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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">NCAN</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/2465">NCAN</a></span>, CSPG3, neurocan</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600826">600826</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:104694">104694</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=3229">3229</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAN">NCAN</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000130287">NCAN - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (human)"><img alt="Chromosome 19 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/450px-Ideogram_human_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/600px-Ideogram_human_chromosome_19.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_19_(human)" class="mw-redirect" title="Chromosome 19 (human)">Chromosome 19 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_19_ideogram.svg" class="mw-file-description" title="Chromosome 19 (human)"><img alt="Chromosome 19 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/300px-Human_chromosome_19_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/450px-Human_chromosome_19_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Human_chromosome_19_ideogram.svg/600px-Human_chromosome_19_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 91.103375233148px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for NCAN"><img alt="Genomic location for NCAN" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 97.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for NCAN"><img alt="Genomic location for NCAN" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19p13.11</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">19,211,958 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">19,252,233 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/390px-Ideogram_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/520px-Ideogram_house_mouse_chromosome_8.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 8 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/300px-Ideogram_of_house_mouse_chromosome_8.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/450px-Ideogram_of_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/600px-Ideogram_of_house_mouse_chromosome_8.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 154.98435025012px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for NCAN"><img alt="Genomic location for NCAN" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 161px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for NCAN"><img alt="Genomic location for NCAN" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">8 B3.3|8 34.15 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">70,545,735 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">70,573,523 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000130287">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">Region I of hippocampus proper</li><br /><li style="line-height: 137%;">postcentral gyrus</li><br /><li style="line-height: 137%;">superior frontal gyrus</li><br /><li style="line-height: 137%;">middle frontal gyrus</li><br /><li style="line-height: 137%;">entorhinal cortex</li><br /><li style="line-height: 137%;">Brodmann area 46</li><br /><li style="line-height: 137%;">frontal pole</li><br /><li style="line-height: 137%;">Brodmann area 10</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000002341">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">olfactory bulb</li><br /><li style="line-height: 137%;">Rostral migratory stream</li><br /><li style="line-height: 137%;">olfactory tubercle</li><br /><li style="line-height: 137%;">prefrontal cortex</li><br /><li style="line-height: 137%;">barrel cortex</li><br /><li style="line-height: 137%;">nucleus accumbens</li><br /><li style="line-height: 137%;">superior frontal gyrus</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000130287">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005540">hyaluronic acid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030246">carbohydrate binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005201">extracellular matrix structural constituent</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005796">Golgi lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043202">lysosomal lumen</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030207">chondroitin sulfate catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001501">skeletal system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007417">central nervous system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030206">chondroitin sulfate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030198">extracellular matrix organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030208">dermatan