Nature Methods

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class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>With a pictorial Editorial this month, we celebrate the beauty of microscopy images.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Editorial</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-07" itemprop="datePublished">07 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41592-024-02489-y/MediaObjects/41592_2024_2489_Figa_HTML.png?as=webp 160w, 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the reconstruction and misalignment challenge in single-particle cryo-EM caused by the preferred-orientation problem. spIsoNet can also improve map isotropy and particle alignment of preferentially oriented molecules during subtomogram averaging in cryogenic electron tomography.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yun-Tao Liu</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Hongcheng Fan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Z. 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