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Meibomian gland - Wikipedia
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class="vector-toc-link" href="#Lipids"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1.1</span> <span>Lipids</span> </div> </a> <ul id="toc-Lipids-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Proteins" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Proteins"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1.2</span> <span>Proteins</span> </div> </a> <ul id="toc-Proteins-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Clinical significance</span> </div> </a> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a 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class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Meibomian gland</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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mw-list-item"><a href="https://ca.wikipedia.org/wiki/Gl%C3%A0ndula_de_Meibom" title="Glàndula de Meibom – Catalan" lang="ca" hreflang="ca" data-title="Glàndula de Meibom" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Meibom-Dr%C3%BCse" title="Meibom-Drüse – German" lang="de" hreflang="de" data-title="Meibom-Drüse" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Gl%C3%A1ndula_de_Meibomio" title="Glándula de Meibomio – Spanish" lang="es" hreflang="es" data-title="Glándula de Meibomio" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Glande_de_Meibomius" title="Glande de Meibomius – French" lang="fr" hreflang="fr" data-title="Glande de Meibomius" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Gl%C3%A1ndula_de_Meibomio" title="Glándula de Meibomio – Galician" lang="gl" hreflang="gl" data-title="Glándula de Meibomio" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%A7%88%EC%9D%B4%EB%B4%84%EC%83%98" title="마이봄샘 – Korean" lang="ko" hreflang="ko" data-title="마이봄샘" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Ghiandola_di_Meibomio" title="Ghiandola di Meibomio – Italian" lang="it" hreflang="it" data-title="Ghiandola di Meibomio" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Meibomo_liaukos" title="Meibomo liaukos – Lithuanian" lang="lt" hreflang="lt" data-title="Meibomo liaukos" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Klieren_van_Meibom" title="Klieren van Meibom – Dutch" lang="nl" hreflang="nl" data-title="Klieren van Meibom" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%9E%E3%82%A4%E3%83%9C%E3%83%BC%E3%83%A0%E8%85%BA" title="マイボーム腺 – Japanese" lang="ja" hreflang="ja" data-title="マイボーム腺" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Meibomske_kjertler" title="Meibomske kjertler – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Meibomske kjertler" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Meybomiy_bezlari" title="Meybomiy bezlari – Uzbek" lang="uz" hreflang="uz" data-title="Meybomiy bezlari" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Gruczo%C5%82_tarczkowy" title="Gruczoł tarczkowy – Polish" lang="pl" hreflang="pl" data-title="Gruczoł tarczkowy" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Gl%C3%A2ndula_acinotarsal" title="Glândula acinotarsal – Portuguese" lang="pt" hreflang="pt" data-title="Glândula acinotarsal" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9C%D0%B5%D0%B9%D0%B1%D0%BE%D0%BC%D0%B8%D0%B5%D0%B2%D1%8B_%D0%B6%D0%B5%D0%BB%D0%B5%D0%B7%D1%8B" title="Мейбомиевы железы – Russian" lang="ru" hreflang="ru" data-title="Мейбомиевы железы" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%9C%D0%B5%D0%B8%D0%B1%D0%BE%D0%BC%D1%81%D0%BA%D0%B5_%D0%B6%D0%BB%D0%B5%D0%B7%D0%B4%D0%B5" title="Меибомске жлезде – Serbian" lang="sr" hreflang="sr" data-title="Меибомске жлезде" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Meibomin_rauhanen" title="Meibomin rauhanen – Finnish" lang="fi" hreflang="fi" data-title="Meibomin rauhanen" 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id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Sebaceous glands along the rims of the eyelid</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color:dimgray; color: white">Meibomian gland</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Gray1205.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Gray1205.png/250px-Gray1205.png" decoding="async" width="250" height="204" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Gray1205.png/375px-Gray1205.png 1.5x, //upload.wikimedia.org/wikipedia/commons/1/1e/Gray1205.png 2x" data-file-width="429" data-file-height="350" /></a></span><div class="infobox-caption">Front of left eye with eyelids separated to show medial canthus and openings of meibomian (tarsal) glands</div></td></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Human_eye_with_eyelid_pulled_open,_anterior_view.