sulfate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1463&rn=1">1463</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13004&rn=1">13004</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000130287;db=core">ENSG00000130287</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000002341;db=core">ENSMUSG00000002341</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O14594">O14594</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P55066">P55066</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004386">NM_004386</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007789">NM_007789</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004377">NP_004377</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031815">NP_031815</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr19:19211958-19252233">Chr 19: 19.21 – 19.25 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr8:70545735-70573523">Chr 8: 70.55 – 70.57 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q15996896" class="extiw" title="d:Q15996896">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18248562" class="extiw" title="d:Q18248562">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Neurocan core protein</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>NCAN</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1326557_5-0" class="reference"><a href="#cite_note-pmid1326557-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p><b>Neurocan</b> is a member of the <a href="/wiki/Lectican" title="Lectican">lectican</a> / <a href="/wiki/Chondroitin_sulfate_proteoglycan" title="Chondroitin sulfate proteoglycan">chondroitin sulfate proteoglycan</a> protein families and consists of neurocan core protein and <a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">chondroitin sulfate</a>. It is thought to be involved in the modulation of <a href="/wiki/Cell_adhesion" title="Cell adhesion">cell adhesion</a> and migration.<sup id="cite_ref-entrez_6-1" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_bipolar_disorder">Role in bipolar disorder</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Neurocan&action=edit&section=1" title="Edit section: Role in bipolar disorder"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Neurocan is a significant component of the extracellular matrix, and its levels are modulated by a variety of factors, but mice in which the NCAN gene has been knocked out show no easily observable defects in brain development or behavior.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> However, a genome-wide association study published in 2011 identified Neurocan as a susceptibility factor for <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> A more comprehensive study published in 2012 confirmed that association.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The 2012 study examined correlations between NCAN alleles and various symptoms of bipolar disorder, and also examined the behavior of NCAN knockout mice. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Neurocan&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000130287">GRCh38: Ensembl release 89: ENSG00000130287</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000002341">GRCm38: Ensembl release 89: ENSMUSG00000002341</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1463">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D1463&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link 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Genet</i>. <b>88</b> (3): 372–81. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ajhg.2011.01.017">10.1016/j.ajhg.2011.01.017</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059436">3059436</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21353194">21353194</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Hum.+Genet.&rft.atitle=Genome-wide+association+study+identifies+genetic+variation+in+neurocan+as+a+susceptibility+factor+for+bipolar+disorder&rft.volume=88&rft.issue=3&rft.pages=372-81&rft.date=2011-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3059436%23id-name%3DPMC&rft_id=info%3Apmid%2F21353194&rft_id=info%3Adoi%2F10.1016%2Fj.ajhg.2011.01.017&rft.aulast=Cichon&rft.aufirst=S&rft.au=M%C3%BChleisen%2C+TW&rft.au=Degenhardt%2C+FA&rft.au=Mattheisen%2C+M&rft.au=Mir%C3%B3%2C+X&rft.au=Strohmaier%2C+J&rft.au=Steffens%2C+M&rft.au=Meesters%2C+C&rft.au=Herms%2C+S&rft.au=Weingarten%2C+M&rft.au=Priebe%2C+L&rft.au=Haenisch%2C+B&rft.au=Alexander%2C+M&rft.au=Vollmer%2C+J&rft.au=Breuer%2C+R&rft.au=Schm%C3%A4l%2C+C&rft.au=Tessmann%2C+P&rft.au=Moebus%2C+S&rft.au=Wichmann%2C+HE&rft.au=Schreiber%2C+S&rft.au=M%C3%BCller-Myhsok%2C+B&rft.au=Lucae%2C+S&rft.au=Jamain%2C+S&rft.au=Leboyer%2C+M&rft.au=Bellivier%2C+F&rft.au=Etain%2C+B&rft.au=Henry%2C+C&rft.au=Kahn%2C+JP&rft.au=Heath%2C+S&rft.au=Hamshere%2C+M&rft.au=O%27Donovan%2C+MC&rft.au=Owen%2C+MJ&rft.au=Craddock%2C+N&rft.au=Schwarz%2C+M&rft.au=Vedder%2C+H&rft.au=Kammerer-Ciernioch%2C+J&rft.au=Reif%2C+A&rft.au=Sasse%2C+J&rft.au=Bauer%2C+M&rft.au=Hautzinger%2C+M&rft.au=Wright%2C+A&rft.au=Mitchell%2C+PB&rft.au=Schofield%2C+PR&rft.au=Montgomery%2C+GW&rft.au=Medland%2C+SE&rft.au=Gordon%2C+SD&rft.au=Martin%2C+NG&rft.au=Gustafsson%2C+O&rft.au=Andreassen%2C+O&rft.au=Djurovic%2C+S&rft.au=Sigurdsson%2C+E&rft.au=Steinberg%2C+S&rft.au=Stefansson%2C+H&rft.au=Stefansson%2C+K&rft.au=Kapur-Pojskic%2C+L&rft.au=Oruc%2C+L&rft.au=Rivas%2C+F&rft.au=Mayoral%2C+F&rft.au=Chuchalin%2C+A&rft.au=Babadjanova%2C+G&rft.au=Tiganov%2C+AS&rft.au=Pantelejeva%2C+G&rft.au=Abramova%2C+LI&rft.au=Grigoroiu-Serbanescu%2C+M&rft.au=Diaconu%2C+CC&rft.au=Czerski%2C+PM&rft.au=Hauser%2C+J&rft.au=Zimmer%2C+A&rft.au=Lathrop%2C+M&rft.au=Schulze%2C+TG&rft.au=Wienker%2C+TF&rft.au=Schumacher%2C+J&rft.au=Maier%2C+W&rft.au=Propping%2C+P&rft.au=Rietschel%2C+M&rft.au=N%C3%B6then%2C+MM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3059436&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMiróMeierDreisowFrank2012" class="citation journal cs1">Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". <i>Am J Psychiatry</i>. <b>169</b> (9): 982–90. