CINXE.COM

<!DOCTYPE html> <html lang="en"> <head>  <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="format-detection" content="telephone=no" /> <meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=0" /> <script> function callIfOrWhenWindowLoaded(func) { if (func != undefined) { if (document.readyState == 'complete' && typeof ($m) !== 'undefined') { func(); } else { if (window.attachEvent) { window.attachEvent('onload', func); } else if (window.addEventListener) { window.addEventListener('load', func, false); } else { document.addEventListener('load', func, false); } } } } </script> <script type="text/javascript"> if (!window.console) console = {log: function() {}, info: function() {}}; </script>  <title> CD45 Monoclonal Antibody (30-F11), PE (12-0451-82) </title> <link rel="preload stylesheet" type="text/css" as="style" href="/order/genome-database/assets/js/angular/dist/gsh/gsh-header-v2.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload stylesheet" type="text/css" as="style" href="/order/genome-database/assets/css/font-common.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="canonical" href="https://www.thermofisher.com/antibody/product/CD45-Antibody-clone-30-F11-Monoclonal/12-0451-82"/> <link rel="alternate" href="https://www.thermofisher.com/antibody/product/CD45-Antibody-clone-30-F11-Monoclonal/12-0451-82" hreflang="en-us"/> <link rel="alternate" href="https://www.thermofisher.cn/cn/zh/antibody/product/CD45-Antibody-clone-30-F11-Monoclonal/12-0451-82" hreflang="zh-cn"/> <link rel="alternate" href="https://www.thermofisher.cn/cn/en/antibody/product/CD45-Antibody-clone-30-F11-Monoclonal/12-0451-82" hreflang="en-cn"/> <link rel="alternate" href="https://www.thermofisher.com/antibody/product/CD45-Antibody-clone-30-F11-Monoclonal/12-0451-82" hreflang="x-default"/>          <meta name="description" content="Invitrogen Anti-CD45 Monoclonal (30-F11), eBioscience™, Catalog # 12-0451-82. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL)." /> <link rel="dns-prefetch" href="//tools.thermofisher.com" /> <link rel="dns-prefetch" href="//downloads.thermofisher.com" /> <link rel="dns-prefetch" href="//assets.thermofisher.com" /> <link rel="preconnect" href="//assets.adobedtm.com" /> <link rel="dns-prefetch" href="//assets.adobedtm.com" />  <meta charset="utf-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="author" content="" /> <meta http-equiv="cache-control" content="no-cache, must-revalidate" /> <meta http-equiv="expires" content="0" /> <meta http-equiv="pragma" content="no-cache" />  <link rel="preload" as="script" href="/etc/designs/lifetech/clientlibs/base-jquery.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload" as="script" href="/etc/designs/lifetech/clientlibs/base-bootstrap.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="preload" as="script" href="/shared-static/scripts/global-variables.js"> <link rel="preload" as="script" href="/shared-static/scripts/global-functions.js">    </head> <body> <script> if (typeof $m === 'undefined' || !$m) { var $m = {}; } $m.basepath = "//" + window.location.host + "/order/genome-database/"; $m.pageName = 'PDP'; $m.curSym = ''; $m.currencyDisplay = ''; $m.lt_rev='VLocal', // Used to defeat caching $m.domainName = 'LT'; $m.portalBaseURL = 'https://www.thermofisher.com/'; $m.keywordTypeaheadBaseURL = 'https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/solr/lt-magellan-search-core/select'; $m.inventoryLocationCountryLists = 'UK-AT-BE-BG-HR-CZ-DK-EE-FI-FR-DE-GB-GR-HU-IS-IE-IL-IT-LT-LU-MT-NL-NO-PL-PT-RO-SK-ES-SE-CH-TR'; $m.isLeadTimeEnabled = false; $m.mapDataServer = 'https://www.thermofisher.com/api/magellan/alignmap/map-server'; $m.CID = ''; $m.ICID = ''; $m.isLoggedIn = false; $m.pluginURLParm = ''; $m.isoLanguage = 'en'; $m.translationEnabledProducts = 'antibody;immunoassay'; $m.buildNumber = 'Local'; $m.buildTimestamp = '2024-11-22T02:34:20+0000'; //TO-DO Update this whenever there is change in strategy for Apple $m.apple = '-apple'; $m.useFisherSciMfgPart = 'false'; $m.useAdobeLaunch = 'true'; </script> <header class="header"> <div class="globalHeader" id="hfGlobalHeader" data-orig="tfpt-header-footer" data-app-env="prod" data-site="tf" data-hostname="www.thermofisher.com" data-x-host="www.thermofisher.com" data-env="prod" data-hash="468bd07150dbbf" data-version="4.03.29" data-analytics-section="header" data-aem-syndication-info="(sg:en-sg:anonymous:https-tf)" data-aem-syndication-timestamp="globalHeader: Wed, 27 Nov 2024 17:21:20 GMT" data-optional-selectors="inlineCss,globalRoute">          <script type="text/javascript"> // define the console object if it is not available as a temporary fix for console.log issues on IE 8 if(!(window.console && console.log)) { console = { log: function(){}, debug: function(){}, info: function(){}, warn: function(){}, error: function(){} }; } </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalHeader:renderBegin"); </script>  <script data-inline-file-name='trust-arc.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/trust-arc.min.js */ window.hfSite="tf",window.trustArc={consentInsights:{api_key:"",secret:""},init:function(e,t,n,r){if(window.trustArc.countryCode=e,window.trustArc.languageCode=t,window.trustArc.ut=window.trustArc.preferences()?"RETURNING":"NEW",window.trustArc.privacyURL=document.location.origin+"/"+e+"/"+t+"/home/global/privacy-policy.html",window.trustArc.cookieURL=document.location.origin+"/"+e+"/"+t+"/home/global/how-cookies-are-used.html","uk"===e&&(e="gb"),"ic"===e&&(e="es"),"br"===e&&"pt"===t&&(t="pt_br"),"zh"===t&&(t="zh_hans"),"zt"===t&&(t="zh_cn"),window.trustArc.CMurl="//consent.truste.com/notice?c=teconsent&pcookie=true&js=nj&gtm=true&noticeType=bb&text=true&domain="+n+"&country="+e+"&language="+t+"&privacypolicylink=",window.trustArc.tagManagerURL=r,window.trustArc.injectCM(),r.indexOf("development")>-1||r.indexOf("staging")>-1?(window.trustArc.consentInsights.api_key="CI-7153680989",window.trustArc.consentInsights.secret="791102116598381495740862696243996077676903892648153044076559127326113493625826883438963034185582914868990705664"):(window.trustArc.consentInsights.api_key="CI-3929813243",window.trustArc.consentInsights.secret="810274278902470721624405905887912991104270295366493143855663183685375235160482241511078341257235422202822656000"),!window.sessionStorage.ciVisitId&&!window.localStorage.consentInsightsVisitRecorded){var s=URL.createObjectURL(new Blob);window.sessionStorage.ciVisitId=s.substring(s.lastIndexOf("/")+1),window.trustArc.sendMetric("visit")}document.body.addEventListener("truste-consent",function(){var e=getCookie("notice_gdpr_prefs");if(window.localStorage.consentInsightsConsentRecorded||window.trustArc.sendMetric("consent"),window.trustArc.tagManagerURL&&!document.querySelector("#tagmanager")&&(e.includes("1")||e.includes("2"))){var t=document.createElement("script");t.id="tagmanager",t.src=window.trustArc.tagManagerURL,t.type="text/javascript",document.head.appendChild(t)}}),setTimeout(function(){var e=document.querySelector("#truste-consent-track");e&&"block"===e.style.display&&window.trustArc.sendMetric("impression")},1e3),window.addEventListener("message",function(e){try{"cm_loading"!==JSON.parse(e.data).message||window.localStorage.consentInsightsImpressionRecorded||window.trustArc.sendMetric("impression")}catch(e){"SyntaxError"!=e.name&&console.log(e)}},!1)},injectCM:function(){var e=document.createElement("script");e.async=!0,e.src=window.trustArc.CMurl+window.trustArc.privacyURL+"&cookieLink="+window.trustArc.cookieURL,e.setAttribute("crossorigin",!0),document.head.appendChild(e)},preferences:function(){return getCookie("notice_gdpr_prefs")},requiredReady:function(){return!0},functionalReady:function(){return window.trustArc.preferences().includes("1")},advertisementReady:function(){return window.trustArc.preferences().includes("2")},enable:function(e){return e||!e&&window.location.href.includes("eta=true")},sendMetric:function(e){var t=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/visits/capture"),n=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/impressions/capture"),r=new URL("https://consent-insights-3c23a978f31a.herokuapp.com/api/v1/consents/capture"),s="";switch(e){case"visit":s=t;break;case"impression":s=n;break;case"consent":s=r}s.searchParams.append("api_key",window.trustArc.consentInsights.api_key),s.searchParams.append("secret",window.trustArc.consentInsights.secret),s.searchParams.append("country",window.trustArc.countryCode),s.searchParams.append("language",window.trustArc.languageCode),s.searchParams.append("visit_id",window.sessionStorage.ciVisitId),s.searchParams.append("ut",window.trustArc.ut),window.trustArc.preferences()&&s.searchParams.append("preferences",window.trustArc.preferences()),s.searchParams.append("ua",navigator.userAgent),s.searchParams.append("title",document.title),s.searchParams.append("url",window.location.href);var i=document.createElement("img");i.src=s,i.alt="1x1 image pixel for data collection",document.body.appendChild(i),"visit"===e&&(window.localStorage.consentInsightsVisitRecorded=!0),"impression"===e&&(window.localStorage.consentInsightsImpressionRecorded=!0),"consent"===e&&(window.localStorage.consentInsightsConsentRecorded=!0)}};</script> <script type="text/javascript"> document.addEventListener("DOMContentLoaded", function(){ if (window.trustArc.enable(true) && !(/how-cookies-are-used|privacy-policy/i.test(window.location.href))) { window.trustArc.init("sg", "en", "thermofisher.com", "https://assets.adobedtm.com/launch-ENeecb77f1160a4928a492ff040f7110c7.min.js"); } }) </script> <script id="inlineHFJavascriptConfig" type="text/javascript"> if ( !window.globalHeaderConfig ) { var globalHeaderConfig = {}; } globalHeaderConfig.logoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png' globalHeaderConfig.scmsEuLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsEuLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/supply-centre.png'; globalHeaderConfig.scmsEuLogoImagePath = '/content/dam/LifeTech/Images/Header/supply-center.png'; globalHeaderConfig.scmsEuLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/supply-centre.png'; globalHeaderConfig.scmsShipToLabLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsShipToLabLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsShipToLabLogoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsShipToLabLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/logo-black.png'; globalHeaderConfig.scmsEuShipToLabLogoLinkHref = 'https://commerce.thermofisher.com/customersite/schome.cfm'; globalHeaderConfig.scmsEuShipToLabLogoImageIe6Path = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsEuShipToLabLogoImagePath = '/content/dam/LifeTech/Images/Header/logo-color.png'; globalHeaderConfig.scmsEuShipToLabLogoImagePrintPath = '/content/dam/LifeTech/Images/Header/logo-black.png'; globalHeaderConfig.scmsNavLinkTextForEU = 'Supply Centre Settings'; globalHeaderConfig.scmsNavUnlockLinkTextForEU = ''; globalHeaderConfig.scmsNavChangeLocationLinkTextForEU = 'Change My Location'; globalHeaderConfig.scmsNavSetStartPageLinkTextForEU = 'Set My Start Page'; globalHeaderConfig.scmsNavSupplyCenterHomeLinkTextForEU = 'Supply Centre Home'; globalHeaderConfig.scmsNavSupplyCenterHomeForLabLinkTextForEU = 'Supply Centre Home'; globalHeaderConfig.utilityBarSignInForwardLinkHref = '/auth/initiate'; </script> <script data-inline-file-name="https://www.thermofisher.com/dm-offers/preload.min.js"> if(!window.preloadOffers){window.preloadOffers={version:"2024.4.0"};function preLoadOffer(e,t,r,o,f){var n=document.querySelector("#"+e+" , ."+e),d,l;if(!n){if(r<25){r++;setTimeout((function(){preLoadOffer(e,t,r,o,f)}),t);return}return}if(o&&preloadVerifyHtmlOffer(o)){try{n.innerHTML=o;l=n.querySelectorAll("script");for(d=0;d<l.length;d++){preloadOffers.scriptNode.push(l[d])}n.setAttribute("preloaded","true");n.setAttribute("offerUrl",f);dispatchPreloadOffersEvent("requestPostEvents")}catch(e){console.error("could not execute script : "+e)}if(!!f&&f.length>1){try{n.querySelector("a").href=f;console.log("in preload added offerUrl",f,"to",e)}catch(t){console.warn("in preload failed to add offerUrl",f,"to",e)}}}else{showDefaultOfferContent(n);n.setAttribute("preloaded-default","true")}}function preloadVerifyHtmlOffer(e){var t=false,r,o;if(typeof e!=="undefined"&&e.length>0){if(e.indexOf("<head")===-1){t=true}else{r=(new DOMParser).parseFromString(e,"text/html");o=r.querySelector("head");if(o.childElementCount===0){t=true}}}return t}function showDefaultOfferContent(e){try{e.setAttribute("preloaded","false");var t=e.querySelector(" .loading-wheel-block"),r=e.querySelector(" .loading-wheel-block .loading-wheel"),o=e.querySelector(" .loading-wheel-block .defaultOffer");t.style.padding="0px";r.remove();o.removeAttribute("style")}catch(t){console.log("Preload offers - no default offer for div :: "+e.getAttribute("id"))}}function processOfferResp(e){if(e){var t=JSON.parse(e),r,o,f;window.preloadOffers.response=t;window.preloadOffers.scriptNode=[];if(t&&t.hasOwnProperty("offerPlacementMap")){r=t["offerPlacementMap"];for(o in r){f=r[o];preLoadOffer(o,100,1,f.offerHTML,f.offerUrl)}}}}function dispatchPreloadOffersEvent(e){if(document.createEvent){var t=document.createEvent("Event");t.initEvent(e,true,true);document.dispatchEvent(t)}else if(document.createEventObject){if(!!document.documentElement[e]){document.documentElement[e]=1}document.documentElement[e]++}}function getCookie(e){var t=e+"=",r=document.cookie,o=r.indexOf(t),f=null,n;if(o!==-1){n=r.indexOf("; ",o);if(n===-1){n=r.length}f=r.slice(o+t.length,n);f=unescape(f)}return f}if(getCookie("cq-authoring-mode")===null){var preloadUrl="/event/offer/preload",xhttp=new XMLHttpRequest;xhttp.onreadystatechange=function(){if(this.readyState===4){if(!window.preloadOffers){window.preloadOffers={}}if(this.status===200){window.preloadOffers.succeed=true;processOfferResp(this.responseText)}else{window.preloadOffers.succeed=false}dispatchPreloadOffersEvent("preloadOffers");window.preloadOffers.status=this.status;window.preloadOffers.statusText=this.statusText}};xhttp.ontimeout=function(){window.preloadOffers.succeed=false;dispatchPreloadOffersEvent("preloadOffers")};xhttp.open("POST",preloadUrl,true);xhttp.setRequestHeader("Content-Type","application/json;charset=UTF-8");xhttp.timeout=4e3;xhttp.send()}} </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_0"); </script>  <style data-inline-file-name='header.min.css' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/css/dist/header.min.css */ @charset "UTF-8";@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:lighter;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:100;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:200;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:300;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.woff2) format("woff2");font-weight:400;font-style:italic;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:500;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:600;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:800;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:900;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}body.overflow-hidden{overflow:hidden;position:fixed;width:100%}#recommendation-overlay-content{margin-top:16px}.border-bottom{border-bottom:1px solid #dcdcdc}.hidden{display:none}.loading-wheel-sm.hidden{display:none}.contents{margin:0 auto}.pdp-alert .pdp-banners{z-index:9004}.pdp-main{padding-top:10px}.pdp-main .c-section{margin-top:0}.headerMiddleContent{width:100%;flex-grow:3;flex-shrink:1;flex-basis:100%}#header-offer-bar{position:relative;background:#fff;z-index:81}header .dm-dynamic-offer.dm-img-bkg.cmp-teaser{border:none;position:inherit}header .main-header-container .info-container ul li.account .create-account .loyalty-text{font-weight:700}header .main-header-container .info-container ul li.account .create-account .loyalty-text a{color:#222;font-size:14px;line-height:22px}header .info-container #notification-dd .c-loader{margin:125px 200px}header .info-container #cart-sidebar .c-loader{margin:300px 200px}body.has-messaging-bar header{top:35px}.header-separator{height:0}header{width:100%;border-bottom:1px solid #dcdcdc;position:fixed;background-color:#fff;font-size:14px;line-height:22px;top:0;left:0;right:0;z-index:80}header #dr-activity-banner{background:#fff;color:red;background-color:#ff0;font-weight:600;width:100%;font-size:12px;text-align:center;z-index:80;border-bottom:1px solid #ccc;top:0;left:0;right:0}header #dr-activity-banner .dr-activity-message{display:inline-block;padding:0 2px}header #messagingBar{background:#fff;color:#666;width:100%;line-height:35px;height:35px;font-size:15px;text-align:left;z-index:80;border-bottom:1px solid #ccc;top:0;left:0;right:0;position:fixed}header #messagingBar .messaging-bar-snippet{overflow:auto;display:inline-block;padding:0 2px}header #messagingBar .messaging-bar-snippet img{height:24px;width:auto;margin-top:-2px}header #messagingBar .container{width:1408px}header .main-header-container{max-width:1440px;margin:auto;padding:0 24px;display:flex;align-items:center;justify-content:center;height:60px;position:relative}header .scms-container{max-width:1440px;margin:auto;padding:8px 24px 0;line-height:26px;color:#70707a}header .scms-container span{padding-right:12px;margin-right:6px;border-right:#222 solid 1px}header .nav-container{margin-left:auto;display:flex;align-self:center;min-width:186px;flex-grow:1;flex-shrink:1;flex-basis:0;transition:min-width .2s ease;padding:0;background:#fff}header .nav-container span:focus-visible{outline:2px solid #802eff}header .nav-container .hamburger-btn{position:relative;width:32px;height:32px;margin-right:18px;margin-top:12px;border:3px solid #fff}header .nav-container .hamburger-btn .icon{position:absolute;height:3px;width:24px;top:12px;left:1px;background-color:#222;display:inline-block}header .nav-container .hamburger-btn .icon:before{transition-duration:.5s;position:absolute;width:24px;height:3px;background-color:#222;content:"";top:-8px}header .nav-container .hamburger-btn .icon:after{transition-duration:.5s;position:absolute;width:24px;height:3px;background-color:#222;content:"";top:8px}header .nav-container .hamburger-btn:hover{cursor:pointer}header .nav-container .hamburger-btn:focus-visible{outline:2px solid #802eff}header .nav-container .logo{width:fit-content;height:fit-content}header .nav-container .logo:focus-visible{outline:2px solid #802eff}header .nav-container .logo svg{width:114px;margin-top:-2px}header .nav-container .logo img{max-width:117px;width:100%;max-height:42px;height:auto;margin-top:12px;margin-left:-8px}header .nav-container .mega-nav{background-color:#fff;padding:0 54px;position:fixed;top:0;left:0;bottom:0;visibility:hidden;transform:translate(-110%);z-index:998;transition:.5s;max-width:380px;overflow:auto;width:100%}header .nav-container .mega-nav.open .account-dd{display:none}header .nav-container .mega-nav.open .sign-out{display:none}header .nav-container .mega-nav .main-nav,header .nav-container .mega-nav .sign-out,header .nav-container .mega-nav .support{display:block}header .nav-container .mega-nav .create-account .display-4{display:inline-block}header .nav-container .mega-nav.account-open .main-nav,header .nav-container .mega-nav.account-open .sign-out,header .nav-container .mega-nav.account-open .support{display:none}header .nav-container .mega-nav.account-open .create-account .display-4{display:none}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details{display:inline-block}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details ul{padding-inline-start:0}header .nav-container .mega-nav.account-open .account-dd #sidenav-account-details ul li a{padding-top:16px;font-weight:400;font-size:16px;line-height:26px;color:#1b1b1d}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount a{font-weight:500;font-size:22px;line-height:28px;color:#222;position:relative}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow{width:16px;position:absolute;left:-32px;top:12px;display:inline-block;height:2px;background-color:#222}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::after,header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::before{content:"";position:absolute;width:12px;height:2px;left:-1px;background-color:#222;z-index:-1}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::after{top:-4px;transform:rotate(-45deg)}header .nav-container .mega-nav.account-open .account .create-account .sidenav-myaccount .arrow::before{top:4px;transform:rotate(45deg)}header .nav-container .mega-nav .close{top:24px;right:24px}header .nav-container .mega-nav .close:hover{cursor:pointer}header .nav-container .mega-nav a{text-decoration:none;color:#222;display:block}header .nav-container .mega-nav a:active,header .nav-container .mega-nav a:hover{text-decoration:underline;cursor:pointer}header .nav-container .mega-nav .account{margin-top:36px}header .nav-container .mega-nav .account .user-name{font-weight:100;font-size:30px;line-height:38px;color:#2b2b30;margin-bottom:29px}header .nav-container .mega-nav .account .my-account{font-weight:400;font-size:16px;line-height:26px;padding-bottom:12px;color:#1b1b1d}header .nav-container .mega-nav .account .create-account{padding:14px 0}header .nav-container .mega-nav .account .create-account li{padding-bottom:16px}header .nav-container .mega-nav .account .create-account .sidenav-myaccount a{font-weight:400;font-size:16px;color:#1b1b1d}header .nav-container .mega-nav .account .create-account a{font-weight:400;font-size:14px;line-height:26px;padding-bottom:16px;display:inline;color:#0071d0}header .nav-container .mega-nav .account .create-account ul{list-style:none;margin:0}header .nav-container .mega-nav .account .create-account.open .my-account-text{font-weight:500;font-size:22px;line-height:28px}header .nav-container .mega-nav .main-nav{font-weight:500;font-size:22px;line-height:28px;list-style-type:none;margin-left:0;padding-inline-start:0;margin-block-start:0;margin-top:0}header .nav-container .mega-nav .main-nav-item{padding:16px 0;line-height:22px}header .nav-container .mega-nav .main-nav-item.create-account{margin-top:-45px}header .nav-container .mega-nav .main-nav-item.create-account .arrow{display:none}header .nav-container .mega-nav .main-nav-item.create-account .title{font-weight:400;font-size:16px;line-height:26px}header .nav-container .mega-nav .main-nav-item a:active,header .nav-container .mega-nav .main-nav-item a:visited{color:#54545c}header .nav-container .mega-nav .main-nav-item:hover{cursor:pointer}header .nav-container .mega-nav .main-nav-item.open{padding:0 36px;margin-left:-36px;margin-top:24px;padding-right:0;padding-bottom:14px}header .nav-container .mega-nav .main-nav-item.open .arrow{width:16px;position:absolute;left:16px;top:90px;display:inline-block;height:2px;background-color:#222}header .nav-container .mega-nav .main-nav-item.open .arrow::after,header .nav-container .mega-nav .main-nav-item.open .arrow::before{content:"";position:absolute;width:12px;height:2px;left:-1px;background-color:#222;z-index:-1}header .nav-container .mega-nav .main-nav-item.open .arrow::after{top:-4px;transform:rotate(-45deg)}header .nav-container .mega-nav .main-nav-item.open .arrow::before{top:4px;transform:rotate(45deg)}header .nav-container .mega-nav .sub-nav{transform:translate(0,0);animation:delayedFadeIn .4s;visibility:hidden;display:none;font-weight:400;font-size:16px;line-height:42px;list-style-type:none;padding-inline-start:0;position:absolute;background-color:#fff;margin:24px 24px 24px 0;padding-right:24px;z-index:-1;padding-bottom:42px}header .nav-container .mega-nav .sub-nav li a{line-height:22px;padding:10px 0}header .nav-container .mega-nav .sub-nav .popular-image{height:74px;width:112px;object-fit:cover;display:inline-block}header .nav-container .mega-nav .sub-nav .see-all{margin-bottom:36px;position:absolute;color:#0071d0!important;max-width:290px}header .nav-container .mega-nav .sub-nav .see-all a{color:inherit}header .nav-container .mega-nav .sub-nav .see-all .right-arrow{position:absolute;height:3px;width:16px;bottom:18px;margin-left:15px;background-color:#0071d0}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::after,header .nav-container .mega-nav .sub-nav .see-all .right-arrow::before{content:"";position:absolute;width:11px;height:3px;right:-4px;background-color:#0071d0}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::after{top:-3px;transform:rotate(45deg)}header .nav-container .mega-nav .sub-nav .see-all .right-arrow::before{top:3px;transform:rotate(-45deg)}header .nav-container .mega-nav .sign-out{margin-bottom:142px;margin-top:24px}header .nav-container .mega-nav .sign-out a{color:#0071d0}header .nav-container .mega-nav.open .account{overflow:hidden;animation:fadeIn .5s}header .nav-container .mega-nav.open li{display:none}header .nav-container .mega-nav.open li.open{display:block}header .nav-container .mega-nav.open li.open .sub-nav{visibility:visible;display:block;animation:delayedFadeIn 1.2s ease-in}header .nav-container .mega-nav.open li.open .sub-nav li{display:block}header .nav-container .mega-nav.open li.open .sub-nav li.popular{display:flex;align-items:center}header .nav-container .mega-nav.open .main-nav{border-bottom:1px solid #dcdcdc;padding-left:36px;margin-left:-36px}header .nav-container .mega-nav .support{font-weight:400;font-size:16px;line-height:26px;list-style-type:none;margin-left:0;margin-top:0;padding-inline-start:0;margin-block-end:0;max-width:280px}header .nav-container .mega-nav .support li{margin-top:16px}header .nav-container.open .mega-nav{transform:translate(0);visibility:visible;box-shadow:0 18px 18px rgba(0,0,0,.3)}header .search-container{align-self:center;padding:16px;display:flex;position:relative;width:100%}header .search-container .search-layout{padding:16px 36px;width:100%;display:none}header .search-container .search .search-button{border-radius:0 3px 3px 0;margin:0;text-align:center;filter:none;outline:0;border:none;height:50px;width:100px;background:#4a4a4a}header .search-container .search .search-button:hover{cursor:pointer}header .search-container .search-icon{width:30px;position:absolute;right:12px;top:4px}header .search-container .search-icon:hover{cursor:pointer}header .search-container .search-icon .cls-1{fill:#54545c}header .search-container.open .search{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;top:0;left:0;height:100%;width:100%;background-color:#fff;animation:fadeIn .5s}header .search-container.open .search-layout{padding:16px 36px;display:block}header .search-container .close{display:none}header .info-container{position:relative;width:auto;opacity:1;flex-grow:1;flex-shrink:1;flex-basis:0}header .info-container a{color:#222;cursor:pointer}header .info-container ul{list-style-type:none;display:flex;padding-inline-start:0;align-items:center;justify-content:center;margin:0}header .info-container ul li{display:inline-block;padding:0 12px;width:max-content}header .info-container ul li.order-status{display:none}header .info-container ul li.quick-order{display:none}header .info-container ul li.cart{margin-right:-16px}header .info-container ul li.cart a{height:42px;width:42px;display:inline-block;margin-left:-2px}header .info-container ul li.cart a svg{height:32px;width:32px;display:inline-block}header .info-container ul li.bell,header .info-container ul li.cart{width:52px;margin-bottom:-10px;position:relative}header .info-container ul li.bell:hover,header .info-container ul li.cart:hover{cursor:pointer}header .info-container ul li.bell.active,header .info-container ul li.cart.active{border-bottom:3px solid #e71316;margin-bottom:-13px}header .info-container ul li.bell a:focus,header .info-container ul li.cart a:focus{outline:0}header .info-container ul li.bell .cls-1,header .info-container ul li.cart .cls-1{fill:#54545c}header .info-container ul li.bell .alert,header .info-container ul li.cart .alert{border-radius:50%;background-color:#e71316;border:#fff solid 1px;position:absolute;display:inline-block;height:12px;width:12px;right:12px;padding:0}header .info-container ul li.bell .count,header .info-container ul li.cart .count{color:#e71316;font-size:11px;font-weight:700;position:absolute;display:inline-block;right:19px;top:-11px}header .info-container ul li.bell{margin-bottom:-8px}header .info-container ul li.account{display:none;position:relative;margin-bottom:-2px}header .info-container ul li.account:hover{cursor:pointer}header .info-container ul li.account.open::after{content:" ";position:absolute;bottom:-3px;height:3px;background-color:#e71316;width:100%;left:0;z-index:83}header .info-container ul span#logged-in-toggle::after,header .info-container ul span#sign-in-toggle::after{content:"▼";font-size:8px;margin-left:6px;display:inline-block;color:#54545c}header .info-container .cart-dd{transform:translate(110%);transition:.5s;visibility:hidden;position:fixed;z-index:1000;background-color:#fff;right:0;top:0;width:100%;height:100%;max-width:440px;overflow-y:scroll;padding:32px 24px;overscroll-behavior:contain}header .info-container .cart-dd-header{font-weight:500;font-size:22px;line-height:28px;color:#1b1b1d}header .info-container .cart-dd-header .close{right:16px;top:24px}header .info-container .cart-dd-body .lable{margin-top:32px;font-weight:500;font-size:18px;line-height:22px}header .info-container .cart-dd-body .product{font-weight:400;margin-top:24px}header .info-container .cart-dd-body .product .image{height:50px;width:50px;background-color:#a2a2a2;display:inline-block;float:left}header .info-container .cart-dd-body .product .info{width:100%;padding-left:66px;font-weight:400}header .info-container .cart-dd-body .product .info .title a{font-weight:400;font-size:14px;line-height:20px;color:#0071d0}header .info-container .cart-dd-body .product .info .bold{font-weight:600}header .info-container .cart-dd-body .product .info .contactUsLink{color:#0071d0}header .info-container .cart-dd-body .product .info .special-offer-wrapper{margin-top:8px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .finalPrice{font-size:16px;font-weight:500}header .info-container .cart-dd-body .product .info .special-offer-wrapper .strikeThroughPrice{margin-left:5px;color:#70707a}header .info-container .cart-dd-body .product .info .special-offer-wrapper .absoluteSave{color:#01891e;font-weight:500;font-size:12px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .specialOfferEndDate{color:#70707a;font-weight:500;font-size:12px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip{position:relative;display:inline-block}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .icon-wrapper{display:inline-block;margin-left:5px}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext{display:block;visibility:hidden;position:absolute;top:100%;left:50%;transform:translate(-50%,10px);width:max-content;max-width:220px;background-color:#fff;border:1px solid #ddd;border-radius:3px;color:#000;padding:10px;text-align:center;z-index:1;opacity:0;transition:opacity .3s;box-shadow:0 6px 8px 0 rgba(13,13,13,.1)}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext::before{content:"";position:absolute;top:-9px;left:calc(50% - 5px);border-left:1px solid #ddd;border-top:1px solid #ddd;transform:rotate(45deg);width:16px;height:16px;background:#fff}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip .tooltiptext .signInLink{color:#0071d0}header .info-container .cart-dd-body .product .info .special-offer-wrapper .tooltip:hover .tooltiptext{visibility:visible;opacity:1}header .info-container .cart-dd-footer .subtotal{font-weight:500;font-size:18px;line-height:28px}header .info-container .cart-dd-footer .price{font-weight:200;font-size:22px}header .info-container .cart-dd-footer a{display:inline-block;color:#0071d0}header .info-container .cart-dd-footer .offer{box-shadow:0 2px 4px rgba(34,34,34,.1)}header .info-container .cart-dd-footer .offer #recommendation-overlay{position:fixed;display:none;background:#fff;top:0;padding:16px;right:0;left:0;z-index:1;height:100vh;min-height:1200px}header .info-container .cart-dd-footer .offer #recommendation-overlay.open{display:block}header .info-container .cart-dd-footer .offer #recommendation-overlay .back{font-weight:500;font-size:14px;line-height:22px;color:#0071d0;margin-bottom:24px;padding-left:18px}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow{width:12px;position:absolute;left:16px;top:26px;display:inline-block;height:2px;background-color:#0071d0}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::after,header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::before{content:"";position:absolute;width:9px;height:2px;left:-1px;background-color:#0071d0;z-index:-1}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::before{top:3px;transform:rotate(45deg)}header .info-container .cart-dd-footer .offer #recommendation-overlay .back .arrow::after{top:-3px;transform:rotate(-45deg)}header .info-container .cart-dd-footer .offer #recommendation-overlay .back:hover{cursor:pointer}header .info-container .cart-dd-footer .offer #recommendation-overlay a.button.btn-featured{color:#fff;line-height:40px;padding:0 16px;background-color:#e71316;border:1px solid #e71316;border-radius:3px}header .info-container .cart-dd-footer .suggested-products{background-color:#f7f7f7;padding:24px;margin:0 -24px}header .info-container .cart-dd-footer .suggested-products .title{font-weight:400;font-size:16px;line-height:20px;margin-bottom:16px}header .info-container .cart-dd-footer .suggested-products .product{background:#fff;border:1px solid #e5e5e5;border-radius:3px;padding:16px}header .info-container .cart-dd-footer .suggested-products .product .line{display:flex;align-items:center;justify-content:space-between;flex-direction:row}header .info-container .cart-dd-footer .suggested-products .product .line .image{width:50px;height:auto}header .info-container .cart-dd-footer .suggested-products .product .line .image img{max-width:100%;max-height:100%}header .info-container .cart-dd-footer .suggested-products .product .line .label{padding:0 16px;font-weight:700;font-size:14px;line-height:22px;color:#008ceb;width:100%;white-space:inherit;background-color:#fff}header .info-container .cart-dd-footer .suggested-products .product .line .qty{min-width:80px;text-align:right}header .info-container .cart-dd-footer .suggested-products .product .line .qty span{font-weight:400;font-size:14px;line-height:12px;text-align:center;color:#54545c;padding-right:8px}header .info-container .cart-dd-footer .suggested-products .product .line .qty input{background:#fff;border:1px solid #dcdcdc;border-radius:3px;width:34px;height:34px}header .info-container .cart-dd-footer .suggested-products .product .description{font-weight:400;font-size:12px;line-height:15px;color:#61616b;padding:4px 0}header .info-container .cart-dd-footer .suggested-products .product .info{display:flex;justify-content:space-between}header .info-container .cart-dd-footer .suggested-products .product .info .price{font-weight:200;font-size:14px;line-height:22px}header .info-container .cart-dd-footer .suggested-products .product .info .cmp-p-ctaitem{margin-top:-12px}header .info-container .cart-dd-footer .suggested-products .product .info .cmp-p-ctaitem.m--small .cmp-ctaitem{padding:0 16px}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem .shopping--btn{color:#0071d0;width:100%;display:block}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem__anchor{width:100%}header .info-container .cart-dd-footer .cmp-p-ctaitem.m--block .cmp-ctaitem{padding:0}header .info-container .cart-dd .float-right{float:right}header .info-container .cart-dd .no-product{text-align:center;color:#000;padding:72px 0}header .info-container .cart-dd.open{transform:translate(0);visibility:visible}header .info-container .bell-dd{overflow-y:scroll;box-shadow:0 4px 6px rgba(0,0,0,.1);background-color:#fff;overscroll-behavior:contain}header .info-container .bell-dd a{color:#0071d0}header .info-container .bell-dd-header{font-weight:500;font-size:22px;line-height:28px;padding:63px 36px 16px;border-bottom:1px solid #dcdcdc;background-color:#fff}header .info-container .bell-dd-header a{font-weight:400;font-size:14px;line-height:22px;display:inline;float:right;padding-top:4px}header .info-container .bell-dd-body .notification{padding:36px 36px 36px;font-weight:200;font-size:14px;line-height:22px;border-bottom:1px solid #dcdcdc;background-color:#fff}header .info-container .bell-dd-body .notification .body{position:relative}header .info-container .bell-dd-body .notification.new{background-color:#f7f7f7}header .info-container .bell-dd-body .notification .label{font-weight:700;font-size:12px;line-height:22px;color:#81828c;padding:0 0 6px 0;display:block;background-color:transparent}header .info-container .bell-dd-body .notification .time{font-weight:400;font-size:12px;line-height:22px;float:right}header .info-container .bell-dd-body .notification a{display:inline}header .info-container .bell-dd-body .notification a .label:hover{text-decoration:none}header .info-container .bell-dd-body .notification a .body{padding-right:30px;position:relative;color:#1b1b1d}header .info-container .bell-dd-body .notification a .body:hover{color:#0071d0;text-decoration:underline;cursor:pointer}header .info-container .bell-dd-body .notification .bin{width:20px;position:absolute;top:0;right:0;fill:#92929e}header .info-container .bell-dd-footer{font-weight:500;font-size:14px;line-height:22px}header .info-container .bell-dd.open{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;height:100%;width:100%;top:0;left:0;right:0;animation:fadeIn .5s}header .bell-dd,header .search{display:none;visibility:hidden;opacity:0}header .account-dd #sidenav-account-details{display:none}header .account-dd .open #sidenav-account-details{display:inline-block}header .close{position:absolute;right:36px;top:20px;width:42px;height:42px;opacity:1}header .close:hover{opacity:.5}header .close:before{transform:rotate(45deg)}header .close:after{transform:rotate(-45deg)}header .close:after,header .close:before{position:absolute;left:20px;content:" ";height:24px;width:3px;background-color:#1b1b1d;transition:visibility 0s,opacity .5s linear}header.open .full-bg{opacity:1;visibility:visible;display:block}header .full-bg{opacity:0;visibility:hidden;display:none;position:fixed;content:"";z-index:81;top:0;left:0;width:100%;height:100%;background-color:rgba(0,0,0,.5);transition:visibility 0s,opacity .5s linear}header .full-bg.open{opacity:1;visibility:visible;display:block}header .full-bg.open-top{top:112px}header .search-bg{opacity:0;visibility:hidden;display:none;position:fixed;content:"";z-index:81;left:0;width:100%;height:100%;background-color:rgba(0,0,0,.5);transition:visibility 0s,opacity .5s linear}header .search-bg.open{opacity:1;visibility:visible;display:block}header .c-alert{position:relative;display:inline-block;padding:24px 16px 24px 42px;color:#222;border:1px solid #dcdcdc;margin-top:32px}header .c-alert--warning{border-left:8px solid #f76c1f}header .c-alert__title{font-size:16px;padding-right:6px;font-weight:900}header .c-alert__desc{font-size:16px}header .c-alert__icon{width:24px;height:24px;position:absolute;left:12px}header a:hover{text-decoration:underline}@media (min-width:576px){header .info-container .bell-dd-header{padding:63px 76px 16px}header .info-container .bell-dd-body .notification{padding:36px 76px 36px}}@media (min-width:768px){header .info-container .bell-dd-header{padding:63px 146px 16px}header .info-container .bell-dd-body .notification{padding:36px 146px 36px}}@media (min-width:992px){header.project-header{z-index:0}header .main-header-container{height:76px}header .main-header-container .nav-container .mega-nav .close{top:24px;right:24px}header .main-header-container .search-container .search-layout{margin-right:0}header .main-header-container .info-container{width:100%}header .main-header-container .info-container ul li.order-status{display:inline-block}header .main-header-container .info-container ul li.quick-order{display:inline-block}header .main-header-container .info-container ul li.account{display:inline-block}header .main-header-container .info-container ul li.account .sing-out a{color:#0071d0}header .main-header-container .info-container ul li.account .create-account .loyalty-text{font-weight:700}header .main-header-container .info-container ul li.account .create-account .loyalty-text a{color:#222;font-size:14px;line-height:22px}header .main-header-container .info-container ul li.account .create-account a{display:inline;color:#0071d0}header .main-header-container .info-container ul li.account .create-account ul li a{color:#1b1b1d}header .main-header-container .info-container ul li.account .create-account .sing-out a{color:#0071d0}header .main-header-container .info-container ul li.account .create-account .points{margin-top:-10px}header .main-header-container .info-container ul li.account .create-account .points a{color:#70707a;font-size:14px;line-height:22px}header .main-header-container .info-container ul li.account.open .account-dd{display:inline-block;padding:36px;top:27px;right:-2px;height:auto;overflow-y:scroll;max-height:80vh;overflow-x:hidden;overscroll-behavior:contain}header .main-header-container .info-container ul li.account.open .account-dd ul{display:block;padding-left:0;font-size:16px;line-height:26px;margin-left:-10px}header .main-header-container .info-container ul li.account.open .account-dd ul li{padding-top:8px;display:block;width:auto}header .main-header-container .info-container ul li.account.active{border-bottom:3px solid #e71316;margin-bottom:-7px}header .main-header-container .info-container ul li.cart{margin-right:-16px}header .main-header-container .search .close{opacity:0}header .main-header-container.open .info-container{width:0;opacity:0;flex-grow:0}header .main-header-container.open .info-container ul{pointer-events:none}header .main-header-container.open .nav-container{min-width:152px;transition:min-width .2s ease}header .main-header-container.open .nav-container .menu{width:0}header .main-header-container.open .nav-container .menu .icon{display:none}header .main-header-container.open .search-container{width:100%;margin-right:48px}header .main-header-container.open .search-layout{margin-right:32px}header .main-header-container.open .close{display:inline-block;position:absolute;right:0;animation:delayedFadeIn .7s;opacity:1;z-index:1001;padding:10px;margin-left:5px}header .main-header-container.open .close:hover{opacity:.5;cursor:pointer}header .main-header-container.open .close:focus-visible{outline:2px solid #802eff}header .nav-container .logo svg{width:136px;height:76px;margin-top:-8px}header .nav-container .logo svg .tf-logo-cls-1{fill:#e71316}header .nav-container .logo svg .tf-logo-cls-2{fill:#fff}header .nav-container .logo img{max-width:140px;width:100%;max-height:46px;height:auto;margin-top:12px;margin-left:0}header .nav-container .logo .scms{margin-top:10px;width:150px;margin-left:-8px}header .nav-container .hamburger-btn{margin-top:20px}header .nav-container .mega-nav{padding:0 74px 0 74px;overflow-x:hidden;min-width:380px}header .nav-container .mega-nav span:focus-visible{outline:2px solid #802eff}header .nav-container .mega-nav .main-nav{margin-top:24px}header .nav-container .mega-nav .main-nav-item{display:block;width:308px}header .nav-container .mega-nav .main-nav-item:hover{color:#005daa}header .nav-container .mega-nav .main-nav-item.open{border-bottom:1px solid #dcdcdc;border-top:1px solid #dcdcdc;background-color:#fff;display:block;padding:15px 0;margin-left:0;margin-top:0;padding-right:16px;padding-bottom:14px}header .nav-container .mega-nav .main-nav-item.open::after{content:"";display:block!important;position:absolute;top:0;right:0;border-right:2px solid #fff;height:100%}header .nav-container .mega-nav .main-nav-item.open .sub-nav{left:380px;top:36px;background-color:#fff;padding:0 42px;border-left:1px solid #dcdcdc;visibility:visible;transform:translate(0);display:block;margin-left:0;padding-bottom:42px}header .nav-container .mega-nav .main-nav-item.open .sub-nav li{display:block}header .nav-container .mega-nav .main-nav-item.open .arrow,header .nav-container .mega-nav .main-nav-item.open::after,header .nav-container .mega-nav .main-nav-item.open::before{display:none}header .nav-container .mega-nav .main-nav-item.open .main-nav{border-bottom:none;padding-left:0;margin-left:0}header .nav-container .mega-nav.open{min-width:760px}header .nav-container .mega-nav.open li{display:block}header .nav-container .mega-nav.open .account{max-height:0;transition:max-height .15s ease-out;overflow:hidden;animation:fadeIn .5s}header .nav-container .mega-nav.open .main-nav{border-bottom:none;width:340px}header .nav-container .mega-nav.close .pragma-toggle:hover{cursor:pointer}header .nav-container .mega-nav.close:hover{cursor:pointer}header .nav-container .mega-nav .account{display:none}header .nav-container .mega-nav .support .dt-hide{display:none}header .nav-container .mega-nav .sign-out{border-top:none}header .nav-container .mega-nav .sign-out a{display:none}header .nav-container .mega-nav .logo img{margin-top:32px;max-width:142px;margin-left:0}header .info-container .bell-dd{border:1px solid #d8d8d8;border-radius:4px;background-color:#fff}header .info-container .bell-dd-header{padding:18px 26px 16px 28px;color:#1b1b1d}header .info-container .bell-dd-header .close{display:none}header .info-container .bell-dd-body .notification{padding:24px;font-size:14px;line-height:22px;font-weight:400}header .info-container .bell-dd-body .notification .label{color:#54545c}header .info-container .bell-dd-body .notification .body{color:#1b1b1d;position:relative}header .info-container .bell-dd-body .notification.new:hover .body{color:#0071d0;text-decoration:underline;cursor:pointer}header .info-container .bell-dd-footer{padding:24px}header .info-container .bell-dd.open{position:absolute;top:36px;left:auto;right:32px;height:auto;max-height:calc(100vh - 140px);width:420px}header .info-container .account-dd{position:absolute;width:330px;background:#fff;border:1px solid #d8d8d8;box-sizing:border-box;box-shadow:0 4px 6px rgba(0,0,0,.1);border-radius:4px;display:none;z-index:999}header .info-container .account-dd .account{padding-left:0;padding-right:0;text-align:left}header .info-container .account-dd .create-account .display-4{word-break:break-all;border-bottom:1px solid #dcdcdc}header .search-container{align-self:center;position:relative;transition:1s}header .search-container .search{display:block;visibility:visible;opacity:1;width:100%;padding:0;height:50px}header .search-container .search-layout{display:flex;padding:0}header .search-container .search-icon{display:none}header .account-dd #sidenav-account-details{display:inline-block}header .search-bg{top:96px}header body.has-messaging-bar{top:112px}}@media (prefers-reduced-motion){.hamburger-btn{animation:none!important}.logo{animation:none!important}}.mega-nav{animation:none!important}@keyframes fadeIn{0%{opacity:0;display:none}100%{opacity:1;display:block}}@keyframes fadeOut{0%{opacity:1}100%{opacity:0}}@keyframes delayedFadeIn{0%{display:none;opacity:0}80%{display:block;opacity:1}}.sr-only{display:none}#notification-body .body{position:relative}#notification-body .content{padding:0 20px 0 0!important;display:inline-block}footer,header{font-family:HelveticaNeue,sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;max-width:100%;scroll-behavior:smooth;color:#1b1b1d;margin:0}footer *,header *{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :after,footer :before,header :after,header :before{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :focus-visible,header :focus-visible{outline:2px solid #802eff}footer input:focus-visible,header input:focus-visible{outline:0}footer .bold-label,header .bold-label{font-weight:700}footer .h1,footer .h2,footer .h3,footer .h4,footer .h5,footer .h6,footer body,footer h1,footer h2,footer h3,footer h4,footer h5,footer h6,header .h1,header .h2,header .h3,header .h4,header .h5,header .h6,header body,header h1,header h2,header h3,header h4,header h5,header h6{color:#222}footer .text-light,footer .text-light .display-1,footer .text-light .display-2,footer .text-light .display-3,footer .text-light .display-4,footer .text-light .h1,footer .text-light .h2,footer .text-light .h3,footer .text-light .h4,footer .text-light .h5,footer .text-light .h6,footer .text-light body,footer .text-light h1,footer .text-light h2,footer .text-light h3,footer .text-light h4,footer .text-light h5,footer .text-light h6,header .text-light,header .text-light .display-1,header .text-light .display-2,header .text-light .display-3,header .text-light .display-4,header .text-light .h1,header .text-light .h2,header .text-light .h3,header .text-light .h4,header .text-light .h5,header .text-light .h6,header .text-light body,header .text-light h1,header .text-light h2,header .text-light h3,header .text-light h4,header .text-light h5,header .text-light h6{color:#fff}footer body,header body{margin:0;font-size:16px;line-height:26px}footer p,header p{margin-top:0;margin-bottom:0;font-size:16px;line-height:26px}footer .p-grey,header .p-grey{color:#54545c}footer .text-center,header .text-center{text-align:center}footer .alt,header .alt{font-size:16px;line-height:26px}footer .text-size-14,header .text-size-14{font-size:14px;line-height:22px}footer a,header a{text-decoration:none;color:#1b1b1d}footer a:hover,header a:hover{text-decoration:none;color:#1b1b1d}footer a:visited,header a:visited{text-decoration:none;color:#1b1b1d}footer .disabled,header .disabled{color:#a2a2a2}footer .label-medium,header .label-medium{color:#222;font-size:16px;line-height:26px;font-weight:400}footer .label-bold,header .label-bold{color:#222;font-size:16px;line-height:26px;font-weight:bolder}footer .hint,header .hint{font-size:14px;line-height:30.727268px}footer .blockquote,header .blockquote{color:#222;font-size:20.571424px;line-height:33.090902px;margin-bottom:0}footer .alt-color,header .alt-color{color:#54545c}footer .success,header .success{color:#3bad2f}footer .warning,header .warning{color:#ed7700}footer .error,header .error{color:#e71316}footer .thin,header .thin{font-weight:lighter}footer .light,header .light{font-weight:300}footer .italic,header .italic{font-style:italic}footer .medium,header .medium{font-weight:700}footer .bold,header .bold{font-weight:bolder}footer .h1,footer .h2,footer .h3,footer .h5,footer h1,footer h2,footer h3,footer h5,header .h1,header .h2,header .h3,header .h5,header h1,header h2,header h3,header h5{font-weight:400;margin:0;padding-bottom:10px}footer .h4,footer h4,header .h4,header h4{font-weight:600;margin:0;padding-bottom:10px}footer .h6,footer h6,header .h6,header h6{font-weight:400;margin:0;padding-bottom:10px}footer .display-1,footer .display-2,footer .display-3,footer .display-4,header .display-1,header .display-2,header .display-3,header .display-4{font-family:HelveticaNeueLight,Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-weight:lighter}footer .h1,footer h1,header .h1,header h1{font-size:32px;line-height:40px}footer .h2,footer h2,header .h2,header h2{font-size:26px;line-height:33px}footer .h3,footer h3,header .h3,header h3{font-size:22px;line-height:28px}footer .h4,footer h4,header .h4,header h4{font-size:20px;line-height:25px}footer .h5,footer h5,header .h5,header h5{font-size:18px;line-height:23px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}@media (max-width:768px){footer .h1,footer h1,header .h1,header h1{font-size:26px;line-height:33px}footer .h2,footer h2,header .h2,header h2{font-size:21px;line-height:26px}footer .h3,footer h3,header .h3,header h3{font-size:18px;line-height:23px}footer .h4,footer h4,header .h4,header h4{font-size:16px;line-height:20px}footer .h5,footer h5,header .h5,header h5{font-size:16px;line-height:20px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}}footer .font-size-14,header .font-size-14{font-size:14px}footer .font-size-16,header .font-size-16{font-size:16px}footer .font-size-18,header .font-size-18{font-size:18px}footer .font-size-20,header .font-size-20{font-size:20px}footer .font-size-22,header .font-size-22{font-size:22px}footer .font-size-24,header .font-size-24{font-size:24px}footer .font-size-26,header .font-size-26{font-size:26px}footer fieldset,header fieldset{display:block;margin-inline-start:0;margin-inline-end:0;padding-block-start:0;padding-inline-start:0;padding-inline-end:0;padding-block-end:0;border-width:0;border-style:none}@media print{footer .cmp-p-pageheadinghero,header .cmp-p-pageheadinghero{display:none}footer .cmp-p-manualnav,header .cmp-p-manualnav{display:none}footer .header-cmp,header .header-cmp{display:none}footer .cmp-p-anchorlist,header .cmp-p-anchorlist{display:none}footer .cmp-p-ctaitem,header .cmp-p-ctaitem{display:none}footer .footer,header .footer{display:none}footer .cmp-p-testimonial,header .cmp-p-testimonial{display:none}footer td,footer th,header td,header th{padding-top:4px;padding-bottom:4px;height:30px}}.cmp-ctaitem{margin-top:16px}.cmp-ctaitem__anchor{display:block;color:#0071d0;font-weight:700;font-size:18px}.cmp-ctaitem__anchor:hover{color:#005daa}.cmp-ctaitem__anchor:visited{color:#0071d0}.cmp-ctaitem__icon{float:right;width:24px}.cmp-ctaitem .modal-toggle{cursor:pointer}.cmp-p-ctaitem:hover{cursor:pointer}.cmp-p-ctaitem.m--center{text-align:center}.cmp-p-ctaitem.m--resource{border:1px solid #c9c8c8;border-radius:4px;padding:24px;display:block;font-weight:400;font-size:14px}.cmp-p-ctaitem.m--resource__anchor{display:block;text-decoration:none;color:#0071d0}.cmp-p-ctaitem.m--resource .cmp-ctaitem__icon{top:0;color:#c9c8c8}.cmp-p-ctaitem.m--video .cmp-ctaitem{display:inline-block;text-align:center;margin:0;height:40px;padding:0 24px 0 24px;margin-top:8px;width:auto}.cmp-p-ctaitem.m--video .cmp-ctaitem__anchor{color:#0071d0;font-weight:400}.cmp-p-ctaitem.m--video .cmp-ctaitem .cmp-ctaitem__icon{height:32px;width:32px;margin-top:-3px;border-radius:50%;background-color:#e71316;margin-left:18px;padding-top:5px;color:#fff}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#e71316;border:solid 1px #e71316}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem:hover{background-color:#d01013;border:solid 1px #d01013;cursor:pointer}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #d01013;background-color:#e71316}.cmp-p-ctaitem.m--btn-primary .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#555759;border:solid 1px #555759}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem:hover{background-color:#222;border:solid 1px #222}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #222;background-color:#555759}.cmp-p-ctaitem.m--btn-secondary .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background-color:#fff;border:solid 1px #dcdcdc}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem__anchor{color:#0071d0;font-size:14px}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem:hover{background-color:#fff;border:solid 1px #0071d0}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-outline .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;color:#555759;background-color:#fff;border:solid 1px #dcdcdc}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem__anchor{color:#555759;font-size:14px}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem:hover{border:solid 1px #555759}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-info .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;padding:0 24px 0 24px;box-sizing:border-box;line-height:40px;color:#222;width:auto;background:0 0;border:solid 1px #fff}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__anchor{color:#fff;font-size:14px}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__anchor:hover{color:#222}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem:hover{color:#222;background-color:#fff;border:solid 1px #fff}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem:active{box-shadow:inset 0 2px 5px 2px #dcdcdc}.cmp-p-ctaitem.m--btn-white .cmp-ctaitem__icon{margin-top:8px;margin-left:8px}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem{display:inline-block;text-align:left;margin:0;border-radius:3px;font-weight:700;font-size:14px;height:40px;box-sizing:border-box;line-height:40px;width:auto;border:none;background:0 0;color:#0071d0;padding:0;align-items:center}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:hover{border:none;color:#005daa}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:hover .cmp-ctaitem__icon{color:#005daa}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:active{border:none;background:0 0;color:#262262}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem:active .cmp-ctaitem__icon{color:#262262}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem__anchor{font-size:14px}.cmp-p-ctaitem.m--btn-link .cmp-ctaitem__icon{float:left;display:inline-block;padding-top:8px;margin-right:8px;color:#0071d0}.cmp-p-ctaitem.m--mini .cmp-ctaitem{height:30px;line-height:30px;padding:0 16px 0 16px}.cmp-p-ctaitem.m--mini .cmp-ctaitem__icon{margin-top:2px}.cmp-p-ctaitem.m--small .cmp-ctaitem{height:34px;line-height:34px;padding:0 16px 0 16px}.cmp-p-ctaitem.m--small .cmp-ctaitem__icon{margin-top:5px}.cmp-p-ctaitem.m--large .cmp-ctaitem{height:50px;line-height:50px;padding:0 24px 0 24px}.cmp-p-ctaitem.m--large .cmp-ctaitem__icon{margin-top:12px}.cmp-p-ctaitem.m--block .cmp-ctaitem{width:100%}.cmp-p-ctaitem.m--left-icon .cmp-ctaitem__icon{display:inline-block;float:left;width:24px;margin-right:10px;margin-left:0}.cmp-p-ctaitem.m--lc-cta .cmp-ctaitem{width:fit-content}.cmp-p-ctaitem.m--lc-cta .cmp-ctaitem__icon{left:0;float:right;margin-right:10px;margin-left:10px}.cmp-p-ctaitem.m--lc-cta-left{margin-top:24px}.cmp-p-ctaitem.m--lc-cta-left .cmp-ctaitem__icon{float:left;margin-right:10px;margin-left:10px;transform:rotate(179deg)}@media (min-width:1200px){.cmp-p-ctaitem.m--sticky-lc{position:fixed;top:155px;max-width:245px}}.m-l1{margin:16px}.m-l2{margin:24px}.m-l3{margin:32px}.m-l4{margin:48px}.m-l5{margin:64px}.m-l0{margin:0!important}.mx-l1{margin:0 16px}.mx-l2{margin:0 24px}.mx-l3{margin:0 32px}.mx-l4{margin:0 48px}.mx-l5{margin:0 64px}.mx-l1{margin:16px 0}.mx-l2{margin:24px 0}.mx-l3{margin:32px 0}.mx-l4{margin:48px 0}.mx-l5{margin:64px 0}.mt-l1{margin-top:16px}.mt-l2{margin-top:24px}.mt-l3{margin-top:32px}.mt-l4{margin-top:48px}.mt-l5{margin-top:64px}.mb-l1{margin-bottom:16px}.mb-l2{margin-bottom:24px}.mb-l3{margin-bottom:32px}.mb-l4{margin-bottom:48px}.mb-l5{margin-bottom:64px}.ml-l1{margin-left:16px}.ml-l2{margin-left:24px}.ml-l3{margin-left:32px}.ml-l4{margin-left:48px}.ml-l5{margin-left:64px}.mr-l1{margin-right:16px}.mr-l2{margin-right:24px}.mr-l3{margin-right:32px}.mr-l4{margin-right:48px}.mr-l5{margin-right:64px}.p-l1{padding:16px}.p-l2{padding:24px}.p-l3{padding:32px}.p-l4{padding:48px}.p-l5{padding:64px}.p-l0{padding:0!important}.px-l1{padding:0 16px}.px-l2{padding:0 24px}.px-l3{padding:0 32px}.px-l4{padding:0 48px}.px-l5{padding:0 64px}.px-l1{padding:16px 0}.px-l2{padding:24px 0}.px-l3{padding:32px 0}.px-l4{padding:48px 0}.px-l5{padding:64px 0}.pt-l1{padding-top:16px}.pt-l2{padding-top:24px}.pt-l3{padding-top:32px}.pt-l4{padding-top:48px}.pt-l5{padding-top:64px}.pb-l1{padding-bottom:16px}.pb-l2{padding-bottom:24px}.pb-l3{padding-bottom:32px}.pb-l4{padding-bottom:48px}.pb-l5{padding-bottom:64px}.pl-l1{padding-left:16px}.pl-l2{padding-left:24px}.pl-l3{padding-left:32px}.pl-l4{padding-left:48px}.pl-l5{padding-left:64px}.pr-l1{padding-right:16px}.pr-l2{padding-right:24px}.pr-l3{padding-right:32px}.pr-l4{padding-right:48px}.pr-l5{padding-right:64px}.mt-s0{margin-top:0}.mt-s1{margin-top:2px}.mt-s2{margin-top:4px}.mt-s3{margin-top:8px}.mt-s4{margin-top:12px}.mt-s5{margin-top:16px}.mt-s6{margin-top:24px}.mt-s7{margin-top:32px}.mt-s8{margin-top:40px}.mt-s9{margin-top:48px}.mb-s0{margin-bottom:0}.mb-s1{margin-bottom:2px}.mb-s2{margin-bottom:4px}.mb-s3{margin-bottom:8px}.mb-s4{margin-bottom:12px}.mb-s5{margin-bottom:16px}.mb-s6{margin-bottom:24px}.mb-s7{margin-bottom:32px}.mb-s8{margin-bottom:40px}.mb-s9{margin-bottom:48px}.ml-s0{margin-left:0}.ml-s1{margin-left:2px}.ml-s2{margin-left:4px}.ml-s3{margin-left:8px}.ml-s4{margin-left:12px}.ml-s5{margin-left:16px}.ml-s6{margin-left:24px}.ml-s7{margin-left:32px}.ml-s8{margin-left:40px}.ml-s9{margin-left:48px}.mr-s0{margin-right:0}.mr-s1{margin-right:2px}.mr-s2{margin-right:4px}.mr-s3{margin-right:8px}.mr-s4{margin-right:12px}.mr-s5{margin-right:16px}.mr-s6{margin-right:24px}.mr-s7{margin-right:32px}.mr-s8{margin-right:40px}.mr-s9{margin-right:48px}.pt-s0{padding-top:0}.pt-s1{padding-top:2px}.pt-s2{padding-top:4px}.pt-s3{padding-top:8px}.pt-s4{padding-top:12px}.pt-s5{padding-top:16px}.pt-s6{padding-top:24px}.pt-s7{padding-top:32px}.pt-s8{padding-top:40px}.pt-s9{padding-top:48px}.pb-s0{padding-bottom:0}.pb-s1{padding-bottom:2px}.pb-s2{padding-bottom:4px}.pb-s3{padding-bottom:8px}.pb-s4{padding-bottom:12px}.pb-s5{padding-bottom:16px}.pb-s6{padding-bottom:24px}.pb-s7{padding-bottom:32px}.pb-s8{padding-bottom:40px}.pb-s9{padding-bottom:48px}.pl-s0{padding-left:0}.pl-s1{padding-left:2px}.pl-s2{padding-left:4px}.pl-s3{padding-left:8px}.pl-s4{padding-left:12px}.pl-s5{padding-left:16px}.pl-s6{padding-left:24px}.pl-s7{padding-left:32px}.pl-s8{padding-left:40px}.pl-s9{padding-left:48px}.pr-s0{padding-right:0}.pr-s1{padding-right:2px}.pr-s2{padding-right:4px}.pr-s3{padding-right:8px}.pr-s4{padding-right:12px}.pr-s5{padding-right:16px}.pr-s6{padding-right:24px}.pr-s7{padding-right:32px}.pr-s8{padding-right:40px}.pr-s9{padding-right:48px}.search{position:relative;padding:0;background:#f3f3f3}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.search input{text-transform:none;letter-spacing:1px;background:0 0;border:1px solid #f3f3f3;padding:0 8px;width:190px;height:28px;line-height:28px;margin:0;outline:0;color:#333;position:relative;z-index:1;color:#333}.search input.selector-input-adjust{width:190px}.search input.suggested{color:#c9c8c8}.search input::-ms-clear{display:none;width:0;height:0}.search .search-button{background:0 0;border:none;float:right;height:30px;margin:0;text-align:center;padding:0;width:40px;filter:none;outline:0!important;border-bottom:4px solid transparent}.search .search-button span{display:inline-block;vertical-align:middle;background:url(../images/white/icons-utility.png);width:22px;height:26px;background-position:-4px -267px;text-indent:-9999px}.search .search-button.active{border-color:#ee3134}.search form.active input{width:330px}.search form.active input.selector-input-adjust{width:190px}.search form .searchAutoCompleteProviderSelector{position:relative;top:1px;width:160px;height:28px;background-color:#c9c8c8;border-radius:0;border:0;outline:1px solid #d8d8d8;margin:0;float:left}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search form.providers-enabled input{width:190px}.search li,.search ul{margin:0}.clearable{display:inline-block;position:absolute;cursor:pointer;right:.85rem;top:.85rem;font-size:1.2rem;z-index:54;width:18px;height:28px}.searchRemoveHide{display:none!important}div.search{padding:0}#search-mobile-button{display:none;position:fixed;left:35px;margin-top:-32px}#header-typeahead-suggested{display:none;color:#aaa;-webkit-text-fill-color:#aaa;position:absolute;top:0;right:1px;left:0;bottom:1px;background:0 0;z-index:0;width:100%}#header-typeahead-suggested.active{display:block}.ac_results{box-shadow:0 1px 2px rgba(0,0,0,.1);background:#fff;border:1px solid #d8d8d8;padding:10px;z-index:1;right:50px!important;top:34px!important}.ac_results li{color:#555;cursor:pointer;padding:2px 5px}.ac_results li.ac_over,.ac_results li:hover{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_skip,.ac_results li.ac_skip:hover{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip em{font-style:normal}#header-typeahead{left:2px;z-index:500;overflow:hidden;width:663px;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-top:2px;margin-left:-2px;outline:0}#header-typeahead a{cursor:pointer}#header-typeahead .typeahead-terms{float:left;width:70%;position:relative;z-index:508;overflow:hidden;font-size:12px}#header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}#header-typeahead .typeahead-span strong{font-weight:400;color:gray}#header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}#header-typeahead ul{list-style:none}#header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 10px;width:100%!important}#header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .typeahead-term-list li a{display:block;width:100%!important}#header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent}#header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}#header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}#header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}#header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}#header-typeahead .title-text{color:#1e8ae7}#header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}.flyout-recent-searches,.flyout-typeahead{display:none}.flyout-recent-searches li{display:block;line-height:22px;padding:0 10px}.flyout-recent-searches li.term a{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-recent-searches li.term a.active span{border-bottom:2px solid #ee3134}.flyout-recent-searches li.term a:hover{background-color:#ebf2fa}.flyout-recent-searches li.recent-searches{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#f9f9f9;font-weight:700}.flyout-recent-searches li.recent-searches em{font-style:normal}.flyout-search-shortcut .search-shortcut-list{border-top:1px solid #d8d8d8}.flyout-search-shortcut .search-shortcut-list li{display:block;line-height:22px;padding:0 10px}.flyout-search-shortcut .search-shortcut-list li.quickLinks a{display:inline-block;color:#1e8ae7;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-search-shortcut_right{width:30%;float:right}.searchAutoCompleteProviderSelectorIE78{padding-top:4px;padding-bottom:3px;width:180px;height:30px;position:absolute;left:4px;top:4px;border:1px solid #d8d8d8;background-color:#e5e5e5;z-index:2}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.msie78Search{width:190px}.ie8 .header_row_1.layout_cont_middle{clear:both!important}.ie8 .header_row_2.layout_cont_middle{margin-left:285px!important}.ie8 #meganav-content{display:block!important}.ie8 .hide-meganav #meganav-content{display:none!important}@media (max-width:979px){.typeahead-group{padding:5px 30px!important}.general_search.layout_cont_middle{margin-right:0}.header_row_2.layout_cont_left{width:95%;float:none;margin:auto}.header_row_2.layout_cont_middle{width:95%;margin:auto}.header_row_2.layout_cont_left,.header_row_2.layout_cont_middle{padding:0 15px 0 15px!important}.layout_cont_right{float:none;width:100%}#mobile-search-button-container{float:right;width:50px;height:60px;border-left:1px solid #eee;border-right:1px solid #eee}#search-mobile-button{display:block;height:60px;width:50px;border:none;background:0 0;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-search-black.svg);background-repeat:no-repeat;background-position:center;position:relative;left:0;margin-top:0}#search-mobile-button.active{border-bottom:3px