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<!DOCTYPE html><html lang="en"><head><title data-react-helmet="true">Rohit Anand scite author profile</title> <meta data-react-helmet="true" name="viewport" content="width=device-width, initial-scale=1, maximum-scale=5, viewport-fit=cover"/><meta data-react-helmet="true" property="og:site_name" content="scite.ai"/><meta data-react-helmet="true" property="og:type" content="website"/><meta data-react-helmet="true" property="og:url" content="https://scite.ai"/><meta data-react-helmet="true" property="twitter:card" content="summary_large_image"/><meta data-react-helmet="true" name="twitter:site" content="@scite"/><meta data-react-helmet="true" property="title" content="Rohit Anand scite author profile"/><meta data-react-helmet="true" property="og:title" content="Rohit Anand scite author profile"/><meta data-react-helmet="true" property="twitter:title" content="Rohit Anand scite author profile"/><meta data-react-helmet="true" name="description" content="Supporting: 10 - Contrasting: 2 - Mentioning: 197 - Smart Citations for Rohit Anand"/><meta data-react-helmet="true" property="og:description" content="Supporting: 10 - Contrasting: 2 - Mentioning: 197 - Smart Citations for Rohit Anand"/><meta data-react-helmet="true" property="twitter:description" content="Supporting: 10 - Contrasting: 2 - Mentioning: 197 - Smart Citations for Rohit Anand"/><meta data-react-helmet="true" property="og:image" content="http://image.thum.io/get/ogImage/https://scite.ai/authors/rohit-anand-PQkgaR?bannerClosed=true&v=2"/><meta data-react-helmet="true" property="twitter:image" content="http://image.thum.io/get/ogImage/https://scite.ai/authors/rohit-anand-PQkgaR?bannerClosed=true&v=2"/> <link data-react-helmet="true" rel="preconnect" href="https://cdn.scite.ai" crossorigin="true"/><link data-react-helmet="true" rel="preconnect" href="https://fonts.googleapis.com"/><link data-react-helmet="true" rel="preconnect" href="https://fonts.gstatic.com" crossorigin="true"/><link 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transparent;width:64px;height:64px;margin:8px;border-width:8px"></div><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:64px;height:64px;margin:8px;border-width:8px"></div><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:64px;height:64px;margin:8px;border-width:8px"></div></div><div class="ProgressBar__bg___UVITD"><div class="ProgressBar__bar___AvWIq" style="width:0%"><div class="ProgressBar__inner___tiC7F ProgressBar__blue___VMO9o"></div></div></div></div><div style="opacity:0;pointer-events:none"><div class="PublicationInfo__articleCitationCountWrapper___fzJaN"><div class="PublicationInfo__countGroup___XGB7z"><span class="PublicationInfo__count___Dl63P">3</span><span class="PublicationInfo__countLabel___qOq41">Publications</span></div><div class="PublicationInfo__countGroup___XGB7z"><span class="PublicationInfo__count___Dl63P">209</span><span class="PublicationInfo__countLabel___qOq41">Citation Statements Received</span></div><div class="PublicationInfo__countGroup___XGB7z"><span class="PublicationInfo__count___Dl63P">173</span><span class="PublicationInfo__countLabel___qOq41">Citation Statements Given</span></div></div><div class="PublicationInfo__tallyWrapper___VYELt"><div class="PublicationInfo__profileTally___ZvSan"><span class="PublicationInfo__tallySubHeader___pW_2s">How they've been cited</span><a class="HorizontalTally__horizontalTally___gMrpx HorizontalTally__notClickable___L1uTA" disabled="" href="/"><div class="HorizontalTally__inner___AzKR8"><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--publications___MBaqU icon-publications"></i><span class="HorizontalTally__count___ZuxQA">292</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--supporting___ru3vm icon-supporting"></i><span class="HorizontalTally__count___ZuxQA">10</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--mentioning___zHr8j icon-mentioning"></i><span class="HorizontalTally__count___ZuxQA">197</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--contradicting___BpYwd icon-contradicting"></i><span class="HorizontalTally__count___ZuxQA">2</span></div></div></div></a></div><div class="PublicationInfo__profileTally___ZvSan"><span class="PublicationInfo__tallySubHeader___pW_2s">How they cite others</span><a class="HorizontalTally__horizontalTally___gMrpx