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Search results for: homology modelling

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</div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: homology modelling</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1871</span> Local Homology Modules</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatemeh%20Mohammadi%20Aghjeh%20Mashhad">Fatemeh Mohammadi Aghjeh Mashhad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, we give several ways for computing generalized local homology modules by using Gorenstein flat resolutions. Also, we find some bounds for vanishing of generalized local homology modules. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=a-adic%20completion%20functor" title="a-adic completion functor">a-adic completion functor</a>, <a href="https://publications.waset.org/abstracts/search?q=generalized%20local%20homology%20modules" title=" generalized local homology modules"> generalized local homology modules</a>, <a href="https://publications.waset.org/abstracts/search?q=Gorenstein%20flat%20modules" title=" Gorenstein flat modules"> Gorenstein flat modules</a> </p> <a href="https://publications.waset.org/abstracts/23188/local-homology-modules" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23188.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">419</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1870</span> Explicit Chain Homotopic Function to Compute Hochschild Homology of the Polynomial Algebra</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zuhier%20Altawallbeh">Zuhier Altawallbeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, an explicit homotopic function is constructed to compute the Hochschild homology of a finite dimensional free k-module V. Because the polynomial algebra is of course fundamental in the computation of the Hochschild homology HH and the cyclic homology CH of commutative algebras, we concentrate our work to compute HH of the polynomial algebra.by providing certain homotopic function. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hochschild%20homology" title="hochschild homology">hochschild homology</a>, <a href="https://publications.waset.org/abstracts/search?q=homotopic%20function" title=" homotopic function"> homotopic function</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20and%20projective%20modules" title=" free and projective modules"> free and projective modules</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20resolution" title=" free resolution"> free resolution</a>, <a href="https://publications.waset.org/abstracts/search?q=exterior%20algebra" title=" exterior algebra"> exterior algebra</a>, <a href="https://publications.waset.org/abstracts/search?q=symmetric%20algebra" title=" symmetric algebra"> symmetric algebra</a> </p> <a href="https://publications.waset.org/abstracts/20251/explicit-chain-homotopic-function-to-compute-hochschild-homology-of-the-polynomial-algebra" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20251.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1869</span> Persistent Homology of Convection Cycles in Network Flows</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Minh%20Quang%20Le">Minh Quang Le</a>, <a href="https://publications.waset.org/abstracts/search?q=Dane%20Taylor"> Dane Taylor</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Convection is a well-studied topic in fluid dynamics, yet it is less understood in the context of networks flows. Here, we incorporate techniques from topological data analysis (namely, persistent homology) to automate the detection and characterization of convective/cyclic/chiral flows over networks, particularly those that arise for irreversible Markov chains (MCs). As two applications, we study convection cycles arising under the PageRank algorithm, and we investigate chiral edges flows for a stochastic model of a bi-monomer's configuration dynamics. Our experiments highlight how system parameters---e.g., the teleportation rate for PageRank and the transition rates of external and internal state changes for a monomer---can act as homology regularizers of convection, which we summarize with persistence barcodes and homological bifurcation diagrams. Our approach establishes a new connection between the study of convection cycles and homology, the branch of mathematics that formally studies cycles, which has diverse potential applications throughout the sciences and engineering. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=homology" title="homology">homology</a>, <a href="https://publications.waset.org/abstracts/search?q=persistent%20homolgy" title=" persistent homolgy"> persistent homolgy</a>, <a href="https://publications.waset.org/abstracts/search?q=markov%20chains" title=" markov chains"> markov chains</a>, <a href="https://publications.waset.org/abstracts/search?q=convection%20cycles" title=" convection cycles"> convection cycles</a>, <a href="https://publications.waset.org/abstracts/search?q=filtration" title=" filtration"> filtration</a> </p> <a href="https://publications.waset.org/abstracts/146580/persistent-homology-of-convection-cycles-in-network-flows" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146580.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1868</span> Protein Remote Homology Detection and Fold Recognition by Combining Profiles with Kernel Methods</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bin%20Liu">Bin Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Protein remote homology detection and fold recognition are two most important tasks in protein sequence analysis, which is critical for protein structure and function studies. In this study, we combined the profile-based features with various string kernels, and constructed several computational predictors for protein remote homology detection and fold recognition. Experimental results on two widely used benchmark datasets showed that these methods outperformed the competing methods, indicating that these predictors are useful computational tools for protein sequence analysis. By analyzing the discriminative features of the training models, some interesting patterns were discovered, reflecting the characteristics of protein superfamilies and folds, which are important for the researchers who are interested in finding the patterns of protein folds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=protein%20remote%20homology%20detection" title="protein remote homology detection">protein remote homology detection</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20fold%20recognition" title=" protein fold recognition"> protein fold recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=profile-based%20features" title=" profile-based features"> profile-based features</a>, <a href="https://publications.waset.org/abstracts/search?q=Support%20Vector%20Machines%20%28SVMs%29" title=" Support Vector Machines (SVMs)"> Support Vector Machines (SVMs)</a> </p> <a href="https://publications.waset.org/abstracts/104054/protein-remote-homology-detection-and-fold-recognition-by-combining-profiles-with-kernel-methods" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/104054.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">161</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1867</span> Homology Modelling of Beta Defensin 3 of Bos taurus and Its Docking Studies with Molecules Responsible for Formation of Biofilm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ravinder%20Singh">Ravinder Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ankita%20Gurao"> Ankita Gurao</a>, <a href="https://publications.waset.org/abstracts/search?q=Saroj%20Bandhan"> Saroj Bandhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sudhir%20Kumar%20Kashyap"> Sudhir Kumar Kashyap </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Bos taurus Beta defensin 3 is a defensin peptide secreted by neutrophils and epithelial that exhibits anti-microbial activity. It is one of the crucial components forming an innate defense against intra mammary infections in livestock. The beta defensin 3 by virtue of its anti-microbial activity inhibits major mastitis pathogens including Staphylococcus aureus and Pseudomonas aeruginosa etc, which are also responsible for biofilm formation leading to antibiotic resistance phenomenon. Therefore, the defensin may prove as a non-conventional option to treat mastitis. In this study, computational analysis has been performed including sequence comparison among species and homology modeling of Bos taurus beta defensin 3 protein. The assessments of protein structure were done using the protein structure and model assessment tools integrated in Swiss Model server, which employs various local and global quality evaluation parameters. Further, molecular docking was also carried out between the defensin peptide and the components of biofilm to gain insight into various interactions and structural differences crucial for functionality of this protein. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20defensin%203" title="beta defensin 3">beta defensin 3</a>, <a href="https://publications.waset.org/abstracts/search?q=bos%20taurus" title=" bos taurus"> bos taurus</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modeling" title=" homology modeling"> homology modeling</a> </p> <a href="https://publications.waset.org/abstracts/64346/homology-modelling-of-beta-defensin-3-of-bos-taurus-and-its-docking-studies-with-molecules-responsible-for-formation-of-biofilm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">291</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1866</span> Interaction of Phytochemicals Present in Green Tea, Honey and Cinnamon to Human Melanocortin 4 Receptor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chinmayee%20Choudhury">Chinmayee Choudhury</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Human Melanocortin 4 Receptor (HMC4R) is one of the most potential drug targets for the treatment of obesity which controls the appetite. A deletion of the residues 88-92 in HMC4R is sometimes the cause of severe obesity in the humans. In this study, two homology models are constructed for the normal as well as mutated HMC4Rs and some phytochemicals present in Green Tea, Honey and Cinnamon have been docked to them to study their differential binding to the normal and mutated HMC4R as compared to the natural agonist α- MSH. Two homology models have been constructed for the normal as well as mutated HMC4Rs using the Modeller9v7. Some of the phytochemicals present in Green Tea, Honey, and Cinnamon, which have appetite suppressant activities are constructed, minimized and docked to these normal and mutated HMC4R models using ArgusLab 4.0.1. The mode of binding of the phytochemicals with the Normal and Mutated HMC4Rs have been compared. Further, the mode of binding of these phytochemicals with that of the natural agonist α- Melanocyte Stimulating Hormone(α-MSH) to both normal and mutated HMC4Rs have also been studied. It is observed that the phytochemicals Kaempherol, Epigallocatechin-3-gallate (EGCG) present in Green Tea and Honey, Isorhamnetin, Chlorogenic acid, Chrysin, Galangin, Pinocambrin present in Honey, Cinnamaldehyde, Cinnamyl acetate and Cinnamyl alcohol present in Cinnamon have capacity to form more stable complexes with the Mutated HMC4R as compared to α- MSH. So they may be potential agonists of HMC4R to suppress the appetite. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HMC4R" title="HMC4R">HMC4R</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-MSH" title=" α-MSH"> α-MSH</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=photochemical" title=" photochemical"> photochemical</a>, <a href="https://publications.waset.org/abstracts/search?q=appetite%20suppressant" title=" appetite suppressant"> appetite suppressant</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modelling" title=" homology modelling"> homology modelling</a> </p> <a href="https://publications.waset.org/abstracts/78541/interaction-of-phytochemicals-present-in-green-tea-honey-and-cinnamon-to-human-melanocortin-4-receptor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78541.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">195</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1865</span> Identification of Clinical Characteristics from Persistent Homology Applied to Tumor Imaging </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eashwar%20V.%20Somasundaram">Eashwar V. Somasundaram</a>, <a href="https://publications.waset.org/abstracts/search?q=Raoul%20R.%20Wadhwa"> Raoul R. Wadhwa</a>, <a href="https://publications.waset.org/abstracts/search?q=Jacob%20G.%20Scott"> Jacob G. Scott</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of radiomics in measuring geometric properties of tumor images such as size, surface area, and volume has been invaluable in assessing cancer diagnosis, treatment, and prognosis. In addition to analyzing geometric properties, radiomics would benefit from measuring topological properties using persistent homology. Intuitively, features uncovered by persistent homology may correlate to tumor structural features. One example is necrotic cavities (corresponding to 2D topological features), which are markers of very aggressive tumors. We develop a data pipeline in R that clusters tumors images based on persistent homology is used to identify meaningful clinical distinctions between tumors and possibly new relationships not captured by established clinical categorizations. A preliminary analysis was performed on 16 Magnetic Resonance Imaging (MRI) breast tissue segments downloaded from the 'Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis' (I-SPY TRIAL or ISPY1) collection in The Cancer Imaging Archive. Each segment represents a patient’s breast tumor prior to treatment. The ISPY1 dataset also provided the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status data. A persistent homology matrix up to 2-dimensional features was calculated for each of the MRI segmentation. Wasserstein distances were then calculated between all pairwise tumor image persistent homology matrices to create a distance matrix for each feature dimension. Since Wasserstein distances were calculated for 0, 1, and 2-dimensional features, three hierarchal clusters were constructed. The adjusted Rand Index was used to see how well the clusters corresponded to the ER/PR/HER2 status of the tumors. Triple-negative cancers (negative status for all three receptors) significantly clustered together in the 2-dimensional features dendrogram (Adjusted Rand Index of .35, p = .031). It is known that having a triple-negative breast tumor is associated with aggressive tumor growth and poor prognosis when compared to non-triple negative breast tumors. The aggressive tumor growth associated with triple-negative tumors may have a unique structure in an MRI segmentation, which persistent homology is able to identify. This preliminary analysis shows promising results in the use of persistent homology on tumor imaging to assess the severity of breast tumors. The next step is to apply this pipeline to other tumor segment images from The Cancer Imaging Archive at different sites such as the lung, kidney, and brain. In addition, whether other clinical parameters, such as overall survival, tumor stage, and tumor genotype data are captured well in persistent homology clusters will be assessed. If analyzing tumor MRI segments using persistent homology consistently identifies clinical relationships, this could enable clinicians to use persistent homology data as a noninvasive way to inform clinical decision making in oncology. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20biology" title="cancer biology">cancer biology</a>, <a href="https://publications.waset.org/abstracts/search?q=oncology" title=" oncology"> oncology</a>, <a href="https://publications.waset.org/abstracts/search?q=persistent%20homology" title=" persistent homology"> persistent homology</a>, <a href="https://publications.waset.org/abstracts/search?q=radiomics" title=" radiomics"> radiomics</a>, <a href="https://publications.waset.org/abstracts/search?q=topological%20data%20analysis" title=" topological data analysis"> topological data analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20imaging" title=" tumor imaging"> tumor imaging</a> </p> <a href="https://publications.waset.org/abstracts/125882/identification-of-clinical-characteristics-from-persistent-homology-applied-to-tumor-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/125882.