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The American Journal of Surgical Pathology

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content="3" /><meta name="wkhealth_article_publication_date" content="September 26, 2019" /><meta name="wkhealth_volume" content="44" /><meta name="wkhealth_ovid_accession_number" content="00000478-202003000-00012" /><meta name="wkhealth_issn" content="0147-5185" /><meta name="wkhealth_title" content="Endometrial Gastric (Gastrointestinal)-type Mucinous Lesions: Report of a Series Illustrating the Spectrum of Benign and Malignant Lesions" /><meta name="wkhealth_authors" content="Wong, Richard Wing-Cheuk;Ralte, Angela;Grondin, Katherine;Talia, Karen L.;McCluggage, W. Glenn" /><meta name="wkhealth_doi" content="10.1097/PAS.0000000000001381" /><meta name="wkhealth_abstract_html_url" content="https://journals.lww.com/ajsp/abstract/2020/03000/endometrial_gastric__gastrointestinal__type.12.aspx" /><meta name="wkhealth_fulltext_html_url" content="https://journals.lww.com/ajsp/fulltext/2020/03000/endometrial_gastric__gastrointestinal__type.12.aspx" /><meta name="wkhealth_toc_section" content="Original Articles" /><meta name="wkhealth_toc_sub_section" /><meta name="wkhealth_eJpId" content="ajsp:2020:03000:00012" /><meta name="wkhealth_firstpage" content="406" /><meta name="wkhealth_date" content="March 2020" /><meta name="wkhealth_pdf_url" content="https://journals.lww.com/ajsp/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=Other&amp;an=00000478-202003000-00012" /><meta name="Description" content="With the recent elucidation of gastric-type lesions in the female genital tract (especially in the c" /><meta property="og:site_name" content="LWW" /><meta property="og:type" content="article" /><meta property="og:title" content="Endometrial Gastric (Gastrointestinal)-type Mucinous... : The American Journal of Surgical Pathology" /><meta property="og:description" content="y. We report 9 cases of endometrial mucinous lesions which exhibit gastric (gastrointestinal)-type features by morphology and immunohistochemistry, including 4 adenocarcinomas and 5 benign mucinous lesions, in patients aged 32 to 85. The adenocarcinomas showed gastric-type morphology in all 4 cases and goblet cells in 1, with a component of benign gastric-type mucinous glands in 1 case. Immunohistochemically, the adenocarcinomas were positive for CK7 (4/4), CEA (4/4), MUC6 (3/3), PAX8 (3/4), CK20 (2/4), CDX2 (2/4), and estrogen receptor (1/4). They were negative for Napsin A (0/3), with mutation-type p53 staining in 2/4 cases, block-type p16 positivity in 1/4, and scattered chromogranin-positive cells in 1/2. Targeted next-generation sequencing revealed nonsense mutation in RB1 gene for the case with block-positive p16. Follow-up was available in all adenocarcinoma cases and indicated aggressive behavior; 2 patients were dead of disease at follow-up of 7 months to 3 years, 1 was alive with progression at 9 months, and 1 was alive without disease at 7 months. The benign mucinous lesions (including the benign component in 1 adenocarcinoma) exhibited gastric-type morphologic features in 5/6 cases, goblet cells in 5/6, and Paneth-like neuroendocrine cells in 1/6. These benign mucinous lesions were associated with an endometrial polyp in 5/6 cases. Cytologic atypia was present in 2/6 cases and a lobular architecture resembling cervical lobular endocervical glandular hyperplasia in 4/6. Immunohistochemically, the benign mucinous lesions were positive for CK7 (5/5), CDX2 (5/6), estrogen receptor (4/5), MUC6 (4/5), CK20 (3/5), PAX8 (3/5), and CEA (2/4), with scattered chromogranin-positive cells in 4/4 cases; in all cases tested Napsin A was negative, p53 was wild-type and p16 was negative. We propose the term “endometrial gastric (gastrointestinal)-type adenocarcinoma” for this distinctive group of rare aggressive endometrial carcinomas. We believe that benign or atypical gastric (gastrointestinal)-type mucinous lesions are putative precursors for these adenocarcinomas, comparable to recognized premalignant gastric-type lesions in the cervix and the vagina. Future recognition and reporting of these gastric-type endometrial mucinous lesions will help delineate their pathogenesis and clinical significance...." /><meta property="og:image" content="https://images.journals.lww.com/ajsp/SocialThumb.00000478-202003000-00012.T1.jpeg" /><meta property="og:image:width" content="1416" /><meta property="og:image:height" content="1247" /><meta property="og:url" content="https://journals.lww.com/ajsp/fulltext/2020/03000/endometrial_gastric__gastrointestinal__type.12.aspx" /><meta property="twitter:card" content="summary" /><meta name="robots" content="index, follow, noarchive" /><meta name="WT.sv" content="ZUSE1PEJPWEB03" /><meta name="Title" content="The American Journal of Surgical Pathology" /><style id="SPThemeHideForms" type="text/css">body {opacity:0 !important}</style> <!