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class="vector-toc-numb">2</span> <span>Types</span> </div> </a> <button aria-controls="toc-Types-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Types subsection</span> </button> <ul id="toc-Types-sublist" class="vector-toc-list"> <li id="toc-Cysteinyl_leukotrienes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cysteinyl_leukotrienes"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Cysteinyl leukotrienes</span> </div> </a> <ul id="toc-Cysteinyl_leukotrienes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-LTB4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#LTB4"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>LTB<sub>4</sub></span> </div> </a> <ul id="toc-LTB4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-LTG4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#LTG4"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>LTG<sub>4</sub></span> </div> </a> <ul id="toc-LTG4-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-LTB5" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#LTB5"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.4</span> <span>LTB<sub>5</sub></span> </div> </a> <ul id="toc-LTB5-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Biochemistry" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Biochemistry"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Biochemistry</span> </div> </a> <button aria-controls="toc-Biochemistry-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Biochemistry subsection</span> </button> <ul id="toc-Biochemistry-sublist" class="vector-toc-list"> <li id="toc-Synthesis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Synthesis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Synthesis</span> </div> </a> <ul id="toc-Synthesis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Leukotrienes_in_asthma" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Leukotrienes_in_asthma"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Leukotrienes in asthma</span> </div> </a> <button aria-controls="toc-Leukotrienes_in_asthma-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Leukotrienes in asthma subsection</span> </button> <ul id="toc-Leukotrienes_in_asthma-sublist" class="vector-toc-list"> <li id="toc-Role_of_cysteinyl_leukotrienes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_of_cysteinyl_leukotrienes"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Role of cysteinyl leukotrienes</span> </div> </a> <ul id="toc-Role_of_cysteinyl_leukotrienes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Leukotrienes_in_dementia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Leukotrienes_in_dementia"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Leukotrienes in dementia</span> </div> </a> <ul id="toc-Leukotrienes_in_dementia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" 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Available in 27 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-27" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">27 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%84%D9%88%D9%83%D9%88%D8%AA%D8%B1%D8%A7%D9%8A%D9%8A%D9%86" title="لوكوترايين – Arabic" lang="ar" hreflang="ar" data-title="لوكوترايين" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Leukotrieny" title="Leukotrieny – Czech" lang="cs" hreflang="cs" data-title="Leukotrieny" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Leukotriene" title="Leukotriene – German" lang="de" hreflang="de" data-title="Leukotriene" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Leucotrieno" title="Leucotrieno – Spanish" lang="es" hreflang="es" data-title="Leucotrieno" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Leukotrieno" title="Leukotrieno – Basque" lang="eu" hreflang="eu" data-title="Leukotrieno" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%84%DA%A9%D9%88%D8%AA%D8%B1%DB%8C%D9%86" title="لکوترین – Persian" lang="fa" hreflang="fa" data-title="لکوترین" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Leucotri%C3%A8ne" title="Leucotriène – French" lang="fr" hreflang="fr" data-title="Leucotriène" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Leucotrieno" title="Leucotrieno – Galician" lang="gl" hreflang="gl" data-title="Leucotrieno" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%A5%98%EC%BD%94%ED%8A%B8%EB%A6%AC%EC%97%94" title="류코트리엔 – Korean" lang="ko" hreflang="ko" data-title="류코트리엔" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Leukotriena" title="Leukotriena – Indonesian" lang="id" hreflang="id" data-title="Leukotriena" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Leucotrieni" title="Leucotrieni – Italian" lang="it" hreflang="it" data-title="Leucotrieni" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%9B%D0%B5%D0%B9%D0%BA%D0%BE%D1%82%D1%80%D0%B8%D0%B5%D0%BD%D0%B4%D0%B5%D1%80" title="Лейкотриендер – Kazakh" lang="kk" hreflang="kk" data-title="Лейкотриендер" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%9B%D0%B5%D0%B9%D0%BA%D0%BE%D1%82%D1%80%D0%B8%D0%B5%D0%BD" title="Лейкотриен – Mongolian" lang="mn" hreflang="mn" data-title="Лейкотриен" data-language-autonym="Монгол" data-language-local-name="Mongolian" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Leukotrieen" title="Leukotrieen – Dutch" lang="nl" hreflang="nl" data-title="Leukotrieen" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%AD%E3%82%A4%E3%82%B3%E3%83%88%E3%83%AA%E3%82%A8%E3%83%B3" title="ロイコトリエン – Japanese" lang="ja" hreflang="ja" data-title="ロイコトリエン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Leukotrieny" title="Leukotrieny – Polish" lang="pl" hreflang="pl" data-title="Leukotrieny" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Leucotrieno" title="Leucotrieno – Portuguese" lang="pt" hreflang="pt" data-title="Leucotrieno" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Leucotrien%C4%83" title="Leucotrienă – Romanian" lang="ro" hreflang="ro" data-title="Leucotrienă" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9B%D0%B5%D0%B9%D0%BA%D0%BE%D1%82%D1%80%D0%B8%D0%B5%D0%BD%D1%8B" title="Лейкотриены – Russian" lang="ru" hreflang="ru" data-title="Лейкотриены" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Leukotrien" title="Leukotrien – Serbian" lang="sr" hreflang="sr" data-title="Leukotrien" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Leukotrien" title="Leukotrien – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Leukotrien" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Leukotrieenit" title="Leukotrieenit – Finnish" lang="fi" hreflang="fi" data-title="Leukotrieenit" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Leukotrien" title="Leukotrien – Swedish" lang="sv" hreflang="sv" data-title="Leukotrien" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%B2%E0%AF%81%E0%AE%AF%E0%AF%82%E0%AE%95%E0%AF%8D%E0%AE%95%E0%AF%8B%E0%AE%9F%E0%AE%BF%E0%AE%B0%E0%AF%88%E0%AE%AF%E0%AF%80%E0%AE%A9%E0%AF%8D" title="லுயூக்கோடிரையீன் – Tamil" lang="ta" hreflang="ta" data-title="லுயூக்கோடிரையீன்" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9B%D0%B5%D0%B9%D0%BA%D0%BE%D1%82%D1%80%D1%96%D1%94%D0%BD%D0%B8" 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dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Class of inflammation mediator molecules</div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Leukotriene_A4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Leukotriene_A4.svg/220px-Leukotriene_A4.svg.png" decoding="async" width="220" height="72" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/Leukotriene_A4.svg/330px-Leukotriene_A4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/55/Leukotriene_A4.svg/440px-Leukotriene_A4.svg.png 2x" data-file-width="420" data-file-height="137" /></a><figcaption><a href="/wiki/Leukotriene_A4" title="Leukotriene A4">LTA<sub>4</sub></a> Note the four double bonds, three of them conjugated. This is a common property of A4, B4, C4, D4, and E4.</figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Leukotriene_B4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Leukotriene_B4.svg/220px-Leukotriene_B4.svg.png" decoding="async" width="220" height="67" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/77/Leukotriene_B4.svg/330px-Leukotriene_B4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/77/Leukotriene_B4.svg/440px-Leukotriene_B4.svg.png 2x" data-file-width="420" data-file-height="128" /></a><figcaption><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB<sub>4</sub></a></figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Leukotriene_C4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Leukotriene_C4.svg/220px-Leukotriene_C4.svg.png" decoding="async" width="220" height="199" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Leukotriene_C4.svg/330px-Leukotriene_C4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Leukotriene_C4.svg/440px-Leukotriene_C4.svg.png 2x" data-file-width="420" data-file-height="380" /></a><figcaption><a href="/wiki/Leukotriene_C4" title="Leukotriene C4">LTC<sub>4</sub></a> is a cysteinyl leukotriene, as are D4 and E4.</figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Leukotriene_D4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/Leukotriene_D4.svg/220px-Leukotriene_D4.svg.png" decoding="async" width="220" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/Leukotriene_D4.svg/330px-Leukotriene_D4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d2/Leukotriene_D4.svg/440px-Leukotriene_D4.svg.png 2x" data-file-width="420" data-file-height="245" /></a><figcaption><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">LTD<sub>4</sub></a></figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Leukotriene_E4.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Leukotriene_E4.svg/220px-Leukotriene_E4.svg.png" decoding="async" width="220" height="128" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Leukotriene_E4.svg/330px-Leukotriene_E4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Leukotriene_E4.svg/440px-Leukotriene_E4.svg.png 2x" data-file-width="420" data-file-height="245" /></a><figcaption><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">LTE<sub>4</sub></a></figcaption></figure> <p><b>Leukotrienes</b> are a family of <a href="/wiki/Eicosanoid" title="Eicosanoid">eicosanoid</a> <a href="/wiki/Inflammation" title="Inflammation">inflammatory mediators</a> produced in <a href="/wiki/Leukocyte" class="mw-redirect" title="Leukocyte">leukocytes</a> by the <a href="/wiki/Redox" title="Redox">oxidation</a> of <a href="/wiki/Arachidonic_acid" title="Arachidonic acid">arachidonic acid</a> (AA) and the <a href="/wiki/Essential_fatty_acid" title="Essential fatty acid">essential fatty acid</a> <a href="/wiki/Eicosapentaenoic_acid" title="Eicosapentaenoic acid">eicosapentaenoic acid</a> (EPA) by the <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> <a href="/wiki/Arachidonate_5-lipoxygenase" title="Arachidonate 5-lipoxygenase">arachidonate 5-lipoxygenase</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Leukotrienes use <a href="/wiki/Lipid_signaling" title="Lipid signaling">lipid signaling</a> to convey information to either the cell producing them (<a href="/wiki/Autocrine_signaling" title="Autocrine signaling">autocrine signaling</a>) or neighboring cells (<a href="/wiki/Paracrine_signaling" title="Paracrine signaling">paracrine signaling</a>) in order to regulate immune responses. The production of leukotrienes is usually accompanied by the production of <a href="/wiki/Histamine" title="Histamine">histamine</a> and <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandins</a>, which also act as inflammatory mediators.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>One of their roles (specifically, <a href="/wiki/Leukotriene_D4" title="Leukotriene D4">leukotriene D<sub>4</sub></a>) is to trigger contractions in the smooth muscles lining the bronchioles; their overproduction is a major cause of inflammation in <a href="/wiki/Asthma" title="Asthma">asthma</a> and allergic <a href="/wiki/Rhinitis" title="Rhinitis">rhinitis</a>.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Leukotriene_antagonist" class="mw-redirect" title="Leukotriene antagonist">Leukotriene antagonists</a> are used to treat these disorders by inhibiting the production or activity of leukotrienes.<sup id="cite_ref-Antileukotriene_6-0" class="reference"><a href="#cite_note-Antileukotriene-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History_and_name">History and name</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=1" title="Edit section: History and name"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The name <i>leukotriene</i>, introduced by Swedish biochemist <a href="/wiki/Bengt_Samuelsson" class="mw-redirect" title="Bengt Samuelsson">Bengt Samuelsson</a> in 1979, comes from the words <i>leukocyte</i> and <i><a href="/wiki/Triene" class="mw-redirect" title="Triene">triene</a></i> (indicating the compound's three <a href="/wiki/Conjugated_system" title="Conjugated system">conjugated double bonds</a>). What would be later named leukotriene C, "slow reaction smooth muscle-stimulating substance" (<a href="/wiki/Slow-reacting_substance_of_anaphylaxis" title="Slow-reacting substance of anaphylaxis">SRS</a>) was originally described between 1938 and 1940 by Feldberg and Kellaway.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kellaway_9-0" class="reference"><a href="#cite_note-Kellaway-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The researchers isolated SRS from lung tissue after a prolonged period following exposure to snake <a href="/wiki/Venom" title="Venom">venom</a> and histamine.<sup id="cite_ref-Kellaway_9-1" class="reference"><a href="#cite_note-Kellaway-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Types">Types</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=2" title="Edit section: Types"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Cysteinyl_leukotrienes">Cysteinyl leukotrienes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=3" title="Edit section: Cysteinyl leukotrienes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Leukotriene_C4" title="Leukotriene C4">LTC<sub>4</sub></a>, <a href="/wiki/Leukotriene_D4" title="Leukotriene D4">LTD<sub>4</sub></a>, <a href="/wiki/Leukotriene_E4" title="Leukotriene E4">LTE<sub>4</sub></a> and LTF<sub>4</sub> are often called <b>cysteinyl leukotrienes</b> due to the presence of the amino acid <a href="/wiki/Cysteine" title="Cysteine">cysteine</a> in their structure. The cysteinyl leukotrienes make up the <a href="/wiki/Slow-reacting_substance_of_anaphylaxis" title="Slow-reacting substance of anaphylaxis">slow-reacting substance of anaphylaxis</a> (SRS-A). LTF<sub>4</sub>, like LTD<sub>4</sub>, is a metabolite of LTC<sub>4</sub>, but, unlike LTD<sub>4</sub>, which lacks the <a href="/wiki/Glutamate" class="mw-redirect" title="Glutamate">glutamic</a> residue of <a href="/wiki/Glutathione" title="Glutathione">glutathione</a>, LTF<sub>4</sub> lacks the <a href="/wiki/Glycine" title="Glycine">glycine</a> residue of glutathione.