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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Diagnostic radiotracer</div> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output .ambox+link+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+style+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+link+.ambox{margin-top:-1px}html body.mediawiki .mw-parser-output .ambox.mbox-small-left{margin:4px 1em 4px 0;overflow:hidden;width:238px;border-collapse:collapse;font-size:88%;line-height:1.25em}.mw-parser-output .ambox-speedy{border-left:10px solid #b32424;background-color:#fee7e6}.mw-parser-output .ambox-delete{border-left:10px solid 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Please discuss further on the <a href="/wiki/Talk:Florbetaben_(18F)" title="Talk:Florbetaben (18F)">talk page</a>.</span> <span class="date-container"><i>(<span class="date">March 2018</span>)</i></span><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Florbetaben (<sup>18</sup>F)">Florbetaben (<sup>18</sup>F)</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Florbetaben_F18.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Florbetaben_F18.svg/220px-Florbetaben_F18.svg.png" decoding="async" width="220" height="68" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Florbetaben_F18.svg/330px-Florbetaben_F18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Florbetaben_F18.svg/440px-Florbetaben_F18.svg.png 2x" data-file-width="2465" data-file-height="760" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Neuraceq</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">BAY-949172</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/pro/neuraceq.html">FDA Professional Drug Information</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Florbetaben">Florbetaben</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_V09" title="ATC code V09">V09AX06</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=V09AX06">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-Neuraceq_FDA_label_2-0" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">4-{(<i>E</i>)-2-[4-(2-{2-[2-(<sup>18</sup>F)Fluoroethoxy]ethoxy}ethoxy)phenyl]vinyl}-<i>N</i>-methylaniline</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=902143-01-5">902143-01-5</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/11501341">11501341</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.9676143.html">9676143</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/TLA7312TOI">TLA7312TOI</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:79033">CHEBI:79033</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID20238065">DTXSID20238065</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q17014149#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data">C<sub>21</sub>H<sub>26</sub><sup>18</sup>FNO<sub>3</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data">358.44 g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CNC1%3DCC%3DC%28C%3DC1%29%2FC%3DC%2FC2%3DCC%3DC%28C%3DC2%29OCCOCCOCC%5B18F%5D">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CNC1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)OCCOCCOCC[18F]</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C21H26FNO3/c1-23-20-8-4-18(5-9-20)2-3-19-6-10-21(11-7-19)26-17-16-25-15-14-24-13-12-22/h2-11,23H,12-17H2,1H3/b3-2+/i22-1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:NCWZOASIUQVOFA-FWZJPQCDSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Florbetaben</b>, sold under the brand name <b>Neuraceq</b>, is a diagnostic <a href="/wiki/Radiotracer" class="mw-redirect" title="Radiotracer">radiotracer</a> developed for routine clinical application to visualize <a href="/wiki/%CE%92-amyloid" class="mw-redirect" title="Β-amyloid">β-amyloid</a> plaques in the brain. It is a <a href="/wiki/Fluorine-18" title="Fluorine-18">fluorine-18</a> (<sup>18</sup>F)-labeled <a href="/wiki/Stilbene" title="Stilbene">stilbene</a> derivative. </p><p>Florbetaben was approved for medical use in the European Union, the United States, and South Korea in 2014.