HorizontalTally__notClickable___L1uTA" disabled="" href="/"><div class="HorizontalTally__inner___AzKR8"><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--publications___MBaqU icon-publications"></i><span class="HorizontalTally__count___ZuxQA">120</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--supporting___ru3vm icon-supporting"></i><span class="HorizontalTally__count___ZuxQA">21</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--mentioning___zHr8j icon-mentioning"></i><span class="HorizontalTally__count___ZuxQA">146</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--contradicting___BpYwd icon-contradicting"></i><span class="HorizontalTally__count___ZuxQA">6</span></div></div></div></a></div></div></div></div></div></div><div class="Author__profileDetails___YUiVp"><div class="Author__affiliationSection___Ud0ZU"><div><div><div class="Tooltip__reference___hgPSY"><span class="Author__detailsHeader___uq1SB">Affiliations <i class="Author__infoIcon___IhHWw fa fa-info-circle"></i></span></div></div><a class="Author__affiliation___svQn9 Link__link___plGt2 Link__blueLink___BhE5_ Author__affiliation___svQn9" tabindex="0" href="/affiliations/king-george-s-medical-university-ZxlJ">King George's Medical University</a>, <a class="Author__affiliation___svQn9 Link__link___plGt2 Link__blueLink___BhE5_ Author__affiliation___svQn9" tabindex="0" href="/affiliations/sinai-hospital-PvXb">Sinai Hospital</a>, <a class="Author__affiliation___svQn9 Link__link___plGt2 Link__blueLink___BhE5_ Author__affiliation___svQn9" tabindex="0" href="/affiliations/johns-hopkins-university-w8jy">Johns Hopkins University</a> </div></div><div class="Author__detailsContainer___rS4Du"><div class="Author__detailsHeader___uq1SB">Publications</div><div class="Author__setSort___wG8Ve"><style data-emotion="css 3iigni-container">.css-3iigni-container{pointer-events:none;position:relative;box-sizing:border-box;}</style><div class=" css-3iigni-container"><style data-emotion="css 7pg0cj-a11yText">.css-7pg0cj-a11yText{z-index:9999;border:0;clip:rect(1px, 1px, 1px, 1px);height:1px;width:1px;position:absolute;overflow:hidden;padding:0;white-space:nowrap;}</style><span id="react-select-358930-live-region" class="css-7pg0cj-a11yText"></span><span aria-live="polite" aria-atomic="false" aria-relevant="additions text" class="css-7pg0cj-a11yText"></span><style data-emotion="css 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hlgwow">.css-hlgwow{-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:grid;-webkit-flex:1;-ms-flex:1;flex:1;-webkit-box-flex-wrap:wrap;-webkit-flex-wrap:wrap;-ms-flex-wrap:wrap;flex-wrap:wrap;-webkit-overflow-scrolling:touch;position:relative;overflow:hidden;padding:2px 8px;box-sizing:border-box;}</style><div class=" css-hlgwow"><div style="label:singleValue;grid-area:1 / 1 / 2 / 3;max-width:100%;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;color:hsl(0, 0%, 60%);margin-left:2px;margin-right:2px;box-sizing:border-box">Order By: Most citations</div><style data-emotion="css 1mkvw8y">.css-1mkvw8y{visibility:hidden;-webkit-flex:1 1 auto;-ms-flex:1 1 auto;flex:1 1 auto;display:inline-grid;grid-area:1/1/2/3;grid-template-columns:0 min-content;margin:2px;padding-bottom:2px;padding-top:2px;color:hsl(0, 0%, 20%);box-sizing:border-box;}.css-1mkvw8y:after{content:attr(data-value) " 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0-1.615z"></path></svg></div></div></div></div></div></div><div class="Author__papers___ZUSjf"><div class="Author__paper___WaOSw Result__result___NPjx7"><div class="PaperCard__paperCard___Tkx_L"><div class="PaperCard__grid___NMQAD"><div class="PaperCard__abstractWrapper___Yq394"><div class="Paper__paper___CWi0y"><a class="Paper__title___WkJQP Link__link___plGt2 Link__bold___JGJNO Paper__title___WkJQP" tabindex="0" href="/reports/multidimensional-functional-and-structural-evaluation-aXvWvvx"><h3 class="Paper__title___WkJQP">Multidimensional Functional and Structural Evaluation Reveals Neuroretinal Impairment in Early Diabetic Retinopathy</h3></a><div class="Paper__referenceLine___quVTP"><div class="Authors__authors___uWMEz Paper__lineItem___FXrg7"><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/katherine-a-joltikov-38L6zZ"><span>Joltikov</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">1</a></sup></div><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/vivian-carla-de-castro-mvQdrn"><span>Castro</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">2</a></sup></div><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/jose-davila-wbwgWr"><span>D谩vila</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">3</a></sup></div><span> </span></div><span class="Authors__link___k07oy">et al.