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<!DOCTYPE html> <html> <head> <meta charset="utf-8"> <title>KEGG MODULE: M00095</title> <link rel="stylesheet" href="/css/kegg.css" type="text/css"> <style type="text/css"> body { padding: 10px; } td { font-size:12px; font-family:verdana,arial,helvetica,sans-serif; vertical-align: top; } .definition { margin-left: 10px; margin-top: 5px; margin-bottom: 0px; } .definition table tr td { padding-right: 10px; } div.error { margin-top: 0px; margin-bottom: 20px; } </style> <script src="/js/jquery-3.1.0.min.js"></script> <script src="/js/jquery.balloon.min.js"></script> <script src="/js/kegg-timer-manager.js"></script> <script src="/js/kegg-simple-popup.js"></script> <script src="/js/kegg-mouse-capture.js"></script> <script language="javascript" type="text/javascript">  </script> </head> <body> <table border="0" cellspacing="0" cellpadding="0" width="100%" > <tr> <td style="width:80px;"> <a href="/kegg/module.html"><img align="middle" border="0" src="/Fig/bget/kegg3.gif" alt="KEGG"></a> </td> <td style="vertical-align:middle;"> <a name="module:M00095"></a><font class="title3"><b>C5 isoprenoid biosynthesis, mevalonate pathway</b></font> </td>  </tr> </table> [ <a href="/brite/htext=ko00002a.keg&query=M00095&option=-a&node_proc=ko00002a_org&proc_enabled=mpl&panel=collapse">Module menu</a> | <a href="javascript:void(open_ko_list('M00095', 'mpl'))">KO/Gene/Compound list</a> | <a href="javascript:void(window.open('/kegg/document/help_module.html','KEGG_Help','width=720,height=640'))">Help</a> ] <div style="margin: 5px 0px 5px 0px;"> <input type="button" class="change-type" value="Change module type" data-entry="M00095"> </div> <div class="definition"> <table> <tr> <td>Entry</td> <td> mpl_M00095 (2 block missing) </td> </tr> <tr> <td>Name</td> <td>C5 isoprenoid biosynthesis, mevalonate pathway</td> </tr> <tr> <td>Definition</td> <td> <a href="/entry/K00626">K00626</a> <a href="/entry/K01641">K01641</a> <a href="/entry/K00021">K00021</a> <a href="/entry/K00869">K00869</a> (<a href="/entry/K00938">K00938</a>,<a href="/entry/K13273">K13273</a>) <a href="/entry/K01597">K01597</a> <a href="/entry/K01823">K01823</a><br /> <button class="btn" onclick="location.href='http://www.kegg.jp/kegg-bin/view_ortholog_table?md=M00095'">Ortholog table</button> <button class="btn" onclick="location.href='/kegg-bin/show_taxonomy?id=M00095'">Taxonomy</button>  </td> </tr> <tr> <td>Type</td> <td>Pathway module</td> </tr> <tr> <td>Organism</td> <td>Methanosphaerula palustris E1-9c</td> </tr> <tr> <td>Pathway</td> <td> <span style="margin-right:5px;"> <a href="/pathway/mpl00900+M00095">mpl00900</a> </span> <span style="margin-right:5px;"> <a href="/pathway/mpl01100+M00095">mpl01100</a> </span> <span style="margin-right:5px;"> <a href="/pathway/mpl01110+M00095">mpl01110</a> </span> </td> </tr> <tr> <td>Reaction</td> <td><a href="/entry/R00238">R00238</a> <a href="/entry/C00024">C00024</a> -> <a href="/entry/C00332">C00332</a><br><a href="/entry/R01978">R01978</a> <a href="/entry/C00332">C00332</a> + <a href="/entry/C00024">C00024</a> -> <a href="/entry/C00356">C00356</a><br><a href="/entry/R02082">R02082</a> <a href="/entry/C00356">C00356</a> -> <a href="/entry/C00418">C00418</a><br><a href="/entry/R02245">R02245</a> <a href="/entry/C00418">C00418</a> -> <a href="/entry/C01107">C01107</a><br><a href="/entry/R03245">R03245</a> <a href="/entry/C01107">C01107</a> -> <a href="/entry/C01143">C01143</a><br><a href="/entry/R01121">R01121</a> <a href="/entry/C01143">C01143</a> -> <a href="/entry/C00129">C00129</a><br><a href="/entry/R01123">R01123</a> <a href="/entry/C00129">C00129</a> -> <a href="/entry/C00235">C00235</a></td> </tr> </table> </div> <form action="/kegg-bin/show_module"> <input type="hidden" name="map" value="M00095"> <input type="hidden" name="org" value="mpl"> <div style="margin-top:0px;"> <table cellpadding="10"> <tr> <td><img