CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: GABAA/bezodiazepine receptor complex</title> <meta name="description" content="Search results for: GABAA/bezodiazepine receptor complex"> <meta name="keywords" content="GABAA/bezodiazepine receptor complex"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="GABAA/bezodiazepine receptor complex" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="GABAA/bezodiazepine receptor complex"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 5678</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: GABAA/bezodiazepine receptor complex</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5678</span> 5-[Aryloxypyridyl (or Nitrophenyl)]-4H-1,2,4-Triazoles as Flexible Benzodiazepine Analogs: Synthesis, Receptor Binding Affinity and the Lipophilicity-Dependent Anti-Seizure Onset of Action</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Latifeh%20Navidpour">Latifeh Navidpour</a>, <a href="https://publications.waset.org/abstracts/search?q=Shabnam%20Shabani"> Shabnam Shabani</a>, <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Heidari"> Alireza Heidari</a>, <a href="https://publications.waset.org/abstracts/search?q=Manouchehr%20Bashiri"> Manouchehr Bashiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Azadeh%20Ebrahim-Habibi"> Azadeh Ebrahim-Habibi</a>, <a href="https://publications.waset.org/abstracts/search?q=Soraya%20Shahhosseini"> Soraya Shahhosseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Shafaroodi"> Hamed Shafaroodi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sayyed%20Abbas%20Tabatabai"> Sayyed Abbas Tabatabai</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahsa%20Toolabi"> Mahsa Toolabi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A new series of 5-(2-aryloxy-4-nitrophenyl)-4H-1,2,4-triazoles and 5-(2-aryloxy-3-pyridyl)-4H-1,2,4-triazoles, possessing C-3 thio or alkylthio substituents, was synthesized and evaluated for their benzodiazepine receptor affinity and anti-seizure activity. These analogues revealed similar to significantly superior affinity to GABAA/ benzodiazepine receptor complex (IC50 values of 0.04–4.1 nM), relative to diazepam as the reference drug (IC50 value of 2.4 nM). To determine the onset of anti-seizure activity, the time-dependent effectiveness of i.p. administration of compounds on pentylenetetrazole induced seizure threshold was studied and a very good relationship was observed between the lipophilicity (cLogP) and onset of action of studied analogues (r2 = 0.964). The minimum effective dose of the compounds, determined at the time the analogues showed their highest activity, was demonstrated to be 0.025–0.1 mg/kg, relative to diazepam (0.025 mg/kg). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=1" title="1">1</a>, <a href="https://publications.waset.org/abstracts/search?q=2" title="2">2</a>, <a href="https://publications.waset.org/abstracts/search?q=4-triazole" title="4-triazole">4-triazole</a>, <a href="https://publications.waset.org/abstracts/search?q=flexible%20benzodiazepines" title=" flexible benzodiazepines"> flexible benzodiazepines</a>, <a href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex" title=" GABAA/bezodiazepine receptor complex"> GABAA/bezodiazepine receptor complex</a>, <a href="https://publications.waset.org/abstracts/search?q=onset%20of%20action" title=" onset of action"> onset of action</a>, <a href="https://publications.waset.org/abstracts/search?q=PTZ%20induced%20seizure%20threshold" title=" PTZ induced seizure threshold"> PTZ induced seizure threshold</a> </p> <a href="https://publications.waset.org/abstracts/136418/5-aryloxypyridyl-or-nitrophenyl-4h-124-triazoles-as-flexible-benzodiazepine-analogs-synthesis-receptor-binding-affinity-and-the-lipophilicity-dependent-anti-seizure-onset-of-action" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/136418.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">104</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5677</span> GABARAPL1 (GEC1) mRNA Expression Levels in Patients with Alzheimer's Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Bayram">Ali Bayram</a>, <a href="https://publications.waset.org/abstracts/search?q=Burak%20Uz"> Burak Uz</a>, <a href="https://publications.waset.org/abstracts/search?q=Ilhan%20Dolasik"> Ilhan Dolasik</a>, <a href="https://publications.waset.org/abstracts/search?q=Remzi%20Yi%C4%9Fiter"> Remzi Yiğiter</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The GABARAP (GABAA-receptor-associated protein) family consists of GABARAP, GABARAPL1 (GABARAP-like 1) and GABARAPL2 (GABARAP-like 2). GABARAPL1, like GABARAP, was described to interact with both GABAA receptor and tubulin, and to be involved in intracellular GABAA receptor trafficking and promoting tubulin polymerization. In addition, GABARAPL1 is thought to be involved in various physiological (autophagosome closure, regulation of circadian rhythms) and/or pathological mechanisms (cancer, neurodegeneration). Alzheimer’s disease (AD) is a progressive neuro degenerative disorder characterized with impaired cognitive functions. Disruption of the GABAergic neuro transmission as well as cholinergic and glutamatergic interactions, may also be involved in the pathogenesis of AD. GABARAPL1 presents a regulated tissue expression and is the most expressed gene among the GABARAP family members in the central nervous system. We, herein, conducted a study to investigate the GABARAPL1 mRNA expression levels in patients with AD. 50 patients with AD and 49 control patients were enrolled to the present study. Messenger RNA expression levels of GABARAPL1 were detected by real-time polymerase chain reaction. GABARAPL1 mRNA expression in AD / control patients was 0,495 (95% confidence interval: 0,404-0,607), p= 0,00000002646. Reduced activity of GABARAPL1 gene might play a role, at least partly, in the pathophysiology of AD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title="Alzheimer’s disease">Alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=GABARAPL1" title=" GABARAPL1"> GABARAPL1</a>, <a href="https://publications.waset.org/abstracts/search?q=mRNA%20expression" title=" mRNA expression"> mRNA expression</a>, <a href="https://publications.waset.org/abstracts/search?q=RT-PCR" title=" RT-PCR"> RT-PCR</a> </p> <a href="https://publications.waset.org/abstracts/19029/gabarapl1-gec1-mrna-expression-levels-in-patients-with-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19029.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5676</span> Preparation and Quality Control of a Novel Radiolabeled Complex of 166ho for the Treatment of Somatostatin Receptor Expressing Tumours</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Yousefnia">H. Yousefnia</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Golabi%20Dezfuli"> A. Golabi Dezfuli</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Zolghadri"> S. Zolghadri</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Hosntalab"> M. Hosntalab </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Peptide receptor radionuclide therapy is nowadays used for the treatment of various abnormalities with somatostatin receptors. In this study, 166Ho-DOTATOC was prepared and the best conditions for its radiolabeling was obtained. For this purpose, a certain of DOTATOC was added to a vial containing 166Ho. various experiments by varying ligand concentration, pH, temperature and time were performed to determine the best conditions. Radiochemical purity of the complex was assessed by instant thin layer chromatography method utilizing 0.9% NaCl as the mobile phase. 166Ho-DOTATOC was prepared with radiochemical purity of higher than 95% at the optimized condition (pH=4, temperature: 95° C, time:30 min). In 0.9% NaCl, free Ho cation was developed at Rf of 0.8 while the complex was remained at the front of the paper. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ho-166" title="Ho-166">Ho-166</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroendocrine" title=" neuroendocrine"> neuroendocrine</a>, <a href="https://publications.waset.org/abstracts/search?q=octreotide" title=" octreotide"> octreotide</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20control" title=" quality control"> quality control</a> </p> <a href="https://publications.waset.org/abstracts/32545/preparation-and-quality-control-of-a-novel-radiolabeled-complex-of-166ho-for-the-treatment-of-somatostatin-receptor-expressing-tumours" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32545.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">386</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5675</span> Insights Into Serotonin-Receptor Binding and Stability via Molecular Dynamics Simulations: Key Residues for Electrostatic Interactions and Signal Transduction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arunima%20Verma">Arunima Verma</a>, <a href="https://publications.waset.org/abstracts/search?q=Padmabati%20Mondal"> Padmabati Mondal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Serotonin-receptor binding plays a key role in several neurological and biological processes, including mood, sleep, hunger, cognition, learning, and memory. In this article, we performed molecular dynamics simulation to examine the key residues that play an essential role in the binding of serotonin to the G-protein-coupled 5-HT₁ᴮ receptor (5-HT₁ᴮ R) via electrostatic interactions. An end-point free energy calculation method (MM-PBSA) determines the stability of the 5-HT1B R due to serotonin binding. The single-point mutation of the polar or charged amino acid residues (Asp129, Thr134) on the binding sites and the calculation of binding free energy validate the importance of these residues in the stability of the serotonin-receptor complex. Principal component analysis indicates the serotonin-bound 5-HT1BR is more stabilized than the apo-receptor in terms of dynamical changes. The difference dynamic cross-correlations map shows the correlation between the transmembrane and mini-Go, which indicates signal transduction happening between mini-Go and the receptor. Allosteric communication reveals the key nodes for signal transduction in 5-HT1BR. These results provide useful insights into the signal transduction pathways and mutagenesis study to regulate the functionality of the complex. The developed protocols can be applied to study local non-covalent interactions and long-range allosteric communications in any protein-ligand system for computer-aided drug design. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=allostery" title="allostery">allostery</a>, <a href="https://publications.waset.org/abstracts/search?q=CADD" title=" CADD"> CADD</a>, <a href="https://publications.waset.org/abstracts/search?q=MD%20simulations" title=" MD simulations"> MD simulations</a>, <a href="https://publications.waset.org/abstracts/search?q=MM-PBSA" title=" MM-PBSA"> MM-PBSA</a> </p> <a href="https://publications.waset.org/abstracts/177882/insights-into-serotonin-receptor-binding-and-stability-via-molecular-dynamics-simulations-key-residues-for-electrostatic-interactions-and-signal-transduction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177882.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">87</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5674</span> Optimization and Evaluation of 177lu-Dotatoc as a Potential Agent for Peptide Receptor Radionuclide Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Yousefnia">H. Yousefnia</a>, <a href="https://publications.waset.org/abstracts/search?q=MS.%20Mousavi-Daramoroudi"> MS. Mousavi-Daramoroudi</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Zolghadri"> S. Zolghadri</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Abbasi-Davani"> F. Abbasi-Davani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> High expression of somatostatin receptors on a wide range of human tumours makes them as potential targets for peptide receptor radionuclide tomography. A series of octreotide analogues were synthesized while [DOTA-DPhe1, Tyr3]octreotide (DOTATOC) indicated advantageous properties in tumour models. In this study, 177Lu-DOTATOC was prepared with the radiochemical purity of higher than 99% in 30 min at the optimized condition. Biological behavior of the complex was studied after intravenous injection into the Syrian rats. Major difference uptake was observed compared to 177LuCl3 solution especially in somatostatin receptor-positive tissues such as pancreas and adrenal. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Biodistribution" title="Biodistribution">Biodistribution</a>, <a href="https://publications.waset.org/abstracts/search?q=177Lu" title=" 177Lu"> 177Lu</a>, <a href="https://publications.waset.org/abstracts/search?q=Octreotide" title=" Octreotide"> Octreotide</a>, <a href="https://publications.waset.org/abstracts/search?q=Syrian%20rats" title=" Syrian rats"> Syrian rats</a> </p> <a href="https://publications.waset.org/abstracts/34294/optimization-and-evaluation-of-177lu-dotatoc-as-a-potential-agent-for-peptide-receptor-radionuclide-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34294.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">448</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5673</span> Signaling of Leucine-Rich-Repeat Receptor-Like Kinases in Higher Plants</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Man-Ho%20Oh">Man-Ho Oh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Membrane localized Leucine-Rich-Repeat Receptor-Like Kinases (LRR-RLKs) play crucial roles in plant growth and abiotic/biotic stress responses in higher plants including Arabidopsis and Brassica species. Among several Receptor-Like Kinases (RLKs), Leucine-Rich-Repeat Receptor-Like-Kinases (LRR-RLKs) are the major group of genes that play crucial roles related to growth, development and stress conditions in plant system. Since it is involved in several functional roles, it seems to be very important to investigate their roles in higher plants. We are particularly interested in brassinosteroid (BR) signaling, which is mediated by the BRASSINOSTEROID INSENSITIVE 1 (BRI1) receptor kinase and its co-receptor, BRI1-ASSOCIATED KINASE 1 (BAK1). Autophosphorylation of receptor kinases is recognized to be an important process in activation of signaling in higher plants. Although the plant receptors are generally classified as Ser/Thr protein kinases, many other receptor kinases including BRI1 and BAK1 are shown to autophosphorylate on Tyr residues in addition to Ser/Thr. As an interesting result, we determined that several 14-3-3 regulatory proteins bind to BRI1-CD and are phosphorylated by several receptor kinases in vitro, suggesting that BRI1 is critical for diverse signaling. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autophosphorylation" title="autophosphorylation">autophosphorylation</a>, <a href="https://publications.waset.org/abstracts/search?q=brassinosteroid" title=" brassinosteroid"> brassinosteroid</a>, <a href="https://publications.waset.org/abstracts/search?q=BRASSINOSTEROID%20INSENSITIVE%201" title=" BRASSINOSTEROID INSENSITIVE 1"> BRASSINOSTEROID INSENSITIVE 1</a>, <a href="https://publications.waset.org/abstracts/search?q=BRI1-ASSOCIATED%20KINASE%201" title=" BRI1-ASSOCIATED KINASE 1"> BRI1-ASSOCIATED KINASE 1</a>, <a href="https://publications.waset.org/abstracts/search?q=Leucine-Rich-Repeat%20Receptor-Like%20Kinases%20%28LRR-RLKs%29" title=" Leucine-Rich-Repeat Receptor-Like Kinases (LRR-RLKs)"> Leucine-Rich-Repeat Receptor-Like Kinases (LRR-RLKs)</a> </p> <a href="https://publications.waset.org/abstracts/76545/signaling-of-leucine-rich-repeat-receptor-like-kinases-in-higher-plants" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76545.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">224</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5672</span> An Unbiased Profiling of Immune Repertoire via Sequencing and Analyzing T-Cell Receptor Genes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yi-Lin%20Chen">Yi-Lin Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Sheng-Jou%20Hung"> Sheng-Jou Hung</a>, <a href="https://publications.waset.org/abstracts/search?q=Tsunglin%20Liu"> Tsunglin Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Adaptive immune system recognizes a wide range of antigens via expressing a large number of structurally distinct T cell and B cell receptor genes. The distinct receptor genes arise from complex rearrangements called V(D)J recombination, and constitute the immune repertoire. A common method of profiling immune repertoire is via amplifying recombined receptor genes using multiple primers and high-throughput sequencing. This multiplex-PCR approach is efficient; however, the resulting repertoire can be distorted because of primer bias. To eliminate primer bias, 5’ RACE is an alternative amplification approach. However, the application of RACE approach is limited by its low efficiency (i.e., the majority of data are non-regular receptor sequences, e.g., containing intronic segments) and lack of the convenient tool for analysis. We propose a computational tool that can correctly identify non-regular receptor sequences in RACE data via aligning receptor sequences against the whole gene instead of only the exon regions as done in all other tools. Using our tool, the remaining regular data allow for an accurate profiling of immune repertoire. In addition, a RACE approach is improved to yield a higher fraction of regular T-cell receptor sequences. Finally, we quantify the degree of primer bias of a multiplex-PCR approach via comparing it to the RACE approach. The results reveal significant differences in frequency of VJ combination by the two approaches. Together, we provide a new experimental and computation pipeline for an unbiased profiling of immune repertoire. As immune repertoire profiling has many applications, e.g., tracing bacterial and viral infection, detection of T cell lymphoma and minimal residual disease, monitoring cancer immunotherapy, etc., our work should benefit scientists who are interested in the applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=immune%20repertoire" title="immune repertoire">immune repertoire</a>, <a href="https://publications.waset.org/abstracts/search?q=T-cell%20receptor" title=" T-cell receptor"> T-cell receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=5%27%20RACE" title=" 5' RACE"> 5' RACE</a>, <a href="https://publications.waset.org/abstracts/search?q=high-throughput%20sequencing" title=" high-throughput sequencing"> high-throughput sequencing</a>, <a href="https://publications.waset.org/abstracts/search?q=sequence%20alignment" title=" sequence alignment"> sequence alignment</a> </p> <a href="https://publications.waset.org/abstracts/88972/an-unbiased-profiling-of-immune-repertoire-via-sequencing-and-analyzing-t-cell-receptor-genes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/88972.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">194</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5671</span> Conformational Switch of hRAGE upon Self-Association</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ikhlas%20Ahmed">Ikhlas Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamillah%20Zamoon"> Jamillah Zamoon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The human receptor for advanced glycation end product is a plasma membrane receptor with an intrinsically disordered region. The protein consists of three extracellular domains, a single membrane spanning transmembrane domain, and a cytosolic domain which is intrinsically disordered and responsible for signaling. The disordered nature of the cytosolic domain allows it to be dynamic in solution. This receptor self-associates to higher forms. The association is triggered by ligand, metal or by the extracellular domain. Fluorescence spectroscopy technique is used to test the self-association of the different concentrations of the cytosolic domain. This work has concluded that the cytosolic domain of this receptor also self-associates. Moreover, the self-association does not require ligand or metal. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluorescence%20spectroscopy" title="fluorescence spectroscopy">fluorescence spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=hRAGE" title=" hRAGE"> hRAGE</a>, <a href="https://publications.waset.org/abstracts/search?q=IDP" title=" IDP"> IDP</a>, <a href="https://publications.waset.org/abstracts/search?q=Self-association" title=" Self-association"> Self-association</a> </p> <a href="https://publications.waset.org/abstracts/44509/conformational-switch-of-hrage-upon-self-association" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44509.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5670</span> Using of Bimolecular Fluorescence Complementation (BiFC) Assays to Study Homo and/ or Heterodimerization of Laminin Receptor 37 LRP/ 67 LR with Galectin-3</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fulwah%20Alqahtani">Fulwah Alqahtani</a>, <a href="https://publications.waset.org/abstracts/search?q=Jafar%20Mahdavi"> Jafar Mahdavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lee%20Weldon"> Lee Weldon</a>, <a href="https://publications.waset.org/abstracts/search?q=Nick%20Holliday"> Nick Holliday</a>, <a href="https://publications.waset.org/abstracts/search?q=Dlawer%20Ala%27Aldeen"> Dlawer Ala'Aldeen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There are two isoforms of laminin receptor; monomeric 37 kDa laminin receptor precursor (37 LRP) and mature 67 kDa laminin receptor (67 LR). The relationship between the 67 LR and its precursor 37 LRP is not completely understood, but previous observations have suggested that 37 LRP can undergo homo- and/or hetero- dimerization with Galectin-3 (Gal-3) to form mature 67 LR. Gal-3 is the only member of the chimera-type group of galectins, and has one C-terminal carbohydrate recognition domain (CRD) that is responsible for binding the ß-galactoside moieties of mono- or oligosaccharides on several host and microbial molecules. The aim of this work was to investigate homo- and hetero-dimerization among the 37 LRP and Gal-3 to form mature 67 LR in mammalian cells using bimolecular fluorescence complementation (BiFC). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=37%20LRP" title="37 LRP">37 LRP</a>, <a href="https://publications.waset.org/abstracts/search?q=67%20LR" title=" 67 LR"> 67 LR</a>, <a href="https://publications.waset.org/abstracts/search?q=Gal-3" title=" Gal-3"> Gal-3</a>, <a href="https://publications.waset.org/abstracts/search?q=BiFC" title=" BiFC"> BiFC</a> </p> <a href="https://publications.waset.org/abstracts/15423/using-of-bimolecular-fluorescence-complementation-bifc-assays-to-study-homo-and-or-heterodimerization-of-laminin-receptor-37-lrp-67-lr-with-galectin-3" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15423.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">504</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5669</span> Inhibitory Effects of PPARγ Ligand, KR-62980, on Collagen-Stimulated Platelet Activation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Su%20Bin%20Wang">Su Bin Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Hee%20Ahn"> Jin Hee Ahn</a>, <a href="https://publications.waset.org/abstracts/search?q=Tong-Shin%20Chang"> Tong-Shin Chang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The peroxisome proliferator-activated receptors (PPARs) are member of nuclear receptor superfamily that act as a ligand-activated transcription factors. Although platelets lack a nucleus, previous studies have shown that PPARγ agonists, rosiglitazone, inhibited platelet activation induced by collagen. In this study, we investigated the inhibitory effects of KR-62980, a newly synthesized PPARγ agonist, on collagen receptor-stimulated platelet activation. The specific tyrosine phosphorylations of key components (Syk, Vav1, Btk and PLCγ2) for collagen receptor signaling pathways were suppressed by KR-62980. KR-62980 also attenuated downstream responses including cytosolic calcium elevation, P-selectin surface exposure, and integrin αIIbβ3 activation. PPARγ was found to associate with multiple proteins within the LAT signaling complex in collagen-stimulated platelets. This association was prevented by KR-62980, indicating a potential mechanism for PPARγ function in collagen-stimulated platelet activation. Furthermore, KR-62980 inhibited platelet aggregation and adhesion in response to collagen in vitro and prolonged in vivo thrombotic response in carotid arteries of mice. Collectively, these data suggest that KR-62980 inhibits collagen-stimulated platelet activation and thrombus formation through modulating the collagen receptor signaling pathways. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=KR-62980" title="KR-62980">KR-62980</a>, <a href="https://publications.waset.org/abstracts/search?q=PPAR%CE%B3" title=" PPARγ"> PPARγ</a>, <a href="https://publications.waset.org/abstracts/search?q=antiplatelet" title=" antiplatelet"> antiplatelet</a>, <a href="https://publications.waset.org/abstracts/search?q=thrombosis" title=" thrombosis"> thrombosis</a> </p> <a href="https://publications.waset.org/abstracts/47842/inhibitory-effects-of-ppargh-ligand-kr-62980-on-collagen-stimulated-platelet-activation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47842.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5668</span> Role of Imaging in Predicting the Receptor Positivity Status in Lung Adenocarcinoma: A Chapter in Radiogenomics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sonal%20Sethi">Sonal Sethi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mukesh%20Yadav"> Mukesh Yadav</a>, <a href="https://publications.waset.org/abstracts/search?q=Abhimanyu%20Gupta"> Abhimanyu Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The upcoming field of radiogenomics has the potential to upgrade the role of imaging in lung cancer management by noninvasive characterization of tumor histology and genetic microenvironment. Receptor positivity like epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) genotyping are critical in lung adenocarcinoma for treatment. As conventional identification of receptor positivity is an invasive procedure, we analyzed the features on non-invasive computed tomography (CT), which predicts the receptor positivity in lung adenocarcinoma. Retrospectively, we did a comprehensive study from 77 proven lung adenocarcinoma patients with CT images, EGFR and ALK receptor genotyping, and clinical information. Total 22/77 patients were receptor-positive (15 had only EGFR mutation, 6 had ALK mutation, and 1 had both EGFR and ALK mutation). Various morphological characteristics and metastatic distribution on CT were analyzed along with the clinical information. Univariate and multivariable logistic regression analyses were used. On multivariable logistic regression analysis, we found spiculated margin, lymphangitic spread, air bronchogram, pleural effusion, and distant metastasis had a significant predictive value for receptor mutation status. On univariate analysis, air bronchogram and pleural effusion had significant individual predictive value. Conclusions: Receptor positive lung cancer has characteristic imaging features compared with nonreceptor positive lung adenocarcinoma. Since CT is routinely used in lung cancer diagnosis, we can predict the receptor positivity by a noninvasive technique and would follow a more aggressive algorithm for evaluation of distant metastases as well as for the treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lung%20cancer" title="lung cancer">lung cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=multidisciplinary%20cancer%20care" title=" multidisciplinary cancer care"> multidisciplinary cancer care</a>, <a href="https://publications.waset.org/abstracts/search?q=oncologic%20imaging" title=" oncologic imaging"> oncologic imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=radiobiology" title=" radiobiology"> radiobiology</a> </p> <a href="https://publications.waset.org/abstracts/129528/role-of-imaging-in-predicting-the-receptor-positivity-status-in-lung-adenocarcinoma-a-chapter-in-radiogenomics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/129528.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5667</span> Analysis of Cannabinol and Cannabidiol affinity with GBRA1</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamid%20Hossein%20Khezri">Hamid Hossein Khezri</a>, <a href="https://publications.waset.org/abstracts/search?q=Afsaneh%20Javdani-Mallak"> Afsaneh Javdani-Mallak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Cannabidiol (CBD) is one of the members of cannabinoid compounds found in cannabis. CBD and Cannabinol (CBN), as the other extract of plant Cannabis were able to reduce myofascial pain in rats with immunosuppressive and anti-inflammatory activities. In this study, we accomplished protein-protein BLAST, and the sequence was found to be for Gamma-aminobutyric acid receptor subunit alpha-1 (GBRA1) chain A and its 3D structure was subsequently downloaded from Protein Data Bank. The structures of the ligands, cannabinol, and cannabidiol, were obtained from PubChem. After the necessary process of the obtained files, AutoDock Vina was used to perform molecular docking. Docking between the ligands and GBRA1 chain A revealed that cannabinol has a higher affinity to GBRA1 (binding energy = -7.5 kcal/mol) compared to cannabidiol (binding energy = -6.5 kcal/mol). Furthermore, cannabinol seems to be able to interact with 10 residues of the protein, out of which 3 are in the neurotransmitter-gated ion-channel transmembrane domain of GBRA1, whereas cannabidiol interacts with two other residues. Although the results of this project do not indicate the activating /or inhibitory capability of the studied compounds, it suggests that cannabinol can act as a relatively strong ligand for GBRA1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=protein-ligand%20docking" title="protein-ligand docking">protein-ligand docking</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabinol" title=" cannabinol"> cannabinol</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabidiol" title=" cannabidiol"> cannabidiol</a>, <a href="https://publications.waset.org/abstracts/search?q=GBRA1" title=" GBRA1"> GBRA1</a> </p> <a href="https://publications.waset.org/abstracts/155774/analysis-of-cannabinol-and-cannabidiol-affinity-with-gbra1" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155774.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">110</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5666</span> Capsaicin Derivatives Enhanced Activity of α1β2γ2S-Aminobutyric Acid Type a Receptor Expressed in Xenopus laevis Oocytes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jia%20H.%20Wong">Jia H. Wong</a>, <a href="https://publications.waset.org/abstracts/search?q=Jingli%20Zhang"> Jingli Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Habsah%20Mohamad"> Habsah Mohamad</a>, <a href="https://publications.waset.org/abstracts/search?q=Iswatun%20H.%20Abdullah%20Ripain"> Iswatun H. Abdullah Ripain</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Bilal"> Muhammad Bilal</a>, <a href="https://publications.waset.org/abstracts/search?q=Amelia%20J.%20Lloyd"> Amelia J. Lloyd</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20A.%20Mohamed%20Yusoff"> Abdul A. Mohamed Yusoff</a>, <a href="https://publications.waset.org/abstracts/search?q=Jafri%20M.%20Abdullah"> Jafri M. Abdullah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epilepsy is one of the most common neurological diseases affecting more than 50 million of people worldwide. Epilepsy is a state of recurrent, spontaneous seizures with multiple syndromes and symptoms of different causes of brain dysfunction, prognosis, and treatments; characterized by transient, occasional and stereotyped interruptions of behavior whereby the excitatory-inhibitory activities within the central nervous system (CNS) are thrown out of balance due to various kinds of interferences. The goal of antiepileptic treatment is to enable patients to be free from seizures or to achieve control of seizures through surgical treatment and/or pharmacotherapy. Pharmacotherapy through AED plays an important role especially in countries with epilepsy treatment gap due to costs and availability of health facilities, skills and resources, yet there are about one-third of the people with epilepsy have drug-resistant seizures. Hence, this poses considerable challenges to the healthcare system and the effort in providing cost-effective treatment as well as the search for alternatives to treatment and management of epilepsy. Enhancement of γ-aminobutyric acid (GABA)-mediated inhibitory neurotransmission is one of the key mechanisms of actions of antiepileptic drugs. GABA type > a receptors (GABAAR) are ligand-gated ion channels that mediate rapid inhibitory neurotransmission upon the binding of GABA with a heteropentameric structure forming a central pore that is permeable to the influx of chloride ions in its activated state. The major isoform of GABAA receptors consists of two α1, two β2, and one γ2 subunit. It is the most abundantly expressed combinations in the brain and the most commonly researched through Xenopus laevis oocytes. With the advancing studies on ethnomedicine and traditional treatments using medicinal plants, increasing evidence reveal that spice and herb plants with medicinal properties play an important role in the treatment of ailments within communities across different cultures. Capsaicin is the primary natural capsaicinoid in hot peppers of plant genus Capsicum, consist of an aromatic ring, an amide linkage and a hydrophobic side chain. The study showed that capsaicins conferred neuroprotection in status epilepticus mouse models through anti-ictogenic, hypothermic, antioxidative, anti-inflammatory, and anti-apoptotic actions in a dose-dependent manner. In this study, five capsaicin derivatives were tested for their ability to increase the GABA-induced chloride current on α1β2γ2S of GABAAR expressed on Xenopus laevis oocytes using the method of two-microelectrode voltage clamp. Two of the capsaicin derivatives, IS5 (N-(4-hydroxy-3-methoxybenzyl)-3-methylbutyramide) and IS10 (N-(4-hydroxy-3-methoxybenzyl)-decanamide) at a concentration of 30µM were able to significantly increase the GABA-induced chloride current with p=0.002 and p=0.026 respectively. This study were able to show the enhancement effect of two capsaicin derivatives with moderate length of hydrocarbon chain on this receptor subtype, revealing the promising inhibitory activity of capsaicin derivatives through enhancement of GABA-induced chloride current and further investigations should be carried out to verify its antiepileptic effects in animal models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B11%CE%B22%CE%B32%20GABAA%20receptors" title="α1β2γ2 GABAA receptors">α1β2γ2 GABAA receptors</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B11%CE%B22%CE%B32S" title=" α1β2γ2S"> α1β2γ2S</a>, <a href="https://publications.waset.org/abstracts/search?q=antiepileptic" title=" antiepileptic"> antiepileptic</a>, <a href="https://publications.waset.org/abstracts/search?q=capsaicin%20derivatives" title=" capsaicin derivatives"> capsaicin derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=two-microelectrode%20voltage%20clamp" title=" two-microelectrode voltage clamp"> two-microelectrode voltage clamp</a>, <a href="https://publications.waset.org/abstracts/search?q=Xenopus%20laevis%20oocytes" title=" Xenopus laevis oocytes"> Xenopus laevis oocytes</a> </p> <a href="https://publications.waset.org/abstracts/38140/capsaicin-derivatives-enhanced-activity-of-a1v2gh2s-aminobutyric-acid-type-a-receptor-expressed-in-xenopus-laevis-oocytes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38140.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5665</span> Analysis of Cannabinoid and Cannabidiol Affinity with GABRA1</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamid%20Hossein%20Khezri">Hamid Hossein Khezri</a>, <a href="https://publications.waset.org/abstracts/search?q=Afsaneh%20Javdani-Mallak"> Afsaneh Javdani-Mallak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Cannabidiol (CBD) is one of the members of cannabinoid compounds found in cannabis. CBD and Cannabinol (CBN), as the other extract of plant Cannabis, were able to reduce myofascial pain in rats with immunosuppressive and anti-inflammatory activities. In this study, we accomplished protein-protein BLAST and the sequence was found to be for Gamma-aminobutyric acid receptor subunit alpha-1 (GBRA1) chain A and its 3D structure was subsequently downloaded from Protein Data Bank. The structures of the ligands cannabinol and cannabidiol were obtained from PubChem. After a necessary process of the obtained files, AutoDock Vina was used to performing molecular docking. Docking between the ligands and GBRA1 chain A revealed that cannabinol has a higher affinity to GBRA1 (binding energy = -7.5 kcal/mol) compared to cannabidiol (binding energy = -6.5 kcal/mol). Furthermore, cannabinol seems to be able to interact with 10 residues of the protein, out of which 3 are in the neurotransmitter-gated ion-channel transmembrane domain of GBRA1, whereas cannabidiol interacts with two other residues. Although the results of this project do not indicate the activating /or inhibitory capability of the studied compounds, it suggests that cannabinol can act as a relatively strong ligand for GBRA1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=protein-ligand%20docking" title="protein-ligand docking">protein-ligand docking</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabinol" title=" cannabinol"> cannabinol</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabidiol" title=" cannabidiol"> cannabidiol</a>, <a href="https://publications.waset.org/abstracts/search?q=GBRA1" title=" GBRA1"> GBRA1</a> </p> <a href="https://publications.waset.org/abstracts/155758/analysis-of-cannabinoid-and-cannabidiol-affinity-with-gabra1" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155758.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">118</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5664</span> Produced Gas Conversion of Microwave Carbon Receptor Reforming</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Young%20Nam%20Chun">Young Nam Chun</a>, <a href="https://publications.waset.org/abstracts/search?q=Mun%20Sup%20Lim"> Mun Sup Lim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Carbon dioxide and methane, the major components of biomass pyrolysis/gasification gas and biogas, top the list of substances that cause climate change, but they are also among the most important renewable energy sources in modern society. The purpose of this study is to convert carbon dioxide and methane into high-quality energy using char and commercial activated carbon obtained from biomass pyrolysis as a microwave receptor. The methane reforming process produces hydrogen and carbon. This carbon is deposited in the pores of the microwave receptor and lowers catalytic activity, thereby reducing the methane conversion rate. The deposited carbon was removed by carbon gasification due to the supply of carbon dioxide, which solved the problem of microwave receptor inactivity. In particular, the conversion rate remained stable at over 90% when the ratio of carbon dioxide to methane was 1:1. When the reforming results of carbon dioxide and methane were compared after fabricating nickel and iron catalysts using commercial activated carbon as a carrier, the conversion rate was higher in the iron catalyst than in the nickel catalyst and when no catalyst was used.  <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microwave" title="microwave">microwave</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20reforming" title=" gas reforming"> gas reforming</a>, <a href="https://publications.waset.org/abstracts/search?q=greenhouse%20gas" title=" greenhouse gas"> greenhouse gas</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave%20receptor" title=" microwave receptor"> microwave receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=catalyst" title=" catalyst"> catalyst</a> </p> <a href="https://publications.waset.org/abstracts/77831/produced-gas-conversion-of-microwave-carbon-receptor-reforming" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77831.