<sup id="cite_ref-Neuraceq_FDA_label_2-1" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EU_4-0" class="reference"><a href="#cite_note-EU-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Florbetaben_(18F)&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Florbetaben is <a href="/wiki/Indicated" class="mw-redirect" title="Indicated">indicated</a> for <a href="/wiki/Positron_Emission_Tomography" class="mw-redirect" title="Positron Emission Tomography">Positron Emission Tomography</a> (PET) imaging of β-amyloid neuritic plaque density in the brains of adults with <a href="/wiki/Cognitive_impairment" title="Cognitive impairment">cognitive impairment</a> who are being evaluated for <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a> (AD) and other causes of cognitive impairment. </p> <div class="mw-heading mw-heading2"><h2 id="Alzheimer's_disease_and_amyloid-beta_PET_imaging"><span id="Alzheimer.27s_disease_and_amyloid-beta_PET_imaging"></span>Alzheimer's disease and amyloid-beta PET imaging</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Florbetaben_(18F)&action=edit&section=2" title="Edit section: Alzheimer's disease and amyloid-beta PET imaging"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The deposition of β-amyloid is considered as one hallmark in the pathogenesis of AD,<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and most likely begins years before the onset of detectable cognitive symptoms.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Clinical testing using neuropsychology or memory examinations is the standard tool to diagnose AD as clinically possible or probable. Confirmation of the clinical diagnosis requires the identification of β-amyloid plaques in the brain. Until recently, this was only possible after death, in postmortem histopathology. The need of diagnosis confirmation during life has led to the development and incorporation of biomarkers, such as cerebrospinal fluid and amyloid imaging markers, as supplementary tools to facilitate clinical testing in the workflow of AD diagnosis.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>When used in conjunction with other clinical tests, florbetaben can assist in the diagnosis of AD by detecting the presence or absence of β-amyloid plaques. This is particularly relevant at the prodromal AD stage of mild cognitive impairment (MCI) and at the dementia stage of this disease, where clinical tests lack accuracy to establish a trustworthy AD diagnosis.<sup id="cite_ref-Beach_11-0" class="reference"><a href="#cite_note-Beach-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Development_program">Development program</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Florbetaben_(18F)&action=edit&section=3" title="Edit section: Development program"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Florbetaben binding to β-amyloid plaques on human brain samples was originally demonstrated in 2005.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Highly selective binding for β-amyloid over other proteins (e.g., tau and a-synuclein) has been demonstrated in vitro.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Initial single-center studies demonstrated the potential for florbetaben PET imaging to discriminate between AD patients and non-AD patients or healthy volunteers.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Single dose pharmacokinetics of 300 MBq florbetaben of low or high mass dose (<=5 and 50–55 μg) showed no relevant differences between Japanese and Caucasian populations.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> When compared to healthy subjects, cortical uptake of florbetaben was demonstrated to be generally higher in a large proportion of patients with a clinical diagnosis of AD or mild cognitive impairment.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Longitudinal data of 45 patients with MCI indicated that florbetaben PET imaging may be useful to identify patients who will progress to AD.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> A substantial proportion of patients with a positive florbetaben PET scan progressed to AD-dementia over a 2-year and 4-year time frame. At 4-year follow-up, 88% (21/24) of individuals with MCI and positive florbetaben uptake converted to clinical dementia due to AD, whereas none of 21 florbetaben-negative individuals with MCI experienced a conversion. The pivotal phase III study investigated the relationship of florbetaben imaging and amyloid deposition in the brain in patients with a clinical diagnosis of AD and other dementias and subjects without dementia.