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src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1083612" target="_blank" rel="noopener noreferrer">Bo Wang</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/RmR0eHBiNitJN0VodkRQRU9Jc1A3NmdONDlmUDZHYXBsMXRiZElaN3JWbz0=" target="_blank" rel="noopener noreferrer">Anna Kovalchuk</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1070782" target="_blank" rel="noopener noreferrer">Dongping Li</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1411674" target="_blank" rel="noopener noreferrer">Yaroslav Ilnytskyy</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/237562" target="_blank" rel="noopener noreferrer">Igor Kovalchuk</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1052141" target="_blank" rel="noopener noreferrer">Olga Kovalchuk</a></span><sup> *</sup></span></span></div><div class="invisible absolute"><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1083612" target="_blank" rel="noopener noreferrer">Bo Wang</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/RmR0eHBiNitJN0VodkRQRU9Jc1A3NmdONDlmUDZHYXBsMXRiZElaN3JWbz0=" target="_blank" rel="noopener noreferrer">Anna Kovalchuk</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1070782" target="_blank" rel="noopener noreferrer">Dongping Li</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1411674" target="_blank" rel="noopener noreferrer">Yaroslav Ilnytskyy</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/237562" target="_blank" rel="noopener noreferrer">Igor Kovalchuk</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1052141" target="_blank" rel="noopener noreferrer">Olga Kovalchuk</a></span><sup> *</sup></span></span></div></div><div style="display:none;" class="mt-sm"><button class="m-button m-button--sm m-button--tertiary rounded !inline-flex after:hidden bg-white" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center">Show more <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16"></svg></span></button></div></div><p class="m-text text-sm text-color-error pt-sm">This version is not peer-reviewed</p></div><div class="m-accordion mx-auto flex w-full flex-col gap-3 rounded-2xl bg-white"><div class="m-accordion__item border-b border-color-default"><button id="accordion-button-expand-0" aria-controls="accordion-panel-0" class="relative mb-xs flex w-full cursor-pointer py-md text-sm outline-offset-2" aria-expanded="true"><span class="text-sm">This preprints belongs to the Collection</span><div class="absolute right-0 top-1/2 -translate-y-1/2"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="origin-center transition duration-150 rotate-180" style="" width="16" height="16" viewBox="0 0 16 16"></svg></div></button><div id="accordion-panel-0" aria-labelledby="accordion-button-expand-0" role="region" class="m-accordion__body overflow-hidden transition-height duration-150"><div class="break-words pb-md"><div class="flex items-center"><p class="m-text text-sm text-color-link-bold cursor-pointer">Preprints on COVID-19 and SARS-CoV-2</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="arrow_right_alt" class="text-color-link-bold cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16"></svg></div></div></div></div></div></div><div class="py-md border-b border-color-default"><div class="m-select common-field bg-white"><div class="common-field__wrapper" data-headlessui-state><div class="relative w-full cursor-default"><div class="flex items-center"><button id="headlessui-listbox-button-mui-29469" type="button" aria-haspopup="listbox" aria-expanded="false" data-headlessui-state data-testid="select-activator" class="common-field__dropdown-input [&>span]:overflow-hidden h-10"><span class="flex w-full items-center gap-1 [&>span]:truncate"><span>Version 1</span></span><div class="flex"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="duration-400 transition-transform" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></button></div></div></div></div><div class="pt-sm"><div class="flex"><p class="m-text text-xs">Submitted:</p><p class="m-text text-xs pl-xs">17 April 2020</p></div><div class="flex pt-sm"><p class="m-text text-xs">Posted: </p><p class="m-text text-xs pl-xs">19 April 2020</p></div></div><div class="pt-sm"><div><p