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg/250px-Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg" decoding="async" width="250" height="188" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg/375px-Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/10/Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg/500px-Human_eye_with_eyelid_pulled_open%2C_anterior_view.jpg 2x" data-file-width="2136" data-file-height="1602" /></a></span><div class="infobox-caption">Openings of the meibomian glands visible below the <a href="/wiki/Eyelash" title="Eyelash">eyelashes</a> of the upper eyelid</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Details</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Organ_system" title="Organ system">System</a></th><td class="infobox-data">Integumentary</td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Latin" title="Latin">Latin</a></th><td class="infobox-data"><i>glandula tarsalis</i></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D008537">D008537</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Terminologia_Anatomica" title="Terminologia Anatomica">TA98</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://ifaa.unifr.ch/Public/EntryPage/TA98%20Tree/Entity%20TA98%20EN/15.2.07.042%20Entity%20TA98%20EN.htm">A15.2.07.042</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Terminologia_Anatomica" title="Terminologia Anatomica">TA2</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://ta2viewer.openanatomy.org/?id=6833">6833</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Foundational_Model_of_Anatomy" title="Foundational Model of Anatomy">FMA</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://bioportal.bioontology.org/ontologies/FMA/?p=classes&conceptid=http%3A%2F%2Fpurl.org%2Fsig%2Font%2Ffma%2Ffma71872">71872</a></td></tr><tr><td colspan="2" class="infobox-below"><a href="/wiki/Anatomical_terminology" title="Anatomical terminology">Anatomical terminology</a><div style="text-align: right;"><small class="noprint">[<a href="https://www.wikidata.org/wiki/Q1425513" class="extiw" title="d:Q1425513">edit on Wikidata</a>]</small></div></td></tr></tbody></table> <p><b>Meibomian glands</b> (also called <b>tarsal glands</b>, <b>palpebral glands</b>, and <b>tarsoconjunctival glands</b>) are <a href="/wiki/Sebaceous_gland" title="Sebaceous gland">sebaceous glands</a> along the rims of the <a href="/wiki/Eyelid" title="Eyelid">eyelid</a> inside the <a href="/wiki/Tarsal_plate" class="mw-redirect" title="Tarsal plate">tarsal plate</a>. They produce <b>meibum</b>, an oily substance that prevents evaporation of the <a href="/wiki/Eye" title="Eye">eye's</a> <a href="/wiki/Tear_film" class="mw-redirect" title="Tear film">tear film</a>. Meibum prevents <a href="/wiki/Tears" title="Tears">tears</a> from spilling onto the cheek, traps them between the oiled edge and the eyeball, and makes the closed lids airtight.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> There are about 25 such glands on the upper eyelid, and 20 on the lower eyelid. </p><p><a href="/wiki/Meibomian_gland_dysfunction" title="Meibomian gland dysfunction">Dysfunctional meibomian glands</a> is believed to be the most often cause of <a href="/wiki/Dry_eye" class="mw-redirect" title="Dry eye">dry eyes</a>. They are also the cause of <a href="/wiki/Blepharitis" title="Blepharitis">posterior blepharitis</a>.<sup id="cite_ref-workshop-summary_2-0" class="reference"><a href="#cite_note-workshop-summary-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Meibomian_gland_by_heinrich_meibom.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Meibomian_gland_by_heinrich_meibom.png/220px-Meibomian_gland_by_heinrich_meibom.png" decoding="async" width="220" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Meibomian_gland_by_heinrich_meibom.png/330px-Meibomian_gland_by_heinrich_meibom.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Meibomian_gland_by_heinrich_meibom.png/440px-Meibomian_gland_by_heinrich_meibom.png 2x" data-file-width="881" data-file-height="480" /></a><figcaption>First drawing of the meibomian gland by <a href="/wiki/Heinrich_Meibom_(doctor)" title="Heinrich Meibom (doctor)">Heinrich Meibom</a>. Year 1666.</figcaption></figure> <p>The glands were mentioned by <a href="/wiki/Galen" title="Galen">Galen</a> in 200 AD<sup id="cite_ref-workshop-04_3-0" class="reference"><a href="#cite_note-workshop-04-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> and were described in more detail by <a href="/wiki/Heinrich_Meibom_(doctor)" title="Heinrich Meibom (doctor)">Heinrich Meibom</a> (1638–1700), a German physician, in his work <i>De Vasis Palpebrarum Novis Epistola</i> in 1666. This work included a drawing with the basic characteristics of the glands.