Chan Zuckerberg Biohub San Francisco

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src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/02/home-sf-hero-mobile.jpg" alt="" > <div class="container-1060 relative"> <div class="text-wrap" style="max-width: 70rem"> <h1 class="h0 FontColor--white">Chan <br>Zuckerberg <br>Biohub <br>San Francisco</h1> </div> </div> </section>  <section class="locationsHome__intro relative"> <div class="container-1060 relative"> <figure class="locationsHome__intro-logo"> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2024/01/SF.png" alt="logos" > </figure> <div class="text-wrap"> <p>We bring together skilled and creative scientists and engineers to develop new technologies and tackle ambitious research projects, with the aim of understanding dynamic cell systems across scales in both healthy and diseased states.</p> <p>We also join forces with the Bay Area’s leading academic institutions to support bold, visionary science that can’t be done elsewhere.</p> <p>CZ Biohub San Francisco is part of the CZ Biohub Network, a group of nonprofit research institutes created and supported by the <span class="nowrap"><a href="https://chanzuckerberg.com/" target="_blank" rel="noopener">Chan Zuckerberg Initiative</a>.</span></p> </div> </div> </section>   <section class="locationsHome__comboMod"> <div class="locationsHome__comboMod__bg"> <img class="desktop" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-bg.png" alt=""> <img class="mobile" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-bg-mob.png" alt=""> <img class="largeScreen" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/10/sf-bg-large.png" alt=""> </div> <div class="locationsHome__comboMod-wrap"> <div class="container-1060"> <div class="videoBlock"> <div class="videoBlock__wrap flex"> <div class="videoBlock__left"> <figure class='hasCaption'> <video width="100%" height="auto" autoplay muted loop playsinline poster="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-vb1.jpeg"> <source src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/10/cell-division.mp4" type="video/mp4"> </video> <div class="new-caption"> Cell division visualized by label-free imaging </div> </figure> <div class="videoBlock__left-bottom flex"> <figure class='hasCaption'> <video width="100%" height="auto" autoplay muted loop playsinline poster="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-vb2.png"> <source src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/10/zebrafish.webm" type="video/webm"> </video> <div class="new-caption"> Light-sheet microscopy of zebrafish development </div> </figure> <figure class='hasCaption'> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-vb3.jpeg" alt="Two researchers building the Remoscope, a malaria diagnostic tool"> <div class="new-caption"> Building the Remoscope, a malaria diagnostic tool </div> </figure> </div> </div> <div class="videoBlock__right"> <h2 class="h3">Cells & Cell Systems</h2> <p>Cells are the fundamental unit of life. Our goal is to understand dynamic cell systems across scales, in both healthy and diseased states.</p> <figure class="videoBlock__right-desktopImg relative"> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-vb4.png" alt="UMAP depicting human cell types in the Tabula Sapiens"> <div class="new-caption under"> UMAP depicting human cell types in the Tabula Sapiens </div> </figure> <div class="videoBlock__mobileGrid flex wrap"> <figure class=''> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sfh-cells1-mob.jpeg" alt="Two researchers building the Remoscope, a malaria diagnostic tool"> </figure> <figure class=''> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sfh-cells2-mob.jpeg" alt="Light-sheet microscopy of zebrafish development"> </figure> <figure class='hasCaption'> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sfh-cells3-mob.jpeg" alt="Cell division visualized by QLIPP label-free imaging"> <div class="new-caption"> Cell division visualized by QLIPP label-free imaging </div> </figure> <figure class='hasCaption'> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sfh-cells4-mob.jpeg" alt="UMAP depicting human cell types in the Tabula Sapiens"> <div class="new-caption"> UMAP depicting human cell types in the Tabula Sapiens </div> </figure> </div> </div> </div> </div> <div class="zContent"> <div class="zContent__block two-imgs flex"> <div class="two-imgs-wrap flex"> <figure> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-dynamic-small.png" alt=""> </figure> <figure> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/sf-home-dynamic-lg.png" alt=""> </figure> </div> <div class="zContent__block-copy"> <h3>Dynamic … </h3> <p>We invent and apply state-of-the-art imaging technologies in living cells and organisms, and develop the computational tools to mechanistically interpret intracellular and intercellular behaviors.