class="m-text text-xs">You are already at the latest version </p></div></div><div></div></div><div class="py-md border-b border-color-default flex items-center justify-between" data-v-d8c082ee><div class="flex-none flex items-center" data-v-d8c082ee><span class="m-text text-xs pr-xs font-semibold flex-none" data-v-d8c082ee>Alerts</span><span data-v-d8c082ee></span></div><div class="m-switch flex items-center gap-2" data-v-d8c082ee><button class="relative inline-flex h-[1.4rem] w-[2.75rem] shrink-0 cursor-pointer items-center rounded-full border-2 border-color-transparent transition-colors duration-150 ease-out ui-focus-visible:ring-2 ui-focus-visible:ring-brand-bold ui-focus-visible:ring-opacity-75 bg-content-default hover:bg-content-bold active:bg-content-bolder" aria-label="Switch on" id="headlessui-switch-mui-29470" role="switch" type="button" tabindex="0" aria-checked="false" data-headlessui-state><span aria-hidden="true" class="pointer-events-none inline-block h-[1rem] w-[1rem] transform rounded-full bg-white shadow-lg ring-0 transition duration-200 ease-in-out translate-x-0.5"></span></button></div></div><div data-v-d8c082ee data-v-03f1a75d></div><div><h6 class="m-heading text-inherit m-h6 font-semibold pt-lg">Abstract</h6><div class="">With the rapidly growing pandemic of COVID-19 caused by the new and challenging to treat zoonotic SARS-CoV2 coronavirus, there is an urgent need for new therapies and prevention strategies that can help curtail disease spread and reduce mortality. Inhibition of viral entry and thereby spread constitute plausible therapeutic avenues. Similar to other respiratory pathogens, SARS-CoV2 is transmitted through respiratory droplets, with potential for aerosol and contact spread. It uses receptor-mediated entry into the human host via angiotensin-converting enzyme II (ACE2) that is expressed in lung tissue, as well as oral and nasal mucosa, kidney, testes, and the gastrointestinal tract. Modulation of ACE2 levels in these gateway tissues may prove a plausible strategy for decreasing disease susceptibility. Cannabis sativa, especially one high in the anti-inflammatory cannabinoid cannabidiol (CBD), has been proposed to modulate gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties. Working under the Health Canada research license, we have developed over 800 new Cannabis sativa lines and extracts and hypothesized that high-CBD C. sativa extracts may be used to modulate ACE2 expression in COVID-19 target tissues. Screening C. sativa extracts using artificial human 3D models of oral, airway, and intestinal tissues, we identified 13 high CBD C. sativa extracts that modulate ACE2 gene expression and ACE2 protein levels. Our initial data suggest that some C. sativa extract down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV2 entry into host cells. While our most effective extracts require further large-scale validation, our study is crucial for the future analysis of the effects of medical cannabis on COVID-19. The extracts of our most successful and novel high CBD C. sativa lines, pending further investigation, may become a useful and safe addition to the treatment of COVID-19 as an adjunct therapy. They can be used to develop easy-to-use preventative treatments in the form of mouthwash and throat gargle products for both clinical and at-home use. Such products ought to be tested for their potential to decrease viral entry via the oral mucosa. Given the current dire and rapidly evolving epidemiological situation, every possible therapeutic opportunity and avenue must be considered.</div></div><div data-v-3ce94018><div class="pt-lg" data-v-3ce94018><span class="m-text text-body font-semibold" data-v-3ce94018>Keywords: </span><span class="m-text text-body pt-sm" data-v-3ce94018></span></div></div><div class="flex-1 pt-lg mr-lg lg:pt-0" data-v-da90062a><div class="pt-md" data-v-da90062a><div class="flex flex-wrap lg:flex-nowrap items-center" data-v-da90062a><span class="m-text text-body font-semibold" data-v-da90062a>Subject: </span><span class="m-text text-body" data-v-da90062a>Biology and Life Sciences</span><span class="" data-v-da90062a> - </span><span class="m-text text-body" data-v-da90062a>Biochemistry and Molecular Biology</span></div></div><div