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class="breadcrumb-text">Extrakorporale Photopherese</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"></div><div class="section section-default"><div id="c74589" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-right imageorient-25"><div class="textpic-item textpic-gallery"><div class="gallery-row"><div class="gallery-item gallery-item-size-1"><div class="image-wrap image-wrap-lightbox"><figure class="image"><div class="position-relative"><a href="https://www.transfusionsmedizin.uk-erlangen.de/fileadmin/_processed_/4/b/csm_Schema_ECP_9ea5a02c73.jpg" data-pswp-width="1200" data-pswp-height="865" target="_blank" class="lightbox" title="" ><picture class=""><source data-variant="default" data-maxwidth="765" media="(min-width: 1600px)" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_cfe149fffa.jpg 1x"><source data-variant="xlarge" data-maxwidth="595" media="(min-width: 1400px)" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_403aef1698.jpg 1x"><source data-variant="large" data-maxwidth="595" media="(min-width: 1260px)" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_403aef1698.jpg 1x"><source data-variant="medium" data-maxwidth="477" media="(min-width: 1024px)" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_42d81c14d5.jpg 1x"><source data-variant="small" data-maxwidth="690" media="(min-width: 720px)" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_0adf059436.jpg 1x"><source data-variant="extrasmall" data-maxwidth="690" srcset="/fileadmin/_processed_/4/b/csm_Schema_ECP_0adf059436.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/4/b/csm_Schema_ECP_be98f22256.jpg" width="765" height="552" title="" alt=""></picture></a></div><figcaption class="caption">Schematische Darstellung des Ablaufs einer ECP-Behandlung</figcaption></figure></div></div></div></div><div class="textpic-item textpic-text"><div class="frame-header"><h2 class="element-header "><span>Extrakorporale Photopherese</span></h2></div><p>Die Extrakorporale Photopherese (ECP) ist eine nebenwirkungsarme zellbasierte Immuntherapie, die bei der Behandlung des kutanen T-Zelllymphoms (CTCL), der Organtransplantatabsto脽ungsreaktion oder der Graft-versus-Host Erkrankung (GVHD) infolge einer Knochenmarkstransplantation Anwendung findet. Dabei werden aus dem Blut der Patienten mittels eines Aphareseverfahrens Immunzellen angereichert. Diese werden au脽erhalb des K枚rpers mit einer photosensibilisierenden Substanz, dem 8-Methoxypsoralen (8-MOP), versetzt und mit UVA-Licht bestrahlt. Direkt im Anschluss an diese Prozedur werden alle Zellen und Blutbestandteile in den K枚rper zur眉ckfundiert. Die Bestrahlung l枚st in den behandelten Zellen zytotoxische Effekte aus. Dar眉ber hinaus wirken die bestrahlten Zellen immunmodulatorisch auf das nicht-behandelte Immunsystem.</p></div></div></div></div></div></div></div><div id="c74590" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-above"><div class="textpic-item textpic-gallery"></div><div class="textpic-item textpic-text"><p>Ein Alleinstellungsmerkmal der ECP ist dabei, dass, je nachdem zur Behandlung welchen Krankheitsbildes sie eingesetzt wird, gegens盲tzliche immunmodulatorische Wirkungen erzielt werden. Bei der Behandlung einer GVHD oder einer Transplantatabsto脽ung bewirkt die ECP die Induktion einer tolerogenen Immunantwort, w盲hrend sie bei der Behandlung eines CTCL eine anti-Tumor Immunantwort induziert. Ein weiterer Vorteil der ECP ist, dass die Immunmodulation -im Gegensatz zu anderen immunsuppressiven Therapien- Antigen-spezifisch ist und somit eine Immunantwort gegen眉ber Pathogenen nicht kompromittiert wird. Obwohl das Verfahren aufgrund dieser Eigenschaften und Vorteile schon seit Jahrzehnten erfolgreich eingesetzt wird, ist der ihr zugrundeliegende immunologische Wirkmechanismus immer noch nicht vollst盲ndig verstanden und aufgekl盲rt.</p></div></div></div></div></div></div></div><div id="c74778" class=" frame frame-default frame-type-textpic frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="textpic textpic-left imageorient-26"><div class="textpic-item textpic-gallery"><div class="gallery-row"><div class="gallery-item gallery-item-size-1"><div class="image-wrap image-wrap-lightbox"><figure class="image"><div class="position-relative"><a href="https://www.transfusionsmedizin.uk-erlangen.de/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_2462c039e6.jpg" data-pswp-width="1200" data-pswp-height="800" target="_blank" class="lightbox" title="" ><picture class=""><source data-variant="default" data-maxwidth="765" media="(min-width: 1600px)" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_8874d05108.jpg 1x"><source data-variant="xlarge" data-maxwidth="595" media="(min-width: 1400px)" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_b0c72bf1e1.jpg 1x"><source data-variant="large" data-maxwidth="595" media="(min-width: 1260px)" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_b0c72bf1e1.jpg 1x"><source data-variant="medium" data-maxwidth="477" media="(min-width: 1024px)" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_6db03ff8d6.jpg 1x"><source data-variant="small" data-maxwidth="690" media="(min-width: 720px)" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_0993454989.jpg 1x"><source data-variant="extrasmall" data-maxwidth="690" srcset="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_0993454989.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/8/3/csm_Bestrahlungskammer_28a8f63d5f.jpg" width="765" height="510" title="" alt=""></picture></a></div><figcaption class="caption">Bestrahlung von Zellen im Labor mit UVA-Licht<br /></figcaption></figure></div></div></div></div><div class="textpic-item textpic-text"><p>Ziel unserer Forschung ist es deshalb, verschiedene Aspekte der immunologischen Wirkung der ECP n盲her zu untersuchen, um den Wirkmechanismus besser verstehen zu k枚nnen und so das bestehende Therapieverfahren weiter optimieren und vielleicht sogar neue Anwendungsm枚glichkeiten der ECP er枚ffnen zu k枚nnen.</p></div></div></div></div></div></div></div><div id="c74591" class=" frame frame-default frame-type-list frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Ansprechpartner</span></h3></div><div class="result-list-items contact-items result-list-items-glossar columnsCount2"><div class="result-list-item"><div class="list-item-text"><div class="category-flag-wrapper"><div class="category-flag"><a title="脰ffnet die Webseite von Transfusionsmedizin" target="_blank" href="/">Transfusionsmedizin</a></div></div><h4><a title="脰ffnet die Visitenkarte von Dr. rer. nat. 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