<sup id="cite_ref-Sabri_19-0" class="reference"><a href="#cite_note-Sabri-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>Florbetaben PET imaging showed strong tracer accumulation in the anatomically matched brain regions confirmed to have β-amyloid plaques by postmortem histopathology, thus providing direct target validation for florbetaben. Evaluation of whole brain florbetaben PET images using the clinically applicable visual assessment method demonstrated that florbetaben provides good diagnostic efficacy in detecting/excluding cerebral neuritic β-amyloid plaques. Sensitivity and specificity of the whole brain assessment was 98 and 89%, respectively, against the histopathological standard of truth. Good agreement between blinded readers (kappa 0.90) was reported. Furthermore, high negative and positive predictive values were reported for florbetaben imaging to exclude or detect β-amyloid plaques (negative predictive value 96.0% and positive predictive value 93.9%, see <sup id="cite_ref-Sabri_19-1" class="reference"><a href="#cite_note-Sabri-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup>). Intravenous injections of florbetaben are generally well tolerated in all subject groups. Analysis of 872 patients with 978 florbetaben administrations found no serious adverse reactions related to the tracer.<sup id="cite_ref-Neuraceq_FDA_label_2-2" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> All adverse reactions reported were mild to moderate in severity and temporary only. The most common reactions (incidence < 1%) were injection-site pain (3.9% of patients), injection-site erythema (1.7%) and injection-site irritation (1.2%).<sup id="cite_ref-Neuraceq_FDA_label_2-3" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> There was no overall difference in the tolerability of florbetaben between different age populations.<sup id="cite_ref-Neuraceq_FDA_label_2-4" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Repeated annual florbetaben injections showed no differences in the tolerability profile.<sup id="cite_ref-EU_4-1" class="reference"><a href="#cite_note-EU-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Risks and side effects are addressed in the patient information leaflet.<sup id="cite_ref-Neuraceq_FDA_label_2-5" class="reference"><a href="#cite_note-Neuraceq_FDA_label-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EU_4-2" class="reference"><a href="#cite_note-EU-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> You may also ask your doctor or pharmacist for further information. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Florbetaben_(18F)&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output 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"Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study". <i>Journal of Neurology, Neurosurgery, and Psychiatry</i>. <b>86</b> (4): 431–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fjnnp-2014-308094">10.1136/jnnp-2014-308094</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24970906">24970906</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25668886">25668886</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Neurology%2C+Neurosurgery%2C+and+Psychiatry&rft.atitle=A%CE%B2+imaging+with+18F-florbetaben+in+prodromal+Alzheimer%27s+disease%3A+a+prospective+outcome+study&rft.volume=86&rft.issue=4&rft.pages=431-6&rft.date=2015-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25668886%23id-name%3DS2CID&rft_id=info%3Apmid%2F24970906&rft_id=info%3Adoi%2F10.1136%2Fjnnp-2014-308094&rft.aulast=Ong&rft.aufirst=KT&rft.au=Villemagne%2C+VL&rft.au=Bahar-Fuchs%2C+A&rft.au=Lamb%2C+F&rft.au=Langdon%2C+N&rft.au=Catafau%2C+AM&rft.au=Stephens%2C+AW&rft.au=Seibyl%2C+J&rft.au=Dinkelborg%2C+LM&rft.au=Reininger%2C+CB&rft.au=Putz%2C+B&rft.au=Rohde%2C+B&rft.au=Masters%2C+CL&rft.au=Rowe%2C+CC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlorbetaben+%2818F%29" class="Z3988"></span></span> </li> <li id="cite_note-Sabri-19"><span class="mw-cite-backlink">^ <a href="#cite_ref-Sabri_19-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Sabri_19-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSabriSabbaghSeibylBarthel2015" class="citation journal cs1">Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, et al. (August 2015). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jalz.2015.02.004">"Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study"</a>. <i>Alzheimer's & Dementia</i>. <b>11</b> (8): 964–74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jalz.2015.02.004">10.1016/j.jalz.2015.02.004</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25824567">25824567</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Florbetaben+PET+imaging+to+detect+amyloid+beta+plaques+in+Alzheimer%27s+disease%3A+phase+3+study&rft.volume=11&rft.issue=8&rft.pages=964-74&rft.date=2015-08&rft_id=info%3Adoi%2F10.1016%2Fj.jalz.2015.02.004&rft_id=info%3Apmid%2F25824567&rft.aulast=Sabri&rft.aufirst=O&rft.au=Sabbagh%2C+MN&rft.au=Seibyl%2C+J&rft.au=Barthel%2C+H&rft.au=Akatsu%2C+H&rft.au=Ouchi%2C+Y&rft.au=Senda%2C+K&rft.au=Murayama%2C+S&rft.au=Ishii%2C+K&rft.au=Takao%2C+M&rft.au=Beach%2C+TG&rft.au=Rowe%2C+CC&rft.au=Leverenz%2C+JB&rft.au=Ghetti%2C+B&rft.au=Ironside%2C+JW&rft.au=Catafau%2C+AM&rft.au=Stephens%2C+AW&rft.au=Mueller%2C+A&rft.au=Koglin%2C+N&rft.au=Hoffmann%2C+A&rft.au=Roth%2C+K&rft.au=Reininger%2C+C&rft.au=Schulz-Schaeffer%2C+WJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.jalz.2015.02.004&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlorbetaben+%2818F%29" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Florbetaben_(18F)&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSabriSeibylRoweBarthel2015" class="citation journal cs1">Sabri O, Seibyl J, Rowe C, Barthel H (2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339690">"Beta-amyloid imaging with florbetaben"</a>. <i>Clinical and Translational Imaging</i>. <b>3</b> (1): 13–26. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40336-015-0102-6">10.1007/s40336-015-0102-6</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339690">4339690</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25741488">25741488</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+and+Translational+Imaging&rft.atitle=Beta-amyloid+imaging+with+florbetaben&rft.volume=3&rft.issue=1&rft.pages=13-26&rft.date=2015&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4339690%23id-name%3DPMC&rft_id=info%3Apmid%2F25741488&rft_id=info%3Adoi%2F10.1007%2Fs40336-015-0102-6&rft.aulast=Sabri&rft.aufirst=O&rft.au=Seibyl%2C+J&rft.au=Rowe%2C+C&rft.au=Barthel%2C+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4339690&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFlorbetaben+%2818F%29" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSyedDeeks2015" class="citation journal cs1">Syed YY, Deeks E (July 2015). "[(18)F]Florbetaben: a review in β-amyloid PET imaging in cognitive impairment". <i>CNS Drugs</i>. <b>29</b> (7): 605–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40263-015-0258-7">10.1007/s40263-015-0258-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26175116">26175116</a>.</cite><span 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class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_exametazime" title="Technetium (99mTc) exametazime">Exametazime</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a> (<a href="/wiki/Ioflupane_(123I)" title="Ioflupane (123I)">Ioflupane (123I)</a></li> <li><a href="/wiki/Iofetamine_(123I)" title="Iofetamine (123I)">Iofetamine (123I)</a></li> <li><a href="/wiki/Iolopride_(123I)" class="mw-redirect" title="Iolopride (123I)">Iolopride (123I)</a></li> <li><a href="/wiki/Iomazenil_(123I)" class="mw-redirect" title="Iomazenil (123I)">Iomazenil</a>)</li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> (<a href="/wiki/Florbetapir_(18F)" title="Florbetapir (18F)">Florbetapir (18F)</a>, <a href="/wiki/Flutemetamol_(18F)" title="Flutemetamol (18F)">Flutemetamol (18F)</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Skeletal_system" class="mw-redirect" title="Skeletal system">Skeletal system</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_medronic_acid" title="Technetium (99mTc) medronic acid">Medronic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Renal" class="mw-redirect" title="Renal">Renal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a> (<a href="/wiki/Sodium_iodohippurate" class="mw-redirect" title="Sodium iodohippurate">Sodium iodohippurate</a>)</li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a> <ul><li><a href="/wiki/ETS2" title="ETS2">ETS2</a></li></ul></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_mertiatide" title="Technetium (99mTc) mertiatide">Mertiatide</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gastrointestinal" class="mw-redirect" title="Gastrointestinal">Gastrointestinal</a>/<a href="/wiki/Hepatic" class="mw-redirect" title="Hepatic">Hepatic</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75"><sup>75</sup>Se</a> (<a href="/wiki/SeHCAT" title="SeHCAT">SeHCAT</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Respiratory_system" title="Respiratory system">Respiratory system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133"><sup>133</sup>Xe</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m"><sup>81m</sup>Kr</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_albumin_aggregated" title="Technetium (99mTc) albumin aggregated"><sup>99m</sup>Tc-MAA</a>, <a href="/wiki/Technetium_(99mTc)_pentetic_acid" title="Technetium (99mTc) pentetic acid">Pentetic acid</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Circulatory_system" title="Circulatory system">Cardiovascular system</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_sestamibi" title="Technetium (99mTc) sestamibi">Sestamibi</a></li> <li><a href="/wiki/Technetium_(99mTc)_tetrofosmin" title="Technetium (99mTc) tetrofosmin">Tetrofosmin</a>)</li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a> (<a href="/wiki/Indium_(111In)_imciromab" title="Indium (111In) imciromab">Imciromab</a>)</li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82"><sup>82</sup>Rb</a> (<a href="/wiki/Rubidium-82_chloride" title="Rubidium-82 chloride">Rubidium chloride</a>)</li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a> (<a href="/wiki/Iodine_(125I)_human_albumin" title="Iodine (125I) human albumin">Iodinated human albumin</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Inflammation" title="Inflammation">Inflammation</a>/<a href="/wiki/Infection" title="Infection">infection</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> (<a href="/wiki/Technetium_(99mTc)_exametazime" title="Technetium (99mTc) exametazime">Exametazime</a></li> <li><a href="/wiki/Technetium_(99mTc)_sulesomab" title="Technetium (99mTc) sulesomab">Sulesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_tilmanocept" title="Technetium (99mTc) tilmanocept">Tilmanocept</a>)</li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67"><sup>67</sup>Ga</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor" class="mw-redirect" title="Tumor">Tumor</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a> <ul><li><a href="/wiki/Technetium_(99mTc)_arcitumomab" title="Technetium (99mTc) arcitumomab">Arcitumomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_votumumab" title="Technetium (99mTc) votumumab">Votumumab</a></li> <li><a href="/wiki/Technetium_(99mTc)_hynic-octreotide" class="mw-redirect" title="Technetium (99mTc) hynic-octreotide">Hynic-octreotide</a></li></ul></li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a> <ul><li><a href="/wiki/Indium_(111In)_capromab_pendetide" title="Indium (111In) capromab pendetide">Capromab pendetide</a></li> <li><a href="/wiki/Indium_(111In)_satumomab_pendetide" title="Indium (111In) satumomab pendetide">Satumomab pendetide</a></li></ul></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a><span class="nowrap"> </span>(<a href="/wiki/Iodine_(125I)_minretumomab" class="mw-redirect" title="Iodine (125I) minretumomab">Minretumomab</a>)</li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a><span class="nowrap"> </span>(<a href="/wiki/Iobenguane" title="Iobenguane">Iobenguane (123I)</a>)</li> <li><a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a><span class="nowrap"> </span>(<a href="/wiki/Iobenguane" title="Iobenguane">Iobenguane (131I)</a>)</li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> <ul><li><a href="/wiki/Fluciclovine_(18F)" title="Fluciclovine (18F)">Fluciclovine</a></li> <li><a href="/wiki/Fluorodeoxyglucose_(18F)" title="Fluorodeoxyglucose (18F)">Fluorodeoxyglucose</a></li> <li><a href="/wiki/Fluoroethyl-L-tyrosine_(18F)" title="Fluoroethyl-L-tyrosine (18F)">Fluoroethyltyrosine</a></li> <li><a href="/wiki/Sodium_fluoride" title="Sodium fluoride">Sodium fluoride</a></li></ul></li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a> <ul><li><a href="/wiki/Copper_(64Cu)_oxodotreotide" title="Copper (64Cu) oxodotreotide">Dotatate</a></li></ul></li> <li><a href="/wiki/Piflufolastat_F-18" title="Piflufolastat F-18">Piflufolastat F-18</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adrenal_cortex" title="Adrenal cortex">Adrenal cortex</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a> / <a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a> (<a href="/wiki/19-Iodocholesterol" class="mw-redirect" title="19-Iodocholesterol">Iodocholesterol</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Radionuclide" title="Radionuclide">Radionuclides</a><br />(including <a href="/wiki/Radioactive_tracer" title="Radioactive tracer">tracers</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Positron" title="Positron">positron</a> (<a href="/wiki/PET_radiotracer" title="PET radiotracer">PET</a> <a href="/wiki/List_of_PET_radiotracers" title="List of PET radiotracers">list</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbon-11" class="mw-redirect" title="Carbon-11"><sup>11</sup>C</a> (<a href="/wiki/11C_ME@HAPTHI" title="11C ME@HAPTHI">[<sup>11</sup>C]ME@HAPTHI</a>)</li> <li><a href="/wiki/25B-NBOMe" title="25B-NBOMe">25B-NBOMe</a> (Cimbi-36)</li> <li><a href="/wiki/Acetate" title="Acetate">Acetate</a></li> <li><a href="/wiki/Carbon-11-choline" title="Carbon-11-choline">Choline</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/DASB" title="DASB">DASB</a></li> <li><a href="/wiki/DTBZ" class="mw-redirect" title="DTBZ">DTBZ</a></li> <li><a href="/wiki/Flumazenil" title="Flumazenil">Flumazenil</a></li> <li><a href="/wiki/Methionine" title="Methionine">Methionine</a></li> <li><a href="/wiki/N-Methylspiperone" title="N-Methylspiperone">N-Methylspiperone</a></li> <li><a href="/wiki/Pittsburgh_compound_B" title="Pittsburgh compound B">Pittsburgh compound B</a></li> <li><a href="/wiki/Raclopride" title="Raclopride">Raclopride</a></li> <li><a href="/wiki/Verapamil" title="Verapamil">Verapamil</a>)</li> <li><a href="/wiki/Nitrogen-13" title="Nitrogen-13"><sup>13</sup>N</a> <ul><li><a href="/wiki/Ammonia_(13N)" title="Ammonia (13N)">Ammonia</a></li></ul></li> <li><a href="/wiki/Copper-64" title="Copper-64"><sup>64</sup>Cu</a></li> <li><a href="/wiki/Desmethoxyfallypride" title="Desmethoxyfallypride">Desmethoxyfallypride</a></li> <li><a href="/wiki/Fallypride" title="Fallypride">Fallypride</a></li> <li><a class="mw-selflink selflink">Florbetaben (18F)</a></li> <li><a href="/wiki/Florbetapir_(18F)" title="Florbetapir (18F)">Florbetapir (18F)</a></li> <li><a href="/wiki/Flortaucipir_(18F)" title="Flortaucipir (18F)">Flortaucipir (18F)</a></li> <li><a href="/wiki/Flotufolastat_F-18" title="Flotufolastat F-18">Flotufolastat F-18</a></li> <li><a href="/w/index.php?title=Flubatine&action=edit&redlink=1" class="new" title="Flubatine (page does not exist)">Flubatine</a></li> <li><a href="/wiki/Fluciclovine" class="mw-redirect" title="Fluciclovine">Fluciclovine</a></li> <li><a href="/wiki/Fludeoxyglucose_(18F)" class="mw-redirect" title="Fludeoxyglucose (18F)">Fludeoxyglucose (18F)</a> (FDG)-<a href="/wiki/Glucose" title="Glucose">glucose</a> analogue</li> <li><a href="/wiki/Flumazenil" title="Flumazenil">Flumazenil</a></li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18"><sup>18</sup>F</a> (<a href="/wiki/Altanserin" title="Altanserin">Altanserin</a>)</li> <li><a href="/wiki/Fluorocholine" title="Fluorocholine">Fluorocholine</a></li> <li><a href="/w/index.php?title=Fluorodeoxysorbitol&action=edit&redlink=1" class="new" title="Fluorodeoxysorbitol (page does not exist)">Fluorodeoxysorbitol</a> (FDS)</li> <li><a href="/wiki/Fluorodopa" title="Fluorodopa">Fluorodopa</a></li> <li><a href="/wiki/Fluoroestradiol_F-18" title="Fluoroestradiol F-18">Fluoroestradiol F-18</a></li> <li><a href="/wiki/Fluorothymidine_F-18" title="Fluorothymidine F-18">Fluorothymidine F-18</a></li> <li><a href="/wiki/Flurpiridaz_(18F)" title="Flurpiridaz (18F)">Flurpiridaz (18F)</a></li> <li><a href="/w/index.php?title=Fluspidine&action=edit&redlink=1" class="new" title="Fluspidine (page does not exist)">Fluspidine</a></li> <li><a href="/wiki/Flutemetamol" class="mw-redirect" title="Flutemetamol">Flutemetamol</a></li> <li><a href="/wiki/FMISO" title="FMISO">FMISO</a></li> <li><a href="/wiki/Gallium_(68Ga)_gozetotide" title="Gallium (68Ga) gozetotide">Gallium (<sup>68</sup>Ga) gozetotide</a></li> <li><a