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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F50639869%2FAqueous_extract_of_ginger_shows_antiproliferative_activity_through_disruption_of_microtubule_network_of_cancer_cells%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":68546215,"identifier":"Attachment_68546215","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":50639869,"created_at":"2021-08-03T05:32:29.412-07:00","from_world_paper_id":171507982,"updated_at":"2024-11-22T19:09:29.349-08:00","_data":{"publisher":"Elsevier BV","grobid_abstract":"Ginger has a long history of use as traditional medicine for varied human disease. Our present study has shown that the aqueous extract of ginger (GAE) interacts directly with cellular microtubules and disrupts its structure and induces apoptosis of cancer cells as well. The IC 50 values of GAE, as determined from cell viability experiment on human non-small lung epithelium cancer (A549) cells and human cervical epithelial carcinoma (HeLa), were 239.4 + 7.4 and 253.4 + 8.9 lg/ml, respectively. It has been found that the apoptosis of A549 cells by GAE is mediated by up regulation of tumor suppressor gene p53 and alteration of the normal Bax/Bcl-2 ratio followed by down regulation of cellular pro-caspase3. The morphological change of cells upon GAE treatment has also been demonstrated. Both the structural and functional properties of tubulin and microtubule were lost, as confirmed by both ex vivo and in vitro experiments. The major component of GAE is poly-phenols (around 2.5%), which consist of $80% flavones and flavonols. Poly-phenolic compounds are well known to have anti-mitotic properties, and may be further screened for the development of a potential anti-cancer agent.","publication_date":"2010,,","publication_name":"Food and Chemical Toxicology","grobid_abstract_attachment_id":"68546215"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [120659023]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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R Lakho</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41300572" href="https://independent.academia.edu/DileepRohra">Dileep Rohra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">journal-mhr.com</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"TARGETING APOPTOSIS WITH COMPOUNDS FROM COMMONLY-USED MEDICINAL PLANTS: APossible AID IN THE FIGHT AGAINST CANCER?","attachmentId":41212797,"attachmentType":"pdf","work_url":"https://www.academia.edu/20071477/TARGETING_APOPTOSIS_WITH_COMPOUNDS_FROM_COMMONLY_USED_MEDICINAL_PLANTS_APossible_AID_IN_THE_FIGHT_AGAINST_CANCER","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20071477/TARGETING_APOPTOSIS_WITH_COMPOUNDS_FROM_COMMONLY_USED_MEDICINAL_PLANTS_APossible_AID_IN_THE_FIGHT_AGAINST_CANCER"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="46497810" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway">NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29829624" href="https://mohp.academia.edu/AlaaeldinHamza">Alaaeldin A Hamza</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Elsevier Masson SAS, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Ginger has been proposed as quite a promising candidate for cancer prevention. The purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this study investigated the possible mechanisms of a standardized extract drawn from the rhizomes of ginger against diethylnitrosamine (DEN)-induced liver cancer in Wistar rats. The chemo-preventive effects of ginger at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg per day were determined using a liver cancer model which was induced by DEN (Ali et al., 2008) and 2-acetylaminofluor-ene (2-AAF) in rats. Ginger attenuated carcinogenic changes after 22 weeks of cancer induction by decreasing the quantity and occurrences of hepatic dyschromatic nodules and positive focal areas as well as decreasing the amount of placental glutathione S-transferase (GST) in the livers of DEN/2-AAF-treated rats. Moreover, in rats, ginger counteracts DEN-influenced oxidative stress and decreases myeloperoxidase, malondialdehyde and protein carbonyl concentrations in the liver. This was determined by observing the restoration of superoxide dis-mutase, catalase, GST and glutathione. Immunohistochemical bleaching in rat livers showed that ginger prevented the increase in cell-positive numbers for Ki-67, cyclooxygenase-2 and nuclear factor kappa B p65. Ginger also inhibited the number of positive cells in DEN/2-AAF-treated rats for TUNEL, M30 and caspase-3 liver tissues. This research shows that ginger has an important chemo-preventative impact on liver cancer by inhibiting the growth of cells and inducing apoptosis. By reducing oxidative and inflammatory damage, ginger protects rat liver against cancer.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NC-ND license Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway","attachmentId":66228604,"attachmentType":"pdf","work_url":"https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/46497810/NC_ND_license_Standardized_extract_of_ginger_ameliorates_liver_cancer_by_reducing_proliferation_and_inducing_apoptosis_through_inhibition_oxidative_stress_inflammation_pathway"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="111389490" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111389490/Anticancer_Effects_of_Herbal_Medicine_Compounds_and_Novel_Formulations_a_Literature_Review">Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="142086591" href="https://independent.academia.edu/The_Queen">Manal K Abdulridha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Gastrointestinal Cancer, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review","attachmentId":108944301,"attachmentType":"pdf","work_url":"https://www.academia.edu/111389490/Anticancer_Effects_of_Herbal_Medicine_Compounds_and_Novel_Formulations_a_Literature_Review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/111389490/Anticancer_Effects_of_Herbal_Medicine_Compounds_and_Novel_Formulations_a_Literature_Review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="4085611" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis">Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4926261" href="https://independent.academia.edu/MadhulikaSingh1">Madhulika Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Chemotherapy and Pharmacology, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Purpose To unravel the molecular mechanisms underlying the chemopreventive potential of [6]-gingerol, a pungent ingredient of ginger rhizome (Zingiber officinale Roscoe, Zingiberaceae), against benzo[a]pyrene (B[a]P)-induced mouse skin tumorigenesis. Methods Topical treatment of [6]-gingerol (2.5 μM/animal) was given to the animals 30 min prior and post to B[a]P (5 μg/animal) for 32 weeks. At the end of the study period, the skin tumors/tissues were dissected out and examined histopathologically. Flow cytometry was employed for cell cycle analysis. Further immunohistochemical localization of p53 and regulation of related apoptogenic proteins were determined by Western blotting. Results Chemopreventive properties of [6]-gingerol were reflected by delay in onset of tumorigenesis, reduced cumulative number of tumors, and reduction in tumor volume. Cell cycle analysis revealed that the appearance of sub-G1 peak was significantly elevated in [6]-gingerol treated animals with post treatment showing higher efficacy in preventing tumorigenesis induced by B[a]P. Moreover, elevated apoptotic propensity was observed in tumor tissues than the corresponding non-tumor tissues. Western blot analysis also showed the same pattern of chemoprevention with [6]-gingerol treatment increasing the B[a]P suppressed p53 levels, also evident by immunohistochemistry, and Bax while decreasing the expression of Bcl-2 and Survivin. Further, [6]-gingerol treatment resulted in release of Cytochrome c, Caspases activation, increase in apoptotic protease-activating factor-1 (Apaf-1) as mechanism of apoptosis induction. Conclusions On the basis of the results we conclude that [6]-gingerol possesses apoptotic potential in mouse skin tumors as mechanism of chemoprevention hence deserves further investigation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis","attachmentId":50042371,"attachmentType":"pdf","work_url":"https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4085611/Induction_of_apoptosis_by_6_gingerol_associated_with_the_modulation_of_p53_and_involvement_of_mitochondrial_signaling_pathway_in_B_a_P_induced_mouse_skin_tumorigenesis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":68546215,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":68546215,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_68546215" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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