</span><span> 2017</span></div><span class="Paper__lineItem___FXrg7"><span class="Reference__reference___AIzFu"><span><a class="Link__link___plGt2 Link__underline___K1Y7j" tabindex="0" href="/journals/investigative-opthalmology-visual-science-mOeVe"><em>Invest. Ophthalmol. Vis. Sci.</em></a></span></span></span></div><div class="Paper__tallyLayout___k19c4"><a class="HorizontalTally__horizontalTally___gMrpx" href="/reports/multidimensional-functional-and-structural-evaluation-aXvWvvx"><div class="HorizontalTally__inner___AzKR8"><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--publications___MBaqU icon-publications"></i><span class="HorizontalTally__count___ZuxQA">84</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--supporting___ru3vm icon-supporting"></i><span class="HorizontalTally__count___ZuxQA">7</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--mentioning___zHr8j icon-mentioning"></i><span class="HorizontalTally__count___ZuxQA">78</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--contradicting___BpYwd icon-contradicting"></i><span class="HorizontalTally__count___ZuxQA">2</span></div></div></div></a></div><div class="Paper__linksLayout___Ql9Qd"><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" href="https://doi.org/10.1167/iovs.17-21863" tabindex="0" role="link" target="_blank" rel="noopener noreferrer nofollow">View full text</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Add to dashboard</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Cite</a></div></div><div aria-hidden="true" style="overflow:hidden;height:0;opacity:0"><div style="width:auto"><p class="Abstract__abstract___V8wNr PaperCard__abstract___lR5RS Paragraph__body____m5FY"><span><span>PurposeTo test whether quantitative functional tests and optical coherence tomography (OCT)-defined structure can serve as effective tools to diagnose and monitor early diabetic neuroretinal disease.MethodsFifty-seven subjects with diabetes (23 without diabetic retinopathy [no DR], 19 with mild nonproliferative diabetic retinopathy [mild NPDR], 15 with moderate to severe [moderate NPDR]), and 18 controls underwent full ophthalmic examination, fundus photography, spectral-domain optical coherence tomography (SD-OCT), e-ETDRS (Early Treatment Diabetic Retinopathy Study) acuity, and the quick contrast sensitivity function (qCSF) method. Perimetry testing included short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), frequency doubling perimetry (FDP), and rarebit perimetry (RBP).ResultsETDRS acuity and RBP were not sensitive for functional differences among subjects with diabetes. AULCSF, a metric of qCSF, was reduced in diabetics with moderate compared to mild NPDR (P = 0.03), and in subjects with no DR compared to controls (P = 0.04). SWAP and SAP mean deviation (MD) and foveal threshold (FT) were reduced in moderate compared to mild NPDR (SWAP, MD P = 0.002, FT P = 0.0006; SAP, MD P = 0.02, FT P = 0.007). FDP 10-2 showed reduced MD in moderate compared to mild NPDR (P = 0.02), and FDP 24-2 revealed reduced pattern standard deviation (PSD) in mild NPDR compared to no DR (P = 0.02). Structural analysis revealed thinning of the ganglion cell layer and inner plexiform layer (GCL+IPL) of moderate NPDR subjects compared to controls. The thinner GCL+IPL correlated with impaired retinal function.ConclusionsThis multimodal testing analysis reveals insights into disruption of the neuroretina in diabetes and may accelerate the testing of novel therapies.