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="LTB4">LTB<sub>4</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=4" title="Edit section: LTB4"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Leukotriene_B4" title="Leukotriene B4">Leukotriene B4</a></div> <p><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB<sub>4</sub></a> is synthesized <i>in vivo</i> from <a href="/wiki/Leukotriene_A4" title="Leukotriene A4">LTA<sub>4</sub></a> by the enzyme <a href="/wiki/Leukotriene-A4_hydrolase" title="Leukotriene-A4 hydrolase">LTA<sub>4</sub> hydrolase</a>. Its primary function is to recruit neutrophils to areas of tissue damage, though it also helps promote the production of inflammatory cytokines by various immune cells. Drugs that block the actions of LTB<sub>4</sub> have shown some efficacy in slowing the progression of neutrophil-mediated diseases.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="LTG4">LTG<sub>4</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=5" title="Edit section: LTG4"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There has also been postulated the existence of LTG<sub>4</sub>, a metabolite of LTE<sub>4</sub> in which the cysteinyl <a href="/wiki/Functional_group" title="Functional group">moiety</a> has been oxidized to an alpha-keto-acid (i.e.—the cysteine has been replaced by a <a href="/wiki/Pyruvate" class="mw-redirect" title="Pyruvate">pyruvate</a>). Very little is known about this putative leukotriene.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="LTB5">LTB<sub>5</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=6" title="Edit section: LTB5"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Leukotrienes originating from the omega-3 class eicosapentanoic acid (EPA) have diminished inflammatory effects. In human subjects whose diets have been supplemented with eicosapentaenoic acid, leukotrine B5, along with leukotrine B4, is produced by neutrophils.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> LTB<sub>5</sub> induces aggregation of rat <a href="/wiki/Neutrophils" class="mw-redirect" title="Neutrophils">neutrophils</a>, chemokinesis of human polymorphonuclear neutrophils (PMN), lysosomal enzyme release from human PMN and potentiation of bradykinin-induced plasma exudation, although compared to LTB<sub>4</sub>, it has at least 30 times less potency.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biochemistry">Biochemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=7" title="Edit section: Biochemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Synthesis">Synthesis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=8" title="Edit section: Synthesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Eicosanoid_synthesis.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/40/Eicosanoid_synthesis.svg/320px-Eicosanoid_synthesis.svg.png" decoding="async" width="320" height="252" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/40/Eicosanoid_synthesis.svg/480px-Eicosanoid_synthesis.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/40/Eicosanoid_synthesis.svg/640px-Eicosanoid_synthesis.svg.png 2x" data-file-width="512" data-file-height="403" /></a><figcaption>Eicosanoid synthesis. (Leukotrienes at right.)</figcaption></figure> <p>Leukotrienes are synthesized in the cell from <a href="/wiki/Arachidonic_acid" title="Arachidonic acid">arachidonic acid</a> by <a href="/wiki/Arachidonate_5-lipoxygenase" title="Arachidonate 5-lipoxygenase">arachidonate 5-lipoxygenase</a>. The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the arachidonic acid backbone.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p><p>The lipoxygenase pathway is active in leukocytes and other immunocompetent cells, including <a href="/wiki/Mast_cell" title="Mast cell">mast cells</a>, <a href="/wiki/Eosinophil" title="Eosinophil">eosinophils</a>, <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a>, <a href="/wiki/Monocyte" title="Monocyte">monocytes</a>, and <a href="/wiki/Basophil" title="Basophil">basophils</a>. When such cells are activated, arachidonic acid is liberated from cell membrane phospholipids by <a href="/wiki/Phospholipase_A2" title="Phospholipase A2">phospholipase A2</a>, and donated by the <a href="/wiki/5-lipoxygenase-activating_protein" title="5-lipoxygenase-activating protein">5-lipoxygenase-activating protein</a> (FLAP) to 5-lipoxygenase.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p><p>5-<a href="/wiki/Lipoxygenase" title="Lipoxygenase">Lipoxygenase</a> (5-LO) uses FLAP to convert arachidonic acid into 5-hydroperoxyeicosatetraenoic acid (5-HPETE), which spontaneously <a href="/wiki/Redox" title="Redox">reduces</a> to <a href="/wiki/5-hydroxyeicosatetraenoic_acid" class="mw-redirect" title="5-hydroxyeicosatetraenoic acid">5-hydroxyeicosatetraenoic acid</a> (5-HETE). The enzyme 5-LO acts again on 5-HETE to convert it into <a href="/wiki/Leukotriene_A4" title="Leukotriene A4">leukotriene A<sub>4</sub></a> (LTA<sub>4</sub>), an unstable epoxide. 5-HETE can be further metabolized to 5-oxo-ETE and 5-oxo-15-hydroxy-ETE, all of which have pro-inflammatory actions similar but not identical to those of LTB<sub>4</sub> and mediated not by LTB<sub>4</sub> receptors but rather by the OXE receptor (see <a href="/wiki/5-Hydroxyeicosatetraenoic_acid" title="5-Hydroxyeicosatetraenoic acid">5-Hydroxyeicosatetraenoic acid</a> and <a href="/wiki/5-Oxo-eicosatetraenoic_acid" title="5-Oxo-eicosatetraenoic acid">5-Oxo-eicosatetraenoic acid</a>).<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>In cells equipped with <a href="/wiki/Leukotriene_A4_hydrolase" class="mw-redirect" title="Leukotriene A4 hydrolase">LTA hydrolase</a>, such as neutrophils and monocytes, LTA<sub>4</sub> is converted to the dihydroxy acid leukotriene LTB<sub>4</sub>, which is a powerful chemoattractant for neutrophils acting at BLT<sub>1</sub> and BLT<sub>2</sub> receptors on the plasma membrane of these cells.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p><p>In cells that express <a href="/wiki/Leukotriene_C4_synthase" title="Leukotriene C4 synthase">LTC<sub>4</sub> synthase</a>, such as mast cells and eosinophils, LTA<sub>4</sub> is conjugated with the tripeptide <a href="/wiki/Glutathione" title="Glutathione">glutathione</a> to form the first of the cysteinyl-leukotrienes, LTC<sub>4</sub>. Outside the cell, LTC<sub>4</sub> can be converted by ubiquitous enzymes to form successively LTD<sub>4</sub> and LTE<sub>4</sub>, which retain <a href="/wiki/Biological_activity" title="Biological activity">biological activity</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p><p>The cysteinyl-leukotrienes act at their cell-surface receptors <a href="/wiki/CysLT1" class="mw-redirect" title="CysLT1">CysLT1</a> and <a href="/wiki/CysLT2" class="mw-redirect" title="CysLT2">CysLT2</a> on target cells to contract bronchial and vascular smooth muscle, to increase permeability of small blood vessels, to enhance secretion of mucus in the airway and gut, and to recruit leukocytes to sites of inflammation.