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1176%2Fappi.ajp.2012.11101585">10.1176/appi.ajp.2012.11101585</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22952076">22952076</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:13621844">13621844</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am+J+Psychiatry&rft.atitle=Studies+in+humans+and+mice+implicate+neurocan+in+the+etiology+of+mania&rft.volume=169&rft.issue=9&rft.pages=982-90&rft.date=2012-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A13621844%23id-name%3DS2CID&rft_id=info%3Apmid%2F22952076&rft_id=info%3Adoi%2F10.1176%2Fappi.ajp.2012.11101585&rft.aulast=Mir%C3%B3&rft.aufirst=X&rft.au=Meier%2C+S&rft.au=Dreisow%2C+ML&rft.au=Frank%2C+J&rft.au=Strohmaier%2C+J&rft.au=Breuer%2C+R&rft.au=Schm%C3%A4l%2C+C&rft.au=Albayram%2C+%C3%96&rft.au=Pardo-Olmedilla%2C+MT&rft.au=M%C3%BChleisen%2C+TW&rft.au=Degenhardt%2C+FA&rft.au=Mattheisen%2C+M&rft.au=Reinhard%2C+I&rft.au=Bilkei-Gorzo%2C+A&rft.au=Cichon%2C+S&rft.au=Seidenbecher%2C+C&rft.au=Rietschel%2C+M&rft.au=N%C3%B6then%2C+MM&rft.au=Zimmer%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Neurocan&action=edit&section=3" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRauchGrimpeKulbeArnold-Ammer1996" class="citation journal cs1">Rauch U, Grimpe B, Kulbe G, Arnold-Ammer I, Beier DR, Fässler R (1996). "Structure and chromosomal localization of the mouse neurocan gene". <i>Genomics</i>. <b>28</b> (3): 405–10. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1995.1168">10.1006/geno.1995.1168</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7490074">7490074</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Structure+and+chromosomal+localization+of+the+mouse+neurocan+gene.&rft.volume=28&rft.issue=3&rft.pages=405-10&rft.date=1996&rft_id=info%3Adoi%2F10.1006%2Fgeno.1995.1168&rft_id=info%3Apmid%2F7490074&rft.aulast=Rauch&rft.aufirst=U&rft.au=Grimpe%2C+B&rft.au=Kulbe%2C+G&rft.au=Arnold-Ammer%2C+I&rft.au=Beier%2C+DR&rft.au=F%C3%A4ssler%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFriedlanderMilevKarthikeyanMargolis1994" class="citation journal cs1">Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M (1994). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119998">"The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth"</a>. <i>J. Cell Biol</i>. <b>125</b> (3): 669–80. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.125.3.669">10.1083/jcb.125.3.669</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119998">2119998</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7513709">7513709</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Biol.&rft.atitle=The+neuronal+chondroitin+sulfate+proteoglycan+neurocan+binds+to+the+neural+cell+adhesion+molecules+Ng-CAM%2FL1%2FNILE+and+N-CAM%2C+and+inhibits+neuronal+adhesion+and+neurite+outgrowth.&rft.volume=125&rft.issue=3&rft.pages=669-80&rft.date=1994&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2119998%23id-name%3DPMC&rft_id=info%3Apmid%2F7513709&rft_id=info%3Adoi%2F10.1083%2Fjcb.125.3.669&rft.aulast=Friedlander&rft.aufirst=DR&rft.au=Milev%2C+P&rft.au=Karthikeyan%2C+L&rft.au=Margolis%2C+RK&rft.au=Margolis%2C+RU&rft.au=Grumet%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2119998&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMilevMaurelHäringMargolis1996" class="citation journal cs1">Milev P, Maurel P, Häring M, Margolis RK, Margolis RU (1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.26.15716">"TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM"</a>. <i>J. Biol. Chem</i>. <b>271</b> (26): 15716–23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.26.15716">10.1074/jbc.271.26.15716</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8663515">8663515</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=TAG-1%2Faxonin-1+is+a+high-affinity+ligand+of+neurocan%2C+phosphacan%2Fprotein-tyrosine+phosphatase-zeta%2Fbeta%2C+and+N-CAM.&rft.volume=271&rft.issue=26&rft.pages=15716-23&rft.date=1996&rft_id=info%3Adoi%2F10.1074%2Fjbc.271.26.15716&rft_id=info%3Apmid%2F8663515&rft.aulast=Milev&rft.aufirst=P&rft.au=Maurel%2C+P&rft.au=H%C3%A4ring%2C+M&rft.au=Margolis%2C+RK&rft.au=Margolis%2C+RU&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.271.26.15716&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANeurocan" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRetzlerGöhringRauch1996" class="citation journal cs1">Retzler C, Göhring W, Rauch U (1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.44.27304">"Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM"</a>. <i>J. 