</p> </div> </div> <div class="zContent__block video flex"> <div class="video-wrap">  <video width="100%" height="auto" preload="none" autoplay muted loop playsinline poster="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/fish-poster.png"> <source src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/cropped-fish-1.mp4" type="video/mp4"> </video> </div> <div class="zContent__block-copy"> <h3>across scales …</h3> <p>Our <a class="tooltip" href="/sf/research-groups/">Research Groups</a> explore cell systems at various scales, from molecules (metabolites, proteins, transcripts), to cells, tissues, organs, and whole organisms, to define cell types, states, and disease phenotypes.</p> <p>At the grandest scale — in human populations — we enable pathogen surveillance and <a href="/rapid-response/">rapid outbreak response</a>. In collaboration with experts at our partner institutions, both domestically and in low- and middle-income countries, we work to understand infectious disease and advance public health.</p> </div> </div> <div class="zContent__block one-img flex"> <figure> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/09/healthndisease.png" alt=""> </figure> <div class="zContent__block-copy"> <h3>in health and disease</h3> <p>We map dynamic changes in cell behavior in response to disease and infection to define underlying mechanisms and to identify potential targets for therapeutic intervention and diagnostic tools.</p> <p>And our <a href="/sf/technology-platforms/">Technology Platforms</a> disseminate the technologies we develop — and the knowledge gained — world-wide through open-access publication and data portals.</p> </div> </div> </div> <div class="locationsHome__comboMod__cta"> <a class="btn" href="/sf/our-work">How we do it</a> </div> </div> </div> </section>  <section class="locationsHome__program"> <div class="locationsHome__program-container"> <div class="locationsHome__program-content"> <p class="overline">INVESTIGATOR PROGRAM</p> <h3>Building community to catalyze innovation</h3> <p>The Investigator Program at CZ Biohub SF is funding research by world-renowned scientists, engineers, and technologists from Stanford University, UC Berkeley, and UCSF.</p> <a class="btn" href="/sf/investigator-program/">Learn More</a> </div> <figure class="locationsHome__program-img"> <img src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/10/investigators-biohub.webp" alt="Investigators at CZ Biohub"> </figure> </div> </section>   <section class="locationsHome__leadership"> <div class="container-1060 relative"> <div class="locationsHome__sec-title"> <h2 class="eye--xl text-uppercase"> LEADERSHIP </h2> </div> <div class="locationsHome__leadership-wrap"> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/sf/people/leadership/joe-derisi-phd/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/02/joe_derisi.webp?w=761" alt="Joe DeRisi, Ph.D." > </figure> <h3 class="eye--m text-uppercase">Joe DeRisi, Ph.D.</h3> <p class="p--xs FontColor--gray-300">President</p> </a> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/sf/people/leadership/sandra-schmid-phd/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2021/04/sandra_schmidt.webp?w=761" alt="Sandra Schmid, Ph.D." > </figure> <h3 class="eye--m text-uppercase">Sandra Schmid, Ph.D.</h3> <p class="p--xs FontColor--gray-300">Chief Scientific Officer</p> </a> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/sf/people/leadership/rafael-gomez-sjoberg-phd/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2023/02/rafael_g_mez_sj_berg.webp?w=764" alt="Rafael Gómez-Sjöberg, Ph.D." > </figure> <h3 class="eye--m text-uppercase">Rafael Gómez-Sjöberg, Ph.D.