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Noonanin sindrom - Wikipedia

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vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">sakrij</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Uzroci_i_dijagnoza" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Uzroci_i_dijagnoza"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Uzroci i dijagnoza</span> </div> </a> <ul id="toc-Uzroci_i_dijagnoza-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liječenje_i_prognoza" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Liječenje_i_prognoza"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Liječenje i prognoza</span> </div> </a> <ul id="toc-Liječenje_i_prognoza-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Epidemiologija_i_historija" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Epidemiologija_i_historija"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Epidemiologija i historija</span> </div> </a> <ul id="toc-Epidemiologija_i_historija-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vanjski_linkovi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Vanjski_linkovi"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Vanjski linkovi</span> </div> </a> <ul id="toc-Vanjski_linkovi-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Uključi/isključi sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Uključi/isključi sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Noonanin sindrom</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Idi na članak na drugom jeziku. Dostupno na 26 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-26" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">26 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%AA%D9%84%D8%A7%D8%B2%D9%85%D8%A9_%D9%86%D9%88%D9%86%D8%A7%D9%86" title="متلازمة نونان – arapski" lang="ar" hreflang="ar" data-title="متلازمة نونان" data-language-autonym="العربية" data-language-local-name="arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/S%C3%ADndrome_de_Noonan" title="Síndrome de Noonan – katalonski" lang="ca" hreflang="ca" data-title="Síndrome de Noonan" data-language-autonym="Català" data-language-local-name="katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Noonan-Syndrom" title="Noonan-Syndrom – njemački" lang="de" hreflang="de" data-title="Noonan-Syndrom" data-language-autonym="Deutsch" data-language-local-name="njemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Noonan_syndrome" title="Noonan syndrome – engleski" lang="en" hreflang="en" data-title="Noonan syndrome" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/S%C3%ADndrome_de_Noonan" title="Síndrome de Noonan – španski" lang="es" hreflang="es" data-title="Síndrome de Noonan" data-language-autonym="Español" data-language-local-name="španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B3%D9%86%D8%AF%D8%B1%D9%85_%D9%86%D9%88%D9%86%D8%A7%D9%86" title="سندرم نونان – perzijski" lang="fa" hreflang="fa" data-title="سندرم نونان" data-language-autonym="فارسی" data-language-local-name="perzijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Noonanin_oireyhtym%C3%A4" title="Noonanin oireyhtymä – finski" lang="fi" hreflang="fi" data-title="Noonanin oireyhtymä" data-language-autonym="Suomi" data-language-local-name="finski" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Syndrome_de_Noonan" title="Syndrome de Noonan – francuski" lang="fr" hreflang="fr" data-title="Syndrome de Noonan" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%AA%D7%A1%D7%9E%D7%95%D7%A0%D7%AA_%D7%A0%D7%95%D7%A0%D7%90%D7%9F" title="תסמונת נונאן – hebrejski" lang="he" hreflang="he" data-title="תסמונת נונאן" data-language-autonym="עברית" data-language-local-name="hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Noonan-szindr%C3%B3ma" title="Noonan-szindróma – mađarski" lang="hu" hreflang="hu" data-title="Noonan-szindróma" data-language-autonym="Magyar" data-language-local-name="mađarski" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Sindrome_di_Noonan" title="Sindrome di Noonan – italijanski" lang="it" hreflang="it" data-title="Sindrome di Noonan" data-language-autonym="Italiano" data-language-local-name="italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%8C%E3%83%BC%E3%83%8A%E3%83%B3%E7%97%87%E5%80%99%E7%BE%A4" title="ヌーナン症候群 – japanski" lang="ja" hreflang="ja" data-title="ヌーナン症候群" data-language-autonym="日本語" data-language-local-name="japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%9D%D1%83%D0%BD%D0%B0%D0%BD_%D1%81%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC%D1%8B" title="Нунан