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<h1>Prostanoid Receptors</h1> <p><strong>Prostanoid receptors</strong> are activated by the endogenous ligands prostaglandin (PG) D<sub>2</sub>, PGE<sub>2</sub>, PGF<sub>2α</sub>, PGH<sub>2</sub>, prostacyclin (PGI<sub>2</sub>) and thromboxane A<sub>2</sub>. <a href='/pharmacology/cyclooxygenases' title='Browse products for cyclooxygenases'>Cyclooxygenase (COX)</a> converts arachidonic acid to PGH<sub>2</sub>, from which the other prostaglandins are synthesized.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Products</span></div> <div class="tab tab_2" data-tab="2" data-tabname="background" id="pharm_tabs_background"><span>Background</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="gene" id="pharm_tabs_gene"> <span>Gene Data</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_products"><table class="pharm_prod_table table table-condensed"> <tr> <th colspan="2"><h3><a href="/pharmacology/prostanoid-receptors/agonists" title="View all Prostanoid Receptor Agonist products">Prostanoid Receptor Agonists</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>4027</td> <td><a href="/products/16-16-dimethyl-prostaglandin-e2_4027" title="View price & availability information for 16,16-Dimethyl Prostaglandin E2">16,16-Dimethyl Prostaglandin E2</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Synthetic <a href='/products/prostaglandin-e2_2296'>prostaglandin E<sub>2</sub></a> (Cat. No. 2296) derivative; regulates HSC development</td> </tr> <tr> <td>2989</td> <td><a href="/products/epoprostenol_2989" title="View price & availability information for Epoprostenol">Epoprostenol</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Endogenous IP receptor agonist</td> </tr> <tr> <td>2296</td> <td><a href="/products/prostaglandin-e2_2296" title="View price & availability information for Prostaglandin E2">Prostaglandin E<sub>2</sub></a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin</td> </tr> <tr> <td>4214</td> <td><a href="/products/prostaglandin-f2-alpha_4214" title="View price & availability information for Prostaglandin F2alpha">Prostaglandin F<sub>2伪</sub></a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Naturally-occurring prostanoid; potent vasoconstrictor</td> </tr> <tr> <td>4069</td> <td><a href="/products/tcs-2510_4069" title="View price & availability information for TCS 2510">TCS 2510</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective EP<sub>4</sub> agonist</td> </tr> <tr> <td>5349</td> <td><a href="/products/treprostinil_5349" title="View price & availability information for Treprostinil">Treprostinil</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent prostacyclin (PGI<sub>2</sub>) analog</td> </tr> <tr> <td>1932</td> <td><a href="/products/u-46619_1932" title="View price & availability information for U 46619">U 46619</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent, stable thromboxane A<sub>2</sub> (TP) receptor agonist</td> </tr> <tr> <th colspan="2"><h3><a href="/pharmacology/prostanoid-receptors/antagonists" title="View all Prostanoid Receptor Antagonist products">Prostanoid Receptor Antagonists</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>5701</td> <td><a href="/products/amg-853_5701" title="View price & availability information for AMG 853">AMG 853</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent dual CRTH2 and prostaglandin D<sub>2</sub> (PGD<sub>2</sub>) receptor antagonist</td> </tr> <tr> <td>2732</td> <td><a href="/products/bay-u-3405_2732" title="View price & availability information for BAY-u 3405">BAY-u 3405</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Dual TP/DP<sub>2</sub> (CRTH2) receptor antagonist</td> </tr> <tr> <td>5327</td> <td><a href="/products/bgc-20-1531-hydrochloride_5327" title="View price & availability information for BGC 20-1531 hydrochloride">BGC 20-1531 hydrochloride</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>High affinity and selective EP<sub>4</sub> antagonist</td> </tr> <tr> <td>6240</td> <td><a href="/products/dg-041_6240" title="View price & availability information for DG 041">DG 041</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective EP<sub>3</sub> antagonist; antiplatelet and antithrombotic</td> </tr> <tr> <td>2514</td> <td><a href="/products/l-161-982_2514" title="View price & availability information for L-161,982">L-161,982</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective EP<sub>4</sub> receptor