</span></span></p></div></div></div><div class="PaperCard__menu___wXkM0"><a class="PaperCard__textButton___ncs_Z" tabindex="0">show abstract</a><div class=""><i class="fa fa-2x fa-ellipsis-h DropdownMenu__dropdownMenuIcon___LGAcI"></i></div></div></div></div></div><div class="Author__paper___WaOSw Result__result___NPjx7"><div class="PaperCard__paperCard___Tkx_L"><div class="PaperCard__grid___NMQAD"><div class="PaperCard__abstractWrapper___Yq394"><div class="Paper__paper___CWi0y"><a class="Paper__title___WkJQP Link__link___plGt2 Link__bold___JGJNO Paper__title___WkJQP" tabindex="0" href="/reports/deep-learning-and-machine-learning-W85ZmD3d"><h3 class="Paper__title___WkJQP">Deep Learning and Machine Learning based Facial Emotion Detection using CNN</h3></a><div class="Paper__referenceLine___quVTP"><div class="Authors__authors___uWMEz Paper__lineItem___FXrg7"><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/shubham-kumar-singh-Ax1ROv"><span>Singh</span></a><sup class="Authors__affiliationSup___Vvflj">1</sup><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/revant-kumar-thakur-eKJpWr"><span>Thakur</span></a><sup class="Authors__affiliationSup___Vvflj">2</sup><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/satish-kumar-9p0d4"><span>Kumar</span></a><sup class="Authors__affiliationSup___Vvflj">3</sup><span> </span></div><span class="Authors__link___k07oy">et al.</span><span> 2022</span></div><span class="Paper__lineItem___FXrg7"><span class="Reference__reference___AIzFu"><span></span></span></span></div><div class="Paper__tallyLayout___k19c4"><a class="HorizontalTally__horizontalTally___gMrpx" href="/reports/deep-learning-and-machine-learning-W85ZmD3d"><div class="HorizontalTally__inner___AzKR8"><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--publications___MBaqU icon-publications"></i><span class="HorizontalTally__count___ZuxQA">132</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--supporting___ru3vm icon-supporting"></i><span class="HorizontalTally__count___ZuxQA">0</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--mentioning___zHr8j icon-mentioning"></i><span class="HorizontalTally__count___ZuxQA">68</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--contradicting___BpYwd icon-contradicting"></i><span class="HorizontalTally__count___ZuxQA">0</span></div></div></div></a></div><div class="Paper__linksLayout___Ql9Qd"><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" href="https://doi.org/10.23919/indiacom54597.2022.9763165" tabindex="0" role="link" target="_blank" rel="noopener noreferrer nofollow">View full text</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Add to dashboard</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Cite</a></div></div><div aria-hidden="true" style="overflow:hidden;height:0;opacity:0"><div style="width:auto"><p class="Abstract__abstract___V8wNr Abstract__noAbstract___b7A9r PaperCard__abstract___lR5RS Paragraph__body____m5FY">No abstract</p></div></div></div><div class="PaperCard__menu___wXkM0"><div class=""><i class="fa fa-2x fa-ellipsis-h DropdownMenu__dropdownMenuIcon___LGAcI"></i></div></div></div></div></div><div class="Author__paper___WaOSw Result__result___NPjx7"><div class="PaperCard__paperCard___Tkx_L"><div class="PaperCard__grid___NMQAD"><div class="PaperCard__abstractWrapper___Yq394"><div class="Paper__paper___CWi0y"><a class="Paper__title___WkJQP Link__link___plGt2 Link__bold___JGJNO Paper__title___WkJQP" tabindex="0" href="/reports/disorganization-of-retinal-inner-layers-zRNknVE"><h3 class="Paper__title___WkJQP">Disorganization of Retinal Inner Layers (DRIL) and Neuroretinal Dysfunction in Early Diabetic Retinopathy</h3></a><div class="Paper__referenceLine___quVTP"><div class="Authors__authors___uWMEz Paper__lineItem___FXrg7"><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/katherine-a-joltikov-38L6zZ"><span>Joltikov</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">1</a></sup></div><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/christopher-sesi-Zvd9y"><span>Sesi</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">2</a></sup></div><span>, </span></div><div class="Authors__author___TTnHS"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/authors/vivian-carla-de-castro-mvQdrn"><span>Castro</span></a><div class="Tooltip__reference___hgPSY"><sup class="Authors__affiliationSup___Vvflj"><a class="Link__link___plGt2 Link__blueLink___BhE5_" tabindex="0" href="/affiliations/visual-sciences-united-states-5YmNQ">3</a></sup></div><span> </span></div><span class="Authors__link___k07oy">et al.</span><span> 2018</span></div><span class="Paper__lineItem___FXrg7"><span class="Reference__reference___AIzFu"><span><a class="Link__link___plGt2 Link__underline___K1Y7j" tabindex="0" href="/journals/investigative-opthalmology-visual-science-mOeVe"><em>Invest. Ophthalmol. Vis. Sci.