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지적재산권이 있는 어세이 파이프라인 - Almac Group
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href="https://so-dc.ixrs.com/adfs/ls/?wa=wsignin1.0&wtrealm=https%3a%2f%2fwww.ixrs.com%2fGlobal%2f&wctx=rm%3d0%26id%3dpassive%26ru%3d%252fGlobal%252f&wct=2023-05-22T15%3a18%3a04Z&whr=http%3a%2f%2fso-dc.ixrs.com%2fadfs%2fservices%2ftrust&wreply=https%3a%2f%2fwww.ixrs.com%2fGlobal%2f">IXRS 로그인</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48488"><a href="https://almacgroup.kr/contact-us/">연락처</a></li> </ul> </li> <li class="top-level menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-46057"><a href="#0">상업화 서비스</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46058"><a href="https://almacgroup.kr/commercial-services/">상업화 서비스</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47654"><a href="https://almacgroup.kr/commercial-services/commercial-manufacturing/">상업화 생산</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47653"><a href="https://almacgroup.kr/commercial-services/commercial-packaging/">상업화 패키징</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47652"><a href="https://almacgroup.kr/commercial-services/pharmaceutical-product-launch/">제품 시판</a></li> </ul> </li> </ul></div> <p class="u-p-x4 u-color-blue2 u-bold u-m-b2 u-hidden@l">General</p> <div class="u-hidden@l"><div class="c-navbar-secondary"><ul id="menu-secondary-top-level" class="menu"><li id="menu-item-46092" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46092"><a href="https://almacgroup.kr/about-us/">회사 소개</a></li> <li id="menu-item-46093" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46093"><a href="https://almacgroup.kr/our-locations/">회사 소재지</a></li> <li id="menu-item-46798" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-46798"><a href="/events/">이벤트</a></li> <li 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menu-item-46287"><a href="#0">일반정보</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46030"><a href="https://almacgroup.kr/about-us/">회사 소개</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46031"><a href="https://almacgroup.kr/our-locations/">회사 소재지</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46558"><a href="https://almacgroup.kr/contact-us/">연락처</a></li> </ul> </li> <li class="menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-46035"><a href="#0">진단 서비스</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46284"><a href="https://almacgroup.kr/almac-diagnostics-overview/">Almac 진단에 대하여</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46036"><a href="https://almacgroup.kr/clinical-trial-solutions/">Almac의 임상시험 해법</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46513"><a href="https://almacgroup.kr/diagnostics-global-laboratories/">글로벌 실험실 및 보유 기술</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46038"><a href="https://almacgroup.kr/diagnostics-bioinformatics-biostatistics-excellence/">지원 서비스</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page current-menu-item page_item page-item-33902 current_page_item menu-item-46039"><a href="https://almacgroup.kr/diagnostics-proprietary-assay-pipeline/" aria-current="page">지적재산권이 있는 어세이 파이프라인</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46042"><a href="https://almacgroup.kr/api-chemical-development/">API 서비스 및 화학물질 개발</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46044"><a href="https://almacgroup.kr/pharmaceutical-development-overview/">의약품 개발</a></li> <li class="top-level menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-46045"><a