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p><p>Both LTB<sub>4</sub> and the cysteinyl-leukotrienes (LTC<sub>4</sub>, LTD<sub>4</sub>, LTE<sub>4</sub>) are partly degraded in local tissues, and ultimately become inactive metabolites in the liver.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (April 2016)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Function">Function</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=9" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Leukotrienes act principally on a subfamily of <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptors</a>. They may also act upon <a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">peroxisome proliferator-activated receptors</a>. Leukotrienes are involved in asthmatic and allergic reactions and act to sustain inflammatory reactions. Several <a href="/wiki/Leukotriene_receptor_antagonist" class="mw-redirect" title="Leukotriene receptor antagonist">leukotriene receptor antagonists</a> such as <a href="/wiki/Montelukast" title="Montelukast">montelukast</a> and <a href="/wiki/Zafirlukast" title="Zafirlukast">zafirlukast</a> are used to treat <a href="/wiki/Asthma" title="Asthma">asthma</a>. Recent research points to a role of 5-lipoxygenase in cardiovascular and neuropsychiatric illnesses.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>Leukotrienes are very important agents in the <a href="/wiki/Inflammation" title="Inflammation">inflammatory</a> response. Some such as LTB<sub>4</sub> have a <a href="/wiki/Chemotactic" class="mw-redirect" title="Chemotactic">chemotactic</a> effect on migrating neutrophils, and as such help to bring the necessary cells to the tissue. Leukotrienes also have a powerful effect in <a href="/wiki/Bronchoconstriction" title="Bronchoconstriction">bronchoconstriction</a> and increase <a href="/wiki/Vascular_permeability" title="Vascular permeability">vascular permeability</a>.<sup id="cite_ref-lppl_17-0" class="reference"><a href="#cite_note-lppl-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Leukotrienes_in_asthma">Leukotrienes in asthma</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=10" title="Edit section: Leukotrienes in asthma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Leukotrienes contribute to the <a href="/wiki/Pathophysiology" title="Pathophysiology">pathophysiology</a> of <a href="/wiki/Asthma" title="Asthma">asthma</a>, especially in patients with <a href="/wiki/Aspirin-exacerbated_respiratory_disease" title="Aspirin-exacerbated respiratory disease">aspirin-exacerbated respiratory disease</a> (AERD), and cause or <a href="/wiki/Potentiator" title="Potentiator">potentiate</a> the following <a href="/wiki/Symptom" class="mw-redirect" title="Symptom">symptoms</a>:<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Airflow obstruction</li> <li>Increased secretion of mucus</li> <li>Mucosal accumulation</li> <li>Bronchoconstriction</li> <li>Infiltration of inflammatory cells in the airway wall</li></ul> <div class="mw-heading mw-heading3"><h3 id="Role_of_cysteinyl_leukotrienes">Role of cysteinyl leukotrienes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=11" title="Edit section: Role of cysteinyl leukotrienes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cysteinyl leukotriene receptors <a href="/wiki/CYSLTR1" class="mw-redirect" title="CYSLTR1">CYSLTR1</a> and <a href="/wiki/CYSLTR2" class="mw-redirect" title="CYSLTR2">CYSLTR2</a> are present on mast cells, eosinophil, and endothelial cells. During cysteinyl leukotriene interaction, they can stimulate proinflammatory activities such as endothelial cell adherence and chemokine production by mast cells. As well as mediating inflammation, they induce asthma and other inflammatory disorders, thereby reducing the airflow to the <a href="/wiki/Pulmonary_alveolus" title="Pulmonary alveolus">alveoli</a>. The levels of cysteinyl leukotrienes, along with <a href="/wiki/Isoprostane" title="Isoprostane">8-isoprostane</a>, have been reported to be increased in the <a href="/wiki/Exhaled_breath_condensate" title="Exhaled breath condensate">EBC</a> of patients with <a href="/wiki/Asthma" title="Asthma">asthma</a>, correlating with disease severity.<sup id="cite_ref-Samitas_19-0" class="reference"><a href="#cite_note-Samitas-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Cysteinyl leukotrienes may also play a role in adverse drug reactions in general and in contrast medium induced adverse reactions in particular.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p><p>In excess, the cysteinyl leukotrienes can induce <a href="/wiki/Anaphylaxis" title="Anaphylaxis">anaphylactic shock</a>.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Leukotrienes_in_dementia">Leukotrienes in dementia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=12" title="Edit section: Leukotrienes in dementia"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Leukotrienes are found to play an important role in the later stages of <a href="/wiki/Alzheimer%27s" class="mw-redirect" title="Alzheimer's">Alzheimer's</a> disease and related <a href="/wiki/Dementias" class="mw-redirect" title="Dementias">dementias</a> in studies with animals. In tau <a href="/wiki/Transgenic" class="mw-redirect" title="Transgenic">transgenic</a> mice, which develop <a href="/wiki/Tau_pathology" class="mw-redirect" title="Tau pathology">tau pathology</a>, "<a href="/wiki/Zileuton" title="Zileuton">zileuton</a>, a drug that inhibits leukotriene formation by blocking the <a href="/wiki/Arachidonate_5-lipoxygenase" title="Arachidonate 5-lipoxygenase">5-lipoxygenase enzyme</a>" was found to reverse <a href="/wiki/Memory_loss" class="mw-redirect" title="Memory loss">memory loss</a>.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=13" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Wittig_reaction#Examples_of_use" title="Wittig reaction">A chemical synthesis of Leukotriene A methyl ester</a></li> <li><a href="/wiki/Eoxin" title="Eoxin">Eoxins</a> (14,15-leukotrienes)</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=14" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFLoickTheissen1994" class="citation journal cs1 cs1-prop-foreign-lang-source">Loick, H.; Theissen, J. (1994). "Die Eicosanoide als Mediatoren beim ARDS" [Eicosanoids as mediators in ARDS]. <i>Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie</i> (in German). <b>29</b> (1): 3–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1055%2Fs-2007-996677">10.1055/s-2007-996677</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8142566">8142566</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=An%C3%A4sthesiologie%2C+Intensivmedizin%2C+Notfallmedizin%2C+Schmerztherapie&rft.atitle=Die+Eicosanoide+als+Mediatoren+beim+ARDS&rft.volume=29&rft.issue=1&rft.pages=3-9&rft.date=1994&rft_id=info%3Adoi%2F10.1055%2Fs-2007-996677&rft_id=info%3Apmid%2F8142566&rft.aulast=Loick&rft.aufirst=H.