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"Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". <i>Nat. Biotechnol</i>. <b>22</b> (6): 707–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnbt971">10.1038/nbt971</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15146197">15146197</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27764390">27764390</a>.</cite><span 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Lectins" title="Template:Lectins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Lectins" title="Template talk:Lectins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Lectins" title="Special:EditPage/Template:Lectins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein:_lectins" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>: <a href="/wiki/Lectin" title="Lectin">lectins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Animal</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/C-type_lectin" title="C-type lectin">C-type lectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asialoglycoprotein_receptor" title="Asialoglycoprotein receptor">Asialoglycoprotein receptor</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">KLRD1</a></li> <li><a href="/wiki/Collectin" title="Collectin">Collectin</a> <ul><li><a href="/wiki/Mannan-binding_lectin" title="Mannan-binding lectin">Mannan-binding lectin</a></li></ul></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">Mannose receptor</a></li> <li><i><a href="/wiki/Proteochondroitin_sulfate" class="mw-redirect" title="Proteochondroitin sulfate">proteochondroitin sulfate</a></i> <ul><li><a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a class="mw-selflink selflink">Neurocan</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/SIGLEC" class="mw-redirect" title="SIGLEC">SIGLEC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">Sialoadhesin</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/Myelin-associated_glycoprotein" title="Myelin-associated glycoprotein">Myelin-associated glycoprotein</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">SIGLEC5</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">SIGLEC6</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">SIGLEC7</a></li> <li><a href="/wiki/SIGLEC8" title="SIGLEC8">SIGLEC8</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">SIGLEC9</a></li> <li><a href="/wiki/SIGLEC10" title="SIGLEC10">SIGLEC10</a></li> <li><a href="/wiki/SIGLEC12" class="mw-redirect" title="SIGLEC12">SIGLEC12</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/Calreticulin" title="Calreticulin">Calreticulin</a></li> <li><a href="/wiki/Galectin" title="Galectin">Galectin</a></li> <li><a href="/wiki/N-Acetylglucosamine_receptor" title="N-Acetylglucosamine receptor">N-Acetylglucosamine receptor</a></li> <li><a href="/wiki/Selectin" title="Selectin">Selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Plant</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Toxalbumin" title="Toxalbumin">Toxalbumins</a> <ul><li><a href="/wiki/Abrin" title="Abrin">Abrin</a></li> <li><a href="/wiki/Ricin" title="Ricin">Ricin</a></li></ul></li> <li><a href="/wiki/Mitogen" title="Mitogen">Mitogens</a> <ul><li><a href="/wiki/Concanavalin_A" title="Concanavalin A">Concanavalin A</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Pokeweed_mitogen" title="Pokeweed mitogen">Pokeweed mitogen</a></li></ul></li> <li><a href="/wiki/Legume_lectin" title="Legume lectin">Legume lectin</a></li> <li><a href="/wiki/BanLec" title="BanLec">BanLec</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Protein,_glycoconjugate:_glycoproteins_and_glycopeptides" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Glycoproteins" title="Template:Glycoproteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Glycoproteins" title="Template talk:Glycoproteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Glycoproteins" title="Special:EditPage/Template:Glycoproteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein,_glycoconjugate:_glycoproteins_and_glycopeptides" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Protein</a>, <a href="/wiki/Glycoconjugate" title="Glycoconjugate">glycoconjugate</a>: <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoproteins</a> and <a href="/wiki/Glycopeptide" title="Glycopeptide">glycopeptides</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucoprotein" title="Mucoprotein">Mucoproteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Mucin" title="Mucin">Mucin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">MUC1</a></li> <li><a href="/wiki/MUC2" class="mw-redirect" title="MUC2">MUC2</a></li> <li><a href="/wiki/MUC3A" class="mw-redirect" title="MUC3A">MUC3A</a></li> <li><a href="/wiki/MUC3B" class="mw-redirect" title="MUC3B">MUC3B</a></li> <li><a href="/wiki/MUC4" class="mw-redirect" title="MUC4">MUC4</a></li> <li><a href="/wiki/MUC5AC" class="mw-redirect" title="MUC5AC">MUC5AC</a></li> <li><a href="/wiki/MUC5B" class="mw-redirect" title="MUC5B">MUC5B</a></li> <li><a href="/wiki/MUC6" class="mw-redirect" title="MUC6">MUC6</a></li> <li><a href="/wiki/MUC7" class="mw-redirect" title="MUC7">MUC7</a></li> <li><a href="/wiki/MUC8" class="mw-redirect" title="MUC8">MUC8</a></li> <li><a href="/wiki/Mucin" title="Mucin">MUC12</a></li> <li><a