синдромы – kazaški" lang="kk" hreflang="kk" data-title="Нунан синдромы" data-language-autonym="Қазақша" data-language-local-name="kazaški" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%88%84%EB%82%9C_%EC%A6%9D%ED%9B%84%EA%B5%B0" title="누난 증후군 – korejski" lang="ko" hreflang="ko" data-title="누난 증후군" data-language-autonym="한국어" data-language-local-name="korejski" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Syndroom_van_Noonan" title="Syndroom van Noonan – nizozemski" lang="nl" hreflang="nl" data-title="Syndroom van Noonan" data-language-autonym="Nederlands" data-language-local-name="nizozemski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%A8%E0%AD%81%E0%AC%A8%E0%AC%BE%E0%AC%A8_%E0%AC%B8%E0%AC%BF%E0%AC%A3%E0%AD%8D%E0%AC%A1%E0%AD%8D%E0%AC%B0%E0%AD%8B%E0%AC%AE" title="ନୁନାନ ସିଣ୍ଡ୍ରୋମ – odija" lang="or" hreflang="or" data-title="ନୁନାନ ସିଣ୍ଡ୍ରୋମ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odija" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Zesp%C3%B3%C5%82_Noonan" title="Zespół Noonan – poljski" lang="pl" hreflang="pl" data-title="Zespół Noonan" data-language-autonym="Polski" data-language-local-name="poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/S%C3%ADndrome_de_Noonan" title="Síndrome de Noonan – portugalski" lang="pt" hreflang="pt" data-title="Síndrome de Noonan" data-language-autonym="Português" data-language-local-name="portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A1%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC_%D0%9D%D1%83%D0%BD%D0%B0%D0%BD" title="Синдром Нунан – ruski" lang="ru" hreflang="ru" data-title="Синдром Нунан" data-language-autonym="Русский" data-language-local-name="ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%9D%D1%83%D0%BD%D0%B0%D0%BD%D0%BE%D0%B2_%D1%81%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC" title="Нунанов синдром – srpski" lang="sr" hreflang="sr" data-title="Нунанов синдром" data-language-autonym="Српски / srpski" data-language-local-name="srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Noonans_syndrom" title="Noonans syndrom – švedski" lang="sv" hreflang="sv" data-title="Noonans syndrom" data-language-autonym="Svenska" data-language-local-name="švedski" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%81%E0%B8%A5%E0%B8%B8%E0%B9%88%E0%B8%A1%E0%B8%AD%E0%B8%B2%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%99%E0%B8%B9%E0%B9%81%E0%B8%99%E0%B8%99" title="กลุ่มอาการนูแนน – tajlandski" lang="th" hreflang="th" data-title="กลุ่มอาการนูแนน" data-language-autonym="ไทย" data-language-local-name="tajlandski" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Noonan_sendromu" title="Noonan sendromu – turski" lang="tr" hreflang="tr" data-title="Noonan sendromu" data-language-autonym="Türkçe" data-language-local-name="turski" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Nunan_sindromi" title="Nunan sindromi – uzbečki" lang="uz" hreflang="uz" data-title="Nunan sindromi" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbečki" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/H%E1%BB%99i_ch%E1%BB%A9ng_Noonan" title="Hội chứng Noonan – vijetnamski" lang="vi" hreflang="vi" data-title="Hội chứng Noonan" data-language-autonym="Tiếng Việt" data-language-local-name="vijetnamski" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%8A%AA%E5%8D%97%E6%B0%8F%E7%97%87%E5%80%99%E7%BE%A4" title="努南氏症候群 – kineski" lang="zh" hreflang="zh" data-title="努南氏症候群" data-language-autonym="中文" data-language-local-name="kineski" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1543446#sitelinks-wikipedia" title="Uredi međujezičke linkove" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Noonanin_sindrom" title="Prikaži stranicu sa sadržajem [c]" 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vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Izgled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">sakrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">S Wikipedije, slobodne enciklopedije</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="bs" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r3638947">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data div{background:#1f1f23!important;color:#f8f9fa}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background:#DCDCDC;">Noonanov sindrom<br />(Muški Turnerov sindrom, Noonan-Ehmkeov sindrom, <br />Turneroliki sindrom, <br />Ullrich-Noonanov sindrom<sup