href="#0">임상 서비스</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46046"><a href="https://almacgroup.kr/clinical-services/">임상 서비스 개요</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47661"><a href="https://almacgroup.kr/clinical-services/clinical-supply-packaging/">임상용품 공급 패키징</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47660"><a href="https://almacgroup.kr/clinical-services/clinical-supply-distribution/">임상용품 배급</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47670"><a href="https://almacgroup.kr/clinical-services/clinical-supply-chain-management/">임상용품 공급망관리(SCM)</a></li> <li class="nav_group menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-47810"><a href="https://almacgroup.kr/clinical-services/flexible-clinical-supply-solutions/">유연한 임상 공급 솔루션</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47815"><a href="https://almacgroup.kr/clinical-services/flexible-clinical-supply-solutions/">유연한 임상 공급 솔루션</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47812"><a href="https://almacgroup.kr/clinical-services/lean-manufacturing/">린(Lean) 생산 방식</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47813"><a href="https://almacgroup.kr/clinical-services/just-in-time-labelling-jtl/">적시 라벨링(JTL)</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47811"><a href="https://almacgroup.kr/clinical-services/almac-adapt-just-in-time-manufacturing-solution/">Almac Adapt™ <br>적시 생산 솔루션</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47674"><a href="https://almacgroup.kr/clinical-services/temperature-management/">차세대 온도 관리</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47676"><a href="https://almacgroup.kr/clinical-services/commercial-drug-procurement/">상업화 약품 조달</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47745"><a href="https://almacgroup.kr/almac-one/">Almac ONE™</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48078"><a href="https://almacgroup.kr/navigating-the-hidden-challenges-of-clinical-packaging-and-labelling/">Webinar: Navigating the Hidden Challenges of Clinical Packaging and labelling</a></li> </ul> </li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-48486"><a href="#0">임상 테크놀러지</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48482"><a href="https://almacgroup.kr/clinical-technologies/">임상 테크놀러지</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48485"><a href="https://almacgroup.kr/clinical-technologies/ixrs3-interactive-response-technology-irt-platform/">IXRS3 플랫폼</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48484"><a href="https://almacgroup.kr/clinical-technologies/irt-startup-modes/">IRT 시작 모드</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48483"><a href="https://almacgroup.kr/clinical-technologies/irt-boosters/">IRT 부스터</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47746"><a href="https://almacgroup.kr/almac-one/">Almac ONE™</a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48487"><a target="_blank" rel="noopener" href="https://so-dc.ixrs.com/adfs/ls/?wa=wsignin1.0&wtrealm=https%3a%2f%2fwww.ixrs.com%2fGlobal%2f&wctx=rm%3d0%26id%3dpassive%26ru%3d%252fGlobal%252f&wct=2023-05-22T15%3a18%3a04Z&whr=http%3a%2f%2fso-dc.ixrs.com%2fadfs%2fservices%2ftrust&wreply=https%3a%2f%2fwww.ixrs.com%2fGlobal%2f">IXRS 로그인</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-48488"><a href="https://almacgroup.kr/contact-us/">연락처</a></li> </ul> </li> <li class="top-level menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-46057"><a href="#0">상업화 