href="/wiki/MUC13" class="mw-redirect" title="MUC13">MUC13</a></li> <li><a href="/wiki/MUC15" class="mw-redirect" title="MUC15">MUC15</a></li> <li><a href="/wiki/CA-125" class="mw-redirect" title="CA-125">MUC16</a></li> <li><a href="/wiki/MUC17" class="mw-redirect" title="MUC17">MUC17</a></li> <li><a href="/wiki/MUC19" class="mw-redirect" title="MUC19">MUC19</a></li> <li><a href="/wiki/MUC20" class="mw-redirect" title="MUC20">MUC20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Haptoglobin" title="Haptoglobin">Haptoglobin</a></li> <li><a href="/wiki/Intrinsic_factor" title="Intrinsic factor">Intrinsic factor</a></li> <li><a href="/wiki/Orosomucoid" title="Orosomucoid">Orosomucoid</a></li> <li><a href="/wiki/Peptidoglycan" title="Peptidoglycan">Peptidoglycan</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Ovomucin" title="Ovomucin">Ovomucin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Proteoglycan" title="Proteoglycan">Proteoglycans</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a>/<a href="/wiki/Dermatan_sulfate" title="Dermatan sulfate">DS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Biglycan" title="Biglycan">Biglycan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a>/<a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Testican" title="Testican">Testican</a></li> <li><a href="/wiki/Perlecan" title="Perlecan">Perlecan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chondroitin_sulfate" title="Chondroitin sulfate">CS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chondroitin_sulfate_proteoglycan" title="Chondroitin sulfate proteoglycan">Chondroitin sulfate proteoglycans</a>: <a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a class="mw-selflink selflink">Neurocan</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CSPG4" title="CSPG4">CSPG4</a></li> <li><a href="/wiki/CSPG5" title="CSPG5">CSPG5</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">Platelet factor 4</a></li> <li><a href="/wiki/SMC3_(gene)" class="mw-redirect" title="SMC3 (gene)">Structural maintenance of chromosomes 3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Keratan_sulfate" title="Keratan sulfate">KS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibromodulin" title="Fibromodulin">Fibromodulin</a></li> <li><a href="/wiki/Lumican" title="Lumican">Lumican</a></li> <li><a href="/wiki/Keratocan" title="Keratocan">Keratocan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Heparan_sulfate" title="Heparan sulfate">HS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Syndecan_1" title="Syndecan 1">Syndecan 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a></li> <li><a href="/wiki/A_disintegrin_and_metalloproteinase" class="mw-redirect" title="A disintegrin and metalloproteinase">ADAM</a></li> <li><a href="/wiki/Alpha_1-antichymotrypsin" title="Alpha 1-antichymotrypsin">Alpha 1-antichymotrypsin</a></li> <li><a href="/wiki/Apolipoprotein_H" title="Apolipoprotein H">Apolipoprotein H</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/Asialoglycoprotein" title="Asialoglycoprotein">Asialoglycoprotein</a></li> <li><a href="/wiki/Avidin" title="Avidin">Avidin</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">B-cell activating factor</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">4-1BB ligand</a></li> <li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">Cholesterylester transfer protein</a></li> <li><a href="/wiki/Clusterin" title="Clusterin">Clusterin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li> <li><a href="/wiki/Hemopexin" title="Hemopexin">Hemopexin</a></li> <li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a></li> <li><a href="/wiki/Membrane_glycoproteins" title="Membrane glycoproteins">Membrane glycoproteins</a></li> <li><a href="/wiki/Myelin_protein_zero" title="Myelin protein zero">Myelin protein zero</a></li> <li><a href="/wiki/Osteonectin" title="Osteonectin">Osteonectin</a></li> <li><a href="/wiki/Protein_C" title="Protein C">Protein C</a></li> <li><a href="/wiki/Protein_S" title="Protein S">Protein S</a></li> <li><a href="/wiki/Serum_amyloid_P_component" title="Serum amyloid P component">Serum amyloid P component</a></li> <li><a href="/wiki/Sialoglycoprotein" title="Sialoglycoprotein">Sialoglycoprotein</a> <ul><li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/Glycophorin" title="Glycophorin">Glycophorin</a></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">Glycophorin C</a></li></ul></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a></li> <li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Thyroxine-binding_proteins" title="Thyroxine-binding proteins">Thyroxine-binding proteins</a></li> <li><a href="/wiki/Transcortin" title="Transcortin">Transcortin</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">Tumor necrosis factor alpha</a></li> <li><a href="/wiki/Uteroglobin" title="Uteroglobin">Uteroglobin</a></li> <li><a href="/wiki/Vitronectin" title="Vitronectin">Vitronectin</a></li></ul> </div></td></tr></tbody></table></div> <p><br /> </p> <style data-mw-deduplicate="TemplateStyles:r1012311289">.mw-parser-output .asbox{position:relative;overflow:hidden}.mw-parser-output .asbox 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