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Anatomy">Anatomy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=2" title="Edit section: Anatomy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Although the upper lid have greater number and volume of meibomian glands than the lower lid, there is no consensus whether it contributes more to the tearfilm stability. The glands do not have direct contact with eyelash follicles. The process of blinking releases meibum into the lid margin.<sup id="cite_ref-workshop-summary_2-1" class="reference"><a href="#cite_note-workshop-summary-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Meibum">Meibum</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=4" title="Edit section: Meibum"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading4"><h4 id="Lipids">Lipids</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=5" title="Edit section: Lipids"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Lipid" title="Lipid">Lipids</a> are the major components of meibum (also known as "meibomian gland secretions"). The term "meibum" was originally introduced by Nicolaides <i>et al.</i> in 1981.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>The biochemical composition of meibum is extremely complex and very different from that of <a href="/wiki/Sebum" class="mw-redirect" title="Sebum">sebum</a>. Lipids are universally recognized as major components of human and animal meibum. An update<sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Please_clarify" title="Wikipedia:Please clarify"><span title="The text near this tag may need clarification or removal of jargon. (December 2020)">clarification needed</span></a></i>]</sup> was published in 2009 on the composition of human meibum and on the structures of various positively identified meibomian lipids.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Currently, the most sensitive and informative approach to lipidomic analysis of meibum is <a href="/wiki/Mass_spectrometry" title="Mass spectrometry">mass spectrometry</a>, either with direct infusion<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> or in combination with <a href="/wiki/Liquid_chromatography" class="mw-redirect" title="Liquid chromatography">liquid chromatography</a>.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The lipids are the main component of the lipid layer of the tear film, preventing rapid evaporation and it is believed they lower the surface tension which helps to stabilize the tear film.<sup id="cite_ref-workshop-04_3-1" class="reference"><a href="#cite_note-workshop-04-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Proteins">Proteins</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=6" title="Edit section: Proteins"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In humans, more than 90 different proteins have been identified in meibomian gland secretions.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=7" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Meibomian_gland_dysfunction" title="Meibomian gland dysfunction">Meibomian gland dysfunction</a></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Meibomian-glands.png" class="mw-file-description"><img alt="Meibomian glands in the lower eyelid imaged under amber light to show vasculature support and the gland structure [epiCam]." src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Meibomian-glands.png/220px-Meibomian-glands.png" decoding="async" width="220" height="235" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Meibomian-glands.png/330px-Meibomian-glands.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Meibomian-glands.png/440px-Meibomian-glands.png 2x" data-file-width="654" data-file-height="698" /></a><figcaption>Meibomian glands in the lower eyelid imaged under amber light to show vasculature support and the gland structure.</figcaption></figure> <p>Dysfunctional meibomian glands often cause <a href="/wiki/Dry_eye" class="mw-redirect" title="Dry eye">dry eyes</a>, one of the more common eye conditions. They may also contribute to <a href="/wiki/Blepharitis" title="Blepharitis">blepharitis</a>. Inflammation of the meibomian glands (also known as <i>meibomitis</i>, <i>meibomian gland dysfunction</i>, or <i>posterior blepharitis</i>) causes the glands to be obstructed by thick, cloudy-to-yellow, more opaque and viscous-like, oily and waxy secretions, a change from the glands' normal clear secretions.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-auto_13-0" class="reference"><a href="#cite_note-auto-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Besides leading to dry eyes, the obstructions can be degraded by bacterial <a href="/wiki/Lipase" title="Lipase">lipases</a>, resulting in the formation of free <a href="/wiki/Fatty_acid" title="Fatty acid">fatty acids</a>, which irritate the eyes and sometimes cause <a href="/wiki/Thygeson%27s_superficial_punctate_keratopathy" title="Thygeson's superficial punctate keratopathy">punctate keratopathy</a>. </p><p>Meibomian gland dysfunction is more often seen in women and is regarded as the main cause of <a href="/wiki/Dry_eye_disease" class="mw-redirect" title="Dry eye disease">dry eye disease</a>.