class="content-container" id="articleRef" data-v-da90062a></div><div class="pt-lg" data-v-da90062a><span class="m-text text-body font-semibold" data-v-da90062a>Copyright: 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Inhibition of viral entry and thereby spread constitute plausible therapeutic avenues. Similar to other respiratory pathogens, SARS-CoV2 is transmitted through respiratory droplets, with potential for aerosol and contact spread. It uses receptor-mediated entry into the human host via angiotensin-converting enzyme II (ACE2) that is expressed in lung tissue, as well as oral and nasal mucosa, kidney, testes, and the gastrointestinal tract. Modulation of ACE2 levels in these gateway tissues may prove a plausible strategy for decreasing disease susceptibility. Cannabis sativa, especially one high in the anti-inflammatory cannabinoid cannabidiol (CBD), has been proposed to modulate gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties. Working under the Health Canada research license, we have developed over 800 new Cannabis sativa lines and extracts and hypothesized that high-CBD C. sativa extracts may be used to modulate ACE2 expression in COVID-19 target tissues. Screening C. sativa extracts using artificial human 3D models of oral, airway, and intestinal tissues, we identified 13 high CBD C. sativa extracts that modulate ACE2 gene expression and ACE2 protein levels. Our initial data suggest that some C. sativa extract down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV2 entry into host cells. While our most effective extracts require further large-scale validation, our study is crucial for the future analysis of the effects of medical cannabis on COVID-19. The extracts of our most successful and novel high CBD C. sativa lines, pending further investigation, may become a useful and safe addition to the treatment of COVID-19 as an adjunct therapy. They can be used to develop easy-to-use preventative treatments in the form of mouthwash and throat gargle products for both clinical and at-home use. Such products ought to be tested for their potential to decrease viral entry via the oral mucosa. Given the current dire and rapidly evolving epidemiological situation, every possible therapeutic opportunity and avenue must be considered.","In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD \u003Cem>Cannabis Sativa\u003C/em> Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues","COVID-19; SARS-CoV2; ACE2 receptor; medical cannabis; CBD",false,[134],{"title":135,"id":7,"name_system":136},"Preprints on COVID-19 and SARS-CoV-2","covid19",{"id":138,"name":139},23,"Biochemistry and Molecular Biology",{"id":52,"name":53},{"id":142,"name":143},15,"Article","2020-04-17 20:21:52","2020-04-19 02:45:50",[147,154,159,164,169,174],{"id":148,"name":149,"email":150,"is_corresponding":132,"orcid_link":47,"author_mark":151,"sp_link":152,"avatar":153},115799,"Bo Wang","bo.wang5@uleth.ca","","https://sciprofiles.com/profile/1083612","/statics/img/design/default-user.png",{"id":155,"name":156,"email":157,"is_corresponding":132,"orcid_link":47,"author_mark":151,"sp_link":158,"avatar":47},115800,"Anna Kovalchuk","anna.kovalchuk1@ucalgary.ca","https://sciprofiles.com/profile/author/RmR0eHBiNitJN0VodkRQRU9Jc1A3NmdONDlmUDZHYXBsMXRiZElaN3JWbz0=",{"id":160,"name":161,"email":162,"is_corresponding":132,"orcid_link":47,"author_mark":151,"sp_link":163,"avatar":153},115801,"Dongping Li","dongping.li@uleth.ca","https://sciprofiles.com/profile/1070782",{"id":165,"name":166,"email":167,"is_corresponding":132,"orcid_link":47,"author_mark":151,"sp_link":168,"avatar":153},115802,"Yaroslav Ilnytskyy","slava.ilyntskyy@uleth.ca","https://sciprofiles.com/profile/1411674",{"id":170,"name":171,"email":172,"is_corresponding":132,"orcid_link":47,"author_mark":151,"sp_link":173,"avatar":153},115803,"Igor Kovalchuk","igor.kovalchuk@uleth.ca","https://sciprofiles.com/profile/237562",{"id":175,"name":176,"email":177,"is_corresponding":6,"orcid_link":47,"author_mark":178,"sp_link":179,"avatar":153},115804,"Olga