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class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav 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class="firstHeading mw-first-heading"><span class="mw-page-title-main">CCL5</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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href="https://bs.wikipedia.org/wiki/CCL5" title="CCL5 – Bosnian" lang="bs" hreflang="bs" data-title="CCL5" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/CCL5" title="CCL5 – Welsh" lang="cy" hreflang="cy" data-title="CCL5" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/CCL5" title="CCL5 – German" lang="de" hreflang="de" data-title="CCL5" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/CCL5" title="CCL5 – Indonesian" lang="id" hreflang="id" data-title="CCL5" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/CCL5" title="CCL5 – Japanese" lang="ja" hreflang="ja" data-title="CCL5" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/CCL5" title="CCL5 – Polish" lang="pl" hreflang="pl" data-title="CCL5" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/CCL5" title="CCL5 – Portuguese" lang="pt" hreflang="pt" data-title="CCL5" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/CCL5" title="CCL5 – Serbian" lang="sr" hreflang="sr" data-title="CCL5" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/CCL5" title="CCL5 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="CCL5" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/CCL5" title="CCL5 – Tatar" lang="tt" hreflang="tt" data-title="CCL5" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" 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class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CCL5</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:PDB_1eqt_EBI.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/250px-PDB_1eqt_EBI.jpg" decoding="async" width="250" height="188" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/375px-PDB_1eqt_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/500px-PDB_1eqt_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P30882%20or%20P13501">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P30882,P13501">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1B3A">1B3A</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EQT">1EQT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1HRJ">1HRJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RTN">1RTN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RTO">1RTO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1U4L">1U4L</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1U4M">1U4M</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1U4P">1U4P</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1U4R">1U4R</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2L9H">2L9H</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2VXW">2VXW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5CMD">5CMD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5DNF">5DNF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5COY">5COY</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/10632">CCL5</a></span>, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/187011">187011</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:98262">98262</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2244">2244</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL5">CCL5</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000271503">CCL5 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/450px-Ideogram_human_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/600px-Ideogram_human_chromosome_17.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">Chromosome 17 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_17_ideogram.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/300px-Human_chromosome_17_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/450px-Human_chromosome_17_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/600px-Human_chromosome_17_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 121.34379999398px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CCL5"><img alt="Genomic location for CCL5" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 127.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CCL5"><img alt="Genomic location for CCL5" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">17q12</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">35,871,491 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">35,880,793 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/390px-Ideogram_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/520px-Ideogram_house_mouse_chromosome_11.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 11 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/300px-Ideogram_of_house_mouse_chromosome_11.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/450px-Ideogram_of_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/600px-Ideogram_of_house_mouse_chromosome_11.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 195.58114898652px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CCL5"><img alt="Genomic location for CCL5" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 201.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CCL5"><img alt="Genomic location for CCL5" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11 C|11 50.66 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">83,416,604 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">83,421,344 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000271503">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">gallbladder</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">epithelium of colon</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">bone marrow</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000035042">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">superior surface of tongue</li><br /><li style="line-height: 137%;">thymus</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">jejunum</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">subcutaneous adipose tissue</li><br /><li style="line-height: 137%;">Paneth cell</li><br /><li style="line-height: 137%;">right lung</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000271503">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CCL5_1405_i_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_CCL5_1405_i_at_fs.png/250px-PBB_GE_CCL5_1405_i_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_CCL5_1405_i_at_fs.png/375px-PBB_GE_CCL5_1405_i_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_CCL5_1405_i_at_fs.png/500px-PBB_GE_CCL5_1405_i_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CCL5_204655_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/PBB_GE_CCL5_204655_at_fs.png/250px-PBB_GE_CCL5_204655_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/PBB_GE_CCL5_204655_at_fs.png/375px-PBB_GE_CCL5_204655_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dd/PBB_GE_CCL5_204655_at_fs.png/500px-PBB_GE_CCL5_204655_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/6352/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031730">CCR5 chemokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030298">receptor signaling protein tyrosine kinase activator activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008009">chemokine activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043621">protein self-association</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031729">CCR4 chemokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004435">phosphatidylinositol phospholipase C activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004672">protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005125">cytokine activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031726">CCR1 chemokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016004">phospholipase activator activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042379">chemokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046817">chemokine receptor antagonist activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042056">chemoattractant activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048020">CCR chemokine receptor binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007159">leukocyte cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033634">positive regulation of cell-cell adhesion mediated by integrin</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050863">regulation of T cell activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014911">positive regulation of smooth muscle cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031584">activation of phospholipase D activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045071">negative regulation of viral genome replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070374">positive regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045089">positive regulation of innate immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071346">cellular response to interferon-gamma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010759">positive regulation of macrophage chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006816">calcium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006887">exocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051928">positive regulation of calcium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034097">response to cytokine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050796">regulation of insulin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070098">chemokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031328">positive regulation of cellular biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009615">response to virus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090026">positive regulation of monocyte chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044344">cellular response to fibroblast growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030593">neutrophil chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034612">response to tumor necrosis factor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070233">negative regulation of T cell apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043547">positive regulation of GTPase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000110">negative regulation of macrophage apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042102">positive regulation of T cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042327">positive regulation of phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045948">positive regulation of translational initiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009636">response to toxic substance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050679">positive regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042531">positive regulation of tyrosine phosphorylation of STAT protein</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071407">cellular response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006874">cellular calcium ion homeostasis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051262">protein tetramerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006935">chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034112">positive regulation of homotypic cell-cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071347">cellular response to interleukin-1</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006955">immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045070">positive regulation of viral genome replication</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046427">positive regulation of receptor signaling pathway via JAK-STAT</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031663">lipopolysaccharide-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000406">positive regulation of T cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002676">regulation of chronic inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048661">positive regulation of smooth muscle cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042119">neutrophil activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043491">protein kinase B signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030335">positive regulation of cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000503">positive regulation of natural killer cell chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007267">cell-cell signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048245">eosinophil chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002407">dendritic cell chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000165">MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048246">macrophage chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010820">positive regulation of T cell chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901214">regulation of neuron death</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014068">positive regulation of phosphatidylinositol 3-kinase signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045744">negative regulation of G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070234">positive regulation of T cell apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045785">positive regulation of cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070100">negative regulation of chemokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002548">monocyte chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050918">positive chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061098">positive regulation of protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071356">cellular response to tumor necrosis factor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010536">positive regulation of activation of Janus kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048247">lymphocyte chemotaxis</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6352&rn=1">6352</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20304&rn=1">20304</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000271503;db=core">ENSG00000271503</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000274233;db=core">ENSG00000274233</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000035042;db=core">ENSMUSG00000035042</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P13501">P13501</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P30882">P30882</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002985">NM_002985</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001278736">NM_001278736</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013653">NM_013653</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001265665">NP_001265665</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002976">NP_002976</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_038681">NP_038681</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr17:35871491-35880793">Chr 17: 35.87 – 35.88 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr11:83416604-83421344">Chr 11: 83.42 – 83.42 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14916093" class="extiw" title="d:Q14916093">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14916095" class="extiw" title="d:Q14916095">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Chemokine (C-C motif) ligand 5</b> (also <b>CCL5</b>) is a <a href="/wiki/Protein" title="Protein">protein</a> which in humans is encoded by the <i>CCL5</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1691736_5-0" class="reference"><a href="#cite_note-pmid1691736-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The gene has been discovered in 1990 by <a href="/wiki/In_situ_hybridization" title="In situ hybridization"><i>in situ</i> hybridisation</a> and it is localised on 17q11.2-q12 <a href="/wiki/Chromosome" title="Chromosome">chromosome</a>.