:!0,ref:!0,__self:!0,__source:!0};function N(e,t,n){var r,l={},o=null,i=null;if(null!=t)for(r in void 0!==t.ref&&(i=t.ref),void 0!==t.key&&(o=""+t.key),t)E.call(t,r)&&!L.hasOwnProperty(r)&&(l[r]=t[r]);var u=arguments.length-2;if(1===u)l.children=n;else if(1<u){for(var s=Array(u),c=0;c<u;c++)s[c]=arguments[c+2];l.children=s}if(e&&e.defaultProps)for(r in u=e.defaultProps)void 0===l[r]&&(l[r]=u[r]);return{$$typeof:a,type:e,key:o,ref:i,props:l,_owner:M.current}}function w(e){return"object"==typeof e&&null!==e&&e.$$typeof===a}var S=/\/+/g;function x(e,t){return"object"==typeof e&&null!==e&&null!=e.key?function(e){var t={"=":"=0",":":"=2"};return"$"+e.replace(/[=:]/g,(function(e){return t[e]}))}(""+e.key):t.toString(36)}function k(e,t,n,r,o){var i=typeof e;"undefined"!==i&&"boolean"!==i||(e=null);var u=!1;if(null===e)u=!0;else switch(i){case"string":case"number":u=!0;break;case"object":switch(e.$$typeof){case a:case l:u=!0}}if(u)return o=o(u=e),e=""===r?"."+x(u,0):r,Array.isArray(o)?(n="",null!=e&&(n=e.replace(S,"$&/")+"/"),k(o,t,n,"",(function(e){return e}))):null!=o&&(w(o)&&(o=function(e,t){return{$$typeof:a,type:e.type,key:t,ref:e.ref,props:e.props,_owner:e._owner}}(o,n+(!o.key||u&&u.key===o.key?"":(""+o.key).replace(S,"$&/")+"/")+e)),t.push(o)),1;if(u=0,r=""===r?".":r+":",Array.isArray(e))for(var s=0;s<e.length;s++){var c=r+x(i=e[s],s);u+=k(i,t,n,c,o)}else if("function"==typeof(c=function(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=d&&e[d]||e["@iterator"])?e:null}(e)))for(e=c.call(e),s=0;!(i=e.next()).done;)u+=k(i=i.value,t,n,c=r+x(i,s++),o);else if("object"===i)throw t=""+e,Error(p(31,"[object Object]"===t?"object with keys {"+Object.keys(e).join(", ")+"}":t));return u}function j(e,t,n){if(null==e)return e;var r=[],a=0;return k(e,r,"","",(function(e){return t.call(n,e,a++)})),r}function T(e){if(-1===e._status){var t=e._result;t=t(),e._status=0,e._result=t,t.then((function(t){0===e._status&&(t=t.default,e._status=1,e._result=t)}),(function(t){0===e._status&&(e._status=2,e._result=t)}))}if(1===e._status)return e._result;throw e._result}var C={current:null};function I(){var e=C.current;if(null===e)throw Error(p(321));return e}var D={ReactCurrentDispatcher:C,ReactCurrentBatchConfig:{transition:0},ReactCurrentOwner:M,IsSomeRendererActing:{current:!1},assign:r};t.Children={map:j,forEach:function(e,t,n){j(e,(function(){t.apply(this,arguments)}),n)},count:function(e){var t=0;return j(e,(function(){t++})),t},toArray:function(e){return j(e,(function(e){return e}))||[]},only:function(e){if(!w(e))throw Error(p(143));return e}},t.Component=g,t.PureComponent=v,t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=D,t.cloneElement=function(e,t,n){if(null==e)throw Error(p(267,e));var l=r({},e.props),o=e.key,i=e.ref,u=e._owner;if(null!=t){if(void 0!==t.ref&&(i=t.ref,u=M.current),void 0!==t.key&&(o=""+t.key),e.type&&e.type.defaultProps)var s=e.type.defaultProps;for(c in t)E.call(t,c)&&!L.hasOwnProperty(c)&&(l[c]=void 0===t[c]&&void 0!