</em></a></span></span></span></div><div class="Paper__tallyLayout___k19c4"><a class="HorizontalTally__horizontalTally___gMrpx" href="/reports/disorganization-of-retinal-inner-layers-zRNknVE"><div class="HorizontalTally__inner___AzKR8"><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--publications___MBaqU icon-publications"></i><span class="HorizontalTally__count___ZuxQA">76</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--supporting___ru3vm icon-supporting"></i><span class="HorizontalTally__count___ZuxQA">3</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--mentioning___zHr8j icon-mentioning"></i><span class="HorizontalTally__count___ZuxQA">51</span></div></div><div class="HorizontalTally__column___d6ltY"><div class="Tooltip__reference___hgPSY"><i class="undefined TypeIcon__typeIcon___USGCh icon TypeIcon__typeIcon--contradicting___BpYwd icon-contradicting"></i><span class="HorizontalTally__count___ZuxQA">0</span></div></div></div></a></div><div class="Paper__linksLayout___Ql9Qd"><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" href="https://doi.org/10.1167/iovs.18-24955" tabindex="0" role="link" target="_blank" rel="noopener noreferrer nofollow">View full text</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Add to dashboard</a><a class="Paper__link___YsYPi Link__link___plGt2 Link__blueLink___BhE5_ Link__underline___K1Y7j Paper__link___YsYPi" tabindex="0" role="button">Cite</a></div></div><div aria-hidden="true" style="overflow:hidden;height:0;opacity:0"><div style="width:auto"><p class="Abstract__abstract___V8wNr PaperCard__abstract___lR5RS Paragraph__body____m5FY"><span><span>PurposeTo elucidate the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME).MethodsFifty-seven participants with diabetes mellitus (DM) and 18 healthy controls underwent comprehensive ophthalmic examination, fundus photography, and spectral-domain optical coherence tomography. Scans of the fovea were evaluated for the presence of DRIL. Retinal function was evaluated using Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, the quick contrast sensitivity function (qCSF) on the AST Sentio Platform, short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), and frequency doubling perimetry (FDP). ANOVA and Kruskal-Wallis were used to compare retinal function in subjects with and without DRIL. Tukey-Kramer test and Wilcoxon were used for post hoc analysis.ResultsDRIL was identified in 9 of 57 diabetic subjects. DRIL subjects had higher body mass index and longer diabetes duration compared to diabetic subjects without DRIL (P = 0.03 and P = 0.009, respectively). Subjects with DRIL had reduced ETDRS visual acuity (P = 0.003), contrast sensitivity function (P = 0.0003), and SAP performance (PSD, P < 0.0001) compared to controls and diabetic subjects without DRIL. Structural analysis revealed inner retinal thinning, and some outer retinal thinning, associated with DRIL.ConclusionsDiabetic subjects with DRIL have reduced retinal function compared to those without DRIL, and defective retinal lamination may be an early cellular consequence of diabetes responsible for this in some patients. Following further longitudinal studies, DRIL may be a readily available and reliable structural biomarker for reduced retinal function in early diabetic neuroretinal disease.</span></span></p></div></div></div><div class="PaperCard__menu___wXkM0"><a class="PaperCard__textButton___ncs_Z" tabindex="0">show abstract</a><div class=""><i class="fa fa-2x fa-ellipsis-h DropdownMenu__dropdownMenuIcon___LGAcI"></i></div></div></div></div></div><div class="Author__paginatorLayout___ZeycX"><div class="Author__paginatorLoading___Zgmtf layouts__absoluteCenter___zke7Q" style="opacity:0;pointer-events:auto"><div data-testid="circle-spinner" class="CircleSpinner__sciteLoadingRing___nlTrH" style="width:64px;height:64px"><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:51.2px;height:51.2px;margin:6.4px;border-width:6.4px"></div><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:51.2px;height:51.2px;margin:6.4px;border-width:6.4px"></div><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:51.2px;height:51.2px;margin:6.4px;border-width:6.4px"></div><div class="CircleSpinner__ringComponent____iKPi" style="border-color:#0062ff transparent transparent transparent;width:51.2px;height:51.2px;margin:6.4px;border-width:6.4px"></div></div></div></div></div></div></div></div></div></div><div class="Footer__layout___jrAhC"><div class="Footer__mainLayout___MVOfi"><div class="Footer__aboutContainer___TwE0S"><img width="128px" height="41px" alt="scite logo" src="https://cdn.scite.ai/assets/images/logo.svg"/><p class="Paragraph__body____m5FY">scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations鈥揷itations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.