Outstanding Aussie awarded 1.25 million to fight lung cancer

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She has a Bachelor of Science in Biology from Stanford University and a PhD in Evolutionary Biology from the University of Queensland.</p> </div> </a> <div id="author-name" class="hide"> <a href="https://cosmosmagazine.com/contributor/ariel-marcy/" class="bio"> By Ariel Marcy </a> </div> <div class="favourite__wrapper row cols"> <button class="showDialog simplefavorite-button" aria-label="Favourite button"> </button> </div> </section> </div> <div class="primary-content cols-1 col-span-5 col"> <div class="flexible-content "> <div class="copy"> <p>An Australian, Dr Clare Weeden, has been awarded a fellowship and will return to Australia to set up a lab focusing on lung cancer, particularly in non-smokers.</p> <p><a href="https://cosmosmagazine.com/health/women-lung-cancer-rates-going-up/" target="_blank" rel="noreferrer noopener">Lung cancer</a> is the leading cause of cancer-related death in Australia and about <a href="https://www.cancer.org.au/cancer-information/what-is-cancer/facts-and-figures" target="_blank" rel="noreferrer noopener">25% of lung cancers</a> occur in people who have never smoked.</p> <iframe src="https://players.brightcove.net/5483960636001/default_default/index.html?videoId=6364009564112" allowfullscreen="" allow="encrypted-media" width="960" height="540"></iframe> <p>“I am fascinated by how the air we breathe imprints upon our lung and may influence later disease,” says Weeden<em>.</em></p> <p>The type of cancer more commonly found in non-smokers is called EGFR-driven lung cancer after the epidermal growth factor receptor (EGFR). Mutations in the <em>EGFR</em> gene can predispose cells to divide more rapidly and become cancerous. Weedon and her colleagues also found that <em>EGFR</em> mutations are common in healthy lungs but are kept in check by the body. Such non-cancerous cells with these mutations are referred to as dormant.  </p> <p>In 2023, Weeden and colleagues at the Crick Institute in London <a href="https://www.nature.com/articles/s41586-023-05874-3" target="_blank" rel="noreferrer noopener">published</a> these findings in <em>Nature.</em></p> <p>The authors also looked at 33,000 cases of EGFR-driven lung cancer in three different cities across the globe and found a significant association with <a href="https://cosmosmagazine.com/health/no-safe-level-of-air-pollution-says-us-study/" target="_blank" rel="noreferrer noopener">air pollution</a>.</p> <div class="advert ad-in-content ad-mobile auh-250"><div id="adn-00000000001fc2ca-i0p0" style="display: none"></div></div> <p>But unlike the chemicals <a href="https://cosmosmagazine.com/health/body-and-mind/debunks-podcast-vaping/" target="_blank" rel="noreferrer noopener">found in cigarettes</a>, which directly damage DNA, air pollution appears to cause cancer in a different way.</p> <a href="https://link.cosmosmagazine.com/OP59" class="newsletter-cta" data-device="mobile"> <img decoding="async" src="data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCAzMDAgMjUwIiB3aWR0aD0iMzAwIiBoZWlnaHQ9IjI1MCIgZGF0YS11PSIlMkZ3cC1jb250ZW50JTJGdXBsb2FkcyUyRjIwMjQlMkYwMyUyRldlZWtseS1DYXRjaHVwLTMwMHgyNTAtMS5wbmciIGRhdGEtdz0iMzAwIiBkYXRhLWg9IjI1MCIgZGF0YS1iaXA9IiI+PC9zdmc+" data-spai="1" alt="Newsletter" title="outstanding aussie awarded 1.25 million to fight lung cancer 1"><noscript data-spai="1"><img decoding="async" src="https://cdn.shortpixel.ai/spai/q_lossy+ret_img+to_auto/cosmosmagazine.com/wp-content/uploads/2024/03/Weekly-Catchup-300x250-1.png" data-spai-egr="1" alt="Newsletter" title="outstanding aussie awarded 1.25 million to fight lung cancer 1"></noscript> </a> <div class="in-content-area related-box-wrapper content-third content-right margin-bottom-1"> <div class="gradient-title">Read More</div> <ul class="related-box article-listing"> <li class="cols"> <div class="article article-post"> <a href="https://cosmosmagazine.com/health/women-lung-cancer-rates-going-up/" class="thumbnail ar-16-9" aria-label="Article link"> <span data-spai-bg-on="1" class="image" style="background-image: url(data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCAxMjAwIDY3NSIgd2lkdGg9IjEyMDAiIGhlaWdodD0iNjc1IiBkYXRhLXU9Imh0dHBzJTNBJTJGJTJGY29zbW9zbWFnYXppbmUuY29tJTJGd3AtY29udGVudCUyRnVwbG9hZHMlMkYyMDIzJTJGMDIlMkZsdW5ncy1zbW9rZS5qcGciIGRhdGEtdz0iMTIwMCIgZGF0YS1oPSI2NzUiIGRhdGEtYmlwPSIiPjwvc3ZnPg==)"></span> </a> <div class="article-content has-very-light-grey-background-color"> <a href="/health/"> <span class="category health-color"> Health </span> </a> <a href="https://cosmosmagazine.com/health/women-lung-cancer-rates-going-up/"> <h3>Lung cancer death rates are going up among women, and down among men. The reason has everything to do with tobacco take-up</h3> </a> </div> </div> </li> </ul> </div> <p>“We discovered that air pollution triggers an inflammatory response from lung macrophages [white blood cells], which in turn ‘awakens’ these previously dormant cells to form lung cancers,” Weeden told <em>Cosmos</em>.</p> <p>Now, Clare has been brought back to Australia with a $1.25 million <a href="https://www.cslfellowships.com.au/about" target="_blank" rel="noreferrer noopener">CSL Centenary Fellowship</a>, which identifies rising medical researchers each year. The award is granted over five years to help recipients establish a medical research lab in Australia.</p> <p>Weeden will establish her lab at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne where she will continue to pursue early detection and intervention of lung cancer.</p> <p>“Now that we know a little bit about one mechanism by which these cancers form, we could identify signals of these early stages to stratify at-risk patients, and in the future, therapies to curtail the outgrowth of these cells into tumours.”</p> <div class="advert ad-in-content ad-mobile auh-250"><div id="adn-00000000001fc2ca-i1p0" style="display: none"></div></div> <p>These interventions will become increasingly important as 99% of the world’s population is exposed to air pollution above The World Health Organization’s safety guidelines.</p> <p>“The nature of the challenges our lung cells face is also changing,” says Weeden. “A hundred years ago, our cities suffered from pollution from burning coal… Today, with climate change, our lungs face new challenges from, for example, bushfire smoke. 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Outstanding Aussie awarded 1.25 million to fight lung cancer