&rft.au=Theissen%2C+J.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALeukotriene" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSalmonHiggs1987" class="citation journal cs1">Salmon, John A; Higgs, Gerald A (1987). "Prostaglandins and leukotrienes as inflammatory mediators". <i>British Medical Bulletin</i>. <b>43</b> (2): 285–96. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Foxfordjournals.bmb.a072183">10.1093/oxfordjournals.bmb.a072183</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2825898">2825898</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Medical+Bulletin&rft.atitle=Prostaglandins+and+leukotrienes+as+inflammatory+mediators&rft.volume=43&rft.issue=2&rft.pages=285-96&rft.date=1987&rft_id=info%3Adoi%2F10.1093%2Foxfordjournals.bmb.a072183&rft_id=info%3Apmid%2F2825898&rft.aulast=Salmon&rft.aufirst=John+A&rft.au=Higgs%2C+Gerald+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALeukotriene" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'ByrneIsraelDrazen1997" class="citation journal cs1">O'Byrne, Paul M.; Israel, Elliot; Drazen, Jeffrey M. 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June 8, 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Eurekalart%21&rft.atitle=Temple+researchers+reverse+cognitive+impairments+in+mice+with+dementia&rft.date=2018-06-08&rft_id=https%3A%2F%2Fwww.eurekalert.org%2Fpub_releases%2F2018-06%2Ftuhs-trr060818.php&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALeukotriene" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=15" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Bailey, J. Martyn (1985) <i>Prostaglandins, leukotrienes, and lipoxins: biochemistry, mechanism of action, and clinical applications</i> Plenum Press, New York, <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0-306-41980-7" title="Special:BookSources/0-306-41980-7">0-306-41980-7</a></li> <li>Lipkowitz, Myron A. and Navarra, Tova (2001) <i>The Encyclopedia of Allergies</i> (2nd ed.) Facts on File, New York, p. 167, <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0-8160-4404-X" title="Special:BookSources/0-8160-4404-X">0-8160-4404-X</a></li> <li>Samuelsson, Bengt (ed.) (2001) <i>Advances in prostaglandin and leukotriene research: basic science and new clinical applications: 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, Florence, Italy, June 4–8, 2000</i> Kluwer Academic Publishers, Dordrecht, <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/1-4020-0146-0" title="Special:BookSources/1-4020-0146-0">1-4020-0146-0</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Leukotriene&action=edit&section=16" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Leukotrienes">Leukotrienes</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist 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.navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Eicosanoids" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse 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href="/wiki/Eicosanoid" title="Eicosanoid">Eicosanoids</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Precursor</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prostanoid" title="Prostanoid">Prostanoids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prostaglandin" title="Prostaglandin">Prostaglandins</a> (PG)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Precursor</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prostaglandin_H2" title="Prostaglandin H2">H<sub>2</sub></a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Active</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">D/J</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">D<sub>2</sub></a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prostaglandin_E" title="Prostaglandin E">E</a>/F</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">E<sub>2</sub> (Dinoprostone)</a></li></ul> <ul><li><a href="/wiki/Prostaglandin_E1" title="Prostaglandin E1">E<sub>1</sub> (Alprostadil)</a></li></ul> <ul><li><a href="/wiki/Prostaglandin_F2alpha" title="Prostaglandin F2alpha">F<sub>2α</sub> (Dinoprost)</a>:</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">I</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prostacyclin" title="Prostacyclin">I<sub>2</sub> (Prostacyclin/Epoprostenol)</a>:</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thromboxane" title="Thromboxane">Thromboxanes</a> (TX)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">A<sub>2</sub></a></li> <li><a href="/wiki/Thromboxane_B2" title="Thromboxane B2">B<sub>2</sub></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a class="mw-selflink selflink">Leukotrienes</a> (LT)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Precursor</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Arachidonic_acid_5-hydroperoxide" title="Arachidonic acid 5-hydroperoxide">Arachidonic acid 5-hydroperoxide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Initial</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukotriene_A4" title="Leukotriene A4">A<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">B<sub>4</sub></a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Slow-reacting_substance_of_anaphylaxis" title="Slow-reacting substance of anaphylaxis">SRS-A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukotriene_C4" title="Leukotriene C4">C<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">D<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">E<sub>4</sub></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eoxin" title="Eoxin">Eoxins</a> (EX)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Precursor</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Arachidonic_acid_15-hydroperoxide&action=edit&redlink=1" class="new" title="Arachidonic acid 15-hydroperoxide (page does not exist)">Arachidonic acid 15-hydroperoxide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Eoxins</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Eoxin_A4" title="Eoxin A4">A<sub>4</sub></a></li> <li><a href="/wiki/Eoxin_C4" title="Eoxin C4">C<sub>4</sub></a></li> <li><a href="/wiki/Eoxin_D4" title="Eoxin D4">D<sub>4</sub></a></li> <li><a href="/wiki/Eoxin_E4" title="Eoxin E4">E<sub>4</sub></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nonclassic_eicosanoid" title="Nonclassic eicosanoid">Nonclassic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lipoxin" title="Lipoxin">Lipoxins</a> (LX) (<a href="/wiki/Lipoxin" title="Lipoxin">A<sub>4</sub></a>, <a href="/wiki/Lipoxin" title="Lipoxin">B<sub>4</sub></a>)</li> <li><a href="/wiki/Virodhamine" title="Virodhamine">Virodhamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By function</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Bronchoconstriction" title="Bronchoconstriction">bronchoconstriction</a></i> <ul><li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">PGD<sub>2</sub></a></li> <li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">TXA<sub>2</sub></a></li> <li><a