서비스</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-46058"><a href="https://almacgroup.kr/commercial-services/">상업화 서비스</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47654"><a href="https://almacgroup.kr/commercial-services/commercial-manufacturing/">상업화 생산</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47653"><a href="https://almacgroup.kr/commercial-services/commercial-packaging/">상업화 패키징</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-47652"><a href="https://almacgroup.kr/commercial-services/pharmaceutical-product-launch/">제품 시판</a></li> </ul> </li> </ul></div> </aside> </div><!-- --><main role="main" class="o-grid__item u-width-9/12 u-width-full@s u-p-l4 u-p-l1@l c-content"> <h1 class="u-p-b4">지적재산권이 있는 어세이 파이프라인</h1> <article> <ul class="c-pipeline__key"> <li class="predictive">예측</li> <li class="prognostic">예후</li> </ul> <div class="video__wrapper video__wrapper--svg" id="pipeline_diagnostics"> <svg version="1.1" id="pipeline" height="420" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 1025 520" enable-background="new 0 0 1025 520" xml:space="preserve"> <a class="hide-on-fallback"> <text transform="matrix(1 0 0 1 12 33.895)" fill="#9DA5AA" 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signature that can identify patients at high-risk for recurrence and/or high risk for cancer-related death.</p> </div> <a href="/diagnostics/internal-dx-pipeline/coldx/" class="c-btn2">View more</a> </article> <article class="pipeline__summary" id="pipe-2"> <h4>Almac’s Prognostic Assay for Prostate Cancer</h4> <div><p>Almac have identified a prognostic gene expression biomarker that prospectively identifies potential metastatic disease in prostate cancer patients.</p> </div> <a href="/diagnostics/internal-dx-pipeline/prostate-dx/" class="c-btn2">View more</a> </article> <article class="pipeline__summary" id="pipe-3"> <h4>Almac’s Predctive Assay for Anti-Angiogenic Agents</h4> <div><p>Almac has identified and validated a powerful gene expression biomarker which identifies a molecular subgroup of patients who may benefit from anti-angiogenic therapy following standard of care chemotherapy.</p> </div> <a href="/diagnostics/internal-dx-pipeline/angio/" class="c-btn2">View more</a> </article> <article class="pipeline__summary" id="pipe-4"> <h4>Almac’s Predictive Assay for DNA Damaging Agents</h4> <div><p>Almac has developed a gene expression assay to predict outcomes following treatment with DNA damaging drugs such as Anthracycline and Cyclophosphamide, novel DNA-damaging therapeutics such as PARP inhibitors as well as Immuno-Oncology agents.</p> </div> <a href="/diagnostics/internal-dx-pipeline/ddrd/" class="c-btn2">View more</a> </article> <article class="pipeline__summary" id="pipe-5"> <h4>Almac’s Predictive Assay for EMT Targeted Agents</h4> <div><p>Almac’s gene expression biomarker utilised to predict response to EMT targeted agents across numerous disease indications which may be affected by the EMT pathway aberrations.ac has identified and validated a powerful gene expression biomarker which identifies a molecular subgroup of patients who may benefit from anti-angiogenic therapy following standard of care chemotherapy.</p> </div> <a href="/diagnostics/portfolio-overview/emt/" class="c-btn2">View more</a> </article> <article class="pipeline__summary" id="pipe-6"> <h4>Almac’s Predictive Assay for Immune Response Agents</h4> <div><p>This gene expression based assay identifies a molecular subgroup of cancers that exhibit activation of immune checkpoint proteins such as PD-L1 and ID01, which results in immune system evasion and cancer cell survival.