solid #ee3134;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-cross-black.svg);background-repeat:no-repeat;background-size:18px 18px}#focusAreaSelector{width:100%!important;margin:auto}.container-modifier{padding:0!important}#search-main.in{display:block;overflow:auto;overflow-x:hidden;overflow-y:auto;position:fixed;z-index:200;bottom:0;top:61px;left:0;right:0;background:#fff}#search-main.in .searchHeading{display:block!important;padding:40px 0 24px 0;font-size:25.35px;color:#a2a2a2;text-align:center;font-weight:400}#search-main.in .searchHeading span{color:#333;font-weight:700}.global-commerce-bar .logo img{height:28px}.search form{background:#fff;height:auto;border:none!important;margin-top:0;margin:auto;width:100%}.search form input{box-sizing:border-box;line-height:40px;height:60px;width:100%!important;-webkit-appearance:none;-moz-appearance:none;appearance:none;border:1px solid #dcdcdc}.search form input.active input{height:60px!important}.search form input.selector-input-adjust{width:100%}.search form .search-button{display:none;position:absolute;top:273px;width:100%!important;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:3px 3px!important;margin:auto;left:0;right:0}.search form .search-button img{display:none}.search form .search-button .search-text{display:inline-block}.search form .searchAutoCompleteProviderSelector{top:0;width:100%!important;line-height:40px;height:40px;float:none}#header-typeahead-input-container{width:100%;height:60px;left:0;right:0;margin:auto;padding:16px 0 16px 0;background:#fff}#header-typeahead{width:100%;top:77px;margin:auto;left:0;right:0}}@media only screen and (max-device-width:320px){.global-commerce-bar{height:60px;position:fixed;top:0;left:0;width:100%;margin:0;background:#fff;z-index:80;font-size:14px;border-bottom:1px solid #eee}.global-commerce-bar .logo{margin:0 0 0 54px!important;text-align:left;padding:15px 0 15px 0}.global-commerce-bar .user-utility{padding:0;margin:0}#header-nav-container #header-nav-button{width:50px;padding-left:15px}.search form{height:60px}.search form .search-button{display:block;position:absolute;top:229px;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:4px;margin:auto}.search form .search-button img{display:none}.search form .search-button .search-text{display:inline-block}.search form .searchAutoCompleteProviderSelector{height:60px}#mobile-search-button-container,#search-mobile-button{width:40px}#search-main.in{min-height:568px}#search-main.in .searchHeading{padding:16px 0 13px 0}#search-main.in .searchHeading p{font-size:16.25px}}@media (max-width:767px){.search-button{display:none}.clearable{top:2.25rem;right:2.85rem}.typeahead-group{padding:5px 10px!important}}@media (max-width:979px){.search form.active input{height:60px!important}.clearable{top:2.25rem!important;right:2.85rem!important}}.search{padding:0;background:0 0}.search .largeSearchBar .loading-wheel-sm{margin:16px 16px}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.search input{height:50px;width:100%;box-sizing:border-box;background:0 0;letter-spacing:0;font-size:13px;padding-left:22px;border:none;border-top:1px solid #d8d8d8;border-bottom:1px solid #d8d8d8;line-height:28px;margin:0;outline:0;position:relative;z-index:1;color:#000}.search input.selector-input-adjust{width:100%}.search input::-ms-clear{display:none}.search input:-moz-placeholder,.search input:-ms-input-placeholder,.search input::-moz-placeholder,.search input::-webkit-input-placeholder,.search input::placeholder{color:#a2a2a2}.search .search-button span{display:inline-block;vertical-align:middle}.search .search-button.active{border-color:#ee3134}.search form{margin:0}.search form .search-button{border-radius:0 3px 3px 0!important;margin:0;text-align:center;filter:none;outline:0!important;border:none;height:50px;width:100px;background:#4a4a4a}.search form .search-button .search-text{display:none}.search form.active input{height:100%}.search form.active input.selector-input-adjust{width:100%}.search form .searchAutoCompleteProviderSelector{position:relative;width:285px;height:50px;background-color:#f9f9f9;border:0;margin:0;line-height:normal}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search li,.search ul{margin:0}.clearable{background:transparent url(/search/searchbar/resources/images/icon_16_close_mono@1_5x.svg) no-repeat right -20px center}.clearable.x{background-position:right 20px center}.clearable.onX{cursor:pointer}.clearable::-ms-clear{display:none;width:0;height:0}div.search{padding:0}#header-typeahead-input-container{width:100%;height:50px}#header-typeahead{width:100%;z-index:500;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-top:0;outline:0}#header-typeahead a{cursor:pointer}#header-typeahead .typeahead-terms{float:left;width:70%;position:relative;z-index:508;overflow-y:auto;overflow-x:hidden;max-height:510px;font-size:12px}#header-typeahead .typeahead-term-list li a.typeahead-term{font-weight:500}.searchAutoCompleteProviderSelectorIE78{width:203px;height:52px;background-color:#f9f9f9;border:solid 0 #cdcccc;position:relative;top:0;outline:1px solid #d8d8d8;margin:0;float:left;padding-top:4px;line-height:normal;z-index:2}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.search-btn-icon{width:28px;height:28px}.chosen-container{position:relative;display:inline-block;vertical-align:middle;font-size:14px;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.chosen-container *{-webkit-box-sizing:border-box;box-sizing:border-box}.chosen-container .chosen-drop{position:absolute;top:100%;z-index:1010;width:100%;border:1px solid #aaa;border-top:0;background:#fff;-webkit-box-shadow:0 4px 5px rgba(0,0,0,.15);box-shadow:0 4px 5px rgba(0,0,0,.15);clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container a{cursor:pointer}.chosen-container .chosen-single .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .chosen-single .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .search-choice .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .search-choice .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-results{color:#444;position:relative;overflow-x:hidden;overflow-y:auto;margin:0 4px 4px 0;padding:0 0 0 4px;max-height:350px;-webkit-overflow-scrolling:touch}.chosen-container .chosen-results li{display:none;margin:0;padding:5px 6px;list-style:none;line-height:15px;word-wrap:break-word;-webkit-touch-callout:none}.chosen-container .chosen-results li em{font-style:normal;text-decoration:underline}.chosen-container .chosen-results li.active-result{display:list-item;cursor:pointer}.chosen-container .chosen-results li.disabled-result{display:list-item;color:#ccc;cursor:default}.chosen-container .chosen-results li.highlighted{background-color:#3875d7;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#3875d7),color-stop(90%,#2a62bc));background-image:linear-gradient(#3875d7 20%,#2a62bc 90%);color:#fff}.chosen-container .chosen-results li.no-results{color:#777;display:list-item;background:#f4f4f4}.chosen-container .chosen-results li.group-result{display:list-item;font-weight:700;cursor:default}.chosen-container .chosen-results li.group-option{padding-left:15px}.chosen-container.chosen-with-drop .chosen-drop{clip:auto;-webkit-clip-path:none;clip-path:none}.chosen-container-single .chosen-single{position:relative;display:block;overflow:hidden;padding:0 0 0 8px;height:25px;border:1px solid #aaa;border-radius:5px;background-color:#fff;background:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#fff),color-stop(50%,#f6f6f6),color-stop(52%,#eee),to(#f4f4f4));background:linear-gradient(#fff 20%,#f6f6f6 50%,#eee 52%,#f4f4f4 100%);background-clip:padding-box;-webkit-box-shadow:0 0 3px #fff inset,0 1px 1px rgba(0,0,0,.1);box-shadow:0 0 3px #fff inset,0 1px 1px rgba(0,0,0,.1);color:#444;text-decoration:none;white-space:nowrap;line-height:24px}.chosen-container-single .chosen-single span{display:block;overflow:hidden;margin-right:26px;text-overflow:ellipsis;white-space:nowrap}.chosen-container-single .chosen-single abbr{position:absolute;top:6px;right:26px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-single .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single .chosen-single div{position:absolute;top:0;right:0;display:block;width:18px;height:100%}.chosen-container-single .chosen-single div b{display:block;width:100%;height:100%;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 0 2px}.chosen-container-single .chosen-default{color:#999}.chosen-container-single .chosen-single-with-deselect span{margin-right:38px}.chosen-container-single .chosen-search{position:relative;z-index:1010;margin:0;padding:3px 4px;white-space:nowrap}.chosen-container-single .chosen-search input[type=text]{margin:1px 0;padding:4px 20px 4px 5px;width:100%;height:auto;outline:0;border:1px solid #aaa;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 100% -20px;font-size:1em;font-family:sans-serif;line-height:normal;border-radius:0}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single.chosen-container-single-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container-multi .chosen-choices{position:relative;overflow:hidden;margin:0;padding:0 5px;width:100%;height:auto;border:1px solid #aaa;background-color:#fff;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(1%,#eee),color-stop(15%,#fff));background-image:linear-gradient(#eee 1%,#fff 15%);cursor:text}.chosen-container-multi .chosen-choices li{float:left;list-style:none}.chosen-container-multi .chosen-choices li.search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi .chosen-choices li.search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi .chosen-choices li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi .chosen-choices li.search-choice span{word-wrap:break-word}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi .chosen-choices li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi .chosen-choices li.search-choice-focus{background:#d4d4d4}.chosen-container-multi .chosen-choices li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-multi .chosen-drop .result-selected{display:list-item;color:#ccc;cursor:default}.chosen-container-active .chosen-single{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#eee),color-stop(80%,#fff));background-image:linear-gradient(#eee 20%,#fff 80%);-webkit-box-shadow:0 1px 0 #fff inset;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-disabled{opacity:.5!important;cursor:default}.chosen-disabled .chosen-single{cursor:default}.chosen-disabled .chosen-choices .search-choice .search-choice-close{cursor:default}.chosen-rtl{text-align:right}.chosen-rtl .chosen-single{overflow:visible;padding:0 8px 0 0}.chosen-rtl .chosen-single span{margin-right:0;margin-left:26px;direction:rtl}.chosen-rtl .chosen-single div{right:auto;left:3px}.chosen-rtl .chosen-single abbr{right:auto;left:26px}.chosen-rtl .chosen-single-with-deselect span{margin-left:38px}.chosen-rtl .chosen-choices li{float:right}.chosen-rtl .chosen-choices li.search-field input[type=text]{direction:rtl}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-choice .search-choice-close{right:auto;left:4px}.chosen-rtl .chosen-results li.group-option{padding-right:15px;padding-left:0}.chosen-rtl .chosen-search input[type=text]{padding:4px 5px 4px 20px;background:url(/search/searchbar/resources/resources/images/chosen-sprite.png) no-repeat -30px -20px;direction:rtl}.chosen-rtl.chosen-container-single .chosen-results{margin:0 0 4px 4px;padding:0 4px 0 0}.chosen-rtl.chosen-container-single .chosen-single div b{background-position:6px 2px}.chosen-rtl.chosen-container-active.chosen-with-drop .chosen-single div{border-right:none}.chosen-rtl.chosen-container-single.chosen-with-drop .chosen-single div b{background-position:-12px 2px}@media only screen and (-webkit-min-device-pixel-ratio:1.5){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:144dpi){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:1.5dppx){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}.chosen-container-single .chosen-single{height:50px!important;border-radius:0!important;border-radius:3px 0 0 3px!important;background-color:#f9f9f9!important;border:1px solid #d8d8d8!important;outline:0!important;background-image:none!important;padding:0 20px 0 16px;box-shadow:none!important}.chosen-container-single .chosen-single>span{line-height:50px}.chosen-container-single .chosen-single div{right:20px}.chosen-container-single .chosen-single div b{background:0 0!important;border-color:#222 transparent transparent transparent;border-style:solid;border-width:5px 4px 0 4px;height:0!important;left:50%;margin-left:-4px;margin-top:-2px;position:absolute;top:50%;width:0!important}.chosen-drop{border-top:1px solid #d8d8d8}.chosen-drop .chosen-results{margin:0!important;padding:0!important;border-top:1px solid #dcdcdc}.chosen-drop .chosen-results .active-result.result-selected,.chosen-drop .chosen-results .active-result.result-selected.highlighted{background-repeat:no-repeat;background-size:10% 100%;background-position:left;color:#fff!important;background-color:#007fff!important;background-image:none!important}.chosen-drop .chosen-results .group-result{border-top:1px solid #dcdcdc;color:#a2a2a2}.chosen-drop .chosen-results li.group-option{padding-left:1.5rem;color:#000;padding-top:5px;padding-bottom:5px;font-size:13px}.chosen-drop .chosen-results li.group-option.highlighted{color:#000!important;background:#ebf2fa!important}.chosen-drop .chosen-results .active-result.highlighted{color:#000!important;background:#ebf2fa!important}@media screen and (max-width:767px){.flyout-typeahead .typeahead-terms{width:100%}.flyout-typeahead .flyout-search-shortcut_right{width:100%;display:flex}.flyout-typeahead .flyout-search-shortcut_right ul{width:100%}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}}@media (min-width:768px) and (max-width:991px){#header-typeahead{height:calc(100vh - 412px)!important}.flyout-typeahead .typeahead-terms{width:70%!important;float:left!important;border-right:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right{width:30%;float:right;border-left:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}.flyout-typeahead .typeahead-terms .typeahead-term-list{border-bottom:unset!important}}@media (min-width:992px) and (max-width:1023px){.flyout-typeahead .typeahead-terms{width:100%}.flyout-typeahead .flyout-search-shortcut_right{width:100%;display:flex}.flyout-typeahead .flyout-search-shortcut_right ul{width:100%}#header-typeahead .search-shortcut-list{border:unset!important}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}}@media (min-width:1024px) and (max-width:2560px){.flyout-typeahead .typeahead-terms{width:70%!important;float:left!important;border-right:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right{width:30%;float:right;border-left:1px solid #e5e5e5}.flyout-typeahead .flyout-search-shortcut_right ul .search-suggestions{font-size:100%;font-weight:500!important}.flyout-typeahead .typeahead-terms .typeahead-term-list{border-bottom:unset!important}}.layout_cont_middle #autoComplete_list_1{padding-inline-start:0}.layout_cont_middle #autoComplete_list_1 li{list-style:none;cursor:default}.layout_cont_middle .typeahead-term-list-ul{width:100%;z-index:500;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);margin-top:0;outline:0;font-size:12px}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space{line-height:22px;padding:5px 20px!important;width:70%}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space:hover{background:#ebf2fa!important}.layout_cont_middle .typeahead-term-list-ul a.typeahead-term{display:inline-block;color:#333!important;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500;text-decoration:none!important;width:100%!important;cursor:pointer}.layout_cont_middle .typeahead-term-list-ul a.typeahead-term .typeahead-span mark{font-weight:400;color:gray;background-color:unset}.layout_cont_middle .typeahead-term-list-ul .product-title{font-family:HelveticaNeue,Helvetica,Arial,sans-serif;line-height:22px;padding:5px 20px!important;font-weight:500;cursor:default;background-color:#f7f7f7;font-size:12px;pointer-events:none;color:#1b1b1d;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .result-item-label{width:70%;font-family:HelveticaNeue,Helvetica,Arial,sans-serif}.layout_cont_middle .typeahead-term-list-ul .result-item-label a{padding:5px 20px!important;font-size:12px;font-weight:400}.layout_cont_middle .typeahead-term-list-ul .result-item-label a:hover{background:#ebf2fa!important;width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list{border-top:1px solid #dcdcdc;cursor:pointer;font-size:14px;width:70%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list div{line-height:22px}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list a.quickLinks{display:block;color:#0071d0;padding:10px 20px 6px;width:100%;cursor:pointer;text-decoration:none;font-weight:500}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list .search-shortcuts-list-header{font-size:14px;line-height:18px;font-family:HelveticaNeue,Helvetica,Arial,sans-serif;padding:5px 20px;cursor:default;font-weight:500;line-height:22px;background:#f7f7f7;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data{border-top:1px solid #dcdcdc;cursor:pointer;font-size:14px;width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data div{line-height:22px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data a.quickLinks{display:block;color:#0071d0;padding:10px 20px 6px;width:100%;cursor:pointer;text-decoration:none;font-weight:500}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term{padding:5px 20px}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term:hover{background-color:#ebf2fa}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .recent-search-term a:hover{border-bottom:2px solid #ee3134}.layout_cont_middle .typeahead-term-list-ul .search-shortcut-list-no-data .search-shortcuts-list-header{font-size:14px;line-height:18px;font-family:HelveticaNeue,Helvetica,Arial,sans-serif;padding:5px 20px;cursor:default;font-weight:500;line-height:22px;background:#f7f7f7;margin-bottom:5px}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{position:absolute;min-width:30%;width:fit-content;left:70%;height:100%;background:inherit;border:inherit;border-left:1px solid #e5e5e5;box-sizing:content-box;white-space:nowrap}.layout_cont_middle .search-suggestions{margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5;font-size:12px}.layout_cont_middle .recent-search-shortcuts-list a.quickLinks{display:block;color:#1e8ae7;padding:10px 0 6px;width:100%;cursor:pointer;text-decoration:none}.layout_cont_middle #searchMagnifyMobile{z-index:1!important;position:absolute!important;right:0!important;top:0!important}.layout_cont_middle #generalSearchInput #clearable{height:22px!important;width:16px!important}.layout_cont_middle [hidden]{display:none!important}@media screen and (max-width:767px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;overflow-y:scroll}.layout_cont_middle .typeahead-term-list-ul{width:100%}.layout_cont_middle .typeahead-term-list-ul .typeahead-list-space{width:100%}.layout_cont_middle .typeahead-term-list-ul .result-item-label{width:100%}.layout_cont_middle .typeahead-term-list-ul .search-shortcuts-list{width:100%}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{width:100%;left:0;border-top:1px solid #e5e5e5}}@media (min-width:768px) and (max-width:991px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;display:flex;flex-direction:column}}@media (min-width:992px) and (max-width:1023px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0}.layout_cont_middle .typeahead-term-list-ul .typeahead__container__shortcuts_right{width:100%;left:0;border-top:1px solid #e5e5e5}}@media (min-width:1024px) and (max-width:2560px){.layout_cont_middle #autoComplete_list_1{padding-inline-start:0;display:flex;flex-direction:column;min-height:143px}}header .search-container .close{position:absolute;right:36px;width:42px;height:42px;opacity:1;z-index:1001}header .search-container.open{position:inherit}header .search-container.open .close{display:inline-block}header input::-webkit-input-placeholder{font-weight:400;font-size:12px;color:#a2a2a2;text-overflow:ellipsis}#focusAreaSelector{width:auto}.search li,.search ul{margin:0}.search input{font-size:14px;box-shadow:none;height:50px;width:100%;box-sizing:border-box;background:0 0;border-top:1px solid #d8d8d8;border-bottom:1px solid #d8d8d8;border-left:1px solid #f3f3f3;border-right:1px solid #f3f3f3;line-height:28px;margin:0;outline:0;position:relative;z-index:1;text-transform:none;padding:0 48px 0 22px;color:#333}.search input::-ms-clear{display:none;width:0;height:0}.search input:-moz-placeholder,.search input:-ms-input-placeholder,.search input::-moz-placeholder,.search input::-webkit-input-placeholder,.search input::input-placeholder,.search input::placeholder{font-weight:400;font-size:14px;line-height:22px;color:#a2a2a2;text-overflow:ellipsis}.search input .selector-input-adjust{width:100%}.search input.suggested{color:#c9c8c8}.search .search-btn-icon{height:32px;width:32px;margin-top:4px}.search form{margin:0;position:relative;display:inherit}.search form input{height:50px}.search form.active input{height:50px}.search form.active input.selector-input-adjust{width:100%}.search form .searchAutoCompleteProviderSelector{position:relative;width:285px;height:50px;background-color:#f9f9f9;border:0;margin:0;line-height:normal;top:1px;border-radius:0;outline:1px solid #d8d8d8;float:left}.search form .searchAutoCompleteProviderSelector optgroup,.search form .searchAutoCompleteProviderSelector option{background-color:#e5e5e5}.search form .searchAutoCompleteProviderSelector:focus optgroup,.search form .searchAutoCompleteProviderSelector:focus option{background-color:#fff}.search form.providers-enabled input{width:100%}.search button,.search input{font-size:14px;margin-bottom:0;box-shadow:none}.global-commerce-bar{height:60px;position:fixed;top:0;left:0;width:100%;margin:0;background:#fff;z-index:80;font-size:14px;border-bottom:1px solid #eee}.global-commerce-bar .logo{margin:0 0 0 54px!important;text-align:left;padding:15px 0 15px 0}.global-commerce-bar .user-utility{padding:0;margin:0}.global-commerce-bar-spacing{height:0;border-bottom:none}#header-nav-container #header-nav-button{width:50px;padding-left:15px}#search-mobile-button{display:none;position:fixed;width:40px;left:35px;margin-top:-32px}#search-mobile-button-container{width:40px}#search-main.in{min-height:568px}#search-main.in .searchHeading{padding:16px 0 13px 0}#search-main.in .searchHeading p{font-size:16.25px}.clearable{position:absolute;cursor:pointer;top:32px;right:58px;width:16px;z-index:1}.clearable::-ms-clear{display:none;width:0;height:0}.clearable.x{background-position:right 20px center}.clearable.onX{cursor:pointer}.typeahead-group{padding:5px 10px!important}.chosen-container{position:relative;display:inline-block;vertical-align:middle;font-size:14px;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.chosen-container *{-webkit-box-sizing:border-box;box-sizing:border-box}.chosen-container .chosen-drop{position:absolute;top:100%;z-index:1010;width:100%;border:1px solid #aaa;border-top:0;background:#fff;-webkit-box-shadow:0 4px 5px rgba(0,0,0,.15);box-shadow:0 4px 5px rgba(0,0,0,.15);clip:rect(0,0,0,0);clip-path:inset(100% 100%);border-top:0}.chosen-container .chosen-with-drop .chosen-drop{clip:auto;clip-path:none}.chosen-container a{cursor:pointer}.chosen-container .chosen-single .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .chosen-single .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container .chosen-single.chosen-disabled-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);clip-path:inset(100% 100%)}.chosen-container .search-choice .group-name{margin-right:4px;overflow:hidden;white-space:nowrap;text-overflow:ellipsis;font-weight:400;color:#999}.chosen-container .search-choice .group-name:after{content:":";padding-left:2px;vertical-align:top}.chosen-container .chosen-results{color:#444;position:relative;overflow-x:hidden;overflow-y:auto;margin:0 4px 4px 0;padding:0 0 0 4px;max-height:350px;-webkit-overflow-scrolling:touch}.chosen-container .chosen-results li{display:none;margin:0;padding:5px 6px;list-style:none;line-height:15px;word-wrap:break-word;-webkit-touch-callout:none}.chosen-container .chosen-results li em{font-style:normal;text-decoration:underline}.chosen-container .chosen-results li.active-result{display:list-item;cursor:pointer}.chosen-container .chosen-results li.disabled-result{display:list-item;color:#ccc;cursor:pointer}.chosen-container .chosen-results li.highlighted{background-color:#3875d7;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#3875d7),color-stop(90%,#2a62bc));background-image:linear-gradient(#3875d7 20%,#2a62bc 90%);color:#fff}.chosen-container .chosen-results li.no-results{color:#777;display:list-item;background:#f4f4f4}.chosen-container .chosen-results li.group-result{display:list-item;font-weight:700;cursor:default}.chosen-container .chosen-results li.group-option{padding-left:15px}.chosen-container.chosen-with-drop .chosen-drop{clip:auto;-webkit-clip-path:none;clip-path:none}.chosen-container-single .chosen-single{position:relative;display:block;overflow:hidden;text-decoration:none;white-space:nowrap;line-height:24px;height:50px;border-radius:3px 0 0 3px;background-color:#f9f9f9;border:1px solid #d8d8d8;outline:0;padding:0 20px 0 16px;box-shadow:none}.chosen-container-single .chosen-single span{display:block;overflow:hidden;margin-right:26px;text-overflow:ellipsis;white-space:nowrap}.chosen-container-single .chosen-single abbr{position:absolute;top:6px;right:26px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-single .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single .chosen-single div{position:absolute;top:0;right:0;display:block;width:18px;height:100%;right:20px}.chosen-container-single .chosen-single div b{display:block;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 0 2px;background:0 0!important;border-color:#222 transparent transparent transparent;border-style:solid;border-width:5px 4px 0 4px;height:0;left:50%;margin-left:-4px;margin-top:-2px;position:absolute;top:50%;width:0;background:0 0!important}.chosen-container-single .chosen-single>span{line-height:50px}.chosen-container-single .chosen-single-with-deselect span{margin-right:38px}.chosen-container-single .chosen-default{color:#999}.chosen-container-single .chosen-search{position:relative;z-index:1010;margin:0;padding:3px 4px;white-space:nowrap}.chosen-container-single .chosen-search input[type=text]{margin:1px 0;padding:4px 20px 4px 5px;width:100%;height:auto;outline:0;border:1px solid #aaa;background:url(/search/searchbar/resources/images/chosen-sprite.png) no-repeat 100% -20px;font-size:1em;font-family:sans-serif;line-height:normal;border-radius:0}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single .chosen-drop{margin-top:-1px;border-radius:0 0 4px 4px;background-clip:padding-box}.chosen-container-single.chosen-disabled .chosen-single abbr:hover{background-position:-42px -10px}.chosen-container-single.chosen-container-single-nosearch .chosen-search{position:absolute;clip:rect(0,0,0,0);-webkit-clip-path:inset(100% 100%);clip-path:inset(100% 100%)}.chosen-container-multi .chosen-choices{position:relative;overflow:hidden;margin:0;padding:0 5px;width:100%;height:auto;border:1px solid #aaa;background-color:#fff;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(1%,#eee),color-stop(15%,#fff));background-image:linear-gradient(#eee 1%,#fff 15%);cursor:text}.chosen-container-multi .chosen-choices li{float:left;list-style:none}.chosen-container-multi .chosen-choices li.search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi .chosen-choices li.search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi .chosen-choices li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi .chosen-choices li.search-choice span{word-wrap:break-word}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi .chosen-choices li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi .chosen-choices li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi .chosen-choices li.search-choice-focus{background:#d4d4d4}.chosen-container-multi .chosen-choices li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-multi .chosen-drop .result-selected{display:list-item;color:#ccc;cursor:default}.chosen-container-multi li .search-field{margin:0;padding:0;white-space:nowrap}.chosen-container-multi li .search-field input[type=text]{margin:1px 0;padding:0;height:25px;outline:0;border:0!important;background:0 0!important;-webkit-box-shadow:none;box-shadow:none;color:#999;font-size:100%;font-family:sans-serif;line-height:normal;border-radius:0;width:25px}.chosen-container-multi li.search-choice{position:relative;margin:3px 5px 3px 0;padding:3px 20px 3px 5px;border:1px solid #aaa;max-width:100%;border-radius:3px;background-color:#eee;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);background-size:100% 19px;background-repeat:repeat-x;background-clip:padding-box;-webkit-box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);box-shadow:0 0 2px #fff inset,0 1px 0 rgba(0,0,0,.05);color:#333;line-height:13px;cursor:default}.chosen-container-multi li.search-choice span{word-wrap:break-word}.chosen-container-multi li.search-choice .search-choice-close{position:absolute;top:4px;right:3px;display:block;width:12px;height:12px;background:url(/search/searchbar/resources/images/chosen-sprite.png) -42px 1px no-repeat;font-size:1px}.chosen-container-multi li.search-choice .search-choice-close:hover{background-position:-42px -10px}.chosen-container-multi li.search-choice-disabled{padding-right:5px;border:1px solid #ccc;background-color:#e4e4e4;background-image:-webkit-gradient(linear,left top,left bottom,color-stop(20%,#f4f4f4),color-stop(50%,#f0f0f0),color-stop(52%,#e8e8e8),to(#eee));background-image:linear-gradient(#f4f4f4 20%,#f0f0f0 50%,#e8e8e8 52%,#eee 100%);color:#666}.chosen-container-multi li.search-choice-focus{background:#d4d4d4}.chosen-container-multi li.search-choice-focus .search-choice-close{background-position:-42px -10px}.chosen-container-multi .chosen-results{margin:0;padding:0}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active .chosen-choices{border:1px solid #5897fb;-webkit-box-shadow:0 0 5px rgba(0,0,0,.3);box-shadow:0 0 5px rgba(0,0,0,.3)}.chosen-container-active .chosen-choices li.search-field input[type=text]{color:#222!important}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-container-active.chosen-with-drop .chosen-single{border:1px solid #aaa;border-bottom-right-radius:0;border-bottom-left-radius:0;box-shadow:0 1px 0 #fff inset}.chosen-container-active.chosen-with-drop .chosen-single div{border-left:none;background:0 0}.chosen-container-active.chosen-with-drop .chosen-single div b{background-position:-18px 2px}.chosen-disabled{opacity:.5!important;cursor:default}.chosen-disabled .chosen-single{cursor:default}.chosen-disabled .chosen-choices .search-choice .search-choice-close{cursor:default}.chosen-rtl{text-align:right}.chosen-rtl .chosen-single{overflow:visible;padding:0 8px 0 0}.chosen-rtl .chosen-single span{margin-right:0;margin-left:26px;direction:rtl}.chosen-rtl .chosen-single div{right:auto;left:3px}.chosen-rtl .chosen-single abbr{right:auto;left:26px}.chosen-rtl .chosen-single-with-deselect span{margin-left:38px}.chosen-rtl .chosen-choices li{float:right}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-field input[type=text]{direction:rtl}.chosen-rtl .chosen-choices li.search-choice{margin:3px 5px 3px 0;padding:3px 5px 3px 19px}.chosen-rtl .chosen-choices li.search-choice .search-choice-close{right:auto;left:4px}.chosen-rtl .chosen-results li.group-option{padding-right:15px;padding-left:0}.chosen-rtl .chosen-search input[type=text]{padding:4px 5px 4px 20px;background:url(/search/searchbar/resources/resources/images/chosen-sprite.png) no-repeat -30px -20px;direction:rtl}.chosen-rtl.chosen-container-single .chosen-results{margin:0 0 4px 4px;padding:0 4px 0 0}.chosen-rtl.chosen-container-single .chosen-single div b{background-position:6px 2px}.chosen-rtl.chosen-container-active.chosen-with-drop .chosen-single div{border-right:none}.chosen-rtl.chosen-container-single.chosen-with-drop .chosen-single div b{background-position:-12px 2px}.chosen-drop{border-top:1px solid #d8d8d8}.chosen-drop .chosen-results{margin:0!important;padding:0!important;border-top:1px solid #dcdcdc}.chosen-drop .chosen-results .active-result.result-selected,.chosen-drop .chosen-results .active-result.result-selected.highlighted{background-repeat:no-repeat;background-size:10% 100%;background-position:left;color:#fff!important;background-color:#007fff!important;background-image:none!important}.chosen-drop .chosen-results .group-result{border-top:1px solid #dcdcdc;color:#a2a2a2}.chosen-drop .chosen-results li.group-option{padding-left:1.5rem;color:#000;padding-top:5px;padding-bottom:5px;font-size:13px}.chosen-drop .chosen-results li.group-option.highlighted{color:#000!important;background:#ebf2fa!important}.chosen-drop .chosen-results .active-result.highlighted{color:#000!important;background:#ebf2fa!important}.searchRemoveHide{display:none!important}.typeahead-span{margin-left:0!important}.typeahead-term-list{border-bottom:1px solid #dcdcdc}.header-typeahead{left:2px;z-index:500;overflow:hidden;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;margin-left:-2px;outline:0;width:100%;background:#fff;margin-top:0}.header-typeahead