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">379</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5663</span> On the Thermodynamics of Biological Cell Adhesion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ben%20Nadler">Ben Nadler</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cell adhesion plays a vital role in many cell activities. The motivation to model cell adhesion is to study important biological processes, such as cell spreading, cell aggregation, tissue formation, and cell adhesion, which are very challenging to study by experimental methods alone. This study provides important insight into cell adhesion, which can lead to improve regenerative medicine and tissue formation techniques. In this presentation the biological cells adhesion is mediated by receptors–ligands binding and the diffusivity of the receptor on the cell membrane surface. The ability of receptors to diffuse on the cell membrane surface yields a very unique and complicated adhesion mechanism, which is exclusive to cells. The phospholipid bilayer, which is the main component in the cell membrane, shows fluid-like behavior associated with the molecules’ diffusivity. The biological cell is modeled as a fluid-like membrane with negligible bending stiffness enclosing the cytoplasm fluid. The in-plane mechanical behavior of the cell membrane is assumed to depend only on the area change, which is motivated by the fluidity of the phospholipid bilayer. In addition, the presence of receptors influences on the local mechanical properties of the cell membrane is accounted for by including stress-free area change, which depends on the receptor density. Based on the physical properties of the receptors and ligands the attraction between the receptors and ligands is modeled as a charged-nonpolar which is a noncovalent interaction. Such interaction is a short-range type, which decays fast with distance. The mobility of the receptor on the cell membrane is modeled using the diffusion equation and Fick’s law is used to model the receptor–receptor interactions. The resultant interaction force, which includes receptor–ligand and receptor–receptor interaction, is decomposed into tangential part, which governs the receptor diffusion, and normal part, which governs the cell deformation and adhesion. The formulation of the governing equations and numerical simulations will be presented. Analysis of the adhesion characteristic and properties are discussed. The roles of various thermomechanical properties of the cell, receptors and ligands on the cell adhesion are investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cell%20adhesion" title="cell adhesion">cell adhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20membrane" title=" cell membrane"> cell membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=receptor-ligand%20interaction" title=" receptor-ligand interaction"> receptor-ligand interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=receptor%20diffusion" title=" receptor diffusion"> receptor diffusion</a> </p> <a href="https://publications.waset.org/abstracts/37546/on-the-thermodynamics-of-biological-cell-adhesion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37546.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">342</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5662</span> Study of Functional Relevant Conformational Mobility of β-2 Adrenoreceptor by Means of Molecular Dynamics Simulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=G.%20V.%20Novikov">G. V. Novikov</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20S.%20Sivozhelezov"> V. S. Sivozhelezov</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20S.%20Kolesnikov"> S. S. Kolesnikov</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20V.%20Shaitan"> K. V. Shaitan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study reports about the influence of binding of orthosteric ligands as well as point mutations on the conformational dynamics of β-2-adrenoreceptor. Using molecular dynamics simulation we found that there was a little fraction of active states of the receptor in its apo (ligand free) ensemble corresponded to its constitutive activity. Analysis of MD trajectories indicated that such spontaneous activation of the receptor is accompanied by the motion in intracellular part of its alpha-helices. Thus receptor’s constitutive activity directly results from its conformational dynamics. On the other hand the binding of a full agonist resulted in a significant shift of the initial equilibrium towards its active state. Finally, the binding of the inverse agonist stabilized the receptor in its inactive state. It is likely that the binding of inverse agonists might be a universal way of constitutive activity inhibition in vivo. Our results indicate that ligand binding redistribute pre-existing conformational degrees of freedom (in accordance to the Monod-Wyman-Changeux-Model) of the receptor rather than cause induced fit in it. Therefore, the ensemble of biologically relevant receptor conformations is encoded in its spatial structure, and individual conformations from that ensemble might be used by the cell in conformity with the physiological behaviour. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=seven-transmembrane%20receptors" title="seven-transmembrane receptors">seven-transmembrane receptors</a>, <a href="https://publications.waset.org/abstracts/search?q=constitutive%20activity" title=" constitutive activity"> constitutive activity</a>, <a href="https://publications.waset.org/abstracts/search?q=activation" title=" activation"> activation</a>, <a href="https://publications.waset.org/abstracts/search?q=x-ray%20crystallography" title=" x-ray crystallography"> x-ray crystallography</a>, <a href="https://publications.waset.org/abstracts/search?q=principal%20component%20analysis" title=" principal component analysis"> principal component analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulation" title=" molecular dynamics simulation"> molecular dynamics simulation</a> </p> <a href="https://publications.waset.org/abstracts/5618/study-of-functional-relevant-conformational-mobility-of-v-2-adrenoreceptor-by-means-of-molecular-dynamics-simulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/5618.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5661</span> Targeting Trypanosoma brucei Using Antibody Drug Conjugates against the Transferrin Receptor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Camilla%20Trevor">Camilla Trevor</a>, <a href="https://publications.waset.org/abstracts/search?q=Matthew%20K.%20Higgins"> Matthew K. Higgins</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrea%20Gonzalez-Munoz"> Andrea Gonzalez-Munoz</a>, <a href="https://publications.waset.org/abstracts/search?q=Mark%20Carrington"> Mark Carrington</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Trypanosomiasis is a devastating disease affecting both humans and livestock in sub-Saharan Africa. The diseases are caused by infection with African trypanosomes, protozoa transmitted by tsetse flies. Treatment currently relies on the use of chemotherapeutics with ghastly side effects. Here, we describe the development of effective antibody-drug conjugates that target the T. brucei transferrin receptor. The receptor is essential for trypanosome growth in a mammalian host but there are approximately 12 variants of the transferrin receptor in the genome. Two of the most divergent variants were used to generate recombinant monoclonal immunoglobulin G using phage display and we identified cross-reactive antibodies that bind both variants using phage ELISA, fluorescence resonance energy transfer assays and surface plasmon resonance. Fluorescent antibodies were used to demonstrate uptake into trypanosomes in culture. Toxin-conjugated antibodies were effective at killing trypanosomes at sub-nanomolar concentrations. The approach of using antibody-drug conjugates has proven highly effective. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibody-drug%20conjugates" title="antibody-drug conjugates">antibody-drug conjugates</a>, <a href="https://publications.waset.org/abstracts/search?q=phage%20display" title=" phage display"> phage display</a>, <a href="https://publications.waset.org/abstracts/search?q=transferrin%20receptor" title=" transferrin receptor"> transferrin receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=trypanosomes" title=" trypanosomes"> trypanosomes</a> </p> <a href="https://publications.waset.org/abstracts/99250/targeting-trypanosoma-brucei-using-antibody-drug-conjugates-against-the-transferrin-receptor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99250.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5660</span> Correlation of Leptin with Clinico-Pathological Features of Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saad%20Al-Shibli">Saad Al-Shibli</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20Amjad"> Nasser Amjad</a>, <a href="https://publications.waset.org/abstracts/search?q=Muna%20Al%20Kubaisi"> Muna Al Kubaisi</a>, <a href="https://publications.waset.org/abstracts/search?q=Norra%20Harun"> Norra Harun</a>, <a href="https://publications.waset.org/abstracts/search?q=Shaikh%20Mizan"> Shaikh Mizan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Leptin is a multifunctional hormone produced mainly by adipocyte. Leptin and its receptor have long been found associated with breast cancer. The main aim of this study is to investigate the correlation between Leptin/Leptin receptor and the clinicopathological features of breast cancer. Blood samples for ELISA, tissue samples from tumors and adjacent breast tissue were taken from 51 women with breast cancer with a control group of 40 women with a negative mammogram. Leptin and Leptin receptor in the tissues were estimated by immunohistochemistry (IHC). They were localized at the subcellular level by immunocytochemistry using transmission electron microscopy (TEM). Our results showed significant difference in serum leptin level between control and the patient group, but no difference between pre and post-operative serum leptin levels in the patient group. By IHC, we found that the majority of the breast