id="cite_ref-GHR2018_1-0" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/Datoteka:Noonan_syndrome.PNG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/69/Noonan_syndrome.PNG/220px-Noonan_syndrome.PNG" decoding="async" width="220" height="188" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/69/Noonan_syndrome.PNG/330px-Noonan_syndrome.PNG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/69/Noonan_syndrome.PNG/440px-Noonan_syndrome.PNG 2x" data-file-width="753" data-file-height="645" /></a></span></td></tr><tr><th colspan="2" class="infobox-header">Klasifikacija i vanjski resursi</th></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medicinske_klasifikacije" title="Medicinske klasifikacije">ICD</a>-<a href="/wiki/MKB_10" title="MKB 10">10</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://icd.who.int/browse10/2019/en#/Q87.1">Q87.1</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medicinske_klasifikacije" title="Medicinske klasifikacije">ICD</a>-<a href="/wiki/MKB_9" class="mw-redirect" title="MKB 9">9</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=759.89">759.89</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/OMIM" title="OMIM">OMIM</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/163950">163950</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/605275">605275</a> <p><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/609942">609942</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/610733">610733</a> </p> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/omim/611553">611553</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Diseases_Database" title="Diseases Database">DiseasesDB</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb29094.htm">29094</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/medlineplus/ency/article/001656.htm">001656</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/EMedicine" title="EMedicine">eMedicine</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://emedicine.medscape.com/article/947504-overview">article/947504</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/cgi/mesh/2010/MB_cgi?field=uid&amp;term=D009634">D009634</a></td></tr><tr><th scope="row" class="infobox-label"><a href="/w/index.php?title=GeneReviews&amp;action=edit&amp;redlink=1" class="new" title="GeneReviews (stranica ne postoji)">GeneReviews</a></th><td class="infobox-data">Noonan Syndrome</td></tr></tbody></table> <p><b>Noonanin sindrim</b>, poznatiji kao <b>Noonanov sindrom</b> (<b>NS</b>) je <a href="/wiki/Geneti%C4%8Dki_poreme%C4%87aj" title="Genetički poremećaj">genetički poremećaj</a> koji se može ispoljavati kao blago neuobičajene crte lica, mala visina, <a href="/w/index.php?title=Priro%C4%91ena_bolest_srca&amp;action=edit&amp;redlink=1" class="new" title="Prirođena bolest srca (stranica ne postoji)">prirođena bolest srca</a>, <a href="/wiki/Krvarenje" title="Krvarenje">problemi s krvarenjem</a> i <a href="/wiki/Skelet" class="mw-redirect" title="Skelet">skeletne</a> malformacije.<sup id="cite_ref-GHR2018_1-1" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p><p>Obilježja lica uključuju široko razmaknute oči, svijetleoči, slabo postavljene uši, kratak vrat i malu donju vilicu.<sup id="cite_ref-GHR2018_1-2" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup>Srčani problemi mogu uključivati stenozu plućnog ventila]]. <a href="/wiki/Grudna_kost" title="Grudna kost">Grudna kost</a> može biti izbočena ili biti udubljena, dok <a href="/wiki/Skolioza" title="Skolioza">kičma može biti abnormalno zakrivljena</a>,<sup id="cite_ref-GHR2018_1-3" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup>a <a href="/wiki/Inteligencija" title="Inteligencija">inteligencija</a> je često normalna.<sup id="cite_ref-GHR2018_1-4" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Komplikacije mogu uključivati i <a href="/wiki/Leukemija" title="Leukemija">leukemiju</a>.<sup id="cite_ref-GHR2018_1-5" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Uzroci_i_dijagnoza">Uzroci i dijagnoza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Noonanin_sindrom&amp;veaction=edit&amp;section=1" title="Uredi odlomak &quot;Uzroci i dijagnoza&quot;" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Noonanin_sindrom&amp;action=edit&amp;section=1" title="Edit section&#039;s source code: Uzroci i dijagnoza"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Brojne <a href="/wiki/Mutacija" title="Mutacija">genetičke mutacije</a> mogu rezultirati Noonaninim sindromom. <sup id="cite_ref-GHR2018_1-6" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Stanje može biti <a href="/wiki/Naslje%C4%91ivanje" title="Nasljeđivanje">naslijeđeno od roditelja</a> kao <a href="/wiki/Interakcija_gena" title="Interakcija gena">autosomno dominantno stanje</a> ili kao nove mutacije tokom ranog razvoja.