a{cursor:pointer}.header-typeahead .typeahead-terms{float:left;position:relative;z-index:508;overflow:hidden;font-size:12px;width:100%;overflow-y:auto;max-height:510px}.header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}.header-typeahead .typeahead-span{margin-left:0}.header-typeahead .typeahead-span strong{font-weight:400;color:gray}.header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}.header-typeahead ul{list-style:none}.header-typeahead .typeahead-term-list{border-bottom:1px solid #dcdcdc}.header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 20px;width:100%!important}.header-typeahead .typeahead-term-list li a{display:block;width:100%!important}.header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500}.header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}.header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}.header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}.header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}.header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}.header-typeahead .title-text{color:#0071d0}.header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}#header-typeahead{overflow-x:hidden;z-index:500;overflow-y:scroll;width:100%;background:#fff;position:absolute;box-shadow:0 2px 2px rgba(0,0,0,.1);display:none;outline:0;max-height:calc(100vh - 120px)}#header-typeahead a{cursor:pointer}#header-typeahead ul{list-style:none;padding-inline-start:0}#header-typeahead span.typeahead-hr{display:block;border-bottom:1px solid #d8d8d8;margin-top:10px;margin-bottom:10px}#header-typeahead .title-text{color:#0071d0}#header-typeahead .search-shortcut-list li a.quickLinks,#header-typeahead .typeahead-term-list li a.typeahead-term{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;vertical-align:middle;border-bottom:2px solid transparent;font-weight:500}#header-typeahead .search-suggestions{padding:10px;margin-bottom:5px;font-weight:700;cursor:default;background-color:#e5e5e5}#header-typeahead .search-shortcut-list{border-top:1px solid #dcdcdc}#header-typeahead .search-shortcut-list li{display:block;line-height:22px;width:100%!important}#header-typeahead .search-shortcut-list li.highlighted{background:#ebf2fa!important}#header-typeahead .search-shortcut-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .search-shortcut-list li a{display:block;width:100%!important}#header-typeahead .search-shortcut-list li a.quickLinks{color:#0071d0;padding:10px 20px 6px}#header-typeahead .typeahead-terms{float:left;width:200px;position:relative;z-index:508;overflow:hidden;font-size:12px}#header-typeahead .typeahead-group{background:#f7f7f7;border-radius:2px;padding:5px 20px!important}#header-typeahead .typeahead-span strong{font-weight:400;color:gray}#header-typeahead .typeahead-flyout{float:left;width:442px;height:300px;background:#f8f8f8;border-left:1px solid #d8d8d8;padding:10px;position:relative;left:-1px;z-index:501;overflow:hidden}#header-typeahead .typeahead-term-list li{display:block;line-height:22px;padding:5px 20px;width:100%!important}#header-typeahead .typeahead-term-list li.highlighted{background:#ebf2fa!important}#header-typeahead .typeahead-term-list li.typeahead-ignore{padding:0;margin:0}#header-typeahead .typeahead-term-list li a{display:block;width:100%!important}#header-typeahead .typeahead-term-list li a.quickLinks{color:#0071d0}#header-typeahead .typeahead-term-list a.typeahead-term.active span{border-bottom:0}#header-typeahead .typeahead-term-list a.typeahead-term.active span .title-text{border-bottom:0}#header-typeahead-suggested{display:none;color:#aaa;-webkit-text-fill-color:#aaa;position:absolute;top:0;right:1px;left:0;bottom:1px;background:0 0;z-index:0;width:100%}#header-typeahead-suggested.active{display:block}#header-typeahead-input-container{width:100%;height:50px}.ac_results{box-shadow:0 1px 2px rgba(0,0,0,.1);background:#fff;border:1px solid #d8d8d8;padding:10px;z-index:1;right:50px!important;top:34px!important}.ac_results li{color:#555;cursor:pointer;padding:2px 5px}.ac_results li:hover{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_over{background:#f8f8f8;color:#007ed5;cursor:pointer;text-decoration:none}.ac_results li.ac_skip{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip:hover{background:#fff;border-bottom:1px solid #d8d8d8;color:#1a2155;cursor:text;display:block;font-weight:700;padding:0 5px 5px 5px;margin-bottom:5px;text-decoration:none}.ac_results li.ac_skip em{font-style:normal}.flyout-recent-searches{display:none}.flyout-recent-searches li{display:block;line-height:22px;padding:0 20px}.flyout-recent-searches li.term a{display:inline-block;color:#333;text-overflow:ellipsis;overflow:hidden;white-space:nowrap;border-bottom:2px solid transparent;width:100%!important}.flyout-recent-searches li.term a:hover{background-color:#ebf2fa}.flyout-recent-searches li.recent-searches{padding:20px;margin-bottom:5px;cursor:default;background-color:#f9f9f9;font-weight:700}.flyout-recent-searches li.recent-searches em{font-style:normal}.flyout-typeahead{display:none}.searchAutoCompleteProviderSelectorIE78{width:203px;height:52px;background-color:#f9f9f9;border:solid 0 #cdcccc;outline:1px solid #d8d8d8;margin:0;float:left;padding-top:4px;line-height:normal;z-index:2;left:4px;padding-bottom:3px;position:absolute;top:4px}.searchAutoCompleteProviderSelectorIE78:focus{width:auto;background-color:#fff}.msie78Search{width:190px}.ie8 .header_row_1.layout_cont_middle{clear:both!important}.ie8 .header_row_2.layout_cont_middle{margin-left:285px!important}.ie8 #meganav-content{display:block!important}.ie8 .hide-meganav #meganav-content{display:none!important}@media only screen and (-webkit-min-device-pixel-ratio:1.5){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:144dpi){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media only screen and (min-resolution:1.5dppx){.chosen-container .chosen-results-scroll-down span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container .chosen-results-scroll-up span{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-multi .chosen-choices .search-choice .search-choice-close{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single abbr{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-container-single .chosen-single div b{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}.chosen-rtl .chosen-search input[type=text]{background-image:url(/search/searchbar/resources/images/chosen-sprite@2x.png)!important;background-size:52px 37px!important;background-repeat:no-repeat!important}}@media (max-width:979px){.search form{background:#fff;height:auto;border:none!important;margin-top:0;margin:auto;width:100%}.search form input{box-sizing:border-box;line-height:40px;height:50px;width:100%!important;-webkit-appearance:none;-moz-appearance:none;appearance:none;border:1px solid #dcdcdc}.search form input.active input{height:50px}.search form input.selector-input-adjust{width:100%}.search form .search-button{display:none;position:absolute;top:273px;width:100%!important;height:46px;padding-top:0;color:#fff;line-height:46px;border-radius:3px 3px!important;margin:auto;left:0;right:0}.search form .search-button:hover{cursor:pointer}.search form .search-button img{display:none}.search form .search-btn-icon{right:14px;position:absolute;top:24px}.search form .searchAutoCompleteProviderSelector{top:0;width:100%!important;line-height:40px;height:40px;float:none}.search-container .search{display:none}.search-container.open .search{display:block;visibility:visible;opacity:1;position:fixed;z-index:1000;top:0;left:0;height:100%;width:100%;background-color:#fff;animation:fadeIn .5s}.container-modifier{padding:0!important}.typeahead-group{padding:5px 30px!important}.general_search.layout_cont_middle{margin-right:0}.header_row_2.layout_cont_left{width:95%;float:none;margin:auto;padding:0 15px 0 15px!important}.header_row_2.layout_cont_middle{width:95%;margin:auto;padding:0 15px 0 15px!important}.layout_cont_right{float:none;width:100%}#mobile-search-button-container{float:right;width:50px;height:60px;border-left:1px solid #eee;border-right:1px solid #eee}#search-mobile-button{display:block;height:60px;width:50px;border:none;background:0 0;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-search-black.svg);background-repeat:no-repeat;background-position:center;position:relative;left:0;margin-top:0}#search-mobile-button.active{border-bottom:3px solid #ee3134;background-image:url(/etc/designs/lifetech/clientlibs/base/img/icon-cross-black.svg);background-repeat:no-repeat;background-size:18px 18px}#focusAreaSelector{width:100%!important;margin:auto}#search-main.in{display:block;overflow:auto;overflow-x:hidden;position:fixed;z-index:200;bottom:0;top:61px;left:0;right:0;background:#fff}#search-main.in .searchHeading{display:block!important;padding:40px 0 24px 0;font-size:25.35px;color:#a2a2a2;text-align:center;font-weight:400}#search-main.in .searchHeading span{color:#333;font-weight:700}.global-commerce-bar .logo img{height:28px}#header-typeahead-input-container{width:100%;height:60px;left:0;right:0;margin:auto;padding:16px 0 16px 0;background:#fff}#header-typeahead{height:calc(100vh - 280px);width:100%;top:66px;margin:auto;left:0;right:0}}@media (min-width:992px){.header_row_2.layout_cont_wrapper{display:flex;flex-direction:row}.header_row_2.layout_cont_left,.header_row_2.layout_cont_middle{min-width:200px;padding:0!important}.header_row_2.layout_cont_middle{margin-left:0;width:100%}.search form{display:flex;width:100%}.searchHeading{display:none}.searchMagnifyMobile{display:none}header .search-container .search .search-button .search-text{display:none}.clearable{top:15px;right:24px}}.searchHeading p{padding:72px 36px 24px;font-size:22px;font-weight:500;line-height:28px;color:#92929e}.searchHeading p span{color:#000}.general_search.layout_cont_middle{order:-1;width:100%;margin-right:0;position:relative}header .search-layout .close{z-index:1001}.gsh-global-search-form-container .type-ahead-ctnr .keyword-container .dropdown-menu.ng-hide{display:none}.gsh-global-search-form-container .tf-filter-condensed-ctnr .tf-filter-box{height:48px!important}header .gsh-global-search-form-container .tf-filter-condensed-ctnr .filter-drop-down-ctnr{min-width:210px;margin-top:0;width:100%}#header-offer-bar{height:0;display:none}body{margin-top:60px}body .main-top-spacing{margin-top:60px}body .search-bg{top:60px}body.hide-header{margin-top:0}body.hide-header header{display:none}body.has-messaging-bar{margin-top:106px}body.has-messaging-bar .main-top-spacing{margin-top:106px}body.has-messaging-bar .search-bg{top:106px}body.spectraviewer{margin-top:60px}body.bootstrap-noconflict{padding-top:10px}@media (min-width:576px){#header-offer-bar{height:35px;display:block}body{margin-top:96px}body .main-top-spacing{margin-top:96px}body .search-bg{top:96px}body.has-messaging-bar{margin-top:141px}body.has-messaging-bar .main-top-spacing{margin-top:141px}body.has-messaging-bar .search-bg{top:141px}}@media (min-width:992px){body{margin-top:112px}body .main-top-spacing{margin-top:112px}body .search-bg{top:112px}body.has-messaging-bar{margin-top:157px}body.has-messaging-bar .main-top-spacing{margin-top:157px}body.has-messaging-bar .search-bg{top:157px}body.spectraviewer{margin-top:76px}}.clear:after,.clear:before,.clearfix:after,.clearfix:before,.group:after,.group:before,.result:after,.result:before{display:table;content:"";line-height:0}.clear:after,.clearfix:after,.group:after,.result:after{clear:both}.hide-text{font:0/0 a;color:transparent;text-shadow:none;background-color:transparent;border:0}.input-block-level{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box;display:block;width:100%;min-height:36px}#promoBar .promo-bar-snippet{background:#f3f3f3;line-height:35px;height:35px;font-size:15px;text-align:center;vertical-align:middle;display:block}#promoBar .promo-bar-snippet strong{color:#ee3134}#promoBar .promo-bar-snippet em{font-style:inherit;color:#c8c8c8;font-family:Arial,sans-serif;font-size:28px;vertical-align:bottom}#promoBar a.promo-bar-snippet{color:#000}#promoBar a.promo-bar-snippet:hover{color:#fff;background:#c8c8c8}#promoBar a.promo-bar-snippet:hover a,#promoBar a.promo-bar-snippet:hover em,#promoBar a.promo-bar-snippet:hover strong{color:#fff}#promoBar .promo-bar-snippet{overflow-x:auto;overflow-y:hidden;white-space:nowrap;padding:0 10px}#promoBar .promo-bar-snippet #promoBarContainer{padding:0 10px}#promoBar .promo-bar-snippet::-webkit-scrollbar{display:none}@media (max-width:767px){#promoBar .promo-bar-snippet{margin:0 -10px}}@media (max-width:479px){#promoBar{display:none!important}}#landscapeBanner{position:fixed;bottom:0;width:100%;z-index:9999}#landscapeBanner.author{position:relative;bottom:unset}#landscapeBanner #landscapeBannerContainer{background:#f3f3f3;border:1px solid #dcdcdc;height:60px;display:block}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{margin:auto}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{color:#222;font-size:22px;font-weight:500;line-height:60px;text-align:center;vertical-align:middle;display:block;font-family:HelveticaNeue,Helvetica,Roboto,"Segoe UI",Arial,sans-serif}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{margin-left:30px;font-size:14px;margin-bottom:5px;border-radius:3px!important}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button.btn-lb-light-gray{color:#1e8ae7}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button.btn-lb-light-gray:hover{background-color:#fff;border:1px solid #1e8ae7}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-button{background:#f3f3f3;position:absolute;top:1px;right:40px;width:60px;height:62px;border:none}@media only screen and (max-width:979px) and (min-width:480px){#landscapeBanner{left:0}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{margin-top:11px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{overflow-wrap:break-word;margin-left:1rem;line-height:normal;font-size:18px;width:85%}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{margin-left:20px}}@media only screen and (max-width:479px){#landscapeBanner{left:0}#landscapeBanner #landscapeBannerContainer{height:60px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent{width:auto;margin-top:14px;margin-left:1rem}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet{overflow-wrap:break-word;margin-left:.5rem;line-height:normal;font-size:14px;text-align:left;width:80%}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button{display:initial;padding:unset;border:none;background:unset;margin-left:8px}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-snippet #lb-button::after{content:"\203A"}#landscapeBanner #landscapeBannerContainer #landscapeBannerContent .landscape-banner-button{right:1px;border:none}}@media only screen and (min-width:980px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{width:164px;height:132px;padding:5px 5px 8px 7px;float:right}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (min-width:480px) and (max-width:767px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{width:164px;height:132px;padding:5px 5px 8px 7px;float:right}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (min-width:767px) and (max-width:979px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{visibility:hidden;width:0;height:0;display:none}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}@media only screen and (max-width:479px){#pdpOfferContainer{height:192px;border-style:solid;border-width:thin;border-color:#dcdcdc}#pdpOfferContainer.author{position:relative;bottom:unset}#pdpOfferContainer #pdpOffer-Content #pdp-image{visibility:hidden;width:0;height:0;display:none}#pdpOfferContainer button{width:auto;height:30px;white-space:nowrap;border-radius:3px;background-color:#555759;font-family:"Helvetica Neue",Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-size:11px;font-weight:700;font-style:normal;font-stretch:normal;line-height:normal;letter-spacing:normal;text-align:center;color:#fff;margin-left:13px;margin-bottom:24px;position:relative;margin-right:90%;text-decoration:none}#pdpOfferContainer .close{width:12px;height:22px;opacity:.5;color:#000;background-color:#fff;float:right;font-size:20px;font-weight:700;line-height:22px;margin-right:15px}}#searchOffer-container{background-color:#ebf2fa;padding:10px 10px 1px 10px;position:relative;margin-bottom:10px}#searchOffer-container.author{position:relative;bottom:unset}#searchOffer-container #searchOffer-title{display:inline-block;margin:0 0 8px 0;line-height:19px;font-family:"Helvetica Neue-Medium",Helvetica,Arial,sans-serif;text-decoration:none;font-size:16px;color:#1e8ae7}#searchOffer-container #searchOffer-title a:hover{color:#005daa}#searchOffer-container #search-subtitle{display:inline-block;font-family:"Helvetica Neue-Medium",Helvetica,Arial,sans-serif;font-size:14px;line-height:17px;margin-bottom:12px}.overlay-modal-body{max-width:950px;margin:0 auto;display:inline-block;padding-left:10px;display:none}@media only screen and (max-width:767px){#tf-cart-overlay-1 p#cart-text{padding-top:14px;padding-left:13px;float:left;text-align:left}#tf-cart-overlay-1 .chevroncont{margin-top:0;padding-top:0;float:left;padding-left:13px}.overlay-modal-body img{max-width:90%;height:auto}}@media only screen and (max-width:479px){#tf-cart-overlay-1{padding-right:10%}} /*# sourceMappingURL=header.min.css.map */ </style>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_1"); </script> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/utilities.min.468bd07150dbbf.js" async></script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_2"); </script>  <script data-inline-file-name='globalFunctions.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/globalFunctions.js */ function getCookie(key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0, l = cookies.length; i < l; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts.join('='); // Prevent storing or parsing of a cookie that we couldn't decode. if ( cookie && key === name ) { // removes surrounding quotes if ( cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters // cannot use decode_utf8 because it will escape the value try { cookie = decodeURIComponent(cookie); } catch (e){ } result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }; var setCookie = function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }; /** * get the domain based on a set of rules */ var getMasterDomain = function () { // default the domain var masterDomain = 'thermofisher.com'; // check for alternate domain. Upon match, the match[1] = domain_name, match[2] = domain_suffix var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { // add the parts of the match. (match[1] = domain_name) + (match[2] = domain_suffix) masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }; var decode_utf8 = function ( s ){ try { s= decodeURIComponent( escape( s ) ); } catch ( err ) {} return s; }; var isResponsive = function() { // Even if we have viewport tag, IE8 wont support. // This can go away.. eventually // Lazy IE8 check var isIE8 = window.attachEvent && !window.addEventListener; return !isIE8 && document.querySelectorAll('meta[name="viewport"]').length > 0; }; var getCurrentViewportSize = function() { var which = 'lg'; if ( isResponsive() ) { which = 'xl'; var breakpoints = { lg: 1200, md: 980, sm: 768, xs: 480 }; var width = window.innerWidth; for ( var w in breakpoints ) { if ( width < breakpoints[w] ) which = w; } } return which; }; function getQueryParam (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; };</script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_3"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_4"); </script>  <div id="header-offer-bar"> <div class="interactoffers"> <div class="dynamic-offer" id="tf-headerfooter-hb" data-placement-type="headerfooter" data-placement-code="hb" data-default-snippet=""> </div> </div> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_5"); </script> <script type="text/javascript"> var globalProviderConfig = { countryCode:'sg', langCode:'en', focusAreaPath:'/etc/thermo/endeca/focusAreas/default.html', items: [ { "group": null, "id": "all-categories", "title": "Search All", "searchURL": "/search/results?query={keyword}&focusarea={focusAreaName}", "typeAheadURL": "/search/service/typeaheadSuggestions?query={keyword}", "include": null, "exclude": null, "activation": null }, { "group": null, "id": "trial-catalog", "title": "Aspire Free Products", "searchURL": "/store/aspire/trials/searchTerm/{keyword}", "typeAheadURL": "/search/loyalty/service/typeahead?keyword={keyword}", "include": null, "exclude": null, "activation": ".*\/store\/aspire\/trials.*|.*LoyaltyDashboardDisplay.*|.*\/store\/aspire.*|.*LoyaltyRewardsDisplay.*" }, { "group": "Popular Product Areas", "id": "taqman-assays", "title": "TaqMan Assays", "searchURL": "/order/genome-database/searchResults?productTypeSelect=taqman&keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(\"TAQMAN\")", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/.*productTypeSelect.taqman.keyword.*|.*\/genome-database\/.*taqman*" }, { "group": "Popular Product Areas", "id": "gene-exp-assays", "title": "Gene Expression", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/ge/assays/ge_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22GE%22)", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/gene-expression\/.*|.*\/genome-database\/details\/gene-expression\/.*|.*\/genome-database\/.*ge_all.*|.*\/genome-database\/.*plate_all.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*" }, { "group": "Popular Product Areas", "id": "microbe-abr-detection", "title": "Microbe & ABR Detection", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/taqman/?keyword={keyword}&productSearch=microbe", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/order\/genome.*|.*\/microbe-detection\/taqman\/query\/.*|.*\/antibiotic-resistance\/taqman\/query\/.*|.*\/microbe-detection\/taqman\/target-list\/.*|.*\/home\/clinical\/clinical-genomics\/pathogen-detection-solutions.*", "exclude": ".*persona.DocSupport.*", "activation": null }, { "group": "Popular Product Areas", "id": "microbe-detection", "title": "Microbe Detection", "searchURL": "/microbe-detection/taqman/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/microbe-detection\/taqman\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/microbe-detection\/taqman\/query\/.*" }, { "group": "Popular Product Areas", "id": "antibiotic-resistance", "title": "Antibiotic Resistance", "searchURL": "/antibiotic-resistance/taqman/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22MCRB%22)", "include": ".*\/antibiotic-resistance\/taqman\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/antibiotic-resistance\/taqman\/query\/.*" }, { "group": "Popular Product Areas", "id": "crispr-guide-rna", "title": "CRISPR Guide RNA", "searchURL": "/crispr/invitrogen/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22CRSPR%22)", "include": ".*\/crispr\/.*|.*\/geneart.crispr\/.*|.*\/genome.editing\/geneart.crispr\/crispr.libraries\/lentiarray.crispr.libraries\/lentiarray.grnas.*|.*\/genome.database\/browse\/trueguide\/.*|.*\/genome.database\/browse\/lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.true.guide.sgrna.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/crispr\/.*|.*\/geneart.crispr\/.*|.*\/genome.editing\/geneart.crispr\/crispr.libraries\/lentiarray.crispr.libraries\/lentiarray.grnas.*|.*\/genome.editing\/geneart.crispr\/crispr.grna.*|.*\/genome.database\/browse\/trueguide\/.*|.*\/genome.database\/browse\/lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.lentiviral.*|.*productTypeSelect.crspr.targetTypeSelect.crspr.true.guide.sgrna.*" }, { "group": "Popular Product Areas", "id": "copy-number-variation", "title": "Copy Number Variation", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/cnv/assays/cnv_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22CNV%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/cnv\/.*|.*\/genome-database\/details\/cnv\/.*|.*\/genome-database\/.*cnv_all.*" }, { "group": "Popular Product Areas", "id": "mutation-detection", "title": "Mutation Detection", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/mutation/assays/mutation_castPCR/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22CPCR%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/mutation-detection\/.*|.*\/genome-database\/details\/DPCR\/.*|.*\/genome-database\/.*mutation_digitalPCR.*" }, { "group": "Popular Product Areas", "id": "mirna", "title": "miRNA", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/microrna/assays/microrna_mature/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filters=filter1%3A(%22MIRNA%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/.*microrna_mature.*|.*\/genome-database\/.*microrna_advanced.*|.*\/genome-database\/.*microrna_all.*" }, { "group": "Popular Product Areas", "id": "snp-genotyping", "title": "SNP Genotyping", "searchURL": "/order/genome-database/?pearUXVerSuffix=pearUX2&elcanoForm=true#!/genotyping/assays/genotyping_all/?keyword={keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=%E2%80%9C&filters=filter1%3A(%22GT%22)%E2%80%9D", "include": ".*\/order\/genome.*|.*\/taqman-gene-expression\/product\/.*|.*\/taqman-gene-expression\/query\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/genome-database\/browse\/genotyping\/.*|.*\/genome-database\/details\/genotyping\/.*|.*\/genome-database\/.*genotyping_all.*|.*\/genome-database\/.*productTypeSelect=genotyping.*" }, { "group": "Popular Product Areas", "id": "primary-antibodies", "title": "Primary Antibodies", "searchURL": "/antibody/primary/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22PRANT%22)+AND+filter3%3A(%22Pri-Anti%22)", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies.html|.*\/home\/life-science\/antibodies\/primary.*|.*\/home\/life-science\/antibodies\/invitrogen-antibody-validation.*|.*\/antibody\/primary.*|.*\/antibody\/product\/.*-.ntibody.*|.*\/home\/life-science\/cell-analysis\/flow-cytometry\/antibodies-for-flow-cytometry.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/antibody\/sitemap\/Primary-Antibodies-.*|.*\/antibody\/target\/.*|.*\/antibody\/gene\/.*|.*\/home\/life-science\/protein-biology\/protein-assays-analysis\/western-blotting\/detect-proteins-western-blot\/western-blot-detection-reagents\/western-blot-antibodies.*|.*\/home\/life-science\/antibodies\/primary-antibodies\/control-antibodies\/loading-control-antibodies.*" }, { "group": "Popular Product Areas", "id": "secondary-antibodies", "title": "Secondary Antibodies", "searchURL": "/antibody/secondary/query/{keyword}", "typeAheadURL": null, "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/secondary.*|.*\/antibody\/secondary.*|.*\/antibody\/product\/.*-.econdary-.ntibody.*|.*\/antibody\/sitemap\/Secondary-Antibodies-.*" }, { "group": "Popular Product Areas", "id": "isotype-controls", "title": "Isotype Controls", "searchURL": "/antibody/control/query/{keyword}", "typeAheadURL": null, "include": ".*\/antibody\/.*|.*\/elisa\/product\/.*|\/order\/genome.*|.*-.ntibody.*|.*-.rotein.*|.*-.eptide.*|.*-.ontrol.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/proteins\/.*|.*\/immunoassays\/.*|.*\/elisa\/product\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/primary-antibodies\/control-antibodies.*|.*\/antibody\/product\/.*-.ontrol\/.*|.*\/antibody\/control\/.*|.*\/antibody\/sitemap\/Control-Antibodies-.*" }, { "group": "Popular Product Areas", "id": "proteins-and-peptides", "title": "Proteins & Peptides", "searchURL": "/proteins/query/{keyword}", "typeAheadURL": "/order/genome-database/keywordTypeAhead?query={keyword}&wt=json&indent=on&version=2.2&start=0&rows=15&fl=value%2Ctype&qt=standard&filters=filter1%3A(%22PRANT%22)+AND+filter3%3A(%22Sec-Anti%22)", "include": ".*\/proteins\/.*|.*\/antibody\/.*|.*\/elisa\/product\/.*|.*\/order\/genome.*|.*-.ntibody.*|.*-.rotein.*|.*-.eptide.*|.*-.ontrol.*|.*\/home\/order\/antibodies-immunoassays.html|.*\/immunoassays\/.*|.*\/elisa\/product\/.*", "exclude": ".*persona.DocSupport.*", "activation": ".*\/proteins\/.*|.*\/query\/.*-.ecombinant-.rotein\/.*|.*\/proteins\/query\/.*-.ynthetic-.eptide\/.*|.*\/proteins\/query\/.*-.ative-.rotein\/.*" }, { "group": "Popular Product Areas", "id": "elisa-kits", "title": "ELISA Kits", "searchURL": "/immunoassays/elisa/query/{keyword}", "typeAheadURL": "/order/genome-database/typeAheadSearch?keyword={keyword}&productSubType=elisa", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/home\/life-science\/antibodies\/immunoassays\/elisa-kits.*|.*\/elisa\/product\/.*|.*\/immunoassays\/elisa\/query\/.*|.*\/immunoassays\/elisa\/target\/.*|.*\/immunoassays\/target\/.*" }, { "group": null, "id": "all-documents-support", "title": "All Documents & Support", "searchURL": "/search/results?query={keyword}&persona=DocSupport", "typeAheadURL": "n/a", "include": null, "exclude": ".*persona.DocSupport.*", "activation": ".*\/search\/results.query.*persona.DocSupport.*" }, { "group": null, "id": "certificates", "title": "Certificates", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ACertificates", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837200.*|.*docTypes=COA.*|.*filter.document.result.type.*Certificates.*" }, { "group": null, "id": "sds", "title": "SDS", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3ASDS&refinementAction=true", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837192.*|.*docTypes=SDS.*|.*filter.document.result.type.*SDS.*" }, { "group": null, "id": "manuals-and-protocols", "title": "Manuals & Protocols", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AManuals%20%26%20Protocols", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837203.*|.*docTypes.Manuals.*|.*filter.document.result.type.*Manuals.*Protocols.*" }, { "group": null, "id": "support-files", "title": "Support Files", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ASupport%20Files", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837196.*|.*docTypes.SupportFiles.*|.*filter.document.result.type.*Support.*Files.*" }, { "group": null, "id": "product-literature", "title": "Product Literature", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AProduct%20Literature", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837193.*|.*docTypes.Brochures.*|.*filter.document.result.type.*Product.*Literature.*" }, { "group": null, "id": "citations-and-references", "title": "Citations & References", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3ACitations%20%26%20References", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294845218.*|.*docTypes.Citations.*|.*filter.document.result.type.*Citations.*References.*" }, { "group": null, "id": "product-faqs", "title": "Product FAQs", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AProduct%20FAQs", "typeAheadURL": null, "include": null, "exclude": null, "activation": ".*4294837268.*|.*docTypes.FAQ.*|.*filter.document.result.type.*Product.*FAQs.*" }, { "group": null, "id": "ordering-and-web-faqs", "title": "Ordering & Web FAQs", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3AOrdering%20%26%20Web%20FAQs&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*navId.4294837259.*|.*filter.document.result.type.*Ordering.*Web.*FAQs.*" }, { "group": null, "id": "media-formulations", "title": "Media Formulations", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3AMedia%20Formulations&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837198.*|.*docTypes.MediaFormulation.*|.*filter.document.result.type.*Media.*Formulations.*" }, { "group": null, "id": "molecular-probes-handbook", "title": "Molecular Probes Handbook", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AMolecular%20Probes%20Handbook", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837201.*|.*docTypes.Probes.*Handbook.*|.*filter.document.result.type.*Molecular.*Probes.*Handbook.*" }, { "group": null, "id": "spectra-data", "title": "Spectra Data", "searchURL": "/search/results?query={keyword}&persona=DocSupport&filter=document.result_type_s%3ASpectra%20Data&refinementAction=true", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837270.*|.*docTypes.Probes.*Spectra.*|.*filter.document.result.type.*Spectra.*Data.*" }, { "group": null, "id": "vector-data", "title": "Vector Data", "searchURL": "/search/results?query={keyword}&persona=DocSupport&refinementAction=true&filter=document.result_type_s%3AVector%20Data", "typeAheadURL": null, "include": ".*persona.DocSupport.*", "exclude": null, "activation": ".*4294837191.*|.*docTypes.Vectors.*|.*filter.document.result.type.*Vector.*Data.*" } ] }; </script> <div class="main-header-container">  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_6"); </script>  <div id="nav-container" class="nav-container pragma-toggle-component"> <span class="sr-only">Hamburger Menu Button</span> <div id="hamburger-btn" class="menu hamburger-btn pragma-toggle" data-toggle="#nav-container,#full-bg" data-toggle-classes="open" tabindex="0"> <span class="icon"></span> </div> <nav id="mega-nav" class="mega-nav"> <span class="close pragma-toggle" data-toggle="#nav-container,#full-bg" data-toggle-classes="open"></span>  <span class="logo"> <a rel="home" href="/sg/en/home.html" id="hfLifetechLogoLinkSideNav"> <svg id="Layer_1" data-name="Layer 1" aria-labelledby="logo-alt" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <title id="logo-alt">Thermo Fisher Scientific Logo</title> <defs> <style> .tf-logo-cls-1 { fill: #E71316; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55" /> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z" /> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z" /> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2" /> </svg> </a> </span> <div class="account-dd"> <div class="account"> <div class="cmp-p-ctaitem m--btn-primary m--block"> <div class="cmp-ctaitem"> <a class="cmp-ctaitem__anchor" href="/auth/initiate"> <span class="cmp-ctaitem__text">Sign in</span> </a> </div> </div> <div class="create-account pt-l1 pb-l1 border-bottom">Don't have an account ? <a href="/auth/create-account">Create Account</a> </div> <div class="create-account"> </div> </div> </div> <ul id='primary-nav' class='main-nav' data-analytics-section='top'> <li id='primary-link-1' class='main-nav-item pragma-toggle' data-toggle='#primary-link-1,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Products' tabindex='0'> <span class='arrow'></span>Products <ul id='secondary-nav-1' class='sub-nav'> <li id='secondary-link-1-1' > <a href='/sg/en/home/life-science/antibodies.