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Factors that contribute to meibomian gland dysfunction can include things such as a person's age and/or hormones,<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> or severe infestation of <a href="/wiki/Demodex_brevis" title="Demodex brevis">Demodex brevis</a> mite. </p><p>Treatment can include <a href="/wiki/Warm_compresses" class="mw-redirect" title="Warm compresses">warm compresses</a> to thin the secretions and eyelid scrubs with a commercial eyelid cleanser or baby shampoo,<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-auto_13-1" class="reference"><a href="#cite_note-auto-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> or emptying ("expression") of the gland by a professional. <a href="/wiki/Lifitegrast" title="Lifitegrast">Lifitegrast</a> and <a href="/wiki/Ciclosporin" title="Ciclosporin">ciclosporin</a> are topical medication commonly used to control the inflammation and improve the oil quality. In some cases, topical <a href="/wiki/Steroid" title="Steroid">steroids</a> and topical (drops or ointment)/oral <a href="/wiki/Antibiotic" title="Antibiotic">antibiotics</a> (to reduce bacteria on the lid margin) are also prescribed to reduce inflammation.<sup id="cite_ref-auto_13-2" class="reference"><a href="#cite_note-auto-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Intense_pulsed_light" title="Intense pulsed light">Intense pulsed light</a> (IPL) treatments have also been shown to reduce inflammation and improve gland function. Meibomian gland probing is also used on patients who experience deep clogging of the glands. </p><p>Meibomian gland dysfunction may be caused by some <a href="/wiki/Pharmaceutical_drug" class="mw-redirect" title="Pharmaceutical drug">prescription medications</a>, notably <a href="/wiki/Isotretinoin" title="Isotretinoin">isotretinoin</a>. A blocked meibomian gland can cause a <a href="/wiki/Chalazion" title="Chalazion">chalazion</a> (or "meibomian cyst") to form in the eyelid. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=8" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Gland_of_Zeis" title="Gland of Zeis">Gland of Zeis</a></li> <li><a href="/wiki/List_of_specialized_glands_within_the_human_integumentary_system" class="mw-redirect" title="List of specialized glands within the human integumentary system">List of specialized glands within the human integumentary system</a></li> <li><a href="/wiki/Meibomian_gland_dysfunction" title="Meibomian gland dysfunction">Meibomian gland dysfunction</a></li> <li><a href="/wiki/Moll%27s_gland" title="Moll's gland">Moll's gland</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text">"eye, human." Encyclopædia Britannica. <a href="/wiki/Encyclop%C3%A6dia_Britannica_Ultimate_Reference_Suite" title="Encyclopædia Britannica Ultimate Reference Suite">Encyclopædia Britannica Ultimate Reference Suite</a>. 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Medicine&rft.atitle=Efficacy+of+baby+shampoo+and+commercial+eyelid+cleanser+in+patients+with+meibomian+gland+dysfunction&rft.volume=99&rft.issue=19&rft.pages=e20155&rft.date=2020-05-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7220370%23id-name%3DPMC&rft_id=info%3Apmid%2F32384504&rft_id=info%3Adoi%2F10.1097%2FMD.0000000000020155&rft.aulast=Aryasit&rft.aufirst=Orapan&rft.au=Uthairat%2C+Yuwarat&rft.au=Singha%2C+Penny&rft.au=Horatanaruang%2C+Orasa&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7220370&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMeibomian+gland" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Meibomian_gland&action=edit&section=10" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><i><a rel="nofollow" class="external text" href="http://www.whonamedit.com/synd.cfm/541.html">synd/541</a></i> at <a href="/wiki/Whonamedit%3F" title="Whonamedit?">Whonamedit?</a></li> <li><a rel="nofollow" class="external text" href="http://www.aao.org/publications/eyenet/201107/cornea.cfm">Rethinking Meibomian Gland Dysfunction: How to Spot It, Stage It and Treat It</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output 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.mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="The_orbit_of_the_eye127" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Orbital_anatomy" title="Template:Orbital anatomy"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Orbital_anatomy" title="Template talk:Orbital anatomy"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Orbital_anatomy" title="Special:EditPage/Template:Orbital