CINXE.COM

<!DOCTYPE html> <html lang="ko"> <head> <title>OASIS Repository@POSTECHLIBRARY: GENOME-WIDE ANALYSIS OF HISTONE METHYLATION REVEALS CHROMATIN STATE-BASED REGULATION OF GENE TRANSCRIPTION AND FUNCTION OF MEMORY CD8(+) T CELLS</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="Generator" content="DSpace 5.5" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="description" content="Postech OASIS Repository" /> <meta name="keywords" content="오아시스,레포지토리,리포지터리,저장소,포스텍,박태준학술정보관,포항공과대학교,포항공대,POSTECH,Pohang University of Science and Technology,도서관,IR,연구업적,학술실적,연구성과,dspace" /> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon"/> <link rel="search" type="application/opensearchdescription+xml" href="/open-search/description.xml" title="DSpace" /> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <link rel="schema.OAK" href="http://www.oak.go.kr/terms/" /> <meta name="OAK.author" content="Araki, Y" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Wang, ZB" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Zang, CZ" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Wood, WH" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Schones, D" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Cui, KR" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Roh, TY" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Lhotsky, B" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Wersto, RP" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Peng, WQ" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Becker, KG" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Zhao, K" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Weng, NP" scheme="OAK.AUTHOR" /> <meta name="DCTERMS.dateAccepted" content="2016-04-01T08:33:22Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2016-04-01T08:33:22Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.created" content="2009-08-25" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2009-06" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.identifier.issn" content="1074-7613" scheme="OAK.ISSN" /> <meta name="DC.identifier" content="2009-OAK-0000018468" /> <meta name="DC.identifier" content="https://oasis.postech.ac.kr/handle/2014.oak/28240" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3) and gene expression profiles in naive and memory CD8(+) T cells. We found that specific correlation exists between gene expression and the amounts of H3K4me3 (positive correlation) and H3K27me3 (negative correlation) across the gene body. These correlations displayed four distinct modes (repressive, active, poised, and bivalent), reflecting different functions of these genes in CD8(+) T cells. Furthermore, a permissive chromatin state of each gene was established by a combination of different histone modifications. Our findings reveal a complex regulation by histone methylation in differential gene expression and suggest that histone methylation may be responsible for memory CD8(+) T cell function." /> <meta name="DC.description" content="X" /> <meta name="DC.language" content="English" /> <meta name="DC.publisher" content="CELL PRESS" /> <meta name="DC.relation" content="IMMUNITY" /> <meta name="DC.title" content="GENOME-WIDE ANALYSIS OF HISTONE METHYLATION REVEALS CHROMATIN STATE-BASED REGULATION OF GENE TRANSCRIPTION AND FUNCTION OF MEMORY CD8(+) T CELLS" /> <meta name="DC.type" content="Article" /> <meta name="DC.contributor" content="생명과학과" /> <meta name="DC.identifier" content="10.1016/j.immuni.2009.05.006" /> <meta name="DC.relation" content="30" /> <meta name="DC.relation" content="6" /> <meta name="DC.relation" content="912" /> <meta name="DC.relation" content="925" /> <meta name="DC.contributor" content="10138348" /> <meta name="DC.relation" content="IMMUNITY" /> <meta name="DC.relation" content="SCI급, SCOPUS 등재논문" /> <meta name="DC.relation" content="SCI" /> <meta name="DC.identifier" content="9928" /> <meta name="DC.type" content="ART" /> <meta name="DC.identifier" content="IMMUNITY, v.30, no.6, pp.912 - 925" /> <meta name="DC.identifier" content="000267270700017" /> <meta