ICTR Drug Discovery and Development Core - University of Maryland, Baltimore

<!doctype html>     <html class="no-js" lang="en" dir="ltr">  <head> <title>ICTR Drug Discovery and Development Core - University of Maryland, Baltimore</title>  <meta name="google-site-verification" content="87z-qwjh5RVGSWXfHQ0WcuKh08WXq-hvqAThddxH4I8" /> <meta name="google-site-verification" content="l1pkXsIP-M-kzPF-9gzbAXrRKPlr4Dix-SzteqSZkOo" />  <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta charset="UTF-8" /> <meta name="author" content="University of Maryland, Baltimore"> <meta name="generator" content="TerminalFour Site Manager">  <meta name="description" content="ICTR Drug Discovery and Development Resources " /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <meta name="apple-mobile-web-app-capable" content="yes" />    <link rel="icon" type="image/png" href="/media/umb/style-assets/images/umb-favicon-01.png">   <link rel="stylesheet" href="https://use.typekit.net/itl7jxg.css"> <link href="https://netdna.bootstrapcdn.com/font-awesome/4.0.3/css/font-awesome.css" rel="stylesheet">  <link rel="stylesheet" href="/media/umb/style-assets/css/bootstrap.min.css" type="text/css" /> <link rel="stylesheet" href="/media/umb/style-assets/css/header-1_ls.css" type="text/css" /> <link rel="stylesheet" href="/media/umb/style-assets/css/bootstrap/bootstrap.min.css" type="text/css"/> <link rel="stylesheet" href="/media/umb/style-assets/css/internal_landingstyles.css" type="text/css"/>  <link href="/media/umb/style-assets/css/menu3d_ls.css" rel="stylesheet" media="screen, projection" /> <link href="/media/umb/style-assets/css/animate.css" rel="stylesheet" type="text/css" /> <link href="/media/umb/style-assets/css/skin_ls.css" rel="stylesheet" type="text/css" />  <link rel="stylesheet" href="/media/umb/style-assets/css/style_ls.css" type="text/css"/> <link rel="stylesheet" href="/media/umb/style-assets/css/mockup_customizations.css" type="text/css"/> <link rel="stylesheet" href="/media/umb/style-assets/css/header_customizations_jp.css" type="text/css"/> <link rel="stylesheet" href="/media/umb/style-assets/css/index_slider.css" type="text/css"/> <link rel="stylesheet" href="/media/umb/style-assets/css/custom_jp.css" type="text/css"/>  <link rel="stylesheet" href="/media/umb/style-assets/css/branded_nonav.css" type="text/css" />  <link rel="stylesheet" href="/media/umb/style-assets/css/Common_Calendar.css" type="text/css"/>  <link rel="stylesheet" href="/media/umb/ictr/web-template-style-assets/ictr-styles.css" type="text/css"/>   <meta property="og:title" content="ICTR Drug Discovery and Development Core" /> <meta property="og:image" content="https://www.umaryland.edu/media/umb/style-assets/images/og-image-01.png"/> <meta property="og:description" content="The University of Maryland, Baltimore (UMB) is the state’s public health, law, and human services university devoted to excellence in professional and graduate education, research, patient care, and public service." /> <meta property="og:type" content="website" /> <meta property="og:site_name" content="University of Maryland, Baltimore" /> <meta property="og:locale" content="en_us" /> <meta name="google-site-verification" content="5CDdNqy6DcHL88e1j90T2cuPet0dx97hpAZD9WE6KXI" />  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MJ4QGMJ');</script>  <meta name="facebook-domain-verification" content="2t61mlfuyp9ml5b624aul3jrc1qa06" />    <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.9.1/jquery.min.js"></script> <script>window.jQuery || document.write('<script src=/media/umb/style-assets/javascript/jquery-1.9.1.min.js"><\/script>')</script>    <script src="/media/umb/style-assets/javascript/modernizr.js"></script>  <script src="/media/umb/style-assets/javascript/jquery-1.10.1.min.js" type="text/javascript"></script>  <script src="/media/umb/style-assets/javascript/bootstrap.js" type="text/javascript"></script>   </head> <body class="index-flex-light umb-template" itemscope="" itemtype="http://schema.org/WebPage">  <noscript role="application" aria-label="Google Tag