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donazione</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:CreaUtenza&returnto=Idrossiprolina" title="Si consiglia di registrarsi e di effettuare l'accesso, anche se non è obbligatorio" class=""><span>registrati</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:Entra&returnto=Idrossiprolina" title="Si consiglia di effettuare l'accesso, anche se non è obbligatorio [o]" accesskey="o" class=""><span>entra</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Altre opzioni" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" 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class="vector-menu-heading"> Pagine per utenti anonimi <a href="/wiki/Aiuto:Benvenuto" aria-label="Ulteriori informazioni sulla contribuzione"><span>ulteriori informazioni</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speciale:MieiContributi" title="Un elenco delle modifiche fatte da questo indirizzo IP [y]" accesskey="y"><span>contributi</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speciale:MieDiscussioni" title="Discussioni sulle modifiche fatte da questo indirizzo IP [n]" accesskey="n"><span>discussioni</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" 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class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Note"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Note</span> </div> </a> <ul id="toc-Note-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bibliografia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografia"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Bibliografia</span> </div> </a> <ul id="toc-Bibliografia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voci_correlate" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voci_correlate"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Voci correlate</span> </div> </a> <ul id="toc-Voci_correlate-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Collegamenti_esterni" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Collegamenti_esterni"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Collegamenti esterni</span> </div> </a> <ul id="toc-Collegamenti_esterni-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Idrossiprolina</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 21 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-21" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">21 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%DB%8C%D8%AF%D8%B1%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%D9%BE%D8%B1%D9%88%D9%84%DB%8C%D9%86" title="هیدروکسی‌پرولین - South Azerbaijani" lang="azb" hreflang="azb" data-title="هیدروکسی‌پرولین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Hidroxiprolina" title="Hidroxiprolina - catalano" lang="ca" hreflang="ca" data-title="Hidroxiprolina" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Hydroxyprolin" title="Hydroxyprolin - tedesco" lang="de" hreflang="de" data-title="Hydroxyprolin" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A5%CE%B4%CF%81%CE%BF%CE%BE%CF%85%CF%80%CF%81%CE%BF%CE%BB%CE%AF%CE%BD%CE%B7" title="Υδροξυπρολίνη - greco" lang="el" hreflang="el" data-title="Υδροξυπρολίνη" data-language-autonym="Ελληνικά" data-language-local-name="greco" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Hydroxyproline" title="Hydroxyproline - inglese" lang="en" hreflang="en" data-title="Hydroxyproline" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Hidroxiprolina" title="Hidroxiprolina - spagnolo" lang="es" hreflang="es" data-title="Hidroxiprolina" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%DB%8C%D8%AF%D8%B1%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%D9%BE%D8%B1%D9%88%D9%84%DB%8C%D9%86" title="هیدروکسی‌پرولین - persiano" lang="fa" hreflang="fa" data-title="هیدروکسی‌پرولین" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi badge-Q17559452 badge-recommendedarticle mw-list-item" title="voce consigliata"><a href="https://fi.wikipedia.org/wiki/Hydroksiproliini" title="Hydroksiproliini - finlandese" lang="fi" hreflang="fi" data-title="Hydroksiproliini" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Hydroxyproline" title="Hydroxyproline - francese" lang="fr" hreflang="fr" data-title="Hydroxyproline" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Hidroxiprolina" title="Hidroxiprolina - galiziano" lang="gl" hreflang="gl" data-title="Hidroxiprolina" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B9%E0%A4%BE%E0%A4%87%E0%A4%A1%E0%A5%8D%E0%A4%B0%E0%A5%89%E0%A4%95%E0%A5%8D%E0%A4%B8%E0%A4%BF%E0%A4%AA%E0%A5%8D%E0%A4%B0%E0%A5%8B%E0%A4%B2%E0%A4%BF%E0%A4%A8" title="हाइड्रॉक्सिप्रोलिन - hindi" lang="hi" hreflang="hi" data-title="हाइड्रॉक्सिप्रोलिन" data-language-autonym="हिन्दी" data-language-local-name="hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%92%E3%83%89%E3%83%AD%E3%82%AD%E3%82%B7%E3%83%97%E3%83%AD%E3%83%AA%E3%83%B3" title="ヒドロキシプロリン - giapponese" lang="ja" hreflang="ja" data-title="ヒドロキシプロリン" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%95%98%EC%9D%B4%EB%93%9C%EB%A1%9D%EC%8B%9C%ED%94%84%EB%A1%A4%EB%A6%B0" title="하이드록시프롤린 - coreano" lang="ko" hreflang="ko" data-title="하이드록시프롤린" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Hydroxyproline" title="Hydroxyproline - olandese" lang="nl" hreflang="nl" data-title="Hydroxyproline" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Hydroksyprolina" title="Hydroksyprolina - polacco" lang="pl" hreflang="pl" data-title="Hydroksyprolina" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Hidroxiprolina" title="Hidroxiprolina - portoghese" lang="pt" hreflang="pt" data-title="Hidroxiprolina" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B8%D0%B4%D1%80%D0%BE%D0%BA%D1%81%D0%B8%D0%BF%D1%80%D0%BE%D0%BB%D0%B8%D0%BD" title="Гидроксипролин - russo" lang="ru" hreflang="ru" data-title="Гидроксипролин" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Hidroksiprolin" title="Hidroksiprolin - serbo-croato" lang="sh" hreflang="sh" data-title="Hidroksiprolin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Hidroksiprolin" title="Hidroksiprolin - serbo" lang="sr" hreflang="sr" data-title="Hidroksiprolin" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D1%96%D0%B4%D1%80%D0%BE%D0%BA%D1%81%D0%B8%D0%BF%D1%80%D0%BE%D0%BB%D1%96%D0%BD" title="Гідроксипролін - ucraino" lang="uk" hreflang="uk" data-title="Гідроксипролін" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%BE%9F%E8%84%AF%E8%83%BA%E9%85%B8" title="羟脯胺酸 - cinese" lang="zh" hreflang="zh" data-title="羟脯胺酸" data-language-autonym="中文" data-language-local-name="cinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q12460151#sitelinks-wikipedia" title="Modifica collegamenti interlinguistici" class="wbc-editpage">Modifica collegamenti</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespace"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Idrossiprolina" title="Vedi la voce [c]" accesskey="c"><span>Voce</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Discussione:Idrossiprolina&action=edit&redlink=1" rel="discussion" class="new" title="Vedi le discussioni relative a questa pagina (la pagina non esiste) [t]" accesskey="t"><span>Discussione</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Cambia versione linguistica" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">italiano</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Visite"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Idrossiprolina"><span>Leggi</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Idrossiprolina&veaction=edit" title="Modifica questa pagina [v]" accesskey="v"><span>Modifica</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Idrossiprolina&action=edit" title="Modifica il wikitesto di questa pagina [e]" accesskey="e"><span>Modifica wikitesto</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Idrossiprolina&action=history" title="Versioni precedenti di questa pagina [h]" accesskey="h"><span>Cronologia</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Strumenti" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Strumenti</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Strumenti</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">nascondi</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Altre opzioni" > <div class="vector-menu-heading"> Azioni </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Idrossiprolina"><span>Leggi</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Idrossiprolina&veaction=edit" title="Modifica questa pagina [v]" accesskey="v"><span>Modifica</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Idrossiprolina&action=edit" title="Modifica il wikitesto di questa pagina [e]" accesskey="e"><span>Modifica wikitesto</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Idrossiprolina&action=history"><span>Cronologia</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Generale </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Speciale:PuntanoQui/Idrossiprolina" title="Elenco di tutte le pagine che sono collegate a questa [j]" accesskey="j"><span>Puntano qui</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Speciale:ModificheCorrelate/Idrossiprolina" rel="nofollow" title="Elenco delle ultime modifiche alle pagine collegate a questa [k]" accesskey="k"><span>Modifiche correlate</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Speciale:PagineSpeciali" title="Elenco di tutte le pagine speciali [q]" accesskey="q"><span>Pagine speciali</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Idrossiprolina&oldid=141409500" title="Collegamento permanente a questa versione di questa pagina"><span>Link permanente</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Idrossiprolina&action=info" title="Ulteriori informazioni su questa pagina"><span>Informazioni pagina</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Speciale:Cita&page=Idrossiprolina&id=141409500&wpFormIdentifier=titleform" title="Informazioni su come citare questa pagina"><span>Cita questa voce</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Speciale:UrlShortener&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FIdrossiprolina"><span>Ottieni URL breve</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Speciale:QrCode&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FIdrossiprolina"><span>Scarica codice QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Stampa/esporta </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speciale:Libro&bookcmd=book_creator&referer=Idrossiprolina"><span>Crea un libro</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Speciale:DownloadAsPdf&page=Idrossiprolina&action=show-download-screen"><span>Scarica come PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Idrossiprolina&printable=yes" title="Versione stampabile di questa pagina [p]" accesskey="p"><span>Versione stampabile</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In altri progetti </div> <div 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id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="it" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r133964453">.mw-parser-output .avviso .mbox-text-div>div,.mw-parser-output .avviso .mbox-text-full-div>div{font-size:90%}.mw-parser-output .avviso .mbox-image{flex-basis:52px;flex-grow:0;flex-shrink:0}.mw-parser-output .avviso .mbox-text-full-div .hide-when-compact{display:block}</style><div style="" class="ambox metadata noprint plainlinks avviso avviso-generico"> <div class="avviso-immagine mbox-image noprint"><span typeof="mw:File"><a href="/wiki/File:Biochemistry_icon.png" class="mw-file-description" title="Abbozzo biochimica"><img alt="Abbozzo biochimica" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Biochemistry_icon.png/45px-Biochemistry_icon.png" decoding="async" width="45" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Biochemistry_icon.png/68px-Biochemistry_icon.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Biochemistry_icon.png/90px-Biochemistry_icon.png 2x" data-file-width="128" data-file-height="128" /></a></span></div> <div class="avviso-testo mbox-text"> <div class="mbox-text-div"><b>Questa voce  sull'argomento biochimica è solo un <a href="/wiki/Aiuto:Abbozzo" title="Aiuto:Abbozzo">abbozzo</a></b>.<br /> <div style="font-size:90%;"><a class="external text" href="https://it.wikipedia.org/w/index.php?title=Idrossiprolina&action=edit">Contribuisci</a> a migliorarla secondo le <a href="/wiki/Aiuto:Manuale_di_stile" title="Aiuto:Manuale di stile">convenzioni di Wikipedia</a>. Segui i suggerimenti del <a href="/wiki/Progetto:Biochimica" class="mw-redirect" title="Progetto:Biochimica">progetto di riferimento</a>.</div> <div class="hide-when-compact"> </div> </div> </div> </div> <table class="infobox sinottico" summary="Tabella sinottica che riassume i principali dati del soggetto" style="width:300px;"><tbody><tr class="sinottico_testata"><th colspan="2" style="background-color:#AADDFF;">Idrossiprolina</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><figure class="mw-halign-center" typeof="mw:File/Frameless"><a href="/wiki/File:Hydroxyproline_structure.svg" class="mw-file-description" title="Formula di Struttura"><img alt="Formula di