cancer cells studied, stained positively for leptin and leptin receptors with co-expression of leptin and its receptors. No significant correlation was found between leptin/leptin receptors expression with the race, menopausal status, lymph node metastasis, estrogen receptor expression, progesterone receptor expression, HER2 expression and tumor size. Majority of the patients with distant metastasis were associated with high leptin and leptin receptor expression. TEM views both Leptin and Leptin receptor were found highly concentrated within and around the nucleus of the cancer breast cells, indicating nucleus is their principal seat of actions while the adjacent breast epithelial cells showed that leptin gold particles are scattered all over the cell with much less than that of the cancerous cells. However, presence of high concentration of leptin does not necessarily prove its over-expression, because it could be internalized from outside by leptin receptor in the cells. In contrast, leptin receptor is definitely over-expressed in the ductal breast cancer cells. We conclude that reducing leptin levels, blocking its downstream tissue specific signal transduction, and/or blocking the upstream leptin receptor pathway might help in prevention and therapy of breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=expression" title=" expression"> expression</a>, <a href="https://publications.waset.org/abstracts/search?q=leptin" title=" leptin"> leptin</a>, <a href="https://publications.waset.org/abstracts/search?q=leptin%20receptors" title=" leptin receptors"> leptin receptors</a> </p> <a href="https://publications.waset.org/abstracts/99477/correlation-of-leptin-with-clinico-pathological-features-of-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99477.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">140</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5659</span> New Active Dioxin Response Element Sites in Regulatory Region of Human and Viral Genes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ilya%20B.%20Tsyrlov">Ilya B. Tsyrlov</a>, <a href="https://publications.waset.org/abstracts/search?q=Dmitry%20Y.%20Oshchepkov"> Dmitry Y. Oshchepkov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A computational search for dioxin response elements (DREs) in genes of proteins comprising the Ah receptor (AhR) cytosolic core complex was performed by highly efficient tool SITECON. Eventually, the following number of new DREs in 5’flanking region was detected by SITECON: one in AHR gene, five in XAP2, eight in HSP90AA1, and three in HSP90AB1 genes. Numerous DREs found in genes of AhR and AhR cytosolic complex members would shed a light on potential mechanisms of expression, the stoichiometry of unliganded AhR core complex, and its degradation vs biosynthesis dynamics resulted from treatment of target cells with the AhR most potent ligand, 2,3,7,8-TCDD. With human viruses, reduced susceptibility to TCDD of geneencoding HIV-1 P247 was justified by the only potential DRE determined in gag gene encoding HIV-1 P24 protein, whereas the regulatory region of CMV genes encoding IE gp/UL37 has five potent DRE, 1.65 kb/UL36 – six DRE, pp65 and pp71 – each has seven DRE, and pp150 – ten DRE. Also, from six to eight DRE were determined with SITECON in the regulatory region of HSV-1 IE genes encoding tegument proteins, UL36 and UL37, and of UL19 gene encoding bindingglycoprotein C (gC). So, TCDD in the low picomolar range may activate in human cells AhR: Arnt transcription pathway that triggers CMV and HSV-1 reactivation by binding to numerous promoter DRE within immediate-early (IE) genes UL37 and UL36, thus committing virus to the lytic cycle. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dioxin%20response%20elements" title="dioxin response elements">dioxin response elements</a>, <a href="https://publications.waset.org/abstracts/search?q=Ah%20receptor" title=" Ah receptor"> Ah receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=AhR%3A%20Arnt%20transcription%20pathway" title=" AhR: Arnt transcription pathway"> AhR: Arnt transcription pathway</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20and%20viral%20genes" title=" human and viral genes"> human and viral genes</a> </p> <a href="https://publications.waset.org/abstracts/150381/new-active-dioxin-response-element-sites-in-regulatory-region-of-human-and-viral-genes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/150381.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">104</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5658</span> Plant Mediated RNAi Approach to Knock Down Ecdysone Receptor Gene of Colorado Potato Beetle</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tahira%20Hussain">Tahira Hussain</a>, <a href="https://publications.waset.org/abstracts/search?q=Ilhom%20Rahamkulov"> Ilhom Rahamkulov</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Aasim"> Muhammad Aasim</a>, <a href="https://publications.waset.org/abstracts/search?q=Ugur%20Pirlak"> Ugur Pirlak</a>, <a href="https://publications.waset.org/abstracts/search?q=Emre%20Aksoy"> Emre Aksoy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehmet%20Emin%20Caliskan"> Mehmet Emin Caliskan</a>, <a href="https://publications.waset.org/abstracts/search?q=Allah%20Bakhsh"> Allah Bakhsh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> RNA interference (RNAi) has proved its usefulness in functional genomic research on insects recently and is considered potential strategy in crop improvement for the control of insect pests. The different insect pests incur significant losses to potato yield worldwide, Colorado Potato Beetle (CPB) being most notorious one. The present study focuses to knock down highly specific 20-hydroxyecdysone hormone-receptor complex interaction by using RNAi approach to silence Ecdysone receptor (EcR) gene of CPB in transgenic potato plants expressing dsRNA of EcR gene. The partial cDNA of Ecdysone receptor gene of CPB was amplified using specific primers in sense and anti-sense orientation and cloned in pRNAi-GG vector flanked by an intronic sequence (pdk). Leaf and internodal explants of Lady Olympia, Agria and Granola cultivars of potato were infected with Agrobacterium strain LBA4404 harboring plasmid pRNAi-CPB, pRNAi-GFP (used as control). Neomycin phosphotransferase (nptII) gene was used as a plant selectable marker at a concentration of 100 mg L⁻¹. The primary transformants obtained have shown proper integration of T-DNA in plant genome by standard molecular analysis like polymerase chain reaction (PCR), real-time PCR, Sothern blot. The transgenic plants developed out of these cultivars are being evaluated for their efficacy against larvae as well adults of CPB. The transgenic lines are expected to inhibit expression of EcR protein gene, hindering their molting process, hence leading to increased potato yield. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=plant%20mediated%20RNAi" title="plant mediated RNAi">plant mediated RNAi</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20strategy" title=" molecular strategy"> molecular strategy</a>, <a href="https://publications.waset.org/abstracts/search?q=ecdysone%20receptor" title=" ecdysone receptor"> ecdysone receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=insect%20metamorphosis" title=" insect metamorphosis"> insect metamorphosis</a> </p> <a href="https://publications.waset.org/abstracts/93300/plant-mediated-rnai-approach-to-knock-down-ecdysone-receptor-gene-of-colorado-potato-beetle" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93300.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">170</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5657</span> The Role of Estradiol-17β and Type IV Collagen on the Regulation and Expression Level Of C-Erbb2 RNA and Protein in SKOV-3 Ovarian Cancer Cell Line </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Merry%20Meryam%20Martgrita">Merry Meryam Martgrita</a>, <a href="https://publications.waset.org/abstracts/search?q=Marselina%20Irasonia%20Tan"> Marselina Irasonia Tan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of several aggresive cancer is cancer that overexpress c-erbB2 receptor along with the expression of estrogen receptor. Components of extracellular matrix play an important role to increase cancer cells proliferation, migration and invasion. Both components can affect cancer development by regulating the signal transduction pathways in cancer cells. In recent research, SKOV-3 ovarian cancer cell line, that overexpress c-erbB2 receptor was cultured on type IV collagen and treated with estradiol-17β, to reveal the role of both components on RNA and protein level of c-erbB2 receptor. In this research we found a modulation phenomena of increasing and decreasing of c-erbB2 RNA level and a stabilisation phenomena of c-erbB2 protein expression due to estradiol-17β and type IV collagen. It seemed that estradiol-17β has an important role to increase c-erbB2 transcription and the stability of c-erbB2 protein expression. Type IV collagen has an opposite role. It blocked c-erbB2 transcription when it bound to integrin receptor in SKOV-3 cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=c-erbB2" title="c-erbB2">c-erbB2</a>, <a href="https://publications.waset.org/abstracts/search?q=estradiol-17%CE%B2" title=" estradiol-17β"> estradiol-17β</a>, <a href="https://publications.waset.org/abstracts/search?q=SKOV-3" title=" SKOV-3"> SKOV-3</a>, <a href="https://publications.waset.org/abstracts/search?q=type%20IV%20collagen" title=" type IV collagen"> type IV collagen</a> </p> <a href="https://publications.waset.org/abstracts/27964/the-role-of-estradiol-17v-and-type-iv-collagen-on-the-regulation-and-expression-level-of-c-erbb2-rna-and-protein-in-skov-3-ovarian-cancer-cell-line" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27964.