<sup id="cite_ref-NIH2018_2-0" class="reference"><a href="#cite_note-NIH2018-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-GHR2018_1-7" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Noonanov sindrom je vrsta <a href="/w/index.php?title=RASopatija&amp;action=edit&amp;redlink=1" class="new" title="RASopatija (stranica ne postoji)">RASopatije</a>, čiji temeljni mehanizam uključuje problem s <a href="/wiki/%C4%86elijska_signalizacija" class="mw-redirect" title="Ćelijska signalizacija">ćelijsku signalizaciju</a>.<sup id="cite_ref-GHR2018_1-8" class="reference"><a href="#cite_note-GHR2018-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> Dijagnoza se može postaviti na temelju simptoma, medicinskih nalazai krvnih pretraga.<sup id="cite_ref-NORD2016_3-0" class="reference"><a href="#cite_note-NORD2016-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-AFP2014_4-0" class="reference"><a href="#cite_note-AFP2014-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> Potvrda se može postići <a href="/wiki/Geneti%C4%8Dko_testiranje" title="Genetičko testiranje">genetičkim testiranjem</a>.<sup id="cite_ref-NORD2016_3-1" class="reference"><a href="#cite_note-NORD2016-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:InfantWithNoonan1.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/InfantWithNoonan1.jpg/220px-InfantWithNoonan1.jpg" decoding="async" width="220" height="294" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/InfantWithNoonan1.jpg/330px-InfantWithNoonan1.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/01/InfantWithNoonan1.jpg/440px-InfantWithNoonan1.jpg 2x" data-file-width="902" data-file-height="1205" /></a><figcaption> Nenormalna obilježja Noonaninog sindroma u dobi od tri mjeseci: nagib obrva i spuštnost lijevog očnog kapaka.<sup id="cite_ref-Nos2013_5-0" class="reference"><a href="#cite_note-Nos2013-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup></figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:InfantWithNoonan2.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/InfantWithNoonan2.jpg/220px-InfantWithNoonan2.jpg" decoding="async" width="220" height="285" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/InfantWithNoonan2.jpg/330px-InfantWithNoonan2.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7f/InfantWithNoonan2.jpg/440px-InfantWithNoonan2.jpg 2x" data-file-width="903" data-file-height="1170" /></a><figcaption>Noonanov sindrom kod tromjesečnog djeteta: slabo postavljeno, zakrenuto i nenormalno oblikovano uho.<sup id="cite_ref-Nos2013_5-1" class="reference"><a href="#cite_note-Nos2013-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup></figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Liječenje_i_prognoza"><span id="Lije.C4.8Denje_i_prognoza"></span>Liječenje i prognoza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Noonanin_sindrom&amp;veaction=edit&amp;section=2" title="Uredi odlomak &quot;Liječenje i prognoza&quot;" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Noonanin_sindrom&amp;action=edit&amp;section=2" title="Edit section&#039;s source code: Liječenje i prognoza"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="box-Prijevod plainlinks metadata ambox ambox-content" role="presentation"><tbody><tr><td class="mbox-image"><div style="width:52px"><span typeof="mw:File"><a href="/wiki/Datoteka:Translation_Latin_Alphabet-cs.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Translation_Latin_Alphabet-cs.svg/50px-Translation_Latin_Alphabet-cs.svg.png" decoding="async" width="50" height="20" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Translation_Latin_Alphabet-cs.svg/75px-Translation_Latin_Alphabet-cs.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Translation_Latin_Alphabet-cs.svg/100px-Translation_Latin_Alphabet-cs.svg.png 2x" data-file-width="476" data-file-height="189" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span"><b>Ovaj članak nije preveden ili je djelimično preveden</b>.<span class="hide-when-compact"> Ako smatrate da ste ga sposobni prevesti, kliknite na "<span class="plainlinks"><a class="external text" href="https://bs.wikipedia.org/w/index.php?title=Noonanin_sindrom&amp;action=edit"><b>Uredi</b></a></span>" i prevedite ga vodeći računa o enciklopedijskom stilu pisanja i <a href="/wiki/Wikipedia:Pravilno-nepravilno_u_bosanskom_jeziku" title="Wikipedia:Pravilno-nepravilno u bosanskom jeziku">pravopisu</a> <a href="/wiki/Bosanski_jezik" title="Bosanski jezik">bosanskog jezika</a>.