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Synthesis of 3,4-Dihydro-1H-Quinoxalin-2-Ones and 1H鈥慟uinolin-2-Ones and Evaluation of Their Anti-Bacterial Activity
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/></div></noscript> <!-- /Yandex.Metrika counter --> <!-- Matomo --> <!-- End Matomo Code --> <title>Synthesis of 3,4-Dihydro-1H-Quinoxalin-2-Ones and 1H鈥慟uinolin-2-Ones and Evaluation of Their Anti-Bacterial Activity</title> <meta name="description" content="Synthesis of 3,4-Dihydro-1H-Quinoxalin-2-Ones and 1H鈥慟uinolin-2-Ones and Evaluation of Their Anti-Bacterial Activity"> <meta name="keywords" content="quinolin, quinoxalin, anti-bacterial activity, minimum inhibitory concentration (MIC)"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link 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class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 87412</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Synthesis of 3,4-Dihydro-1H-Quinoxalin-2-Ones and 1H鈥慟uinolin-2-Ones and Evaluation of Their Anti-Bacterial Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Amiri">Ali Amiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Arash%20Esfandiari"> Arash Esfandiari</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Zarenezhad"> Elham Zarenezhad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We report here an efficient and rapid method for the preparation of 3,4-dihydro-1H-quinoxalin-2-ones and 1H鈥憅uinolin-2-ones that involves grinding of o-, m-, or p鈥憄henylenediamine and three dialkyl acetylenedicarboxylates using a pestle and mortar. This solvent-free approach requires only a few minutes of reaction time. This type of reaction is expected to be the most economical method since neither catalyst nor solvent is used. Finally, all synthesised compounds were screened for antimicrobial activity against two Gram-positive bacteria (Pseudomonas aeruginosa PTCC 1077, Escherichia coli PTCC1330) and two Gram-negative bacteria (Staphylococcus aureus PTCC 1133, Bacillus cereus PTCC 1015) and their activity. Compared with gentamycin and ampicillin as reference drugs for Gram-negative and Gram-positive bacteria, respectively. The minimum inhibitory concentration (MIC) of the synthesised compounds and reference drugs were determined by the microdilution method. Good antibacterial activity was observed for 3,4-dihydro-1H-quinoxalin-2-ones against all species of Gram-positive and Gram-negative bacteria, and1H鈥憅uinolin-2-ones showed good antibacterial activity against two Gram-positive bacteria. <iframe src="https://publications.waset.org/abstracts/38704.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=quinolin" title="quinolin">quinolin</a>, <a href="https://publications.waset.org/abstracts/search?q=quinoxalin" title=" quinoxalin"> quinoxalin</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-bacterial%20activity" title=" anti-bacterial activity"> anti-bacterial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=minimum%20inhibitory%20concentration%20%28MIC%29" title=" minimum inhibitory concentration (MIC)"> minimum inhibitory concentration (MIC)</a> </p> <a href="https://publications.waset.org/abstracts/38704/synthesis-of-34-dihydro-1h-quinoxalin-2-ones-and-1hquinolin-2-ones-and-evaluation-of-their-anti-bacterial-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38704.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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