</p><div class="Footer__contact___DGc_M"><h6 class="Header__h6___QzBvp">Contact Info</h6><div><p class="Footer__address___VMUTY Paragraph__body____m5FY">customersupport@researchsolutions.com</p><p class="Footer__address___VMUTY Paragraph__body____m5FY">10624 S. 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Perimetry testing included short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), frequency doubling perimetry (FDP), and rarebit perimetry (RBP).ResultsETDRS acuity and RBP were not sensitive for functional differences among subjects with diabetes. AULCSF, a metric of qCSF, was reduced in diabetics with moderate compared to mild NPDR (P = 0.03), and in subjects with no DR compared to controls (P = 0.04). SWAP and SAP mean deviation (MD) and foveal threshold (FT) were reduced in moderate compared to mild NPDR (SWAP, MD P = 0.002, FT P = 0.0006; SAP, MD P = 0.02, FT P = 0.007). FDP 10-2 showed reduced MD in moderate compared to mild NPDR (P = 0.02), and FDP 24-2 revealed reduced pattern standard deviation (PSD) in mild NPDR compared to no DR (P = 0.02). Structural analysis revealed thinning of the ganglion cell layer and inner plexiform layer (GCL+IPL) of moderate NPDR subjects compared to controls. The thinner GCL+IPL correlated with impaired retinal function.ConclusionsThis multimodal testing analysis reveals insights into disruption of the neuroretina in diabetes and may accelerate the testing of novel therapies.","authors":[{"family":"Joltikov","given":"Katherine A.","affiliation":"Visual Sciences (United States)","authorSlug":"katherine-a-joltikov-38L6zZ","authorName":"Katherine A. Joltikov","authorID":"9345388","authorLastKnownAffiliationId":202325,"authorSequenceNumber":1,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Castro","given":"Vivian Carla de","affiliation":"Visual Sciences (United States)","authorSlug":"vivian-carla-de-castro-mvQdrn","authorName":"Vivian Carla de Castro","authorID":"9226243","authorLastKnownAffiliationId":205104,"authorSequenceNumber":2,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"D谩vila","given":"Jos茅","affiliation":"Visual Sciences (United States)","authorSlug":"jose-davila-wbwgWr","authorName":"Jos茅 D谩vila","authorID":"8384228","authorLastKnownAffiliationId":7050,"authorSequenceNumber":3,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Anand","given":"Rohit","affiliation":"Visual Sciences (United States)","authorSlug":"rohit-anand-PQkgaR","authorName":"Rohit Anand","authorID":"7258445","authorLastKnownAffiliationId":4831,"authorSequenceNumber":4,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Khan","given":"Sami M.","affiliation":"Visual Sciences (United States)","authorSlug":"sami-m-khan-ANMedZ","authorName":"Sami M. Khan","authorID":"9172249","authorLastKnownAffiliationId":158401,"authorSequenceNumber":5,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Farbman","given":"Neil","affiliation":"Visual Sciences (United States)","authorSlug":"neil-farbman-ayKvxr","authorName":"Neil Farbman","authorID":"9478639","authorLastKnownAffiliationId":20180,"authorSequenceNumber":6,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Jackson","given":"Gregory R.","authorSlug":"gregory-r-jackson-YZYbA2","authorName":"Gregory R. Jackson","authorID":"4626351","authorLastKnownAffiliationId":174394,"authorSequenceNumber":7},{"family":"Johnson","given":"Chris A.","affiliation":"Visual Sciences (United States)","authorSlug":"chris-a-johnson-68En4p","authorName":"Chris A. Johnson","authorID":"4947254","authorLastKnownAffiliationId":16569,"authorSequenceNumber":8,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Gardner","given":"Thomas W.","affiliation":"Visual Sciences (United States)","authorSlug":"thomas-w-gardner-8GJkP3","authorName":"Thomas W. Gardner","authorID":"5010321","authorLastKnownAffiliationId":205237,"authorSequenceNumber":9,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"}],"keywords":["Special