Manager"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MJ4QGMJ" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>     <div id="header-body-wrap"> <div class="preheaderBar"></div>  <ul class="visuallyhidden" id="top"> <li><a href="#page" title="Skip to content" accesskey="c">Skip to content</a></li> </ul>    <header class="clearfix"> <div class="header_alert"> <link rel="stylesheet" href="/media/umb/style-assets/css/alert_styles.css" type="text/css"/>  </div> <div class="standalone-top-bar"><div class="container"> ICTR is affiliated with the <a href="http://www.umaryland.edu">University of Maryland, Baltimore</a> </div></div> <div class="headerBar_nonav headerBar_basicnav"> <div class="container"> <div class="row-fluid"> <div id="preheadwrap"> <section class="container preheader"> <div class="span12 "> <ul class="residentportal"> <li><a href="https://myumb.umaryland.edu/">My UMB</a></li> <li><a href="https://cfapps.umaryland.edu/directory/">Directory</a></li> <li><a href="http://www.umaryland.edu/maps/">Map</a></li> <li><a href="http://calendar.umaryland.edu">Calendar</a></li> <li class="branded-nonav-search"><form class="search-bar" id="cse-search-box" method="get" action="https://www.umaryland.edu/ictr/search-results/"> <input type="text" name="q" id="query" placeholder="Search" title="Search" > </form></li> </ul>  </div> </section> </div> </div> </div> <div class="container" id="brandwrapper"> <div class="row-fluid"> <div class="span6"> <div class="branding"><a href="/ictr/"><img src="/media/umb/ictr/web-template-style-assets/ictr-logo-web.png" alt="The University of Maryland Institute for Clinical & Translational Research" ></a></div> </div> <div class="span6 hidden-phone" id="locatedIn"> </div> </div> </div> </div>  <div class="fullwidth-content-wrapper-basicnav ictr-customnav"> <div class="row-fluid general_content container"> <div class="span12"> <div class="fullwidth-content clearfix"> <div class="span2"> <p><a href="/ictr/about-umb-ictr/">About UMB ICTR</a></p> </div> <div class="span2"> <p><a href="/ictr/for-the-community/">For the Community</a></p> </div> <div class="span2"> <p><a href="/ictr/investigator-resources/">Investigator Resources</a></p> </div> <div class="span2"> <p><a href="/ictr/funding/">Funding</a></p> </div> <div class="span2"> <p><a href="/ictr/education-and-training/">Education & Training</a></p> </div> <a class="support-bandednonav" href="http://umaryland.edu/ictr/give">Support ICTR</a> </div> </div> </div> </div>  </header>   <div id="page">  <img id="logo-for-print" src="/media/umb/ictr/web-template-style-assets/ictr-logo-web.png" style="display:none;" alt="The University of Maryland Institute for Clinical & Translational Research" > <div class="container visible-phone"> </div> <div class="hero-unit"> <div class="container"> <div class="row-fluid"> <ul class="breadcrumb" itemprop="breadcrumb" itemscope itemtype="http://schema.org/BreadcrumbList" ><li itemprop="itemListElement"><a href="/">UMB Home</a></li><li itemprop="itemListElement"><a href="/research/">Research</a></li><li itemprop="itemListElement"><a href="/research/umb-research-profile/">UMB Research Profile</a></li><li itemprop="itemListElement"><a href="/research/umb-research-profile/research-centers-and-institutions/">Organized Research Centers and Institutes</a></li><li itemprop="itemListElement"><a href="/ictr/">UMB ICTR</a></li><li itemprop="itemListElement"><a href="/ictr/investigator-resources/">Investigator Resources</a></li><li itemprop="itemListElement">ICTR Drug Discovery and Development Core</li></ul> </div> <div class="row-fluid"> <h1><span itemscope itemtype="http://schema.org/WebSite" > <a href="/ictr/" itemprop="url"> <span itemprop="name"> UMB ICTR </span> </a> </span> </h1> </div>  </div>  </div>   <div class="container clearfix" id="main-content">   <div class="row-fluid sidebar-left">  <section class="span3 sidebar secondary-column" id="secondary-nav" itemscope itemtype="http://schema.org/SiteNavigationElement"> <aside class="widget"> <ul class="navigation nocontent"> <li><a href="/ictr/i-need-/">I Need ...