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1864</span> Protein Remote Homology Detection by Using Profile-Based Matrix Transformation Approaches</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bin%20Liu">Bin Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> As one of the most important tasks in protein sequence analysis, protein remote homology detection has been studied for decades. Currently, the profile-based methods show state-of-the-art performance. Position-Specific Frequency Matrix (PSFM) is widely used profile. However, there exists noise information in the profiles introduced by the amino acids with low frequencies. In this study, we propose a method to remove the noise information in the PSFM by removing the amino acids with low frequencies called Top frequency profile (TFP). Three new matrix transformation methods, including Autocross covariance (ACC) transformation, Tri-gram, and K-separated bigram (KSB), are performed on these profiles to convert them into fixed length feature vectors. Combined with Support Vector Machines (SVMs), the predictors are constructed. Evaluated on two benchmark datasets, and experimental results show that these proposed methods outperform other state-of-the-art predictors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=protein%20remote%20homology%20detection" title="protein remote homology detection">protein remote homology detection</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20fold%20recognition" title=" protein fold recognition"> protein fold recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=top%20frequency%20profile" title=" top frequency profile"> top frequency profile</a>, <a href="https://publications.waset.org/abstracts/search?q=support%20vector%20machines" title=" support vector machines"> support vector machines</a> </p> <a href="https://publications.waset.org/abstracts/103989/protein-remote-homology-detection-by-using-profile-based-matrix-transformation-approaches" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/103989.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">125</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1863</span> Mechanism of Melanin Inhibition of Morello Flavone- 7″- Sulphate and Sargaol extracts from Garcinia livingstonei (Clusiaceae): Homology Modelling, Molecular Docking, and Molecular Dynamics Simulations </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ncoza%20Dlova">Ncoza Dlova</a>, <a href="https://publications.waset.org/abstracts/search?q=Tivani%20Mashamba-Thompson"> Tivani Mashamba-Thompson</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Garcinia livingstonei (Clusiaceae) extracts, morelloflavone- 7″- sulphate and sargaol were shown to be effective against hyper-pigmentation through inhibition of tyrosinase enzyme, in vitro . The aim of this study is to elucidate the structural mechanism through which morelloflavone- 7″- sulphate and sargaol binds human tyrosinase. Implementing a homology model to construct a tyrosinase model using the crystal structure of a functional unit from Octopus hemocyanin (PDB: 1JS8) as a reference template enabled us to create a human tyrosinase model. Molecular dynamics and binding free energy calculations were optimized to enable molecular dynamics simulation of the copper dependent inhibitors. Results show the importance of the hydrogen bond formation morelloflavone- 7″- sulphate and sargaol between compound and active site residues. Both complexes demonstrated the metallic coordination between compound and arginine residue as well as copper ions within the active site. The comprehensive molecular insight gained from this study should be vital in understanding the binding mechanism morelloflavone- 7″- sulphate and sargaol. Moreover, these results will assist in the design of novel of metal ion dependent enzyme inhibitors as potential anti-hyper-pigmentation disorder therapies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hyper-pigmentation%20disorders" title="hyper-pigmentation disorders">hyper-pigmentation disorders</a>, <a href="https://publications.waset.org/abstracts/search?q=dyschromia%20African%20skin" title=" dyschromia African skin"> dyschromia African skin</a>, <a href="https://publications.waset.org/abstracts/search?q=morelloflavone-%207%E2%80%B3-%20sulphate" title=" morelloflavone- 7″- sulphate"> morelloflavone- 7″- sulphate</a>, <a href="https://publications.waset.org/abstracts/search?q=sagoal" title=" sagoal"> sagoal</a> </p> <a href="https://publications.waset.org/abstracts/14126/mechanism-of-melanin-inhibition-of-morello-flavone-7-sulphate-and-sargaol-extracts-from-garcinia-livingstonei-clusiaceae-homology-modelling-molecular-docking-and-molecular-dynamics-simulations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14126.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">406</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1862</span> On the Homology Modeling, Structural Function Relationship and Binding Site Prediction of Human Alsin Protein</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Ruchi">Y. Ruchi</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Prerna"> A. Prerna</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Deepshikha"> S. Deepshikha </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Amyotrophic lateral sclerosis (ALS), also known as “Lou Gehrig’s disease”. It is a neurodegenerative disease associated with degeneration of motor neurons in the cerebral cortex, brain stem, and spinal cord characterized by distal muscle weakness, atrophy, normal sensation, pyramidal signs and progressive muscular paralysis reflecting. ALS2 is a juvenile autosomal recessive disorder, slowly progressive, that maps to chromosome 2q33 and is associated with mutations in the alsin gene, a putative GTPase regulator. In this paper we have done homology modeling of alsin2 protein using multiple templates (3KCI_A, 4LIM_A, 402W_A, 4D9S_A, and 4DNV_A) designed using the Prime program in Schrödinger software. Further modeled structure is used to identify effective binding sites on the basis of structural and physical properties using sitemap program in Schrödinger software, structural and function analysis is done by using Prosite and ExPASy server that gives insight into conserved domains and motifs that can be used for protein classification. This paper summarizes the structural, functional and binding site property of alsin2 protein. These binding sites can be potential drug target sites and can be used for docking studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ALS" title="ALS">ALS</a>, <a href="https://publications.waset.org/abstracts/search?q=binding%20site" title=" binding site"> binding site</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modeling" title=" homology modeling"> homology modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=neuronal%20degeneration" title=" neuronal degeneration"> neuronal degeneration</a> </p> <a href="https://publications.waset.org/abstracts/20360/on-the-homology-modeling-structural-function-relationship-and-binding-site-prediction-of-human-alsin-protein" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20360.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1861</span> The World View of Tere Liye in Negeri Para Bedebah an Analysis of Genetic Structuralism Lucien Goldmann</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Fadli%20Muslimin">Muhammad Fadli Muslimin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Negeri Para Bedebah is known as one of the works of Tere Liye, an Indonesia author. In the literary works, the fiction as always tries to reflect the reality of the society where the author or the social groups lived in. The essential or nature of society is generally a reality while literary work is fiction and both of them are social fact. Negeri Para Bedebah is a novel fiction which is a social fact and which holds an important role in reality. It is more likely as the representation of social, economy and politic aspects in Indonesia. The purpose of this study is to reveal the world view of Tere Liye throughout novel Negeri Para Bedebah. By analyzing the object using genetic structuralism Lucien Goldmann which chiefly focuses on world view, it is stated that the literary work is an structure and it has homology with the structure in society. The structure of literary work is not chiefly homolog to the structure of society but homolog to the world view which is growing and developing inside the society. The methodological research used in this paper is a dialectic method which focuses on the starting and ending points lied in the literary text by paying attention to the coherent meanings. The result of this study is that Tere Liye shows us his world view about the structure of the society where he is living in, but one is an imaginative form of the world and the homology to the reality itself. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=homology" title="homology">homology</a>, <a href="https://publications.waset.org/abstracts/search?q=literary%20work" title=" literary work"> literary work</a>, <a href="https://publications.waset.org/abstracts/search?q=society" title=" society"> society</a>, <a href="https://publications.waset.org/abstracts/search?q=structure" title=" structure"> structure</a>, <a href="https://publications.waset.org/abstracts/search?q=world%20view" title=" world view"> world view</a> </p> <a href="https://publications.waset.org/abstracts/78926/the-world-view-of-tere-liye-in-negeri-para-bedebah-an-analysis-of-genetic-structuralism-lucien-goldmann" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">511</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1860</span> A Similarity/Dissimilarity Measure to Biological Sequence Alignment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20A.%20Khan">Muhammad A. Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Waseem%20Shahzad"> Waseem Shahzad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Analysis of protein sequences is carried out for the purpose to discover their structural and ancestry relationship. Sequence similarity determines similar protein structures, similar function, and homology detection. Biological sequences composed of amino acid residues or nucleotides provide significant information through sequence alignment. In this paper, we present a new similarity/dissimilarity measure to sequence alignment based on the primary structure of a protein. The approach finds the distance between the two given sequences using the novel sequence alignment algorithm and a mathematical model. The algorithm runs at a time complexity of O(n²). A distance matrix is generated to construct a phylogenetic tree of different species. The new similarity/dissimilarity measure outperforms other existing methods. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alignment" title="alignment">alignment</a>, <a href="https://publications.waset.org/abstracts/search?q=distance" title=" distance"> distance</a>, <a href="https://publications.waset.org/abstracts/search?q=homology" title=" homology"> homology</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20model" title=" mathematical model"> mathematical model</a>, <a href="https://publications.waset.org/abstracts/search?q=phylogenetic%20tree" title=" phylogenetic tree"> phylogenetic tree</a> </p> <a href="https://publications.waset.org/abstracts/95183/a-similaritydissimilarity-measure-to-biological-sequence-alignment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/95183.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">178</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1859</span> Modelling Railway Noise Over Large Areas, Assisted by GIS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Conrad%20Weber">Conrad Weber</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The modelling of railway noise over large projects areas can be very time consuming in terms of preparing the noise models and calculation time. An open-source GIS program has been utilised to assist with the modelling of operational noise levels for 675km of railway corridor. A range of GIS algorithms were utilised to break up the noise model area into manageable calculation sizes. GIS was utilised to prepare and filter a range of noise modelling inputs, including building files, land uses and ground terrain. A spreadsheet was utilised to manage the accuracy of key input parameters, including train speeds, train types, curve corrections, bridge corrections and engine notch settings. GIS was utilised to present the final noise modelling results. This paper explains the noise modelling process and how the spreadsheet and GIS were utilised to accurately model this massive project efficiently. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=noise" title="noise">noise</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling" title=" modeling"> modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=GIS" title=" GIS"> GIS</a>, <a href="https://publications.waset.org/abstracts/search?q=rail" title=" rail"> rail</a> </p> <a href="https://publications.waset.org/abstracts/154298/modelling-railway-noise-over-large-areas-assisted-by-gis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154298.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1858</span> Effect of Low Temperature on Structure and RNA Binding of E.coli CspA: A Molecular Dynamics Based Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amit%20Chaudhary">Amit Chaudhary</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20S.%20Yadav"> B. S. Yadav</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20K.%20Maurya"> P. K. Maurya</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M."> A. M.</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Srivastava"> S. Srivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Singh"> S. Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Mani"> A. Mani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cold shock protein A (CspA) is major cold inducible protein present in Escherichia coli. The protein is involved in stabilizing secondary structure of RNA by working as chaperone during cold temperature. Two RNA binding motifs play key role in the stabilizing activity. This study aimed to investigate implications of low temperature on structure and RNA binding activity of E. coli CspA. Molecular dynamics simulations were performed to compare the stability of the protein at 37°C and 10 °C. The protein was mutated at RNA binding motifs and docked with RNA to assess the stability of both complexes. Results suggest that CspA as well as CspA-RNA complex is more stable at low temperature. It was also confirmed that RNP1 and RNP2 play key role in RNA binding. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CspA" title="CspA">CspA</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modelling" title=" homology modelling"> homology modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=mutation" title=" mutation"> mutation</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulation" title=" molecular dynamics simulation"> molecular dynamics simulation</a> </p> <a href="https://publications.waset.org/abstracts/78173/effect-of-low-temperature-on-structure-and-rna-binding-of-ecoli-cspa-a-molecular-dynamics-based-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78173.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">374</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1857</span> Surface Roughness Analysis, Modelling and Prediction in Fused Deposition Modelling Additive Manufacturing Technology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yusuf%20S.%20Dambatta">Yusuf S. Dambatta</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20A.%20D.%20Sarhan"> Ahmed A. D. Sarhan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fused deposition modelling (FDM) is one of the most prominent rapid prototyping (RP) technologies which is being used to efficiently fabricate CAD 3D geometric models. However, the process is coupled with many drawbacks, of which the surface quality of the manufactured RP parts is among. Hence, studies relating to improving the surface roughness have been a key issue in the field of RP research. In this work, a technique of modelling the surface roughness in FDM is presented. Using experimentally measured surface roughness response of the FDM parts, an ANFIS prediction model was developed to obtain the surface roughness in the FDM parts using the main critical process parameters that affects the surface quality. The ANFIS model was validated and compared with experimental test results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=surface%20roughness" title="surface roughness">surface roughness</a>, <a href="https://publications.waset.org/abstracts/search?q=fused%20deposition%20modelling%20%28FDM%29" title=" fused deposition modelling (FDM)"> fused deposition modelling (FDM)</a>, <a href="https://publications.waset.org/abstracts/search?q=adaptive%20neuro%20fuzzy%20inference%20system%20%28ANFIS%29" title=" adaptive neuro fuzzy inference system (ANFIS)"> adaptive neuro fuzzy inference system (ANFIS)</a>, <a href="https://publications.waset.org/abstracts/search?q=orientation" title=" orientation"> orientation</a> </p> <a href="https://publications.waset.org/abstracts/55529/surface-roughness-analysis-modelling-and-prediction-in-fused-deposition-modelling-additive-manufacturing-technology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">460</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1856</span> Building Information Modelling: A Review to Indian Scenario</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Agnivesh">P. Agnivesh</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20V.