src="/tmp/pathway_thumbnail/mpl_M00095.png?1740310060" usemap="#module1" border="0" alt="MODULE IMAGE"></td> <td><img src="/tmp/pathway_thumbnail/M00095_reaction.png?1740310060" usemap="#reaction1" border="0" alt="MODULE-REACTION IMAGE"></td> </tr> </table> <map name="module1"> <area shape="rect" id="node1_0" href="/entry/mpl:Mpal_2509" title="Mpal_2509" alt="" coords="55,19,129,41"/> <area shape="rect" id="node2_1" href="/entry/mpl:Mpal_2510" title="Mpal_2510" alt="" coords="55,77,129,100"/> <area shape="rect" id="node3_2" href="/entry/mpl:Mpal_2647" title="Mpal_2647" alt="" coords="55,136,129,159"/> <area shape="rect" id="node4_3" href="/entry/mpl:Mpal_2376" title="Mpal_2376" alt="" coords="55,195,129,217"/> <area shape="rect" id="node5_4" href="/entry/K00938" title="K00938 (E2.7.4.2)" alt="" coords="17,253,90,276"/> <area shape="rect" id="node5_5" href="/entry/K13273" title="K13273 (PMVK)" alt="" coords="94,253,167,276"/> <area shape="rect" id="node6_6" href="/entry/K01597" title="K01597 (MVD)" alt="" coords="55,312,129,335"/> <area shape="rect" id="node7_7" href="/entry/mpl:Mpal_2374" title="Mpal_2374" alt="" coords="55,371,129,393"/> </map> <map name="reaction1"> <area shape="poly" id="node1" href="/entry/C00024" title="C00024 (Acetyl-CoA)" alt="" coords="118,29,117,22,111,15,103,10,93,7,81,5,70,7,60,10,51,15,46,22,44,29,46,37,51,43,60,49,70,52,81,53,93,52,103,49,111,43,117,37"/> <area shape="rect" id="node2" href="/entry/R00238" title="R00238" alt="" coords="5,83,83,105"/> <area shape="rect" id="node4" href="/entry/R01978" title="R01978" alt="" coords="43,212,120,235"/> <area shape="poly" id="node3" href="/entry/C00332" title="C00332 (Acetoacetyl-CoA)" alt="" coords="81,159,79,151,74,145,66,139,55,136,44,135,33,136,22,139,14,145,9,151,7,159,9,166,14,173,22,178,33,181,44,183,55,181,66,178,74,173,79,166"/> <area shape="poly" id="node5" href="/entry/C00356" title="C00356 ((S)-3-Hydroxy-3-methylglutaryl-CoA)" alt="" coords="118,288,117,281,111,274,103,269,93,265,81,264,70,265,60,269,51,274,46,281,44,288,46,295,51,302,60,307,70,311,81,312,93,311,103,307,111,302,117,295"/> <area shape="rect" id="node6" href="/entry/R02082" title="R02082" alt="" coords="43,341,120,364"/> <area shape="poly" id="node7" href="/entry/C00418" title="C00418 ((R)-Mevalonate)" alt="" coords="118,417,117,410,111,403,103,398,93,395,81,393,70,395,60,398,51,403,46,410,44,417,46,425,51,431,60,437,70,440,81,441,93,440,103,437,111,431,117,425"/> <area shape="rect" id="node8" href="/entry/R02245" title="R02245" alt="" coords="43,471,120,493"/> <area shape="poly" id="node9" href="/entry/C01107" title="C01107 ((R)-5-Phosphomevalonate)" alt="" coords="118,547,117,539,111,533,103,527,93,524,81,523,70,524,60,527,51,533,46,539,44,547,46,554,51,561,60,566,70,569,81,571,93,569,103,566,111,561,117,554"/> <area shape="rect" id="node10" href="/entry/R03245" title="R03245" alt="" coords="43,600,120,623"/> <area shape="poly" id="node11" href="/entry/C01143" title="C01143 ((R)-5-Diphosphomevalonate)" alt="" coords="118,676,117,669,111,662,103,657,93,653,81,652,70,653,60,657,51,662,46,669,44,676,46,683,51,690,60,695,70,699,81,700,93,699,103,695,111,690,117,683"/> <area shape="rect" id="node12" href="/entry/R01121" title="R01121" alt="" coords="43,729,120,752"/> <area shape="poly" id="node13" href="/entry/C00129" title="C00129 (Isopentenyl diphosphate)" alt="" coords="118,805,117,798,111,791,103,786,93,783,81,781,70,783,60,786,51,791,46,798,44,805,46,813,51,819,60,825,70,828,81,829,93,828,103,825,111,819,117,813"/> <area shape="rect" id="node14" href="/entry/R01123" title="R01123" alt="" coords="43,859,120,881"/> <area shape="poly" id="node15" href="/entry/C00235" title="C00235 (Dimethylallyl diphosphate)" alt="" coords="118,935,117,927,111,921,103,915,93,912,81,911,70,912,60,915,51,921,46,927,44,935,46,942,51,949,60,954,70,957,81,959,93,957,103,954,111,949,117,942"/> </map> </div> </form> <form name="taxonomy1" 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