</h3> <p class="p--xs FontColor--gray-300">Chief Technology Officer</p> </a> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/sf/people/leadership/melinda-griffith/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2022/05/melinda_griffth.webp?w=760" alt="Melinda Griffith" > </figure> <h3 class="eye--m text-uppercase">Melinda Griffith</h3> <p class="p--xs FontColor--gray-300">Chief Operating Officer; Chief Counsel</p> </a> </div> <a class="locationsHome__leadership-cta eye--m text-uppercase" href="/sf/people/#leadership" target="" > <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> View our complete leadership team </a> </div> </section>   <section class="locationsHome--blog"> <div class="container-1060 relative"> <section class="hub-logo"> <div class="hub-logo__container"> <a href="https://www.czbiohub.org/sf" aria-label="Life and Science stories from CZ Biohub"> <svg width="274" height="74" viewBox="0 0 274 74" fill="none" xmlns="http://www.w3.org/2000/svg"> <path class="top-logo" d="M12.6845 34.9999H0.988469V33.4519C1.93447 33.4519 2.62247 33.3659 3.05247 33.1939C3.51114 32.9932 3.7978 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stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> <a href="https://www.czbiohub.org/life-science/riddle-of-the-sphinx/" > <div class="news-card"> <div class="news-card__img "> <div class="cata-top cat-top"> <span class="category">Our People</span> </div> <img class="" src="https://www.czbiohub.org/wp-content/uploads/2024/03/sphinx-feat.png?w=960" alt=""> </div> <div class="news-card__content"> <h5 class="p--strong">Riddle of the sphinx</h5> <p>Probing the sphinx tile to explore geometry and chirality in ...</p> <div class="news-card__cta eye--s text-uppercase"> <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> <a href="https://www.czbiohub.org/life-science/mind-blowing-science-star-wars-style-holograms-to-communicate-with-the-brain/" > <div class="news-card"> <div class="news-card__img "> <div class="cata-top cat-top"> <span class="category">Biohub Investigators</span> </div> <img class="" src="https://www.czbiohub.org/wp-content/uploads/2024/03/20240109_Muller-Waller-Adesnik-1000px.jpg?w=960" alt=""> </div> <div class="news-card__content"> <h5 class="p--strong">Mind-blowing science: ‘Star Wars-style’ holograms to communicate with the brain</h5> <p>About 20 years ago, neuroscientists, recording from electrodes implanted in the medial temporal lobe, identified human brain cells that respond only to photos ...</p> <div class="news-card__cta eye--s text-uppercase"> <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> </section> </div> </section>  <section class="locationsHome__research"> <div class="container"> <div class="locationsHome__research-content"> <h2 class="h4">Our Research</h2> <p>CZ Biohub San Francisco produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. Explore a selection of publications and preprints from across our institutes and grant partners.</p> <a class="btn" href="https://chanzuckerberg.com/science/research/?affiliations=czb-sf#science-research" target="_blank">Learn More</a> </div> <figure class="locationsHome__research-image"> <img class="desktop-only" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2024/11/sf-research.webp" alt="Shots of CZ Biohub SF doing research in three bubbles"> <img class="mobile-only" src="https://www.czbiohub.org/sf/wp-content/uploads/sites/18/2024/11/sf-research-mobile.webp" alt="Shots of CZ Biohub SF doing research in three bubbles"> </figure> </div> </section>  <section class="video-modals"> <aside class="card__video-modal" data-modal="true" data-video="l1v1f6mtgl"> <div class="card__video-modal__container"> <div class="video-wrapper" video-wistia data-video-id="l1v1f6mtgl"> <div class="video wistia_embed wistia_async_l1v1f6mtgl videoFoam=true autoPlay=false controlsVisibleOnLoad=true endVideoBehavior=reset fullscreenButton=true playbar=true silentAutoPlay=true playButton=false settingsControl=true smallPlayButton=true volumeControl=true muted=false fitStrategy=true "></div> </div> <div class="card__video-modal__actions"> <svg width="14" height="14" viewBox="0 0 14 14" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M12.59 0L7 5.59L1.41 0L0 1.41L5.59 7L0 12.59L1.41 14L7 8.41L12.59 14L14 12.59L8.41 7L14 1.41L12.59 0Z" fill="#DADADA"/> </svg> </div> <div class="card__video-modal__data"> <h3><strong>A Model for the Nation</strong> - COVID-19 Testing Lab</h3> <p>By leveraging the resources of UCSF, CZ Biohub and CZI, the team was uniquely positioned to build one of these expansion labs. With supply chains at a standstill, engineering teams from CZI and the CZ Biohub designed and built hardware machines from scratch. CZ Biohub data science and information teams also developed an entire data system with support from CZI software engineers and by using novel solutions. 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