Thermosensitive Hydrogel Development for Its Possible Application in Cardiac Cell Therapy

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Development for Its Possible Application in Cardiac Cell Therapy</title> <meta name="description" content="Thermosensitive Hydrogel Development for Its Possible Application in Cardiac Cell Therapy"> <meta name="keywords" content="cardiac cell therapy, cardiac ischemia, natural polymers, thermosensitive hydrogel"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Thermosensitive Hydrogel Development for Its Possible Application in Cardiac Cell Therapy"> <meta name="citation_author" content="Lina Paola Orozco-Marín"> <meta name="citation_author" content="Yuliet Montoya"> <meta name="citation_author" content="John Bustamante"> <meta name="citation_publication_date" content="2021/12/14"> <meta name="citation_journal_title" content="International Journal of Biomedical and Biological Engineering"> <meta name="citation_volume" content="15"> <meta 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class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Lina%20Paola%20Orozco-Mar%C3%ADn">Lina Paola Orozco-Marín</a>, <a href="https://publications.waset.org/search?q=Yuliet%20Montoya"> Yuliet Montoya</a>, <a href="https://publications.waset.org/search?q=John%20Bustamante"> John Bustamante</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Ischemic events can culminate in acute myocardial infarction with irreversible cardiac lesions that cannot be restored due to the limited regenerative capacity of the heart. Tissue engineering proposes therapeutic alternatives by using biomaterials to resemble the native extracellular medium combined with healthy and functional cells. This research focused on developing a natural thermosensitive hydrogel, its physical-chemical characterization and in vitro biocompatibility determination. Hydrogels’ morphological characterization was carried out through scanning electron microscopy and its chemical characterization by employing Infrared Spectroscopy technic. In addition, the biocompatibility was determined using fetal human ventricular cardiomyocytes cell line RL-14 and the MTT cytotoxicity test according to the ISO 10993-5 standard. Four biocompatible and thermosensitive hydrogels were obtained with a three-dimensional internal structure and two gelation times. The results show the potential of the hydrogel to increase the cell survival rate to the cardiac cell therapies under investigation and lay the foundations to continue with its characterization and biological evaluation both in vitro and in vivo models.</p> <iframe src="https://publications.waset.org/10012340.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=cardiac%20cell%20therapy" title="cardiac cell therapy">cardiac cell therapy</a>, <a href="https://publications.waset.org/search?q=cardiac%20ischemia" title=" cardiac ischemia"> cardiac ischemia</a>, <a href="https://publications.waset.org/search?q=natural%20polymers" title=" natural polymers"> natural polymers</a>, <a href="https://publications.waset.org/search?q=thermosensitive%20hydrogel" title=" thermosensitive hydrogel"> thermosensitive hydrogel</a> </p> <a href="https://publications.waset.org/10012340/thermosensitive-hydrogel-development-for-its-possible-application-in-cardiac-cell-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10012340/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10012340/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10012340/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10012340/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10012340/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10012340/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10012340/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10012340/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10012340/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10012340/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10012340.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">755</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] WHO, “World Healt Organization (WHO),” 2017. <br>[Online]. Available: https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). <br>[2] L. A. Lara-Martínez, I. Gutiérrez-Villegas, V. M. Arenas-Luna, and S. Hernández-Gutierrez, “Células madre: buscando marcadores de superficie celular que predispongan compromiso de diferenciación cardiaca,” Arch. Cardiol. México, vol. 88, no. 5, pp. 483–495, 2018. <br>[3] D. V. Gutiérrez Triana and P. Caro, “proceso de participacion para la promoción de la salud y la prevención de la enfermedad: La experiencia de la Dirección de Promoción y Prevención.,” Bogotá D.C, 2016. <br>[4] R. Sun, X. Li, M. Liu, Y. Zeng, S. Chen, and P. Zhang, “Advances in stem cell therapy for cardiovascular disease (Review),” Int. J. Mol. Med., vol. 38, no. 1, pp. 23–29, 2016. <br>[5] T. Eschenhagen et al., “Cardi<br>[omyocyte Regeneration: A Consensus Statement,” Circulation, vol. 136, no. 7, pp. 680–686, 2017. <br>[6] X. Tang et al., Polymeric Biomaterials in Tissue Engineering and Regenerative Medicine. 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Eng., vol. 20, pp. 21–47, 2018. </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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Thermosensitive Hydrogel Development for Its Possible Application in Cardiac Cell Therapy