==s?s[c]:t[c])}var c=arguments.length-2;if(1===c)l.children=n;else if(1<c){s=Array(c);for(var f=0;f<c;f++)s[f]=arguments[f+2];l.children=s}return{$$typeof:a,type:e.type,key:o,ref:i,props:l,_owner:u}},t.createContext=function(e,t){return void 0===t&&(t=null),(e={$$typeof:i,_calculateChangedBits:t,_currentValue:e,_currentValue2:e,_threadCount:0,Provider:null,Consumer:null}).Provider={$$typeof:o,_context:e},e.Consumer=e},t.createElement=N,t.createFactory=function(e){var t=N.bind(null,e);return t.type=e,t},t.createRef=function(){return{current:null}},t.forwardRef=function(e){return{$$typeof:u,render:e}},t.isValidElement=w,t.lazy=function(e){return{$$typeof:c,_payload:{_status:-1,_result:e},_init:T}},t.memo=function(e,t){return{$$typeof:s,type:e,compare:void 0===t?null:t}},t.useCallback=function(e,t){return I().useCallback(e,t)},t.useContext=function(e,t){return I().useContext(e,t)},t.useDebugValue=function(){},t.useEffect=function(e,t){return I().useEffect(e,t)},t.useImperativeHandle=function(e,t,n){return I().useImperativeHandle(e,t,n)},t.useLayoutEffect=function(e,t){return I().useLayoutEffect(e,t)},t.useMemo=function(e,t){return I().useMemo(e,t)},t.useReducer=function(e,t,n){return I().useReducer(e,t,n)},t.useRef=function(e){return I().useRef(e)},t.useState=function(e){return I().useState(e)},t.version="17.0.2"},294:(e,t,n)=>{"use strict";e.exports=n(408)},53:(e,t)=>{"use strict";var n,r,a,l;if("object"==typeof performance&&"function"==typeof performance.now){var o=performance;t.unstable_now=function(){return o.now()}}else{var i=Date,u=i.now();t.unstable_now=function(){return i.now()-u}}if("undefined"==typeof window||"function"!=typeof MessageChannel){var s=null,c=null,f=function(){if(null!==s)try{var e=t.unstable_now();s(!0,e),s=null}catch(e){throw setTimeout(f,0),e}};n=function(e){null!==s?setTimeout(n,0,e):(s=e,setTimeout(f,0))},r=function(e,t){c=setTimeout(e,t)},a=function(){clearTimeout(c)},t.unstable_shouldYield=function(){return!1},l=t.unstable_forceFrameRate=function(){}}else{var d=window.setTimeout,p=window.clearTimeout;if("undefined"!=typeof console){var y=window.cancelAnimationFrame;"function"!=typeof window.requestAnimationFrame&&console.error("This browser doesn't support requestAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills"),"function"!=typeof y&&console.error("This browser doesn't support cancelAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills")}var h=!1,g=null,m=-1,v=5,b=0;t.unstable_shouldYield=function(){return t.unstable_now()>=b},l=function(){},t.unstable_forceFrameRate=function(e){0>e||125<e?console.error("forceFrameRate takes a positive int between 0 and 125, forcing frame rates higher than 125 fps is not supported"):v=0<e?Math.floor(1e3/e):5};var M=new MessageChannel,E=M.port2;M.port1.onmessage=function(){if(null!==g){var e=t.unstable_now();b=e+v;try{g(!0,e)?E.postMessage(null):(h=!1,g=null)}catch(e){throw E.postMessage(null),e}}else h=!1},n=function(e){g=e,h||(h=!0,E.postMessage(null))},r=function(e,n){m=d((function(){e(t.unstable_now())}),n)},a=function(){p(m),m=-1}}function L(e,t){var n=e.length;e.push(t);e:for(;;){var r=n-1>>>1,a=e[r];if(!(void 0!==a&&0<S(a,t)))break e;e[r]=t,e[n]=a,n=r}}function N(e){return void 0===(e=e[0])?null:e}function w(e){var t=e[0];if(void 0!==t){var n=e.pop();if(n!==t){e[0]=n;e:for(var r=0,a=e.length;r<a;){var l=2*(r+1)-1,o=e[l],i=l+1,u=e[i];if(void 0!==o&&0>S(o,n))void 0!==u&&0>S(u,o)?