href="/wiki/Leukotriene_C4" title="Leukotriene C4">LTC<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">LTD<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">LTE<sub>4</sub></a></li></ul></li></ul> <ul><li><i><a href="/wiki/Vasoconstriction" title="Vasoconstriction">vasoconstriction</a></i> <ul><li><a href="/wiki/Prostaglandin_F2alpha" title="Prostaglandin F2alpha">PGF<sub>2α</sub></a></li> <li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">TXA<sub>2</sub></a></li> <li><a href="/wiki/Thromboxane_B2" title="Thromboxane B2">TXB<sub>2</sub></a></li></ul></li> <li><i><a href="/wiki/Vasodilation" title="Vasodilation">vasodilation</a></i> <ul><li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">PGE<sub>2</sub></a></li> <li><a href="/wiki/Prostacyclin" title="Prostacyclin">PGI<sub>2</sub></a></li> <li><a href="/wiki/Leukotriene_C4" title="Leukotriene C4">LTC<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">LTD<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">LTE<sub>4</sub></a></li></ul></li></ul> <ul><li><i><a href="/wiki/Platelet" title="Platelet">platelets</a>: induce</i> <ul><li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">TXA<sub>2</sub></a></li></ul></li> <li><i>inhibit</i> <ul><li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">PGD<sub>2</sub></a></li> <li><a href="/wiki/Prostacyclin" title="Prostacyclin">PGI<sub>2</sub></a></li></ul></li> <li><i><a href="/wiki/Leukocyte" class="mw-redirect" title="Leukocyte">leukocytes</a>: induce</i> <ul><li><a href="/wiki/Thromboxane_A2" title="Thromboxane A2">TXA<sub>2</sub></a></li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB<sub>4</sub></a></li></ul></li> <li><i>inhibit</i> <ul><li><a href="/wiki/Prostaglandin_D2" title="Prostaglandin D2">PGD<sub>2</sub></a></li> <li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">PGE<sub>2</sub></a></li></ul></li></ul> <ul><li><i><a href="/wiki/Fever" title="Fever">fever</a> stimulation:</i> <ul><li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">PGE<sub>2</sub></a></li></ul></li></ul> <ul><li><i><a href="/wiki/Childbirth" title="Childbirth">labor</a> stimulation:</i> <ul><li><a href="/wiki/Prostaglandin_E2" title="Prostaglandin E2">PGE<sub>2</sub></a> (Dinoprostone)</li> <li><a href="/wiki/Prostaglandin_F2alpha" title="Prostaglandin F2alpha">PGF<sub>2α</sub></a> (Dinoprost)</li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Leukotriene_signaling_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Leukotriene_signaling_modulators" title="Template:Leukotriene signaling modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Leukotriene_signaling_modulators" title="Template talk:Leukotriene signaling modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Leukotriene_signaling_modulators" title="Special:EditPage/Template:Leukotriene signaling modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Leukotriene_signaling_modulators" style="font-size:114%;margin:0 4em"><a class="mw-selflink selflink">Leukotriene</a> <a href="/wiki/Cell_signaling" title="Cell signaling">signaling</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a><br /><small>(<a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_B4_receptor" title="Leukotriene B4 receptor"><abbr title="Leukotriene B4 receptor">BLT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene B4 receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_B4_receptor_1" title="Leukotriene B4 receptor 1"><abbr title="Leukotriene B4 receptor 1">BLT<sub>1</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene B4 receptor 1</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/12-Hydroxyeicosatetraenoic_acid" title="12-Hydroxyeicosatetraenoic acid">12-HETE</a></li> <li><a href="/w/index.php?title=20-Hydroxy-LTB4&action=edit&redlink=1" class="new" title="20-Hydroxy-LTB4 (page does not exist)">20-Hydroxy-LTB<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">Leukotriene B<sub>4</sub></a></li> <li><a href="/w/index.php?title=LY-255283&action=edit&redlink=1" class="new" title="LY-255283 (page does not exist)">LY-255283</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=20-Carboxy-LTB4&action=edit&redlink=1" class="new" title="20-Carboxy-LTB4 (page does not exist)">20-Carboxy-LTB<sub>4</sub></a></li> <li><a href="/w/index.php?title=Amelubant&action=edit&redlink=1" class="new" title="Amelubant (page does not exist)">Amelubant</a></li> <li><a href="/w/index.php?title=CGS-23131&action=edit&redlink=1" class="new" title="CGS-23131 (page does not exist)">CGS-23131 (LY-223982)</a></li> <li><a href="/w/index.php?title=CGS-25019C&action=edit&redlink=1" class="new" title="CGS-25019C (page does not exist)">CGS-25019C</a></li> <li><a href="/w/index.php?title=CP-105696&action=edit&redlink=1" class="new" title="CP-105696 (page does not exist)">CP-105696</a></li> <li><a href="/w/index.php?title=CP-195543&action=edit&redlink=1" class="new" title="CP-195543 (page does not exist)">CP-195543</a></li> <li><a href="/wiki/Etalocib" title="Etalocib">Etalocib</a></li> <li><a href="/w/index.php?title=LY-293111&action=edit&redlink=1" class="new" title="LY-293111 (page does not exist)">LY-293111</a></li> <li><a href="/w/index.php?title=Moxilubant&action=edit&redlink=1" class="new" title="Moxilubant (page does not exist)">Moxilubant</a></li> <li><a href="/w/index.php?title=ONO-4057&action=edit&redlink=1" class="new" title="ONO-4057 (page does not exist)">ONO-4057</a></li> <li><a href="/w/index.php?title=RG-14893&action=edit&redlink=1" class="new" title="RG-14893 (page does not exist)">RG-14893</a></li> <li><a href="/w/index.php?title=RP-69698&action=edit&redlink=1" class="new" title="RP-69698 (page does not exist)">RP-69698</a></li> <li><a href="/w/index.php?title=SB-209247&action=edit&redlink=1" class="new" title="SB-209247 (page does not exist)">SB-209247</a></li> <li><a href="/w/index.php?title=SC-53228&action=edit&redlink=1" class="new" title="SC-53228 (page does not exist)">SC-53228</a></li> <li><a href="/w/index.php?title=Ticolubant&action=edit&redlink=1" class="new" title="Ticolubant (page does not exist)">Ticolubant</a></li> <li><a href="/w/index.php?title=U-75302&action=edit&redlink=1" class="new" title="U-75302 (page does not exist)">U-75302</a></li> <li><a href="/w/index.php?title=ZK-158252&action=edit&redlink=1" class="new" title="ZK-158252 (page does not exist)">ZK-158252</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_B4_receptor_2" title="Leukotriene B4 receptor 2"><abbr title="Leukotriene B4 receptor 2">BLT<sub>2</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene B4 receptor 2</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/12-Hydroxyeicosatetraenoic_acid" title="12-Hydroxyeicosatetraenoic acid">12-HETE</a></li> <li><a href="/wiki/12-Hydroxyheptadecatrienoic_acid" title="12-Hydroxyheptadecatrienoic acid">12-HHT</a></li> <li><a href="/w/index.php?title=12-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic_acid&action=edit&redlink=1" class="new" title="12-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (page does not exist)">12-HpETE</a></li> <li><a href="/wiki/15-Hydroxyeicosatetraenoic_acid" title="15-Hydroxyeicosatetraenoic acid">15-HETE</a></li> <li><a