href="/wiki/Gallium-68" class="mw-redirect" title="Gallium-68"><sup>68</sup>Ga</a></li> <li><a href="/wiki/Mefway" class="mw-redirect" title="Mefway">Mefway</a></li> <li><a href="/wiki/MPPF" title="MPPF">MPPF</a></li> <li><a href="/wiki/N-Methylspiperone" title="N-Methylspiperone">N-Methylspiperone</a></li> <li><a href="/wiki/Nifene" title="Nifene">Nifene</a></li> <li><a href="/wiki/O-(2-fluorethyl)-L-thyrosine" class="mw-redirect" title="O-(2-fluorethyl)-L-thyrosine">FET</a></li> <li><a href="/wiki/Oxygen-15" class="mw-redirect" title="Oxygen-15"><sup>15</sup>O</a> (<a href="/wiki/Water" title="Water">Water</a>)</li> <li><a href="/wiki/Piflufolastat_F-18" title="Piflufolastat F-18">Piflufolastat F-18</a></li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82"><sup>82</sup>Rb</a> (<a href="/wiki/Rubidium-82_chloride" title="Rubidium-82 chloride">Rubidium chloride</a>)</li> <li><a href="/wiki/Setoperone" title="Setoperone">Setoperone</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Gamma_ray" title="Gamma ray">gamma ray</a>/<a href="/wiki/Photon" title="Photon">photon</a> (<a href="/wiki/Single-photon_emission_computed_tomography" title="Single-photon emission computed tomography">SPECT</a>/<a href="/wiki/Scintigraphy" title="Scintigraphy">scintigraphy</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chromium-51" class="mw-redirect" title="Chromium-51"><sup>51</sup>Cr</a></li> <li><a href="/wiki/Cobalt-57" class="mw-redirect" title="Cobalt-57"><sup>57</sup>Co</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67"><sup>67</sup>Ga</a></li> <li><a href="/wiki/Indium-111" title="Indium-111"><sup>111</sup>In</a></li> <li><a href="/wiki/Iodine-123" title="Iodine-123"><sup>123</sup>I</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125"><sup>125</sup>I</a></li> <li><a href="/wiki/Iodine-131" title="Iodine-131"><sup>131</sup>I</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m"><sup>81m</sup>Kr</a></li> <li><a href="/wiki/Samarium-153" class="mw-redirect" title="Samarium-153"><sup>153</sup>Sm</a></li> <li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75"><sup>75</sup>Se</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m"><sup>99m</sup>Tc</a></li> <li><a href="/wiki/Thallium-201" class="mw-redirect" title="Thallium-201"><sup>201</sup>Tl</a></li> <li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133"><sup>133</sup>Xe</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>Isotopes used: <div class="hlist"> <ul><li><a href="/wiki/Carbon-11" class="mw-redirect" title="Carbon-11">carbon-11</a></li> <li><a href="/wiki/Chromium-51" class="mw-redirect" title="Chromium-51">chromium-51</a></li> <li><a href="/wiki/Cobalt-57" class="mw-redirect" title="Cobalt-57">cobalt-57</a></li> <li><a href="/wiki/Copper-64" title="Copper-64">copper-64</a></li> <li><a href="/wiki/Fluorine-18" title="Fluorine-18">fluorine-18</a></li> <li><a href="/wiki/Gallium-67" class="mw-redirect" title="Gallium-67">gallium-67</a></li> <li><a href="/wiki/Gallium-68" class="mw-redirect" title="Gallium-68">gallium-68</a></li> <li><a href="/wiki/Indium-111" title="Indium-111">indium-111</a></li> <li><a href="/wiki/Iodine-123" title="Iodine-123">iodine-123</a></li> <li><a href="/wiki/Iodine-125" title="Iodine-125">iodine-125</a></li> <li><a href="/wiki/Iodine-131" title="Iodine-131">iodine-131</a></li> <li><a href="/wiki/Krypton-81m" class="mw-redirect" title="Krypton-81m">krypton-81m</a></li> <li><a href="/wiki/Nitrogen-13" title="Nitrogen-13">nitrogen-13</a></li> <li><a href="/wiki/Oxygen-15" class="mw-redirect" title="Oxygen-15">oxygen-15</a></li> <li><a href="/wiki/Rubidium-82" title="Rubidium-82">rubidium-82</a></li> <li><a href="/wiki/Samarium-153" class="mw-redirect" title="Samarium-153">samarium-153</a></li> <li><a href="/wiki/Selenium-75" class="mw-redirect" title="Selenium-75">selenium-75</a></li> <li><a href="/wiki/Technetium-99m" title="Technetium-99m">technetium-99m</a></li> <li><a href="/wiki/Thallium-201" class="mw-redirect" title="Thallium-201">thallium-201</a></li> <li><a href="/wiki/Xenon-133" class="mw-redirect" title="Xenon-133">xenon-133</a></li></ul> </div><div class="hlist">See also: <a href="/wiki/ATC_code_V10" title="ATC code V10">Therapeutic radiopharmaceuticals (V10)</a> </div></div></td></tr></tbody></table></div> 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