(e[r]=u,e[i]=n,r=i):(e[r]=o,e[l]=n,r=l);else{if(!(void 0!==u&&0>S(u,n)))break e;e[r]=u,e[i]=n,r=i}}}return t}return null}function S(e,t){var n=e.sortIndex-t.sortIndex;return 0!==n?n:e.id-t.id}var x=[],k=[],j=1,T=null,C=3,I=!1,D=!1,O=!1;function z(e){for(var t=N(k);null!==t;){if(null===t.callback)w(k);else{if(!(t.startTime<=e))break;w(k),t.sortIndex=t.expirationTime,L(x,t)}t=N(k)}}function A(e){if(O=!1,z(e),!D)if(null!==N(x))D=!0,n(_);else{var t=N(k);null!==t&&r(A,t.startTime-e)}}function _(e,n){D=!1,O&&(O=!1,a()),I=!0;var l=C;try{for(z(n),T=N(x);null!==T&&(!(T.expirationTime>n)||e&&!t.unstable_shouldYield());){var o=T.callback;if("function"==typeof o){T.callback=null,C=T.priorityLevel;var i=o(T.expirationTime<=n);n=t.unstable_now(),"function"==typeof i?T.callback=i:T===N(x)&&w(x),z(n)}else w(x);T=N(x)}if(null!==T)var u=!0;else{var s=N(k);null!==s&&r(A,s.startTime-n),u=!1}return u}finally{T=null,C=l,I=!1}}var P=l;t.unstable_IdlePriority=5,t.unstable_ImmediatePriority=1,t.unstable_LowPriority=4,t.unstable_NormalPriority=3,t.unstable_Profiling=null,t.unstable_UserBlockingPriority=2,t.unstable_cancelCallback=function(e){e.callback=null},t.unstable_continueExecution=function(){D||I||(D=!0,n(_))},t.unstable_getCurrentPriorityLevel=function(){return C},t.unstable_getFirstCallbackNode=function(){return N(x)},t.unstable_next=function(e){switch(C){case 1:case 2:case 3:var t=3;break;default:t=C}var n=C;C=t;try{return e()}finally{C=n}},t.unstable_pauseExecution=function(){},t.unstable_requestPaint=P,t.unstable_runWithPriority=function(e,t){switch(e){case 1:case 2:case 3:case 4:case 5:break;default:e=3}var n=C;C=e;try{return t()}finally{C=n}},t.unstable_scheduleCallback=function(e,l,o){var i=t.unstable_now();switch(o="object"==typeof o&&null!==o&&"number"==typeof(o=o.delay)&&0<o?i+o:i,e){case 1:var u=-1;break;case 2:u=250;break;case 5:u=1073741823;break;case 4:u=1e4;break;default:u=5e3}return e={id:j++,callback:l,priorityLevel:e,startTime:o,expirationTime:u=o+u,sortIndex:-1},o>i?(e.sortIndex=o,L(k,e),null===N(x)&&e===N(k)&&(O?a():O=!0,r(A,o-i))):(e.sortIndex=u,L(x,e),D||I||(D=!0,n(_))),e},t.unstable_wrapCallback=function(e){var t=C;return function(){var n=C;C=t;try{return e.apply(this,arguments)}finally{C=n}}}},840:(e,t,n)=>{"use strict";e.exports=n(53)},188:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(151);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},413:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(148);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},810:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(908);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},454:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(174);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},379:(e,t,n)=>{"use strict";var r,a=function(){var e={};return function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}e[t]=n}return e[t]}}(),l=[];function o(e){for(var t=-1,n=0;n<l.length;n++)if(l[n].identifier===e){t=n;break}return t}function i(e,t){for(var n={},r=[],a=0;a<e.length;a++){var i=e[a],u=t.base?i[0]+t.base:i[0],s=n[u]||0,c="".concat(u," ").concat(s);n[u]=s+1;var f=o(c),d={css:i[1],media:i[2],sourceMap:i[3]};-1!==f?