%20Ponambala%20Moorthi"> P. V. Ponambala Moorthi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Evolution of information modelling leads to the visualisation of well-organized built environment. Building Information Modelling (BIM) is considered as evolution in the off-site construction which essentially enhances and controls the present scenario of on-site construction paradigms. Promptness, sustainability and security are considered as the important characteristics of the building information modelling. Projects that uses BIM are tied firmly by technology but distributed organizationally. This allows different team members in the project to associate and integrate the works and work flows. This will in turn improve the efficiency of work breakdown structure. Internationally BIM had been accepted as modern computer aided way of information sharing by construction industry for efficient way of manipulation in order to avoid the on-site misperceptions. Even though, in developing countries like India BIM is in the phase of start and requires lot of mandates and policies to be brought about by the government for its widespread implementations. This paper reviews the current scenario of BIM worldwide and in India and suggests for the improved implementation of building modelling for Indian policy condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=building%20information%20modelling" title="building information modelling">building information modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=Indian%20polity" title=" Indian polity"> Indian polity</a>, <a href="https://publications.waset.org/abstracts/search?q=information%20modelling" title=" information modelling"> information modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=information%20sharing" title=" information sharing"> information sharing</a>, <a href="https://publications.waset.org/abstracts/search?q=mandates%20and%20policies" title=" mandates and policies"> mandates and policies</a>, <a href="https://publications.waset.org/abstracts/search?q=sustainability." title=" sustainability."> sustainability.</a> </p> <a href="https://publications.waset.org/abstracts/43108/building-information-modelling-a-review-to-indian-scenario" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43108.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1855</span> Genetic Programming: Principles, Applications and Opportunities for Hydrological Modelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Oluwaseun%20K.%20Oyebode">Oluwaseun K. Oyebode</a>, <a href="https://publications.waset.org/abstracts/search?q=Josiah%20A.%20Adeyemo"> Josiah A. Adeyemo </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrological modelling plays a crucial role in the planning and management of water resources, most especially in water stressed regions where the need to effectively manage the available water resources is of critical importance. However, due to the complex, nonlinear and dynamic behaviour of hydro-climatic interactions, achieving reliable modelling of water resource systems and accurate projection of hydrological parameters are extremely challenging. Although a significant number of modelling techniques (process-based and data-driven) have been developed and adopted in that regard, the field of hydrological modelling is still considered as one that has sluggishly progressed over the past decades. This is majorly as a result of the identification of some degree of uncertainty in the methodologies and results of techniques adopted. In recent times, evolutionary computation (EC) techniques have been developed and introduced in response to the search for efficient and reliable means of providing accurate solutions to hydrological related problems. This paper presents a comprehensive review of the underlying principles, methodological needs and applications of a promising evolutionary computation modelling technique – genetic programming (GP). It examines the specific characteristics of the technique which makes it suitable to solving hydrological modelling problems. It discusses the opportunities inherent in the application of GP in water related-studies such as rainfall estimation, rainfall-runoff modelling, streamflow forecasting, sediment transport modelling, water quality modelling and groundwater modelling among others. Furthermore, the means by which such opportunities could be harnessed in the near future are discussed. In all, a case for total embracement of GP and its variants in hydrological modelling studies is made so as to put in place strategies that would translate into achieving meaningful progress as it relates to modelling of water resource systems, and also positively influence decision-making by relevant stakeholders. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computational%20modelling" title="computational modelling">computational modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=evolutionary%20algorithms" title=" evolutionary algorithms"> evolutionary algorithms</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20programming" title=" genetic programming"> genetic programming</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrological%20modelling" title=" hydrological modelling"> hydrological modelling</a> </p> <a href="https://publications.waset.org/abstracts/5684/genetic-programming-principles-applications-and-opportunities-for-hydrological-modelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/5684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1854</span> Heat Transfer and Diffusion Modelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20Whalley">R. Whalley</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The heat transfer modelling for a diffusion process will be considered. Difficulties in computing the time-distance dynamics of the representation will be addressed. Incomplete and irrational Laplace function will be identified as the computational issue. Alternative approaches to the response evaluation process will be provided. An illustration application problem will be presented. Graphical results confirming the theoretical procedures employed will be provided. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heat" title="heat">heat</a>, <a href="https://publications.waset.org/abstracts/search?q=transfer" title=" transfer"> transfer</a>, <a href="https://publications.waset.org/abstracts/search?q=diffusion" title=" diffusion"> diffusion</a>, <a href="https://publications.waset.org/abstracts/search?q=modelling" title=" modelling"> modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=computation" title=" computation"> computation</a> </p> <a href="https://publications.waset.org/abstracts/22315/heat-transfer-and-diffusion-modelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22315.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">553</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1853</span> Isolation and Characterization White Spot Syndrome Protein Envelope Protein 19 from Black Tiger Shrimp (Penaeus monodon)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Andi%20Aliah%20Hidayani">Andi Aliah Hidayani</a>, <a href="https://publications.waset.org/abstracts/search?q=Asmi%20Citra%20Malina%20A.%20R.%20Tassakka"> Asmi Citra Malina A. R. Tassakka</a>, <a href="https://publications.waset.org/abstracts/search?q=Andi%20Parenrengi"> Andi Parenrengi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Vanname Shrimp is one of the high yielding varieties that are more resistant to virus attacks. However, now this shrimp more death due to virus attack such as white spot disease caused by white spot syndrome virus (WSSV). Various efforts have done to prevent the disease, like immunostimulatory, probiotics, and vaccine. White spot syndrome virus (WSSV) envelope protein VP19 gene is important because of its involvement in the system infection of shrimp. This study aimed to isolate and characterize an envelope protein VP19 – encoding gene of WSSV using WSSV infected Vanname Shrimp sample from some areas in South Sulawesi (Pangkep, Barru and Pinrang). The genomic of DNA were isolated from shrimp muscle using DTAB-CTAB method. Isolation of gene encoding envelope protein VP19 WSSV ws successfully performed with the results of the length of DNA fragment was 387 bp. The results of homology analysis using BLASTn homology suggested that these isolates genes from Barru, Pangkep and Pinrang have closest relationship with isolates from Mexican. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=vanname" title="vanname">vanname</a>, <a href="https://publications.waset.org/abstracts/search?q=shrimp" title=" shrimp"> shrimp</a>, <a href="https://publications.waset.org/abstracts/search?q=WSSV" title=" WSSV"> WSSV</a>, <a href="https://publications.waset.org/abstracts/search?q=viral%20protein%2019" title=" viral protein 19"> viral protein 19</a> </p> <a href="https://publications.waset.org/abstracts/20491/isolation-and-characterization-white-spot-syndrome-protein-envelope-protein-19-from-black-tiger-shrimp-penaeus-monodon" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20491.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">535</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1852</span> Identification of Cellulose-Hydrolytic Thermophiles Isolated from Sg. Klah Hot Spring Based on 16S rDNA Gene Sequence</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20J.%20Norashirene">M. J. Norashirene</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Zakiah"> Y. Zakiah</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Nurdiana"> S. Nurdiana</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Nur%20Hilwani"> I. Nur Hilwani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20H.%20Siti%20Khairiyah"> M. H. Siti Khairiyah</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20J.%20Muhamad%20Arif"> M. J. Muhamad Arif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, six bacterial isolates of a slightly thermophilic organism from the Sg. Klah hot spring, Malaysia were successfully isolated and designated as M7T55D1, M7T55D2, M7T55D3, M7T53D1, M7T53D2 and M7T53D3 respectively. The bacterial isolates were screened for their cellulose hydrolytic ability on Carboxymethlycellulose agar medium. The isolated bacterial strains were identified morphologically, biochemically and molecularly with the aid of 16S rDNA sequencing. All of the bacteria showed their optimum growth at a slightly alkaline pH of 7.5 with a temperature of 55°C. All strains were Gram-negative, non-spore forming type, strictly aerobic, catalase-positive and oxidase-positive with the ability to produce thermostable cellulase. Based on BLASTn results, bacterial isolates of M7T55D2 and M7T53D1 gave the highest homology (97%) with similarity to Tepidimonas ignava while isolates M7T55D1, M7T55D3, M7T53D2 and M7T53D3 showed their closest homology (97%-98%) with Tepidimonas thermarum. These cellulolytic thermophiles might have a commercial potential to produce valuable thermostable cellulase. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cellulase" title="cellulase">cellulase</a>, <a href="https://publications.waset.org/abstracts/search?q=cellulolytic" title=" cellulolytic"> cellulolytic</a>, <a href="https://publications.waset.org/abstracts/search?q=thermophiles" title=" thermophiles"> thermophiles</a>, <a href="https://publications.waset.org/abstracts/search?q=16S%20rDNA%20gene" title=" 16S rDNA gene"> 16S rDNA gene</a> </p> <a href="https://publications.waset.org/abstracts/13039/identification-of-cellulose-hydrolytic-thermophiles-isolated-from-sg-klah-hot-spring-based-on-16s-rdna-gene-sequence" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13039.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">345</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1851</span> Variable-Fidelity Surrogate Modelling with Kriging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Selvakumar%20Ulaganathan">Selvakumar Ulaganathan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivo%20Couckuyt"> Ivo Couckuyt</a>, <a href="https://publications.waset.org/abstracts/search?q=Francesco%20Ferranti"> Francesco Ferranti</a>, <a href="https://publications.waset.org/abstracts/search?q=Tom%20Dhaene"> Tom Dhaene</a>, <a href="https://publications.waset.org/abstracts/search?q=Eric%20Laermans"> Eric Laermans</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Variable-fidelity surrogate modelling offers an efficient way to approximate function data available in multiple degrees of accuracy each with varying computational cost. In this paper, a Kriging-based variable-fidelity surrogate modelling approach is introduced to approximate such deterministic data. Initially, individual Kriging surrogate models, which are enhanced with gradient data of different degrees of accuracy, are constructed. Then these Gradient enhanced Kriging surrogate models are strategically coupled using a recursive CoKriging formulation to provide an accurate surrogate model for the highest fidelity data. While, intuitively, gradient data is useful to enhance the accuracy of surrogate models, the primary motivation behind this work is to investigate if it is also worthwhile incorporating gradient data of varying degrees of accuracy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kriging" title="Kriging">Kriging</a>, <a href="https://publications.waset.org/abstracts/search?q=CoKriging" title=" CoKriging"> CoKriging</a>, <a href="https://publications.waset.org/abstracts/search?q=Surrogate%20modelling" title=" Surrogate modelling"> Surrogate modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=Variable-%20fidelity%20modelling" title=" Variable- fidelity modelling"> Variable- fidelity modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=Gradients" title=" Gradients"> Gradients</a> </p> <a href="https://publications.waset.org/abstracts/19031/variable-fidelity-surrogate-modelling-with-kriging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19031.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">558</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1850</span> Revealing the Structural and Dynamic Properties of Betaine Aldehyde Dehydrogenase 2 from Rice (Oryza sativa): Simulation Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Apisaraporn%20Baicharoen">Apisaraporn Baicharoen</a>, <a href="https://publications.waset.org/abstracts/search?q=Prapasiri%20Pongprayoon"> Prapasiri Pongprayoon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Betaine aldehyde dehydrogenase 2 (BADH2) is an enzyme that inhibits the accumulation of 2-acetyl-1-pyrroline (2AP), a potent flavor compound in rice fragrance. BADH2 contains three domains (NAD-binding, substrate-binding, and oligomerization domains). It catalyzes the oxidation of amino aldehydes. The lack of BADH2 results in the formation of 2AP and consequently an increase in rice fragrance. To date, inadequate data on BADH2 structure and function are available. An insight into the nature of BADH2 can serve as one of key starting points for the production of high quality fragrant rice. In this study, we therefore constructed the homology model of BADH2 and employed 500-ns Molecular Dynamics simulations (MD) to primarily understand the structural and dynamic properties of BADH2. Initially, Ramachandran plot confirms the good quality of modeled protein structure. Principle Component Analysis (PCA) was also calculated to capture the protein dynamics. Among 3 domains, the results show that NAD binding site is found to be more flexible. Moreover, interactions from key amino acids (N162, E260, C294, and Y419) that are crucial for function are investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=betaine%20aldehyde%20dehydrogenase%202" title="betaine aldehyde dehydrogenase 2">betaine aldehyde dehydrogenase 2</a>, <a href="https://publications.waset.org/abstracts/search?q=fragrant%20rice" title=" fragrant rice"> fragrant rice</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modeling" title=" homology modeling"> homology modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulations" title=" molecular dynamics simulations"> molecular dynamics simulations</a> </p> <a href="https://publications.waset.org/abstracts/54917/revealing-the-structural-and-dynamic-properties-of-betaine-aldehyde-dehydrogenase-2-from-rice-oryza-sativa-simulation-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54917.