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">284</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5656</span> Genome-Wide Significant SNPs Proximal to Nicotinic Receptor Genes Impact Cognition in Schizophrenia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Ahangari">Mohammad Ahangari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Schizophrenia is a psychiatric disorder with symptoms that include cognitive deficits and nicotine has been suggested to have an effect on cognition. In recent years, the advents of Genome-Wide Association Studies(GWAS) has evolved our understanding about the genetic causes of complex disorders such as schizophrenia and studying the role of genome-wide significant genes could potentially lead to the development of new therapeutic agents for treatment of cognitive deficits in schizophrenia. The current study identified six Single Nucleotide Polymorphisms (SNP) from schizophrenia and smoking GWAS that are located on or in close proximity to the nicotinic receptor gene cluster (CHRN) and studied their association with cognition in an Irish sample of 1297 cases and controls using linear regression analysis. Further on, the interaction between CHRN gene cluster and Dopamine receptor D2 gene (DRD2) during working memory was investigated. The effect of these polymorphisms on nicotinic and dopaminergic neurotransmission, which is disrupted in schizophrenia, have been characterized in terms of their effects on memory, attention, social cognition and IQ as measured by a neuropsychological test battery and significant effects in two polymorphisms were found across global IQ domain of the test battery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cognition" title="cognition">cognition</a>, <a href="https://publications.waset.org/abstracts/search?q=dopamine" title=" dopamine"> dopamine</a>, <a href="https://publications.waset.org/abstracts/search?q=GWAS" title=" GWAS"> GWAS</a>, <a href="https://publications.waset.org/abstracts/search?q=nicotine" title=" nicotine"> nicotine</a>, <a href="https://publications.waset.org/abstracts/search?q=schizophrenia" title=" schizophrenia"> schizophrenia</a>, <a href="https://publications.waset.org/abstracts/search?q=SNPs" title=" SNPs"> SNPs</a> </p> <a href="https://publications.waset.org/abstracts/43300/genome-wide-significant-snps-proximal-to-nicotinic-receptor-genes-impact-cognition-in-schizophrenia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43300.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">346</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5655</span> The Transcription Factor HNF4a: A Key Player in Haematological Disorders</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tareg%20Belali">Tareg Belali</a>, <a href="https://publications.waset.org/abstracts/search?q=Mosleh%20Abomughaid"> Mosleh Abomughaid</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhanad%20Alhujaily"> Muhanad Alhujaily</a> </p> <p class="card-text"><strong>Abstract:</strong></p> HNF4a is one of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, and apolipoproteins and blood coagulation. The transcriptional potency of HNF4a is well known due to its involvement in diabetes and other metabolic diseases. However, recently HNF4a has been discovered to be closely associated with several haematological disorders, mainly because of genetic mutations, drugs, and hepatic disorders. We review HNF4a structure and function and its role in haematological disorders. We discuss possible good therapies that are based on targeting HNF4a. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hepatocyte%20nuclear%20factor%204%20alpha" title="hepatocyte nuclear factor 4 alpha">hepatocyte nuclear factor 4 alpha</a>, <a href="https://publications.waset.org/abstracts/search?q=HNF4a%20nuclear%20receptor" title=" HNF4a nuclear receptor"> HNF4a nuclear receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=steroid%20hormone%20receptor%20family%20of%20transcription%20factors" title=" steroid hormone receptor family of transcription factors"> steroid hormone receptor family of transcription factors</a>, <a href="https://publications.waset.org/abstracts/search?q=hematological%20disorders" title=" hematological disorders"> hematological disorders</a> </p> <a href="https://publications.waset.org/abstracts/149357/the-transcription-factor-hnf4a-a-key-player-in-haematological-disorders" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149357.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">96</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5654</span> Development and Pre-clinical Evaluation of New ⁶⁴Cu-NOTA-Folate Conjugates for PET Imaging of Folate Receptor-Positive Tumors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Norah%20Al%20Hokbany">Norah Al Hokbany</a>, <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20Al%20Jammaz"> Ibrahim Al Jammaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Basem%20Al%20Otaibi"> Basem Al Otaibi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yousif%20Al%20Malki"> Yousif Al Malki</a>, <a href="https://publications.waset.org/abstracts/search?q=Subhani%20M.%20Okarvi"> Subhani M. Okarvi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The folate receptor is over-expressed in a wide variety of human tumors. Conjugates of folate have been shown to be selectively taken up by tumor cells via the folate receptor. In an attempt to develop new folate radiotracers with favorable biochemical properties for detecting folate receptor-positive cancers. Methods: we synthesized ⁶⁴Cu-NOTA- and ⁶⁴Cu-NOTAM-folate conjugates using a straightforward and simple one-step reaction. Radiochemical yields were greater than 95% (decay-corrected) with a total synthesis time of less than 20 min. Results: Radiochemical purities were always greater than 98% without high-performance liquid chromatography (HPLC) purification. These synthetic approaches hold considerable promise as a rapid and simple method for ⁶⁴Cu-folate conjugate preparation with high radiochemical yield in a short synthesis time. In vitro tests on the KB cell line showed that significant amounts of the radio conjugates were associated with cell fractions. Bio-distribution studies in nude mice bearing human KB xenografts demonstrated a significant tumor uptake and favorable bio-distribution profile for ⁶⁴Cu-NOTA- and ⁶⁴Cu-NOTAM-folate conjugate. The uptake in the tumors was blocked by the excess injection of folic acid, suggesting a receptor-mediated process. Conclusion: These results demonstrate that the ⁶⁴Cu-NOTAM-folate conjugate may be useful as a molecular probe for the detection and staging of folate receptor-positive cancers, such as ovarian cancer and their metastasis, as well as monitoring tumor response to treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=folate" title="folate">folate</a>, <a href="https://publications.waset.org/abstracts/search?q=receptor" title=" receptor"> receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20imaging" title=" tumor imaging"> tumor imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=%E2%81%B6%E2%81%B4Cu-NOTA-folate" title=" ⁶⁴Cu-NOTA-folate"> ⁶⁴Cu-NOTA-folate</a>, <a href="https://publications.waset.org/abstracts/search?q=PET" title=" PET"> PET</a> </p> <a href="https://publications.waset.org/abstracts/156848/development-and-pre-clinical-evaluation-of-new-64cu-nota-folate-conjugates-for-pet-imaging-of-folate-receptor-positive-tumors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156848.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">108</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5653</span> Identification of Target Receptor Compound 10,11-Dihidroerisodin as an Anti-Cancer Candidate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Srie%20Rezeki%20Nur%20Endah">Srie Rezeki Nur Endah</a>, <a href="https://publications.waset.org/abstracts/search?q=Richa%20Mardianingrum"> Richa Mardianingrum</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cancer is one of the most feared diseases and is considered the leading cause of death worldwide. Generally, cancer drugs are synthetic drugs with relatively more expensive prices and have harmful side effects, so many people turn to traditional medicine, for example by utilizing herbal medicine. Erythrina poeppigiana is one of the plants that can be used as a medicinal plant containing 10,11-dihidroerisodin compounds that are useful anticancer etnofarmakologi. The purpose of this study was to identify the target of 10,11 dihydroerisodin receptor compound as in silico anticancer candidate. The pure isolate was tested physicochemically by MS (Mass Spectrometry), UV-Vis (Ultraviolet – Visible), IR (Infra Red), 13C-NMR (Carbon-13 Nuclear Magnetic Resonance), 1H-NMR (Hydrogen-1 Nuclear Magnetic Resonance), to obtain the structure of 10,11-dihydroerisodin alkaloid compound then identified to target receptors in silico. From the results of the study, it was found that 10,11-dihydroerisodin compound can work on the Serine / threonine-protein kinase Chk1 receptor that serves as an anti-cancer candidate. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti-cancer" title="anti-cancer">anti-cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=Erythrina%20poeppigiana" title=" Erythrina poeppigiana"> Erythrina poeppigiana</a>, <a href="https://publications.waset.org/abstracts/search?q=target%20receptor" title=" target receptor"> target receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=10" title=" 10"> 10</a>, <a href="https://publications.waset.org/abstracts/search?q=11-%20dihidroerisodin" title="11- dihidroerisodin">11- dihidroerisodin</a> </p> <a href="https://publications.waset.org/abstracts/92293/identification-of-target-receptor-compound-1011-dihidroerisodin-as-an-anti-cancer-candidate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92293.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">246</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5652</span> Vegan Low Glycemic Index Diet in Appetite Reduction Among Polycystic Ovarian Syndrome (PCOS) Patients Carrying Melanocortin 4 Receptor (MC4R) Variants of (rs12970134), and (rs17782313): A Mini Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jumanah%20S.