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Antibodies'> Antibodies </a> </li> <li id='secondary-link-1-2' > <a href='/search/browse/category/us/en/90217060' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Cell Culture Media'> Cell Culture Media </a> </li> <li id='secondary-link-1-3' > <a href='/sg/en/home/chemicals.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Chemicals'> Chemicals </a> </li> <li id='secondary-link-1-4' > <a href='/search/browse/category/us/en/90155038' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Western Blot Products'> Western Blot Products </a> </li> <li id='secondary-link-1-5' > <a href='/search/browse/category/us/en/90126197' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Chromatography Columns and Cartridges'> Chromatography Columns and Cartridges </a> </li> <li id='secondary-link-1-6' > <a href='/sg/en/home/life-science/lab-equipment.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Lab Equipment'> Lab Equipment </a> </li> <li id='secondary-link-1-7' > <a href='/sg/en/home/life-science/lab-plasticware-supplies.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Lab Plasticware and Supplies'> Lab Plasticware and Supplies </a> </li> <li id='secondary-link-1-8' > <a href='/search/browse/category/us/en/90111007' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Microplates'> Microplates </a> </li> <li id='secondary-link-1-9' > <a href='/sg/en/home/life-science/oligonucleotides-primers-probes-genes.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Oligos, Primers, Probes and Genes'> Oligos, Primers, Probes and Genes </a> </li> <li id='secondary-link-1-10' > <a href='/sg/en/home/life-science/pcr/real-time-pcr/real-time-pcr-assays.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='TaqMan Real-Time PCR Assays'> TaqMan Real-Time PCR Assays </a> </li> <li id='secondary-link-1-11' > <a href='/sg/en/home/sustainable-design' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='Greener Products'> Greener Products </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/order.html' data-analytics-section='top' data-analytics-parent='Products' data-analytics-text='See all product categories'> See all product categories <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-2' class='main-nav-item pragma-toggle' data-toggle='#primary-link-2,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Applications' tabindex='0'> <span class='arrow'></span>Applications <ul id='secondary-nav-2' class='sub-nav'> <li id='secondary-link-2-1' > <a href='/sg/en/home/life-science/bioproduction.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Bioprocessing'> Bioprocessing </a> </li> <li id='secondary-link-2-2' > <a href='/sg/en/home/life-science/cell-culture.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Cell Culture and Transfection'> Cell Culture and Transfection </a> </li> <li id='secondary-link-2-3' > <a href='/content/lifetech/global/en/home/industrial/food-beverage.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Food and Beverage'> Food and Beverage </a> </li> <li id='secondary-link-2-4' > <a href='/content/lifetech/global/en/home/lab-solutions.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Lab Solutions'> Lab Solutions </a> </li> <li id='secondary-link-2-5' > <a href='/content/lifetech/global/en/home/industrial/pharma-biopharma.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Pharma and Biopharma'> Pharma and Biopharma </a> </li> <li id='secondary-link-2-6' > <a href='/content/lifetech/global/en/home/life-science/pcr/real-time-pcr.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Real-Time PCR'> Real-Time PCR </a> </li> <li id='secondary-link-2-7' > <a href='/sg/en/home/semiconductors.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Semiconductor Analysis'> Semiconductor Analysis </a> </li> <li id='secondary-link-2-8' > <a href='/content/lifetech/global/en/home/clinical.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Clinical and Diagnostics'> Clinical and Diagnostics </a> </li> <li id='secondary-link-2-9' > <a href='/sg/en/home/digital-solutions.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Digital Solutions'> Digital Solutions </a> </li> <li id='secondary-link-2-10' > <a href='/sg/en/home/industrial/spectroscopy-elemental-isotope-analysis.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='Spectroscopy, Elemental and Isotope Analysis'> Spectroscopy, Elemental and Isotope Analysis </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/applications-techniques.html' data-analytics-section='top' data-analytics-parent='Applications' data-analytics-text='See all applications and techniques'> See all applications and techniques <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-3' class='main-nav-item pragma-toggle' data-toggle='#primary-link-3,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Services' tabindex='0'> <span class='arrow'></span>Services <ul id='secondary-nav-3' class='sub-nav'> <li id='secondary-link-3-1' > <a href='/sg/en/home/products-and-services/services/crdmo.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Integrated CDMO-CRO Services'> Integrated CDMO-CRO Services </a> </li> <li id='secondary-link-3-2' > <a href='/sg/en/home/brands/patheon.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='CDMO Services'> CDMO Services </a> </li> <li id='secondary-link-3-3' > <a href='https://www.ppd.com/' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='CRO Services'> CRO Services </a> </li> <li id='secondary-link-3-4' > <a href='/sg/en/home/products-and-services/services/custom-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Custom Services'> Custom Services </a> </li> <li id='secondary-link-3-5' > <a href='/sg/en/home/products-and-services/services/enterprise-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Enterprise Services'> Enterprise Services </a> </li> <li id='secondary-link-3-6' > <a href='/sg/en/home/products-and-services/services/financial-leasing-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Financial and Leasing Services'> Financial and Leasing Services </a> </li> <li id='secondary-link-3-7' > <a href='/sg/en/home/products-and-services/services/instrument-qualification-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Instrument Services'> Instrument Services </a> </li> <li id='secondary-link-3-8' > <a href='/sg/en/home/digital-solutions/lab-informatics.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Lab Informatics'> Lab Informatics </a> </li> <li id='secondary-link-3-9' > <a href='/sg/en/home/about-us/partnering-licensing/oem-commercial-supply.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='OEM and Commercial Supply'> OEM and Commercial Supply </a> </li> <li id='secondary-link-3-10' > <a href='/sg/en/home/products-and-services/services/training-services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='Training Services'> Training Services </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/products-and-services/services.html' data-analytics-section='top' data-analytics-parent='Services' data-analytics-text='See all services'> See all services <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-4' class='main-nav-item pragma-toggle' data-toggle='#primary-link-4,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Help and Support' tabindex='0'> <span class='arrow'></span>Help and Support <ul id='secondary-nav-4' class='sub-nav'> <li id='secondary-link-4-1' > <a href='/sg/en/home/support/how-to-register-for-account.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Order Help'> Order Help </a> </li> <li id='secondary-link-4-2' > <a href='/sg/en/home/digital-solutions.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Digital Solutions'> Digital Solutions </a> </li> <li id='secondary-link-4-3' > <a href='/sg/en/home/technical-resources/instrument-support.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Product Support'> Product Support </a> </li> <li id='secondary-link-4-4' > <a href='/sg/en/home/technical-resources/technical-reference-library.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Technical Information'> Technical Information </a> </li> <li id='secondary-link-4-5' > <a href='/sg/en/home/technical-resources/learning-centers.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='Training and Education'> Training and Education </a> </li> <li> <span class='see-all'> <a href='/sg/en/home/support.html' data-analytics-section='top' data-analytics-parent='Help and Support' data-analytics-text='See all help and support topics'> See all help and support topics <span class='right-arrow'></span> </a> </span> </li> </ul> </li> <li id='primary-link-5' class='main-nav-item pragma-toggle' data-toggle='#primary-link-5,nav' data-toggle-classes='open' data-analytics-section='top' data-analytics-parent='Popular' tabindex='0'> <span class='arrow'></span>Popular <ul id='secondary-nav-5' class='sub-nav'> <li id='secondary-link-5-1' class='popular' > <a href='/sg/en/home/life-science/pcr/real-time-pcr/real-time-pcr-assays.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='TaqMan Real-Time PCR Assays'> <div> <img src='/content/dam/LifeTech/global/home-page/2019/taqman-hr-meganav.jpg' class='popular-image' loading='lazy' alt='TaqMan Real-Time PCR Assays'/> </div> <div class='pl-12'>TaqMan Real-Time PCR Assays</div> </a> </li> <li id='secondary-link-5-2' class='popular' > <a href='/sg/en/home/life-science/antibodies.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Antibodies'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular2-175x115.gif' class='popular-image' loading='lazy' alt='Antibodies'/> </div> <div class='pl-12'>Antibodies</div> </a> </li> <li id='secondary-link-5-3' class='popular' > <a href='/sg/en/home/life-science/oligonucleotides-primers-probes-genes' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Oligos, Primers & Probes'> <div> <img src='/content/dam/LifeTech/global/home-page/images/oligos-main-popular.jpg' class='popular-image' loading='lazy' alt='Oligos, Primers & Probes'/> </div> <div class='pl-12'>Oligos, Primers & Probes</div> </a> </li> <li id='secondary-link-5-4' class='popular' > <a href='/sg/en/home/life-science/cloning/gene-synthesis/geneart-gene-synthesis.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='GeneArt Gene Synthesis'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular4-175x115.jpg' class='popular-image' loading='lazy' alt='GeneArt Gene Synthesis'/> </div> <div class='pl-12'>GeneArt Gene Synthesis</div> </a> </li> <li id='secondary-link-5-5' class='popular' > <a href='/sg/en/home/life-science/cell-culture/cell-culture-plastics.html' data-analytics-section='top' data-analytics-parent='Popular' data-analytics-text='Cell Culture Plastics'> <div> <img src='/content/dam/LifeTech/global/promotions/meganav/2017/01-Jan/popular5-175x115.jpg' class='popular-image' loading='lazy' alt='Cell Culture Plastics'/> </div> <div class='pl-12'>Cell Culture Plastics</div> </a> </li> </ul> </li> </ul> <ul class='support'> <li id='support-links-1'> <a href='/sg/en/home/technical-resources/contact-us.html' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Contact Us'>Contact Us</a> </li> <li id='support-links-2'> <a href='/store/v2/quick-order' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Quick Order'>Quick Order</a> </li> <li id='support-links-3'> <a href='/store/orders/solu' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Order Status and Tracking'>Order Status and Tracking</a> </li> <li id='support-links-4'> <a href='/sg/en/home/support/documents-certificates.html' data-analytics-section='top' data-analytics-parent='mega-nav' data-analytics-text='Documents and Certificates'>Documents and Certificates</a> </li> </ul>  </nav>  <span class="logo"> <a rel="home" href="/sg/en/home.html" id="hfLifetechLogoLink"> <svg id="Layer_1" data-name="Layer 1" aria-labelledby="logo-alt" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <title id="logo-alt">Thermo Fisher Scientific Logo</title> <defs> <style> .tf-logo-cls-1 { fill: #E71316; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55" /> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z" /> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z" /> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2" /> </svg> </a> </span> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_7"); </script> <div class="search-container"> <div class="search-layout">  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_8"); </script> <script src="/search/static/resources/js/signals.min.js" async></script> <script> var translations = {}; if ("prod" === "qa1" || "prod" === "qa4") { useV2Script = true; if (getCookie('enableSsi') === 'false') { useV2Script = false; } } else { useV2Script = "true" === "true"; if (getCookie('enableSsi') === 'false') { useV2Script = false; } else if (getCookie('enableSsi') === 'true') { useV2Script = true; } } var host = ''; if ("false" === true || "false" === 'true') { host = "//www.thermofisher.com"; } var searchEndpoint = '' if (useV2Script) { searchEndpoint = host + "/search/searchbar/resources/js/searchbarv2.js"; } else { searchEndpoint = host + "/search/searchbar/resources/js/searchbar.min.js"; } var script = document.createElement('script'); script.setAttribute('src', searchEndpoint); script.setAttribute('async', ''); var searchLayout = document.getElementsByClassName('search-layout'); if (searchLayout.length > 0) { searchLayout[0].appendChild(script); } else { document.body.appendChild(script); } </script> <script> var translations = { search: "Search by catalog number, product name, keyword, application", searchAll: "Search All", searchButton: "Search", searchIn: "Search within ", recentSearch: "Recent searches", moreWaysToSearch: "More ways to search", }; </script> <div class="search"> <div class="largeSearchBar" id="search-main"> <div class="searchHeading"> <p>Search <span>Thermo Fisher Scientific</span> </p> </div> <div id="searchModalBody" class="header_row_2 layout_cont_wrapper"> <div class="header_row_2 layout_cont_left" tabindex="0"> <div id="focusAreaSelector"> <div class="chosen-container chosen-container-single chosen-container-single-nosearch" style="width: 100%;" title="" id="chosenselector_chosen"><a class="chosen-single" tabindex="-1"><span>Search All </span> <div><b></b></div> </a></div> </div> </div> <div class="header_row_2 layout_cont_right"> </div> <div class="header_row_2 layout_cont_middle"> <div id="generalSearch" class="general_search layout_cont_wrapper"> <form id="smartsearch" method="get" autocomplete="off"> <input type="hidden" value="1" name="resultPage"> <input type="hidden" value="15" name="resultsPerPage"> <div class="general_search layout_cont_left"> </div> <div class="general_search layout_cont_right"> <button id="searchButton" type="submit" class="search-button" formaction="/search/results" tabindex="-1"> <p class="search-text">Search</p> <svg class="search-btn-icon" role="img" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xml:space="preserve"><defs><style>.cls-1-white{fill:#FFFFFF;}</style></defs><title>Search button</title><g id="Layer_462" data-name="Layer 462"><path class="cls-1-white" d="M27.49,26.45l-6.34-6.34a9.71,9.71,0,0,0-.31-13.42,9.76,9.76,0,0,0-13.77,0A9.73,9.73,0,0,0,19.66,21.45l6.41,6.42ZM8.48,19A7.73,7.73,0,1,1,14,21.31,7.68,7.68,0,0,1,8.48,19Z"/></g></svg> </button> </div> <div class="general_search layout_cont_middle"> <div id="generalSearchInput"> <div id="header-typeahead-input-container"> <input type="text" class="data-hj-whitelist" id="suggest1" name="query" accesskey="s" value="" role="search" autocomplete="off" placeholder="Search by catalog number, product name, keyword, application" tabindex="0"> <input type="text" id="header-typeahead-suggested" autocomplete="off" /> </div> <i id="searchMagnifyMobile" class="searchMagnifyMobile"> <svg class="search-btn-icon" role="img" version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" xml:space="preserve"><defs><style>.cls-1-grey{fill:#70707A;}</style></defs><title>Search button</title><g id="Layer_462" data-name="Layer 462"><path class="cls-1-grey" d="M27.49,26.45l-6.34-6.34a9.71,9.71,0,0,0-.31-13.42,9.76,9.76,0,0,0-13.77,0A9.73,9.73,0,0,0,19.66,21.45l6.41,6.42ZM8.48,19A7.73,7.73,0,1,1,14,21.31,7.68,7.68,0,0,1,8.48,19Z"/></g></svg> </i> <i id="searchRemove" class="clearable searchRemoveHide"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 28 18"><defs><style>.cls-1-grey{fill:#54545C;}</style></defs><title>Close</title><g id="Layer_154" data-name="Layer 154"><path class="cls-1-grey" d="M9.40199 0L0.148438 8.82L9.40199 17.64H27.8147V0H9.40199ZM25.7164 15.64H10.2623L3.10706 8.82L10.2623 2H25.7164V15.64ZM12.0773 12.09L15.5081 8.82L12.0773 5.63L13.5567 4.22L16.9454 7.45L20.3342 4.22L21.824 5.63L18.4772 8.82L21.866 12.05L20.3762 13.47L16.9874 10.24L13.5986 13.47L12.0773 12.09Z"/></g></svg> </i> <div id="header-typeahead"> <input type="hidden" id="typeahead-autocomplete" name="autocomplete" /> <div> <ul class="flyout-recent-searches hide"></ul> </div> <div class="flyout-typeahead"> <div class="typeahead-terms"><ul class="typeahead-term-list"></ul></div> <div class="flyout-search-shortcut_right"> <ul class="search-shortcut-list"></ul> </div> </div> <div class="flyout-search-shortcut"> <ul class="search-shortcut-list"></ul> </div> </div> </div> </div> </form> </div> <span class="loading-wheel-sm hidden"></span> <div id="primarySearch"> </div> </div> <div class="clear"></div> </div> </div> <div class="global-commerce-bar-spacing"></div> </div> <input type="hidden" id="clientTranslations" value='{"search":"Search by catalog number, product name, keyword, application","searchAll":"Search All","searchButton":"Search","searchIn":"Search within ","recentSearch":"Recent searches","moreWaysToSearch":"More ways to search"}'/>  <script data-inline-file-name='searchbar.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/searchbar.min.js */ window.searchbar={init:function(){performance.mark("enter_initSearchbar()");try{console.log("searchbar_init - attempting to initialize globalProviderConfig...");var e=window.globalProviderConfig;console.log("searchbar_init - globalProviderConfig: {\n\t focusAreaPath: "+e.focusAreaPath+",\n\t countryCode: "+e.countryCode+",\n\t langCode: "+e.langCode+",\n\t items: "+e.items.length+"\n}")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load translations..."),translations=JSON.parse(document.getElementById("clientTranslations").value),console.info("searchbar_init - translations load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load searchSelector..."),thermofisher.search.searchSelector.init(),console.info("searchbar_init - searchSelector load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}if(!1===useV2Script)try{console.info("searchbar_init - attempting to load searchFocusArea..."),thermofisher.search.searchFocusArea.init(),console.info("searchbar_init - searchFocusArea load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load searchProvider..."),thermofisher.search.searchProvider.init(),console.info("searchbar_init - searchProvider load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}try{console.info("searchbar_init - attempting to load SignalsStatic..."),thermofisher.search.SignalsStatic.init(),console.info("searchbar_init - SignalsStatic load complete!")}catch(e){console.error("ERROR: searchbar_init ",e)}console.info("searchbar_init - all loading complete!"),performance.mark("exit_initSearchbar()"),performance.mark("exit_initSearchBarAfterEvent()"),performance.measure("searchbar_init__initSearchBarAfterEvent()","enter_initSearchBarAfterEvent()","exit_initSearchBarAfterEvent()"),performance.measure("searchbar_init__initSearchbar()","enter_initSearchbar()","exit_initSearchbar()")}};</script> <script type="text/javascript"> var whenJqueryReadyInterval = null; // used to "break" the jquery check loop document.addEventListener('DOMContentLoaded', function initSearchBarAfterEvent() { // load searchbar resources after page finishes loading performance.mark('enter_initSearchBarAfterEvent()'); var whenJqueryReadyInterval = setInterval(function initSearchBarAfterJqueryLoad() { // load searchbar resources only after jQuery is ready // performance.mark('enter_initSearchBarAfterJqueryLoad()'); if (window.useV2Script) { console.log("[Searchbar]Using V2 Script"); if (!window.thermofisher || !window.thermofisher.search || !window.thermofisher.search.searchSelector || !window.thermofisher.search.searchProvider || !window.thermofisher.search.SignalsStatic){ return; } console.info('searchbar_init - Using v2 - no jQuery needed!'); window.searchbar.init(); clearInterval(whenJqueryReadyInterval); whenJqueryReadyInterval = null; } else { console.log("[Searchbar]Using jQuery"); if (window.jQuery && (!window.thermofisher || !window.thermofisher.search || !window.thermofisher.search.searchSelector || !window.thermofisher.search.searchProvider || !window.thermofisher.search.SignalsStatic || !window.thermofisher.search.searchFocusArea)){ return; } console.info('searchbar_init - jQuery loaded!'); window.searchbar.init(); clearInterval(whenJqueryReadyInterval); whenJqueryReadyInterval = null; } }, 100); }); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_9"); </script> </div> <span class="close" tabindex="0"></span> <span class="search-icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24"><path class="cls-1" d="M20.79,19.66l-4.58-4.58a7.53,7.53,0,1,0-1.49,1.34l4.66,4.66ZM6.54,14.11a5.56,5.56,0,1,1,3.93,1.62A5.52,5.52,0,0,1,6.54,14.11Z"/> </svg> </span> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_10"); </script> <div class="info-container" id="commerce-bar"> <ul>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_11"); </script> <li id="order-status-1" class="order-status" data-util-index="1" data-analytics-text="Order Status"> <a class="user-utility-link cloud-button" href="/store/orders/solu">Order Status</a> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_12"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_13"); </script> <li id="quick-order" class="quick-order" data-util-index="4" data-analytics-text="Quick Order"> <a href="/store/v2/quick-order"> Quick Order </a> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_14"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_15"); </script> <li id="sign-in" class="account pragma-toggle-component" data-util-index="3" data-analytics-text="Sign in"> <span id="sign-in-toggle" class="down-caret-icon pragma-toggle" data-toggle="#sign-in,#full-bg" data-toggle-classes="open"> Sign in </span>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_16"); </script> <div class="account-dd"> <div class="account"> <div class="cmp-p-ctaitem m--btn-primary m--block"> <div class="cmp-ctaitem"> <a class="cmp-ctaitem__anchor" href="/auth/initiate"> <span class="cmp-ctaitem__text">Sign in</span> </a> </div> </div> <div class="create-account pt-l1 pb-l1 border-bottom">Don't have an account ? <a href="/auth/create-account">Create Account</a> </div> <div class="create-account"> <ul> <li class="loyalty-text"><a href="#"></a></li> <li class="points"><a href="#"></a></li> <li> <a href="/auth/initiate">Account</a> </li> <li> <a href="/store/orders/solu">Check Order Status</a> </li> <li> <a href="https://apps.thermofisher.com ">Connect: Lab, Data, Apps</a> </li> <li> <a href="/auth/initiate">Custom Products & Projects</a> </li> <li> <a href="/auth/initiate">Instrument Management</a> </li> </ul>  </div> </div> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_17"); </script> </li>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_18"); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_19"); </script> <li class="cart" data-util-index="5"> <a class = "pragma-remote-request" id="cart-link" href ="javascript:void(0)" data-remote-url = "/store/v2/minicart" data-remote-container ="#cart-sidebar" data-remote-failure-url="/store/cart"> <span class="count"></span> <svg data-toggle="#cart-sidebar,#full-bg" data-toggle-classes="open" class="pragma-toggle pragma-toggle-component" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 32 32"> <path class="cls-1" d="M11,25.55A1.76,1.76,0,1,1,9.27,23.8,1.76,1.76,0,0,1,11,25.55ZM24.65,23.8a1.76,1.76,0,1,0,1.76,1.75A1.75,1.75,0,0,0,24.65,23.8Zm1.46-2L29.46,9.64H10.24l.61,2.16H26.63l-2.16,7.81H9.76L5.59,4.94h-4l.62,2.15H4L8.14,21.77Z"/> </svg> </a> </li> </ul>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_20"); </script> <div id="cart-sidebar" class="cart-dd pragma-toggle-component"> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_21"); </script> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_22"); </script>  <script data-inline-file-name='utilitybarbase.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/utilitybarbase.min.js */ var utilitybarBase=function(e){return e.$utilityBar=document.getElementById("user-utility-bar"),e.$quickOrder=document.getElementById("hfBarQuickOrder"),e.$cloudLink=document.getElementById("hfCloud"),e.$accountDropdown=document.querySelectorAll("#hfGreetAnonymous,#hfGreetByName")[0],e.$partnerDashboard=document.querySelectorAll("#hfGreetDashboard")[0],e.$miniCart=document.getElementById("miniCartButton"),e.$viewNotifications=document.getElementById("notification-link"),e.$drawer1=document.getElementById("mobile-nav-drawer-1"),e.$drawer2=document.getElementById("mobile-nav-drawer-2"),e.Large=function(){e.$partnerDashboard&&e.$utilityBar.appendChild(e.$partnerDashboard),e.$cloudLink&&e.$utilityBar.appendChild(e.$cloudLink),e.$quickOrder&&e.$utilityBar.appendChild(e.$quickOrder),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications),e.$accountDropdown&&e.$utilityBar.appendChild(e.$accountDropdown)},e.Medium=function(){e.$accountDropdown&&e.$drawer2.appendChild(e.$accountDropdown),e.$partnerDashboard&&e.$drawer2.appendChild(e.$partnerDashboard),e.$quickOrder&&e.$utilityBar.appendChild(e.$quickOrder),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications)},e.Small=function(){e.$accountDropdown&&e.$drawer2.appendChild(e.$accountDropdown),e.$partnerDashboard&&e.$drawer2.appendChild(e.$partnerDashboard),e.$miniCart&&e.$utilityBar.appendChild(e.$miniCart),e.$viewNotifications&&!document.documentMode&&e.$utilityBar.appendChild(e.$viewNotifications),e.$quickOrder&&e.$drawer1.appendChild(e.$quickOrder)},e.init=function(){switch(currentBreakpoint=getCurrentViewportSize(),currentBreakpoint){case"xl":case"lg":e.Large();break;case"md":case"sm":e.Medium();break;case"xs":e.Small()}},e.initMiniCartCount=function(){var e=".minicart-number-holder-"+(window.innerWidth<=979?"mobile":"desktop"),i=document.querySelector(e),t=null!=i?i.parentNode.querySelector(".icon"):null,r=getCookie("MiniCartTotalItems");r&&r>0&&t&&(t.classList.remove("cart-icon-empty"),i.classList.remove("hidden"),i.classList.add("cart-items-number"),r>9999?(i.innerHTML=9999,t.classList.add("cart-icon-full"),i.classList.add("cart-items-number"),i.classList.remove("hidden")):(i.innerHTML=r,t.classList.remove("cart-icon-full")))},e.init(),e.initMiniCartCount(),e}(utilitybarBase||{});</script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_23"); </script> </div>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_24"); </script>  <script data-inline-file-name='digitaldata.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/digitaldata.js */ (function () { "use strict"; /** * Invoking a Function as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. Please try again later.", "MINICART_ERROR_2" :"Please enter a quantity in the range of 1 to 999.", "MINICART_ERROR_3" :"Could not add item(s) to cart.", "MINICART_ERROR_4" :"Could not remove item from cart.", "MINICART_ERROR_5" :"Could not create/restore cart.", "MINICART_ERROR_6" :"Unable to retrieve cart details. Please try again later.", "MINICART_MESSAGE_1" :"Adding item(s) to cart...", "MINICART_MESSAGE_2" :"Removing item(s) from cart...", "MINICART_CART_NAME_LABEL_1" :"Recently added to the", "MINICART_NOTE_1" : "Your total price and product details can be viewed in the cart.", MINICART_SUMMARY : "Cart summary", MINICART_PRICE : "Price", MINICART_PRODUCT : "Product", LIST_PRICE : "Price", YOUR_PRICE : "Your price", WEB_PRICE: "Online offer", PRICE_ENDS: "ends", SIGN_IN: "Sign in", //New mini cart CATALOG_NUMBER: "Catalog number:", CONTACT_US: "Contact us", RFQ: "Request quote", LEARN_WHERE_TO_BUY: "Learn where to buy", CURRENCY: "USD", //End new mini cart "CHANGE_CART" :"Change cart", "VIEW_ALL" :"View All", "ITEM" :"item", "ITEMS" :"items", "CLOSE" :"Close", "SUBTOTAL" :"Subtotal", "TOTAL" :"Total", "MANAGE_CART" :"Manage Cart", "FIELD" :"field", "GLOBAL_ERROR_1" :"Please choose one or both of the options for", "GLOBAL_ERROR_2" :"is not a valid e-mail address.", "GLOBAL_ERROR_3" :"Unsupported character(s) were found in field", "GLOBAL_ERROR_4" :"and will be replaced with plain text equivalents (where available). Please review the changes and try again.", "GLOBAL_ERROR_5" :"Please fill in the", "GLOBAL_ERROR_6" :"Quantities must be whole numbers greater than or equal to zero.", "GLOBAL_ERROR_7" :"is either not a number or a number less than zero, please provide a numerical quantity", "GLOBAL_ERROR_8" :"Reserved character | not allowed. Please remove and try again.", "required" : "One or more required fields are missing", "requireOneOfMany" : "At least one field in the group must be filled out", "password" : "Password does not conform to the password policy", "passwordConfirm" : "Password and Confirm Password do not match", "emailConfirm" : "Email and Confirm Email do not match", "secretConfirm" : "Secret Answer and Confirm Secret Answer do not match", "alphanumeric" : "Value must be alphanumeric", "phone" : "Phone number or Fax number provided were non-numeric values", "email" : "Email address provided is in an invalid format", "date" : "Date is in an invalid format (ex. MM/DD/YYYY)", "expirationDate" : "Expiration date provided is invalid", "currency" : "Currency is in an invalid format", "creditCard" : "Credit card number is invalid", "quantity" : "Quantity must in the range of 1 - 999", "acceptance" : "The terms and conditions must be accepted to continue", "checkboxes" : "At least one item must be selected", "twoOrMorecheckboxes" : "Merging carts requires multiple carts to be selected", "file" : "A file must be selected to upload", "NEW_USER" :"New user", "REGISTER_NOW" :"Register Now", "LOGIN_WIDGET_MESSAGE1" :"View your contract prices and real-time product availability.", "WELCOME" :"Welcome", "MY_ACCOUNT" :"My Account", "FAVORITES" :"Favorites", "SAVED_LISTS" :"Saved Lists", "ORDER_STATUS" :"Order Status", "LOGOUT" :"Logout", "APPROVALS" :"Approvals", "REMOVE" :"Remove", "QUANTITY" :"Qty", "EDIT" :"Edit", "SEARCH_BOX_TEXT" :"",//"Search by catalog number or keyword", "SELECT_LANGUAGE" :"Select a Language", "MY_MESSAGES" :"My Messages", "MESSAGE_ALERTS" :"Message Alerts", "B2B_NEW_WINDOW_ALERT" :"You are about to open a new browser window. \nClicking an external link on our site causes a new window to open. However, your shopping session will remain active in this window.Simply return here to continue shopping. \n Would you like to proceed?", "GREETING" :"", "SCMS_SHIP_TO_LAB" :"Ship To Lab", "SCMS_SHIP_TO_SC" :"Supply Center Order", "SCMS_SHIP_TO_SC_FOR_EU":"Supply Centre Order", "SUBMIT" :"Submit", "SUBMIT_ERROR_VALIDATE_EMAIL":"Sorry - we could not validate your email address. Please try again. ", "SUBMIT_ERROR_SERVER" :"We had an issue handling your request - please try again later.", "RECENT_SEARCHES" :"Recent searches", "inText" :"in", "searchSuggestions" :"Search suggestions", "RECENTLYVIEWED_TITLE" : "Recently Viewed Items", "RECENTLYVIEWED_DELETE" : "Remove", "RECENTLYVIEWED_TODAY" : "Today", "RECENTLYVIEWED_PAGINATE": "{C} of {T}", DF_MONTH_0:"January", DF_MONTH_1:"February", DF_MONTH_2:"March", DF_MONTH_3:"April", DF_MONTH_4:"May", DF_MONTH_5:"June", DF_MONTH_6:"July", DF_MONTH_7:"August", DF_MONTH_8:"September", DF_MONTH_9:"October", DF_MONTH_10:"November", DF_MONTH_11:"December", DF_WEEKDAY_0:"Sun", DF_WEEKDAY_1:"Mon", DF_WEEKDAY_2:"Tue", DF_WEEKDAY_3:"Wed", DF_WEEKDAY_4:"Thu", DF_WEEKDAY_5:"Fri", DF_WEEKDAY_6:"Sat", DF_FORMAT:"{0}, {2} {1}" }; var localizedImage = { "LOGIN_WIDGET_EXPAND":"/shared-static/images/buttons/loginWidgetExpand.gif", "LOGIN_WIDGET_MY_ACCOUNT_EXPAND":"/shared-static/images/buttons/loginWidgetMyAccountExpand.gif", "LOGIN_WIDGET_CONTRACT":"/shared-static/images/buttons/loginWidgetContract.gif", "LOGIN_WIDGET_MY_ACCOUNT_CONTRACT":"/shared-static/images/buttons/loginWidgetMyAccountContract.gif", "LOGOUT_BUTTON":"/shared-static/images/login/useraccount.gif", "CLOSE_SESSION_COOL":"/shared-static/images/login/Close-Session-Cool.JPG", "ICON_CLOSE":"/shared-static/images/login/icon_close.GIF" }; var localizedLink = { "B2B_CHECK_OUT_LINK":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "B2B_MANAGE_CART_LINK":"/en/US/procurement/lt?cmd=OILDataDisplay&ShoppingCartKey=", "B2B_VIEW_ALL_LINK":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "LIGGED_IN_CHECKOUT_LINK":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "LOGGED_IN_MANAGE_CART_LINK":"/en/US/direct/lt?cmd=OILDataDisplay&ShoppingCartKey=", "LOGGED_IN_VIEW_ALL_LINK":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "ANONYMOUS_CHECKOUT_LINK":"/en/US/adirect/lt?cmd=ViewCart&ShoppingCartKey=", "ANONYMOUS_MANAGE_CART_LINK":"/en/US/adirect/lt?cmd=OILDataDisplay&ShoppingCartKey=", "ANONYMOUS_VIEW_ALL_LINK":"/en/US/adirect/lt?cmd=ViewCart&ShoppingCartKey=", "PRODUCT_DETAIL_URL_B2B":"/en/US/procurement/lt?cmd=catProductDetail&productID=", "PRODUCT_DETAIL_URL_ANONYMOUS":"/en/US/adirect/lt?cmd=catProductDetail&productID=", "PRODUCT_DETAIL_URL_LOGGED_IN":"/en/US/direct/lt?cmd=catProductDetail&productID=", "MY_ACCOUNT_LINK_CSR":"/en/US/enterpriseMgr/lt?cmd=HomeDataDisplay", "QUICK_ORDER_ANONYMOUS":"/en/US/adirect/lt?cmd=IVGNQuickOrderLanding", "MY_ACCOUNT_LINK_B2B":"/en/US/procurement/lt?cmd=PartnerSysUserMyAccount", "ORDER_STATUS_LINK_B2B":"/en/US/procurement/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered", "MY_ACCOUNT_LINK":"/en/US/direct/lt?cmd=PartnerSysUserMyAccount", "ORDER_STATUS_LINK":"/en/US/direct/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered", "COMERGENT_CLOSE_SESSION_LINK":"/en/US/procurement/lt?cmd=PunchInOrder&mode=Cancel", "REGISTRATION_URL":"/en/US/adirect/lt?cmd=FullRegistrationData&GroupKey=103&Command=updateExecute&anonymousHomePageMsg=OnlineOrderingPageDisplay", "LIGGED_IN_CHECKOUT_LINK_SCMS":"/en/US/direct/lt?cmd=ViewCart&ShoppingCartKey=", "SCMS_CHECKOUT_SC":"/en/US/procurement/lt?cmd=SetSCMSAddress", "SCMS_CHECKOUT":"/en/US/procurement/lt?cmd=ViewCart&ShoppingCartKey=", "PSCMS_CHECKOUT_SC":"/en/US/procurement/lt?cmd=PSCMSCheckout", "GUEST_USER_AUTH_REDIRECT":"/en/US/procurement/lt?cmd=B2BMasterUserRegistration&operation=identifyUser", "GUEST_USER_AJAX_AUTH":"/en/US/procurement/lt?cmd=B2BMasterUserRegistration&operation=validateNLogin", "GUEST_USER_AJAX_AUTH_UNIQUE_EXPRESS":"/en/US/procurement/lt?cmd=ExpressUniqueUserEmailUpdate", "GUEST_USER_SEARCH_TOOL":"/en/US/direct/lt?cmd=WorkspaceDataDisplay&_Tab=Ordered" }; var localizedMasterUserPopoverSettings = { title:'', content_template: '<div><span class="master-user-popover-close-button">x</span><p class="content_fill">Please enter your email address to use this feature.