name="DC.date" content="2019-02-01" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.relation.page" content="925" scheme="OAK.PAGE" /> <meta name="OAK.relation.issue" content="6" scheme="OAK.ISSUE" /> <meta name="OAK.relation.page" content="912" scheme="OAK.PAGE" /> <meta name="OAK.relation.journal" content="IMMUNITY" scheme="OAK.JOURNAL" /> <meta name="OAK.relation.volume" content="30" scheme="OAK.VOLUME" /> <meta name="DC.contributor" content="Roh, TY" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="147" /> <meta name="DC.description" content="N" /> <meta name="DC.type" content="Article" /> <meta name="DC.subject" content="IFN-GAMMA LOCI" /> <meta name="DC.subject" content="CUTTING EDGE" /> <meta name="DC.subject" content="EXPRESSION" /> <meta name="DC.subject" content="EFFECTOR" /> <meta name="DC.subject" content="ACETYLATION" /> <meta name="DC.subject" content="PROTEIN" /> <meta name="DC.subject" content="DIFFERENTIATION" /> <meta name="DC.subject" content="EOMESODERMIN" /> <meta name="DC.subject" content="RECRUITMENT" /> <meta name="DC.subject" content="HOMEOSTASIS" /> <meta name="DC.relation" content="Immunology" /> <meta name="DC.description" content="scie" /> <meta name="DC.description" content="scopus" /> <meta name="citation_keywords" content="Article" /> <meta name="citation_title" content="GENOME-WIDE ANALYSIS OF HISTONE METHYLATION REVEALS CHROMATIN STATE-BASED REGULATION OF GENE TRANSCRIPTION AND FUNCTION OF MEMORY CD8(+) T CELLS" /> <meta name="citation_issn" content="1074-7613" /> <meta name="citation_publisher" content="CELL PRESS" /> <meta name="citation_author" content="Araki, Y" /> <meta name="citation_author" content="Wang, ZB" /> <meta name="citation_author" content="Zang, CZ" /> <meta name="citation_author" content="Wood, WH" /> <meta name="citation_author" content="Schones, D" /> <meta name="citation_author" content="Cui, KR" /> <meta name="citation_author" content="Roh, TY" /> <meta name="citation_author" content="Lhotsky, B" /> <meta name="citation_author" content="Wersto, RP" /> <meta name="citation_author" content="Peng, WQ" /> <meta name="citation_author" content="Becker, KG" /> <meta name="citation_author" content="Zhao, K" /> <meta name="citation_author" content="Weng, NP" /> <meta name="citation_date" content="2009-06" /> <meta name="citation_abstract_html_url" content="https://oasis.postech.ac.kr/handle/2014.oak/28240" /> <link rel="stylesheet" href="/css/bootstrap.min.css" defer /> <link rel="stylesheet" href="/css/layout.css" async /> <link rel="stylesheet" href="/css/mquery.css" defer /> <link rel="stylesheet" href="/css/slidebars.css" defer />  <link rel="stylesheet" href="/css/owl.carousel.css" defer />  <link rel="stylesheet" href="/css/owl.theme.css" defer /> <link rel="stylesheet" href="/css/bootstrap-partof.css" defer /> <script src="/js/jquery-1.9.1.min.js"></script> <script src="/js/jquery-ui.js"></script> <script src="/js/bootstrap.min.js"></script> <script src="/js/owl.carousel.min.js"></script> <script src="/js/common.js" defer></script> <script src="/utils.js" defer></script> <script src="/static/js/holder.js" defer></script> <script src="/static/js/choice-support.js" defer></script> <script src="/js/ms-clarity.js"></script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-B9EHYYGM78"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-B9EHYYGM78'); </script>   </head> <body> <div id="sb-site"> <script> function doSearch () { (function($) { if ($("select[name='filtername']").val() != '') { if ($("input:text[name='query']").val() == '') { $("input:text[name='contains']").val(""); $("select[name='filtername']").attr("disabled", true); $("input:hidden[name='filtertype']").attr("disabled", true); $("input:hidden[name='filterquery']").attr("disabled", true); } else { $("input:hidden[name='filterquery']").val($("input:text[name='query']").val()); $("input:text[name='query']").val(""); } } else { $("input:text[name='contains']").val(""); $("select[name='filtername']").attr("disabled", true); $("input:hidden[name='filtertype']").attr("disabled", true); $("input:hidden[name='filterquery']").attr("disabled", true); } })(jQuery.noConflict()); } </script> <div class="col_width sub_header"> <h1><a href="/">Open Access System for Information Sharing</a></h1> <form action="/simple-search" method="get" onsubmit="doSearch();"> <input type="hidden" name="filtertype" value="contains" /> <div class="sub_search_box"> <span class="ss_select"> <select name="filtername" id="header_filter"> <option value="">All</option> <option value="title">Title</option> <option value="author">Author</option> <option value="subject">Subject</option> </select> </span> <div class="ss_int_box"> <input type="text" title="검색창" class="ms_int" name="query" placeholder="Enter Search keyword"/> <input type="hidden" name="filterquery"/> <input type="submit" title="검색" class="ms_bt" value="search" /> </div> </div> </form> <div class="gnav"> <a href="/password-login" class="first_a">Login</a> <a href="http://library.postech.ac.kr/" target="_blank">Library</a> <script type="text/javascript">  </script><noscript><a href="/help/index.html#" target="dspacepopup">Help</a></noscript></div> <div class="tablet_nav sb-toggle-right"> <a href="#" class="tablet_nav_bt" id="mnav_bt"> <span class="line"></span> <span class="line"></span> <span class="line"></span> </a> </div> <div class="mobile_search"> <form action="/simple-search" method="get" id="search_form"> <a href="javascript:doSearch($('#search_form'));" class="mobile_sbt">검색</a> <div class="mobile_s_inner"> <span class="d_arrow"></span> <p class="mmobile_s_int"><input type="text" title="검색" placeholder="Search"></p> </div> </form> </div> </div>  <div class="sub_nav_wrap"> <div class="col_width"> <div class="sub_nav_box"> <ul> <li class="home_nav"><a href="/" >HOME</a></li> <li><a href="/community-list" >Communities & Collections</a></li> <li><a href="/browse-researcher" >Researchers</a></li> <li><a href="/browse?type=title" class='on'>Title</a></li> </ul> </div> <div class="page_nav"> <a href="/" class="page_home"><strong> </strong></a> <a href="/handle/2014.oak/398" style="max-width: 170px;"><strong>General Graduate School of Life Science (일반대학원 생명과학과)</strong></a> <a href="/handle/2014.oak/399" ><strong>1. Journal Papers</strong></a> </div></div> </div> <div class="col_width sub_container add_widget"> <div class="sub_contents"> <script src="https://apis.google.com/js/platform.js" async defer></script> <script type="text/javascript"> // google plus api window.___gcfg = {lang: 'ko'}; (function() { var po = document.createElement('script'); po.type = 'text/javascript'; po.async = true; po.src = 'https://apis.google.com/js/platform.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(po, s); })(); </script> <div class="sub_title"> <h3> </h3> <div class="type_icon"> <span class="article_type">Article</span> </div> </div> <div class="view_top_box"> <div class="view_bt_box"> <span class="cited_span science_span">Cited <em>230</em> time in <img src="/image/common/webofscience.png" alt="webofscience"></span> <span class="cited_span">Cited <em>0</em> time in <img src="/image/common/scopus.png" alt="scopus"></span> </div> <div class="view_bt_area"> <span>Metadata Downloads</span> <form action="/export" method="post"> <input type="hidden" name="item_id" value="27940"/> <div class="view_downbt"> <ul> <li> <input type="submit" name="submit_export_dc" value="DC(XML)"/> </li> <li> <input type="submit" name="submit_export_excel" value="EXCEL"/> </li> </ul> </div> </form> </div> </div> <div class="view_contents"> <p class="view_title">GENOME-WIDE ANALYSIS OF HISTONE METHYLATION REVEALS CHROMATIN STATE-BASED REGULATION OF GENE TRANSCRIPTION AND FUNCTION OF MEMORY CD8(+) T CELLS <em class="a_l_ink a_l_scie">SCIE</em> <em class="a_l_ink a_l_scopus">SCOPUS</em> </p> <div class="view_inner_con"> <dl><dt>Title</dt><dd>GENOME-WIDE ANALYSIS OF HISTONE METHYLATION REVEALS CHROMATIN STATE-BASED REGULATION OF GENE TRANSCRIPTION AND FUNCTION OF MEMORY CD8(+) T CELLS</dd></dl> <dl><dt>Authors</dt><dd><a class="author"href="/browse?type=author&value=Araki%2C+Y">Araki, Y</a>; <a class="author"href="/browse?type=author&value=Wang%2C+ZB">Wang, ZB</a>; <a class="author"href="/browse?type=author&value=Zang%2C+CZ">Zang, CZ</a>; <a