<sup id="cite_ref-:0_6-0" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>It is also known as <b>RANTES</b> (<b>r</b>egulated on <b>a</b>ctivation, <b>n</b>ormal <a href="/wiki/T_cell" title="T cell"><b>T</b>-cell</a> <b>e</b>xpressed and <b>s</b>ecreted). RANTES was first described by Dr. Tom Schall who named the protein, the original source of the name Rantes was from the Argentine movie <i><a href="/wiki/Man_Facing_Southeast" title="Man Facing Southeast">Man Facing Southeast</a></i> about an alien who shows up in a mental ward who was named Rantés, the rather clunky acronym was only made to fit the name.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CCL5 belongs to the CC subfamily of <a href="/wiki/Chemokine" title="Chemokine">chemokines</a>, due to its adjacent <a href="/wiki/Cysteine" title="Cysteine">cysteines</a> near <a href="/wiki/N-terminus" title="N-terminus">N terminus</a>. It is an 8kDa <a href="/wiki/Protein" title="Protein">protein</a> acting as a classical <a href="/wiki/Chemotaxis" title="Chemotaxis">chemotactic</a> <a href="/wiki/Cytokine" title="Cytokine">cytokine</a> or <a href="/wiki/Chemokine" title="Chemokine">chemokine</a>. It consists of 68 <a href="/wiki/Amino_acid" title="Amino acid">amino acids</a>. CCL5 is proinflammatory chemokine, recruiting <a href="/wiki/White_blood_cell" title="White blood cell">leukocytes</a> to the site of <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>. It is chemotactic for <a href="/wiki/T_cell" title="T cell">T cells</a>, <a href="/wiki/Eosinophil" title="Eosinophil">eosinophils</a>, and <a href="/wiki/Basophil" title="Basophil">basophils</a>, but also for <a href="/wiki/Monocyte" title="Monocyte">monocytes</a>, <a href="/wiki/Natural_killer_cell" title="Natural killer cell">natural-killer (NK) cells</a>, <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cells</a> and <a href="/wiki/Mast_cell" title="Mast cell">mastocytes</a>.<sup id="cite_ref-:1_8-0" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> With the help of particular <a href="/wiki/Cytokine" title="Cytokine">cytokines</a> (i.e., <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> and <a href="/wiki/Interferon#Type_II_IFN" title="Interferon">IFN-γ</a>) that are released by T cells, CCL5 also induces the proliferation and activation of certain NK cells to form CHAK (CC-Chemokine-activated killer) cells.<sup id="cite_ref-pmid8617297_9-0" class="reference"><a href="#cite_note-pmid8617297-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> It is also an <a href="/wiki/HIV" title="HIV">HIV</a>-suppressive factor released from <a href="/wiki/Cytotoxic_T_cell" title="Cytotoxic T cell">CD8+ T cells</a> <sup id="cite_ref-pmid8525373_10-0" class="reference"><a href="#cite_note-pmid8525373-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The chemokine CCL5 is mainly expressed by T-cells and monocytes,<sup id="cite_ref-:2_11-0" class="reference"><a href="#cite_note-:2-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> and it has not been shown to be expressed by <a href="/wiki/B_cell" title="B cell">B-cells</a>.<sup id="cite_ref-:3_12-0" class="reference"><a href="#cite_note-:3-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Moreover, it is abundantly expressed by <a href="/wiki/Epithelial_cells" class="mw-redirect" title="Epithelial cells">epithelial cells</a>, <a href="/wiki/Fibroblast" title="Fibroblast">fibroblasts</a> and <a href="/wiki/Platelet" title="Platelet">thrombocytes</a>. Although it can bind to receptors <a href="/wiki/CCR1" title="CCR1">CCR1</a>, <a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a>, <a href="/wiki/CCR4" title="CCR4">CCR4</a> and <a href="/wiki/CCR5" title="CCR5">CCR5</a>, belonging to seven transmembrane G-protein coupled receptor (<a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">GPCRs</a>) family,<sup id="cite_ref-:1_8-1" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> it has the highest affinity to the CCR5. CCR5 is presented on the surface of T-cells, <a href="/wiki/Smooth_muscle" title="Smooth muscle">smooth muscle endothelial cells</a>, epithelial cells, <a href="/wiki/Parenchymal_cells" class="mw-redirect" title="Parenchymal cells">parenchymal cells</a> and other cell types. After the binding of CCL5 to CCR5, phosphoinositide 3-kinase (<a href="/wiki/Phosphoinositide_3-kinase" title="Phosphoinositide 3-kinase">PI3K</a>) is <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylated</a> and subsequently, the phosphorylated PI3K phosphorylates protein kinase B (PKB; also known as <a href="/wiki/Protein_kinase_B" title="Protein kinase B">Akt</a>) on the <a href="/wiki/Serine" title="Serine">serine</a> 473. Then, the Akt/PKB complex phosphorylates and inactivates a serine/threonine protein kinase <a href="/wiki/GSK-3" title="GSK-3">GSK-3</a>. After the CCL5/CCR5 binding, some other proteins are regulated as well. <a href="/wiki/Bcl-2" title="Bcl-2">Bcl2</a> is more expressed and it induces <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>. <a href="/wiki/Beta-catenin" class="mw-redirect" title="Beta-catenin">Beta-catenin</a> is phosphorylated and degraded. An important protein in the <a href="/wiki/Cell_cycle" title="Cell cycle">cell cycle</a>, <a href="/wiki/Cyclin_D" title="Cyclin D">Cyclin D</a>, is inhibited by inactivated GSK-3.<sup id="cite_ref-:2_11-1" class="reference"><a href="#cite_note-:2-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>CCL5 was first identified in a search for genes expressed "late" (3–5 days) after T cell activation. It was subsequently determined to be a <a href="/wiki/Chemokine#CC_chemokines" title="Chemokine">CC chemokine</a> and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (<a href="/wiki/KLF13" title="KLF13">KLF13</a>).<sup id="cite_ref-pmid2456327_13-0" class="reference"><a href="#cite_note-pmid2456327-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-isbn1-57059-253-5_14-0" class="reference"><a href="#cite_note-isbn1-57059-253-5-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10023774_15-0" class="reference"><a href="#cite_note-pmid10023774-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11138780_16-0" class="reference"><a href="#cite_note-pmid11138780-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> The <i>CCL5</i> gene is activated after 3–5 days after activation of T-cell via <a href="/wiki/T-cell_receptor" title="T-cell receptor">TCR</a>. This is different from the most of other chemokines which are released almost immediately after cell stimulation. Thus, CCL5 is involved in inflammation maintaining. It also induces expression of <a href="/wiki/Matrix_metalloproteinase" title="Matrix metalloproteinase">matrix metalloproteinases</a> which are important for migration of cells into the site of inflammation.<sup id="cite_ref-:3_12-1" class="reference"><a href="#cite_note-:3-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> CCL5 may be also expressed by NK cells. <a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">SP1 transcription factor</a> binds near to <i>CCL5</i> gene and mediates its constitutive <a href="/wiki/Messenger_RNA" title="Messenger RNA">mRNA</a> transcription. The transcription factor is regulated by the JNK/MAPK pathway.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Memory CD8+ T-cells are able to secrete CCL5 immediately after TCR stimulation, because they have a large number of preformed CCL5 mRNA in <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasm</a> and its secretion is dependent only on <a href="/wiki/Translation_(biology)" title="Translation (biology)">translation</a>.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p>RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells.<sup id="cite_ref-pmid8525373_10-1" class="reference"><a href="#cite_note-pmid8525373-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The RANTES protein has been engineered for <i>in vivo</i> production by <i><a href="/wiki/Lactobacillus" title="Lactobacillus">Lactobacillus</a></i> bacteria, and this solution is being developed into a possible HIV entry-inhibiting topical microbicide.<sup id="cite_ref-pmid20479208_19-0" class="reference"><a href="#cite_note-pmid20479208-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CCL5 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a>,<sup id="cite_ref-pmid8642344_20-0" class="reference"><a href="#cite_note-pmid8642344-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11449371_21-0" class="reference"><a href="#cite_note-pmid11449371-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> <a href="/wiki/CCR5" title="CCR5">CCR5</a><sup id="cite_ref-pmid11449371_21-1" class="reference"><a href="#cite_note-pmid11449371-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14637022_22-0" class="reference"><a href="#cite_note-pmid14637022-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11116158_23-0" class="reference"><a href="#cite_note-pmid11116158-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid_22265023_24-0" class="reference"><a href="#cite_note-pmid_22265023-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/CCR1" title="CCR1">CCR1</a>.<sup id="cite_ref-pmid11449371_21-2" class="reference"><a href="#cite_note-pmid11449371-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11116158_23-1" class="reference"><a href="#cite_note-pmid11116158-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>CCL5 also activates the G-protein coupled receptor <a href="/wiki/GPR75" title="GPR75">GPR75</a>.<sup id="cite_ref-pmid17001303_25-0" class="reference"><a href="#cite_note-pmid17001303-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>CCL5 has two mechanisms of action according to its concentration. </p> <ul><li>The first one occurs at low concentration of the chemokine. CCL5 may act as a <a href="/wiki/Monomer" title="Monomer">monomer</a> or a <a href="/wiki/Dimer_(chemistry)" class="mw-redirect" title="Dimer (chemistry)">dimer</a>. Dimerization is not necessary for binding to CCR5. Thus, CCL5 in nanomolar concentration acts as classical chemokine and binds to its receptor. For the acting as classical chemokine and for the dimerization, N terminus of the molecule is important.</li> <li>The second one occurs at high concentration of the chemokine. CCL5 creates self-aggregates binding to <a href="/wiki/Glycosaminoglycan" title="Glycosaminoglycan">glycosaminoglycans</a> (GAGs) on the cell surface. For that, Glu66 and Glu26 are important. These amino acids are presented on the protein surface and allows ion interactions. In the experiment where these molecules were exchanged for serine, the self-aggregation did not occur.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> <i><a href="/wiki/In_vitro" title="In vitro">In vitro</a></i>, the self-aggregates are strong activators of leukocytes. They can act as <a href="/wiki/Mitogen" title="Mitogen">mitogens</a> and they are not dependent on binding to the receptor. Activated T-cells (or other cells, for instance monocytes or <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a>) either proliferate or perform apoptosis, and they release proinflammatory cytokines, such as <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a>, <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a> and <a href="/wiki/Interferon_gamma" title="Interferon gamma">IFN-γ</a>.<sup id="cite_ref-:1_8-2" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> CCL5 mediated apoptosis in T-cells includes release of <a href="/wiki/Cytochrome_c" title="Cytochrome c">cytochrome c</a> in cytoplasm and the activation of <a href="/wiki/Caspase-9" title="Caspase-9">caspase-9</a> and <a href="/wiki/Caspase_3" title="Caspase 3">caspase-3</a>. The apoptosis is dependent on GAGs binding on cell surface and there is a requirement of at least 4 CCL5 molecules to induce the apoptosis.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=3" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CCL5 is involved in <a href="/wiki/Organ_transplantation" title="Organ transplantation">transplantations</a>,<sup id="cite_ref-:3_12-2" class="reference"><a href="#cite_note-:3-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> anti-viral immunity,<sup id="cite_ref-:1_8-3" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Tumor" class="mw-redirect" title="Tumor">tumor</a> development <sup id="cite_ref-:4_28-0" class="reference"><a href="#cite_note-:4-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> and numerous human diseases and disorders, for instance viral hepatitis or COVID-19.<sup id="cite_ref-:0_6-1" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:2_11-2" class="reference"><a href="#cite_note-:2-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>For instance, CCL5 level is higher during rejection of <a href="/wiki/Renal_transplant" class="mw-redirect" title="Renal transplant">renal transplant</a>.<sup id="cite_ref-:3_12-3" class="reference"><a href="#cite_note-:3-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>Importance of CCL5 is proved by various microbial strategies to avoid the activity of chemokine. For instance, <a href="/wiki/Human_cytomegalovirus" class="mw-redirect" title="Human cytomegalovirus">human cytomegalovirus</a> (HCMV) express a viral chemokine receptor analogue <a href="/w/index.php?title=US28&action=edit&redlink=1" class="new" title="US28 (page does not exist)">US28</a>, which sequesters CCL5. The chemokine is released by virus-specific activated <a href="/wiki/Cytotoxic_T_cell" title="Cytotoxic T cell">CD8+ T-cells</a> together with <a href="/wiki/Perforin" class="mw-redirect" title="Perforin">perforin</a> and <a href="/wiki/Granzyme_A" title="Granzyme A">granzyme A</a>. In cytotoxic T-cells (CTL) killing other cells via Fas/<a href="/wiki/FasL" class="mw-redirect" title="FasL">FasL</a> interaction, CCL5 increases <a href="/wiki/HIV" title="HIV">HIV</a>-specific T-cell cytotoxicity. Moreover, it is considered that CCL5 in low concentration might inhibit HIV replication. It binds to CCR5 (as well as 2 other chemokines) on the surface of <a href="/wiki/T_helper_cell" title="T helper cell">CD4+ T-cells</a>. CCR5 is used by HIV as an entrance molecule to a cell. On the contrary, CCL5 in high concentration might increase HIV replication.<sup id="cite_ref-:1_8-4" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The chemokine is involved also in antiviral response against other viruses. For instance, it has been shown that CCL5 is highly expressed in mice infected by <a href="/wiki/Lymphocytic_choriomeningitis_virus" class="mw-redirect" title="Lymphocytic choriomeningitis virus">lymphocytic choriomeningitis virus</a>. In CCL5 <a href="/wiki/Knock-out_mice" class="mw-redirect" title="Knock-out mice">knock-out mice</a>, virus-specific CD8+ T cells had reduced cytotoxic ability, reduced cytokines production and enhanced production of inhibitory molecules. It underscores the importance of CCL5 during chronic viral infection.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p><p>Increased levels of CCL5 was discovered in lots of cancers. For instance in <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a>,<sup id="cite_ref-:4_28-1" class="reference"><a href="#cite_note-:4-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>,<sup id="cite_ref-:0_6-2" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Stomach_cancer" title="Stomach cancer">stomach cancer</a>, <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> and <a href="/wiki/Pancreatic_cancer" title="Pancreatic cancer">pancreatic cancer</a>.<sup id="cite_ref-:2_11-3" class="reference"><a href="#cite_note-:2-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>CCL5 plays an important role in various human disorders, such as <a href="/wiki/Atherosclerosis" title="Atherosclerosis">atherosclerosis</a>, <a href="/wiki/COVID-19" title="COVID-19">COVID-19</a>, <a href="/wiki/SARS" title="SARS">SARS</a>,<sup id="cite_ref-:2_11-4" class="reference"><a href="#cite_note-:2-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Atopic_dermatitis" title="Atopic dermatitis">atopic dermatitis</a>, <a href="/wiki/Asthma" title="Asthma">asthma</a>, <a href="/wiki/Glomerulonephritis" title="Glomerulonephritis">glomerulonephritis</a>,<sup id="cite_ref-:1_8-5" class="reference"><a href="#cite_note-:1-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Alcoholic_liver_disease" title="Alcoholic liver disease">alcohol liver disease</a>, <a href="/wiki/Acute_liver_failure" title="Acute liver failure">acute liver failure</a> and <a href="/wiki/Viral_hepatitis" title="Viral hepatitis">viral hepatitis</a>.<sup id="cite_ref-:0_6-3" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=4" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Chemotaxis" title="Chemotaxis">Chemotaxis</a></li> <li><a href="/wiki/Chemokine" title="Chemokine">Chemokine</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span 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Douek DC (ed.). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141034">"A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection"</a>. <i>PLOS Pathogens</i>. <b>7</b> (7): e1002098. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.ppat.1002098">10.1371/journal.ppat.1002098</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141034">3141034</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21814510">21814510</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+Pathogens&rft.atitle=A+role+for+the+chemokine+RANTES+in+regulating+CD8+T+cell+responses+during+chronic+viral+infection&rft.volume=7&rft.issue=7&rft.pages=e1002098&rft.date=2011-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3141034%23id-name%3DPMC&rft_id=info%3Apmid%2F21814510&rft_id=info%3Adoi%2F10.1371%2Fjournal.ppat.1002098&rft.aulast=Crawford&rft.aufirst=A&rft.au=Angelosanto%2C+JM&rft.au=Nadwodny%2C+KL&rft.au=Blackburn%2C+SD&rft.au=Wherry%2C+EJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3141034&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACCL5" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=6" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CCL5"><i>CCL5</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CCL5"><i>CCL5</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P13501">P13501</a></i> (C-C motif chemokine 5) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CCL5&action=edit&section=7" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMuthumaniDesaiHwangChoo2004" class="citation journal cs1">Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, et al. (April 2004). "HIV-1 Vpr and anti-inflammatory activity". <i>DNA and Cell Biology</i>. <b>23</b> (4): 239–247. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1089%2F104454904773819824">10.1089/104454904773819824</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15142381">15142381</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=DNA+and+Cell+Biology&rft.atitle=HIV-1+Vpr+and+anti-inflammatory+activity&rft.volume=23&rft.issue=4&rft.pages=239-247&rft.date=2004-04&rft_id=info%3Adoi%2F10.1089%2F104454904773819824&rft_id=info%3Apmid%2F15142381&rft.aulast=Muthumani&rft.aufirst=K&rft.au=Desai%2C+BM&rft.au=Hwang%2C+DS&rft.au=Choo%2C+AY&rft.au=Laddy%2C+DJ&rft.au=Thieu%2C+KP&rft.au=Rao%2C+RG&rft.au=Weiner%2C+DB&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACCL5" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhaoElder2005" class="citation journal cs1">Zhao RY, Elder RT (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.cr.7290279">"Viral infections and cell cycle G2/M regulation"</a>. <i>Cell Research</i>. <b>15</b> (3): 143–149. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.cr.7290279">10.1038/sj.cr.7290279</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15780175">15780175</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Research&rft.atitle=Viral+infections+and+cell+cycle+G2%2FM+regulation&rft.volume=15&rft.issue=3&rft.pages=143-149&rft.date=2005-03&rft_id=info%3Adoi%2F10.1038%2Fsj.cr.7290279&rft_id=info%3Apmid%2F15780175&rft.aulast=Zhao&rft.aufirst=RY&rft.au=Elder%2C+RT&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.cr.7290279&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACCL5" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhaoBukrinskyElder2005" class="citation journal cs1">Zhao RY, Bukrinsky M, Elder RT (April 2005). 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rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.cr.7290370">"Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions"</a>. <i>Cell Research</i>. <b>15</b> (11–12): 923–934. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.cr.7290370">10.1038/sj.cr.7290370</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16354571">16354571</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Research&rft.atitle=Roles+of+HIV-1+auxiliary+proteins+in+viral+pathogenesis+and+host-pathogen+interactions&rft.volume=15&rft.issue=11%E2%80%9312&rft.pages=923-934&rft.date=2006&rft_id=info%3Adoi%2F10.1038%2Fsj.cr.7290370&rft_id=info%3Apmid%2F16354571&rft.aulast=Li&rft.aufirst=L&rft.au=Li%2C+HS&rft.au=Pauza%2C+CD&rft.au=Bukrinsky%2C+M&rft.au=Zhao%2C+RY&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.cr.7290370&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACCL5" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFIgnatovRobertGregory-EvansSchaller2006" class="citation journal cs1">Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014681">"RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75"</a>. <i>British Journal of Pharmacology</i>. <b>149</b> (5): 490–497. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.bjp.0706909">10.1038/sj.bjp.0706909</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014681">2014681</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17001303">17001303</a>.</cite><span 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href="/wiki/Template:PDB_Gallery" title="Template:PDB Gallery"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:PDB_Gallery" title="Template talk:PDB Gallery"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:PDB_Gallery" title="Special:EditPage/Template:PDB Gallery"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="PDB_gallery" style="font-size:114%;margin:0 4em">PDB gallery</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="gallery mw-gallery-traditional nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1b3a_EBI.jpg" class="mw-file-description" title="1b3a: TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES"><img alt="1b3a: TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/PDB_1b3a_EBI.jpg/180px-PDB_1b3a_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b1/PDB_1b3a_EBI.jpg/270px-PDB_1b3a_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b1/PDB_1b3a_EBI.jpg/360px-PDB_1b3a_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1b3a</b>: TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1eqt_EBI.jpg" class="mw-file-description" title="1eqt: MET-RANTES"><img alt="1eqt: MET-RANTES" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/180px-PDB_1eqt_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/270px-PDB_1eqt_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/81/PDB_1eqt_EBI.jpg/360px-PDB_1eqt_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1eqt</b>: MET-RANTES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1hrj_EBI.jpg" class="mw-file-description" title="1hrj: HUMAN RANTES, NMR, 13 STRUCTURES"><img alt="1hrj: HUMAN RANTES, NMR, 13 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e8/PDB_1hrj_EBI.jpg/180px-PDB_1hrj_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e8/PDB_1hrj_EBI.jpg/270px-PDB_1hrj_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e8/PDB_1hrj_EBI.jpg/360px-PDB_1hrj_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1hrj</b>: HUMAN RANTES, NMR, 13 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1rtn_EBI.jpg" class="mw-file-description" title="1rtn: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE"><img alt="1rtn: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/PDB_1rtn_EBI.jpg/180px-PDB_1rtn_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/PDB_1rtn_EBI.jpg/270px-PDB_1rtn_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/PDB_1rtn_EBI.jpg/360px-PDB_1rtn_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1rtn</b>: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1rto_EBI.jpg" class="mw-file-description" title="1rto: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE"><img alt="1rto: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/29/PDB_1rto_EBI.jpg/180px-PDB_1rto_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/29/PDB_1rto_EBI.jpg/270px-PDB_1rto_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/29/PDB_1rto_EBI.jpg/360px-PDB_1rto_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1rto</b>: PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1u4l_EBI.jpg" class="mw-file-description" title="1u4l: human RANTES complexed to heparin-derived disaccharide I-S"><img alt="1u4l: human RANTES complexed to heparin-derived disaccharide I-S" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1u4l_EBI.jpg/180px-PDB_1u4l_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1u4l_EBI.jpg/270px-PDB_1u4l_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/PDB_1u4l_EBI.jpg/360px-PDB_1u4l_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1u4l</b>: human RANTES complexed to heparin-derived disaccharide I-S</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1u4m_EBI.jpg" class="mw-file-description" title="1u4m: human RANTES complexed to heparin-derived disaccharide III-S"><img alt="1u4m: human RANTES complexed to heparin-derived disaccharide III-S" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/PDB_1u4m_EBI.jpg/180px-PDB_1u4m_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/PDB_1u4m_EBI.jpg/270px-PDB_1u4m_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ab/PDB_1u4m_EBI.jpg/360px-PDB_1u4m_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1u4m</b>: human RANTES complexed to heparin-derived disaccharide III-S</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1u4p_EBI.jpg" class="mw-file-description" title="1u4p: Crystal Structure of human RANTES mutant K45E"><img alt="1u4p: Crystal Structure of human RANTES mutant K45E" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1u4p_EBI.jpg/180px-PDB_1u4p_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1u4p_EBI.jpg/270px-PDB_1u4p_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1u4p_EBI.jpg/360px-PDB_1u4p_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1u4p</b>: Crystal Structure of human RANTES mutant K45E</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1u4r_EBI.jpg" class="mw-file-description" title="1u4r: Crystal Structure of human RANTES mutant 44-AANA-47"><img alt="1u4r: Crystal Structure of human RANTES mutant 44-AANA-47" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/PDB_1u4r_EBI.jpg/180px-PDB_1u4r_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/PDB_1u4r_EBI.jpg/270px-PDB_1u4r_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/PDB_1u4r_EBI.jpg/360px-PDB_1u4r_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1u4r</b>: Crystal Structure of human RANTES mutant 44-AANA-47</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_signaling:_cytokines" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokines" title="Template:Cytokines"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokines" title="Template talk:Cytokines"><abbr title="Discuss 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style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">CCL</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCL1" title="CCL1">CCL1</a></li> <li><a href="/wiki/CCL2" title="CCL2">CCL2</a>/MCP1</li> <li><a href="/wiki/CCL3" title="CCL3">CCL3</a>/MIP1α</li> <li><a href="/wiki/CCL4" title="CCL4">CCL4</a>/MIP1β</li> <li><a class="mw-selflink selflink">CCL5</a>/RANTES</li> <li><a href="/wiki/CCL6" title="CCL6">CCL6</a></li> <li><a href="/wiki/CCL7" title="CCL7">CCL7</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL9" title="CCL9">CCL9</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL12" title="CCL12">CCL12</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/wiki/CCL18" title="CCL18">CCL18</a>/PARC/DCCK1/AMAC1/MIP4</li> <li><a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL20" title="CCL20">CCL20</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li> <li><a href="/wiki/CCL22" title="CCL22">CCL22</a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li> <li><a href="/wiki/CCL24" title="CCL24">CCL24</a></li> <li><a href="/wiki/CCL25" title="CCL25">CCL25</a></li> <li><a href="/wiki/CCL26" title="CCL26">CCL26</a></li> <li><a href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CXCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CXCL1" title="CXCL1">CXCL1</a>/KC</li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">CXCL4</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/wiki/Interleukin_8" title="Interleukin 8">CXCL8/IL8</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11</a></li> <li><a href="/wiki/SDF-1_(biology)" class="mw-redirect" title="SDF-1 (biology)">CXCL12</a></li> <li><a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li> <li><a href="/wiki/CXCL14" title="CXCL14">CXCL14</a></li> <li><a href="/wiki/CXCL15" title="CXCL15">CXCL15</a></li> <li><a href="/wiki/CXCL16" title="CXCL16">CXCL16</a></li> <li><a href="/wiki/CXCL17" title="CXCL17">CXCL17</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CX3CL</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CX3CL1" title="CX3CL1">CX3CL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">XCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/XCL1" title="XCL1">XCL1</a></li> <li><a href="/wiki/XCL2" title="XCL2">XCL2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor_necrosis_factors" class="mw-redirect" title="Tumor necrosis factors">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li> <li><a href="/wiki/Lymphotoxin" title="Lymphotoxin">Lymphotoxin</a> <ul><li><a href="/wiki/Lymphotoxin_alpha" title="Lymphotoxin alpha">TNFB/LTA</a></li> <li><a href="/wiki/Lymphotoxin_beta" title="Lymphotoxin beta">TNFC/LTB</a></li></ul></li> <li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L">TNFSF4</a></li> <li><a href="/wiki/CD154" title="CD154">TNFSF5/CD40LG</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">TNFSF6</a></li> <li><a href="/wiki/CD70" title="CD70">TNFSF7</a></li> <li><a href="/wiki/CD153" title="CD153">TNFSF8</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">TNFSF9</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">TNFSF10</a></li> <li><a href="/wiki/RANKL" title="RANKL">TNFSF11</a></li> <li><a href="/wiki/A_proliferation-inducing_ligand" class="mw-redirect" title="A proliferation-inducing ligand">TNFSF13</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">TNFSF13B</a></li> <li><a href="/wiki/EDA_(gene)" class="mw-redirect" title="EDA (gene)">EDA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a><br />(grouped by<br />receptor<br />subunit)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_2" title="Interleukin 2">IL2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">IL15</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a>/<a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li> <li><a href="/wiki/Interleukin_7" title="Interleukin 7">IL7</a></li> <li><a href="/wiki/Interleukin_9" title="Interleukin 9">IL9</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">IL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CSF2RB" title="CSF2RB">β chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_3" title="Interleukin 3">IL3</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">GMCSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">IL6 like/<a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_11" title="Interleukin 11">IL11</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_30" title="Interleukin 30">IL30</a></li> <li><a href="/wiki/Interleukin_31" title="Interleukin 31">IL31</a> <ul><li>+non IL <a href="/wiki/Oncostatin_M" title="Oncostatin M">OSM</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">LIF</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor" title="Ciliary neurotrophic factor">CNTF</a></li> <li><a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">CTF1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=IL12_family&action=edit&redlink=1" class="new" title="IL12 family (page does not exist)">IL12 family</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_12" title="Interleukin 12">IL12</a></li> <li><a href="/wiki/Interleukin_23" title="Interleukin 23">IL23</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">IL35</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-taxilin" title="Alpha-taxilin">IL14</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">IL16</a></li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">IL32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">IL34</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL10_family" class="mw-redirect" title="IL10 family">IL10 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a>/<a href="/wiki/Interleukin_22" title="Interleukin 22">IL22</a></li> <li><a href="/wiki/Interleukin_19" title="Interleukin 19">IL19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">IL20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">IL24</a></li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">IL26</a></li> <li><a href="/wiki/Interferon_type_III" title="Interferon type III">Interferon type III</a> <ul><li><a href="/wiki/Interleukin_28" title="Interleukin 28">IL28/IFNL2+3</a></li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">IL29/IFNL1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon" title="Interferon">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_I" title="Interferon type I">I</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a></li> <li><a href="/wiki/IFNA2" title="IFNA2">IFNA2</a></li> <li><a href="/wiki/IFNA4" title="IFNA4">IFNA4</a></li> <li><a href="/wiki/IFNA5" title="IFNA5">IFNA5</a></li> <li><a href="/wiki/IFNA6" title="IFNA6">IFNA6</a></li> <li><a href="/wiki/IFNA7" title="IFNA7">IFNA7</a></li> <li><a href="/wiki/IFNA8" title="IFNA8">IFNA8</a></li> <li><a href="/wiki/IFNA10" title="IFNA10">IFNA10</a></li> <li><a href="/wiki/IFNA13" title="IFNA13">IFNA13</a></li> <li><a href="/wiki/IFNA14" title="IFNA14">IFNA14</a></li> <li><a href="/wiki/IFNA16" title="IFNA16">IFNA16</a></li> <li><a href="/wiki/IFNA17" title="IFNA17">IFNA17</a></li> <li><a href="/wiki/IFNA21" title="IFNA21">IFNA21</a></li> <li><a href="/wiki/IFNB1" title="IFNB1">IFNB1</a></li> <li><a href="/wiki/IFNK" title="IFNK">IFNK</a></li> <li><a href="/wiki/IFNW1" title="IFNW1">IFNW1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_II" class="mw-redirect" title="Interferon type II">II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNG</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_1_family" class="mw-redirect" title="Interleukin 1 family">IL1 family</a>: <a href="/wiki/IL1A" class="mw-redirect" title="IL1A">IL1A/IL1F1</a></li> <li><a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">IL1B/IL1F2</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">1Ra/IL1F3</a></li> <li><a href="/wiki/IL1F5" class="mw-redirect" title="IL1F5">IL1F5</a></li> <li><a href="/wiki/IL36A" title="IL36A">IL1F6</a></li> <li><a href="/wiki/IL1F7" class="mw-redirect" title="IL1F7">IL1F7</a></li> <li><a href="/wiki/IL36B" title="IL36B">IL1F8</a></li> <li><a href="/wiki/IL1F9" class="mw-redirect" title="IL1F9">IL1F9</a></li> <li><a href="/wiki/IL1F10" title="IL1F10">IL1F10</a></li> <li><a href="/wiki/Interleukin_33" title="Interleukin 33">33/IL1F11</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">18/IL1G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL17_family" class="mw-redirect" title="IL17 family">IL17 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_17" title="Interleukin 17">IL17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">IL25</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hematopoietic" class="mw-redirect" title="Hematopoietic">Hematopoietic</a> <ul><li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">KITLG</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li></ul></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">SPP1</a></li> <li><a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By function/<br />cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Proinflammatory_cytokine" class="mw-redirect" title="Proinflammatory cytokine">proinflammatory cytokine</a></i> <ul><li><a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">IL1</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li></ul></li></ul> <ul><li><a href="/wiki/Monokine" title="Monokine">Monokine</a></li> <li><a href="/wiki/Lymphokine" title="Lymphokine">Lymphokine</a> <ul><li><i>T<sub>h</sub>1</i> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNγ</a></li> <li><a href="/wiki/Tumor_necrosis_factor_beta" class="mw-redirect" title="Tumor necrosis factor beta">TNFβ</a></li></ul></li> <li><i>T<sub>h</sub>2</i> <ul><li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li></ul></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Chemokine_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chemokine_receptor_modulators" title="Template talk:Chemokine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chemokine_receptor_modulators" title="Special:EditPage/Template:Chemokine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Chemokine_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CC_chemokine_receptors" title="CC chemokine receptors">CC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR1" title="CCR1">CCR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL4" title="CCL4">CCL4 (MIP-1β)</a></li> <li><a class="mw-selflink selflink">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL6" title="CCL6">CCL6</a></li> <li><a href="/wiki/CCL9" title="CCL9">CCL9 (CCL10)</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR2" title="CCR2">CCR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL2" title="CCL2">CCL2</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL12" title="CCL12">CCL12</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> <ul><li><i>NAMs:</i> <a href="/wiki/Cenicriviroc" title="Cenicriviroc">Cenicriviroc (TAK-652, TBR-652)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a class="mw-selflink selflink">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL7" title="CCL7">CCL7</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL18" title="CCL18">CCL18</a></li> <li><a href="/wiki/CCL24" title="CCL24">CCL24</a></li> <li><a href="/wiki/CCL26" title="CCL26">CCL26</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR4" title="CCR4">CCR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL3" title="CCL3">CCL3 (MIP-1α)</a></li> <li><a class="mw-selflink selflink">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/wiki/CCL22" title="CCL22">CCL22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Mogamulizumab" title="Mogamulizumab">Mogamulizumab</a> (against CCR4)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR5" title="CCR5">CCR5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL3" title="CCL3">CCL3 (MIP-1α)</a></li> <li><a href="/wiki/CCL4" title="CCL4">CCL4 (MIP-1β)</a></li> <li><a class="mw-selflink selflink">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> <ul><li><i>NAMs:</i> <a href="/wiki/Aplaviroc" title="Aplaviroc">Aplaviroc</a></li> <li><a href="/wiki/Cenicriviroc" title="Cenicriviroc">Cenicriviroc (TAK-652, TBR-652)</a></li> <li><a href="/w/index.php?title=INCB009471&action=edit&redlink=1" class="new" title="INCB009471 (page does not exist)">INCB009471</a></li> <li><a href="/wiki/Maraviroc" title="Maraviroc">Maraviroc</a></li> <li><a href="/wiki/Vicriviroc" title="Vicriviroc">Vicriviroc</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/PRO_140" class="mw-redirect" title="PRO 140">PRO-140</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR6" class="mw-redirect" title="CCR6">CCR6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL20" title="CCL20">CCL20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR7" class="mw-redirect" title="CCR7">CCR7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR8" class="mw-redirect" title="CCR8">CCR8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL1" title="CCL1">CCL1</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR9" title="CCR9">CCR9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL25" title="CCL25">CCL25</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR10" title="CCR10">CCR10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR11" class="mw-redirect" title="CCR11">CCR11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li> <li><a href="/wiki/CCL25" title="CCL25">CCL25</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Antibodies:</i> <a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a> (against CCL11)</li> <li><a href="/wiki/Carlumab" title="Carlumab">Carlumab</a> (against CCL2)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR1" class="mw-redirect" title="CXCR1">CXCR1<br /><small>(IL-8Rα)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/w/index.php?title=Emoctakin&action=edit&redlink=1" class="new" title="Emoctakin (page does not exist)">Emoctakin</a></li> <li><a href="/wiki/Interleukin-8" class="mw-redirect" title="Interleukin-8">Interleukin-8 (CXCL8, GCP-1)</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=Navarixin&action=edit&redlink=1" class="new" title="Navarixin (page does not exist)">Navarixin</a></li></ul> <ul><li><i>NAMs:</i> <a href="/w/index.php?title=Ladarixin&action=edit&redlink=1" class="new" title="Ladarixin (page does not exist)">Ladarixin</a></li> <li><a href="/w/index.php?title=Reparixin&action=edit&redlink=1" class="new" title="Reparixin (page does not exist)">Reparixin (repertaxin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR2" class="mw-redirect" title="CXCR2">CXCR2<br /><small>(IL-8Rβ)</small></a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL1" title="CXCL1">CXCL1 (MGSA)</a></li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/w/index.php?title=Emoctakin&action=edit&redlink=1" class="new" title="Emoctakin (page does not exist)">Emoctakin</a></li> <li><a href="/w/index.php?title=Garnocestim&action=edit&redlink=1" class="new" title="Garnocestim (page does not exist)">Garnocestim</a></li> <li><a href="/wiki/Interleukin-8" class="mw-redirect" title="Interleukin-8">Interleukin-8 (CXCL8, GCP-1)</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=Danirixin&action=edit&redlink=1" class="new" title="Danirixin (page does not exist)">Danirixin</a></li> <li><a href="/w/index.php?title=Elubrixin&action=edit&redlink=1" class="new" title="Elubrixin (page does not exist)">Elubrixin</a></li> <li><a href="/w/index.php?title=Navarixin&action=edit&redlink=1" class="new" title="Navarixin (page does not exist)">Navarixin</a></li></ul> <ul><li><i>NAMs:</i> <a href="/w/index.php?title=Ladarixin&action=edit&redlink=1" class="new" title="Ladarixin (page does not exist)">Ladarixin</a></li> <li><a href="/w/index.php?title=Reparixin&action=edit&redlink=1" class="new" title="Reparixin (page does not exist)">Reparixin (repertaxin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR3" title="CXCR3">CXCR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL4" class="mw-redirect" title="CXCL4">CXCL4 (PF4)</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9 (MIG)</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10 (IP-10)</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11 (I-TAC)</a></li> <li><a href="/w/index.php?title=Iroplact&action=edit&redlink=1" class="new" title="Iroplact (page does not exist)">Iroplact</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Eldelumab" title="Eldelumab">Eldelumab</a> (against CXCL10)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR4" title="CXCR4">CXCR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li> <li><a href="/wiki/Stromal_cell-derived_factor_1" title="Stromal cell-derived factor 1">SDF-1 (CXCL12)</a></li> <li><a href="/wiki/Ubiquitin" title="Ubiquitin">Ubiquitin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Mavorixafor" title="Mavorixafor">Mavorixafor</a></li> <li><a href="/wiki/Plerixafor" title="Plerixafor">Plerixafor (AMD3100)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ulocuplumab" title="Ulocuplumab">Ulocuplumab</a> (against CXCR4)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR5" title="CXCR5">CXCR5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR6" title="CXCR6">CXCR6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL16" title="CXCL16">CXCL16</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/ACKR3" title="ACKR3">CXCR7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Conolidine" title="Conolidine">Conolidine</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11 (I-TAC)</a></li> <li><a href="/w/index.php?title=CCX771&action=edit&redlink=1" class="new" title="CCX771 (page does not exist)">CCX771</a></li> <li><a href="/wiki/LIH383" title="LIH383">LIH383</a></li> <li><a href="/wiki/RTI-5152-12" title="RTI-5152-12">RTI-5152-12</a></li> <li><a href="/wiki/Stromal_cell-derived_factor_1" title="Stromal cell-derived factor 1">SDF-1 (CXCL12)</a></li> <li><a href="/w/index.php?title=VUF15485&action=edit&redlink=1" class="new" title="VUF15485 (page does not exist)">VUF15485</a></li></ul> <ul><li><i>PAMs:</i> <a href="/wiki/Plerixafor" title="Plerixafor">Plerixafor (AMD3100)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/C_chemokine_receptor" class="mw-redirect" title="C chemokine receptor">C (XC)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="XCR1" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/XCR1" title="XCR1">XCR1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/XCL1" title="XCL1">Lymphotactin-α (XCL1)</a></li> <li><a href="/wiki/XCL2" title="XCL2">Lymphotactin-β (XCL2)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Pateclizumab" title="Pateclizumab">Pateclizumab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3C</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="CX3CR1" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3CR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Fractalkine" class="mw-redirect" title="Fractalkine">Fractalkine (CX3CL1)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCBP2" title="CCBP2">CCBP2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CC_chemokine" class="mw-redirect" title="CC chemokine">CC (β) chemokines</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CMKLR1" title="CMKLR1">CMKLR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Chemerin" title="Chemerin">Chemerin</a></li> <li><a href="/w/index.php?title=Resolvin_E1&action=edit&redlink=1" class="new" title="Resolvin E1 (page does not exist)">Resolvin E1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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