-- Head container delegate control --> <link 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}function getEmailTOColleaguePopupID() { return "ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_emailToColleague"; }function image(id, nextImageId, previousImageId, title, description, rolloverUrl, popupUrl, fullSizeUrl, originalUrl, imageGalleryUrl, windowId){this.id = id;this.title = title;this.description = description;this.rolloverUrl = rolloverUrl;this.popupUrl = popupUrl;this.nextImageId = nextImageId;this.previousImageId = previousImageId; this.fullsizeUrl = fullSizeUrl; this.originalUrl = originalUrl;this.imageGalleryUrl = imageGalleryUrl; this.windowId=windowId}function Global_GetImagesCollection(){var images = new Object();images["T1"]=new image("T1","T2","","TABLE 1","Clinical Features of Endometrial Gastric (Gastrointestinal)-type Adenocarcinomas and Benign Mucinous Lesions","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.T1.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.T1.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=T1&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.T1.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_T1");images["T2"]=new image("T2","F1","T1","TABLE 2","Pathologic Features of Endometrial Gastric (Gastrointestinal)-type Adenocarcinomas","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.T2.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.T2.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=T2&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.T2.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_T2");images["F1"]=new image("F1","F2","T2","FIGURE 1","Histologic features of endometrial adenocarcinomas exhibiting gastric (gastrointestinal)-type differentiation. The adenocarcinomas exhibit a confluent glandular and papillary architecture (A, B). Case exhibiting myometrial invasion (C). Gastric-type morphologic features with pale eosinophilic to clear cytoplasm with distinct cell borders are present (D, E). Case exhibiting myometrial invasion and necrosis (F).","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.F1.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.F1.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=F1&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.F1.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_F1");images["F2"]=new image("F2","T3","F1","FIGURE 2","Histologic and immunohistochemical features of gastric-type adenocarcinoma with component of benign mucinous glands in case 1. Neoplastic glands exhibiting enlarged hyperchromatic nuclei coexist with benign mucinous glands which resemble gastric pyloric glands (A, B). Immunohistochemistry shows MUC6 positivity in both malignant and benign elements (C). The adenocarcinoma (left) shows diffuse mutation-type positivity for p53 while the benign glands (right) show a wild-type pattern (D). ER is completely negative in the adenocarcinoma (left) but focally positive in the benign mucinous glands (right) (E); similarly PAX8 is focally weakly positive in the adenocarcinoma (left) but diffusely positive in the benign mucinous glands (right) (F).","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.F2.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.F2.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=F2&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.F2.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_F2");images["T3"]=new image("T3","F3","F2","TABLE 3","Pathologic Features of Benign Gastric (Gastrointestinal)-type Mucinous Lesions of the Endometrium","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.T3.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.T3.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=T3&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.T3.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_T3");images["F3"]=new image("F3","T4","T3","FIGURE 3","Histologic features of benign gastric (gastrointestinal)-type mucinous lesions of the endometrium. Mucinous glands and atrophic endometrial glands are present (A). Goblet cells (B) and pale eosinophilic cytoplasm typical of gastric-type mucinous lesions (C) are commonly found. Focal nuclear enlargement and hyperchromasia qualifying as cytologic atypia may be present (D). Mild glandular crowding (E) and lobular architecture resembling cervical LEGH (F) are present in some cases.","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.F3.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.F3.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=F3&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.F3.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_F3");images["T4"]=new image("T4","F4","F3","TABLE 4","Immunohistochemical Findings in Endometrial Gastric (Gastrointestinal)-type Adenocarcinomas and Benign Mucinous Lesions","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.T4.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.T4.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=T4&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.T4.