class="author"href="/browse?type=author&value=Wood%2C+WH">Wood, WH</a>; <a class="author"href="/browse?type=author&value=Schones%2C+D">Schones, D</a>; <a class="author"href="/browse?type=author&value=Cui%2C+KR">Cui, KR</a>; <a class="author_a" href="/researcher-profile?ep=419">Roh, TY</a>; <a class="author"href="/browse?type=author&value=Lhotsky%2C+B">Lhotsky, B</a>; <a class="author"href="/browse?type=author&value=Wersto%2C+RP">Wersto, RP</a>; <a class="author"href="/browse?type=author&value=Peng%2C+WQ">Peng, WQ</a>; <a class="author"href="/browse?type=author&value=Becker%2C+KG">Becker, KG</a>; <a class="author"href="/browse?type=author&value=Zhao%2C+K">Zhao, K</a>; <a class="author"href="/browse?type=author&value=Weng%2C+NP">Weng, NP</a></dd></dl> <dl><dt>Date Issued</dt><dd>2009-06 </dd></dl> <dl><dt>Publisher</dt><dd>CELL PRESS</dd></dl> <dl><dt>Abstract</dt><dd>Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3) and gene expression profiles in naive and memory CD8(+) T cells. We found that specific correlation exists between gene expression and the amounts of H3K4me3 (positive correlation) and H3K27me3 (negative correlation) across the gene body. These correlations displayed four distinct modes (repressive, active, poised, and bivalent), reflecting different functions of these genes in CD8(+) T cells. Furthermore, a permissive chromatin state of each gene was established by a combination of different histone modifications. Our findings reveal a complex regulation by histone methylation in differential gene expression and suggest that histone methylation may be responsible for memory CD8(+) T cell function.</dd></dl> <dl><dt>URI</dt><dd><a href="https://oasis.postech.ac.kr/handle/2014.oak/28240" class="link_type">https://oasis.postech.ac.kr/handle/2014.oak/28240</a></dd></dl> <dl><dt>DOI</dt><dd><a href="http://dx.doi.org/10.1016/j.immuni.2009.05.006">10.1016/j.immuni.2009.05.006</a></dd></dl> <dl><dt>ISSN</dt><dd>1074-7613</dd></dl> <dl><dt>Article Type</dt><dd>Article</dd></dl> <dl><dt>Citation</dt><dd>IMMUNITY, vol. 30, no. 6, page. 912 - 925, 2009-06</dd></dl> <dl class="file_item_dl"><dt>Files in This Item:</dt> <dd class="file_download">There are no files associated with this item.</dd> </dl> </div> <div class="record_bt_box"> <a href="/handle/2014.oak/28240?mode=full">Show full item record</a> </div> <div class="al_right"> </div> <div class="sns_wrap"> <div class="sns_box"> <p class="qr_box"><img src="https://api.qrserver.com/v1/create-qr-code/?size=66x66&data=https://oasis.postech.ac.kr/handle/2014.oak/28240" alt="qr_code"></p> <div class="sns_inner"> <ul> <li> <p><a href="http://www.mendeley.com/import/?url=https://oasis.postech.ac.kr/handle/2014.oak/28240" target="_blank"><img src="/image/common/mendeley_icon.gif" alt="mendeley" /></a></p> <p class="twitter_box"> <a href="https://twitter.com/share" class="tweet_bt twitter-share-button" data-lang="en" data-size="large" data-dnt="true">트윗하기</a> <script> !function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (!d.getElementById(id)) { js = d.createElement(s); js.id = id; js.src = "//platform.twitter.com/widgets.js"; fjs.parentNode.insertBefore(js, fjs); } }(document, "script", "twitter-wjs"); </script> </p> </li> <li class="facebook_li"> <span id="fb-root"></span> <script> (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/ko_KR/all.js#xfbml=1"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); </script> <span class="fb-like" data-send="true" data-layout="standard" data-width="450" data-show-faces="false" data-font="verdana"></span> </li> </ul> </div> </div> <p class="sns_text"> <span> Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.</span> </p> </div> </div> </div>  <div class="sub_right_box"> <div class="w_cc"> <h4 class="widget_title">Communities & Collection</h4> <ul> <li><a href="/handle/2014.oak/398" class="cc_item">General Graduate School of Life Science (일반대학원 생명과학과)</a> <ul> <li><a href="/handle/2014.oak/399">1. Journal Papers<span class="round_num"><em>2,487</em></span></a></li> <li><a href="/handle/2014.oak/400">2. Conference Papers<span class="round_num"><em>3,466</em></span></a></li> <li><a href="/handle/2014.oak/402">3. Theses_Ph.D.