</span></div></td></tr></tbody></table> <p>Lijek za ovaj sindrom nije poznat.<sup id="cite_ref-Mer2018_6-0" class="reference"><a href="#cite_note-Mer2018-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> Liječenje se zasniva na simptomima i pratećim problemima.<sup id="cite_ref-NIH2018_2-1" class="reference"><a href="#cite_note-NIH2018-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> Special help in school may be required.<sup id="cite_ref-NIH2018_2-2" class="reference"><a href="#cite_note-NIH2018-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> Tokom djetilnjstva, <a href="/wiki/Hormon_rasta" title="Hormon rasta">hormon rasta</a> može povećati krajnju visinu odrasle osobe.<sup id="cite_ref-NIH2018_2-3" class="reference"><a href="#cite_note-NIH2018-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> Long-term outcomes typically depend on the severity of heart problems.<sup id="cite_ref-NIH2018_2-4" class="reference"><a href="#cite_note-NIH2018-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiologija_i_historija">Epidemiologija i historija</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Noonanin_sindrom&amp;veaction=edit&amp;section=3" title="Uredi odlomak &quot;Epidemiologija i historija&quot;" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Noonanin_sindrom&amp;action=edit&amp;section=3" title="Edit section&#039;s source code: Epidemiologija i historija"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Procjenjuje se da je jedna od 100 osoba blago pogođena, dok otprilike jedna u 2000 ima teži oblik bolesti.<sup id="cite_ref-AFP2014_4-1" class="reference"><a href="#cite_note-AFP2014-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> Muškarci su češće pogođeni od žena.<sup id="cite_ref-NORD2016_3-2" class="reference"><a href="#cite_note-NORD2016-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> Stanje je prvi put opisano 1883. Godine, a ime je dobilo po <a href="/w/index.php?title=Jacqueline_Noonan&amp;action=edit&amp;redlink=1" class="new" title="Jacqueline Noonan (stranica ne postoji)">Jacqueline Noonan</a> koja je opisala daljnje slučajeve 1963.<sup id="cite_ref-NORD2016_3-3" class="reference"><a href="#cite_note-NORD2016-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Noonanin_sindrom&amp;veaction=edit&amp;section=4" title="Uredi odlomak &quot;Reference&quot;" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Noonanin_sindrom&amp;action=edit&amp;section=4" title="Edit section&#039;s source code: Reference"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3312388">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-GHR2018-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-GHR2018_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-GHR2018_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-GHR2018_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-GHR2018_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-GHR2018_1-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-GHR2018_1-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-GHR2018_1-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-GHR2018_1-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-GHR2018_1-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r3303350">.mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://ghr.nlm.nih.gov/condition/noonan-syndrome">"Noonan syndrome"</a>. <i>Genetics Home Reference</i><span class="reference-accessdate">. Pristupljeno <span class="nowrap">24 December</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Genetics+Home+Reference&amp;rft.atitle=Noonan+syndrome&amp;rft_id=https%3A%2F%2Fghr.nlm.nih.gov%2Fcondition%2Fnoonan-syndrome&amp;rfr_id=info%3Asid%2Fbs.wikipedia.org%3ANoonanin+sindrom" class="Z3988"></span></span> </li> <li id="cite_note-NIH2018-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-NIH2018_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-NIH2018_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-NIH2018_2-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-NIH2018_2-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-NIH2018_2-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://rarediseases.info.nih.gov/diseases/10955/noonan-syndrome">"Noonan syndrome"</a>. <i>Genetic and Rare Diseases Information Center (GARD) – an NCATS Program</i><span class="reference-accessdate">. Pristupljeno <span class="nowrap">25 