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_T4");images["F4"]=new image("F4","F5","T4","FIGURE 4","Immunohistochemical findings in endometrial gastric-type adenocarcinomas. In case 2, the adenocarcinoma shows diffuse positive staining for MUC6 (A), as well as block-type positivity for p16 (B) and wild-type expression of p53 (C). Focal expression of the enteric markers CDX2 (D) and CK20 (E) is observed in case 1, which also features scattered chromogranin-positive cells (F).","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.F4.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.F4.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=F4&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.F4.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_F4");images["F5"]=new image("F5","T5","F4","FIGURE 5","Immunohistochemical findings in benign gastric (gastrointestinal)-type mucinous lesion of the endometrium (case 5). The mucinous glands are focally positive for MUC6 (A), with goblet cells highlighted by CK20 (arrows) (B), while ER is focally positive (C) and PAX8 is diffusely positive (D). Scattered chromogranin-positive cells are present (arrowheads) (E), as well as focal CDX2 positivity (F).","https://images.journals.lww.com/ajsp/Rollover.00000478-202003000-00012.F5.jpeg","https://images.journals.lww.com/ajsp/Gallery.00000478-202003000-00012.F5.jpeg","https://journals.lww.com/ajsp/_layouts/oaks.journals/ImageView.aspx?k=ajsp:2020:03000:00012&i=F5&year=2020&issue=03000&article=00012&type=Abstract","https://images.journals.lww.com/ajsp/Original.00000478-202003000-00012.F5.jpeg","/ajsp/pages/imagegallery.aspx?year=2020&issue=03000&article=00012", "ajsp_2020_03000_00012_F5");images["T5"]=new image("T5","","F5","TABLE 5","Proposed Diagnostic Criteria and Terminology for Endometrial Gastric (Gastrointestinal)-type Mucinous 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aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <p> <span id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage"></span> </p> <div class="wk-button-bar"> <div class="wk-button-group-left"> <p id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons" Style="display: none;"> <input type="submit" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue" value="Yes" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_btnContinue" class="primary-button" /> <input type="button" value="No" id="btnCancel" aria-label="close dialog" class="js-close secondary-button" /> </p> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> <div id="ej-clear-float"> </div> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnSubscribeAlertType" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeJournalId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeMessage" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenTopicalCollectionId" 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document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') { document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId; } if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Root(title, journalId, alertType) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = alertType; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Citation(title, journalId, ovidId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Citation'; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId').value = ovidId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCPopup_Topical(title, journalId, topicalCollectionId) { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage'); lblUnsubscribeMessage.innerHTML = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Topical'; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId; document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId').value = topicalCollectionId; $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show(); if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') { document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId; } if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } function alerts_ShowUnSubscribeeTOCSuccessPopup() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.show(); } } $('.js-close').on('click', function() { var unSubscribeeTocPopup = $find('unSubscribeToAlerts'); if (unSubscribeeTocPopup != null) { unSubscribeeTocPopup.hide(); } return false; }); </script> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl"></span> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscribeToEtocPopupState" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState" value="showemail" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenConfirmSubscriptionPageUrl" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId" /> <input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscriptionType" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType" /> <div id="divPopupOverLay" class="Popup-Overlay" style="display: none; position: fixed; left: 0; top: 0; z-index: 3800; width: 1920px; height: 4517px;"></div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc" class="etoc-popup ej-box-modal-drop-shadow" style="display: none;"> <div tabindex="-1" role="dialog" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal"> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain" onkeypress="javascript:return