antagonist</td> </tr> <tr> <td>3342</td> <td><a href="/products/l-798-106_3342" title="View price & availability information for L-798,106">L-798,106</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and highly selective EP<sub>3</sub> antagonist</td> </tr> <tr> <td>7343</td> <td><a href="/products/laropiprant_7343" title="View price & availability information for Laropiprant">Laropiprant</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective prostaglandin D<sub>2</sub> receptor antagonist</td> </tr> <tr> <td>5406</td> <td><a href="/products/ono-8130_5406" title="View price & availability information for ONO 8130">ONO 8130</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>EP<sub>1</sub> receptor antagonist</td> </tr> <tr> <td>3565</td> <td><a href="/products/ono-ae3-208_3565" title="View price & availability information for ONO AE3 208">ONO AE3 208</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>High affinity and selective EP<sub>4</sub> antagonist</td> </tr> <tr> <td>4818</td> <td><a href="/products/pf-04418948_4818" title="View price & availability information for PF 04418948">PF 04418948</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective EP<sub>2</sub> receptor antagonist</td> </tr> <tr> <td>5568</td> <td><a href="/products/s-18886_5568" title="View price & availability information for S 18886">S 18886</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent thromboxane A<sub>2</sub> (TP) antagonist</td> </tr> <tr> <td>1206</td> <td><a href="/products/sc-19220_1206" title="View price & availability information for SC 19220">SC 19220</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective EP<sub>1</sub> receptor antagonist</td> </tr> <tr> <td>2791</td> <td><a href="/products/sc-51322_2791" title="View price & availability information for SC 51322">SC 51322</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent EP<sub>1</sub> receptor antagonist</td> </tr> <tr> <th colspan="2"><h3><a href="/pharmacology/prostanoid-receptors/other" title="View all Prostanoid Receptor Other products">Other</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>1620</td> <td><a href="/products/alprostadil_1620" title="View price & availability information for Alprostadil">Alprostadil</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Prostaglandin. Vasodilator and antiplatelet agent <em>in vivo</em></td> </tr></table></div> <div class="pharm_rel_cats"><h3>Related Targets</h3><ul class="tile_column_1"><li><a href="/pharmacology/cyclooxygenases" title="Browse products for Cyclooxygenases">Cyclooxygenases</a></li></ul><ul class="tile_column_2"></ul></div> </div> <div class="tab_content tab_2" data-tab="2"> <p><strong>Prostanoid receptors</strong> are activated by the endogenous ligands prostaglandin (PG) D<sub>2</sub>, PGE<sub>2</sub>, PGF<sub>2α</sub>, PGH<sub>2</sub>, prostacyclin (PGI<sub>2</sub>) and thromboxane A<sub>2</sub>. <a href='/pharmacology/cyclooxygenases' title='Browse products for cyclooxygenases'>Cyclooxygenase (COX)</a> converts arachidonic acid to PGH<sub>2</sub>, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions.</p> <ol> <li>DP receptors (DP<sub>1-2</sub>) are coupled to G<sub>αs</sub>. They are expressed in the small intestine, lung, stomach and uterus. Activation of DP<sub>1</sub> results in inhibition of platelet activation and vasodilation; they are also involved in sleep regulation. DP<sub>2</sub> activation leads to immune cell activation. <li>EP receptors (EP<sub>1-4</sub>) are a diverse group of prostanoid receptors. EP<sub>1</sub> receptors are restricted to the kidney, lung and stomach, and induce smooth muscle contraction. EP<sub>2</sub> and EP<sub>4</sub> couple to G<sub>αs</sub> and induce smooth muscle relaxation. EP<sub>3</sub> is an inhibitory receptor that prevents smooth muscle relaxation. <li>FP receptors are coupled to G<sub>αq</sub>. They are abundant in the corpus luteum, where they are involved in luteolysis. <li>IP receptors are coupled to G<sub>αs</sub> and are involved in pain mediation, relaxation of vascular smooth muscle, inhibition of <a href='/research-area/thrombosis-and-hemostasis-research' title='Browse products for Thrombosis & Hemostasis'>platelet aggregation</a> and they contribute to cardiovascular health. <li>TP receptors can be coupled to both G<sub>αq</sub> and G<sub>αi</sub>. They are expressed abundantly in highly vascular tissues such as the kidney and heart, and immune-related organs such as the thymus and spleen. They mediate smooth muscle