Struttura" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Hydroxyproline_structure.svg/230px-Hydroxyproline_structure.svg.png" decoding="async" width="230" height="144" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Hydroxyproline_structure.svg/345px-Hydroxyproline_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Hydroxyproline_structure.svg/460px-Hydroxyproline_structure.svg.png 2x" data-file-width="560" data-file-height="350" /></a><figcaption>Formula di Struttura</figcaption></figure> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF;">Nome <a href="/wiki/Unione_internazionale_di_chimica_pura_e_applicata" title="Unione internazionale di chimica pura e applicata">IUPAC</a></th></tr><tr><td class="sinottico_testo_centrale" colspan="2">(2<i>S</i>,4<i>R</i>)-4-idrossipirrolidina-<br />2-carbossilato </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF;">Abbreviazioni</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><b>Hyp</b> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Caratteristiche generali</th></tr><tr><th><a href="/wiki/Formula_bruta" title="Formula bruta">Formula bruta</a> o <a href="/wiki/Formula_molecolare" title="Formula molecolare">molecolare</a></th><td>C<sub>5</sub>H<sub>9</sub>NO<sub>3</sub> </td></tr><tr><th><a href="/wiki/Massa_molecolare" title="Massa molecolare">Massa molecolare</a> (<a href="/wiki/Unit%C3%A0_di_massa_atomica" title="Unità di massa atomica">u</a>)</th><td>131.13 <a href="/wiki/Grammi" class="mw-redirect" title="Grammi">g</a>·<a href="/wiki/Mole" title="Mole">mol</a><sup>−1</sup> </td></tr><tr><th><a href="/wiki/Numero_CAS" title="Numero CAS">Numero CAS</a></th><td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="https://iw.toolforge.org/magnustools/cas.php?language=it&cas=51-35-4">51-35-4</a></span></span> </td></tr><tr><th><a href="/wiki/Numero_EINECS" title="Numero EINECS">Numero EINECS</a></th><td>200-091-9 </td></tr><tr><th><a href="/wiki/PubChem" title="PubChem">PubChem</a></th><td><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5810">5810</a> e <a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6971053">6971053</a> </td></tr><tr><th><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DBDB08847">DBDB08847</a> </td></tr><tr><th><a href="/wiki/SMILES" title="SMILES">SMILES</a></th><td><div style="word-break: break-all;"><code style="background-color:transparent; border:none">C1C(CNC1C(=O)O)O</code></div> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Indicazioni di sicurezza</th></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q12460151" class="extiw" title="d:Q12460151"><span title="Modifica i dati della voce Idrossiprolina su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Composto_chimico/man" title="Template:Composto chimico/man"><span title="Manuale del template Composto chimico">Manuale</span></a></td></tr></tbody></table> <p>L'<b>idrossiprolina</b> è un <a href="/wiki/Amminoacido" title="Amminoacido">amminoacido</a> non standard, componente del <a href="/wiki/Collagene" title="Collagene">collagene</a> (ne costituisce circa il 14%). Si trova quasi esclusivamente in questa <a href="/wiki/Proteina" class="mw-redirect" title="Proteina">proteina</a>. </p><p>Nel <a href="/wiki/Collagene" title="Collagene">collagene</a> <a href="/wiki/Ponti_idrogeno" class="mw-redirect" title="Ponti idrogeno">ponti idrogeno</a> tra i gruppi ossidrilici dell'idrossiprolina e dell'<a href="/w/index.php?title=Idrossilisina&action=edit&redlink=1" class="new" title="Idrossilisina (la pagina non esiste)">idrossilisina</a> stabilizzano la struttura. Tali ponti formano <b>legami crociati</b> inter-catene α (intra-tropocollagene) e interfibrille. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Struttura_e_scoperta">Struttura e scoperta</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=1" title="Modifica la sezione Struttura e scoperta" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=1" title="Edit section's source code: Struttura e scoperta"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nel 1902, <a href="/wiki/Hermann_Emil_Fischer" title="Hermann Emil Fischer">Hermann Emil Fischer</a> isolò l'idrossiprolina dalla gelatina idrolizzata. Nel 1905, Hermann Leuchs sintetizzò una miscela racemica di 4-idrossiprolina. </p><p>L'idrossiprolina si differenzia dalla <a href="/wiki/Prolina" title="Prolina">prolina</a> per la presenza di un gruppo ossidrile (-OH) attaccato all'atomo di carbonio γ. </p> <div class="mw-heading mw-heading2"><h2 id="Funzioni">Funzioni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=2" title="Modifica la sezione Funzioni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=2" title="Edit section's source code: Funzioni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Un livello elevato di idrossiprolina è osservato in diversi disturbi, come nella <a href="/wiki/Graft-versus-host_disease" title="Graft-versus-host disease">malattia del trapianto contro l'ospite</a>, nei <a href="/wiki/Cheloidi" class="mw-redirect" title="Cheloidi">cheloidi</a> e nella <a href="/wiki/Vitiligine" title="Vitiligine">vitiligine</a>. Al contrario il suo livello ridotto è un indicatore di scarsa guarigione delle ferite.