Kovalchuk","olga.kovalchuk@uleth.ca","*","https://sciprofiles.com/profile/1052141",{"filename":181,"url":182,"filesize":183},"final_file.pdf","/frontend/manuscript/29e56f22d80f1b6d45ef7aefab4783cc/download_pub",956519,[],{"viewed":186,"downloaded":187},"215730","33774",{"score":189,"detail_url":190},988,"https://preprints.altmetric.com/details/doi/10.20944/preprints202004.0315.v1",[192],{"version":7,"hash_key":127,"id":126,"change":47},"Wang, B.; Kovalchuk, A.; Li, D.; Ilnytskyy, Y.; Kovalchuk, I.; Kovalchuk, O. In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD \u003Cem>Cannabis Sativa\u003C/em> Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues. \u003Cem>Preprints\u003C/em> \u003Cb>2020\u003C/b>, 2020040315. https://doi.org/10.20944/preprints202004.0315.v1",[],39,[],{"code":41,"msg":42,"data":198},[199,203],{"id":7,"name":200,"image":201,"url":202,"statistic_type":7},"Author 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Inhibitors of ACE2, the Receptor of 2019-nCoV","https://doi.org/10.20944/preprints202002.0047.v1",[226,229,232,235,238,241],{"name":227,"email":228},"Qinghua Cui","cuiqinghua@bjmu.edu.cn",{"name":230,"email":231},"Chuanbo Huang","huangchuanbo@bjmu.edu.cn",{"name":233,"email":234},"Xiangwen Ji","jxw01@pku.edu.cn",{"name":236,"email":237},"Wanlu Zhang","wanlu_zhou@163.com",{"name":239,"email":240},"Fenghong Zhang","17694892628@163.com",{"name":242,"email":243},"Liang Wang","wangl@jianmutech.com","2020-02-04","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfmtnZ20LUOEtMKyM4-UFmJaNRB1LpyohcF_auW_QUhThSTVnNSafX6EQZOXXlOMsuw",{"doi":47,"title":247,"url":248,"authors":249,"published_at":271,"journal_name":47,"click_trigger_url_hash":272},"Citrus Fruits Are Rich in Flavonoids for Immunoregulation and Potential Targeting ACE2","https://doi.org/",[250,253,256,259,262,265,268],{"name":251,"email":252},"Liping Cheng","chengli-ping@qq.com",{"name":254,"email":255},"Weikang Zheng","zhengweikang@webmail.hzau.edu.cn",{"name":257,"email":258},"Ming Li","823088012@qq.com",{"name":260,"email":261},"Jie Huang","jie.huang@enaca.org",{"name":263,"email":264},"Shuzheng Bao","edumoa@163.com",{"name":266,"email":267},"Qiang Xu","xuqiang@mail.hzau.edu.cn",{"name":269,"email":270},"Zhaocheng Ma","mzhaocheng@mail.hzau.edu.cn","2020-02-23","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfm-kN2tECopPPkK6TAHOIgqseG3TPHjVnwGS9-_BdoQo3bbY3DvqUCxA58itZGzshw",{"doi":274,"title":275,"url":276,"authors":277,"published_at":308,"journal_name":47,"click_trigger_url_hash":309},"10.20944/preprints202307.1239.v1","A mixture of essential oils from three Cretan Aromatic Plants inhibits SARS-CoV-2 proliferation: A Proof-of-Concept intervention study in ambulatory patients","https://doi.org/10.20944/preprints202307.1239.v1",[278,281,284,287,290,293,296,299,302,305],{"name":279,"email":280},"Christos Lionis","lionis@uoc.gr",{"name":282,"email":283},"Elena Petelos","elena.petelos@med.uoc.gr",{"name":285,"email":286},"Manolis Linardakis","linman@med.uoc.gr",{"name":288,"email":289},"Athanasios Diamantakis","a.diamantakis@yahoo.gr",{"name":291,"email":292},"Emmanouil Symvoulakis","esymvoulakis@uoc.gr",{"name":294,"email":295},"Maria-Nefeli Karkana","mnkarkana@gmail.com",{"name":297,"email":298},"Marile Kampa","kampam@uoc.gr",{"name":300,"email":301},"Stergios A Pirintsos","pirintsos@uoc.gr",{"name":303,"email":304},"George Sourvinos","sourving@uoc.gr",{"name":306,"email":307},"Elias 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Li","aljxcr@suda.edu.cn","2020-03-05","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPftKAI9DYixljXJOSDY4uxN3hwuV8FLsq7OVZUpl9YoODOLhv-Dj311Yb72s0o8iYQQ",{"doi":374,"title":375,"url":376,"authors":377,"published_at":386,"journal_name":47,"click_trigger_url_hash":387},"10.20944/preprints202401.2061.v1","Inhibitory Efficacy of Main Components of \u003Cem>Scutellaria baicalensis\u003C/em> on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin Converting Enzyme II","https://doi.org/10.20944/preprints202401.2061.v1",[378,379,380,381,382,385],{"name":332,"email":333},{"name":341,"email":342},{"name":338,"email":339},{"name":344,"email":345},{"name":383,"email":384},"Che-Hsiung Lee","ikemanleee@gmail.com",{"name":347,"email":348},"2024-01-31","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPftbqrvYQxrjL95idDIQObgMJZ_9YXmWBfgLM_YNWnYLp_aOATGkf_fgm7iuxX2i7tQ",{"doi":389,"title":390,"url":391,"authors":392,"published_at":406,"journal_name":47,"click_trigger_url_hash":407},"10.20944/preprints202002.0194.v1","AGTR2, One