contraction and platelet aggregation. </ol><h3>External sources of pharmacological information for Prostanoid Receptors : </h3><ul class="tile_column_1"><li><a href="https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=58" target="_blank" rel="nofollow">IUPHAR Receptor Code</a></li></ul><ul class="tile_column_2"><li><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13878" target="_blank" rel="nofollow">BJP Guide</a></li></ul> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> <H3>Prostanoid Receptor Gene Data</H3> <table class="table table-responsive"> <tr> <th style='width:21%' title='Gene'> Gene </th> <th style='width:13%' title='Species'> Species </th> <th style='width:16%' title='The official gene symbol that has been approved by the HGNC'> Gene Symbol </th> <th style='width:25%' title='A unique identifier for a gene sequence record from the Reference Sequence database'> Gene Accession No. </th> <th style='width:25%' title='A unique identifier for a protein sequence record from the UniProt Protein Knowledgebase'> Protein Accession No. </th> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> EP<sub>1</sub> </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9593' target='_blank'>PTGER1</a> </td> <td style='width:25%'> NM_000955 </td> <td style='width:25%'> P34995 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=12688' target='_blank'>Ptger1</a> </td> <td> NM_013641 </td> <td> P35375 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3434' target='_blank'>Ptger1</a> </td> <td> NM_013100 </td> <td> P70597 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> EP<sub>2</sub> </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9594' target='_blank'>PTGER2</a> </td> <td> NM_000956 </td> <td> P43116 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=12689' target='_blank'>Pyry2</a> </td> <td> NM_008964 </td> <td> Q62053 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=620020' target='_blank'>Ptger2</a> </td> <td> NM_031088 </td> <td> Q62928 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> EP<sub>3</sub> </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9595' target='_blank'>PTGER3</a> </td> <td> NM_000957 </td> <td> P43115 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=12690' target='_blank'>Ptger3</a> </td> <td> NM_011196 </td> <td> P30557 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3435' target='_blank'>Ptger3</a> </td> <td> NM_012704 </td> <td> P34980 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> EP<sub>4</sub> </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9596' target='_blank'>PTGER4</a> </td> <td> NM_000958 </td> <td> P35408 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=24307' target='_blank'>Ptger4</a> </td> <td> NM_008965 </td> <td> P32240 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=628641' target='_blank'>Ptger4</a> </td> <td> NM_032076 </td> <td> P43114 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> TP </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11608' target='_blank'>TBXA2R</a> </td> <td> NM_201636 </td> <td> P21731 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=13765' target='_blank'>Tbxa2r</a> </td> <td> NM_009325 </td> <td> P30987 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3825' target='_blank'>Tbxa2r</a> </td> <td> NM_017054 </td> <td> P34978 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> FP </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9600' target='_blank'>PTGFR</a> </td> <td> NM_000959 </td> <td> P43088 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=12691' target='_blank'>Ptgfr</a> </td> <td> NM_008966 </td> <td> P43117 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3436' target='_blank'>Ptgfr</a> </td> <td> NM_013115 </td> <td> P43118 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> IP </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9602' target='_blank'>PTGIR</a> </td> <td> NM_000960 </td> <td> P43119 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=15352' target='_blank'>Ptgir</a> </td> <td> NM_008967 </td> <td> P43252 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1310890' target='_blank'>Ptgir</a> </td> <td> NM_001077644 </td> <td> P43253 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> DP </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9591' target='_blank'>PTGDR</a> </td> <td> NM_000953 </td> <td> Q13258 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=22868' target='_blank'>Ptgdr</a> </td> <td> NM_008962 </td> <td> P70263 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=619707' target='_blank'>Ptgdr</a> </td> <td> NM_022241 </td> <td> O35932 </td> </tr> </table> <h3>Pathway of Prostanoid Production</h3> <div class='text-center'><img src='https://resources.tocris.com/images/targets/prostanoid.jpg' height='288' style='width:300' alt='Pathway of Prostanoid Production'></div> <h3>Prostanoid Receptor Pharmacological Data</h3> <table class="table table-responsive"> <tr> <th style="width:20%"> Receptor Subtype </th> <th style="width:20%"> EP<sub>1</sub> </th> <th style="width:20%"> EP<sub>2</sub> </th> <th style="width:20%"> EP<sub>3</sub> </th> <th style="width:20%"> EP<sub>4</sub> </th> </tr> <tr> <td style="width:20%" class='pb_bld'> Transduction Mechanism </td> <td style="width:20%"> G<sub>q</sub> → ↑ PI hydrolysis/Ca<sup>2+</sup> </td> <td style="width:20%"> G<sub>s</sub> → ↑ cAMP </td> <td style="width:20%"> Various (splice variants), mainly ↓ cAMP </td> <td style="width:20%"> G<sub>s</sub> → ↑ cAMP </td> </tr> <tr> <td class='pb_bld'> Agonist Potencies </td> <td> PGE<sub>2</sub> > PGF<sub>2</sub>, PGI<sub>2</sub> > PGD<sub>2</sub>, TXA<sub>2</sub> </td> <td> PGE<sub>2</sub> > PGF<sub>2</sub>, PGI<sub>2</sub> > PGD<sub>2</sub>, TXA<sub>2</sub> </td> <td> PGE<sub>2</sub> > PGF<sub>2</sub>, PGI<sub>2</sub> > PGD<sub>2</sub>, TXA<sub>2</sub> </td> <td> PGE<sub>2</sub> > PGF<sub>2</sub>, PGI<sub>2</sub> > PGD<sub>2</sub>, TXA<sub>2</sub> </td> </tr> <tr> <td class='pb_bld'> Receptor Distribution </td> <td> Kidney, lung (mouse) </td> <td> Lung, placenta (human), uterus, lung, ileum, liver, thymus, spleen (mouse) </td> <td> Kidney, uterus, stomach, brain, thymus, lung, spleen (mouse), kidney, pancreas, uterus, heart, liver, testis, ovary (human) </td> <td> Ileum, thymus, spleen, lung, heart, stomach, uterus (mouse) </td> </tr> <tr> <td class='pb_bld'> Tissue Functions </td> <td> GI contraction, tracheal contraction (guinea-pig), gastric fundus contraction </td> <td> Bronchodilatation (guinea-pig, cat), myometrial inhibition (human,baboon), vasodepression (cat, guinea-pig) </td> <td> Inhibition of gastric acid secretion (human, dog, rat), myometrial stimulation (human, cat,rat, hamster) </td> <td> Vasodilatation (dog), bronchodilatation (rat) </td> </tr> </table> <br> <table class="table table-responsive"> <tr> <th style="width:20%"> Receptor Subtype </th> <th style="width:20%"> DP </th> <th style="width:20%"> FP </th> <th style="width:20%"> IP </th> <th style="width:20%"> TP </th> </tr> <tr> <td style="width:20%" class='pb_bld'> Transduction Mechanism </td> <td style="width:20%"> G<sub>s</sub> → ↑ cAMP </td> <td style="width:20%"> G<sub>q</sub> → ↑ PI hydrolysis/Ca<sup>2+</sup> </td> <td style="width:20%"> G<sub>s</sub> → ↑ cAMP<br> ↑ PI hydrolysis/Ca<sup>2+</sup> </td> <td style="width:20%"> G<sub>q</sub> → ↑ PI hydrolysis/Ca<sup>2+</sup> </td> </tr> <tr> <td class='pb_bld'> Agonist Potencies </td> <td> PGD<sub>2</sub> >> PGE<sub>2</sub> > PGF<sub>2</sub> > PGI<sub>2</sub>, TXA<sub>2</sub> </td> <td> PGF<sub>2</sub> > PGD<sub>2</sub> > PGE<sub>2</sub> > PGI<sub>2</sub>, TXA<sub>2</sub> </td> <td> PGI<sub>2</sub> >> PGD<sub>2</sub> ,PGE<sub>2</sub>, PGF<sub>2</sub> > TXA<sub>2</sub> </td> <td> TXA<sub>2</sub> = PGH<sub>2</sub> >> PGD<sub>2</sub>, PGE<sub>2</sub>, PGF<sub>2</sub>, PGI<sub>2</sub> </td> </tr> <tr> <td class='pb_bld'> Receptor Distribution </td> <td> Ileum, lung, stomach, uterus (mouse) </td> <td> Corpus luteum, kidney, lung, heart, stomach (mouse), overy, small intestine, prostate, spleen, testis (human) </td> <td> Aorta, lung, heart, kidney (human), thymus, spleen (mouse), NTS, dorsal horn (rat) </td> <td> Thymus, spleen, lung, kidney, heart, uterus (mouse) </td> </tr> <tr> <td class='pb_bld'> Tissue Functions </td> <td> Inhibition of platelet aggregation </td> <td> Luteolysis </td> <td> Vasodepression, inhibition of platelet aggregation </td> <td> Vaso- and bronchoconstriction, platelet aggregation, myometrial stimulation </td> </tr> </table> <h3>References</h3> <p>IUPHAR Compendium of receptor characterization and classification. (2000) 2nd Edition. IUPHAR Media. <strong>Breyer</strong> <em>et al</em> (2001) Prostanoid receptors: subtypes and signaling. Ann.Rev.Pharmacol.Toxicol. <strong><em>41</em></strong> 661.</p> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br /> Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO</div> <div 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