</p> </div> <a href="/diagnostics/internal-dx-pipeline/immune-response/" class="c-btn2">View more</a> </article> </div> </div> <p><script src="https://secure.leadforensics.com/js/76460.js" type="text/javascript"><span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span></script></p> <p> </p> <h3> </h3> <h3><strong>I-O</strong></h3> <p> </p> <p><strong>면역항암을 위한 Almac 예측 어세이</strong></p> <p>이 유전자 발현 기반 어세이는 암들의 분자 하위그룹을 분별합니다. 이 하위 그룹은 PD-L1과 ID01 같은 면역 점검점 단백질을 활성화시켜 면역 시스템이 작동하지 않게 하는데, 그 결과 암세포가 살아남습니다. Almac은 PD-L1 표적 요법에 반응할 가능성이 높은 환자들을 예측적으로 식별하는 수단으로 이 어세이를 개발하고 있습니다.</p> <p> </p> <p> </p> <h3><strong>혈관종</strong></h3> <p> </p> <p><strong>Almac의 항혈관형성제재에 대한 예측적 어세이</strong></p> <p>Almac은 강력한 유전자 발현 바이오마커를 확인하고 검증했습니다. 이 바이오마커는 표준적인 화학요법에 이어 항혈관형성 요법을 사용시 효과를 볼 수 있는 환자들의 분자 소그룹을 식별합니다.</p> <p> </p> <p> </p> <h3><strong>DDRD (DNA 손상반응 결핍)</strong></h3> <p> </p> <p><strong>Almac의 DNA 손상 제재에 대한 예측적 어세이</strong></p> <p>Almac은 FA/BRCA 경로와 연계된 DNA 손상반응 결핍 종양을 감지하는 유전자 발현 어세이를 개발했습니다. 이 종양은 안트라사이클린 기반 화학요법 같은 DNA 손상 제재에 치료효과를 보이는 것으로 확인되었습니다.</p> <p> </p> <p>이 어세이는 다음 치료 후 결과를 예측할 수 있습니다.</p> <p> </p> <p>1. 안트라사이클린 및 사이클로포스파이드 같은 DNA 손상 제재 <br /> 2. PARP 억제제 등 우수한 DNA 손상 치료법</p> <p> </p> <p>DDRD 어세이는 원래 초기 유방암에 사용할 목적으로 개발되었지만 현재는 다른 질병 분야 – 예컨대, 난소암, 식도암, 직장암 – 에서 효과가 검증되고 있습니다.</p> <p> </p> <p> </p> <h3> <strong>EMT</strong></h3> <p> </p> <p>새로 확인된 분자 하위집단은 티로신 키나아제 수용체(RTKs)와 MARK 경로의 상향 조절이란 특성을 보이는데, 이로 인해 상피-중간엽 전환(Epithelial to Mesenchymal Transition, EMT)과 혈관형성이 활성화됩니다. 이 하위집단은 다수 질병에서 두루 존재하는데 이 집단에 속하는 환자들의 경우 다수 암 – 유방암, 폐암, 대장암, 신장암, 췌장암, 위암, 방광암, 난소암, 흑색종, 교아세포종 – 에 대해 예후를 보이지 않습니다.</p> <p> </p> <p>15 유전자 기호는 FFPE 조직에서 EMT 분자 하위집단에 속하는 환자들을 예측적으로 식별하기 위해 개발되었습니다. 이 유전자 기호는 다음 목적을 위해 환자들을 선별하는데 이용될 수 있습니다.</p> <p> </p> <p>1. MAPK 표적 치료제 (예를 들자면, MEK, p38 억제제) <br /> 2. EMT 표적 치료제 (예를 들자면, AXL 억제제) <br /> 3. RTK 표적 치료제 (예를 들자면, 티로신 키나아제 억제제)</p> <p> </p> <p> </p> <h3><strong>전립선 Dx</strong></h3> <p> </p> <p><strong>중간 위험의 전립선암에 대한 Almac의 예측적 어세이</strong></p> <p>이 70 유전자 어세이는 근본치료 이후 질병의 재발 및/또는 전이의 위험이 높은 환자들을 예측적으로 식별할 수 있습니다. 이 어세이는 중간 위험의 국부적 전립선암을 보이는 환자에게 적합한데 통상의 위험요인 또는 노모그램(예컨대,CAPRA-S/CAPRA)과 함께 사용되어야 합니다. 이 어세이를 이용하면 더 정교한 위험 평가를 할 수 있고 개인에 맞는 치료 전략을 세울 수 있습니다.</p> <p> </p> <p>지금까지 어세이는 가상환경의 3개 데이터 집합과 독립적인 임상적 검증을 위한 2개 환자 집단에서 검증되었습니다. 그 결과 국부적 전립선암을 예측하는 데에는 예후적 의미가 있다는 것이 확인되었습니다 (전립선암은 진행되면서 생화학적 혹은 전이적 질병 징조를 보입니다).</p> <p> </p> <p>Almac은 현재 전립선 Dx를 더욱 개발하여 보조요법의 생존적 효과를 예측하는데 있어서 임상적 효용을 입증할 계획입니다.</p> <p> </p> <p> </p> <h3><strong>ColDx</strong></h3> <p> </p> <p><strong>2~3기 대장암에 대한 Almac의 획기적인 바이오마커</strong></p> <p>이 강력한 다중 기호 실제 사례는 634-탐색 집합 유전자 기호에 관한 것입니다. 이 집합 유전자 기호는 재발 고위험 환자 및/또는 암 관련 사망위험이 높은 사람을 식별해 낼 수 있습니다. 이 집합 유전자 기호는 기존의 알려진 예후적 요소들과는 독립적으로 작용하는데, 이점이 특히 주목됩니다.</p> <p> </p> <p>이 유전자 기호는 2차례 독립 연구에서 검증되었는데, 그 연구결과는 Journal of Clinical Oncology에서 출판되었습니다. 두 연구는 ColDx 어세이가 2기 대장암에서 재발의 위험이 없는 중간 휴식기를 알려주는 독립적이고 중요한 예측치임을 보여줍니다. 이 어세이를 이용하면 전통적인 임상적 위험 마커의 환자 예후를 더 정교하게 해석할 수 있습니다. 이점에서 이 어세이는 잠재적 가치를 갖습니다.</p> <p> </p> <p><noscript>&amp;lt;img src=”https://secure.leadforensics.com/76460.png” /&amp;gt;</noscript></p> <p><a class="c-btn c-btn--red" title="Contact Us" href="/contact-us/">연락처</a></p> </article> <!-- Related news --> <footer class="c-related--diagnostics u-m-t6 u-p-b1 u-p-t4"> </footer> <!-- Reference --> <script> jQuery('.pipe').click(function(){ var url = jQuery(this).data('pagelink'); 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