Issue"],"year":2017,"shortJournal":"Invest. Ophthalmol. Vis. Sci.","publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","volume":"58","page":"BIO277","retracted":false,"memberId":27,"issns":["1552-5783"],"tally":{"total":89,"supporting":7,"contradicting":2,"mentioning":78,"unclassified":2,"doi":"10.1167\u002Fiovs.17-21863","citingPublications":84},"citingTally":{"total":124,"supporting":16,"contradicting":6,"mentioning":102,"unclassified":0,"sourceDoi":"10.1167\u002Fiovs.17-21863","numCitedPublications":73},"editorialNotices":[],"journalSlug":"investigative-opthalmology-visual-science-mOeVe","preprintLinks":[],"publicationLinks":[],"normalizedTypes":["article"]},{"id":245660994,"doi":"10.1167\u002Fiovs.18-24955","slug":"disorganization-of-retinal-inner-layers-zRNknVE","type":"journal-article","title":"Disorganization of Retinal Inner Layers (DRIL) and Neuroretinal Dysfunction in Early Diabetic Retinopathy","abstract":"PurposeTo elucidate the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME).MethodsFifty-seven participants with diabetes mellitus (DM) and 18 healthy controls underwent comprehensive ophthalmic examination, fundus photography, and spectral-domain optical coherence tomography. Scans of the fovea were evaluated for the presence of DRIL. Retinal function was evaluated using Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, the quick contrast sensitivity function (qCSF) on the AST Sentio Platform, short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), and frequency doubling perimetry (FDP). ANOVA and Kruskal-Wallis were used to compare retinal function in subjects with and without DRIL. Tukey-Kramer test and Wilcoxon were used for post hoc analysis.ResultsDRIL was identified in 9 of 57 diabetic subjects. DRIL subjects had higher body mass index and longer diabetes duration compared to diabetic subjects without DRIL (P = 0.03 and P = 0.009, respectively). Subjects with DRIL had reduced ETDRS visual acuity (P = 0.003), contrast sensitivity function (P = 0.0003), and SAP performance (PSD, P \u003C 0.0001) compared to controls and diabetic subjects without DRIL. Structural analysis revealed inner retinal thinning, and some outer retinal thinning, associated with DRIL.ConclusionsDiabetic subjects with DRIL have reduced retinal function compared to those without DRIL, and defective retinal lamination may be an early cellular consequence of diabetes responsible for this in some patients. Following further longitudinal studies, DRIL may be a readily available and reliable structural biomarker for reduced retinal function in early diabetic neuroretinal disease.","authors":[{"family":"Joltikov","given":"Katherine A.","affiliation":"Visual Sciences (United States)","authorSlug":"katherine-a-joltikov-38L6zZ","authorName":"Katherine A. Joltikov","authorID":"9345388","authorLastKnownAffiliationId":202325,"authorSequenceNumber":1,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Sesi","given":"Christopher","affiliation":"Visual Sciences (United States)","authorSlug":"christopher-sesi-Zvd9y","authorName":"Christopher Sesi","authorID":"2871575","authorLastKnownAffiliationId":5792,"authorSequenceNumber":2,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Castro","given":"Vivian Carla de","affiliation":"Visual Sciences (United States)","authorSlug":"vivian-carla-de-castro-mvQdrn","authorName":"Vivian Carla de Castro","authorID":"9226243","authorLastKnownAffiliationId":205104,"authorSequenceNumber":3,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"D谩vila","given":"Jos茅","affiliation":"Visual Sciences (United States)","authorSlug":"jose-davila-wbwgWr","authorName":"Jos茅 D谩vila","authorID":"8384228","authorLastKnownAffiliationId":7050,"authorSequenceNumber":4,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Anand","given":"Rohit","affiliation":"Visual Sciences (United States)","authorSlug":"rohit-anand-PQkgaR","authorName":"Rohit Anand","authorID":"7258445","authorLastKnownAffiliationId":4831,"authorSequenceNumber":5,"affiliationSlug":"visual-sciences-united-states-5YmNQ","affiliationID":"202325"},{"family":"Khan","given":"Sami M.","affiliation":"Visual Sciences (United States)","authorSlug":"sami-m-khan-ANMedZ","authorName":"Sami M. 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