WebForm_FireDefaultButton(event, &#39;ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue&#39;)"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblTitle"></span> </div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "> <i class="fa fa-times"></i> </button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <div class="wk-field-body"> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage"></span></strong> </div> <div class="wk-field-body"> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError" style="color:Black;display:none;"> <div class="ej-error-message"> <p class="ej-error-message-icon error-red"> </p> </div> </span> <label for="Email input">Enter your Email address:</label> <div class="wk-field-body"> <input name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$txtEmailAddress" type="text" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress" class="ej-box-modal-style-1-input" /> </div> </div> <div class="wk-button-bar"> <div class="wk-button-group-left"> <input type="submit" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue" value="Continue" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue" class="primary-button" /> <input type="button" value="Cancel" id="btnCancel" class="js-close secondary-button" /> </div> </div> </div> <div class="wk-field-item"> <div class="wk-field-body"> <a id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hypPrivacy" href="https://journals.lww.com/ajsp/_layouts/oaks.journals/privacy.aspx" target="_blank">Privacy Policy</a> </div> </div> </div> </section> </div> <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser" style="display: none;"> <section class="wk-modal-content"> <header class="wk-modal-header ejp-modal-header"> <div class="wk-modal-title ejp-modal-title"></div> <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button> </header> <div class="wk-modal-body"> <div class="wk-field-item"> <p> <strong> <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle"></span> </strong> </p> </div> <p id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pAuthenticatedUserMessage"> </p> </div> </section> </div> </div> </div> <div id="ej-clear-float"> </div> <script type="text/javascript"> function alerts_SaveSubscriptionTypeInHiddenField(url, subscriptionType, journalId, yearId, issueId, articleId) { if (journalId && yearId && issueId && articleId) { logCounterDataAlertWhenCitedSynchronously(journalId, yearId, issueId, articleId); } $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType); $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').val(journalId); if (url) window.location = url; else __doPostBack('hypSubscribeToAlerts'); return false; } function alerts_ShowSubscribeeTOCPopup(journalTitle, journalId, subscriptionType, displaySubscriptionType) { $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType); var subscribeToEtocPopup = $find('subscribeToEtoc'); subscribeToEtocPopup.show(); document.getElementsByTagName( 'html' )[0].classList.add('no-scroll'); var modelPopupState = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState'); var emailTextBox = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress'); var thanksPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser'); var mainPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain'); var thankYouMessageUnAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage'); var thankYouMessageAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle'); if (!displaySubscriptionType) { displaySubscriptionType = subscriptionType; } if (modelPopupState.value == 'showthanksmessage') { thanksPanel.style.display = "block"; mainPanel.style.display = "none"; thankYouMessageAuthenticated.innerHTML = "Thank you for subscribing to the " + displaySubscriptionType + " for " + journalTitle + "."; } if (modelPopupState.value == 'showemail') { thanksPanel.style.display = "none"; mainPanel.style.display = "block"; thankYouMessageUnAuthenticated.innerHTML = "Thank you for choosing to subscribe to the " + displaySubscriptionType + " for " + journalTitle + "."; } if ($('.etoc-popup') != null) { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').value = journalId; if (modelPopupState.value == 'showemail') emailTextBox.focus(); } } $('.js-close').on('click', function () { document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress').value = ""; document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').style.display = "none"; var pageUrl = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl'); var subscribeeTocPopup = $find('subscribeToEtoc'); if (subscribeeTocPopup != null) { subscribeeTocPopup.hide(); document.getElementsByTagName( 'html' )[0].classList.remove('no-scroll'); if (pageUrl.value !== '' && pageUrl.value !