Possible Novel Key Gene for the Entry of 2019-nCoV into Human Cells","https://doi.org/10.20944/preprints202002.0194.v1",[393,394,397,398,400,401,402,403],{"name":227,"email":228},{"name":395,"email":396},"Chunmei Cui","ccm328@bjmu.edu.cn",{"name":230,"email":231},{"name":399,"email":237},"Wanlu Zhou",{"name":233,"email":234},{"name":239,"email":240},{"name":242,"email":243},{"name":404,"email":405},"Yuan Zhou","zhouyuanbioinfo@bjmu.edu.cn","2020-02-14","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfmWJhxnllwV_94xkwhGYIW7163NPG7Jsvca3_hJerLelwM9kbo5u8gMn2cZAWXkEew",{"doi":47,"title":409,"url":248,"authors":410,"published_at":435,"journal_name":47,"click_trigger_url_hash":436},"Respiratory Virus Infection Is A High-risk Factor for Developing Coronavirus Disease 2019 (COVID-19)",[411,414,417,420,423,426,429,432],{"name":412,"email":413},"MIngyue Chen","807243359@qq.com",{"name":415,"email":416},"Wenxiu Wang","1143844949@qq.com",{"name":418,"email":419},"JIng Yu","116807680@qq.com",{"name":421,"email":422},"Zhou Wang","2797807952@qq.com",{"name":424,"email":425},"Xiaofeng Zheng","1103856554@qq.com",{"name":427,"email":428},"Mingshu Han","1519511655@qq.com",{"name":430,"email":431},"Youwei Zhang","rei0222@foxmail.com",{"name":433,"email":434},"LEi Zhang","zhanglei0222@163.com","2020-10-16","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfgCOKeMbpTqAdkkXj7ykJtONiYENa1MQEPKIQJ2-6OuW2FyA9Q8-KtS8_PVcctOYVQ",{"code":41,"msg":42,"data":438},{"rows":439,"total":507},[440,447,454,460,466,472,478,484,495,501],{"id":441,"is_public":6,"content":442,"username":171,"user_avatar":443,"user_id":444,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":445,"conflicts":47,"children":446},4197,"Good day all,\r\nthe final version of the manuscript accepted in Aging can be found here:\r\n\r\nhttps://www.aging-us.com/article/202225/text\r\n\r\nRegards,\r\nIgor","/frontend/user/user_profile_image?id=237562",237562,"2020-11-24 03:07:12",[],{"id":448,"is_public":6,"content":449,"username":450,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":452,"conflicts":47,"children":453},3761,"The other day I read about this in the article https://www.cannamd.com/marijuana-covid-19-top-studies/ where it was also said that cannabis oil helps to close the gateways through which the covid-19 virus enters the human body. But since this is unconfirmed information, it is difficult to judge that cannabis really helps protect against coronavirus. As I already told my friends at [https://blosumcbd.com/products/|CBD products], these studies are not yet proven, so it cannot be relied upon to help us fight the virus. It is better to keep your immunity strong by eating right, not overcooling, washing your hands regularly, and gently contacting people.","Jacob Clark","/frontend/user/user_profile_image","2020-08-21 17:39:48",[],{"id":455,"is_public":6,"content":456,"username":457,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":458,"conflicts":47,"children":459},3675,"How many of tested cases are canibis smokers.? How many use cbd for other uses??","John holt","2020-08-10 12:54:35",[],{"id":461,"is_public":6,"content":462,"username":463,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":464,"conflicts":47,"children":465},3131,"They do not list which sativas that they used, and while it was extract it can still have terpenes as there was still THC in every one with one of them being over 4%. I am waiting for a full accounting of all these things before deciding anything further, and am curious on why those were not published.\r\n\r\nSome terpenes have antioxidant effect along with anti-inflammation properties. A few have antifungal and can help combat fungus/bacterial growth. One reportedly can help airflow and respiratory functions so you can see why I am curious on any terpene profiles that may have been used.","Brian","2020-05-29 17:59:43",[],{"id":467,"is_public":6,"content":468,"username":469,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":470,"conflicts":47,"children":471},3122,"https://www.immunology.ox.ac.uk/covid-19/covid-19-immunology-literature-reviews/in-search-of-preventative-strategies-novel-anti-inflammatory-high-cbd-cannabis-sativa-extracts-modulate-ace2-expression-in-covid-19-gateway-tissues","Oxford Immunology Review Team","2020-05-28 16:21:04",[],{"id":473,"is_public":6,"content":474,"username":475,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":476,"conflicts":47,"children":477},3099,"Greatt research and excellent comments.