(l[f].references++,l[f].updater(d)):l.push({identifier:c,updater:h(d,t),references:1}),r.push(c)}return r}function u(e){var t=document.createElement("style"),r=e.attributes||{};if(void 0===r.nonce){var l=n.nc;l&&(r.nonce=l)}if(Object.keys(r).forEach((function(e){t.setAttribute(e,r[e])})),"function"==typeof e.insert)e.insert(t);else{var o=a(e.insert||"head");if(!o)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");o.appendChild(t)}return t}var s,c=(s=[],function(e,t){return s[e]=t,s.filter(Boolean).join("\n")});function f(e,t,n,r){var a=n?"":r.media?"@media ".concat(r.media," {").concat(r.css,"}"):r.css;if(e.styleSheet)e.styleSheet.cssText=c(t,a);else{var l=document.createTextNode(a),o=e.childNodes;o[t]&&e.removeChild(o[t]),o.length?e.insertBefore(l,o[t]):e.appendChild(l)}}function d(e,t,n){var r=n.css,a=n.media,l=n.sourceMap;if(a?e.setAttribute("media",a):e.removeAttribute("media"),l&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(l))))," */")),e.styleSheet)e.styleSheet.cssText=r;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(r))}}var p=null,y=0;function h(e,t){var n,r,a;if(t.singleton){var l=y++;n=p||(p=u(t)),r=f.bind(null,n,l,!1),a=f.bind(null,n,l,!0)}else n=u(t),r=d.bind(null,n,t),a=function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(n)};return r(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap)return;r(e=t)}else a()}}e.exports=function(e,t){(t=t||{}).singleton||"boolean"==typeof t.singleton||(t.singleton=(void 0===r&&(r=Boolean(window&&document&&document.all&&!window.atob)),r));var n=i(e=e||[],t);return function(e){if(e=e||[],"[object Array]"===Object.prototype.toString.call(e)){for(var r=0;r<n.length;r++){var a=o(n[r]);l[a].references--}for(var u=i(e,t),s=0;s<n.length;s++){var c=o(n[s]);0===l[c].references&&(l[c].updater(),l.splice(c,1))}n=u}}}}},t={};function n(r){var a=t[r];if(void 0!==a)return a.exports;var l=t[r]={id:r,exports:{}};return e[r](l,l.exports,n),l.exports}n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{"use strict";var e=n(294),t=n(935),r=n(490),a={pub:function(e){a.subs[e]||(a.subs[e]=[]),a.subs[e].forEach((function(e){return e()}))},sub:function(e,t){a.subs[e]||(a.subs[e]=[]),a.subs[e].push(t)},subs:{}};$(document).ready((function(){$("body").append($('<div id="cookie-consent"></div>')),t.render(e.createElement(r.Z,{dispatcher:a}),document.getElementById("cookie-consent"))})),window.plosCookieConsentBanner={reopen:function(){a.pub("open")}}})()})(); </script>  <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-content/plugins/plos-elementor-widgets/assets/js/widgets.js?ver=0.0.1" id="plos-elementor-js"></script> <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-content/plugins/plos-elementor-widgets/assets/lib/slick-1.8.1/slick/slick.js?ver=1.8.1" id="slick-js"></script> <script type="text/javascript" src="https://speakingofmedicine.plos.org/wp-content/themes/plos/dist/scripts/main_2eafddd7.js?ver=0.0.8" id="sage/main.js-js"></script>  <script> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='//static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('init','o5hg7'); twq('track','PageView'); </script>  </body> </html>

CINXE.COM

Speaking of Medicine and Health - The PLOS medical journals’ blog