<sup id="cite_ref-Kumar_Srivastava_Khare_Kumar_Nagar_Raghuwanshi_2016_pp._596–602_1-0" class="reference"><a href="#cite_note-Kumar_Srivastava_Khare_Kumar_Nagar_Raghuwanshi_2016_pp._596–602-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>L'idrossiprolina è comunemente riscontrabile nelle urine e la sua concentrazione è un indice del metabolismo del collagene. L'aumento dell'idrossiprolinuria si riscontra nelle patologie scheletriche e in particolare nell'<a href="/wiki/Osteoporosi" title="Osteoporosi">osteoporosi</a>.<sup id="cite_ref-Hasselbalch_2009_pp._447–451_2-0" class="reference"><a href="#cite_note-Hasselbalch_2009_pp._447–451-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>La sintesi intracellulare di idrossiprolina è correlata ai livelli di assorbimento dell'<a href="/wiki/Acido_ascorbico" title="Acido ascorbico">Acido ascorbico</a> (Vit. C).<sup id="cite_ref-Wolf_2009_pp._150–152_3-0" class="reference"><a href="#cite_note-Wolf_2009_pp._150–152-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Note">Note</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=3" title="Modifica la sezione Note" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=3" title="Edit section's source code: Note"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Kumar_Srivastava_Khare_Kumar_Nagar_Raghuwanshi_2016_pp._596–602-1"><a href="#cite_ref-Kumar_Srivastava_Khare_Kumar_Nagar_Raghuwanshi_2016_pp._596–602_1-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> Amit Kumar Srivastava, Piush Khare, Hemant Kumar Nagar, Navdeep Raghuwanshi e Rajnish Srivastava, <a rel="nofollow" class="external text" href="https://oadoi.org/10.2174/1389203717666151201192247"><span style="font-style:italic;">Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases</span></a>, in <span style="font-style:italic;">Current Protein & Peptide Science</span>, vol. 17, n. 6, Bentham Science Publishers Ltd., 15 luglio 2016, pp. 596–602, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.2174%2F1389203717666151201192247">10.2174/1389203717666151201192247</a>, <a href="/wiki/ISSN" title="ISSN">ISSN</a> 1389-2037<span class="noprint plainlinks"> (<span title="Ricerca su WorldCat"><a rel="nofollow" class="external text" href="http://worldcat.org/issn/1389-2037&lang=it">WC</a></span> · <span title="Ricerca sul Catalogo Italiano dei Periodici"><a rel="nofollow" class="external text" href="https://acnpsearch.unibo.it/search?issn=1389-2037">ACNP</a></span>)</span>.</cite></span> </li> <li id="cite_note-Hasselbalch_2009_pp._447–451-2"><a href="#cite_ref-Hasselbalch_2009_pp._447–451_2-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> Hans Hasselbalch, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1111/j.1600-0609.1987.tb01454.x"><span style="font-style:italic;">Urinary hydroxyproline excretion in the myelofibrosis-osteomyelosclerosis syndrome and related diseases</span></a>, in <span style="font-style:italic;">European Journal of Haematology</span>, vol. 39, n. 5, Wiley, 24 aprile 2009, pp. 447–451, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1111%2Fj.1600-0609.1987.tb01454.x">10.1111/j.1600-0609.1987.tb01454.x</a>, <a href="/wiki/ISSN" title="ISSN">ISSN</a> 0902-4441<span class="noprint plainlinks"> (<span title="Ricerca su WorldCat"><a rel="nofollow" class="external text" href="http://worldcat.org/issn/0902-4441&lang=it">WC</a></span> · <span title="Ricerca sul Catalogo Italiano dei Periodici"><a rel="nofollow" class="external text" href="https://acnpsearch.unibo.it/search?issn=0902-4441">ACNP</a></span>)</span>.