anatomy"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="The_orbit_of_the_eye127" style="font-size:114%;margin:0 4em">The <a href="/wiki/Orbit_(anatomy)" title="Orbit (anatomy)">orbit</a> of the <a href="/wiki/Human_eye" title="Human eye">eye</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Bones</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Frontal_bone" title="Frontal bone">Frontal bone</a></li> <li><a href="/wiki/Zygomatic_bone" title="Zygomatic bone">Zygomatic bone</a></li> <li><a href="/wiki/Maxilla" title="Maxilla">Maxillary bone</a></li> <li><a href="/wiki/Sphenoid_bone" title="Sphenoid bone">Sphenoid bone</a></li> <li><a href="/wiki/Ethmoid_bone" title="Ethmoid bone">Ethmoid bone</a></li> <li><a href="/wiki/Palatine_bone" title="Palatine bone">Palatine bone</a></li> <li><a href="/wiki/Lacrimal_bone" title="Lacrimal bone">Lacrimal bone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Extraocular_muscles" title="Extraocular muscles">Muscles</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Superior_rectus_muscle" title="Superior rectus muscle">Superior rectus muscle</a></li> <li><a href="/wiki/Inferior_rectus_muscle" title="Inferior rectus muscle">Inferior rectus muscle</a></li> <li><a href="/wiki/Lateral_rectus_muscle" title="Lateral rectus muscle">Lateral rectus muscle</a></li> <li><a href="/wiki/Medial_rectus_muscle" title="Medial rectus muscle">Medial rectus muscle</a></li> <li><a href="/wiki/Superior_oblique_muscle" title="Superior oblique muscle">Superior oblique muscle</a> <ul><li><a href="/wiki/Trochlea_of_superior_oblique" title="Trochlea of superior oblique">Trochlea of superior oblique</a></li></ul></li> <li><a href="/wiki/Inferior_oblique_muscle" title="Inferior oblique muscle">Inferior oblique muscle</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Eyelid" title="Eyelid">Eyelid</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Levator_palpebrae_superioris_muscle" title="Levator palpebrae superioris muscle">Levator palpebrae superioris muscle</a></li> <li><a href="/wiki/Tarsus_(eyelids)" title="Tarsus (eyelids)">Tarsus</a></li> <li><a href="/wiki/Medial_palpebral_ligament" title="Medial palpebral ligament">Medial palpebral ligament</a></li> <li><a href="/wiki/Epicanthic_fold" title="Epicanthic fold">Epicanthic fold</a></li> <li><a class="mw-selflink selflink">Meibomian gland</a></li> <li><a href="/wiki/Moll%27s_gland" title="Moll's gland">Ciliary glands</a></li> <li><a href="/wiki/Eyelash" title="Eyelash">Eyelash</a></li> <li><a href="/wiki/Palpebral_fissure" title="Palpebral fissure">Palpebral fissure</a></li> <li><a href="/wiki/Canthus" title="Canthus">Canthus</a></li> <li><a href="/wiki/Gland_of_Zeis" title="Gland of Zeis">Gland of Zeis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lacrimal_apparatus" title="Lacrimal apparatus">Lacrimal apparatus</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lacrimal_canaliculi" title="Lacrimal canaliculi">Lacrimal canaliculi</a></li> <li><a href="/wiki/Lacrimal_caruncle" title="Lacrimal caruncle">Lacrimal caruncle</a></li> <li><a href="/wiki/Lacrimal_gland" title="Lacrimal gland">Lacrimal gland</a></li> <li><a href="/wiki/Accessory_lacrimal_glands" title="Accessory lacrimal glands">Accessory lacrimal glands</a> <ul><li><a href="/wiki/Krause%27s_glands" title="Krause's glands">Krause's glands</a></li> <li><a href="/wiki/Ciaccio%27s_glands" title="Ciaccio's glands">Ciaccio's glands</a></li></ul></li> <li><a href="/wiki/Lacrimal_lake" title="Lacrimal lake">Lacrimal lake</a></li> <li><a href="/wiki/Lacrimal_papilla" title="Lacrimal papilla">Lacrimal papilla</a></li> <li><a href="/wiki/Lacrimal_punctum" title="Lacrimal punctum">Lacrimal punctum</a></li> <li><a href="/wiki/Lacrimal_sac" title="Lacrimal sac">Lacrimal sac</a></li> <li><a href="/wiki/Nasolacrimal_duct" title="Nasolacrimal duct">Nasolacrimal duct</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Eyebrow" title="Eyebrow">Eyebrow</a> <ul><li><a href="/wiki/Unibrow" title="Unibrow">Unibrow</a></li></ul></li> <li><a href="/wiki/Conjunctiva" title="Conjunctiva">Conjunctiva</a> <ul><li><a href="/wiki/Plica_semilunaris_of_conjunctiva" title="Plica semilunaris of conjunctiva">Plica semilunaris</a></li></ul></li> <li><a href="/wiki/Orbital_septum" title="Orbital septum">Orbital septum</a></li> <li><a href="/wiki/Periorbita" title="Periorbita">Periorbita</a></li> <li><a href="/wiki/Suspensory_ligament_of_eyeball" title="Suspensory ligament of eyeball">Suspensory ligament of eyeball</a></li> <li><a href="/wiki/Tenon%27s_capsule" title="Tenon's capsule">Tenon's capsule</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Epithelial_tissue48" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Epithelium_and_epithelial_tissue" title="Template:Epithelium and epithelial tissue"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Epithelium_and_epithelial_tissue" title="Template