<span class="round_num"><em>443</em></span></a></li> <li><a href="/handle/2014.oak/401">4. Theses_Master<span class="round_num"><em>385</em></span></a></li> <li><a href="/handle/2014.oak/9249">ETC<span class="round_num"><em>0</em></span></a></li> </ul> </li> </ul> </div> <div class="w_researcher"> <h4 class="widget_title">Related Researcher</h4> <div class="researcher_area researcher_area_detail"> <p class="researcher_img_box"><span><img src="" alt="Researcher" onerror="javascript:this.src='/image/common/no_img.gif'"></span></p> <div class="reseacher_info"> <dl> <dt><a href="/researcher-profile?ep=419">노태영<span>ROH, TAE YOUNG</span></a></dt> <dd class="interests_dd">Dept of Life Sciences</dd> </dl> <a href="/researcher-profile?ep=419" class="read_more"><em>Read more</em></a> </div> </div> </div> <script type='text/javascript' src='https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js'></script>  <div class="w_altmetric" id="altmetric_donut"></div> <script> jQuery(function(){ load(); }); function load() { jQuery.ajax({ url: '/json/altmetric/get', data: 'hdl=2014.oak/28240', type: 'get', dataType: 'json', success: function(data) { console.log('altmetric : ' + data.response_message); if (data.response_code == 200) { var html = ""; html += "<h4 class='widget_title'>Altmetric</h4>"; html += "<div class='altmetric_area'>"; html += "<div data-badge-details='right' data-condensed='true' data-badge-type='donut' data-"+ data.identifier + "='" + data.identifier +"' data-hide-no-mentions='true' class='altmetric-embed' id='altmetric-embed'></div>"; html += "</div>"; jQuery("#altmetric_donut").html(html); _altmetric_embed_init(); } }, error: function(err) { console.log(err); } }); } </script> <script type="text/javascript" src="https://www.google.com/jsapi"></script> <script type="text/javascript"> google.load("visualization", "1", {packages:["corechart"]}); google.setOnLoadCallback(drawChart); function drawChart() { var data = google.visualization.arrayToDataTable([ ['Type', 'Count', {role:'style'}], ['View', 855, '#DC3912'], ['Download', 0, ''] ]); var options = { width: '95%', height: 280, title: 'Item View & Download Count', legend: { position: "none" }, series: { 0: { axis: 'View' }, // Bind series 0 to an axis named 'distance'. 1: { axis: 'Download' } // Bind series 1 to an axis named 'brightness'. }, axes: { y: { distance: {label: 'Count'} // Left y-axis. } }, bar: { groupWidth: '30' } }; var chart = new google.visualization.ColumnChart(document.getElementById('item_statistics')); chart.draw(data, options); }; (function($){ $(window).resize(function(){ drawChart(); }); })(jQuery.noConflict()); </script> <div class="w_statistics"> <h4 class="widget_title">Views & Downloads</h4> <div class="item_statistics_area"> <div id="item_statistics" class="chart"></div> </div> </div> </div>  </div> </div> <div class="footer_wrap"> <div class="col_width"> <span class="oak_logo">OAK</span> <div class="footer_address"> <div class="footer_link"> <a href="https://www.postech.ac.kr/privacy-policy" target="_blank">개인정보처리방침</a> <a href="https://www.postech.ac.kr/eng/privacy-policy" target="_blank">Personal Information Protection Policy</a> </div> <p><a href="mailto:library@postech.ac.kr" class="t_mail">library@postech.ac.kr</a> <em class="t_phone">Tel: 054-279-2548</em></p> <p>Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.</p> </div> </div> </div> </div> <div class="sb-slidebar sb-right"> <div class="right_nav_box"> <h3>Browse</h3> <ul> <li><a href="/community-list">Communities & Collections</a></li> <li><a href="/browse-researcher">Researcher</a></li> <li><a href="/browse?type=title">Title</a></li> </ul> <div class="left_quick_link"> <a href="/password-login">Login</a> <a href="http://library.postech.ac.kr">Library</a> <a href="#">Help</a> </div> </div> </div>  <script src="/js/slidebars.js"></script> <script> (function($) { $(function() { $("#slide_wrap").owlCarousel({ autoPlay : 3000, navigation : true, slideSpeed : 300, paginationSpeed : 400, singleItem : true }); $.slidebars(); }); })(jQuery.noConflict()); </script> </body> </html>