</a></li><li><a href="/ictr/about-umb-ictr/">About UMB ICTR</a> <ul class="multilevel-linkul-0"> <li><a href="/ictr/about-umb-ictr/ictr-leadership/">ICTR Leadership</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/about-umb-ictr/ictr-leadership/welcome-new-ictr-core-leadership/">Welcome New ICTR Core Leadership!</a></li> </ul> </li> <li><a href="/ictr/about-umb-ictr/ctsa/">CTSA</a></li> <li><a href="/ictr/about-umb-ictr/ictr-news-archive/">ICTR News Archive</a></li> </ul> </li><li><a href="/ictr/for-the-community/">For the Community</a> <ul class="multilevel-linkul-0"> <li><a href="/ictr/for-the-community/frequently-asked-questions-about-research/">Frequently Asked Questions About Research</a></li> <li><a href="/ictr/for-the-community/find-a-research-study/">Find a Research Study</a></li> <li><a href="/ictr/for-the-community/umb-community-engagement-highlights-/">UMB Community Engagement Highlights </a></li> <li><a href="/ictr/for-the-community/school-of-dentistry-sod/">School of Dentistry (SOD)</a></li> <li><a href="/ictr/for-the-community/school-of-social-work-ssw/">School of Social Work (SSW)</a></li> <li><a href="/ictr/for-the-community/school-of-pharmacy-sop/">School of Pharmacy (SOP)</a></li> <li><a href="/ictr/for-the-community/school-of-nursing-son/">School of Nursing (SON)</a></li> <li><a href="/ictr/for-the-community/school-of-medicine-som/">School of Medicine (SOM)</a></li> <li><a href="/ictr/for-the-community/francis-king-carey-school-of-law/">Francis King Carey School of Law</a></li> </ul> </li><li><a href="/ictr/investigator-resources/">Investigator Resources</a> <ul class="multilevel-linkul-0"> <li><a href="/ictr/investigator-resources/ictr-biostatistics-core-services/">ICTR Biostatistics Core Services</a></li> <li><a href="/ictr/investigator-resources/ictr-community-and-collaboration-core-services-/">ICTR Community and Collaboration Core Services </a></li> <li><a href="/ictr/investigator-resources/ictr-dissemination-and-implementation-core/">ICTR Dissemination and Implementation Core</a></li> <li><a href="/ictr/investigator-resources/ictr-drug-discovery-and-development-core/">ICTR Drug Discovery and Development Core</a></li> <li><a href="/ictr/investigator-resources/ictr-informatics-core-services/">ICTR Informatics Core Services</a></li> <li><a href="/ictr/investigator-resources/ictr-research-ethics-advisory-core/">ICTR Research Ethics Advisory Core</a></li> <li><a href="/ictr/investigator-resources/ictr-studios-consult-services/">ICTR Studios Consult Services</a></li> <li><a href="/ictr/investigator-resources/ictr-research-navigator/">ICTR Research Navigator</a></li> <li><a href="/ictr/investigator-resources/cibr-and-other-campus-core-services/">CIBR and Other Campus Core Services</a></li> <li><a href="/ictr/investigator-resources/clinical-research-resources/">Clinical Research Resources</a></li> <li><a href="/ictr/investigator-resources/data-and-data-handling/">Data and Data Handling</a></li> <li><a href="/ictr/investigator-resources/participant-recruitment-/">Participant Recruitment </a></li> <li><a href="/ictr/investigator-resources/research-compliance-training-and-tools-/">Research Compliance, Training, and Tools </a></li> <li><a href="/ictr/investigator-resources/research-proposal-development-and-review-/">Research Proposal Development and Review </a></li> <li><a href="/ictr/investigator-resources/specimen-handling-transporting-and-storage-/">Specimen Handling, Transporting, and Storage </a></li> <li><a href="/ictr/investigator-resources/statistical-software/">Statistical Software</a></li> <li><a href="/ictr/investigator-resources/ictr-supporting-documents-for-a-grant-application/">ICTR Supporting Documents for a Grant Application</a></li> </ul> </li><li><a href="/ictr/funding/">Funding</a> <ul class="multilevel-linkul-0"> <li><a href="/ictr/funding/ictr-pilot-grant-awardee-news/">ICTR Pilot Grant Awardee News</a></li> <li><a href="/ictr/funding/atip-grant-program-foa/">ATIP Grant Program FOA</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/funding/atip-grant-program-foa/faqs/">FAQs</a></li> </ul> </li> <li><a href="/ictr/funding/community-engaged-research-cenr-pilot-grant/">Community Engaged