== window.location.pathname) window.location = pageUrl.value; } return false; }); </script> <div id="ctl00_ctl51_Header_UserActionTools_eTocTopContainer"> <div id="eTocTop" style="display: none;"> <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup(&#39;The American Journal of Surgical Pathology&#39;,&#39;ajsp&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);;" onclick="javascript: alerts_ShowSubscribeeTOCPopup(&#39;The American Journal of Surgical Pathology&#39;,&#39;ajsp&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);"><span id="ctl00_ctl51_Header_UserActionTools_alertLinkControlTop_defaultText" class="hideOnFixed">Subscribe to eTOC</span></a> </div> </div> <script> $(function () { //find recent searches link and move container var recentSearchesControl = $("a[id$='RecentSearches']"); if (recentSearchesControl.length) { recentSearchesControl.click(function (e) { e.stopPropagation(); if ($("#ResentSearchContainer").is(":hidden")) { $("#ResentSearchContainer").slideDown("slow"); recentSearchesControl.addClass('open'); } else { $("#ResentSearchContainer").hide(); recentSearchesControl.removeClass('open'); } }); } var eTocAccountLink = $("ul.js-user-action-toolbar__dropdown>li>a[id='SubscribeToEToc']"); if (eTocAccountLink.length) { eTocAccountLink.parent().html($("#eTocTop>a")); } }); </script> <a class="logo-secondary white" href="http://wolterskluwer.com/" target="_blank"> <h3 class="logo-secondary-text">Secondary Logo</h3> </a> <a href="#" class="sticky-search"><i class="fa fa-search"></i></a> </div> <div class="header__layout-bottom wk-grid-page-container"> <a id="hypJournals" class="logo-main" href="https://journals.lww.com/ajsp/pages/default.aspx"> <h3 class="logo-main-text">Journal Logo </h3> </a> <div class="search-v2"> <div class="search-wrapper"> <select name="ctl00$ctl51$Header$SearchTopBoxControl$ddlContentScope" id="ctl00_ctl51_Header_SearchTopBoxControl_ddlContentScope"> <option value="All">All</option> <option selected="selected" value="Articles">Articles</option> <option value="Images">Images</option> <option value="Videos">Videos</option> <option value="Podcasts">Podcasts</option> <option value="Blogs">Blogs</option> </select> <div class="input-group" id="globalSearch"> <input name="ctl00$ctl51$Header$SearchTopBoxControl$txtKeywords" type="text" value="Search" id="ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords" class="form-control searchText" /> <span class="input-group-btn"> <button id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier" type="submit" class="btn btn-default"><i class="fa fa-search"></i></button> </span> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$IsAutoCompleteEnabled" id="ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled" value="true" /> <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$AutocompleteApiUrl" id="ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl" value="https://platformservices.wolterskluwerhealth.com/autocomplete/AJSP/shingle/" /> </div> </div> <div class="advance-search" style=""> <a id="ctl00_ctl51_Header_SearchTopBoxControl_lnkAdvanceSearch" href="https://journals.lww.com/ajsp/pages/advancedsearch.aspx">Advanced Search</a> <input type="submit" name="ctl00$ctl51$Header$SearchTopBoxControl$btnGlobalSearch" value="" id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch" disabled="disabled" class="aspNetDisabled btnGlobalSearch" style="display: none;" /> <input name="ctl00$ctl51$Header$SearchTopBoxControl$hfldKeywords" type="hidden" id="ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords" class="hfldKeywords" value="disableButton" /> </div> </div> <script> $(function() { try { var objSearchBox = { btnGlobalSearchMagnifierId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier', searchButtonId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch', txtKeywordsId: 'ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords', hfldKeywordsHiddenId: 'ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords', defaultSearchText: 'Search' }; new Searchbox(objSearchBox).Init(); } catch (e) { console.error(e); } }); //autocomplete functionality for basic search //this functionality will call the SBA url and start suggesting after typing 3rd character var textKeywords = null; var hiddenAutocompleteApiUrl = null; var buttonGlobalSearch = null; $(function () { try { var objAutocomplete = { hiddenIsAutoCompleteEnabled: $('#ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled'), textKeywords: $('#ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords'), hiddenAutocompleteApiUrl: $('#ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl'), buttonGlobalSearch: $('#ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch'), enableNewAutoComplete: true, newAutoCompleteUrl: 'https://dxg-search-na-prd.wkgposvc.cloud/Query.svc/Query_Expand', newAutoCompleteMaxSuggestions: '10', newAutoCompleteDictionaryIds: 'ovid_sted28_mesh22' }; autoComplete(objAutocomplete); } catch (e) { console.error(e); } }); $(function () { let searchSelect = $('select[id$="ddlContentScope"]');; if (searchSelect.length){ 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href="https://journals.lww.com/ajsp/pages/register.aspx?ContextUrl=%2fajsp%2fabstract%2f2020%2f03000%2fendometrial_gastric__gastrointestinal__type.12.aspx">Register</a> <button class="user-menu__link user-menu__link--login js-ejp-login-btn btn btn-default