talk:Epithelium and epithelial tissue"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Epithelium_and_epithelial_tissue" title="Special:EditPage/Template:Epithelium and epithelial tissue"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Epithelial_tissue48" style="font-size:114%;margin:0 4em"><a href="/wiki/Epithelium" title="Epithelium">Epithelial</a> tissue</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Cells</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Squamous_epithelial_cell" class="mw-redirect" title="Squamous epithelial cell">Squamous </a></li> <li><a href="/wiki/Cuboidal_epithelial_cell" class="mw-redirect" title="Cuboidal epithelial cell">Cuboidal </a></li> <li><a href="/wiki/Columnar_epithelial_cell" class="mw-redirect" title="Columnar epithelial cell">Columnar</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Simple6" scope="row" class="navbox-group" style="width:1%">Simple</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Simple_squamous_epithelium" title="Simple squamous epithelium">Simple squamous epithelium</a> <ul><li><a href="/wiki/Endothelium" title="Endothelium">Endothelium</a></li> <li><a href="/wiki/Mesothelium" title="Mesothelium">Mesothelium</a></li></ul></li></ul> <ul><li><a href="/wiki/Simple_cuboidal_epithelium" title="Simple cuboidal epithelium">Simple cuboidal epithelium</a></li></ul> <ul><li><a href="/wiki/Simple_columnar_epithelium" title="Simple columnar epithelium">Simple columnar epithelium</a></li></ul> </div></td></tr></tbody></table><div> </div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">stratified</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Stratified_squamous_epithelium" title="Stratified squamous epithelium">Stratified squamous epithelium</a></li></ul> <ul><li><a href="/wiki/Stratified_cuboidal_epithelium" title="Stratified cuboidal epithelium">Stratified cuboidal epithelium</a></li></ul> <ul><li><a href="/wiki/Stratified_columnar_epithelium" title="Stratified columnar epithelium">Stratified columnar epithelium</a></li></ul> </div></td></tr></tbody></table><div> </div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pseudostratified_columnar_epithelium" title="Pseudostratified columnar epithelium">Pseudostratified columnar epithelium</a> <ul><li><a href="/wiki/Respiratory_epithelium" title="Respiratory epithelium">Respiratory epithelium</a></li></ul></li></ul> <ul><li><a href="/wiki/Transitional_epithelium" title="Transitional epithelium">Transitional epithelium</a> <ul><li><a href="/wiki/Urothelium" class="mw-redirect" title="Urothelium">Urothelium</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Glands</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Mechanism</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Merocrine" title="Merocrine">Merocrine</a> <ul><li><a href="/wiki/Eccrine_sweat_gland" title="Eccrine sweat gland">Eccrine</a></li></ul></li> <li><a href="/wiki/Apocrine" title="Apocrine">Apocrine</a></li> <li><a href="/wiki/Holocrine" title="Holocrine">Holocrine</a> <ul><li><a href="/wiki/Sebaceous_gland" title="Sebaceous gland">Sebaceous</a></li> <li><a class="mw-selflink selflink">Meibomian</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Shape</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tubular_gland" title="Tubular gland">Tubular gland</a></li> <li><a href="/wiki/Alveolar_gland" title="Alveolar gland">Alveolar gland</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Secretion</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Serous_gland" title="Serous gland">Serous glands</a></li> <li><a href="/wiki/Mucous_gland" title="Mucous gland">Mucous glands</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Components</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myoepithelial_cell" title="Myoepithelial cell">Myoepithelial cell</a></li> <li><a href="/wiki/Serous_demilune" title="Serous demilune">Serous demilune</a></li></ul> <ul><li><a href="/wiki/Duct_(anatomy)" title="Duct (anatomy)">Ducts</a> <ul><li><a href="/wiki/Intralobular_duct" class="mw-redirect" title="Intralobular duct">Intralobular</a></li> <li><a href="/wiki/Striated_duct" class="mw-redirect" title="Striated duct">Striated </a></li> <li><a href="/wiki/Intercalated_duct" class="mw-redirect" title="Intercalated duct">Intercalated </a></li></ul></li> <li><a href="/wiki/Acinus" title="Acinus">Acinus</a>/<a href="/wiki/Lobe_(anatomy)" title="Lobe (anatomy)">Lobe</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox authority-control" aria-label="Navbox576" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Help:Authority_control" title="Help:Authority control">Authority control databases</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q1425513#identifiers" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" 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