Research (CEnR) Pilot Grant</a></li> <li><a href="/ictr/funding/community-engaged-research-cenr-partnership-development/">Community Engaged Research (CEnR) Partnership Development</a></li> <li><a href="/ictr/funding/voucher-program/">Voucher Program</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/funding/voucher-program/voucher-program---cenr/">Voucher Program - CEnR</a></li> </ul> </li> <li><a href="/ictr/funding/ctsa-program-collaborative-innovation-awards/">CTSA Program Collaborative Innovation Awards</a></li> <li><a href="/ictr/funding/internal-funding-highlights/">Internal Funding Highlights</a></li> </ul> </li><li><a href="/ictr/education-and-training/">Education and Training</a> <ul class="multilevel-linkul-0"> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/">ICTR Training and Career Development Core</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/umb-ictr-tl1---predoctoral---clinical-research-training-awards/">UMB ICTR TL1 - Predoctoral - Clinical Research Training Awards</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/umb-ictr-tl1---postdoctoral---clinical-research-training-awards/">UMB ICTR TL1 - Postdoctoral - Clinical Research Training Awards</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/umb-ictrctsa-k12-mentored-career-development-award/">UMB ICTR/CTSA K12 Mentored Career Development Award</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/">ICTR Training and Career Development News</a> <ul class="multilevel-linkul-2"> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-2024-ictr-scholar-awardees/">Congratulations 2024 ICTR Scholar Awardees!</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-nephrotic-syndrome-kl2-mentored-career-development-awardee/">Congratulations Nephrotic Syndrome KL2 Mentored Career Development Awardee!</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-2023-ictr-scholar-awardees/">Congratulations 2023 ICTR Scholar Awardees!</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-2022-ictr-scholar-awardees/">Congratulations 2022 ICTR Scholar Awardees!</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-2021-ictr-scholar-awardees/">Congratulations 2021 ICTR Scholar Awardees!</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/umb-kl2-scholars-forging-ahead-during-healthcare-crises/">UMB KL2 Scholars Forging Ahead During Healthcare Crises</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/congratulations-2020-ictr-scholar-awardees/">Congratulations 2020 ICTR Scholar Awardees</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/2019-ictr-kl2-and-tl1-scholars-/">2019 ICTR KL2 and TL1 Scholars </a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/first-umb-ctsa-kl2-awardee-announced/">First UMB CTSA KL2 Awardee Announced</a></li> <li><a href="/ictr/education-and-training/ictr-training-and-career-development-core/ictr-training-and-career-development-news/ictr-2018---2019-scholars-program/">ICTR 2018 - 2019 Scholars Program</a></li> </ul> </li> </ul> </li> <li><a href="/ictr/education-and-training/nephrotic-syndrome-kl2-career-development-award/">Nephrotic Syndrome KL2 Career Development Award</a></li> <li><a href="/ictr/education-and-training/umb-campus-training-and-career-development-programs/">UMB Campus Training and Career Development Programs</a></li> <li><a href="/ictr/education-and-training/ictr-enrichment-series/">ICTR Enrichment Series</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/education-and-training/ictr-enrichment-series/ictr-enrichment-series-recordings/">ICTR Enrichment Series Recordings</a></li> </ul> </li> <li><a href="/ictr/education-and-training/ictr-co-sponsored-lectures-and-events/">ICTR Co-Sponsored Lectures and Events</a> <ul class="multilevel-linkul-1"> <li><a href="/ictr/education-and-training/ictr-co-sponsored-lectures-and-events/ictr-co-sponsored-event-recordings/">ICTR Co-Sponsored Event Recordings</a></li> </ul> </li> </ul> </li><li><a href="/ictr/acknowledging-umb-ictr/">Acknowledging UMB ICTR</a></li><li><a href="/ictr/archived-content/">Archived Content</a></li> </ul> </aside>   </section>  <div class="span9 