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Spectrometry</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-17908 post type-post status-publish format-standard has-post-thumbnail category-clinical-research-and-toxicology category-mass-spectrometry tag-mass-spectrometry tag-paperspray-ms tag-ps-ms entry" aria-label="Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening"><header class="entry-header"><h1 class="entry-title">Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/analyteguru/tf-author/courtney-patterson/" title="Posts by Courtney Patterson" rel="author">Courtney Patterson, Application Scientist, LC-MS, Thermo Fisher Scientific</a> </span> <span class="post-info-date"> 07.11.2024 </span> </header><div class="entry-content"> <h3 class="wp-block-heading" id="h-expedited-screening-improves-outcomes-for-individuals-with-drug-toxicity"><strong>Expedited screening improves outcomes for individuals with drug toxicity</strong></h3> <p>In the field of clinical research and toxicology, the detection and quantification of drugs in human samples with suspected drug overdose or acute drug toxicity are critical. This blog post explores the potential of paper spray mass spectrometry (PS-MS) such as <a href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html" target="_blank" rel="noreferrer noopener">Thermo Scientific VeriSpray PaperSpray ion source</a>, for faster and more efficient drug toxicity screening in emergency room applications.</p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="683" src="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity-1024x683.jpg" alt="" class="wp-image-17909" srcset="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity-1024x683.jpg 1024w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity-300x200.jpg 300w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity-768x512.jpg 768w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity-96x65.jpg 96w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2024/07/Drug-toxicity.jpg 1200w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <p>Researchers from <a href="https://www.kcl.ac.uk/forensics" target="_blank" rel="noreferrer noopener">King’s College London</a> (KCL) are collaborating with Guy’s and St Thomas’ NHS Foundation Trust and leveraging the capabilities of paper spray-mass spectrometry (PS-MS) to analyze blood samples from individuals with acute drug toxicity in the emergency room. The aim is to develop routine methods for detecting and quantifying drugs, ultimately improving health outcomes for individuals in need of immediate care and making drug toxicity screening at the bedside a possibility in the future.</p> <p>KCL researchers are conducting extensive testing and optimization of PS-MS technology. Preliminary results shared at The International Association of Forensic Toxicologists (TIAFT) 2023 annual meeting in Rome have shown promising linearity across various concentrations for a number of cathinones. The goal is to refine the process and enhance accuracy, with the potential implementation of PS-MS into clinical practice.</p> <h3 class="wp-block-heading" id="h-advantages-of-verispray-paperspray-mass-spectrometry"><strong>Advantages of VeriSpray PaperSpray mass spectrometry</strong></h3> <p>PS-MS with the <a href="https://www.thermofisher.com/order/catalog/product/TSQ03-10002" target="_blank" rel="noreferrer noopener">Thermo Scientific™ TSQ Altis™ Plus Triple Quadrupole</a> mass spectrometer offers several advantages over traditional orthogonal techniques. It enables rapid analysis, eliminating the need for lengthy sample preparation and chromatography-based separation. Additionally, the technique provides quantitative or screening results, is easy to use, reduces the risk of cross-contamination, and has barcoded tracking for LIMS compatibility with robotic automated systems such as Hamilton. Plus, it minimizes the use of chemicals and solvents, making it more environmentally friendly.</p> <p>PS-MS offers a fast (2 minutes or less) turnaround time for high-throughput screening, enabling quick analysis of single samples from individuals and identify the presence of drugs or substances. The system’s ease of use and ability to process 240 samples unattended make it efficient and time-saving. The aim is to make drug toxicity screening at the bedside a reality, reducing waiting times for results and improving overall care.</p> <h3 class="wp-block-heading" id="h-great-potential-for-poc-toxicity-screening"><strong>Great potential for POC toxicity screening</strong></h3> <p>The collaboration between KCL, Guy’s and St Thomas’ NHS Foundation Trust, and research on PS-MS holds great potential for improving point-of-care drug toxicity screening. PS-MS offers a rapid, efficient, and accurate alternative to traditional methods, enabling faster and more efficient care for individuals presenting with acute drug toxicity. By implementing this technology, hospitals can reduce waiting times and ultimately improve outcomes in emergency settings. To learn more, <a href="https://www.linkedin.com/posts/ema-ru%C5%BEi%C4%87-5ba70b133_paper-spray-mass-spectrometry-simplifies-activity-7196531937463750656-0FgR?utm_source=share&utm_medium=member_desktop">download the recent case study</a>.</p> <h3 class="wp-block-heading" id="h-related-information"><strong>Related information</strong></h3> <ol class="wp-block-list"> <li><a href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html" target="_blank" rel="noreferrer noopener">Thermofisher.com/verispray</a></li> <li><a href="https://pubmed.ncbi.nlm.nih.gov/36193928/#:~:text=Intentional%20and%20accidental%20drug%20overdose,morbidity%20and%20prolonged%20hospital%20admissions." target="_blank" rel="noreferrer noopener">Toxicology in the emergency department: what’s new?</a></li> <li><a href="https://www.kcl.ac.uk/news/thermo-fisher-scientific-collaboration-offers-potential-for-faster-more-efficient-analysis-of-samples-from-drug-toxicity-patients" target="_blank" rel="noreferrer noopener">Thermo Fisher Scientific collaboration offers potential for faster, more efficient analysis of samples from drug toxicity patients</a></li> <li><a href="https://view.highspot.com/viewer/6644c7d165ad350931b0517c" target="_blank" rel="noreferrer noopener">Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening: Thermo Fisher Scientific Case Study</a></li> </ol> </div></article><section class="author-box"><h4 class="author-box-title">Courtney Patterson</h4><div class="author-box-content" itemprop="description">Courtney Patterson is an Application Scientist at Thermo Fisher Scientific, specializing in the development of LC-MS applications for forensic and clinical toxicology using targeted and untargeted approaches to quantify and confirm drugs of abuse.</div></section><div class="adjacent-entry-pagination pagination"><div class="pagination-previous alignleft"><i class="fa fa-icon fa-chevron-left"></i> <a href="https://www.thermofisher.com/blog/analyteguru/why-you-need-a-verification-class-mass-spectrometer/" rel="prev">Why You Need a Verification-class Mass Spectrometer</a></div><div class="pagination-next alignright"><a href="https://www.thermofisher.com/blog/analyteguru/the-vital-role-of-ic-in-ensuring-water-quality/" rel="next">The Vital Role of IC in Ensuring Water Quality</a> <i class="fa fa-icon fa-chevron-right"></i></div></div></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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