%20Alawfi">Jumanah S. Alawfi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polycystic ovary syndrome (PCOS) is a common endocrinopathy among females in their reproductive years. The incidence cases are nearly 1.55 million among females across the globe, with 0.43 million associated disability-adjusted life-years (DALYs). This syndrome is associated with intricate mechanisms typically characterized by insulin resistance (IR), infertility, overweight and/or obesity. Lifestyle interventions are often prescribed as an adjective treatment. Nonetheless, obesity is a complex disease that encompasses multiple dimensions, such as excessive energy intake and genetics. The melanocortin 4 receptor mutation (MC4R) is an important mediator in appetite. There is emerging evidence that suggests its role in the Body Mass Index (BMI) among PCOS subjects, which poses the question of obesity and/or overweight among the PCOS patients who carry the MC4R variants may be caused by overconsumption. Thereby, using other satiety techniques may be beneficial as a part of personalized nutrition. Therefore, the aim of the current mini-review is to discuss the effect of the vegan low glycemic diet on reducing appetite among PCOS patients. The review shows that there is a gap in the knowledge of the effect of the vegan diet on PCOS patients who carry MC4R variants which need further research. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polycystic%20ovarian%20syndrome%20%28PCOS%29" title="polycystic ovarian syndrome (PCOS)">polycystic ovarian syndrome (PCOS)</a>, <a href="https://publications.waset.org/abstracts/search?q=Appetite" title=" Appetite"> Appetite</a>, <a href="https://publications.waset.org/abstracts/search?q=Melanocortin%204%20Receptor%20Mutation%20%28MC4R%29." title=" Melanocortin 4 Receptor Mutation (MC4R)."> Melanocortin 4 Receptor Mutation (MC4R).</a>, <a href="https://publications.waset.org/abstracts/search?q=Obesity" title=" Obesity"> Obesity</a> </p> <a href="https://publications.waset.org/abstracts/169095/vegan-low-glycemic-index-diet-in-appetite-reduction-among-polycystic-ovarian-syndrome-pcos-patients-carrying-melanocortin-4-receptor-mc4r-variants-of-rs12970134-and-rs17782313-a-mini-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169095.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5651</span> Microglia Activity and Induction of Mechanical Allodynia after Mincle Receptor Ligand Injection in Rat Spinal Cord</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jihoon%20Yang">Jihoon Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeong%20II%20Choi"> Jeong II Choi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mincle is expressed in macrophages and is members of immunoreceptors induced after exposure to various stimuli and stresses. Mincle receptor activation promotes the production of these substances by increasing the transcription of inflammatory cytokines and chemokines. Cytokines, which play an important role in the initiation and maintenance of such inflammatory pain diseases, have a significant effect on sensory neurons in addition to their enhancement and inhibitory effects on immune and inflammatory cells as mediators of cell interaction. Glial cells in the central nervous system play a critical role in development and maintenance of chronic pain states. Microglia are tissue-resident macrophages in the central nervous system, and belong to a group of mononuclear phagocytes. In the central nervous system, mincle receptor is present in neurons and glial cells of the brain.This study was performed to identify the Mincle receptor in the spinal cord and to investigate the effect of Mincle receptor activation on nociception and the changes of microglia. Materials and Methods: C-type lectins(Mincle) was identified in spinal cord of Male Sprague–Dawley rats. Then, mincle receptor ligand (TDB), via an intrathecal catheter. Mechanical allodynia was measured using von Frey test to evaluate the effect of intrathecal injection of TDB. Result: The present investigation shows that the intrathecal administration of TDB in the rat produces a reliable and quantifiable mechanical hyperalgesia. In addition, The mechanical hyperalgesia after TDB injection gradually developed over time and remained until 10 days. Mincle receptor is identified in the spinal cord, mainly expressed in neuronal cells, but not in microglia or astrocyte. These results suggest that activation of mincle receptor pathway in neurons plays an important role in inducing activation of microglia and inducing mechanical allodynia. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mincle" title="mincle">mincle</a>, <a href="https://publications.waset.org/abstracts/search?q=spinal%20cord" title=" spinal cord"> spinal cord</a>, <a href="https://publications.waset.org/abstracts/search?q=pain" title=" pain"> pain</a>, <a href="https://publications.waset.org/abstracts/search?q=microglia" title=" microglia"> microglia</a> </p> <a href="https://publications.waset.org/abstracts/79571/microglia-activity-and-induction-of-mechanical-allodynia-after-mincle-receptor-ligand-injection-in-rat-spinal-cord" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79571.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5650</span> Non-Signaling Chemokine Receptor CCRL1 and Its Active Counterpart CCR7 in Prostate Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yiding%20Qu">Yiding Qu</a>, <a href="https://publications.waset.org/abstracts/search?q=Svetlana%20V.%20Komarova"> Svetlana V. Komarova</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chemokines acting through their cognate chemokine receptors guide the directional migration of the cell along the chemokine gradient. Several chemokine receptors were recently identified as non-signaling (decoy), based on their ability to bind the chemokine but produce no measurable signal in the cell. The function of these decoy receptors is not well understood. We examined the expression of a decoy receptor CCRL1 and a signaling receptor that binds to the same ligands, CCR7, in prostate cancer using publically available microarray data (www.oncomine.org). The expression of both CCRL1 and CCR7 increased in an approximately half of prostate carcinoma samples and the majority of metastatic cancer samples compared to normal prostate. Moreover, the expression of CCRL1 positively correlated with the expression of CCR7. These data suggest that CCR7 and CCRL1 can be used as clinical markers for the early detection of transformation from carcinoma to metastatic cancer. In addition, these data support our hypothesis that the non-signaling chemokine receptors actively stimulate cell migration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bioinformatics" title="bioinformatics">bioinformatics</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20migration" title=" cell migration"> cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=decoy%20receptor" title=" decoy receptor"> decoy receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=meta-analysis" title=" meta-analysis"> meta-analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=prostate%20cancer" title=" prostate cancer"> prostate cancer</a> </p> <a href="https://publications.waset.org/abstracts/23226/non-signaling-chemokine-receptor-ccrl1-and-its-active-counterpart-ccr7-in-prostate-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23226.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5649</span> A Platform to Screen Targeting Molecules of Ligand-EGFR Interactions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wei-Ting%20Kuo">Wei-Ting Kuo</a>, <a href="https://publications.waset.org/abstracts/search?q=Feng-Huei%20Lin"> Feng-Huei Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epidermal growth factor receptor (EGFR) is often constitutively stimulated in cancer owing to the binding of ligands such as epidermal growth factor (EGF), so it is necessary to investigate the interaction between EGFR and its targeting biomolecules which were over ligands binding. This study would focus on the binding affinity and adhesion force of two targeting products anti-EGFR monoclonal antibody (mAb) and peptide A to EGFR comparing with EGF. Surface plasmon resonance (SPR) was used to obtain the equilibrium dissociation constant to evaluate the binding affinity. Atomic force microscopy (AFM) was performed to detect adhesion force. The result showed that binding affinity of mAb to EGFR was higher than that of EGF to EGFR, and peptide A to EGFR was lowest. The adhesion force between EGFR and mAb that was higher than EGF and peptide A to EGFR was lowest. From the studies, we could conclude that mAb had better adhesion force and binding affinity to EGFR than that of EGF and peptide A. SPR and AFM could confirm the interaction between receptor and targeting ligand easily and carefully. It provide a platform to screen ligands for receptor targeting and drug delivery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adhesion%20force" title="adhesion force">adhesion force</a>, <a href="https://publications.waset.org/abstracts/search?q=binding%20affinity" title=" binding affinity"> binding affinity</a>, <a href="https://publications.waset.org/abstracts/search?q=epidermal%20growth%20factor%20receptor" title=" epidermal growth factor receptor"> epidermal growth factor receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=target%20molecule" title=" target molecule"> target molecule</a> </p> <a href="https://publications.waset.org/abstracts/27370/a-platform-to-screen-targeting-molecules-of-ligand-egfr-interactions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27370.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">433</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=6">6</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=7">7</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=8">8</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=9">9</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=10">10</a></li> <li class="page-item disabled"><span class="page-link">...</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=189">189</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=190">190</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=GABAA%2Fbezodiazepine%20receptor%20complex&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>