primary-column" itemprop="mainContentOfPage">   <div class="row-fluid content_title"> <div class="span12"> <h2> <span> ICTR Drug Discovery and Development Core </span> </h2> </div> </div>  <meta itemprop="name" content="ICTR Drug Discovery and Development Core" /> <meta itemprop="description" content="ICTR Drug Discovery and Development Resources " />  <div class="umb-btn-menu-19 btn-menu-19-yellow umb-btn-menu-fullwidth"> <a href="http://eepurl.com/iQu-Yw" target="_blank" > SUBSCRIBE TO THE ICTR EMAIL LIST for the latest ICTR announcements. </a> </div> <span id="d.en.439103"></span><div class="row-fluid general_content"> <div class="span12"> <div class="one-column-content"> <p class="umb_lead">With the Drug Discovery and Development (DDD) Core bring your most promising new therapeutics out of the laboratory and into the clinic at an accelerated pace. </p> <p class="umb_lead">To apply, see <strong><em>How to Apply...</em> </strong>below</p> <p class="umb_lead"> </p> </div></div> </div><span id="d.en.440325"></span> <div class="row-fluid general_content"> <h3 class="short_headline"> Faculty can request up to 25 hours* of free services from each of the following areas: </h3> </div><script type="text/javascript"> $(document).ready(function() { $('.A440317').slideUp(0); var open440317 = false; $('.Q440317').click( function() { $('.A440317').slideToggle(); if (open440317 == false) { $(".Arrow440317").text(""); open440317 = true; $('.Q440317').addClass("open"); } else { $(".Arrow440317").text("▾"); open440317 = false; $('.Q440317').removeClass("open"); } }); }); </script> <span id="d.en.440317"></span><div class="row-fluid general_content"> <div class="span12 q_a"> <p><a class='Q440317 q_a_question'>Computer-Aided Drug Design <span class='Arrow440317'>▾</span></a><br /> </p> <span class='A440317 q_a_answer'><div class="span12"><p>Directed by <strong><a href="https://www.pharmacy.umaryland.edu/centers/computer-aided-drug-design-cadd-center/" target="_blank">Dr. Alexander MacKerell</a></strong>, the UMB <strong><a href="https://www.pharmacy.umaryland.edu/centers/computer-aided-drug-design-cadd-center/" target="_blank">Computer-Aided Drug Design (CADD) Center</a></strong> provides custom services in the areas of rational drug discovery and optimization and macromolecular modeling, including proteins, DNA, RNA, carbohydrates, and lipids. Specific capabilities include in silico database screening, lead compound optimization and rational formulation of biologics using the site-identification by ligand saturation (SILCS) approach. Macromolecular modeling capabilities include homology modeling and molecular dynamic simulations including enhanced sampling technologies. The CADD center will offer all UMB campus faculty access to up to <strong>25 hours of free</strong> research-related consultation, including interactive computer access, and <strong>2,500 CPU hours</strong> of batch computational resources including access to CADD computational software and <em>in silico</em> databases.</p></div></span> </div> </div><script type="text/javascript"> $(document).ready(function() { $('.A440320').slideUp(0); var open440320 = false; $('.Q440320').click( function() { $('.A440320').slideToggle(); if (open440320 == false) { $(".Arrow440320").text(""); open440320 = true; $('.Q440320').addClass("open"); } else { $(".Arrow440320").text("▾"); open440320 = false; $('.Q440320').removeClass("open"); } }); }); </script> <span id="d.en.440320"></span><div class="row-fluid general_content"> <div class="span12 q_a"> <p><a class='Q440320 q_a_question'>Clinical Pharmacology and Pharmacometrics  <span class='Arrow440320'>▾</span></a><br /> </p> <span class='A440320 q_a_answer'><div class="span12"><p>Directed by <strong><a href="https://www.pharmacy.umaryland.edu/centers/ctm/people/biographies/" target="_blank"><span style="text-decoration: underline;">Dr.