</cite></span> </li> <li id="cite_note-Wolf_2009_pp._150–152-3"><a href="#cite_ref-Wolf_2009_pp._150–152_3-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> George Wolf, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1111/j.1753-4887.1996.tb03918.x"><span style="font-style:italic;">The Mechanism of Uptake of Ascorbic Acid into Osteoblasts and Leukocytes</span></a>, in <span style="font-style:italic;">Nutrition Reviews</span>, vol. 54, n. 5, Oxford University Press (OUP), 27 aprile 2009, pp. 150–152, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1111%2Fj.1753-4887.1996.tb03918.x">10.1111/j.1753-4887.1996.tb03918.x</a>, <a href="/wiki/ISSN" title="ISSN">ISSN</a> 0029-6643<span class="noprint plainlinks"> (<span title="Ricerca su WorldCat"><a rel="nofollow" class="external text" href="http://worldcat.org/issn/0029-6643&lang=it">WC</a></span> · <span title="Ricerca sul Catalogo Italiano dei Periodici"><a rel="nofollow" class="external text" href="https://acnpsearch.unibo.it/search?issn=0029-6643">ACNP</a></span>)</span>.</cite></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=4" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=4" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite class="citation pubblicazione" style="font-style:normal"> NEVILLE STONE e ALTON MEISTER, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1038/194555a0"><span style="font-style:italic;">Function of Ascorbic Acid in the Conversion of Proline to Collagen Hydroxyproline</span></a>, in <span style="font-style:italic;">Nature</span>, vol. 194, n. 4828, Springer Science and Business Media LLC, 1962, pp. 555–557, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038%2F194555a0">10.1038/194555a0</a>, <a href="/wiki/ISSN" title="ISSN">ISSN</a> 0028-0836<span class="noprint plainlinks"> (<span title="Ricerca su WorldCat"><a rel="nofollow" class="external text" href="http://worldcat.org/issn/0028-0836&lang=it">WC</a></span> · <span title="Ricerca sul Catalogo Italiano dei Periodici"><a rel="nofollow" class="external text" href="https://acnpsearch.unibo.it/search?issn=0028-0836">ACNP</a></span>)</span>.</cite></li> <li><cite class="citation pubblicazione" style="font-style:normal"> M. J. Barnes, <a rel="nofollow" class="external text" href="https://oadoi.org/10.1111/j.1749-6632.1975.tb29287.x"><span style="font-style:italic;">FUNCTION OF ASCORBIC ACID IN COLLAGEN METABOLISM</span></a>, in <span style="font-style:italic;">Annals of the New York Academy of Sciences</span>, vol. 258, 1 Second Confer, Wiley, 1975, pp. 264–277, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1111%2Fj.1749-6632.1975.tb29287.x">10.1111/j.1749-6632.1975.tb29287.x</a>, <a href="/wiki/ISSN" title="ISSN">ISSN</a> 0077-8923<span class="noprint plainlinks"> (<span title="Ricerca su WorldCat"><a rel="nofollow" class="external text" href="http://worldcat.org/issn/0077-8923&lang=it">WC</a></span> · <span title="Ricerca sul Catalogo Italiano dei Periodici"><a rel="nofollow" class="external text" href="https://acnpsearch.unibo.it/search?issn=0077-8923">ACNP</a></span>)</span>.</cite></li></ul> <div class="mw-heading mw-heading2"><h2 id="Voci_correlate">Voci correlate</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=5" title="Modifica la sezione Voci correlate" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=5" title="Edit section's source code: Voci correlate"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Oxaceprolo" title="Oxaceprolo">Oxaceprolo</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Collegamenti_esterni">Collegamenti esterni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Idrossiprolina&veaction=edit&section=6" title="Modifica la sezione Collegamenti esterni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Idrossiprolina&action=edit&section=6" title="Edit section's source code: Collegamenti esterni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li class="mw-empty-elt"></li> <li><cite id="CITEREFBritannica.com" class="citation web" style="font-style:normal">(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) <a rel="nofollow" class="external text" href="https://www.britannica.com/science/hydroxyproline"><span style="font-style:italic;">hydroxyproline</span></a>, su <span style="font-style:italic;"><a href="/wiki/Enciclopedia_Britannica" title="Enciclopedia Britannica">Enciclopedia Britannica</a></span>, Encyclopædia Britannica, Inc.</cite> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q12460151#P1417" title="Modifica su Wikidata"><img alt="Modifica su Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></li></ul> <div class="noprint" style="width:100%; 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