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The mechanism of action can be explained by the stimulation-induced modulation of impaired network activity. So far, the main use of DBS has been for neurological conditions, such as essential tremor, motor symptoms in Parkinson\u0026amp;amp;#39;s disease, dystonia, epilepsy, and chronic pain. In psychiatry, case series and open studies indicate treatment efficacy of DBS in Gilles de la Tourette syndrome, treatment-resistant obsessive-compulsive disorder, and refractory major depression. Neuroimaging studies have confirmed the effects of DBS on the brain regions implicated in specific neuropsychiatric disorders. It is a well-tolerated method with relatively few serious side effects. Additional well-designed and appropriately powered controlled clinical trial...","author":[{"@context":"https://schema.org","@type":"Person","name":"Pavel Mohr"}],"contributor":[],"dateCreated":"2015-11-07","dateModified":"2015-11-07","headline":"Deep brain stimulation in psychiatry","image":"https://attachments.academia-assets.com/39772811/thumbnails/1.jpg","inLanguage":"en","keywords":["Psychiatry","Deep Brain Stimulation","Treatment Outcome","Humans","Drug Resistance","Mental Disorders"],"publication":"Neuro endocrinology letters","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"cuni"}],"thumbnailUrl":"https://attachments.academia-assets.com/39772811/thumbnails/1.jpg","url":"https://www.academia.edu/17905429/Deep_brain_stimulation_in_psychiatry"}</script><link rel="stylesheet" media="all" 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The mechanism of action can be explained by the stimulation-induced modulation of impaired network activity. So far, the main use of DBS has been for neurological conditions, such as essential tremor, motor symptoms in Parkinson\u0026#39;s disease, dystonia, epilepsy, and chronic pain. In psychiatry, case series and open studies indicate treatment efficacy of DBS in Gilles de la Tourette syndrome, treatment-resistant obsessive-compulsive disorder, and refractory major depression. Neuroimaging studies have confirmed the effects of DBS on the brain regions implicated in specific neuropsychiatric disorders. It is a well-tolerated method with relatively few serious side effects. 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The mechanism of action can be explained by the stimulation-induced modulation of impaired network activity. So far, the main use of DBS has been for neurological conditions, such as essential tremor, motor symptoms in Parkinson&#39;s disease, dystonia, epilepsy, and chronic pain. In psychiatry, case series and open studies indicate treatment efficacy of DBS in Gilles de la Tourette syndrome, treatment-resistant obsessive-compulsive disorder, and refractory major depression. Neuroimaging studies have confirmed the effects of DBS on the brain regions implicated in specific neuropsychiatric disorders. It is a well-tolerated method with relatively few serious side effects. Additional well-designed and appropriately powered controlled clinical trial...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":39772811,"attachmentType":"pdf","workUrl":"https://www.academia.edu/17905429/Deep_brain_stimulation_in_psychiatry"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":39772811,"attachmentType":"pdf","workUrl":"https://www.academia.edu/17905429/Deep_brain_stimulation_in_psychiatry"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="39772811" data-landing_url="https://www.academia.edu/17905429/Deep_brain_stimulation_in_psychiatry" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="63531014" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63531014/Deep_Brain_Stimulation_in_Neurological_and_Psychiatric_Disorders">Deep Brain Stimulation in Neurological and Psychiatric Disorders</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="867501" href="https://imtek.academia.edu/ThomasESchlaepfer">Thomas E. 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ds2-5-body-link" href="https://www.academia.edu/37841874/Deep_brain_stimulation_DBS_at_the_interface_of_neurology_and_psychiatry">Deep brain stimulation (DBS) at the interface of neurology and psychiatry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="59989950" href="https://stanford.academia.edu/NolanWilliams">Nolan Williams</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33000306" href="https://independent.academia.edu/MOkun">Michael Okun</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Investigation, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation (DBS) at the interface of neurology and psychiatry","attachmentId":57844824,"attachmentType":"pdf","work_url":"https://www.academia.edu/37841874/Deep_brain_stimulation_DBS_at_the_interface_of_neurology_and_psychiatry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37841874/Deep_brain_stimulation_DBS_at_the_interface_of_neurology_and_psychiatry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="87959524" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87959524/Deep_brain_stimulation_Treating_neurological_and_psychiatric_disorders_by_modulating_brain_activity">Deep brain stimulation: Treating neurological and psychiatric disorders by modulating brain activity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49474860" href="https://independent.academia.edu/StephenTatter">Stephen Tatter</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroRehabilitation, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Deep brain stimulation: Treating neurological and psychiatric disorders by modulating brain activity","attachmentId":92041638,"attachmentType":"pdf","work_url":"https://www.academia.edu/87959524/Deep_brain_stimulation_Treating_neurological_and_psychiatric_disorders_by_modulating_brain_activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87959524/Deep_brain_stimulation_Treating_neurological_and_psychiatric_disorders_by_modulating_brain_activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="101082271" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101082271/Treatment_of_neurological_and_psychiatric_disorders_with_deep_brain_stimulation_raising_hopes_and_future_challenges">Treatment of neurological and psychiatric disorders with deep brain stimulation; raising hopes and future challenges</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="242526033" href="https://independent.academia.edu/SharifSharifi6">Sharif Sharifi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Basic and clinical neuroscience, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">The technology of Neural Stimulation in recent years has become the focus of the research and treatment, although it has been around for many years. The potential use of stimulating the brain and nerves ranges from the spinal cord stimulation to the implantations of cochlear and bionic eyes with a large discrepancy between the clinical readiness for these various uses. Electrical high-frequency Deep Brain Stimulation (DBS) was developed as an alternative option to treat a few neurological disorders. However, with advancing in surgical procedures, technologies and safeties, the applications of DBS are expanding not only for therapeutic purposes but also for research. Although the exact mechanisms of action/s are not fully understood, the outcome of the ongoing research and clinical trials are promising. DBS has been used to treat the essential tremor since 1997, Parkinson&#39;s disease (PD) since 2002 and dystonia since 2003. 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