</span> Joga Gobburu</a></strong>, the<strong> <a href="https://www.pharmacy.umaryland.edu/centers/ctm/" target="_blank">Center for Translational Medicine (CTM)</a></strong> offers clinical pharmacology and pharmacometrics services to support drug development and regulatory submissions. </p> <p><strong>Pharmacokinetic (PK) Analysis and Reporting</strong></p> <ul> <li>Non-compartmental PK data analysis for single-, multiple-ascending dose, drug-drug interaction, food effect, bioequivalence, bioavailability, Physiologically based pharmacokinetic (PBPK) modeling and special population studies</li> </ul> <p><strong>Population Pharmacokinetic-pharmacodynamic (PK/PD) & Exposure-Response Analyses and Reporting</strong></p> <ul> <li>Population pharmacokinetic-pharmacodynamic (PK/PD) analysis, exposure-response modeling, and simulation for effectiveness and safety endpoint</li> <li>Special expertise in pediatric and QT trial design and analysis</li> </ul> <p><strong>Disease Modeling and Trial Design</strong></p> <ul> <li>Quantitative disease-drug-trial models to support internal company and regulatory decisions</li> <li>Comparative effectiveness, clinical trial simulations, projecting net drug effect, understanding trial failures, and asset valuation, design and analysis of adaptive, enrichment, and dose-response trials</li> </ul> <p>The CTM will offer all UMB campus faculty access to up to <strong>25 hours of free</strong> research-related consultation on topics related to PK,PD, PKPD modeling, experimental and clinical trial design, and drug development.</p></div></span> </div> </div><script type="text/javascript"> $(document).ready(function() { $('.A440321').slideUp(0); var open440321 = false; $('.Q440321').click( function() { $('.A440321').slideToggle(); if (open440321 == false) { $(".Arrow440321").text(""); open440321 = true; $('.Q440321').addClass("open"); } else { $(".Arrow440321").text("▾"); open440321 = false; $('.Q440321').removeClass("open"); } }); }); </script> <span id="d.en.440321"></span><div class="row-fluid general_content"> <div class="span12 q_a"> <p><a class='Q440321 q_a_question'>Mass Spectrometry Center (MSC) <span class='Arrow440321'>▾</span></a><br /> </p> <span class='A440321 q_a_answer'><div class="span12"><p>Directed by <strong><a href="https://www.pharmacy.umaryland.edu/centers/massspec/contact/" target="_blank" rel="noopener">Dr. Maureen Kane</a></strong>, the <strong><a href="https://www.pharmacy.umaryland.edu/centers/massspec/" target="_blank" rel="noopener">Mass Spectrometry Center (MSC)</a></strong> provides state of the art analysis in various advanced protein analysis techniques including comparative proteomic expression analysis, post-translational modification analysis, protein interaction (interactome) analysis as well as a number of other custom proteomic analysis capabilities. The MSC also provides a host of other mass spectrometry-based techniques including quantitative LC-MS/MS, targeted metabolomics, lipidomics, and mass spectrometry imaging. </p> <p>The MSC will offer a free consultation and subsidized proteomic studies of up to 12 samples* where the person time and 5% of the hourly instrument use charges will be subsidized**. Experiments for other analysis techniques may also be possible up to the <strong>25 ICTR-supported hours of service</strong>, but require an ICTR Resource Request submission and consultation to determine scope and feasibility. For experiments requiring specialized reagents, reagents will be charged at cost. </p> <p><em>*actual study size depends on types of samples/scope of analysis to be determined in consultation</em></p> <p><em>**subsidy rate is evaluated periodically and subject to change</em></p> <p><strong> The MSC offers expertise and applications in the following research areas: </strong></p> <ul> <li> <p>Metabolomics</p> </li> <li> <p>Lipidomics</p> </li> <li> <p>Proteomics</p> </li> <li> <p>Quantitative Analysis of Metal Ions in Biological Systems and Materials; Metallomics</p> </li> <li> <p>LC-MS/MS assay development</p> </li> <li> <p>Drug analysis and PK/PD</p> </li> <li> <p>GLP regulated bioanalysis for clinical studies</p> </li> <li> <p>Chemical compound identification and structure elucidation</p> </li> <li> <p>Biomarker identification and characterization</p> </li> <li> <p>Mass Spectrometry Imaging (MSI)</p> </li> <li> <p>Hydrogen