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Page</span> <span class="mobile_menu_bar mobile_menu_bar_toggle"></span> </div> </div> </div>  </div>  </header>  <div id="et-main-area"> <div id="main-content"> <article id="post-224" class="post-224 page type-page status-publish hentry"> <div class="entry-content"> <div class="et-l et-l--post"> <div class="et_builder_inner_content et_pb_gutters3"> <div class="et_pb_section et_pb_section_0 et_animated et_pb_with_background et_pb_fullwidth_section et_section_regular" > <section class="et_pb_module et_pb_fullwidth_header et_pb_fullwidth_header_0 et_animated et_pb_text_align_left et_pb_bg_layout_dark"> <div class="et_pb_fullwidth_header_container left"> <div class="header-content-container center"> <div class="header-content"> <h1 class="et_pb_module_header">Technology</h1> <div class="et_pb_header_content_wrapper"></div> </div> </div> </div> <div class="et_pb_fullwidth_header_overlay"></div> <div class="et_pb_fullwidth_header_scroll"></div> </section> </div><div class="et_pb_section et_pb_section_1 et_section_regular" > <div class="et_pb_row et_pb_row_0 et_pb_equal_columns"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 subtitle et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>TECHNOLOGY</p></div> </div><div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2>Barinthus Biotherapeutics has a powerful suite of innovative technologies to create effective immunotherapies.</h2></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_0 rule et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div> </div> </div><div class="et_pb_row et_pb_row_1"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>The depth and breadth of our capabilities is what sets us apart. Our proprietary vectored and synthetic platform technologies are based on decades of research at leading institutions (NIH, University of Oxford) and have been optimized to meet the demands of different therapeutic applications.</p> <p>For each therapeutic area we draw upon a broad toolbox of platform technologies for systematically engineering product candidates that aim to overcome disease and address patient needs. This is achieved through the modularity of our platforms which can be uniquely tailored to guide T cell responses, with a focus on two main approaches:</p> <ul> <li>Reducing inflammation to treat autoimmunity and other inflammatory diseases.</li> <li>Eliminating virally infected or cancerous cells to treat chronic infectious diseases and cancer.</li> </ul></div> </div> </div> </div> </div><div class="et_pb_section et_pb_section_2 et_section_regular" > <div class="et_pb_row et_pb_row_2 et_pb_equal_columns"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_2 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_3 subtitle et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner">OUR PLATFORMS</div> </div><div class="et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h3>SNAP </h3></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_1 rule et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div> </div> </div><div class="et_pb_row et_pb_row_3"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_3 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>Our proprietary SNAP (Self-assembling Nanoparticles based on Amphiphilic Peptides) platform was developed to address the need for co-delivering multiple active pharmaceutical ingredients in nanoparticles. This fully synthetic, biocompatible platform utilizes self-assembly to co-deliver multiple antigens and immunomodulators. This approach allows for nanoparticles of a precise, programmable size and composition for inducing the specific T cell populations needed for diverse therapeutic indications.</p> <p>The SNAP platform optimized for promoting tolerance for treating autoimmunity and other inflammatory diseases is referred to as SNAP Tolerance Immunotherapy, abbreviated as “SNAP-TI.”</p></div> </div><div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_module "> <a id="bullet-button" class="et_pb_button et_pb_button_0 bullet-button et_pb_bg_layout_light" href="https://www.barinthusbio.com/technology/snap-ti/" data-icon="5">SNAP-TI</a> </div> </div> </div> </div><div class="et_pb_section et_pb_section_3 et_section_regular" > <div class="et_pb_row et_pb_row_4 et_pb_equal_columns"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_4 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_6 subtitle et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner">OUR PLATFORMS</div> </div><div class="et_pb_module et_pb_text et_pb_text_7 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h3>Vectored Platforms</h3></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_2 rule et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div> </div> </div><div class="et_pb_row et_pb_row_5"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_5 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_8 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>Barinthus Bio has deep capabilities and expertise in the design and optimization of vectored and nucleic acid-based platforms. Our most advanced vectored platforms are ChAdOx1 (Chimpanzee Adenovirus Oxford), which is a modified, replication-incompetent simian adenoviral vector, and Modified Vaccinia Ankara (MVA), a well-studied attenuated vaccinia virus.</p> <p>Our vectored platforms are optimized for promoting highly disease (antigen)-specific T cells against target antigens encoded by the vectors. For treatment of chronic infectious diseases and cancer, we have optimized an approach whereby ChAdOx and MVA are given sequentially to maximize T cell immunity. This differentiated approach reproducibly achieves high magnitude, quality, and durability of antigen-specific CD4 helper and CD8 cytotoxic T cells ideal for treating infectious diseases and cancer.</p></div> </div><div class="et_pb_button_module_wrapper et_pb_button_1_wrapper et_pb_module "> <a id="bullet-button" class="et_pb_button et_pb_button_1 bullet-button et_pb_bg_layout_light" href="/technology/viral-vector-platforms/" data-icon="5">Viral Vector Platforms</a> </div> </div> </div> </div> </div> </div> </div> </article> </div> <footer class="et-l et-l--footer"> <div class="et_builder_inner_content et_pb_gutters3"> <div class="et_pb_section et_pb_section_0_tb_footer et_section_regular" > <div class="et_pb_row et_pb_row_0_tb_footer"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_0_tb_footer et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_with_border et_pb_module et_pb_divider_0_tb_footer et_pb_space et_pb_divider_hidden"><div 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https://www.barinthusbio.com/storage/2023/10/Barinthus_Biotherapeutics_Logo_White1-480x160.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 800px, 100vw" class="wp-image-30339" /></span> </div><div class="et_pb_module et_pb_text et_pb_text_2_tb_footer et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>Barinthus Biotherapeutics is a clinical-stage biopharmaceutical company focused on the development of antigen-specific immunotherapeutics that induce T cells to treat chronic viral infections, autoimmune diseases, and cancer.</p></div> </div> </div> </div> </div><div class="et_pb_with_border et_pb_section et_pb_section_2_tb_footer et_pb_with_background et_section_regular" > <div class="et_pb_row et_pb_row_2_tb_footer et_pb_equal_columns"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_4_tb_footer et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_3_tb_footer et_pb_text_align_left 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