href="/w/index.php?title=15-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic_acid&action=edit&redlink=1" class="new" title="15-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (page does not exist)">15-HpETE</a></li> <li><a href="/w/index.php?title=20-Hydroxy-LTB4&action=edit&redlink=1" class="new" title="20-Hydroxy-LTB4 (page does not exist)">20-Hydroxy-LTB<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">Leukotriene B<sub>4</sub></a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=CP-195543&action=edit&redlink=1" class="new" title="CP-195543 (page does not exist)">CP-195543</a></li> <li><a href="/w/index.php?title=LY-255283&action=edit&redlink=1" class="new" title="LY-255283 (page does not exist)">LY-255283</a></li> <li><a href="/w/index.php?title=ZK-158252&action=edit&redlink=1" class="new" title="ZK-158252 (page does not exist)">ZK-158252</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cysteinyl_leukotriene_receptor" title="Cysteinyl leukotriene receptor"><abbr title="Cysteinyl leukotriene receptor">CysLT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cysteinyl leukotriene receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cysteinyl_leukotriene_receptor_1" title="Cysteinyl leukotriene receptor 1"><abbr title="Cysteinyl leukotriene receptor 1">CysLT<sub>1</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cysteinyl leukotriene receptor 1</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Leukotriene_C4" title="Leukotriene C4">Leukotriene C<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">Leukotriene D<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">Leukotriene E<sub>4</sub></a></li></ul> <ul><li><b>Antagonists:</b> <a href="/wiki/Ablukast" title="Ablukast">Ablukast</a></li> <li><a href="/w/index.php?title=BAYu9773&action=edit&redlink=1" class="new" title="BAYu9773 (page does not exist)">BAYu9773</a></li> <li><a href="/w/index.php?title=BAYu9916&action=edit&redlink=1" class="new" title="BAYu9916 (page does not exist)">BAYu9916</a></li> <li><a href="/w/index.php?title=BAYx7195&action=edit&redlink=1" class="new" title="BAYx7195 (page does not exist)">BAYx7195</a></li> <li><a href="/w/index.php?title=Cinalukast&action=edit&redlink=1" class="new" title="Cinalukast (page does not exist)">Cinalukast</a></li> <li><a href="/w/index.php?title=FPL-55712&action=edit&redlink=1" class="new" title="FPL-55712 (page does not exist)">FPL-55712</a></li> <li><a href="/w/index.php?title=ICI-198615&action=edit&redlink=1" class="new" title="ICI-198615 (page does not exist)">ICI-198615</a></li> <li><a href="/w/index.php?title=Iralukast&action=edit&redlink=1" class="new" title="Iralukast (page does not exist)">Iralukast</a></li> <li><a href="/w/index.php?title=LY-170680&action=edit&redlink=1" class="new" title="LY-170680 (page does not exist)">LY-170680</a></li> <li><a href="/w/index.php?title=Masilukast&action=edit&redlink=1" class="new" title="Masilukast (page does not exist)">Masilukast</a></li> <li><a href="/w/index.php?title=MK-571&action=edit&redlink=1" class="new" title="MK-571 (page does not exist)">MK-571</a></li> <li><a href="/wiki/Montelukast" title="Montelukast">Montelukast</a></li> <li><a href="/w/index.php?title=ONO-1078&action=edit&redlink=1" class="new" title="ONO-1078 (page does not exist)">ONO-1078</a></li> <li><a href="/w/index.php?title=Pobilukast&action=edit&redlink=1" class="new" title="Pobilukast (page does not exist)">Pobilukast</a></li> <li><a href="/wiki/Pranlukast" title="Pranlukast">Pranlukast</a></li> <li><a href="/w/index.php?title=Ritolukast&action=edit&redlink=1" class="new" title="Ritolukast (page does not exist)">Ritolukast</a></li> <li><a href="/w/index.php?title=SKF-104353&action=edit&redlink=1" class="new" title="SKF-104353 (page does not exist)">SKF-104353</a></li> <li><a href="/w/index.php?title=SR-2640&action=edit&redlink=1" class="new" title="SR-2640 (page does not exist)">SR-2640</a></li> <li><a href="/w/index.php?title=Sulukast&action=edit&redlink=1" class="new" title="Sulukast (page does not exist)">Sulukast</a></li> <li><a href="/wiki/Tipelukast" title="Tipelukast">Tipelukast</a></li> <li><a href="/w/index.php?title=Tomelukast&action=edit&redlink=1" class="new" title="Tomelukast (page does not exist)">Tomelukast</a></li> <li><a href="/w/index.php?title=Verlukast&action=edit&redlink=1" class="new" title="Verlukast (page does not exist)">Verlukast</a></li> <li><a href="/wiki/Zafirlukast" title="Zafirlukast">Zafirlukast</a></li> <li><a href="/w/index.php?title=ZD-3523&action=edit&redlink=1" class="new" title="ZD-3523 (page does not exist)">ZD-3523</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cysteinyl_leukotriene_receptor_2" title="Cysteinyl leukotriene receptor 2"><abbr title="Cysteinyl leukotriene receptor 2">CysLT<sub>2</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cysteinyl leukotriene receptor 2</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Leukotriene_C4" title="Leukotriene C4">Leukotriene C<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_D4" title="Leukotriene D4">Leukotriene D<sub>4</sub></a></li> <li><a href="/wiki/Leukotriene_E4" title="Leukotriene E4">Leukotriene E<sub>4</sub></a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=BAYu9773&action=edit&redlink=1" class="new" title="BAYu9773 (page does not exist)">BAYu9773</a></li> <li><a href="/w/index.php?title=BAYu9916&action=edit&redlink=1" class="new" title="BAYu9916 (page does not exist)">BAYu9916</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cysteinyl_leukotriene_receptor_E" class="mw-redirect" title="Cysteinyl leukotriene receptor E"><abbr title="Cysteinyl leukotriene receptor E">CysLT<sub>E</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cysteinyl leukotriene receptor E</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <a href="/wiki/Leukotriene_E4" title="Leukotriene E4">Leukotriene E<sub>4</sub></a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Enzyme" title="Enzyme">Enzyme</a><br /><small>(<a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Arachidonate_5-lipoxygenase" title="Arachidonate 5-lipoxygenase"><abbr title="Arachidonate 5-lipoxygenase">5-LOX</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Arachidonate 5-lipoxygenase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=2-TEDC&action=edit&redlink=1" class="new" title="2-TEDC (page does not exist)">2-TEDC</a></li> <li><a href="/wiki/Baicalein" title="Baicalein">Baicalein</a></li> <li><a href="/w/index.php?title=BW-A4C&action=edit&redlink=1" class="new" title="BW-A4C (page does not exist)">BW-A4C</a></li> <li><a href="/w/index.php?title=BW-B70C&action=edit&redlink=1" class="new" title="BW-B70C (page does not exist)">BW-B70C</a></li> <li><a href="/wiki/Caffeic_acid" title="Caffeic acid">Caffeic acid</a></li> <li><a href="/w/index.php?title=Cinnamyl-3,4-dihydroxy-%CE%B1-cyanocinnamate&action=edit&redlink=1" class="new" title="Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (page does not exist)">CDC</a></li> <li><a href="/w/index.php?title=CJ-13610&action=edit&redlink=1" class="new" title="CJ-13610 (page does not exist)">CJ-13610</a></li> <li><a href="/wiki/Curcumin" title="Curcumin">Curcumin</a></li> <li><a href="/wiki/Fenleuton" title="Fenleuton">Fenleuton</a></li> <li><a