Deuterium Exchange Mass Spectrometry (HDX)</p> </li> <li> <p>Fast Photochemical Oxidation of Proteins (FPOP)</p> </li> <li> <p>Bioinformatics and Cheminformatics</p> </li> </ul></div></span> </div> </div><script type="text/javascript"> $(document).ready(function() { $('.A440322').slideUp(0); var open440322 = false; $('.Q440322').click( function() { $('.A440322').slideToggle(); if (open440322 == false) { $(".Arrow440322").text(""); open440322 = true; $('.Q440322').addClass("open"); } else { $(".Arrow440322").text("▾"); open440322 = false; $('.Q440322').removeClass("open"); } }); }); </script> <span id="d.en.440322"></span><div class="row-fluid general_content"> <div class="span12 q_a"> <p><a class='Q440322 q_a_question'>Drug Formulation Laboratory <span class='Arrow440322'>▾</span></a><br /> </p> <span class='A440322 q_a_answer'><div class="span12"><p>Directed by <strong><a href="https://www.pharmacy.umaryland.edu/facilities/applied-pharmaceutics-lab-aphl/contact/" target="_blank">Dr. Stephen Hoag</a></strong>, the Drug Formulation Laboratory - also known as the <strong><a href="https://www.pharmacy.umaryland.edu/facilities/applied-pharmaceutics-lab-aphl/" target="_blank">Applied Pharmaceutics Laboratory (APhL)</a></strong> - has fully-equipped modern research laboratories for pre-formulation and formulation production. The APhL can develop custom dosage forms and matching placebos for research, animal testing and human clinical trials: Dosage forms can be immediate, enteric and controlled release. The APhL also conducts studies needed for the Chemistry, Manufacturing and Control (CMC) section of an Investigational New Drug (IND) application and helps prepare regulatory filings to the U.S. Food and Drug Administration (FDA).</p></div></span> </div> </div><span id="d.en.440323"></span> <div class="row-fluid general_content"> <div class="span8"> <h3 class="short_headline">How to Apply for ICTR Resources</h3> <p>For<strong> UMB faculty</strong>, use your UMID to log in to the  <strong><a href="/ictr/funding/ictr-core-service-request/" target="_blank">ICTR Resource Request </a></strong>webpage to access the link to the application (developed in <strong><em>REDCap</em></strong>).   </p> <p>For <strong>UMBC, UMCP, and JHU faculty</strong>, please use this link to request an application <strong><a href="https://rs.igs.umaryland.edu/surveys/?s=HDNFLEWNR9HPEYP7" target="_blank" rel="noopener">https://rs.igs.umaryland.edu/surveys/?s=HDNFLEWNR9HPEYP7</a></strong></p> <p><strong>PLEASE NOTE!  You must be ready to use any service you select on the request form.  Services cannot be encumbered for future use. </strong></p> <p><strong>For questions, please email ICTR-Navigator@umaryland.edu.</strong></p> </div> <div class="span4 quicklinks"> <h5>ICTR DDD Core Leadership</h5> <ul> <li><a href="https://www.pharmacy.umaryland.edu/facilities/cpu/faculty/" target="_blank" rel="noopener">James Polli, PhD, Director</a></li> <li><a href="https://www.pharmacy.umaryland.edu/centers/ctm/people/biographies/" target="_blank" rel="noopener">Joga Gobburu, PhD, MBA, Associate Director</a></li> <li><a href="https://www.pharmacy.umaryland.edu/facilities/applied-pharmaceutics-lab-aphl/contact/" target="_blank" rel="noopener">Stephen Hoag, PhD, Associate Director</a></li> <li><a href="https://www.pharmacy.umaryland.edu/centers/massspec/contact/" target="_blank" rel="noopener">Maureen Kane, PhD Associate Director</a></li> <li><a href="https://www.pharmacy.umaryland.edu/centers/computer-aided-drug-design-cadd-center/" target="_blank" rel="noopener">Alexander MacKerell, PhD, Associate Director</a></li> <li><a href="https://www.pharmacy.umaryland.edu/about/depts/psc/faculty/" target="_blank" rel="noopener">Paul Shapiro, PhD, Associate Director</a></li> </ul> </div> </div> </div> </div> </div> <div id="footer-for-print" style="display:none;"><p>The University of Maryland, Baltimore is the founding campus of the University System of Maryland. <br /> 620 W. Lexington St., Baltimore, MD 21201 | 410-706-3100 <br />© 2023-2024 University of Maryland, Baltimore. All rights reserved.</p> </div> </div>  </div> <span class="backToTop"><a href="#top">back to top</a></span> <footer id="footer" class="clearfix ictr-custom-footer"> <div class="container"> <div class="row-fluid"> <div class="span8 footerlinkbox about-ictr-footer"> <h4>OUR MISSION</h4> <p class="umb_lead">The mission of the UMB ICTR is to remove barriers to clinical and translational research by providing high-quality, cost-effective informatics, biostatistics, clinical resources, mentorship, and other core services that will support clinical research, community engagement, ethics and regulatory science, pilot projects, and the development of novel technologies.</p> <p><a class="umb_pillbutton" href="/ictr/about-umb-ictr/">Learn More</a></p> </div> <div class="span4" > <p><a href="/ictr/about-umb-ictr/ctsa/"><strong>UMB</strong> collaborates with <strong>JHU</strong> for the prestigious <strong>National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA)</strong></a></p> <p> </p> <p class="no-link-icon"> <a href="https://www.umaryland.edu/" target="_blank"><img src="/media/umb/ictr/web-template-style-assets/UMB-logo_horizontal_white-notastiny.png" alt="The University of Maryland, Baltimore" ></a> </p> <p> </p> <p class="no-link-icon"> <a href="https://www.jhu.edu/" target="_blank"><img src="/media/umb/ictr/web-template-style-assets/JHU-Logo.png" alt="Johns Hopkins University" ></a> </p> <p> </p> </div>  </div>  <div class="row-fluid"> <div class="span8 footerlinkbox-adjacent"> <p>The University of Maryland, Baltimore prohibits sex discrimination in any education program or activity that it operates. Individuals may report concerns or questions to the <a href="mailto:titleix@umaryland.edu">Title IX Coordinator</a>. Read the <a href="https://www.umaryland.edu/policies-and-procedures/library/administration/policies/vi-100c.php">UMB Notice of Non-Discrimination</a>.</p> </div> <div class="span4"> <div class="umb-social-icons no-link-icon"> <a href="https://www.linkedin.com/company/umb-ictr/" title="UMB LinkedIn" target="_blank"><img src="/media/umb/style-assets/images/social-media-icons/linkedin.png" alt="UMB ICTR LinkedIn" ></a> <a href="https://www.facebook.com/umbictr" title="UMB Facebook" target="_blank"><img src="/media/umb/style-assets/images/social-media-icons/fb-w.png" alt="UMB ICTR Facebook" ></a> <a href="https://www.instagram.com/umbictr/" title="UMB Instagram" target="_blank"><img src="/media/umb/style-assets/images/social-media-icons/instagram-w.png" alt="UMB ICTR Instagram" ></a> <a href="https://twitter.com/UMBICTR" title="UMB X" target="_blank"><img src="/media/umb/style-assets/images/social-media-icons/twitter-w.png" alt="UMB ICTR X" ></a> </div> </div>  </div>  </div>   <section class="footerCredits"> <div class="container"> <ul class="clearfix"> <li><a class="t4Edit-page" href="https://sitemanager.umaryland.edu/terminalfour/page/directEdit#edit/11/en/124086">©</a> 2023-2024 University of Maryland, Baltimore. All rights reserved.</li> <li><a href="/site-map/">Site Map</a></li> <li><a href="/policies-and-procedures/library/information-technology/policies/x-9915a.php">Privacy</a></li> <li><a href="/web-accessibility/">Accessibility</a></li> <li><a href="/cpa/web-feedback/">Web Feedback</a></li> <li><a href="/policies-and-procedures/library/administration/policies/vi-100c.php">Non-Discrimination</a></li> </ul> </div>  </section>  </footer>      <script src="/media/umb/style-assets/javascript/custom.js"></script> <script src="/media/umb/style-assets/javascript/index_slider.js"></script>  <script> var ie8orbelow = false; </script>   <script src="/media/umb/style-assets/javascript/misc_scripts.js"></script>  <script src="/media/umb/style-assets/javascript/search.js"></script>  <script type="text/javascript"> /*<![CDATA[*/ (function() { var sz = document.createElement('script'); sz.type = 'text/javascript'; sz.async = true; sz.src = '//siteimproveanalytics.com/js/siteanalyze_12634.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(sz, s); })(); /*]]>*/ </script> </body> </html>

CINXE.COM

ICTR Drug Discovery and Development Core - University of Maryland, Baltimore