navbar-button" type="button" data-config="{&quot;eventName&quot;:&quot;login&quot;,&quot;eventDetail&quot;:{},&quot;isNull&quot;:false}"> <span>Login</span> </button> </div> <div id="ctl00_ctl51_TopNavigationMenuConfiguration" style="display:none" class="js-top-navigation-menu-configuration" data-config="{&quot;browsingHistory&quot;:{&quot;isEnabled&quot;:true,&quot;serviceUrl&quot;:&quot;https://apim-hlrp-ejp-prod.azure-api.net/ee&quot;,&quot;pdfDownloadUrl&quot;:&quot;/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=HistoryTab&quot;}}"></div> <div id="zz1_TopNavigationMenu" class="navbar-collapse collapse js-top-navigation-menu noindex ms-core-listMenu-horizontalBox"> <ul id="zz2_RootAspMenu" class="root 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Gastric (Gastrointestinal)-type Mucinous Lesions: Report of a Series Illustrating the Spectrum of Benign and Malignant Lesions', '09262019', 'Richard Wing-Cheuk Wong, Angela Ralte, Katherine Grondin, et al', '44', '3', 'Copyright \u00A9 2019 Wolters Kluwer Health, Inc. All rights reserved.', '00000478-202003000-00012', '', false, ''); } </script> <div id="ArticleContainer"> <article id="ej-abstract-view" xmlns:ssr="http://ssr-eus-go-csi.cloudapp.net/v1/assets" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xhtml="http://www.w3.org/1999/xhtml"><section class="ejp-r-article-subsection"><div class="ejp-r-article-subsection__text">Original Articles</div></section><header class="ejp-article-header"><h1 class="ejp-article-title">Endometrial Gastric (Gastrointestinal)-type Mucinous Lesions</h1> <h2 class="article-subtitle">Report of a Series Illustrating the Spectrum of Benign and Malignant Lesions</h2></header><section id="ejp-article-authors"><p id="P7">Wong, Richard Wing-Cheuk FRCPA<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>; Ralte, Angela FRCPath<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">†</sup>; Grondin, Katherine MD, PhD<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">‡</sup>; Talia, Karen L. FRCPA<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">§</sup>; McCluggage, W. Glenn FRCPath<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">∥</sup></p><section><a href="#" id="ejp-article-authors-link"> Author Information <i class="wk-icon-arrow-down-r"></i></a></section></section><section id="ejp-article-authors-info" class="ejp-article-authors-info ejp-article-authors-info--hidden"><div class="ejp-article-authors-info-holder"> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">*</sup>Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">†</sup>Department of Pathology, Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust, Gateshead</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">∥</sup>Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">‡</sup>Department of Pathology, CHU de Québec-Université Laval, Quebec City, QC, Canada</p> <p id=""><sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">§</sup>VCS Pathology, VCS Foundation, Carlton, Vic., Australia</p> <p id="">Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.</p> <p id="">Correspondence: Richard Wing-Cheuk Wong, FRCPA, Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong (e-mail: <span><a href="/cdn-cgi/l/email-protection#e08d81898c948fda979783d0d9d1a08881ce8f9287ce888b" onclick="javascript:window.open('mailto:mailto:wwc091@ha.org.hk');return false"><span class="__cf_email__" data-cfemail="8ef9f9edbeb7bfcee6efa0e1fce9a0e6e5">[email&#160;protected]</span></a></span>).</p> </div></section><section id="article-journal-info"><div class="ej-journal-info"><span class="ej-journal-name">The American Journal of Surgical Pathology </span><span id="ej-journal-date-volume-issue-pg"><a href="/ajsp/toc/2020/03000">44(3):p 406-419, March 2020.</a></span><span> | </span><span class="ej-journal-doi">DOI: </span>10.1097/PAS.0000000000001381</div></section><section id="ejp-article-indicators" class="ejp-article-indicators"><ul class="ejp-article-indicators__list"> <li id="ej-article-indicators-buy" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()"><a href="#ContentAccessOptions"><span class="ejp-indicator">Buy</span></a></li> <li id="ej-article-indicators-sam" class="ejp-article-indicators__list-item" onmouseover="javascript:Tooltip_SDC()" onmouseout="javascript:Tooltip_MouseOut()"><span class="ejp-indicator">SDC</span></li> </ul><button id="openArticleMetricsPopupButton" type="button" class="wk-button wk-button-ghost wk-button-icon-left ejp-article-metrics-btn" data-articleMetricsEndpoint="//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc" data-articleMetricsDetailsUrl="https://wolterskluwer.altmetric.com/details/" data-doi="10.1097/PAS.0000000000001381" data-suiteId="vrs_woltere_journalsglobalvrs" data-articlePublicationDate="2019-09-26" data-articlePublicationDateString="September 26, 2019" data-receivedDate="" data-revisionReceivedDate="" data-acceptedDate="" data-crossrefRefLinkRoot="https://doi.org/" data-medlineRefLinkRoot="http://www.ncbi.nlm.nih.gov/pubmed/" data-pubMedId="31567280"><i class="wk-icon-filled-chart-r"></i><i class="wk-icon-filled-chart-white-r"></i> Metrics </button></section><section