href="/wiki/Hyperforin" title="Hyperforin">Hyperforin</a></li> <li><a href="/wiki/Hypericum_perforatum" title="Hypericum perforatum"><i>Hypericum perforatum</i> (St. John's Wort)</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid (meclofenamate)</a></li> <li><a href="/wiki/Minocycline" title="Minocycline">Minocycline</a></li> <li><a href="/w/index.php?title=N-Stearoyldopamine&action=edit&redlink=1" class="new" title="N-Stearoyldopamine (page does not exist)">N-Stearoyldopamine</a></li> <li><a href="/w/index.php?title=Timegadine&action=edit&redlink=1" class="new" title="Timegadine (page does not exist)">Timegadine</a></li> <li><a href="/wiki/Zileuton" title="Zileuton">Zileuton</a></li></ul> <ul><li><b><a href="/wiki/Arachidonate_5-lipoxygenase-activating_protein" class="mw-redirect" title="Arachidonate 5-lipoxygenase-activating protein"><abbr title="Arachidonate 5-lipoxygenase-activating protein">FLAP</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Arachidonate 5-lipoxygenase-activating protein</span> inhibitors:</b> <a href="/w/index.php?title=AM-103_(drug)&action=edit&redlink=1" class="new" title="AM-103 (drug) (page does not exist)">AM-103</a></li> <li><a href="/wiki/AM-679_(FLAP_inhibitor)" title="AM-679 (FLAP inhibitor)">AM-679</a></li> <li><a href="/w/index.php?title=BAYx1005&action=edit&redlink=1" class="new" title="BAYx1005 (page does not exist)">BAYx1005</a></li> <li><a href="/w/index.php?title=MK-591&action=edit&redlink=1" class="new" title="MK-591 (page does not exist)">MK-591</a></li> <li><a href="/wiki/MK-886" title="MK-886">MK-886</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Arachidonate_12-lipoxygenase" class="mw-redirect" title="Arachidonate 12-lipoxygenase"><abbr title="Arachidonate 12-lipoxygenase">12-LOX</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Arachidonate 12-lipoxygenase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=2-TEDC&action=edit&redlink=1" class="new" title="2-TEDC (page does not exist)">2-TEDC</a></li> <li><a href="/w/index.php?title=3-Methoxytropolone&action=edit&redlink=1" class="new" title="3-Methoxytropolone (page does not exist)">3-Methoxytropolone</a></li> <li><a href="/wiki/Baicalein" title="Baicalein">Baicalein</a></li> <li><a href="/w/index.php?title=Cinnamyl-3,4-dihydroxy-%CE%B1-cyanocinnamate&action=edit&redlink=1" class="new" title="Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (page does not exist)">CDC</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Arachidonate_15-lipoxygenase" class="mw-redirect" title="Arachidonate 15-lipoxygenase"><abbr title="Arachidonate 15-lipoxygenase">15-LOX</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Arachidonate 15-lipoxygenase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=2-TEDC&action=edit&redlink=1" class="new" title="2-TEDC (page does not exist)">2-TEDC</a></li> <li><a href="/w/index.php?title=Cinnamyl-3,4-dihydroxy-%CE%B1-cyanocinnamate&action=edit&redlink=1" class="new" title="Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (page does not exist)">CDC</a></li> <li><a href="/wiki/Luteolin" title="Luteolin">Luteolin</a></li> <li><a href="/w/index.php?title=PD-146176&action=edit&redlink=1" class="new" title="PD-146176 (page does not exist)">PD-146176</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_A4_hydrolase" class="mw-redirect" title="Leukotriene A4 hydrolase"><abbr title="Leukotriene A4 hydrolase">LTA<sub>4</sub>H</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene A4 hydrolase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Acebilustat&action=edit&redlink=1" class="new" title="Acebilustat (page does not exist)">Acebilustat</a></li> <li><a href="/wiki/Captopril" title="Captopril">Captopril</a></li> <li><a href="/w/index.php?title=DG-051&action=edit&redlink=1" class="new" title="DG-051 (page does not exist)">DG-051</a></li> <li><a href="/wiki/Fosinoprilat" class="mw-redirect" title="Fosinoprilat">Fosinoprilat</a></li> <li><a href="/w/index.php?title=JNJ-26993135&action=edit&redlink=1" class="new" title="JNJ-26993135 (page does not exist)">JNJ-26993135</a></li> <li><a href="/w/index.php?title=SA-6541&action=edit&redlink=1" class="new" title="SA-6541 (page does not exist)">SA-6541</a></li> <li><a href="/w/index.php?title=SC-57461A&action=edit&redlink=1" class="new" title="SC-57461A (page does not exist)">SC-57461A</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_B4_%CF%89-hydroxylase" class="mw-redirect" title="Leukotriene B4 ω-hydroxylase"><abbr title="Leukotriene B4 ω-hydroxylase">LTB<sub>4</sub>H</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene B4 ω-hydroxylase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=17-Octadecynoic_acid&action=edit&redlink=1" class="new" title="17-Octadecynoic acid (page does not exist)">17-Octadecynoic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_C4_synthase" title="Leukotriene C4 synthase"><abbr title="Leukotriene C4 synthase">LTC<sub>4</sub>S</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene C4 synthase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Azelastine" title="Azelastine">Azelastine</a></li> <li><a href="/wiki/MK-886" title="MK-886">MK-886</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_C4_hydrolase" title="Leukotriene C4 hydrolase"><abbr title="Leukotriene C4 hydrolase">LTC<sub>4</sub>H</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene C4 hydrolase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acivicin" title="Acivicin">Acivicin</a></li> <li><a href="/w/index.php?title=Serine-borate_complex&action=edit&redlink=1" class="new" title="Serine-borate complex (page does not exist)">Serine-borate complex</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Leukotriene_D4_hydrolase" class="mw-redirect" title="Leukotriene D4 hydrolase"><abbr title="Leukotriene D4 hydrolase">LTD<sub>4</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Leukotriene D4 hydrolase</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cilastatin" title="Cilastatin">Cilastatin</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Precursors:</b> <a href="/wiki/Linoleic_acid" title="Linoleic acid">Linoleic acid</a></li> <li><a href="/wiki/%CE%93-Linolenic_acid" title="Γ-Linolenic acid">γ-Linolenic acid (gamolenic acid)</a></li> <li><a href="/wiki/Dihomo-%CE%B3-linolenic_acid" title="Dihomo-γ-linolenic acid">Dihomo-γ-linolenic acid</a></li> <li><a href="/wiki/Diglyceride" title="Diglyceride">Diacylglycerol</a></li> <li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li> <li><a href="/wiki/Arachidonic_acid_5-hydroperoxide" title="Arachidonic acid 5-hydroperoxide">5-HPETE (arachidonic acid 5-hydroperoxide)</a></li> <li><a href="/wiki/Leukotriene_A4" title="Leukotriene A4">Leukotriene A<sub>4</sub></a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><i><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></dd> <dd><i><a href="/wiki/Template:Prostanoid_signaling_modulators" title="Template:Prostanoid signaling modulators">Prostanoid signaling modulators</a></i></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r1038841319">.mw-parser-output .tooltip-dotted{border-bottom:1px dotted;cursor:help}</style></div><div 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