\r\nThis is going to get very interesting to see and understand the upcoming new or final results. \r\nFantastic the idea to show the world with this new phenomena, that such a world known famous natural plant the cannabis sativa will be key factor for healing and preventing against this new pathogen.\r\nMany alreadh conducted cientifically proven studies are coming to the conclusion or have come to conclusion that cannabis sativa essencial oils can treat so many and different pathologies attacking the human body as epilepsy, anorexia , most type of cancers, dementia, parkinson, high blood pressure, anxiety, insomnia, as many others.\r\n\r\nThank you so much for sharing and best of luck with your research project.\r\n\r\nJordi Hans","Jordi Hans","2020-05-27 04:14:31",[],{"id":479,"is_public":6,"content":480,"username":481,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":482,"conflicts":47,"children":483},3096,"Chemotypes is the key. They interacts with human behaviors, and those behaviors aren’t same in all humans. Depending the emotions that chemotype is working on a specific human will differ from each to other strain. Immune system is depending of human emotions adequacy and behaviors related. \r\nTerpenes and related emotions are the key on cannabis, much more that those questions of CBD/THC ratio.","Alexandre Benzi","2020-05-26 13:43:52",[],{"id":485,"is_public":6,"content":486,"username":487,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":488,"conflicts":47,"children":489},3082,"THC is immunsuppressive so why not test CBD isolate directly? Thanks for the research!","Dennis Jarvis","2020-05-24 18:19:15",[490],{"id":491,"is_public":6,"content":492,"email":172,"username":171,"affiliation":493,"user_avatar":443,"target_username":47,"target_comment_id":47,"target_user_id":47,"should_call_target":132,"user_id":444,"vote_num":41,"voted":132,"is_screener_report":132,"created_at":494,"conflicts":47},3085,"Yes, we are working on single cannabinoids now.","University of Lethbridge","2020-05-25 06:31:47",{"id":496,"is_public":6,"content":497,"username":498,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":499,"conflicts":47,"children":500},3081,"I love it. I had the idea that cannabis could help in this fight because I recalled how cannabis can signal to cancer cells to stop growing or to die. I'm happy to hear that this is happening and look forward to hearing more about this in the immediate future. Good work fellas.","CeeJay","2020-05-24 13:40:12",[],{"id":502,"is_public":6,"content":503,"username":504,"user_avatar":451,"user_id":47,"vote_num":41,"voted":132,"should_call_target":132,"is_screener_report":132,"created_at":505,"conflicts":47,"children":506},3065,"It is very interesting that this organization points out this was a high CBD extract from a chemovar of cannabis SATIVA. They say they screened 1000s of plants of which only a a few had that characteristic. My guess they found some phenotype higher in \"minor\" cannabinoids and don't want to say, look at the analytics they show THC/CBD only. Aside from this being a blatant advertising plug, it also doesn't factor in terpene content or other cannabinoids which are known to have synergistic effects together with THC and CBD.","Jordan Curl","2020-05-23 09:34:02",[],21,["Reactive",509],{"$scookieConsent":510,"$stoast-ui":511,"$ssite-config":513},{"necessary":6,"functional":132,"statistic":132,"marketing":132,"unclassified":132},{"showToast":132,"toastMessage":151,"toastVariant":512},"neutral",{"env":514,"name":515,"url":516},"production","nuxt-app","http://frontend.preprints.org/",["Set"],["ShallowReactive",519],{"BSkwG22NoT":47,"mgOlEjP40X":47,"Ya7hZzqdE7":47,"98oJwIQOSf":47,"JoG0wWOyMK":47,"FHMk6paVlw":47},"/manuscript/202004.0315/v1",["Reactive",522],{"auth":523,"share-modal":525,"useHeader":526},{"userInfo":524,"isLogin":132},{},{"isShareModalOpen":132,"item":47},{"height":41}]</script> 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