class="ejp-article-tabs" id="abstractWrap"><h2 class="ejp-article-tabs-heading">Abstract</h2> <div class="ejp-article-tabs__tabpanel" id="panel1" role="tabpanel" aria-labelledby="tab1"> <div id="article-abstract-content1"> <div class="ejp-article-text-abstract"> <p>With the recent elucidation of gastric-type lesions in the female genital tract (especially in the cervix), occasional cases of endometrial adenocarcinoma displaying gastric (gastrointestinal) differentiation have been reported, but they are currently not recognized as a distinct pathologic entity. We report 9 cases of endometrial mucinous lesions which exhibit gastric (gastrointestinal)-type features by morphology and immunohistochemistry, including 4 adenocarcinomas and 5 benign mucinous lesions, in patients aged 32 to 85. The adenocarcinomas showed gastric-type morphology in all 4 cases and goblet cells in 1, with a component of benign gastric-type mucinous glands in 1 case. Immunohistochemically, the adenocarcinomas were positive for CK7 (4/4), CEA (4/4), MUC6 (3/3), PAX8 (3/4), CK20 (2/4), CDX2 (2/4), and estrogen receptor (1/4). They were negative for Napsin A (0/3), with mutation-type p53 staining in 2/4 cases, block-type p16 positivity in 1/4, and scattered chromogranin-positive cells in 1/2. Targeted next-generation sequencing revealed nonsense mutation in <em xmlns:mrws="http://webservices.ovid.com/mrws/1.0">RB1</em> gene for the case with block-positive p16. Follow-up was available in all adenocarcinoma cases and indicated aggressive behavior; 2 patients were dead of disease at follow-up of 7 months to 3 years, 1 was alive with progression at 9 months, and 1 was alive without disease at 7 months. The benign mucinous lesions (including the benign component in 1 adenocarcinoma) exhibited gastric-type morphologic features in 5/6 cases, goblet cells in 5/6, and Paneth-like neuroendocrine cells in 1/6. These benign mucinous lesions were associated with an endometrial polyp in 5/6 cases. Cytologic atypia was present in 2/6 cases and a lobular architecture resembling cervical lobular endocervical glandular hyperplasia in 4/6. Immunohistochemically, the benign mucinous lesions were positive for CK7 (5/5), CDX2 (5/6), estrogen receptor (4/5), MUC6 (4/5), CK20 (3/5), PAX8 (3/5), and CEA (2/4), with scattered chromogranin-positive cells in 4/4 cases; in all cases tested Napsin A was negative, p53 was wild-type and p16 was negative. We propose the term “endometrial gastric (gastrointestinal)-type adenocarcinoma” for this distinctive group of rare aggressive endometrial carcinomas. We believe that benign or atypical gastric (gastrointestinal)-type mucinous lesions are putative precursors for these adenocarcinomas, comparable to recognized premalignant gastric-type lesions in the cervix and the vagina. Future recognition and reporting of these gastric-type endometrial mucinous lesions will help delineate their pathogenesis and clinical significance.</p> </div> </div> </div></section><section class="ej-article-copyright">Copyright © 2019 Wolters Kluwer Health, Inc. 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To keep this Web Part, click Cancel.';var lblColleaguesEmail = $get('ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_lblColleaguesEmail'); var Page_ValidationActive = false; if (typeof(ValidatorOnLoad) == "function") { ValidatorOnLoad(); } function ValidatorOnSubmit() { if (Page_ValidationActive) { return ValidatorCommonOnSubmit(); } else { return true; } } //]]> </script> <script type='text/javascript'>SP.SOD.set_prefetch(0);</script> <script type="text/javascript"> //<![CDATA[ WPSC.Init(document); var varPartWPQ1 = WPSC.WebPartPage.Parts.Register('WPQ1','ce0f8ecf-65f7-4a26-939e-2bbb37977f2c',document.getElementById('WebPartWPQ1')); var varPartWPQ2 = WPSC.WebPartPage.Parts.Register('WPQ2','48ec8185-1b32-4da1-96aa-6c91a856c108',document.getElementById('WebPartWPQ2')); var varPartWPQ3 = WPSC.WebPartPage.Parts.Register('WPQ3','2a05994c-ddb4-4373-b9a1-049ed15429cc',document.getElementById('WebPartWPQ3')); var varPartWPQ4 = WPSC.WebPartPage.Parts.Register('WPQ4','55b6e16c-7ed5-4ab6-a182-34f5ecf40587',document.getElementById('WebPartWPQ4')); var varPartWPQ5 = WPSC.WebPartPage.Parts.Register('WPQ5','c790b33c-5b93-4b04-adb5-f1eb6d570c4c',document.getElementById('WebPartWPQ5')); var varPartWPQ6 = WPSC.WebPartPage.Parts.Register('WPQ6','8dcc7734-ef3b-4dad-8855-ec5f7e54440d',document.getElementById('WebPartWPQ6')); WPSC.WebPartPage.WebURL = 'https:\u002f\u002fjournals.lww.com\u002fajsp'; WPSC.WebPartPage.WebServerRelativeURL = '\u002fajsp'; var g_clientIdDeltaPlaceHolderMain = "DeltaPlaceHolderMain"; var g_clientIdDeltaPlaceHolderUtilityContent = "DeltaPlaceHolderUtilityContent"; WebForm_AutoFocus('ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_emailToColleague_txtYourName');Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pnlunSubscribeToAlerts","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"unSubscribeToAlerts"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_dummyTargetControl")); }); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"subscribeToEtoc"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl")); }); document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').dispose = function() { Array.remove(Page_Validators, document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError')); } g_QuickLaunchControlIds.push("zz1_TopNavigationMenu");_spBodyOnLoadFunctionNames.push('QuickLaunchInitDroppable'); var g_zz1_TopNavigationMenu = null; function init_zz1_TopNavigationMenu() { if (g_zz1_TopNavigationMenu == null) g_zz1_TopNavigationMenu = $create(SP.UI.AspMenu, null, null, null, $get('zz1_TopNavigationMenu')); } if(g_spPreFetchKeys) {{ g_spPreFetchKeys.push('SP.Core.js');}}EnsureScriptFunc('SP.Core.js', 'SP.UI.AspMenu', init_zz1_TopNavigationMenu); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_pnlEmailToColleague","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"emailToColleaguePopupExtender_1605895285"}, null, null, $get("ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_emailToColleagueControl_hypEmailToColleague")); }); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_exportToCitationManager_pnlExportTo","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"OpenExportToPopupExtender_566456402"}, null, null, $get("ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_ucArticleTools_exportToCitationManager_hypExportToCitationManager")); }); Sys.Application.add_init(function() { $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_emailToColleague_pnlEmailToColleague","dynamicServicePath":"/ajsp/pages/articleviewer.aspx","id":"emailToColleaguePopupExtender_1479463072"}, null, null, $get("ctl00_ctl29_g_60b9c391_4bd7_4f45_ae6b_9b5338b7d65c_ctl00_emailToColleague_hypEmailToColleague")); }); //]]> </script> </form> <span id="DeltaPlaceHolderUtilityContent"> </span> <script type="text/javascript">// <![CDATA[ var g_Workspace = "s4-workspace"; // ]]> </script> <div id="ctl00_ctl64_divAdConfig" data-adconfig="{&quot;adTitle&quot;:&quot;Advertisement&quot;,&quot;slotClass&quot;:&quot;ad-slot-container&quot;,&quot;topBanner&quot;:{&quot;sticky&quot;:&quot;true&quot;,&quot;stickyDuration&quot;:&quot;5000&quot;},&quot;lazyLoadingEnabled&quot;:false,&quot;npiHash&quot;:&quot;&quot;,&quot;pageTargeting&quot;:{&quot;ArticleId&quot;:&quot;00000478-202003000-00012&quot;}}" data-videoadconfig="{&quot;serverURL&quot;:&quot;https://pubads.g.doubleclick.net/gampad/ads&quot;,&quot;sizes&quot;:&quot;320x180|640x360&quot;,&quot;overlayUnitPath&quot;:&quot;/15726702761/Desktop/ajsp/Video/overlay&quot;,&quot;prerollUnitPath&quot;:&quot;/15726702761/Desktop/ajsp/Video/pre-roll&quot;,&quot;postrollUnitPath&quot;:&quot;/15726702761/Desktop/ajsp/Video/post-roll&quot;}" class="js-ad-config"> </div> <div id="ctl00_ctl64_divScripts"><script type="text/plain" async="async" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js" class="optanon-category-C0004"></script> <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/ads.js?v=05.24.00.023" defer="true"> </script> </div> <!-- Control to add scripts depending on settings from Configuration DB like --> <script type="text/javascript"> (function($) { if (false) { $(".top-microbar-container").addClass('top-microbar-container-moved').insertAfter(".advertisement-content_top"); } $(function () { if (false) { $( '<div class="top-banner-verify-email">Be sure to check your email to verify your new user account! Thanks!</div>') .insertAfter(".top-microbar-container"); } }); })(jQuery); </script> <script type="text/javascript"> window.twttr = (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0], t = window.twttr || {}; if (d.getElementById(id)) return t; js = d.createElement(s); js.id = id; js.src = "https://platform.twitter.com/widgets.js"; fjs.parentNode.insertBefore(js, fjs); t._e = []; t.ready = function(f) { t._e.push(f); }; return t; }(document, "script", "twitter-wjs")); </script> <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/ee.js?v=05.24.00.023" defer="true"> </script> <script type="text/javascript"> function OTScriptExecutedEventHandler(e) { if (window.WKTracker && window.TrackingSetup) { window.TrackingSetup.api = window.TrackingSetup.api || {}; window.TrackingSetup.api.baseUrl = 'https://apim-hlrp-ejp-prod.azure-api.net/ee'; window.TrackingSetup.api.log = window.TrackingSetup.api.log || {}; window.TrackingSetup.api.resolve = window.TrackingSetup.api.resolve || {}; window.TrackingSetup.gdpr = window.TrackingSetup.gdpr || {}; window.TrackingSetup.gdpr.cookieUsageConsent = window.cookieUsageConsent || false; window.WKTracker.configure(window.TrackingSetup); window.WKTracker.track(); // Remove the event listener window.removeEventListener('OTScriptExecuted', OTScriptExecutedEventHandler); } } window.addEventListener('OTScriptExecuted', OTScriptExecutedEventHandler); </script> <script>(function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'8eb2a66efca7ce46',t:'MTczMzA1MTYzOC4wMDAwMDA='};var a=document.createElement('script');a.nonce='';a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();</script></body> </html>

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