Menstrual Cycle Irregularity and Risk for Future Cardiovascular Disease | The Journal of Clinical Endocrinology & Metabolism

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Solomon</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Caren G. Solomon <span class="info-card-footnote"><span class="xrefLink" id="jumplink-cor1"></span><a href="javascript:;" reveal-id="cor1" data-open="cor1" class="link link-ref link-reveal xref-default"></a></span> </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Division of Women’s Health (C.G.S., A.D.), Boston, Massachusetts 02115</div><div class="aff"><span class="label title-label">2</span>Division of General Medicine (C.G.S.), Boston, Massachusetts 02115</div> </div> <div class="info-author-correspondence"> <div content-id="cor1"><span class="label title-label">*</span>Address all correspondence and requests for reprints to: Dr. Caren G. 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href="javascript:;" class="microsite-search-icon navbar-search-submit icon-menu_search"> <span class="screenreader-text">Search</span> </a> </div> </div> <div class="navbar-search-advanced"><a href="/jcem/advanced-search" class="advanced-search js-advanced-search">Advanced Search</a></div> </div> <div class="navbar-search-collapsed"><a href="javascript:;" class="icon-menu_search js_expand-navsearch"><span class="screenreader-text">Search Menu</span></a></div> </div> </div> <input id="routename" name="RouteName" type="hidden" value="jcem" /> </div> </div> </div> </div> <div id="ContentTab" class="content active"> <div class="widget widget-ArticleFulltext widget-instance-OUP_Abstract_Article_FullText_Widget"> <div class="module-widget"> <div class="widget-items" data-widgetname="ArticleFulltext"> <h2 scrollto-destination=53395376 id="53395376" class="abstract-title js-splitscreen-abstract-title" ></h2> <section class="abstract"><p class="chapter-para">Cross-sectional studies suggest that women who have irregular menstrual cycles and hyperandrogenism may be at increased risk for cardiovascular disease (CVD). However, prospective data are lacking on the relationship between menstrual cycle irregularity and subsequent CVD risk. The objective of this study was to assess prospectively the risk for coronary heart disease (CHD) and stroke associated with a history of irregular menstrual cycles. The study design was a prospective cohort study of 82,439 female nurses who provided information in 1982 on prior menstrual regularity (at ages 20–35 yr) and were followed through 1996 for cardiovascular events. Incident reports of nonfatal myocardial infarction, fatal CHD, and nonfatal and fatal stroke were made. Medical records were reviewed for confirmation.</p><p class="chapter-para">During 14 yr (1,155,915 person-yr) of follow-up, there were 1417 incident cases of CHD and 838 incident cases of stroke, including 471 cases of ischemic stroke. Compared with women reporting a history of very regular menstrual cycles, women reporting usually irregular or very irregular cycles had an increased risk for nonfatal or fatal CHD [age-adjusted relative risks (RR), 1.25 and 1.67, respectively; 95% confidence intervals (CI), 1.07–1.47 and 1.35–2.06, respectively]. Increased risks for CHD associated with prior cycle irregularity remained significant after adjustment for body mass index and several potential confounders. There was a nonsignificant increase in overall stroke risk (RR, 1.30; 95% CI = 0.97–1.74) and in ischemic stroke risk (RR, 1.40; 95% CI = 0.97–2.04) associated with very irregular cycles.</p><p class="chapter-para">Menstrual cycle irregularity may be a marker of metabolic abnormalities predisposing to increased risk for CVD.</p></section> <div class="article-metadata-panel clearfix at-ArticleMetadata"></div>  <div class="widget widget-ArticlePubStateInfo widget-instance-OUP_ArticlePubStateInfo"> </div> <div class="article-metadata-standalone-panel clearfix"></div> <div class="copyright copyright-statement">Copyright © 2002 by The Endocrine Society</div> <span id="UserHasAccess" data-userHasAccess="False"></span> </div> </div> </div> <div class="widget widget-SolrResourceMetadata widget-instance-OUP_Article_ResourceMetadata_Widget"> <div class="article-metadata-panel solr-resource-metadata js-metadata-panel at-ContentMetadata"> <div class="article-metadata-tocSections"> <div 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<td>102</td> </tr> <tr> <td>November 2022</td> <td>107</td> </tr> <tr> <td>December 2022</td> <td>95</td> </tr> <tr> <td>January 2023</td> <td>81</td> </tr> <tr> <td>February 2023</td> <td>58</td> </tr> <tr> <td>March 2023</td> <td>102</td> </tr> <tr> <td>April 2023</td> <td>76</td> </tr> <tr> <td>May 2023</td> <td>75</td> </tr> <tr> <td>June 2023</td> <td>59</td> </tr> <tr> <td>July 2023</td> <td>64</td> </tr> <tr> <td>August 2023</td> <td>72</td> </tr> <tr> <td>September 2023</td> <td>77</td> </tr> <tr> <td>October 2023</td> <td>88</td> </tr> <tr> <td>November 2023</td> <td>100</td> </tr> <tr> <td>December 2023</td> <td>74</td> </tr> <tr> <td>January 2024</td> <td>97</td> </tr> <tr> <td>February 2024</td> <td>107</td> </tr> <tr> <td>March 2024</td> <td>68</td> </tr> <tr> <td>April 2024</td> <td>86</td> </tr> <tr> <td>May 2024</td> <td>69</td> </tr> <tr> <td>June 2024</td> <td>85</td> </tr> <tr> <td>July 2024</td> <td>81</td> </tr> <tr> <td>August 2024</td> <td>77</td> </tr> <tr> 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Menstrual Cycle Irregularity and Risk for Future Cardiovascular Disease | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic