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<div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p><b>Tamulotoxin</b> (or Tamulus toxin, Tamulustoxin, in short form: TmTx) is a venomous neurotoxin from the Indian Red Scorpion (<i><a href="/wiki/Hottentotta_tamulus" title="Hottentotta tamulus">Hottentotta tamulus</a></i>, <i>Mesobuthus tamulus</i> or <i>Buthus tamulus</i>). </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=1" title="Edit section: Chemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Structure">Structure</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The toxin has been classified as a short-chain scorpion toxin.<sup id="cite_ref-Strong_1-0" class="reference"><a href="#cite_note-Strong-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> It consists of 36 amino acids and is referred to as TmTx1.<sup id="cite_ref-Vega_2-0" class="reference"><a href="#cite_note-Vega-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> A peptide consisting of 35 amino acids has also been identified,<sup id="cite_ref-Strong_1-1" class="reference"><a href="#cite_note-Strong-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> referred to as TmTx2.<sup id="cite_ref-Vega_2-1" class="reference"><a href="#cite_note-Vega-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> It possesses three intra-molecular disulphide bonds (S-S), leading to a highly stabilized conformation. It also has six cysteine residues which is a characteristic shared by many short-chain scorpion toxins. </p> <div class="mw-heading mw-heading3"><h3 id="Family">Family</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=3" title="Edit section: Family"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>TmTx belongs to the short scorpion toxin superfamily and the potassium channel inhibitor family.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Adhering to the nomenclature of Tytgat et al.,<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> potassium toxins can be divided into four subgroups: alpha, beta, gamma and kappa. It belongs to the group of alpha potassium toxins (α-KTx: alpha toxin affecting potassium channels). This group contains short-chain peptides of 23-42 acids with three or four disulphide bridges. The primary targets consist of voltage-gated Shaker-related potassium channels, ether-a-go-go related gene (<a href="/wiki/HERG" title="HERG">HERG</a>) potassium channels in the heart and calcium activated potassium channels. Within this family, TmTx belongs to the α-KTx 16 subfamily. </p> <div class="mw-heading mw-heading3"><h3 id="Homology">Homology</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=4" title="Edit section: Homology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>TmTx shows no homology with other species of scorpion toxins in <a href="/wiki/BLAST_(biotechnology)" title="BLAST (biotechnology)">BLAST</a> of the TmTx sequence,<sup id="cite_ref-Strong_1-2" class="reference"><a href="#cite_note-Strong-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> apart from the position of its six cysteine residues. It is nevertheless categorized with other potassium channel scorpion toxins, because it shares the position of its six cysteine residues with other toxins. In phylogeny, TmTx does have similarities with other scorpion neurotoxins.<sup id="cite_ref-Vega_2-2" class="reference"><a href="#cite_note-Vega-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Target_and_mode_of_action">Target and mode of action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=5" title="Edit section: Target and mode of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A comparative model has been suggested for the 3D protein structure of TmTx by using information from homologous proteins with known structures.<sup id="cite_ref-Kumar_5-0" class="reference"><a href="#cite_note-Kumar-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Based on this model, it is highly likely that TmTx blocks <a href="/wiki/Calcium_activated_potassium_channel" class="mw-redirect" title="Calcium activated potassium channel">calcium activated potassium channels</a> by binding to the S5-S6 segment and thus blocking its pore. The active site of TmTx in this model consists of 5 amino acids, which is essential for the activity of TmTx. These amino acids would be responsible for inhibiting transport of ions. On the other hand, TmTx does not seem to inhibit [<sup>125</sup>I] apamin binding to synaptic membranes in the rat brain or ionomycin-induced 86Rb<sup>+</sup> fluxes in C6 cells in vitro.<sup id="cite_ref-Strong_1-3" class="reference"><a href="#cite_note-Strong-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> This suggests that TmTx does not have an effect on <a href="/wiki/SK_channel" title="SK channel">SK channels</a> or charybdotoxin-sensitive IK channels (<a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel">calcium-activated potassium channel</a>), respectively. Another suggested target is the Kv1.6 channel,<sup id="cite_ref-Strong_1-4" class="reference"><a href="#cite_note-Strong-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> a <a href="/wiki/Voltage-gated_potassium_channel" title="Voltage-gated potassium channel">voltage-gated potassium channel</a>. There are two suggestions for the mode of action. Either it works via blocking the open channel, or there could be a modulation of slow inactivation of this channel. Upon wash, a complete reversal of the block occurred, suggesting that the binding of the toxin to the channel is not very strong. </p> <div class="mw-heading mw-heading2"><h2 id="Toxicity">Toxicity</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=6" title="Edit section: Toxicity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Injection of the venom of H. tamulus in rats induces hyperventilatory and hypertensive responses <sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and in humans.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The toxicity of the venom varies with age and species.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=7" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Based on the structure, biological compounds can be identified which could have a maximum binding affinity to the active site of TmTx toxin protein and thereby preventing the toxin to bind to the ionic pore of the channel.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Therefore, these compounds could in future be used as an antidote for TmTx. Three bioactive compounds have been identified from the plants <i><a href="/wiki/Andrographis_paniculata" title="Andrographis paniculata">Andrographis paniculata</a></i> and <i><a href="/wiki/Ocimum_basilicum" class="mw-redirect" title="Ocimum basilicum">Ocimum basilicum</a></i>. Based on computer models, separate ligands have also been identified, which could block TmTx.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Tamulotoxin&action=edit&section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Strong-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Strong_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Strong_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Strong_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Strong_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Strong_1-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFStrongClarkArmugamDe-Allie2001" class="citation journal cs1">Strong, PN; Clark, GS; Armugam, A; De-Allie, FA; Joseph, JS; Yemul, V; Deshpande, JM; Kamat, R; Gadre, SV; Gopalakrisnakone, P; Kini, RM; Owen, DG; Jeyaseelan, K (1 January 2001). 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacognosy+Journal&rft.atitle=Computational+analysis+of+bioactive+phytochemicals+as+potential+inhibitors+for+calcium+activated+potassium+channel+blocker%2C+tamulotoxin+from+Mesobuthus+tamulus&rft.volume=5&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E41-%3C%2Fspan%3E45&rft.date=2013-04&rft_id=info%3Adoi%2F10.1016%2Fj.phcgj.2013.02.001&rft.aulast=Kumar&rft.aufirst=RB&rft.au=Suresh%2C+MX&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATamulotoxin" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKumarSuresh2013" class="citation journal cs1">Kumar, RB; Suresh, MX (April 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680861">"Pharmacophore mapping based inhibitor selection and molecular interaction studies for identification of potential drugs on calcium activated potassium channel blockers, tamulotoxin"</a>. <i>Pharmacognosy Magazine</i>. <b>9</b> (34): <span class="nowrap">89–</span>95. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.4103%2F0973-1296.111239">10.4103/0973-1296.111239</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680861">3680861</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23772102">23772102</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacognosy+Magazine&rft.atitle=Pharmacophore+mapping+based+inhibitor+selection+and+molecular+interaction+studies+for+identification+of+potential+drugs+on+calcium+activated+potassium+channel+blockers%2C+tamulotoxin&rft.volume=9&rft.issue=34&rft.pages=%3Cspan+class%3D%22nowrap%22%3E89-%3C%2Fspan%3E95&rft.date=2013-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3680861%23id-name%3DPMC&rft_id=info%3Apmid%2F23772102&rft_id=info%3Adoi%2F10.4103%2F0973-1296.111239&rft.aulast=Kumar&rft.aufirst=RB&rft.au=Suresh%2C+MX&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3680861&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATamulotoxin" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output 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style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <i><a href="/wiki/Dihydropyridine" class="mw-redirect" title="Dihydropyridine">Dihydropyridines</a>:</i> <a href="/wiki/Amlodipine" title="Amlodipine">Amlodipine</a></li> <li><a href="/wiki/Aranidipine" title="Aranidipine">Aranidipine</a></li> <li><a href="/wiki/Azelnidipine" title="Azelnidipine">Azelnidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Barnidipine</a></li> <li><a href="/wiki/Clevidipine" title="Clevidipine">Clevidipine</a></li> <li><a href="/w/index.php?title=Cronidipine&action=edit&redlink=1" class="new" title="Cronidipine (page does not exist)">Cronidipine</a></li> <li><a href="/wiki/Darodipine" title="Darodipine">Darodipine</a></li> <li><a href="/w/index.php?title=Dexniguldipine&action=edit&redlink=1" class="new" title="Dexniguldipine (page does not exist)">Dexniguldipine</a></li> <li><a href="/w/index.php?title=Elgodipine&action=edit&redlink=1" class="new" title="Elgodipine (page does not exist)">Elgodipine</a></li> <li><a href="/w/index.php?title=Elnadipine&action=edit&redlink=1" class="new" title="Elnadipine (page does not exist)">Elnadipine</a></li> <li><a href="/wiki/Felodipine" title="Felodipine">Felodipine</a></li> <li><a href="/w/index.php?title=Flordipine&action=edit&redlink=1" class="new" title="Flordipine (page does not exist)">Flordipine</a></li> <li><a href="/w/index.php?title=Furnidipine&action=edit&redlink=1" class="new" title="Furnidipine (page does not exist)">Furnidipine</a></li> <li><a href="/w/index.php?title=Iganidipine&action=edit&redlink=1" class="new" title="Iganidipine (page does not exist)">Iganidipine</a></li> <li><a href="/wiki/Isradipine" title="Isradipine">Isradipine</a></li> <li><a href="/wiki/Lacidipine" title="Lacidipine">Lacidipine</a></li> <li><a href="/w/index.php?title=Lemildipine&action=edit&redlink=1" class="new" title="Lemildipine (page does not exist)">Lemildipine</a></li> <li><a href="/wiki/Lercanidipine" title="Lercanidipine">Lercanidipine</a></li> <li><a href="/wiki/Levamlodipine" title="Levamlodipine">Levamlodipine</a></li> <li><a href="/w/index.php?title=Levniguldipine&action=edit&redlink=1" class="new" title="Levniguldipine (page does not exist)">Levniguldipine</a></li> <li><a href="/wiki/Manidipine" title="Manidipine">Manidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Mepirodipine</a></li> <li><a href="/w/index.php?title=Mesudipine&action=edit&redlink=1" class="new" title="Mesudipine (page does not exist)">Mesudipine</a></li> <li><a href="/wiki/Nicardipine" title="Nicardipine">Nicardipine</a></li> <li><a href="/wiki/Nifedipine" title="Nifedipine">Nifedipine</a></li> <li><a href="/wiki/Niguldipine" title="Niguldipine">Niguldipine</a></li> <li><a href="/wiki/Niludipine" title="Niludipine">Niludipine</a></li> <li><a href="/wiki/Nilvadipine" title="Nilvadipine">Nilvadipine</a></li> <li><a href="/wiki/Nimodipine" title="Nimodipine">Nimodipine</a></li> <li><a href="/wiki/Nisoldipine" title="Nisoldipine">Nisoldipine</a></li> <li><a href="/wiki/Nitrendipine" title="Nitrendipine">Nitrendipine</a></li> <li><a href="/w/index.php?title=Olradipine&action=edit&redlink=1" class="new" title="Olradipine (page does not exist)">Olradipine</a></li> <li><a href="/wiki/Oxodipine" title="Oxodipine">Oxodipine</a></li> <li><a href="/w/index.php?title=Palonidipine&action=edit&redlink=1" class="new" title="Palonidipine (page does not exist)">Palonidipine</a></li> <li><a href="/wiki/Pranidipine" title="Pranidipine">Pranidipine</a></li> <li><a href="/wiki/Riodipine" title="Riodipine">Ryodipine (riodipine)</a></li> <li><a href="/w/index.php?title=Sagandipine&action=edit&redlink=1" class="new" title="Sagandipine (page does not exist)">Sagandipine</a></li> <li><a href="/w/index.php?title=Sornidipine&action=edit&redlink=1" class="new" title="Sornidipine (page does not exist)">Sornidipine</a></li> <li><a href="/w/index.php?title=Teludipine&action=edit&redlink=1" class="new" title="Teludipine (page does not exist)">Teludipine</a></li> <li><a href="/w/index.php?title=Tiamdipine&action=edit&redlink=1" class="new" title="Tiamdipine (page does not exist)">Tiamdipine</a></li> <li><a href="/w/index.php?title=Trombodipine&action=edit&redlink=1" class="new" title="Trombodipine (page does not exist)">Trombodipine</a></li> <li><a href="/w/index.php?title=Vatanidipine&action=edit&redlink=1" class="new" title="Vatanidipine (page does not exist)">Vatanidipine</a>; <i><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a> derivatives:</i> <a href="/wiki/Clentiazem" title="Clentiazem">Clentiazem</a></li> <li><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a></li> <li><a href="/w/index.php?title=Iprotiazem&action=edit&redlink=1" class="new" title="Iprotiazem (page does not exist)">Iprotiazem</a></li> <li><a href="/w/index.php?title=Nictiazem&action=edit&redlink=1" class="new" title="Nictiazem (page does not exist)">Nictiazem</a></li> <li><a href="/w/index.php?title=Siratiazem&action=edit&redlink=1" class="new" title="Siratiazem (page does not exist)">Siratiazem</a>; <i><a href="/wiki/Arylalkylamine" title="Arylalkylamine">Phenylalkylamines</a>:</i> <a href="/wiki/Anipamil" title="Anipamil">Anipamil</a></li> <li><a href="/w/index.php?title=Dagapamil&action=edit&redlink=1" class="new" title="Dagapamil (page does not exist)">Dagapamil</a></li> <li><a href="/wiki/Devapamil" title="Devapamil">Devapamil</a></li> <li><a href="/w/index.php?title=Dexverapamil&action=edit&redlink=1" class="new" title="Dexverapamil (page does not exist)">Dexverapamil</a></li> <li><a href="/wiki/Emopamil" title="Emopamil">Emopamil</a></li> <li><a href="/w/index.php?title=Etripamil&action=edit&redlink=1" class="new" title="Etripamil (page does not exist)">Etripamil</a></li> <li><a href="/wiki/Falipamil" title="Falipamil">Falipamil</a></li> <li><a href="/wiki/Gallopamil" title="Gallopamil">Gallopamil</a></li> <li><a href="/w/index.php?title=Levemopamil&action=edit&redlink=1" class="new" title="Levemopamil (page does not exist)">Levemopamil</a></li> <li><a href="/w/index.php?title=Nexopamil&action=edit&redlink=1" class="new" title="Nexopamil (page does not exist)">Nexopamil</a></li> <li><a href="/wiki/Norverapamil" title="Norverapamil">Norverapamil</a></li> <li><a href="/w/index.php?title=Ronipamil&action=edit&redlink=1" class="new" title="Ronipamil (page does not exist)">Ronipamil</a></li> <li><a href="/wiki/Tiapamil" title="Tiapamil">Tiapamil</a></li> <li><a href="/wiki/Verapamil" title="Verapamil">Verapamil</a>; <i>Others:</i> <a href="/wiki/AH-1058" title="AH-1058">AH-1058</a></li> <li><a href="/w/index.php?title=Brinazarone&action=edit&redlink=1" class="new" title="Brinazarone (page does not exist)">Brinazarone</a></li> <li><a href="/wiki/Budiodarone" title="Budiodarone">Budiodarone</a></li> <li><a href="/wiki/Celivarone" title="Celivarone">Celivarone</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Fantofarone" title="Fantofarone">Fantofarone</a></li> <li><a href="/w/index.php?title=SR-33805&action=edit&redlink=1" class="new" title="SR-33805 (page does not exist)">SR-33805</a></li> <li><a href="/wiki/Tetrahydropalmatine" title="Tetrahydropalmatine">Tetrahydropalmatine</a></li></ul> <ul><li><b><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N-type-selective</a>:</b> <a href="/wiki/%CE%A9-Conotoxin" class="mw-redirect" title="Ω-Conotoxin">ω-Conotoxins</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_GVIA&action=edit&redlink=1" class="new" title="Ω-Conotoxin GVIA (page does not exist)">ω-Conotoxin GVIA</a></li> <li><a href="/wiki/Caroverine" title="Caroverine">Caroverine</a></li> <li><a href="/w/index.php?title=Huwentoxin_XVI&action=edit&redlink=1" class="new" title="Huwentoxin XVI (page does not exist)">Huwentoxin XVI</a></li> <li><a href="/wiki/Leconotide" title="Leconotide">Leconotide (ω-conotoxin CVID)</a></li> <li><a href="/w/index.php?title=PD-173212&action=edit&redlink=1" class="new" title="PD-173212 (page does not exist)">PD-173212</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/w/index.php?title=Z160&action=edit&redlink=1" class="new" title="Z160 (page does not exist)">Z160</a></li> <li><a href="/wiki/Ziconotide" title="Ziconotide">Ziconotide (ω-conotoxin MVIIA)</a></li></ul> <ul><li><b><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P-type-selective</a>:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_IVA&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVA (page does not exist)">ω-Agatoxin IVA</a></li> <li><a href="/w/index.php?title=%CE%A9-Agatoxin_IVB&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVB (page does not exist)">ω-Agatoxin IVB</a></li></ul> <ul><li><b><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R-type-selective</a>:</b> <a href="/wiki/SNX-482" title="SNX-482">SNX-482</a></li></ul> <ul><li><b><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T-type-selective</a>:</b> <a href="/w/index.php?title=ABT-639&action=edit&redlink=1" class="new" title="ABT-639 (page does not exist)">ABT-639</a></li> <li><a href="/w/index.php?title=ML-218&action=edit&redlink=1" class="new" title="ML-218 (page does not exist)">ML-218</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=NNC_55-0396&action=edit&redlink=1" class="new" title="NNC 55-0396 (page does not exist)">NNC 55-0396</a></li> <li><a href="/w/index.php?title=ProTx_I&action=edit&redlink=1" class="new" title="ProTx I (page does not exist)">ProTx I</a></li> <li><a href="/w/index.php?title=Z944&action=edit&redlink=1" class="new" title="Z944 (page does not exist)">Z944</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><b>Non-selective:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_TK&action=edit&redlink=1" class="new" title="Ω-Agatoxin TK (page does not exist)">ω-Agatoxin TK</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_MVIIC&action=edit&redlink=1" class="new" title="Ω-Conotoxin MVIIC (page does not exist)">ω-Conotoxin MVIIC</a></li> <li><a href="/wiki/Benidipine" title="Benidipine">Benidipine</a></li> <li><a href="/wiki/Bepridil" title="Bepridil">Bepridil</a></li> <li><a href="/wiki/Cilnidipine" title="Cilnidipine">Cilnidipine</a></li> <li><a href="/wiki/Cinnarizine" title="Cinnarizine">Cinnarizine</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Efonidipine" title="Efonidipine">Efonidipine</a></li> <li><a href="/wiki/Flunarizine" title="Flunarizine">Flunarizine</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Levetiracetam" title="Levetiracetam">Levetiracetam</a></li> <li><a href="/wiki/Lomerizine" title="Lomerizine">Lomerizine</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/w/index.php?title=NP078585&action=edit&redlink=1" class="new" title="NP078585 (page does not exist)">NP078585</a></li> <li><a href="/wiki/Ruthenium_red" title="Ruthenium red">Ruthenium red</a></li> <li><a href="/wiki/TROX-1" title="TROX-1">TROX-1</a></li></ul> <ul><li><b><a href="/wiki/Voltage-dependent_calcium_channel#α2δ_Subunit" class="mw-redirect" title="Voltage-dependent calcium channel">α<sub>2</sub>δ subunit</a>-selective (<a href="/wiki/Gabapentinoid" title="Gabapentinoid">gabapentinoids</a>):</b> <a href="/wiki/4-Methylpregabalin" title="4-Methylpregabalin">4-Methylpregabalin</a></li> <li><a href="/wiki/Arbaclofen" class="mw-redirect" title="Arbaclofen">Arbaclofen</a></li> <li><a href="/wiki/Arbaclofen_placarbil" title="Arbaclofen placarbil">Arbaclofen placarbil</a></li> <li><a href="/wiki/Atagabalin" title="Atagabalin">Atagabalin</a></li> <li><a href="/wiki/Baclofen" title="Baclofen">Baclofen</a></li> <li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Imagabalin" title="Imagabalin">Imagabalin</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/w/index.php?title=PD-200,347&action=edit&redlink=1" class="new" title="PD-200,347 (page does not exist)">PD-200,347</a></li> <li><a href="/wiki/PD-217,014" title="PD-217,014">PD-217,014</a></li> <li><a href="/w/index.php?title=PD-299,685&action=edit&redlink=1" class="new" title="PD-299,685 (page does not exist)">PD-299,685</a></li> <li><a href="/wiki/Phenibut" title="Phenibut">Phenibut</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li></ul> <ul><li><b>Others/unsorted:</b> <a href="/wiki/Bencyclane" title="Bencyclane">Bencyclane</a></li> <li><a href="/wiki/Berbamine" title="Berbamine">Berbamine</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a href="/wiki/Canadine" title="Canadine">Canadine</a></li> <li><a href="/wiki/Carboxyamidotriazole" title="Carboxyamidotriazole">Carboxyamidotriazole</a></li> <li><a href="/wiki/Cycleanine" title="Cycleanine">Cycleanine</a></li> <li><a href="/wiki/Dauricine" title="Dauricine">Dauricine</a></li> <li><a href="/wiki/Dimeditiapramine" class="mw-redirect" title="Dimeditiapramine">Dimeditiapramine</a></li> <li><a href="/wiki/Diproteverine" title="Diproteverine">Diproteverine</a></li> <li><a href="/wiki/Enpiperate" title="Enpiperate">Enpiperate</a></li> <li><a href="/wiki/Eperisone" title="Eperisone">Eperisone</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Ethadione" title="Ethadione">Ethadione</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Fasudil" title="Fasudil">Fasudil</a></li> <li><a href="/wiki/Fendiline" title="Fendiline">Fendiline</a></li> <li><a href="/wiki/Fostedil" title="Fostedil">Fostedil</a></li> <li><a href="/wiki/Imepitoin" title="Imepitoin">Imepitoin</a></li> <li><a href="/wiki/JTV-519" title="JTV-519">JTV-519</a></li> <li><a href="/wiki/Lidoflazine" title="Lidoflazine">Lidoflazine</a></li> <li><a href="/wiki/Magnesium" title="Magnesium">Magnesium</a></li> <li><a href="/wiki/Manoalide" title="Manoalide">Manoalide</a></li> <li><a href="/wiki/Mesuximide" title="Mesuximide">Mesuximide</a></li> <li><a href="/wiki/Monatepil" title="Monatepil">Monatepil</a></li> <li><a href="/wiki/Naftopidil" title="Naftopidil">Naftopidil</a></li> <li><a href="/wiki/Ochratoxin_A" title="Ochratoxin A">Ochratoxin A</a></li> <li><a href="/wiki/Osthol" title="Osthol">Osthol</a></li> <li><a href="/wiki/Otilonium_bromide" title="Otilonium bromide">Otilonium bromide</a></li> <li><a href="/wiki/Paramethadione" title="Paramethadione">Paramethadione</a></li> <li><a href="/wiki/Phensuximide" title="Phensuximide">Phensuximide</a></li> <li><a href="/wiki/Pinaverium_bromide" title="Pinaverium bromide">Pinaverium bromide</a></li> <li><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a></li> <li><a href="/wiki/Rhynchophylline" title="Rhynchophylline">Rhynchophylline</a></li> <li><a href="/wiki/Sesamodil" title="Sesamodil">Sesamodil</a></li> <li><a href="/wiki/Silperisone" title="Silperisone">Silperisone</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Tetrandrine" title="Tetrandrine">Tetrandrine</a></li> <li><a href="/wiki/Tolperisone" title="Tolperisone">Tolperisone</a></li> <li><a href="/wiki/Trimethadione" title="Trimethadione">Trimethadione</a></li> <li><a href="/wiki/Valperinol" title="Valperinol">Valperinol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_opener" title="Calcium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <a href="/wiki/Bay_K8644" title="Bay K8644">Bay K8644</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Potassium_channel" title="Potassium channel">Potassium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_potassium_channels" class="mw-redirect" title="Voltage-gated potassium channels"><abbr title="Voltage-gated potassium channels">VGKCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated potassium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3,4-Diaminopyridine" class="mw-redirect" title="3,4-Diaminopyridine">3,4-Diaminopyridine (amifampridine)</a></li> <li><a href="/wiki/4-Aminopyridine" title="4-Aminopyridine">4-Aminopyridine (fampridine/dalfampridine)</a></li> <li><a href="/w/index.php?title=Adekalant&action=edit&redlink=1" class="new" title="Adekalant (page does not exist)">Adekalant</a></li> <li><a href="/wiki/Almokalant" title="Almokalant">Almokalant</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bretylium" title="Bretylium">Bretylium</a></li> <li><a href="/wiki/Bunaftine" title="Bunaftine">Bunaftine</a></li> <li><a href="/wiki/Charybdotoxin" title="Charybdotoxin">Charybdotoxin</a></li> <li><a href="/w/index.php?title=Clamikalant&action=edit&redlink=1" class="new" title="Clamikalant (page does not exist)">Clamikalant</a></li> <li><a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/w/index.php?title=Dalazatide&action=edit&redlink=1" class="new" title="Dalazatide (page does not exist)">Dalazatide</a></li> <li><a href="/wiki/Dendrotoxin" title="Dendrotoxin">Dendrotoxin</a></li> <li><a href="/wiki/Dofetilide" title="Dofetilide">Dofetilide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Hanatoxin" title="Hanatoxin">Hanatoxin</a></li> <li><a href="/wiki/HgeTx1" title="HgeTx1">HgeTx1</a></li> <li><a href="/wiki/HsTx1" title="HsTx1">HsTx1</a></li> <li><a href="/wiki/Ibutilide" title="Ibutilide">Ibutilide</a></li> <li><a href="/w/index.php?title=Inakalant&action=edit&redlink=1" class="new" title="Inakalant (page does not exist)">Inakalant</a></li> <li><a href="/wiki/Kaliotoxin" title="Kaliotoxin">Kaliotoxin</a></li> <li><a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/wiki/Lolitrem_B" title="Lolitrem B">Lolitrem B</a></li> <li><a href="/wiki/Maurotoxin" title="Maurotoxin">Maurotoxin</a></li> <li><a href="/wiki/Nifekalant" title="Nifekalant">Nifekalant</a></li> <li><a href="/w/index.php?title=Notoxin&action=edit&redlink=1" class="new" title="Notoxin (page does not exist)">Notoxin</a></li> <li><a href="/wiki/Paxilline" title="Paxilline">Paxilline</a></li> <li><a href="/w/index.php?title=Pinokalant&action=edit&redlink=1" class="new" title="Pinokalant (page does not exist)">Pinokalant</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/w/index.php?title=ShK-186&action=edit&redlink=1" class="new" title="ShK-186 (page does not exist)">ShK-186</a></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Tedisamil" title="Tedisamil">Tedisamil</a></li> <li><a href="/w/index.php?title=Terikalant&action=edit&redlink=1" class="new" title="Terikalant (page does not exist)">Terikalant</a></li> <li><a href="/wiki/Tetraethylammonium" title="Tetraethylammonium">Tetraethylammonium</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/HERG" title="HERG">hERG</a> (KCNH2, K<sub>v</sub>11.1)-specific:</b> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/AmmTX3" title="AmmTX3">AmmTX3</a></li> <li><a href="/wiki/Astemizole" title="Astemizole">Astemizole</a></li> <li><a href="/wiki/Azaspiracid" title="Azaspiracid">Azaspiracid</a></li> <li><a href="/wiki/AZD1305" title="AZD1305">AZD1305</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bedaquiline" title="Bedaquiline">Bedaquiline</a></li> <li><a href="/wiki/BeKm-1_toxin" title="BeKm-1 toxin">BeKm-1</a></li> <li><a href="/wiki/BmTx3" title="BmTx3">BmTx3</a></li> <li><a href="/wiki/BRL-32872" title="BRL-32872">BRL-32872</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Cisapride" title="Cisapride">Cisapride</a></li> <li><a href="/wiki/Clarithromycin" title="Clarithromycin">Clarithromycin</a></li> <li><a href="/wiki/Darifenacin" title="Darifenacin">Darifenacin</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a></li> <li><a href="/wiki/Diallyl_trisulfide" title="Diallyl trisulfide">Diallyl trisulfide</a></li> <li><a href="/wiki/Domperidone" title="Domperidone">Domperidone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Ergtoxin" title="Ergtoxin">Ergtoxins</a></li> <li><a href="/wiki/Erythromycin" title="Erythromycin">Erythromycin</a></li> <li><a href="/wiki/Gigactonine" title="Gigactonine">Gigactonine</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Norpropoxyphene" title="Norpropoxyphene">Norpropoxyphene</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li> <li><a href="/wiki/PNU-282,987" title="PNU-282,987">PNU-282,987</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li> <li><a href="/wiki/Roxithromycin" title="Roxithromycin">Roxithromycin</a></li> <li><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></li> <li><a href="/wiki/Solifenacin" title="Solifenacin">Solifenacin</a></li> <li><a class="mw-selflink selflink">Tamulotoxin</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Terfenadine" title="Terfenadine">Terfenadine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Tolterodine" title="Tolterodine">Tolterodine</a></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/w/index.php?title=XE-991&action=edit&redlink=1" class="new" title="XE-991 (page does not exist)">XE-991</a></li> <li><a href="/wiki/Ssm_spooky_toxin" title="Ssm spooky toxin">Spooky toxin (SsTx)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a></li> <li><a href="/wiki/Retigabine" title="Retigabine">Retigabine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Inwardly_rectifying_potassium_channel" class="mw-redirect" title="Inwardly rectifying potassium channel"><abbr title="Inwardly rectifying potassium channel">IRKs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Inwardly rectifying potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/wiki/Acetohexamide" title="Acetohexamide">Acetohexamide</a></li> <li><a href="/wiki/Carbutamide" title="Carbutamide">Carbutamide</a></li> <li><a href="/wiki/Chlorpropamide" title="Chlorpropamide">Chlorpropamide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide (glyburide)</a></li> <li><a href="/wiki/Glibornuride" title="Glibornuride">Glibornuride</a></li> <li><a href="/wiki/Glicaramide" title="Glicaramide">Glicaramide</a></li> <li><a href="/wiki/Gliclazide" title="Gliclazide">Gliclazide</a></li> <li><a href="/wiki/Glimepiride" title="Glimepiride">Glimepiride</a></li> <li><a href="/wiki/Glipizide" title="Glipizide">Glipizide</a></li> <li><a href="/wiki/Gliquidone" title="Gliquidone">Gliquidone</a></li> <li><a href="/wiki/Glisoxepide" title="Glisoxepide">Glisoxepide</a></li> <li><a href="/wiki/Glyclopyramide" title="Glyclopyramide">Glyclopyramide</a></li> <li><a href="/w/index.php?title=Glycyclamide&action=edit&redlink=1" class="new" title="Glycyclamide (page does not exist)">Glycyclamide</a></li> <li><a href="/wiki/Metahexamide" title="Metahexamide">Metahexamide</a></li> <li><a href="/wiki/Mitiglinide" title="Mitiglinide">Mitiglinide</a></li> <li><a href="/wiki/Nateglinide" title="Nateglinide">Nateglinide</a></li> <li><a href="/wiki/Repaglinide" title="Repaglinide">Repaglinide</a></li> <li><a href="/wiki/Tolazamide" title="Tolazamide">Tolazamide</a></li> <li><a href="/wiki/Tolbutamide" title="Tolbutamide">Tolbutamide</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/wiki/Barium" title="Barium">Barium</a></li> <li><a href="/wiki/Caramiphen" title="Caramiphen">Caramiphen</a></li> <li><a href="/wiki/Cloperastine" title="Cloperastine">Cloperastine</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Ifenprodil" title="Ifenprodil">Ifenprodil</a></li> <li><a href="/wiki/Tertiapin" title="Tertiapin">Tertiapin</a></li> <li><a href="/wiki/Tipepidine" title="Tipepidine">Tipepidine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/w/index.php?title=Aprikalim&action=edit&redlink=1" class="new" title="Aprikalim (page does not exist)">Aprikalim</a></li> <li><a href="/wiki/Bimakalim" title="Bimakalim">Bimakalim</a></li> <li><a href="/wiki/Cromakalim" title="Cromakalim">Cromakalim</a></li> <li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li> <li><a href="/w/index.php?title=Emakalim&action=edit&redlink=1" class="new" title="Emakalim (page does not exist)">Emakalim</a></li> <li><a href="/wiki/Levcromakalim" class="mw-redirect" title="Levcromakalim">Levcromakalim</a></li> <li><a href="/w/index.php?title=Mazokalim&action=edit&redlink=1" class="new" title="Mazokalim (page does not exist)">Mazokalim</a></li> <li><a href="/wiki/Minoxidil" title="Minoxidil">Minoxidil</a></li> <li><a href="/wiki/Minoxidil_sulfate" title="Minoxidil sulfate">Minoxidil sulfate</a></li> <li><a href="/w/index.php?title=Naminidil&action=edit&redlink=1" class="new" title="Naminidil (page does not exist)">Naminidil</a></li> <li><a href="/wiki/Nicorandil" title="Nicorandil">Nicorandil</a></li> <li><a href="/wiki/Pinacidil" title="Pinacidil">Pinacidil</a></li> <li><a href="/w/index.php?title=Rilmakalim&action=edit&redlink=1" class="new" title="Rilmakalim (page does not exist)">Rilmakalim</a></li> <li><a href="/w/index.php?title=Sarakalim&action=edit&redlink=1" class="new" title="Sarakalim (page does not exist)">Sarakalim</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/w/index.php?title=ML-297&action=edit&redlink=1" class="new" title="ML-297 (page does not exist)">ML-297 (VU0456810)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel"><abbr title="Calcium-activated potassium channel">K<sub>Ca</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/GAL-021" class="mw-redirect" title="GAL-021">GAL-021</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Rottlerin" title="Rottlerin">Rottlerin (mallotoxin)</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Tandem_pore_domain_potassium_channel" class="mw-redirect" title="Tandem pore domain potassium channel"><abbr title="Tandem pore domain potassium channel">K2Ps</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Tandem pore domain potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/12-O-Tetradecanoylphorbol-13-acetate" title="12-O-Tetradecanoylphorbol-13-acetate">12-O-Tetradecanoylphorbol-13-acetate</a></li> <li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Norfluoxetine" class="mw-redirect" title="Norfluoxetine">Norfluoxetine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Riluzole" title="Riluzole">Riluzole</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Sodium_channel" title="Sodium channel">Sodium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_sodium_channels" class="mw-redirect" title="Voltage-gated sodium channels"><abbr title="Voltage-gated sodium channels">VGSCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated sodium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Antianginals:</i> <a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li></ul> <ul><li><i>Antiarrhythmics (class I):</i> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Aprindine" title="Aprindine">Aprindine</a></li> <li><a href="/wiki/Disopyramide" title="Disopyramide">Disopyramide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Encainide" title="Encainide">Encainide</a></li> <li><a href="/wiki/Flecainide" title="Flecainide">Flecainide</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Lorajmine" title="Lorajmine">Lorajmine</a></li> <li><a href="/wiki/Lorcainide" title="Lorcainide">Lorcainide</a></li> <li><a href="/wiki/Mexiletine" title="Mexiletine">Mexiletine</a></li> <li><a href="/wiki/Moracizine" title="Moracizine">Moricizine</a></li> <li><a href="/wiki/Pilsicainide" title="Pilsicainide">Pilsicainide</a></li> <li><a href="/wiki/Prajmaline" title="Prajmaline">Prajmaline</a></li> <li><a href="/wiki/Procainamide" title="Procainamide">Procainamide</a></li> <li><a href="/wiki/Propafenone" title="Propafenone">Propafenone</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Sparteine" title="Sparteine">Sparteine</a></li> <li><a href="/wiki/Tocainide" title="Tocainide">Tocainide</a></li></ul> <ul><li><i>Anticonvulsants:</i> <a href="/w/index.php?title=Acetylpheneturide&action=edit&redlink=1" class="new" title="Acetylpheneturide (page does not exist)">Acetylpheneturide</a></li> <li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Cenobamate" title="Cenobamate">Cenobamate</a></li> <li><a href="/wiki/Chlorphenacemide" title="Chlorphenacemide">Chlorphenacemide</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Eslicarbazepine_acetate" title="Eslicarbazepine acetate">Eslicarbazepine acetate</a></li> <li><a href="/wiki/Ethotoin" title="Ethotoin">Ethotoin</a></li> <li><a href="/wiki/Fosphenytoin" title="Fosphenytoin">Fosphenytoin</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Lacosamide" title="Lacosamide">Lacosamide</a></li> <li><a href="/wiki/Licarbazepine" title="Licarbazepine">Licarbazepine</a></li> <li><a href="/wiki/Mephenytoin" title="Mephenytoin">Mephenytoin</a></li> <li><a href="/wiki/Oxcarbazepine" title="Oxcarbazepine">Oxcarbazepine</a></li> <li><a href="/wiki/Oxitriptyline" title="Oxitriptyline">Oxitriptyline</a></li> <li><a href="/wiki/Phenacemide" title="Phenacemide">Phenacemide</a></li> <li><a href="/wiki/Pheneturide" title="Pheneturide">Pheneturide</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/Rufinamide" title="Rufinamide">Rufinamide</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/wiki/Sodium_valproate" class="mw-redirect" title="Sodium valproate">Sodium valproate</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li> <li><a href="/wiki/Valproate_pivoxil" title="Valproate pivoxil">Valproate pivoxil</a></li> <li><a href="/wiki/Valproate_semisodium" class="mw-redirect" title="Valproate semisodium">Valproate semisodium</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li> <li><a href="/wiki/Valpromide" title="Valpromide">Valpromide</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><i>Local anesthetics:</i> <a href="/wiki/3-(p-Fluorobenzoyloxy)tropane" title="3-(p-Fluorobenzoyloxy)tropane"><i>p</i>FBT</a></li> <li><a href="/wiki/Amylocaine" title="Amylocaine">Amylocaine</a></li> <li><a href="/wiki/Articaine" title="Articaine">Articaine</a></li> <li><a href="/wiki/Benzocaine" title="Benzocaine">Benzocaine</a></li> <li><a href="/wiki/Bupivacaine" title="Bupivacaine">Bupivacaine</a> (<a href="/wiki/Levobupivacaine" title="Levobupivacaine">Levobupivacaine</a>, <a href="/wiki/Ropivacaine" title="Ropivacaine">Ropivacaine</a>)</li> <li><a href="/wiki/Butacaine" title="Butacaine">Butacaine</a></li> <li><a href="/wiki/Butamben" title="Butamben">Butamben</a></li> <li><a href="/wiki/Chloroprocaine" title="Chloroprocaine">Chloroprocaine</a></li> <li><a href="/wiki/Cinchocaine" title="Cinchocaine">Cinchocaine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Cyclomethycaine" title="Cyclomethycaine">Cyclomethycaine</a></li> <li><a href="/wiki/Dimethocaine" title="Dimethocaine">Dimethocaine</a></li> <li><a href="/wiki/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a></li> <li><a href="/wiki/Etidocaine" title="Etidocaine">Etidocaine</a></li> <li><a href="/wiki/Hexylcaine" title="Hexylcaine">Hexylcaine</a></li> <li><a href="/wiki/Iontocaine" title="Iontocaine">Iontocaine</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Mepivacaine" title="Mepivacaine">Mepivacaine</a></li> <li><a href="/wiki/Meprylcaine" title="Meprylcaine">Meprylcaine</a></li> <li><a href="/wiki/Metabutoxycaine" title="Metabutoxycaine">Metabutoxycaine</a></li> <li><a href="/wiki/Orthocaine" title="Orthocaine">Orthocaine</a></li> <li><a href="/wiki/Piperocaine" title="Piperocaine">Piperocaine</a></li> <li><a href="/wiki/Prilocaine" title="Prilocaine">Prilocaine</a></li> <li><a href="/wiki/Procaine" title="Procaine">Procaine</a></li> <li><a href="/wiki/Propoxycaine" title="Propoxycaine">Propoxycaine</a></li> <li><a href="/wiki/Proxymetacaine" title="Proxymetacaine">Proxymetacaine</a></li> <li><a href="/wiki/Risocaine" title="Risocaine">Risocaine</a></li> <li><a href="/wiki/Tetracaine" title="Tetracaine">Tetracaine</a></li> <li><a href="/wiki/Trimecaine" title="Trimecaine">Trimecaine</a></li></ul> <ul><li><i>Analgesics:</i> <a href="/w/index.php?title=AZD-3161&action=edit&redlink=1" class="new" title="AZD-3161 (page does not exist)">AZD-3161</a></li> <li><a href="/wiki/DSP-2230" title="DSP-2230">DSP-2230</a></li> <li><a href="/wiki/Funapide" title="Funapide">Funapide</a></li> <li><a href="/w/index.php?title=GDC-0276&action=edit&redlink=1" class="new" title="GDC-0276 (page does not exist)">GDC-0276</a></li> <li><a href="/w/index.php?title=NKTR-171&action=edit&redlink=1" class="new" title="NKTR-171 (page does not exist)">NKTR-171</a></li> <li><a href="/w/index.php?title=PF-04531083&action=edit&redlink=1" class="new" title="PF-04531083 (page does not exist)">PF-04531083</a></li> <li><a href="/wiki/PF-05089771" title="PF-05089771">PF-05089771</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Raxatrigine" class="mw-redirect" title="Raxatrigine">Raxatrigine</a></li> <li><a href="/w/index.php?title=RG7893&action=edit&redlink=1" class="new" title="RG7893 (page does not exist)">RG7893 (GDC-0287)</a></li> <li><a href="/wiki/Suzetrigine" title="Suzetrigine">Suzetrigine</a></li></ul> <ul><li><i>Toxins:</i> <a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/wiki/Neosaxitoxin" title="Neosaxitoxin">Neosaxitoxin</a></li> <li><a href="/wiki/Saxitoxin" title="Saxitoxin">Saxitoxin</a></li> <li><a href="/wiki/Tetrodotoxin" title="Tetrodotoxin">Tetrodotoxin</a></li> <li><a href="/wiki/Zetekitoxin_AB" title="Zetekitoxin AB">Zetekitoxin AB</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Evenamide" title="Evenamide">Evenamide</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a> (<a href="/wiki/Mentha" title="Mentha">mint</a>)</li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aconitine" title="Aconitine">Aconitine</a></li> <li>Atracotoxins (<a href="/wiki/Omega-Atracotoxin" title="Omega-Atracotoxin">ω-Atracotoxin</a>, <a href="/wiki/Robustoxin" class="mw-redirect" title="Robustoxin">Robustoxin</a>, <a href="/wiki/Versutoxin" title="Versutoxin">Versutoxin</a>)</li> <li><a href="/wiki/Batrachotoxin" title="Batrachotoxin">Batrachotoxin</a></li> <li><a href="/wiki/Ciguatoxin" title="Ciguatoxin">Ciguatoxins</a></li> <li><a href="/wiki/Grayanotoxin" title="Grayanotoxin">Grayanotoxins</a></li> <li><a href="/wiki/Poneratoxin" title="Poneratoxin">Poneratoxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel"><abbr title="Epithelial sodium channel">ENaC</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Epithelial sodium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Benzamil" title="Benzamil">Benzamil</a></li> <li><a href="/wiki/Triamterene" title="Triamterene">Triamterene</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Solnatide&action=edit&redlink=1" class="new" title="Solnatide (page does not exist)">Solnatide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Acid-sensing_ion_channel" title="Acid-sensing ion channel"><abbr title="Acid-sensing ion channel">ASICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Acid-sensing ion channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=A-317567&action=edit&redlink=1" class="new" title="A-317567 (page does not exist)">A-317567</a></li> <li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Aspirin" title="Aspirin">Aspirin</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a></li> <li><a href="/w/index.php?title=PcTX1&action=edit&redlink=1" class="new" title="PcTX1 (page does not exist)">PcTX1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chloride_channel" title="Chloride channel">Chloride</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_chloride_channel" class="mw-redirect" title="Calcium-activated chloride channel"><abbr title="Calcium-activated chloride channel">CaCCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated chloride channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Crofelemer" title="Crofelemer">Crofelemer</a></li> <li><a href="/wiki/DIDS" title="DIDS">DIDS</a></li> <li><a href="/wiki/Ethacrynic_acid" class="mw-redirect" title="Ethacrynic acid">Ethacrynic acid</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Furosemide" title="Furosemide">Furosemide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Mefloquine" title="Mefloquine">Mefloquine</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbachol" title="Carbachol">Carbachol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator"><abbr title="Cystic fibrosis transmembrane conductance regulator">CFTR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cystic fibrosis transmembrane conductance regulator</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Lonidamine" title="Lonidamine">Lonidamine</a></li> <li><a href="/wiki/Piretanide" title="Piretanide">Piretanide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=1,7-Phenanthroline&action=edit&redlink=1" class="new" title="1,7-Phenanthroline (page does not exist)">1,7-Phenanthroline</a></li> <li><a href="/wiki/1,10-Phenanthroline" title="1,10-Phenanthroline">1,10-Phenanthroline</a></li> <li><a href="/w/index.php?title=4,7-Phenanthroline&action=edit&redlink=1" class="new" title="4,7-Phenanthroline (page does not exist)">4,7-Phenanthroline</a></li> <li><a href="/w/index.php?title=7,8-Benzoquinoline&action=edit&redlink=1" class="new" title="7,8-Benzoquinoline (page does not exist)">7,8-Benzoquinoline</a></li> <li><a href="/wiki/Ivacaftor" title="Ivacaftor">Ivacaftor</a></li> <li><a href="/wiki/Phenanthridine" title="Phenanthridine">Phenanthridine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bumetanide" title="Bumetanide">Bumetanide</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></li> <li><a href="/wiki/Mepacrine" title="Mepacrine">Mepacrine</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=Talniflumate&action=edit&redlink=1" class="new" title="Talniflumate (page does not exist)">Talniflumate</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Transient_receptor_potential_channels" class="mw-redirect" title="Transient receptor potential channels"><abbr title="Transient receptor potential channels">TRPs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Transient receptor potential channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Ligand_gated_ion_channels" class="mw-redirect" title="Ligand gated ion channels"><abbr title="Ligand gated ion channels">LGICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Ligand gated ion channels</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Pharmacomodulation" title="Template:Pharmacomodulation">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">Transient receptor potential channel modulators</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" 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