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">215</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1849</span> Building Information Modelling in Eastern Province Municipality of KSA</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Banan%20Aljumaiah">Banan Aljumaiah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, the construction industry has leveraged the information revolution, which makes it possible to view the entire construction process of new buildings before they are built with the advent of Building Information Modelling (BIM). Although BIM is an integration of the building model with the data and documents about the building, however, its implementation is limited to individual buildings missing the large picture of the city infrastructure. This limitation of BIM led to the birth of City Information Modelling. Three years ago, Eastern Province Municipality (EPM) in Saudi Arabia mandated that all major projects be delivered with collaborative 3D BIM. After three years of implementation, EPM started to implement City Information Modelling (CIM) as a part of the Smart City Plan to link infrastructure and public services and modelling how people move around and interact with the city. This paper demonstrates a local case study of BIM implementation in EPM and its future as a part of project management automation; the paper also highlights the ambitious plan of EPM to transform CIM towards building smart cities. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BIM" title="BIM">BIM</a>, <a href="https://publications.waset.org/abstracts/search?q=BIM%20to%20CIM" title=" BIM to CIM"> BIM to CIM</a> </p> <a href="https://publications.waset.org/abstracts/154926/building-information-modelling-in-eastern-province-municipality-of-ksa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1848</span> Drawing, Design and Building Information Modelling (BIM): Embedding Advanced Digital Tools in the Academy Programs for Building Engineers and Architects</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vittorio%20Caffi">Vittorio Caffi</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Pignataro"> Maria Pignataro</a>, <a href="https://publications.waset.org/abstracts/search?q=Antonio%20Cosimo%20Devito"> Antonio Cosimo Devito</a>, <a href="https://publications.waset.org/abstracts/search?q=Marco%20Pesenti"> Marco Pesenti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper deals with the integration of advanced digital design and modelling tools and methodologies, known as Building Information Modelling, into the traditional Academy educational programs for building engineers and architects. Nowadays, the challenge the Academy has to face is to present the new tools and their features to the pupils, making sure they acquire the proper skills in order to leverage the potential they offer also for the other courses embedded in the educational curriculum. The syllabus here presented refers to the “Drawing for building engineering”, “2D and 3D laboratory” and “3D modelling” curricula of the MSc in Building Engineering of the Politecnico di Milano. Such topics, included since the first year in the MSc program, are fundamental to give the students the instruments to master the complexity of an architectural or building engineering project with digital tools, so as to represent it in its various forms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BIM" title="BIM">BIM</a>, <a href="https://publications.waset.org/abstracts/search?q=BIM%20curricula" title=" BIM curricula"> BIM curricula</a>, <a href="https://publications.waset.org/abstracts/search?q=computational%20design" title=" computational design"> computational design</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20modelling" title=" digital modelling"> digital modelling</a> </p> <a href="https://publications.waset.org/abstracts/61335/drawing-design-and-building-information-modelling-bim-embedding-advanced-digital-tools-in-the-academy-programs-for-building-engineers-and-architects" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61335.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">669</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1847</span> Microkinetic Modelling of NO Reduction on Pt Catalysts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vishnu%20S.%20Prasad">Vishnu S. Prasad</a>, <a href="https://publications.waset.org/abstracts/search?q=Preeti%20Aghalayam"> Preeti Aghalayam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The major harmful automobile exhausts are nitric oxide (NO) and unburned hydrocarbon (HC). Reduction of NO using unburned fuel HC as a reductant is the technique used in hydrocarbon-selective catalytic reduction (HC-SCR). In this work, we study the microkinetic modelling of NO reduction using propene as a reductant on Pt catalysts. The selectivity of NO reduction to N<sub>2</sub>O is detected in some ranges of operating conditions, whereas the effect of inlet O<sub>2</sub>% causes a number of changes in the feasible regimes of operation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microkinetic%20modelling" title="microkinetic modelling">microkinetic modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=NOx" title=" NOx"> NOx</a>, <a href="https://publications.waset.org/abstracts/search?q=platinum%20on%20alumina%20catalysts" title=" platinum on alumina catalysts"> platinum on alumina catalysts</a>, <a href="https://publications.waset.org/abstracts/search?q=selective%20catalytic%20reduction" title=" selective catalytic reduction"> selective catalytic reduction</a> </p> <a href="https://publications.waset.org/abstracts/53965/microkinetic-modelling-of-no-reduction-on-pt-catalysts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53965.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1846</span> On Mathematical Modelling and Optimization of Emerging Trends Processes in Advanced Manufacturing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Agarana%20Michael%20C.">Agarana Michael C.</a>, <a href="https://publications.waset.org/abstracts/search?q=Akinlabi%20Esther%20T."> Akinlabi Esther T.</a>, <a href="https://publications.waset.org/abstracts/search?q=Pule%20Kholopane"> Pule Kholopane</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Innovation in manufacturing process technologies and associated product design affects the prospects for manufacturing today and in near future. In this study some theoretical methods, useful as tools in advanced manufacturing, are considered. In particular, some basic Mathematical, Operational Research, Heuristic, and Statistical techniques are discussed. These techniques/methods are very handy in many areas of advanced manufacturing processes, including process planning optimization, modelling and analysis. Generally the production rate requires the application of Mathematical methods. The Emerging Trends Processes in Advanced Manufacturing can be enhanced by using Mathematical Modelling and Optimization techniques. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mathematical%20modelling" title="mathematical modelling">mathematical modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=optimization" title=" optimization"> optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=emerging%20trends" title=" emerging trends"> emerging trends</a>, <a href="https://publications.waset.org/abstracts/search?q=advanced%20manufacturing" title=" advanced manufacturing"> advanced manufacturing</a> </p> <a href="https://publications.waset.org/abstracts/158822/on-mathematical-modelling-and-optimization-of-emerging-trends-processes-in-advanced-manufacturing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158822.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">297</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1845</span> Early Requirement Engineering for Design of Learner Centric Dynamic LMS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kausik%20Halder">Kausik Halder</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabendu%20Chaki"> Nabendu Chaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Ranjan%20Dasgupta"> Ranjan Dasgupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We present a modelling framework that supports the engineering of early requirements specifications for design of learner centric dynamic Learning Management System. The framework is based on i* modelling tool and Means End Analysis, that adopts primitive concepts for modelling early requirements (such as actor, goal, and strategic dependency). We show how pedagogical and computational requirements for designing a learner centric Learning Management system can be adapted for the automatic early requirement engineering specifications. Finally, we presented a model on a Learner Quanta based adaptive Courseware. Our early requirement analysis shows that how means end analysis reveals gaps and inconsistencies in early requirements specifications that are by no means trivial to discover without the help of formal analysis tool. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adaptive%20courseware" title="adaptive courseware">adaptive courseware</a>, <a href="https://publications.waset.org/abstracts/search?q=early%20requirement%20engineering" title=" early requirement engineering"> early requirement engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=means%20end%20analysis" title=" means end analysis"> means end analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=organizational%20modelling" title=" organizational modelling"> organizational modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=requirement%20modelling" title=" requirement modelling"> requirement modelling</a> </p> <a href="https://publications.waset.org/abstracts/8626/early-requirement-engineering-for-design-of-learner-centric-dynamic-lms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8626.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">500</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1844</span> Stem Covers of Leibniz n-Algebras</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nat%C3%A1lia%20Maria%20Rego">Natália Maria Rego</a> </p> <p class="card-text"><strong>Abstract:</strong></p> ALeibnizn-algebraGis aK-vector space endowed whit a n-linearbracket operation [-,…-] : GG … G→ Gsatisfying the fundamental identity, which can be expressed saying that the right multiplication map Ry2, …, ᵧₙ: Gn→ G, Rᵧ₂, …, ᵧₙn(ˣ¹, …, ₓₙ) = [[ˣ¹, …, ₓₙ], ᵧ₂, …, ᵧₙ], is a derivation. This structure, together with its skew-symmetric version, named as Lie n-algebra or Filippov algebra, arose in the setting of Nambumechanics, an n-ary generalization of the Hamiltonian mechanics. Thefirst goal of this work is to provide a characterization of various classes of central extensions of Leibniz n-algebras in terms of homological properties. Namely, Commutator extension, Quasi-commutator extension, Stem extension, and Stem cover. These kind of central extensions are characterized by means of the character of the map *(E): nHL1(G) → M provided by the five-term exact sequence in homology with trivial coefficients of Leibniz n-algebras associated to an extension E : 0 → M → K → G → 0. For a free presentation 0 →R→ F →G→ 0of a Leibniz n-algebra G,the term M(G) = (R[F,…n.., F])/[R, F,..n-1..,F] is called the Schur multiplier of G, which is a Baer invariant, i.e., it does not depend on the chosen free presentation, and it is isomorphic to the first Leibniz n-algebras homology with trivial coefficients of G. A central extension of Leibniz n-algebras is a short exact sequenceE : 0 →M→K→G→ 0such that [M, K,.. ⁿ⁻¹.., K]=0. It is said to be a stem extension if M⊆[G, .. n.., G]. Additionally, if the induced map M(K) → M(G) is the zero map, then the stem extension Eis said to be a stem cover. The second aim of this work is to analyze the interplay between stem covers of Leibniz n-algebras and the Schur multiplier. Concretely, in the case of finite-dimensional Leibniz n-algebras, we show the existence of coverings, and we prove that all stem covers with finite-dimensional Schur multiplier are isoclinic. Additionally, we characterize stem covers of perfect Leibniz n-algebras. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=leibniz%20n-algebras" title="leibniz n-algebras">leibniz n-algebras</a>, <a href="https://publications.waset.org/abstracts/search?q=central%20extensions" title=" central extensions"> central extensions</a>, <a href="https://publications.waset.org/abstracts/search?q=Schur%20multiplier" title=" Schur multiplier"> Schur multiplier</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cover" title=" stem cover"> stem cover</a> </p> <a href="https://publications.waset.org/abstracts/140090/stem-covers-of-leibniz-n-algebras" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140090.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">157</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1843</span> Prediction of Energy Storage Areas for Static Photovoltaic System Using Irradiation and Regression Modelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kisan%20Sarda">Kisan Sarda</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhavika%20Shingote"> Bhavika Shingote</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper aims to evaluate regression modelling for prediction of Energy storage of solar photovoltaic (PV) system using Semi parametric regression techniques because there are some parameters which are known while there are some unknown parameters like humidity, dust etc. Here irradiation of solar energy is different for different places on the basis of Latitudes, so by finding out areas which give more storage we can implement PV systems at those places and our need of energy will be fulfilled. This regression modelling is done for daily, monthly and seasonal prediction of solar energy storage. In this, we have used R modules for designing the algorithm. This algorithm will give the best comparative results than other regression models for the solar PV cell energy storage. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=semi%20parametric%20regression" title="semi parametric regression">semi parametric regression</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltaic%20%28PV%29%20system" title=" photovoltaic (PV) system"> photovoltaic (PV) system</a>, <a href="https://publications.waset.org/abstracts/search?q=regression%20modelling" title=" regression modelling"> regression modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=irradiation" title=" irradiation"> irradiation</a> </p> <a href="https://publications.waset.org/abstracts/65373/prediction-of-energy-storage-areas-for-static-photovoltaic-system-using-irradiation-and-regression-modelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65373.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">381</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1842</span> Software Engineering Inspired Cost Estimation for Process Modelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Felix%20Baumann">Felix Baumann</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandar%20Milutinovic"> Aleksandar Milutinovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Dieter%20Roller"> Dieter Roller</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Up to this point business process management projects in general and business process modelling projects in particular could not rely on a practical and scientifically validated method to estimate cost and effort. Especially the model development phase is not covered by a cost estimation method or model. Further phases of business process modelling starting with implementation are covered by initial solutions which are discussed in the literature. This article proposes a method of filling this gap by deriving a cost estimation method from available methods in similar domains namely software development or software engineering. Software development is regarded as closely similar to process modelling as we show. After the proposition of this method different ideas for further analysis and validation of the method are proposed. We derive this method from COCOMO II and Function Point which are established methods of effort estimation in the domain of software development. For this we lay out similarities of the software development rocess and the process of process modelling which is a phase of the Business Process Management life-cycle. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=COCOMO%20II" title="COCOMO II">COCOMO II</a>, <a href="https://publications.waset.org/abstracts/search?q=busines%20process%20modeling" title=" busines process modeling"> busines process modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=cost%20estimation%20method" title=" cost estimation method"> cost estimation method</a>, <a href="https://publications.waset.org/abstracts/search?q=BPM%20COCOMO" title=" BPM COCOMO"> BPM COCOMO</a> </p> <a href="https://publications.waset.org/abstracts/41029/software-engineering-inspired-cost-estimation-for-process-modelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41029.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">440</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=homology%20modelling&amp;page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=homology%20modelling&amp;page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=homology%20modelling&amp;page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=homology%20modelling&amp;page=5">5</a></li> <li class="page-item"><a class="page-link" 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