December</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Genetic+and+Rare+Diseases+Information+Center+%28GARD%29+%E2%80%93+an+NCATS+Program&amp;rft.atitle=Noonan+syndrome&amp;rft_id=https%3A%2F%2Frarediseases.info.nih.gov%2Fdiseases%2F10955%2Fnoonan-syndrome&amp;rfr_id=info%3Asid%2Fbs.wikipedia.org%3ANoonanin+sindrom" class="Z3988"></span></span> </li> <li id="cite_note-NORD2016-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-NORD2016_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-NORD2016_3-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-NORD2016_3-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-NORD2016_3-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://rarediseases.org/rare-diseases/noonan-syndrome/">"Noonan Syndrome"</a>. <i>NORD (National Organization for Rare Disorders)</i>. 2016<span class="reference-accessdate">. Pristupljeno <span class="nowrap">24 December</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=NORD+%28National+Organization+for+Rare+Disorders%29&amp;rft.atitle=Noonan+Syndrome&amp;rft.date=2016&amp;rft_id=https%3A%2F%2Frarediseases.org%2Frare-diseases%2Fnoonan-syndrome%2F&amp;rfr_id=info%3Asid%2Fbs.wikipedia.org%3ANoonanin+sindrom" class="Z3988"></span></span> </li> <li id="cite_note-AFP2014-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-AFP2014_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AFP2014_4-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFBhambhaniMuenke2014" class="citation journal cs1">Bhambhani V, Muenke M (January 2014). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC4099190">"Noonan syndrome"</a>. <i>American Family Physician</i>. <b>89</b> (1): 37–43. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a>&#160;<span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC4099190">4099190</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24444506">24444506</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=American+Family+Physician&amp;rft.atitle=Noonan+syndrome&amp;rft.volume=89&amp;rft.issue=1&amp;rft.pages=37-43&amp;rft.date=2014-01&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4099190%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F24444506&amp;rft.aulast=Bhambhani&amp;rft.aufirst=V&amp;rft.au=Muenke%2C+M&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4099190&amp;rfr_id=info%3Asid%2Fbs.wikipedia.org%3ANoonanin+sindrom" class="Z3988"></span></span> </li> <li id="cite_note-Nos2013-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-Nos2013_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Nos2013_5-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite id="CITEREFNosanBertokVeselYntema2013" class="citation journal cs1">Nosan G, Bertok S, Vesel S, Yntema HG, Paro-Panjan D (December 2013). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3893993">"A lethal course of hypertrophic cardiomyopathy in Noonan syndrome due to a novel germline mutation in the KRAS gene: case study"</a>. <i>Croatian Medical Journal</i>. <b>54</b> (6): 574–8. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3325%2Fcmj.2013.54.574">10.3325/cmj.2013.54.574</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a>&#160;<span class="cs1-lock-free" title="Slobodno dostupno"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3893993">3893993</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a>&#160;<a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24382853">24382853</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Croatian+Medical+Journal&amp;rft.atitle=A+lethal+course+of+hypertrophic+cardiomyopathy+in+Noonan+syndrome+due+to+a+novel+germline+mutation+in+the+KRAS+gene%3A+case+study&amp;rft.volume=54&amp;rft.issue=6&amp;rft.pages=574-8&amp;rft.date=2013-12&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3893993%23id-name%3DPMC&amp;rft_id=info%3Apmid%2F24382853&amp;rft_id=info%3Adoi%2F10.3325%2Fcmj.2013.54.574&amp;rft.aulast=Nosan&amp;rft.aufirst=G&amp;rft.au=Bertok%2C+S&amp;rft.au=Vesel%2C+S&amp;rft.au=Yntema%2C+HG&amp;rft.au=Paro-Panjan%2C+D&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3893993&amp;rfr_id=info%3Asid%2Fbs.wikipedia.org%3ANoonanin+sindrom" class="Z3988"></span></span> </li> <li id="cite_note-Mer2018-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-Mer2018_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r3303350"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.merckmanuals.com/home/children-s-health-issues/chromosome-and-gene-abnormalities/noonan-syndrome">"Noonan Syndrome - Children's Health Issues"</a>. <i>Merck Manuals Consumer Version</i><span class="reference-accessdate">. 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