</p>'+ '<form class="masterUserEmailSubmit form-inline" action="" method="post" onsubmit="return false;">'+ '<div class="auth-error-messaging">'+ '<small class="text-error error-form error-required hide">'+localizedStrings.EMAIL_ERROR_4+'</small>'+ '<small class="text-error error-form error-invalid hide">'+localizedStrings.EMAIL_ERROR_4+'</small>'+ '<small class="text-error error-form error-register hide">'+localizedStrings.SUBMIT_ERROR_SERVER+'</small>'+ '<small class="text-error error-form error-communicate hide">'+localizedStrings.SUBMIT_ERROR_VALIDATE_EMAIL+'</small>'+ '</div>'+ '<span class="control-group">'+ '<input type="text" name="masterUserEmailAddress" class="masterUserEmailAddress input-medium" />'+ '</span> '+ '<input type="button" class="btn btn-primary button primary-button" value="'+localizedStrings.SUBMIT+'" />'+ '<input type="hidden" name="return-url" class="return-url" />'+ '<input type="hidden" name="return-url-is-function-call" class="return-url-is-function-call" />'+ '</form>', content_ordering: '<p class="content_fill content_ordering_fill">Please enter your email address to see order history. Or, you can <a href="#" class="link_search_tool">use the search tool</a> to look for individual orders.</p>', html:true, trigger:'manual', template: '<div class="popover" style="width: 300px; max-width: none;"><div class="arrow"></div><div class="popover-inner"><h3 class="popover-title"></h3><div class="popover-content"><p></p></div></div></div>' }; </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_26"); </script>   <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalHeader:renderEnd"); </script> <div class="full-bg" id="full-bg"></div> <div class="search-bg" id="search-bg"></div> </div> </header>  <script>var useNewJquery = 'PatternLibrary';</script> <link href="/etc/designs/lifetech/clientlibs/base.min.css" rel="stylesheet" rel="preload" as="style" /> <link href="/etc/designs/lifetech/clientlibs/base-responsive.css" rel="stylesheet" rel="preload" as="style" /> <script type="text/javascript" src="/etc/designs/lifetech/clientlibs/base-jquery.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/etc/designs/lifetech/clientlibs/base-bootstrap.min.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script src="/shared-static/scripts/global-variables.js"></script> <script src="/shared-static/scripts/global-functions.js"></script> <script src="/shared-static/scripts/environmenturl.js"></script> <script src="/etc/designs/komodo/clientlibs/s_code.js"></script> <script src="/shared-static/scripts/jquery.ivgnModal.js"></script>  <div class="genomic-product-search genomic-product-search-contents content group container page-PDP"> <div class="contents row-fluid"> <div class="span12">    <script type="text/javascript"> if (typeof window.$m === 'undefined' || !window.$m) { window.$m = {}; } window.$m.productName ='CD45 Monoclonal Antibody (30-F11), PE, eBioscience\u2122'; if (typeof window.$mangular === 'undefined' || !window.$mangular) { window.$mangular = {}; } window.$mangular.productCategory = 'Antibody'; window.$mangular.productType = 'antibody'; window.$mangular.productSubType = 'Antibody'; window.$mangular.antibodyAspireLink = '/us/en/home/products-and-services/aspire-member-program.html?cid=bid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAAntibodyPDP2021'; window.$mangular.ComergentHost = 'www.thermofisher.com' window.$mangular.contryCode = 'sg'; window.$mangular.languageCode = 'en'; window.$mangular.allowShowMoreShowLess = 'false'; window.$mangular.newImageGalleryElisa ='true'; window.$mangular.videoInImageGallery = 'true'; window.$mangular.relatedProducstWidgetV2 ='true'; window.$mangular.brightcoveAccountId = '3663210762001'; window.$mangular.referenceSortByFilterRemoved = 'true'; window.$mangular.techSupportModalEmailFormUrl = 'https://www.thermofisher.com/sg/en/home/technical-resources/contact-us/ext-antibody-technical-support.12-0451-82.html'; window.$mangular.referenceFilterEnabled = 'true'; window.$mangular.galleryFilterEnabled = 'true'; window.$mangular.isB2BUser = 'false'; window.$mangular.isFullSizeImageEnabled = 'true'; window.$mangular.productWebName = 'CD45 Monoclonal Antibody (30-F11), PE, eBioscience\u2122'; window.$mangular.chatBaseApiUrl = 'https://chat-api.thermofisher.com'; window.$mangular.newChatGateWayEnabled = 'false'; window.$mangular.countryCode = 'sg'; window.$mangular.promoAdEnabled = 'true'; </script> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/css/font-common.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/js/angular/dist/pdp/antibody.pdp.dist.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/core/dist/angular/gallery-module/gallery-module.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <style> .fill-color { fill:var(--fill-svg-path); } </style> <symbol id="icon-data-sheet" viewBox="0 0 21 17"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-116.000000, -584.000000)"> <g transform="translate(116.000000, 584.000000)"> <path class="fill-color" d="M0,16.5249711 L5.00100002,16.5249711 L5.00100002,3.30482752 L0,3.30482752 L0,16.5249711 Z M1.66700001,14.8571376 L3.33400002,14.8571376 L3.33400002,4.97182752 L1.66700001,4.97182752 L1.66700001,14.8571376 Z" ></path> <path class="fill-color" d="M7.50150003,16.5249711 L12.5025001,16.5249711 L12.5025001,8.26248554 L7.50150003,8.26248554 L7.50150003,16.5249711 Z M9.16850004,14.8571376 L10.8355,14.8571376 L10.8355,9.92865205 L9.16850004,9.92865205 L9.16850004,14.8571376 Z" ></path> <path class="fill-color" d="M15.0030001,16.5249711 L20.0040001,16.5249711 L20.0040001,0 L15.0030001,0 L15.0030001,16.5249711 Z M16.6700001,14.8579711 L18.3370001,14.8579711 L18.3370001,1.66700001 L16.6700001,1.66700001 L16.6700001,14.8579711 Z" ></path> </g> </g> </g> </symbol> <symbol id="icon-protocols" viewBox="0 0 22 20"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-1.000000, -2.000000)"> <path class="fill-color" d="M17.8,2.5l3.8,3.8c0.5,0.5,0.5,1.4,0,1.9l-5.4,5.4c-0.5,0.5-1.4,0.5-1.9,0L13,12.3l-1.1,1.1 l1.2,1.2c0.5,0.5,0.5,1.4,0,1.9l-5.4,5.4c-0.5,0.5-1.4,0.5-1.9,0l-3.8-3.8c-0.5-0.5-0.5-1.4,0-1.9l5.4-5.4c0.5-0.5,1.4-0.5,1.9,0 l1.1,1.1l1.1-1.1l-1.1-1.1c-0.5-0.5-0.5-1.4,0-1.9l5.4-5.4C16.4,1.9,17.3,1.9,17.8,2.5z M8.4,12.8L4,17.2l2.8,2.8l4.5-4.5 l-0.8-0.8L9.3,16l-1.4-1.4L9,13.4L8.4,12.8z M16.8,4.3l-4.5,4.5L13,9.4l1.1-1.1l1.4,1.4l-1.1,1.1l0.8,0.8l4.5-4.5L16.8,4.3z" /> </g> </g> </symbol> <symbol id="icon-create-citation" viewBox="0 0 23 21"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-260.000000, -582.000000)"> <path class="fill-color" d="M272.324583,582 L262.476833,593.568087 L261.673833,598.68327 L260,600.221115 L260,602 L282,602 L282,600.221115 L262.672083,600.221115 L262.858167,600.047674 L268.246333,598.191408 L278.095917,586.624211 L272.324583,582 Z M264.041583,594.345459 L272.57025,584.505559 L275.51275,586.862581 L266.983167,596.701592 L264.041583,594.345459 Z M263.96,596.402739 L265.097583,597.314418 L263.71525,597.813395 L263.96,596.402739 Z" id="Page-1" transform="translate(271.000000, 592.000000) rotate(-1.000000) translate(-271.000000, -592.000000) "></path> </g> </g> </symbol> <symbol id="icon-qna" viewBox="0 0 19 22"> <path class="fill-color" d="M8,11.34h2v2H8ZM6,7.21a3.06,3.06,0,0,1,.23-1.15,2.56,2.56,0,0,1,1.52-1.5A3.14,3.14,0,0,1,9,4.34a4,4,0,0,1,1.45.23,2.87,2.87,0,0,1,.93.56,1.94,1.94,0,0,1,.51.73,2,2,0,0,1,.15.72,2.42,2.42,0,0,1-.15.92,2.18,2.18,0,0,1-.38.61,2.59,2.59,0,0,1-.5.44l-.52.36a2.09,2.09,0,0,0-.43.41,1.09,1.09,0,0,0-.24.58v.44H8.13V9.82A2.46,2.46,0,0,1,8.34,9a2.36,2.36,0,0,1,.38-.57A2.88,2.88,0,0,1,9.18,8c.17-.12.32-.24.45-.35A2,2,0,0,0,10,7.27a1.07,1.07,0,0,0,.12-.53A1.05,1.05,0,0,0,9.81,6a1.07,1.07,0,0,0-.76-.25,1.26,1.26,0,0,0-.57.12,1,1,0,0,0-.39.33,1.2,1.2,0,0,0-.22.47,2.21,2.21,0,0,0-.08.59Z"/> <g> <path class="fill-color" d="M4.1,22V16.55H0V0H19V16.55H11.43ZM2,14.55H6.1V18l4.67-3.46H17V2H2Z"/> </g> </symbol> <symbol id="icon-tech-support" viewBox="0 0 25 20"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-424.000000, -582.000000)" fill-rule="nonzero"> <g transform="translate(424.000000, 582.000000)"> <g> <path class="fill-color" d="M19.8028437,4.49241085 L20.6158492,4.49241085 L23,4.49241085 L23,2 L16,2 L16,4.49241085 L19.0144231,4.49241085 L19.0144231,5.26028879 L19.8028437,4.49241085 Z M20.6158492,6.49241085 L17.0144231,10 L17.0144231,6.49241085 L14,6.49241085 L14,0 L25,0 L25,6.49241085 L20.6158492,6.49241085 Z" id="Combined-Shape"></path> <path class="fill-color" d="M8.5,14 C6.01471863,14 4,11.9852814 4,9.5 C4,7.01471863 6.01471863,5 8.5,5 C10.9852814,5 13,7.01471863 13,9.5 C13,11.9852814 10.9852814,14 8.5,14 Z M8.5,12 C9.88071187,12 11,10.8807119 11,9.5 C11,8.11928813 9.88071187,7 8.5,7 C7.11928813,7 6,8.11928813 6,9.5 C6,10.8807119 7.11928813,12 8.5,12 Z" id="Oval-2"></path> <path class="fill-color" d="M0.613568084,20 L1.0511019,18.6844174 C2.50568865,14.3107461 5.04750487,12 8.5999882,12 C12.1640717,12 14.6451209,14.3259794 15.9580242,18.7133126 L16.3430636,20 L0.613568084,20 Z M13.5943938,18 C12.4931866,15.2747206 10.8472364,14 8.5999882,14 C6.34912378,14 4.64995118,15.278916 3.45203497,18 L13.5943938,18 Z" id="Path-7"></path> </g> </g> </g> </g> </symbol> <symbol id="icon-published-figures" viewBox="0 0 14 17"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-119.000000, -363.000000)" fill="#222222"> <path d="M131.133333,378.111122 L121.8,378.111122 C121.338,378.111122 120.969333,377.763568 120.896533,377.315904 L129.442133,377.315904 L130.375467,377.315904 L130.375467,376.371465 L130.375467,366.678685 L131.133333,366.678685 L131.133333,378.111122 Z M121.8,364.888973 L128.507867,364.888973 L128.507867,375.427025 L120.866667,375.427025 L120.866667,365.833412 C120.866667,365.312082 121.285733,364.888973 121.8,364.888973 Z M130.375467,364.789807 L130.375467,363.944534 L130.375467,363.000094 L129.442133,363.000094 L121.8,363.000094 C120.320667,363.000094 119.122267,364.163644 119.0196,365.63508 C119.015867,365.66908 119,365.698357 119,365.734246 L119,365.833412 L119,376.371465 L119,377.166682 L119,377.315904 L119.014933,377.315904 C119.093333,378.810007 120.303867,380 121.8,380 L133,380 L133,364.789807 L130.375467,364.789807 Z" id="Page-1"></path> </g> </g> </symbol> <symbol id="icon-references" viewBox="0 0 13 19"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-375.000000, -465.000000)" fill="#333333" fill-rule="nonzero"> <path d="M386,466.999459 C385.999749,466.999679 383.000669,466.999859 377.00276,467 C377.001684,467 377.000764,471.346542 377,480.039626 L381.5,476.720461 L386,480.039626 L386,466.999459 Z M375,466.997422 C375,465.894276 375.893543,465 377.00276,465 L385.99724,465 C387.103334,465 388,465.890925 388,466.997422 L388,484 L381.5,479.205651 L375,484 L375,466.997422 Z" id="Rectangle-11"></path> </g> </g> </symbol> <symbol id="icon-performance-guarantee" viewBox="0 0 17 20"> <defs> <style>.cls-1{fill:#1e8ae7;}.cls-2{fill:#fff;}</style> </defs> <polygon class="cls-1" points="0 0 0 15.63 8.55 20 17 15.63 17 0 0 0"/> <g> <g> <g> <polygon class="cls-2" points="7.38 12.66 3.34 9.07 4.66 7.58 7.38 9.98 12.34 5.58 13.66 7.07 7.38 12.66"/> </g> </g> </g> </symbol> <symbol id="icon-advanced-verification" viewBox="0 0 14 14"> <g stroke="none" stroke-width="1" fill="none" fill-rule="evenodd"> <g transform="translate(-143.000000, -531.000000)" fill="#E71316"> <g transform="translate(135.000000, 526.000000)"> <g transform="translate(8.000000, 5.000000)"> <g id="advanced-verification-icon"> <polygon id="Path-8" fill-rule="nonzero" points="9.82562882 4.6077322 10.8059501 5.70805727 6.18058487 9.82897051 3.19404987 7.16815328 4.17437118 6.0678282 6.18058487 7.85524002"></polygon> <path d="M7,12.5263158 C10.0520999,12.5263158 12.5263158,10.0520999 12.5263158,7 C12.5263158,3.94790007 10.0520999,1.47368421 7,1.47368421 C3.94790007,1.47368421 1.47368421,3.94790007 1.47368421,7 C1.47368421,10.0520999 3.94790007,12.5263158 7,12.5263158 Z M7,14 C3.13400675,14 0,10.8659932 0,7 C0,3.13400675 3.13400675,0 7,0 C10.8659932,0 14,3.13400675 14,7 C14,10.8659932 10.8659932,14 7,14 Z" id="Oval-3-Copy" fill-rule="nonzero"></path> </g> </g> </g> </g> </g> </symbol> <symbol id="icon-select" viewBox="0 0 32 32"> <path d="M16 22.976l-15.68-13.952h31.36z"></path> </symbol> <symbol id="icon-technical-guide-and-protocol" viewBox="0 0 24 24"> <path class="fill-color" d="M13.9,1.1c0.6,0,1.2,0.3,1.4,0.9l0.6,1.1H20v19.6H3.7V3.1h4.1l0.6-1.1 c0.3-0.5,0.8-0.9,1.4-0.9H13.9z M6.9,5.1l-1.2,0v15.6H18V5.1l-1.2,0c0.1,0.9-0.6,1.7-1.6,1.7H8.5C7.5,6.8,6.8,6,6.9,5.1z M14.8,13.3v2H7.9v-2H14.8z M15.8,10v2H7.9v-2H15.8z M13.7,3.1h-3.6L9.2,4.8h5.3L13.7,3.1z"/> </symbol> <symbol id="icon-sale-tag" viewBox="0 0 17 17"> <path d="M6.85,1H1V6.85L10.17,16,16,10.17ZM4.69,4.69a.88.88,0,1,1,0-1.24A.86.86,0,0,1,4.69,4.69Z"/> </symbol> <symbol id="tooltip-info-icon" viewBox="0 0 16 16" fill="none"> <path d="M8 3C10.76 3 13 5.24 13 8C13 10.76 10.76 13 8 13C5.24 13 3 10.76 3 8C3 5.24 5.24 3 8 3ZM8 1C4.13 1 1 4.13 1 8C1 11.87 4.13 15 8 15C11.87 15 15 11.87 15 8C15 4.13 11.87 1 8 1Z" fill="#0071D0"/> <path d="M7 7V12H9V7H7Z" fill="#0071D0"/> <path d="M7 4V6H9V4H7Z" fill="#0071D0"/> </symbol> <symbol id="tooltip-icon-new" width="16" height="16" viewBox="0 0 16 16" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M8 3C10.76 3 13 5.24 13 8C13 10.76 10.76 13 8 13C5.24 13 3 10.76 3 8C3 5.24 5.24 3 8 3ZM8 1C4.13 1 1 4.13 1 8C1 11.87 4.13 15 8 15C11.87 15 15 11.87 15 8C15 4.13 11.87 1 8 1Z" fill="#70707A"></path> <path d="M7 7V12H9V7H7Z" fill="#70707A"></path> <path d="M7 4V6H9V4H7Z" fill="#70707A"></path> </symbol> <symbol id="supply-center-icon" viewBox="0 0 14 14" fill="none"> <path d="M13.6352 4.98228H12.4043C12.2237 4.98228 12.0763 4.83405 12.0763 4.65247C12.0763 4.47089 12.2237 4.32267 12.4043 4.32267H13.8894C13.9042 4.32267 13.9189 4.32267 13.9337 4.32637C13.9374 4.32637 13.9374 4.32637 13.941 4.32637C13.9558 4.33008 13.9668 4.33008 13.9816 4.33378C13.9926 4.27079 14 4.20779 14 4.14479V3.70752H12.1021C11.9216 3.70752 11.7742 3.55929 11.7742 3.37771C11.7742 3.19613 11.9216 3.04791 12.1021 3.04791H14V2.43276H11.7999C11.6194 2.43276 11.472 2.28453 11.472 2.10295C11.472 1.92137 11.6194 1.77315 11.7999 1.77315H14V1.25805C14 0.628086 13.4914 0.116699 12.865 0.116699H9.98684C9.36036 0.116699 8.8518 0.628086 8.8518 1.25805V4.1522C8.8518 4.78217 9.36036 5.29356 9.98684 5.29356H12.865C13.1635 5.28985 13.4325 5.17127 13.6352 4.98228ZM2.1374 9.58476C0.958147 9.58476 0 10.5445 0 11.7341C0 12.9236 0.958147 13.8834 2.1374 13.8834C3.31666 13.8834 4.27481 12.9236 4.27481 11.7341C4.27481 10.5445 3.32035 9.58476 2.1374 9.58476ZM11.4351 9.58476C10.2522 9.58476 9.29402 10.5445 9.29402 11.7341C9.29402 12.9236 10.2522 13.8834 11.4351 13.8834C12.6181 13.8834 13.5762 12.9236 13.5762 11.7341C13.5762 10.5445 12.6181 9.58476 11.4351 9.58476Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M3.96989 9.2373L2.16784 11.483L1.70897 11.1106L3.51102 8.86497L3.96989 9.2373Z" fill="#E71316"/> <path d="M1.60305 8.52493C3.41616 8.19883 5.20347 9.39947 5.31772 11.5488C5.3214 11.6488 5.40616 11.7304 5.50566 11.7304H8.04475C8.15162 11.7304 8.23638 11.6414 8.23638 11.534C8.19953 10.3889 8.83706 7.94684 13.1008 7.75044C13.1708 7.74673 13.1966 7.65409 13.134 7.61703C8.59384 4.85629 6.51908 7.4688 6.46012 7.26128C6.15794 6.2311 3.46775 5.90129 1.69887 7.56886C1.63991 7.56886 1.61779 7.76896 1.57357 8.49899C1.57357 8.51752 1.58831 8.52863 1.60305 8.52493Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M8.04335 6.19454C9.22408 5.88996 10.9582 5.94786 13.2854 7.36267C13.6173 7.56116 13.4544 8.02859 13.1163 8.04648L13.1153 8.04654L13.1143 8.04658C11.0382 8.14221 9.89727 8.78067 9.27624 9.48338C8.65091 10.1909 8.51438 11.0068 8.53104 11.5244L8.53119 11.5292V11.534C8.53119 11.7977 8.3217 12.0268 8.04475 12.0268H5.50566C5.24976 12.0268 5.03437 11.8219 5.02322 11.5628C4.91822 9.60551 3.3074 8.52267 1.66058 8.81575C1.44688 8.86034 1.27876 8.68563 1.27876 8.49899V8.48997L1.2793 8.48096C1.30123 8.11892 1.31835 7.87521 1.33838 7.72161C1.3479 7.64863 1.36074 7.57251 1.38401 7.50902C1.39546 7.47776 1.41772 7.42574 1.46177 7.37776C1.48144 7.35635 1.5054 7.336 1.53324 7.319C2.47317 6.45193 3.64586 6.10402 4.63038 6.10696C5.12861 6.10845 5.59219 6.19975 5.96108 6.3711C6.21127 6.48732 6.43559 6.64957 6.5867 6.86018C6.63313 6.82917 6.68372 6.79591 6.73271 6.76502C7.02301 6.58198 7.45814 6.3455 8.04335 6.19454ZM6.17724 7.34478C6.13481 7.20068 5.99437 7.03969 5.71381 6.90936C5.43802 6.78125 5.06183 6.70116 4.62863 6.69987C3.77278 6.69732 2.74721 7.00218 1.92874 7.75877C1.927 7.76968 1.92507 7.78289 1.923 7.79871C1.91194 7.88353 1.90121 8.00831 1.88882 8.18848C3.71762 8.03347 5.44218 9.28953 5.6057 11.4339H7.94013C7.94191 10.8059 8.12772 9.89038 8.8355 9.08952C9.50117 8.3363 10.5991 7.7177 12.3509 7.51331C10.467 6.52491 9.09774 6.53466 8.18987 6.76886C7.6815 6.89999 7.30313 7.10519 7.04595 7.26735C6.95868 7.32237 6.89955 7.36272 6.84528 7.39974C6.80942 7.42421 6.77567 7.44723 6.73734 7.47208C6.70477 7.4932 6.65044 7.52796 6.5946 7.54814C6.5711 7.55663 6.49901 7.5815 6.4108 7.56282C6.35949 7.55195 6.30402 7.52647 6.25706 7.47976C6.21225 7.4352 6.18898 7.38508 6.17724 7.34478ZM1.55587 8.23226C1.55319 8.2327 1.55051 8.23318 1.54782 8.2337L1.55115 8.2331C1.55272 8.23282 1.55429 8.23254 1.55587 8.23226Z" fill="#E71316"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M4.49592 4.76364C4.4496 4.47087 4.44944 4.4709 4.44927 4.47092L4.44887 4.47099L4.44785 4.47115L4.44497 4.47163C4.44268 4.47202 4.43965 4.47254 4.4359 4.4732C4.42841 4.47453 4.41806 4.47644 4.40503 4.47899C4.37898 4.48408 4.3422 4.49178 4.29627 4.50266C4.2045 4.52439 4.07568 4.55892 3.92252 4.611C3.61719 4.71483 3.20952 4.89027 2.80491 5.17732C1.98407 5.75966 1.19256 6.79295 1.2754 8.54641C1.28313 8.70995 1.42124 8.83623 1.58388 8.82846C1.74652 8.82069 1.8721 8.68181 1.86437 8.51827C1.79244 6.99589 2.46395 6.14483 3.14482 5.66179C3.49106 5.41615 3.84392 5.26363 4.1114 5.17267C4.24465 5.12736 4.35531 5.0978 4.43142 5.07978C4.46942 5.07078 4.49869 5.06469 4.51769 5.06097C4.52719 5.05911 4.53411 5.05785 4.53827 5.05711C4.54035 5.05674 4.54174 5.05651 4.54241 5.05639C4.5426 5.05636 4.54273 5.05634 4.5428 5.05633C4.7033 5.03034 4.81263 4.87857 4.78707 4.71707C4.76149 4.55537 4.6104 4.44515 4.4496 4.47087L4.49592 4.76364Z" fill="#E71316"/> </symbol> <symbol id="external-link" viewBox="0 0 14 14" fill="none"> <path d="M10 10V12H2V4H4V2H0V14H12V10H10Z" fill="#0071D0"/> <path fill-rule="evenodd" clip-rule="evenodd" d="M7.00002 0V2H10.59L4.02002 8.57L5.44002 9.98L12 3.41V7H14V0H7.00002Z" fill="#0071D0"/> </symbol> </svg> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <symbol id="filters-icon-caret-down" viewBox="0 0 32 32"> <path d="M16 22.976l-15.68-13.952h31.36z"/> </symbol> <symbol id="filters-icon-close" viewBox="0 0 10 10"> <line x1="1" y1="1" x2="9" y2="9"/> <line x1="1" y1="9" x2="9" y2="1"/> </symbol> <symbol id="filters-icon-caret-right" viewBox="0 0 32 32"> <path d="m16,22.976l-15.68,-13.952l31.36,0l-15.68,13.952z" transform="rotate(-90 16,16) "/> </symbol> <symbol id="filters-icon-back" viewBox="0 0 20 20"> <g stroke-width="2"> <line x1="2" y1="10" x2="9" y2="3"/> <line x1="1" y1="10" x2="18" y2="10"/> <line x1="2" y1="10" x2="9" y2="17"/> </g> </symbol> </svg> <div class="antibody-new-pdp"> <div class="magellan-grid pdp non-touch"> <div class="pdp-modals"> <div id="benchsciDisclaimerModal" class="modal fade benchsciDisclaimer-Modal" role="dialog" aria-labelledby="benchsci-DisclaimerModal-title">  <div class="modal-content" role="document"> <div class="modal-header-disclaimer"> <h2 class="pdp-sub-heading modal-title disclaimer-modal-title" id="benchsci-DisclaimerModal-title">Disclaimer</h2> <img class="disclaimer-close-cross" data-toggle="modal" data-target="#benchsciDisclaimerModal" src="/order/genome-database/assets/img/x_close.svg"/> </div> <div class="modal-body"> <p> Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented. </p> </div> </div> </div> </div> <div class="pdp-components"> <div id="pdp-components" ng-controller="pdpMainController as $ctrl">  <div block-ui="main" class="block-ui-main"></div> <div class="hero hero-loading-height" ng-class="{'is-loaded':$ctrl.isLoaded, 'with-banner': 'false' == 'true'}"> <div class="container"> <div class="hero-content"> <div class="brand-breadcrumb to-hide-on-mobile row"> <div class="large-span-12 medium-span-12 target_page_breadcrumbs"> <div class="breadcrumb breadcrumb-hide-restricted-only"> <ul class="breadcrumb breadcrumb-hide-restricted-only hero-breadcrumbs"> <li class="active"> <a href="/us/en/home/life-science/antibodies/primary-antibodies.html" target="_self"> Primary Antibodies </a> <span class="divider">&rsaquo;</span> </li> <li class="active"> <a href="/antibody/primary/target/cd45" target="_self" class="targetLink"> CD45 Antibodies</a> </li> </ul> </div> </div> </div> <svg xmlns="http://www.w3.org/2000/svg" display="none"> <symbol id="close-drawer-icon" viewBox="0 0 22.74 22.74"> <line x1="1.67" y1="1.67" x2="21.33" y2="21.33" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> <line x1="21.07" y1="1.41" x2="1.41" y2="21.07" style="fill:none;stroke:#555759;stroke-linecap:square;stroke-width:2px"/> </symbol> <symbol id="info-icon" viewBox="0 0 32 32"> <path fill="#1e8ae7" d="M16 10.688c-1.152 0-2.048-0.896-2.048-2.048s0.896-2.048 2.048-2.048c1.152 0 2.048 0.896 2.048 2.048 0 1.088-0.96 2.048-2.048 2.048zM17.792 22.976c0 0.768-0.064 1.152-0.256 1.536-0.256 0.576-0.832 0.896-1.6 0.896-0.704 0-1.28-0.32-1.6-0.896-0.192-0.384-0.256-0.768-0.256-1.536v-8.256c0-0.768 0.064-1.152 0.256-1.536 0.256-0.576 0.832-0.896 1.6-0.896 0.704 0 1.28 0.32 1.6 0.896 0.192 0.384 0.256 0.768 0.256 1.536v8.256zM16 0.64c-8.512 0-15.36 6.848-15.36 15.36s6.848 15.36 15.36 15.36c8.512 0 15.36-6.848 15.36-15.36s-6.848-15.36-15.36-15.36z"></path> </symbol> <symbol id="info-orange-icon" viewBox="0 0 32 32"> <path fill="#ed7700" d="M16 10.688c-1.152 0-2.048-0.896-2.048-2.048s0.896-2.048 2.048-2.048c1.152 0 2.048 0.896 2.048 2.048 0 1.088-0.96 2.048-2.048 2.048zM17.792 22.976c0 0.768-0.064 1.152-0.256 1.536-0.256 0.576-0.832 0.896-1.6 0.896-0.704 0-1.28-0.32-1.6-0.896-0.192-0.384-0.256-0.768-0.256-1.536v-8.256c0-0.768 0.064-1.152 0.256-1.536 0.256-0.576 0.832-0.896 1.6-0.896 0.704 0 1.28 0.32 1.6 0.896 0.192 0.384 0.256 0.768 0.256 1.536v8.256zM16 0.64c-8.512 0-15.36 6.848-15.36 15.36s6.848 15.36 15.36 15.36c8.512 0 15.36-6.848 15.36-15.36s-6.848-15.36-15.36-15.36z"></path> </symbol> </svg> <div class="brand-info"> <p class="brand-name" itemprop="brand">Invitrogen</p> </div> <h1 class="product-name">CD45 Monoclonal Antibody (30-F11), PE, eBioscience™</h1> <div class="details-hero" ng-click="$ctrl.toggleImages('ADVANCED_VERIFICATION')"> <a class="link adv-verification-link animated-scroll" href="/sg/en/home/life-science/antibodies/invitrogen-antibody-validation.html"> <svg class="svg-icon advanced-verification-icon"> <use href="#icon-advanced-verification"></use> </svg> Advanced Verification </a> <p class="adv-verification-detail" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationSmLtr(event, this)"> This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. </p> </div> <div class="details-hero" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationPublishedFigures(event, this)"> <a class="link published-link animated-scroll " href="#image-gallery" onclick="window.THERMO_FISHER.pdp.inp.publishedFiguresHero(event, this)"> <svg class="svg-icon published-figures-icon"> <use href="#icon-published-figures"></use> </svg> 97 Published Figures </a> </div> <div class="details-hero"> <a class="link references-link animated-scroll " href="#references-component-id" onclick="window.THERMO_FISHER.pdp.inp.referencesHero(event, this)"> <svg class="svg-icon references-icon"> <use href="#icon-references"></use> </svg> 313 References </a> </div> <div class="details-hero"> <a class="btn hero-btn hero-view-other" href="/antibody/primary/target/cd45"> View all (361) CD45 antibodies </a> </div> </div> <div class="links-ab to-show-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=12-0451-82&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.12-0451-82.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div class="cmrc-card-cnt" id="antibody_primary"> <div class="price-card-alignmnet" tf-product-order> <aside class="sidecard"> <div ng-switch on="$productOrderCtrl.isMultiPack()"> <div ng-switch-when="true"> <div ng-include="$productOrderCtrl.getTemplatePath()+'product-order-multipack.template.html'"></div> </div> <div ng-switch-default> <div ng-include="$productOrderCtrl.getTemplatePath()+'product-order-singlepack.template.html'"></div> </div> </div> </aside> </div> </div> </div> <div id="createCitationModal" class="modal fade citation-modal" role="dialog" aria-labelledby="createCitationModal-title">  <div class="modal-content" role="document"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal">×</button> <h4 class="modal-title" id="createCitationModal-title">Cite CD45 Monoclonal Antibody (30-F11), PE, eBioscience™</h4> </div> <div class="modal-body"> <textarea id="citationTextArea" rows="5">The following product was used in this experiment: CD45 Monoclonal Antibody (30-F11), PE, eBioscience™ from Thermo Fisher Scientific, catalog # 12-0451-82, RRID AB_465668.</textarea> </div> <div class="modal-footer">  <button type="button" class="well-red btn btn-danger pull-left" data-dismiss="modal" onclick="copyToClipboard();" > Click to Copy </button>  </div> </div> </div> <script type="application/ld+json"> { "@context": "https://schema.org/", "@type": "BreadcrumbList", "itemListElement": [{ "@type": "ListItem", "position": 1, "name": "Home", "item":"https://www.thermofisher.com" },{ "@type": "ListItem", "position": 2, "name": "Antibodies", "item": "https://www.thermofisher.com/us/en/home/life-science/antibodies.html" },{ "@type": "ListItem", "position": 3, "name": "CD45", "item": "https://www.thermofisher.com/antibody/primary/target/cd45" }] } </script> </div> <div class="links-ab to-hide-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=12-0451-82&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.12-0451-82.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div id="image-gallery" class="scrollClass image-gallery-loading-height" ng-class="{'is-loaded':$ctrl.isLoaded}"> <div id="tabName" tab-name-value="changeTabValue"></div> <div id="originalProductLink" product-link-value="originalProductLinkValue"></div> <div class="gal-cntr container" tfs-media-gallery sku="'12-0451-82'" media-items="{'Antibody Testing Data':[{'sku':'12-0451-82','imageId':'710847','imageUrl':'https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time\u003d20240507','sortOrder':'1','description':'C57BL/6 mouse bone marrow cells were stained with TER-119 Monoclonal Antibody, FITC (Product # 11-5921-82) and 0.015 µg of Rat IgG2b kappa Isotype Control, PE (Product # 12-4031-83) (left) or 0.015 µg of CD45 Monoclonal Antibody, PE (right). Total viable cells were used for analysis.','shortDescription':'C57BL/6 mouse bone marrow cells were stained with TER-119 Monoclonal Antibody, FITC (Product # 11-5921-82) and 0.015 µg of Rat IgG2b kappa Isotype Control, PE (Product # 12-4031-83) (left) or 0.015 µg of CD45 Monoclonal Antibody, PE (right). Total viable cells were used for analysis.','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','appName':'Flow Cytometry','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg','benchSciPubmedId':'0'}],'Published Figures':[{'sku':'12-0451-82','imageId':'1018375','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24425_ijms-23-08238-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24425_ijms-23-08238-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24425_ijms-23-08238-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24425_ijms-23-08238-g002.jpg?time\u003d20240507','sortOrder':'3','description':'Clonal assay of MSCs after co-culture with HSCs. ( A ) Representative flow cytometric profiles of MSCs (upper, CD31 - , CD45 - , Ter119 - , Sca-1 + , and PDGFR-alpha + cells) and HSCs (bottom, c-Kit + , Lin - , and Sca-1 + cells). Microscopic views of MSCs (upper) and HSCs (bottom). ( B , C ) Cell proliferation of MSCs ( B ) and HSCs ( C ) 2, 4, 6, and 8 days after co-culture ( n \u003d 6). * p \u003c 0.05 and ** p \u003c 0.01 between direct and indirect co-culture. ( D ) MSC and HSC population in whole mesenchymal and hematopoietic cells. MSCs were sorted on day -1, and we waited until they attached to the bottom of the dish on day 0. After co-culture of MSCs and HSCs for 3, 5, and 7 days, cells were collected, sorted based on EGFP expression, and both cell types were detected using stem cell markers by flow cytometry. ( E ) Real-time PCR analysis of mesenchymal lineage marker expression in MSCs following a 3-week treatment with mesenchymal differentiation media after co-culture with HSCs ( n \u003d 5). * p \u003c 0.05 vs. MSCs (-HSCs).','shortDescription':'Clonal assay of MSCs after co-culture with HSCs. ( A ) Representative flow cytometric profiles of MSCs (upper, CD31 - , CD45 - , Ter119 - , Sca-1 + , and PDGFR-alpha + cells) and HSCs (bottom, c-Kit + , Lin - , and Sca-1 + cells). Microscopic views of MSCs (upper) and HSCs (bottom). ( B , C ) Cell proliferation of MSCs ( B ) and HSCs ( C ) 2, 4, 6, and 8 days after co-culture ( n \u003d 6). * p \u003c 0.05 and ** p \u003c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 26, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24425_ijms-23-08238-g002.jpg','benchSciPubmedId':'35897814'},{'sku':'12-0451-82','imageId':'1111341','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'4','description':'Morphology and characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) and hUCMSC exosomes. a Appearance of MSC fibroblast sample, as shown based on an optical microscope image (x40). b The surface markers of hUCMSCs were analyzed via flow cytometry. hUCMSCs tested positive for CD73, CD105, and CD90, but were negative for CD34, CD14, CD19, CD45, and HLA-DR. c MSCs had the ability to differentiate into adipocytes (x40). d MSCs also had the ability to differentiate into chondrocytes (x40). e MSCs had the ability to differentiate into osteoblasts (x40). f Exosome morphology observed via transmission electron microscopy. g The particle size distribution of exosomes measured using NANOSIGHT software. h Western blot analyses of the exosome surface markers (CD9, CD81, and CD63)','shortDescription':'Morphology and characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) and hUCMSC exosomes. a Appearance of MSC fibroblast sample, as shown based on an optical microscope image (x40). b The surface markers of hUCMSCs were analyzed via flow cytometry. hUCMSCs tested positive for CD73, CD105, and CD90, but were negative for CD34, CD14, CD19, CD45, and HLA-DR. c MSCs had the ability to differe... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 18, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of nanobiotechnology','journalText':'Journal of nanobiotechnology 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29165_12951_2023_2145_Fig1_HTML.jpg','benchSciPubmedId':'37848990'},{'sku':'12-0451-82','imageId':'1139189','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time\u003d20240507','sortOrder':'5','description':'3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n \u003d 5 animals per group in (C); data were pooled from two independent experiments. D ELISA analysis of the concentration of TNF-alpha, IFN-gamma, and CRP in the peripheral blood of mice after different treatments ( n \u003d 3-5 animals per group). E ELISPOT analysis of IFN-gamma spot-forming. F The corresponding quantification numbers of spots in (E). n \u003d 5 animals per group; data were pooled from two independent experiments. Data information: Data in (C), (D), and (F) are presented as mean +- SD. Statistical significance was calculated by one-way ANOVA with Tukey\u0027s multiple comparison test in (C, D) and two-tailed Student\u0027s t -test in (F). * P \u003c 0.05, ** P \u003c 0.01 and *** P \u003c 0.001. ns means no significant difference. Source data are available online for this figure.','shortDescription':'3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 11, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO molecular medicine','journalText':'EMBO molecular medicine 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg','benchSciPubmedId':'37552209'},{'sku':'12-0451-82','imageId':'1020387','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24743_fphar-13-1095757-g002.jpg?time\u003d20240507','sortOrder':'6','description':'FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means the lumen side of the vascular wall, and A means the adventitia side of the vascular wall. (D,E) Immunofluorescence analysis for vimentin (white) (D) and CD45 (purple) (E) and overlays with DAPI-labeled nuclei (blue) showing fibroblasts and immune cells in the human aorta (scale bars: 100 mum). (F) Immunostaining for calponin (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the mouse aortic media (scale bars: 100 mum). (G) Immunostaining for vimentin (white) and DAPI overlay in the thoracic and abdominal aorta form mice subjected to 4 weeks of Ang II induction (scale bars: 500 mum). (H) Immunostaining for CD45 (red), CD68 (green), and overlays with DAPI-labeled nuclei (blue) showing macrophages in the mouse aorta (scale bars: 100 mum). (I) Flow cytometry of the proportion of macrophages (F4/80 + CD11B + ), monocytes (LY6C + CD11B + ), and T cells (CD3 + ) in CD45 + immune cells among three groups (n \u003d 3-4, per group).','shortDescription':'FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means th... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 2, 2023, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in pharmacology','journalText':'Frontiers in pharmacology 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24743_fphar-13-1095757-g002.jpg','benchSciPubmedId':'36703732'},{'sku':'12-0451-82','imageId':'1020330','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24778_jci-132-160097-g179.jpg?time\u003d20240507','sortOrder':'7','description':'Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n \u003d 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-5/group. ( D ) Immunofluorescence of the pancreas. Scale bars: 20 mum. ( A - D ) Data and images are representative of at least 3 independent experiments. All data are expressed as mean +- SEM. *** P \u003c 0.001, ** P \u003c 0.01, * P \u003c 0.05 by 2-way ANOVA with Bonferroni\u0026apos;s post hoc. ( E ) Top 15 most-relevant, upregulated (red) and downregulated (blue) genes in the islet from WT versus KO mice on a HFD. Mean values from n \u003d 4-5/group. ( F ) Volcano plot of the fold change ( x axis) versus adjusted (adj.) P value ( y axis) of the transcriptomes between the islets from WT and KO mice on a HFD. Genes highlighted in red or blue are based on the thresholds of log 2 fold change \u003e 1 and adj. P \u003c 0.05. ( G ) Pathways of the islets from WT versus KO mice on a HFD that were either activated (red) or repressed (blue) by lack of GPR92. Normalized enrichment score (NES) is represented in log 10 ( P ).','shortDescription':'Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n \u003d 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n \u003d 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24778_jci-132-160097-g179.jpg','benchSciPubmedId':'36066975'},{'sku':'12-0451-82','imageId':'1020368','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g201.jpg?time\u003d20240507','sortOrder':'8','description':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) and prednisolone-treated (PRD-treated) 4.5-week-old mdx diaphragms compared with vehicle (VEH) controls. n \u003d 6 replicates per group pooled from 2 mice each were used. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ), or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P \u003c\u003d 0.05.','shortDescription':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 10, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24779_jciinsight-7-159875-g201.jpg','benchSciPubmedId':'36040807'},{'sku':'12-0451-82','imageId':'1020349','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g200.jpg?time\u003d20240507','sortOrder':'9','description':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) ( n \u003d 13) and prednisolone-treated (PRD-treated) ( n \u003d 13) 4.5-week-old mdx quadriceps compared with vehicle (VEH) ( n \u003d 12) controls. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ) or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P \u003c\u003d 0.05.','shortDescription':'Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 10, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24779_jciinsight-7-159875-g200.jpg','benchSciPubmedId':'36040807'},{'sku':'12-0451-82','imageId':'1020254','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time\u003d20240507','sortOrder':'10','description':'1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%), whereas a low percentage of potential macrophages (CD11b+/CD45 high, Q2) were observed. [(c), (h)] Forward scatter (FSC) analysis showing a slight smaller size of the CD45 low cells (red) respect to CD45 high (blue) cells. [(d), (i)] CD11b analysis showed a slight lower expression within CD45 low cells (red) respect to CD45 high (blue) cells. [(e), (j)] Forward scatter (FSC) and side scatter (SSC) characteristics of CD11b+/CD45 low (red) and CD11b+/CD45 high (blue) are shown','shortDescription':'1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Glia','journalText':'Glia 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg','benchSciPubmedId':'35943203'},{'sku':'12-0451-82','imageId':'1131754','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time\u003d20240507','sortOrder':'11','description':'Extended Data Fig. 3 Gating strategies for cell sorting. Panels a-d, e-h, i-l and m-p represents gating strategies for Fig. 3a, b, h and k . Briefly, a panel represents the gating for cells, eliminating the cell debris followed by single cell selection in b , eliminating doublets. Panel c represents gating strategy for live/dead cells. Live cells selected from c , was subjected to cell sorting based on EpCam and CD45 cells in d . Sorted cells obtained from d was analyzed in Fig. 3a . The same chronology is maintained for panels: e-h, i-l and m-p .','shortDescription':'Extended Data Fig. 3 Gating strategies for cell sorting. Panels a-d, e-h, i-l and m-p represents gating strategies for Fig. 3a, b, h and k . Briefly, a panel represents the gating for cells, eliminating the cell debris followed by single cell selection in b , eliminating doublets. Panel c represents gating strategy for live/dead cells. Live cells selected from c , was subjected to cell sorting based on EpCa... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_21207_41586_2022_4895_Fig7_ESM.jpg','benchSciPubmedId':'35768512'},{'sku':'12-0451-82','imageId':'952742','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20586_jciinsight-7-154824-g203.jpg?time\u003d20240507','sortOrder':'12','description':'Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n \u003d 10; afatinib, n \u003d 10; pemigatinib, n \u003d 10. Data are reported as mean +- SEM. ( C ) Unsupervised clustering t-distributed stochastic neighbor embedding (t-SNE) plot overlaid with cluster and their abundance ( D ) identified by unsupervised PhenoGraph clustering of high-dimensional flow cytometry data obtained from CNS (brain and spinal cord) tissue at peak of disease from mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5). ( E and F ) Quantification ( E ) and scatter plots ( F ) of CD45 - CD11b - , CD45 int CD11b + , CD45 hi CD11b + , and CD45 + CD11b - cell populations in the CNS of mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease. Two-way ANOVA with Sidak\u0027s multiple comparisons test. ( G ) Significant differences in CNS-resident and -infiltrating cell populations in mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease, identified by SAM analysis () (FDR cutoff, 0.1). ( H and I ) Intracellular flow cytometry quantification of iNOS, TNF-alpha, and GM-CSF in astrocytes ( H ) and microglia ( I ) in mice treated with afatinib ( n \u003d 5) or vehicle ( n \u003d 5) at peak of disease. ( J ) Relative expression of','shortDescription':'Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n \u003d 10; afatinib, n \u003d 10; pemigatinib, n \u003d 10. Data are reported as mean +- SEM. ( ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 8, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20586_jciinsight-7-154824-g203.jpg','benchSciPubmedId':'35393953'},{'sku':'12-0451-82','imageId':'1020311','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_21405_jci-132-157338-g101.jpg?time\u003d20240507','sortOrder':'13','description':'Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n \u003d 5-6, ** P \u003c 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n \u003d 5-6, ** P \u003c 0.01). ( D ) CFE of mouse AEC2s isolated from young and old mouse lungs ( n \u003d 6-7, ** P \u003c 0.01). ( E and F ) Flow cytometry analysis of ZIP8 expression in gated AEC2s cultured with medium only or medium containing 100 muM ZnSO 4 ( n \u003d 6, *** P \u003c 0.001). ( G - J ) 3D organoid culture of AEC2s isolated from lungs of 2.5-, 12-, 14-, and 18-month-old mice with and without 100 muM ZnSO 4 treatment. ( G ) CFE ( n \u003d 3-4, * P \u003c 0.05, *** P \u003c 0.001, **** P \u003c 0.0001 by ANOVA). ( H - J ) Expression of Slc39a8 ( H ), Sftpc ( I ), and Pdpn ( J ) in AEC2s derived from 3D-cultured organoids with and without ZnSO 4 treatment by qPCR ( n \u003d 3-4, * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001, **** P \u003c 0.0001 by ANOVA). ( K ) Violin plots of gene expression in AEC2s from lungs of bleomycin-treated young and old mice. ( L ) IPA pathway analysis of AEC2s from young and old mice on day 4 after bleomycin injury. ( M and N ) CFE of AEC2s from uninjured 10- to 12-week-old young mice treated with SRT1720 ( n \u003d 3-6, ** P \u003c 0.01, **** P \u003c 0.0001 by ANOVA) ( M ) and splitomicin ( n \u003d 5-6, **** P \u003c 0.0001 by ANOVA) ( N','shortDescription':'Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n \u003d 5-6, ** P \u003c 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n \u003d 5-6, ** P \u003c 0.01). ( ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_21405_jci-132-157338-g101.jpg','benchSciPubmedId':'35389887'},{'sku':'12-0451-82','imageId':'952697','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'14','description':'Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) under light microscopy. D Representative karyotype analysis. Control MSCs (left, P6) and IL10-MSCs (right, P6) both had normal karyotypes. E Flow cytometric analysis showed IL10-MSCs were positive (\u003e 95%) for mesenchymal lineage markers (CD73, CD90, and CD105) and negative (\u003c 2%) for hematopoietic and endothelial markers (CD14, CD19, CD34, CD45, and CD3) as well as for HLA-DR, in accordance with the criteria of clinical-grade MSCs. F1-2 Tumorigenesis analysis showed that there was no tumor formation observed in any SCID mice injected with IL10-MSCs, but tumor was formed in positive control SCID mice with HESCs transplantation. Further H\u0026E staining showed no infiltration of tumor cells at the cell injection site and main organs after IL10-MSC injection. G - I Differentiation potential of IL10-MSCs in adipocytes, osteocytes, and chondrocytes stained with Oil red O, Alizarin Red, and Alcian Blue, respectively. IL10-MSCs maintained multiple lineage potential, but with downregulated adipogenic differentiation capability','shortDescription':'Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 17, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cellular \u0026 molecular biology letters','journalText':'Cellular \u0026 molecular biology letters 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20584_11658_2022_325_Fig1_HTML.jpg','benchSciPubmedId':'35300585'},{'sku':'12-0451-82','imageId':'1020292','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24777_ppat.1010342.g002.jpg?time\u003d20240507','sortOrder':'15','description':'10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar \u003d 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Leukocytes (C), T lymphocytes (D), total monocytes (E), natural killers (F), B lymphocytes (G), myeloid-derived cells (H), neutrophils (I), infiltrating monocytes (J), and macrophages (K) were evaluated in WT and BEX1 KO hearts at the indicated post-infection time points using flow cytometry. d \u003d days. Statistical analyses by 2-way ANOVA. (* p\u003c0.05 CVB3-treated WT vs. uninfected WT; \u0026 p\u003c0.05 CVB3-treated BEX1 KO vs. uninfected BEX1 KO; # p\u003c0.05 BEX1 KO vs. WT same treatment).','shortDescription':'10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar \u003d 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Le... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS pathogens','journalText':'PLoS pathogens 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24777_ppat.1010342.g002.jpg','benchSciPubmedId':'35192678'},{'sku':'12-0451-82','imageId':'1020273','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19229_LSA-2021-01315_FigS1.jpg?time\u003d20240507','sortOrder':'16','description':'Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untreated and percentages of CD301 + of F4/80 + macrophages were determined by flow cytometry analysis. (D) Representative blots for Fig 1D . (E) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, and/or Etanercept and percentages of Arg1 + of F4/80 + macrophages were determined by flow cytometry analysis. Data represent three independent experiments. (F) Gating strategy for the sorting of wound macrophages. Representative flow cytometry analysis of single cell suspensions isolated from Balb/c wild-type wound tissue at 14 dpi. 7-AAD - single cells were gated and analyzed for expression of CD45 and CD11b. 7-AAD - CD45 + CD11b + cells were gated and analyzed for expression of CD11b and F4/80. 7-AAD - CD45 + CD11b + F4/80 + cells were sorted by flow cytometry. (G) Gating strategy of small peritoneal macrophages from solvent or Etanercept-treated mice stained for Arg1 and RELMalpha. All values are means +- SEM; * P \u003c 0.05; **** P \u003c 0.0001. Statistically significant differences were determined by one-way ANOVA with Tukey correction. If not indicated otherwise superscripts','shortDescription':'Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untrea... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Life science alliance','journalText':'Life science alliance 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19229_LSA-2021-01315_FigS1.jpg','benchSciPubmedId':'35027468'},{'sku':'12-0451-82','imageId':'933482','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time\u003d20240507','sortOrder':'17','description':'Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells versus CD3 + CD4 + Foxp3 + Tregs ( G ); flow cytometry analysis of CD45 + , F4/80 + ( H ) and quantitative analysis ( I , J ) in the distant tumor','shortDescription':'Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells ver... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 19, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of nanobiotechnology','journalText':'Journal of nanobiotechnology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19144_12951_2021_1162_Fig11_HTML.jpg','benchSciPubmedId':'34923976'},{'sku':'12-0451-82','imageId':'933459','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'18','description':'Fig. 2 Reduced neuroinflammation in CD4-P2Y10-KOs. a Neurological score ( n \u003d 8; * p \u003d 0.037 (d24), 0.0189 (d25)). b Quantification of demyelination by luxol fast blue (LFB) staining on day 28 after induction of EAE: Exemplary photomicrographs (left) and statistical evaluation (right) ( n \u003d 8; * p \u003d 0.039). Repetition of EAE in an independent cohort ( n \u003d 8-9): Neurological score ( c ; * p \u003d 0.019 (d20), 0.033 (d21)) and flow cytometric analysis of spinal cord-infiltrating leukocytes on day 20 ( d - g ): Absolute numbers of CNS-infiltrating T cells ( d ; ** p \u003d 0.001), proportion of FoxP3, IFNgamma-, IL-17A- ( e ; ** p \u003d 0.008) or GMCSF- ( f ; ** p \u003d 0.003) expressing cells among infiltrating CD4 cells, absolute numbers of CD11b + ,CD45 hi macrophages ( g ; *** p \u003c 0.001). h Quantification of Mac3-positive cells in lumbar CNS: Exemplary photomicrographs (left) and statistical evaluation (right) ( n \u003d 8; ** p \u003d 0.009) (same mice as in a , b ). Data are means +- SEM; comparisons between genotypes were performed using two-tailed unpaired Student\u0027s t- test ( b , d - h ) or two-way ANOVA with Tukey\u0027s multiple comparisons test ( a , c ). n , number of mice per group.','shortDescription':'Fig. 2 Reduced neuroinflammation in CD4-P2Y10-KOs. a Neurological score ( n \u003d 8; * p \u003d 0.037 (d24), 0.0189 (d25)). b Quantification of demyelination by luxol fast blue (LFB) staining on day 28 after induction of EAE: Exemplary photomicrographs (left) and statistical evaluation (right) ( n \u003d 8; * p \u003d 0.039). Repetition of EAE in an independent cohort ( n \u003d 8-9): Neurological score ( c ; * p \u003d 0.019 (d20), 0.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 23, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19142_41467_2021_26882_Fig2_HTML.jpg','benchSciPubmedId':'34815397'},{'sku':'12-0451-82','imageId':'933461','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19102_elife-73215-fig3.jpg?time\u003d20240507','sortOrder':'19','description':'Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Average number of Pax7 + cells per field (~0.15 mm 2 ) in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. n \u003d 6 mice per group. ( C ) Relative mRNA levels of Pax7 in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by performing qPCR (n \u003d 3-5 mice in each group). ( D ) Representative immunoblots showing levels of Pax7 and unrelated protein GAPDH in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( E ) Primary mononuclear cells were isolated from TA muscle of Ern1 fl/fl and Ern1 cKO mice and subjected to FACS analysis for satellite cells. Representative FACS dot plots demonstrating the percentage of alpha7-integrin + cells in 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( F ) Quantification of alpha7-integrin + satellite cells in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by FACS (n \u003d 4 or 5 mice in each group). Data are expressed as mean +- SEM and analyzed by one-way analysis of variance (ANOVA) followed by Tukey\u0027s multiple comparison test. * p \u003c\u003d 0.05, values significantly','shortDescription':'Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Averag... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 23, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19102_elife-73215-fig3.jpg','benchSciPubmedId':'34812145'},{'sku':'12-0451-82','imageId':'933439','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15194_fimmu-12-763067-g001.jpg?time\u003d20240507','sortOrder':'20','description':'Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macrophages; CD206 - and CD206 + represent M1-like and M2-like uterine macrophages, respectively. (B) Dynamic changes of M1-like macrophages, M2-like macrophages and Mphi during peri-implantation period in mice (n\u003e\u003d3). Error bars represent means +- SEM; two-tailed unpaired t-test, ns, not significant, *P \u003c 0.05 or ***P \u003c 0.001.','shortDescription':'Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macropha... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 10, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15194_fimmu-12-763067-g001.jpg','benchSciPubmedId':'34712245'},{'sku':'12-0451-82','imageId':'933412','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'21','description':'Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence images of MSCs showing the expression of MSC-positive markers (CD29, CD44, and SCA1). d Immunophenotypic characterization of MSCs using flow cytometer showing the absolute counts of MSC positive markers such as CD29, CD44, and SCA1, as well as expression of MSC-negative (CD34, CD45, and CD11b). Isotype controls for each antibody were used as controls and FITC/rhodamine-conjugated secondary antibodies were used for their detection. e Bar graph (quantification from four independent experiments (expressed as mean +- standard error)) showing the percentage of cells expressing the MSC-positive and negative markers respectively. f , g Immunophenotypic characterization of BMCs using flow cytometer showing expression various markers (CD29, CD44, CD45, and CD11b). Bar graph expressed as mean +- standard error shows quantification of respective markers from three independent experiments.','shortDescription':'Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence im... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 20, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ Regenerative medicine','journalText':'NPJ Regenerative medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15066_41536_2021_180_Fig1_HTML.jpg','benchSciPubmedId':'34671058'},{'sku':'12-0451-82','imageId':'933420','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15193_gr4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15193_gr4.jpg?time\u003d20240507','sortOrder':'22','description':'Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mass of WT and TGF mice following 2 weeks of control or high-fat diet. ( D ) Flow cytometry for CD45-positive cells (CD45+) in pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. ( E ) qPCR for CD74 normalized to Ppia housekeeping gene from pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. Statistics were calculated using a two-way ANOVA, where * indicates p \u003c 0.05. Data are presented as the mean +- SEM. Group sizes are listed in the order of CD WT, CD TGF, HFD WT, and HFD TGF: (A, B) n \u003d 3, 3; (C) n \u003d 11, 13, 20, 15; (D) n \u003d 4, 4, 4, 4; and (E) n \u003d 12, 10, 11, 10. Figure 4','shortDescription':'Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mas... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular metabolism','journalText':'Molecular metabolism 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15193_gr4.jpg','benchSciPubmedId':'34583010'},{'sku':'12-0451-82','imageId':'933394','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'23','description':'Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized groups were indicated (PTENalpha-unimmunized, n \u003d 4 mice; other groups, n \u003d 5 mice, mean +- s.e.m., * P (d16) \u003d 0.0254, * P (d20) \u003d 0.0339, * P (d22) \u003d 0.0487, * P (d24) \u003d 0.0450, ** P \u003d 0.0077). c The tumor-infiltrating lymphocytes (TILs) were isolated when the tumor volumes of the Mock-immunized group reach 200 mm 3 , and the cells were subjected to flow cytometry analysis. The cell counts of CD45 + cells were used for statistical analysis ( n \u003d 4 mice, mean +- SD, ** P \u003d 0.0044). Gating strategies were shown in Supplementary Fig. 3b . d - g TILs were isolated when the tumor volumes of Mock-immunized group reach 200 mm 3 , and CD45 + cells were sorted, using for 10x scRNA-seq with two replicates. 25,098 cells were identified as 12 clusters utilizing graph-based clustering. d Cd8T cells were further analyzed and identified as 4 clusters utilizing graph-based clustering. e Violin plot of differentiated genes in the 4 clusters of Cd8T cells. The color of each violin is the average expression value of a given gene. f and g Umap and proportion of the 4 clusters of Cd8T cells','shortDescription':'Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 26, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15190_41467_2021_25417_Fig2_HTML.jpg','benchSciPubmedId':'34446716'},{'sku':'12-0451-82','imageId':'933356','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g006.jpg?time\u003d20240507','sortOrder':'24','description':'FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons','shortDescription':'FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 wee... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g006.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'932265','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time\u003d20240507','sortOrder':'25','description':'4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons','shortDescription':'4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 wee... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'932246','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time\u003d20240507','sortOrder':'26','description':'3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of percent of CD11b + CD45 + cells in 16 week mock, 85 week mock, 16 week infected, and 85 week infected cortex. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression. (d) Quantification of percent CD45 hi , P2RY12 + CD45 lo , and P2RY12 neg CD45 lo cells in each group. (e) Representative flow cytometry plots of P2RY12 + CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of percent MHCII + of P2RY12 + CD45 lo -gated cells in each group. (g) Representative flow cytometry plots of P2RY12 neg CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of percent MHCII + of P2RY12 neg CD45 lo -gated cells in each group. These data are representative of two experiments with 6-10 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. (i) Representative images of 16 week ( top row ) and 85 week ( bottom row ) cortical tissue sections collected fr','shortDescription':'3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'933375','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g007.jpg?time\u003d20240507','sortOrder':'27','description':'FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01','shortDescription':'FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g007.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'932284','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time\u003d20240507','sortOrder':'28','description':'5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01','shortDescription':'5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'933337','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g004.jpg?time\u003d20240507','sortOrder':'29','description':'FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001; **** p \u003c 0.0001','shortDescription':'FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expres... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15181_ACEL-20-e13412-g004.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'932303','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time\u003d20240507','sortOrder':'30','description':'6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch\u0027s correction and Dunnett\u0027s multiple comparisons test. Exact p values noted; * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001; **** p \u003c 0.0001','shortDescription':'6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expres... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Aging cell','journalText':'Aging cell 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg','benchSciPubmedId':'34327802'},{'sku':'12-0451-82','imageId':'933317','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15180_elife-66063-fig1.jpg?time\u003d20240507','sortOrder':'31','description':'Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal populations. Bottom: the lineage tree of the perivascular SSC (pvSSC) able to give rise to bone, cartilage, adipose tissue, and stromal populations. BCSP: bone cartilage stroma progenitor; CP: cartilage progenitor; APC: adipogenic progenitor cell; Pre-Ad. : pre-adipocyte; OPC: osteochondrogenic progenitor cell. ( B ) Representative flow cytometric gating strategy for the isolation of ocSSCs (top) and pvSSCs (bottom). ( C ) Representative confocal microscopy images of in vivo derived single-color clonal colonies of renal capsule-transplanted purified ocSSCs (left) and pvSSCs (right) derived from Actin-CreERt Rainbow mice. Three independent transplants per cell type under renal capsules were performed. ( D ) Renal capsule transplant-derived ossicles of purified GFP-labeled ocSSCs (top) and pvSSCs (bottom). Images show the photograph of the kidney with transplant (top left) and GFP signal of graft tissue (bottom left) as well as Movat pentachrome cross-section staining (right). ( E ) Quantification of ocSSC (top) and pvSSC (bottom) graft composition. Results of three separate','shortDescription':'Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 19, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15180_elife-66063-fig1.jpg','benchSciPubmedId':'34280086'},{'sku':'12-0451-82','imageId':'933299','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'32','description':'Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock out CXCL12 gene ( D ). Western blotting for knockout efficiency ( E ). beta-actin was used as a control. CXCL12 measurement in the serum-free conditioned media of MSC CXCL12+/+ and MSC CXCL12-/- by ELISA ( F ). Each point indicates an experiment (horizontal lines: mean)','shortDescription':'Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock ou... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 26, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cellular \u0026 molecular biology letters','journalText':'Cellular \u0026 molecular biology letters 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15178_11658_2021_273_Fig1_HTML.jpg','benchSciPubmedId':'34174813'},{'sku':'12-0451-82','imageId':'933280','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'33','description':'Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. These populations were quantified and presented as the % of all live cells in A (macrophages, CD11b+CD45 high ) and B (microglia, CD11b+Cd45 low ). C Quantification of F4/80+CD11b+ macrophages in the stromal vascular fraction of visceral adipose tissue following Ctr and HFD in males (left) and females (right). F An example of the flow cytometry gating strategy from visceral fat. D , G Peritoneal cavity (PEC) cells were analyzed by flow cytometry (gating example G ) and the percent of F4/80+CD11b+ macrophages of all live cells are presented graphically in D , males on the left and females on the right. n\u003d9-12 total, 3 repeats consisting of 3-4 mice per group. Statistical significance (*) between Ctr (gray bars) and HFD (black bars) were determined by Student\u0027s T test followed by Tukey\u0027s post hoc test','shortDescription':'Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. T... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 21, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15177_12974_2021_2183_Fig3_HTML.jpg','benchSciPubmedId':'34154608'},{'sku':'12-0451-82','imageId':'933242','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'34','description':'Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots generated from ipsilateral cortex and thalamus from sham and PSD 14 brains. The percentage of microglia, peripheral myeloid cells (pMyeloids), and lymphocytes is indicated numerically on the plots. ( B ) Illustration showing location of cortex and thalamus harvest sites from brain sections corresponding to + 1 or - 2 mm from bregma. ( C ) Number of CD45 Int /CD11b + cells in cortex and thalamus for sham and PSD 14 brains. * P \u003c 0.05, unpaired t test.','shortDescription':'Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots genera... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 15, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15176_41598_2021_91998_Fig2_HTML.jpg','benchSciPubmedId':'34131204'},{'sku':'12-0451-82','imageId':'932340','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time\u003d20240507','sortOrder':'35','description':'1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoechst in bone marrow cells from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 50 um. qPCR results of Rankl in BMAT and peripheral adipose tissues, including epididymal (eWAT), inguinal (iWAT), and interscapular (iBAT) ( n \u003d 3 independent biological replicates). Data were compared using one-way ANOVA (** indicates P \u003c 0.01), and error bars are standard deviations. Immunofluorescence staining of RANKL during in vitro adipogenesis of BMSCs from Adipoq Cre ; rankl fl/fl mice ( Rankl -/- ) and rankl fl/fl mice ( Rankl +/+ ). Scale bar \u003d 50 mum. Western blotting analyses of RANKL in BMSCs during in vitro BMSCs adipogenesis ( n \u003d 3 independent biological replicates). Data were compared using an unpaired t -test (** indicates P \u003c 0.01), and error bars are standard deviations.','shortDescription':'1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar \u003d 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoec... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO reports','journalText':'EMBO reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg','benchSciPubmedId':'34121311'},{'sku':'12-0451-82','imageId':'933204','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'36','description':'Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic approach. b , c Tumor-derived single-cell suspensions were analyzed by CyTOF. b Representative CyTOF sorting. c Quantitative results (mean +- SEM, n \u003d 4 mice). Statistical analysis by two-tailed Student\u0027s t -test. d - f Tumor-derived single-cell suspensions were analyzed by flow cytometry. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n \u003d 6 mice, mean +- SEM). Statistical analysis by two-tailed Student\u0027s t -test. e , f Analysis for e CD4 + /CD8 + T cells or f myeloid cells ( n \u003d 6 mice, mean +- SEM). Statistical analysis by two-tailed Student\u0027s t -test. g , h Tissue lysates from normal brains and tumors were subjected to ELISA analysis for g IL-10 and h TGF-beta expression (mean +- SEM, n \u003d 4 mice for IL-6-DeltaEC GBM group and n \u003d 3 mice for other groups). Statistical analysis by two-way ANOVA with Sidak\u0027s test. Source data are provided as a Source data file.','shortDescription':'Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic app... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14979_41467_2021_23832_Fig1_HTML.jpg','benchSciPubmedId':'34103524'},{'sku':'12-0451-82','imageId':'933223','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'37','description':'Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n \u003d 8-12 mice, specific n numbers are shown in the figure). b Mouse survival was monitored for 60 days and subjected to two-sided log-rank Mantel-Cox analysis. MS, median survival. c Tumor volume was analyzed by bioluminescence imaging during days 13-23 (mean +- SEM). Statistical analysis by two-way ANOVA with Dunnett\u0027s test. d - g Tumors were excised 2 days after treatment. Tumor-derived single-cell suspensions were stained with antibodies against CD45, d CD3, e CD11b, f CD4, CD8, CD3, and g Ki67, IFN-gamma, and CD69, followed by flow cytometry analyses. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n \u003d 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher\u0027s LSD test. e - g Quantified results for immune cells ( n \u003d 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher\u0027s LSD test. Source data are provided as a Source data file.','shortDescription':'Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n \u003d 8-12 mice, specific ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14979_41467_2021_23832_Fig2_HTML.jpg','benchSciPubmedId':'34103524'},{'sku':'12-0451-82','imageId':'933185','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15187_fcell-09-672032-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15187_fcell-09-672032-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15187_fcell-09-672032-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15187_fcell-09-672032-g005.jpg?time\u003d20240507','sortOrder':'38','description':'FIGURE 5 Increased apoptosis and aggregation of immune cells in the liver of LAMTOR1 MKO mice. (A) Flow cytometry results (presented with same cell amount). (B) Percentage of dead cells. (C) Percentage of CD45 - cells, CD45 + cells, and the ratio of CD45 + /CD45 - cells within live cells. (D) Percentage of macrophages (F4/80 + CD11b - ), monocytes (F4/80 - CD11b + ), and sum of macrophages and monocytes within live cells. (E) Percentage of M1- and M2-like macrophages in live cells. n \u003d 4. ** P \u003c 0.01 vs. WT. KO, myeloid-specific knockout mice; Mo, monocytes; Mphi, macrophages; WT, wild-type.','shortDescription':'FIGURE 5 Increased apoptosis and aggregation of immune cells in the liver of LAMTOR1 MKO mice. (A) Flow cytometry results (presented with same cell amount). (B) Percentage of dead cells. (C) Percentage of CD45 - cells, CD45 + cells, and the ratio of CD45 + /CD45 - cells within live cells. (D) Percentage of macrophages (F4/80 + CD11b - ), monocytes (F4/80 - CD11b + ), and sum of macrophages and monocytes wit... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cell and developmental biology','journalText':'Frontiers in cell and developmental biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15187_fcell-09-672032-g005.jpg','benchSciPubmedId':'34095141'},{'sku':'12-0451-82','imageId':'933166','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15175_JEV2-10-e12109-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15175_JEV2-10-e12109-g003.jpg?time\u003d20240507','sortOrder':'39','description':'FIGURE 8 CRT mediates efferocytosis of MSC-derived apoVs to modulate T2D liver macrophages in vivo. (a) Representative immunofluorescent (IF) staining images of F4/80 (green) and CD11b (green) in the liver, counterstained by Hoechst (blue). DIO, mice with diet-induced obesity; si-NC-apoV, DIO mice treated by apoVs derived from MSCs transfected by siRNA-negative control; si- CRT -apoV, DIO mice treated by apoVs derived from MSCs transfected by siRNA- CRT . Scale bars, 50 mum. (b) Flow cytometric analysis and the corresponding quantification of the percentages of KCs and MoMFs in hepatic CD45 + cells. KCs, Kupffer cells; MoMFs, monocyte-derived macrophages. N \u003d 5-6 per group. (c) Representative IF staining images of chemokine (C-C motif) ligand 2 (CCL2) (red) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum. (d and e) ELISA analysis of CCL2 in liver lysate (d) and serum (e). N \u003d 6 per group. (f and g) Representative IF staining images of tumor necrosis factor-alpha (TNF-alpha) (red) and CD206 (green) in the liver, counterstained by Hoechst (blue), and the corresponding quantification of fold changes over the DIO group. Scale bars, 50 mum. N \u003d 5-6 per group. (h and i) Quantitative real time polymerase chain reaction (qRT-PCR) analysis of mRNA expression levels of Tnf (h) and interleukin 10 ( Il10 ) (i) in the liver, normalized to beta-actin ( Actb ), and quantification of fold changes over the DIO group. N \u003d 5 per group. (j and k) Enzyme-linked immunosorbent as','shortDescription':'FIGURE 8 CRT mediates efferocytosis of MSC-derived apoVs to modulate T2D liver macrophages in vivo. (a) Representative immunofluorescent (IF) staining images of F4/80 (green) and CD11b (green) in the liver, counterstained by Hoechst (blue). DIO, mice with diet-induced obesity; si-NC-apoV, DIO mice treated by apoVs derived from MSCs transfected by siRNA-negative control; si- CRT -apoV, DIO mice treated by ap... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of extracellular vesicles','journalText':'Journal of extracellular vesicles 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15175_JEV2-10-e12109-g003.jpg','benchSciPubmedId':'34084287'},{'sku':'12-0451-82','imageId':'933147','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15175_JEV2-10-e12109-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15175_JEV2-10-e12109-g002.jpg?time\u003d20240507','sortOrder':'40','description':'FIGURE 3 Efferocytosis of MSC-derived apoVs by liver macrophages alleviates macrophage infiltration in the type 2 diabetes (T2D) liver. (a) Representative confocal microscopy images showing distribution of PKH26-labeled apoVs (red) in the liver, counterstained by Hoechst (blue). After removal of unbound PKH, the stained apoVs were resuspended in PBS and underwent centrifugation, after which the supernatant was used as the negative control (NC) and injected. Scale bars, 50 mum. (b) Representative confocal microscopy images showing uptake of apoVs (red) by macrophages (green) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum in low magnification images and 25 mum in high magnification images. (c) Flow cytometric analysis showing the uptake of apoVs by macrophages in the liver. KCs, Kupffer cells; MoMFs, monocyte-derived macrophages. (d) Representative immunofluorescent (IF) staining images of F4/80 (green) and CD11b (green) in the liver, counterstained by Hoechst (blue). Ctrl, control mice; DIO, mice with diet-induced obesity; apoV, DIO mice treated by apoVs. Scale bars, 50 mum. (e) Flow cytometric analysis and the corresponding quantification of the percentages of KCs and MoMFs in hepatic CD45 + cells. N \u003d 6 per group. (f) Representative IF staining images of chemokine (C-C motif) ligand 2 (CCL2) (red) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum. (g) Enzyme-linked immunosorbent assay (ELISA) analysis of CCL2 in liver lysate and serum. N','shortDescription':'FIGURE 3 Efferocytosis of MSC-derived apoVs by liver macrophages alleviates macrophage infiltration in the type 2 diabetes (T2D) liver. (a) Representative confocal microscopy images showing distribution of PKH26-labeled apoVs (red) in the liver, counterstained by Hoechst (blue). After removal of unbound PKH, the stained apoVs were resuspended in PBS and underwent centrifugation, after which the supernatant ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of extracellular vesicles','journalText':'Journal of extracellular vesicles 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15175_JEV2-10-e12109-g002.jpg','benchSciPubmedId':'34084287'},{'sku':'12-0451-82','imageId':'933261','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15189_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15189_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15189_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15189_gr2.jpg?time\u003d20240507','sortOrder':'41','description':'Figure 2 Mice harboring a conditional deletion of Nox4 in monocyte-derived macrophages are protected from pulmonary fibrosis . WT mice were exposed to chrysotile and BAL was harvested on day 0, 5, 10, 15, and 21. A , representative flow cytometry plots of resident alveolar macrophages (RAM, CD45 + CD11b +/ - Ly6G - CD64 + Ly6c - Siglec F hi ) and monocyte-derived macrophages (MDM, CD45 + CD11b +/ - Ly6G - CD64 + Ly6c - Siglec F low ). Number of flow sorted B , RAMs ( n \u003d 4-5) and C , MDMs ( n \u003d 4-5). D , CCL2 levels in BAL fluid ( n \u003d 4-5). WT and Nox4 -/- Lyz2-cre mice were exposed to MMVF or chrysotile. BAL was performed on day 21. E , Representative flow cytometry plots of RAMs and MDMs. Number of flow sorted F , RAMs ( n \u003d 5) and G , MDMs ( n \u003d 5). H , CCL2 levels in BAL fluid ( n \u003d 5). I , Caspase-3 activity in RAMs ( n \u003d 5) and J , MDMs ( n \u003d 5). ** p \u003c 0.001; *** p \u003c 0.0001. Values shown as mean +- SEM. One-way ANOVA followed by Tukey\u0027s multiple comparison test was utilized.','shortDescription':'Figure 2 Mice harboring a conditional deletion of Nox4 in monocyte-derived macrophages are protected from pulmonary fibrosis . WT mice were exposed to chrysotile and BAL was harvested on day 0, 5, 10, 15, and 21. A , representative flow cytometry plots of resident alveolar macrophages (RAM, CD45 + CD11b +/ - Ly6G - CD64 + Ly6c - Siglec F hi ) and monocyte-derived macrophages (MDM, CD45 + CD11b +/ - Ly6G - C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of biological chemistry','journalText':'The Journal of biological chemistry 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15189_gr2.jpg','benchSciPubmedId':'34023385'},{'sku':'12-0451-82','imageId':'843479','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12875_gr3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12875_gr3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12875_gr3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12875_gr3.jpg?time\u003d20240507','sortOrder':'42','description':'Figure 3 DCs uptake preference of intradermal injected DiO-loaded PLGA nanoparticles in IMQ-induced psoriasis-like mice. (A) Representative immunofluorescence staining of psoriasis-like mice skin section (a) that intradermally injected with DiO-loaded PLGA nanoparticles (after injection for 4 h), enlarged in (b). (B) Representative immunofluorescence staining of SDLN from psoriasis-like mice that intradermally injected with DiO-loaded PLGA nanoparticles (after injection for 1 h), enlarged in (b). Scale bar: 250 mum (enlargement: 50 mum). Blue: nucleus, green: DiO, red: anti-CD11c. (C) Flow cytometry gating strategy to identify and analyze DCs populations in different lymphoid organs. Gating is shown in one representative data of mice at 1 h exposure after treated with S-NPs. After the initial live gating in a forward scatter (FSC) and side scatter (SSC) plot, particle-positive cells were first gated. Among them, DCs from SDLN and spleens were gated in a CD45 versus CD11c plot. (D) PBS controls and different sizes of DiO-loaded PLGA nanoparticles were intradermally administrated in IMQ-induced psoriasis-like mice, and the single-cell suspensions obtained from lymphoid organs were analyzed at 1, 4, 8, 24, and 48 h after particle exposure. Among particle-positive subset in SDLN (D) and spleens (E), comparison between S-NPs and L-NPs detected in these tissues were made. Data are presented as mean +- SEM ( n \u003d 6), ** P \u003c 0.01, * P \u003c 0.05. Figure 3','shortDescription':'Figure 3 DCs uptake preference of intradermal injected DiO-loaded PLGA nanoparticles in IMQ-induced psoriasis-like mice. (A) Representative immunofluorescence staining of psoriasis-like mice skin section (a) that intradermally injected with DiO-loaded PLGA nanoparticles (after injection for 4 h), enlarged in (b). (B) Representative immunofluorescence staining of SDLN from psoriasis-like mice that intraderma... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Acta pharmaceutica Sinica. B','journalText':'Acta pharmaceutica Sinica. B 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12875_gr3.jpg','benchSciPubmedId':'33996416'},{'sku':'12-0451-82','imageId':'933128','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15174_gr1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15174_gr1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15174_gr1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15174_gr1.jpg?time\u003d20240507','sortOrder':'43','description':'Figure 1 BM niche populations identified with current markers (A) Schematic figure of the experimental design depicting stromal components isolated from the BM of NSG mice carrying specific fluorescent reporters. FACS populations were analyzed by RNA-seq. CD31 n \u003d 7; Nes high n \u003d 4; Nes low n \u003d 5; Ng2 n \u003d 3; Osx n \u003d 5; Col low n \u003d 4; Col high n \u003d 5. (B) 3D PCA analysis showing similarities in expression profiles between different stromal components in healthy mice. Each dot represents an experimental replicate. (C) Flow-cytometry analysis of CD45 - Ter119 - BM cells derived from depicted mice showing overlap between markers associated to niche components. (D) Correlation matrix showing similarities between different stromal components in healthy mice. See also Figure S1 .','shortDescription':'Figure 1 BM niche populations identified with current markers (A) Schematic figure of the experimental design depicting stromal components isolated from the BM of NSG mice carrying specific fluorescent reporters. FACS populations were analyzed by RNA-seq. CD31 n \u003d 7; Nes high n \u003d 4; Nes low n \u003d 5; Ng2 n \u003d 3; Osx n \u003d 5; Col low n \u003d 4; Col high n \u003d 5. (B) 3D PCA analysis showing similarities in expression pro... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'May 11, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15174_gr1.jpg','benchSciPubmedId':'33979628'},{'sku':'12-0451-82','imageId':'933108','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15173_395_2021_869_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15173_395_2021_869_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15173_395_2021_869_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15173_395_2021_869_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'44','description':'Fig. 4 Flow cytometry of aortic lysates and whole blood demonstrates leukocyte extravasation into the aortic endothelium by noise and prevention by LysM + cell ablation. Flow cytometry and representative plots in aortic lysates show an increase in count following noise exposure and a reduction in count in all leukocytes ( a ) as well as innate immune leukocytes ( b ). Specifically, monocytes ( c ) and macrophages ( d ) were reduced below baseline control counts and no increase was found in the aorta following both noise exposure and LysM + cell ablation. e All immune cell subsets were found decreased in whole blood of noise-exposed CTR mice or in the DTX-treated groups. Data points are measurements from individual animals; one-way ANOVA with Tukey\u0027s multiple comparison test ( a - e ). * P \u003c 0.05 vs. Control; # P \u003c 0.05 vs. Noise; $ P \u003c 0.05 vs. DTX, + P \u003c 0.05 vs. DTX + Noise','shortDescription':'Fig. 4 Flow cytometry of aortic lysates and whole blood demonstrates leukocyte extravasation into the aortic endothelium by noise and prevention by LysM + cell ablation. Flow cytometry and representative plots in aortic lysates show an increase in count following noise exposure and a reduction in count in all leukocytes ( a ) as well as innate immune leukocytes ( b ). Specifically, monocytes ( c ) and macro... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Basic research in cardiology','journalText':'Basic research in cardiology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15173_395_2021_869_Fig4_HTML.jpg','benchSciPubmedId':'33929610'},{'sku':'12-0451-82','imageId':'933089','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15185_cells-10-00940-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15185_cells-10-00940-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15185_cells-10-00940-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15185_cells-10-00940-g004.jpg?time\u003d20240507','sortOrder':'45','description':'Figure 4 Immune organ weight and cell profiling at day 30 post-HU. ( a ) Thymus and ( b ) spleen weights normalized to body weights at day 30 post-HU. ( c - f ) Results from flow cytometry of whole blood collected from mice at day 30 post-HU. ( c ) Neutrophil within leukocytes population percentages (%, Ly6g+CD11b+/CD45+), ( d ) Lymphocytes within leukocyte population percentage (%, CD11b-/CD45+), ( e ) Neutrophil to lymphocyte ratio (NLR), and ( f ) Total monocyte to leukocyte population percentage (%, CD11b+/CD45+). NL Sham ( n \u003d 12), NL PAD ( n \u003d 12), HU Sham ( n \u003d 11), and HU PAD ( n \u003d 9). * Statistically significant at p \u003c 0.05 by one-way ANOVA with Tukey post-hoc test.','shortDescription':'Figure 4 Immune organ weight and cell profiling at day 30 post-HU. ( a ) Thymus and ( b ) spleen weights normalized to body weights at day 30 post-HU. ( c - f ) Results from flow cytometry of whole blood collected from mice at day 30 post-HU. ( c ) Neutrophil within leukocytes population percentages (%, Ly6g+CD11b+/CD45+), ( d ) Lymphocytes within leukocyte population percentage (%, CD11b-/CD45+), ( e ) Neu... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 19, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15185_cells-10-00940-g004.jpg','benchSciPubmedId':'33921854'},{'sku':'12-0451-82','imageId':'932835','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','sortOrder':'46','description':'Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing IFNgamma, mTOR, and S6K are expressed as the mean +- S.D. * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001.','shortDescription':'Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rap... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Open life sciences','journalText':'Open life sciences 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15147_biol-13-129-g002.jpg','benchSciPubmedId':'33817078'},{'sku':'12-0451-82','imageId':'932854','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','sortOrder':'47','description':'Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing T-bet and Eomesodermin are expressed as the mean +- S.D. * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001.','shortDescription':'Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+R... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Open life sciences','journalText':'Open life sciences 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15147_biol-13-129-g003.jpg','benchSciPubmedId':'33817078'},{'sku':'12-0451-82','imageId':'933051','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'48','description':'Fig. 1 NAD+ declines with age in bone marrow osteoblastic cells. a Protein levels by western blot (left) and relative quantification (right) of band intensity in bone marrow stromal cells from 6- and 24-month-old C57BL/6 female mice cultured with ascorbic acid and beta-glycerophosphate for 5 days; each lane represents one mouse ( n \u003d 4/group). b Relative cellular NAD + levels in cultured osteoblastic cells pooled from 5 mice/group (triplicates of pooled cultures). AFU arbitrary fluorescence units. c , d mRNA levels by qRT-PCR in ( c ) CD45 - cells freshly isolated from 6- and 24-month-old C57BL/6 female mice ( n \u003d 5/group) and d cultured cells described in a . e Protein levels in cultured stromal cells described in a . Bar graphs represent mean +- SD, data analyzed by Student\u0027s t -test.','shortDescription':'Fig. 1 NAD+ declines with age in bone marrow osteoblastic cells. a Protein levels by western blot (left) and relative quantification (right) of band intensity in bone marrow stromal cells from 6- and 24-month-old C57BL/6 female mice cultured with ascorbic acid and beta-glycerophosphate for 5 days; each lane represents one mouse ( n \u003d 4/group). b Relative cellular NAD + levels in cultured osteoblastic cells ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ aging and mechanisms of disease','journalText':'NPJ aging and mechanisms of disease 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15183_41514_2021_58_Fig1_HTML.jpg','benchSciPubmedId':'33795658'},{'sku':'12-0451-82','imageId':'933049','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15061_mmcfigs2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15061_mmcfigs2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15061_mmcfigs2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15061_mmcfigs2.jpg?time\u003d20240507','sortOrder':'49','description':'Fig. 2 Fig. S2. OVX leads to decreased bone mass and osteogenic differentiation defects in BMMSCs. (A) Micro-CT analysis of trabecular bone mass in the femurs. (B) Quantitative analysis of bone mineral density (BMD), bone volume to tissue volume (BV/TV), trabecular number (Tb. N) and trabecular separation (Tb. Sp). (C) Flow cytometry analysis of ex vivo expanded BMMSCs revealed positive expression of CD105 and CD29, and negative expression of CD11b, CD45 and CD34. (D) Real-time PCR was performed to detect mRNA expression of ALP and Runx2 on day 5 after osteogenic induction. (E) Alizarin red staining and quantification of mineralized nodules were performed on day 21 after osteogenic induction. (F) Western blotting analysis and quantification of the osteogenic-related proteins ALP and Runx2 on day 10 after osteogenic induction. n \u003d 6 per group. Data are presented as mean +- SD; *P \u003c 0.05; **P \u003c 0.01 by unpaired Student\u0027s t -test. Fig. 2','shortDescription':'Fig. 2 Fig. S2. OVX leads to decreased bone mass and osteogenic differentiation defects in BMMSCs. (A) Micro-CT analysis of trabecular bone mass in the femurs. (B) Quantitative analysis of bone mineral density (BMD), bone volume to tissue volume (BV/TV), trabecular number (Tb. N) and trabecular separation (Tb. Sp). (C) Flow cytometry analysis of ex vivo expanded BMMSCs revealed positive expression of CD105 ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Bioactive materials','journalText':'Bioactive materials 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15061_mmcfigs2.jpg','benchSciPubmedId':'33778195'},{'sku':'12-0451-82','imageId':'932131','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time\u003d20240507','sortOrder':'50','description':'3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells lose functional CXCL12 expression but still express GFP in a Cxcl12 promoter/enhancer-dependent manner. ( B ) CD45 staining of Control (left panels) and Col2a1-CXCL12 cKO (right panels) bone marrow. Dotted area \u003d magnified view of Cxcl12 -GFP + reticular stromal cells and neighboring CD45 + hematopoietic cells. Green \u003d Cxcl12-GFP; red \u003d tdTomato; magenta \u003d CD45-Alexa647; gray \u003d DAPI. Scale bar \u003d 10 mum. n \u003d 4 mice per group. ( C ) Flow cytometry analysis of Control and Col2a1-CXCL12 cKO bone marrow cells. The percentage of CD45 + cells in total bone marrow cells (center) and CD45 + GFP + cells in whole GFP + fraction (right). n \u003d 4 mice per group. Two-tailed, Mann-Whitney U test. All data are presented as mean +- SD.','shortDescription':'3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells los... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research','journalText':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg','benchSciPubmedId':'33651379'},{'sku':'12-0451-82','imageId':'843448','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12873_SN-ENUJ210063F005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12873_SN-ENUJ210063F005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12873_SN-ENUJ210063F005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12873_SN-ENUJ210063F005.jpg?time\u003d20240507','sortOrder':'51','description':'Figure 5. Treatment with anti-CCL3 FANA ASOs reduced CD11b+ macrophages at the lesion site. A , B. Flow cytometry 1 d after SCI in anti-CCL3-FANA ASO and control-treated animals did not reveal a significant difference in Gr-1+ neutrophils. Numbers were assessed in the CD11b+CD45+ gated cell population. The negative control was stained with CD11b+CD45+ in absence of the Gr-1 antibody. A , Representative flow cytometry images. B , Quantification of CD11b+CD45+Gr-1+ neutrophils. C , Representative images of CD11b+ macrophages/microglia, GFAP+ astrocytes, and SMI-32+ profiles as indicators of axonal damage adjacent to the lesion epicenter in anti-CCL3-FANA ASO and control-treated animals. The schematic indicates the location of the quantified region (square) next to the lesion (red circle). D , Quantification revealed a significant reduction of CD11b+ macrophages/microglia in the anti-CCL3-FANA ASO treatment group, while neither astrocytes nor indicators of axonal damage were different between groups; n \u003d 5/group, data points are represented as mean +- SEM; * p \u003d 0.01. Scale bars: 80 mum.','shortDescription':'Figure 5. Treatment with anti-CCL3 FANA ASOs reduced CD11b+ macrophages at the lesion site. A , B. Flow cytometry 1 d after SCI in anti-CCL3-FANA ASO and control-treated animals did not reveal a significant difference in Gr-1+ neutrophils. Numbers were assessed in the CD11b+CD45+ gated cell population. The negative control was stained with CD11b+CD45+ in absence of the Gr-1 antibody. A , Representative flow... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 18, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eNeuro','journalText':'eNeuro 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12873_SN-ENUJ210063F005.jpg','benchSciPubmedId':'33632814'},{'sku':'12-0451-82','imageId':'854836','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','sortOrder':'52','description':'Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ) Flow cytometry analysis for immunophenotyping showed that MSCs, in passages 7-8, were positive for CD 29 (98.8%), SCA-1 (98.2%), CD 44 (6.02%), CD 90 (4.18%), and CD 105 (4.97%), and negative for CD34 (0.49%), CD 45 (1.37%), and CD 31 (0.05%).','shortDescription':'Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 4, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9883_ijms-22-01546-g001.jpg','benchSciPubmedId':'33557007'},{'sku':'12-0451-82','imageId':'933013','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g017.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g017.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15171_EMBJ-40-e105123-g017.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15171_EMBJ-40-e105123-g017.jpg?time\u003d20240507','sortOrder':'53','description':'Figure 4 Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells in the eye which causes stable YFP expression under the control of the Rosa26 promotor. Flow cytometric measurement of the persistence of YFP + retinal microglia (rMG), cliliary body (cb) MPhi, and corneal (c) MPhi in adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Doublets and dead cells were excluded by FSC-W and viability dye. Representative flow cytometry plots from two independent experiments with at least six mice are displayed. Kinetics of YFP labeling in macrophages of the healthy eye. Symbols represent means +- s.e.m. rMG are shown as squares (2 weeks: n \u003d 10 mice, 12 weeks: n \u003d 9 mice, 24 weeks: n \u003d 12 mice, Kruskal-Wallis ns P \u003e 0.05), cbMPhi are depicted as triangles (2 weeks: n \u003d 4 samples from eight mice, 12 weeks: n \u003d 3 samples from six mice, 24 weeks: n \u003d 6 samples from twelve mice, Kruskal-Wallis ns P \u003e 0.05) and cMPhi as circles (2 weeks: n \u003d 6 mice, 12 weeks: n \u003d 8 mice, 24 weeks: n \u003d 12 mice, one-way ANOVA *** P \u003c 0.0001). Data were obtained from two (cMPhi: 2 weeks, cbMPhi: 2 and 12 weeks), three (rMG: 2 weeks, cbMPhi: 24 weeks), or four (','shortDescription':'Figure 4 Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 15, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The EMBO journal','journalText':'The EMBO journal 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15171_EMBJ-40-e105123-g017.jpg','benchSciPubmedId':'33555074'},{'sku':'12-0451-82','imageId':'932994','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15171_EMBJ-40-e105123-g009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15171_EMBJ-40-e105123-g009.jpg?time\u003d20240507','sortOrder':'54','description':'Figure 3 Prenatal source of eye macrophages Left: Creation of Acta1 GFP/+ :Acta1 +/+ bone marrow chimeras. Right: Donor-derived GFP + CD45 lo CD11b + were detectable in the recipient retina by flow cytometry 20 weeks after bone marrow reconstitution. FACS Plots are representative for five animals from one experiment. Quantification of GFP + cells among CD45 + CD11b + retinal microglia by flow cytometry. Data are presented as mean +- s.e.m. One symbol represents one mouse. Typical retinal flat mount from Acta1 GFP/+ :Acta1 +/+ bone marrow chimeras 20 weeks after reconstitution. Donor-derived GFP + Iba1 + cells (arrow) and GFP - Iba1 + resident microglia (asterisks) are shown. Pictures are representative for three animals from one experiment. Scale bars represent 50 um. Microscopy-based quantification of GFP + Iba1 + retinal microglia in the inner (IPL) and outer plexiform layer (OPL). One symbol represents one mouse. Data are presented as mean +- s.e.m. Scheme of a fate mapping experiment using Cx3cr1 CreERT2 :Rosa26-YFP female mice. Tamoxifen (TAM) and progesterone injection were performed at embryonic day 9.0 (E9.0). Mice were subsequently evaluated at postnatal day 0 (P0). Administration of TAM leads to intra-embryonic excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells which causes stable and steady YFP expression under the control of the Rosa26 promotor. Direct fluorescence microscopic visualization for YFP (green), the macrophage','shortDescription':'Figure 3 Prenatal source of eye macrophages Left: Creation of Acta1 GFP/+ :Acta1 +/+ bone marrow chimeras. Right: Donor-derived GFP + CD45 lo CD11b + were detectable in the recipient retina by flow cytometry 20 weeks after bone marrow reconstitution. FACS Plots are representative for five animals from one experiment. Quantification of GFP + cells among CD45 + CD11b + retinal microglia by flow cytometry. Dat... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 15, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The EMBO journal','journalText':'The EMBO journal 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15171_EMBJ-40-e105123-g009.jpg','benchSciPubmedId':'33555074'},{'sku':'12-0451-82','imageId':'932322','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time\u003d20240507','sortOrder':'55','description':'4 Figure Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells in the eye which causes stable YFP expression under the control of the Rosa26 promotor. Flow cytometric measurement of the persistence of YFP + retinal microglia (rMG), cliliary body (cb) MPhi, and corneal (c) MPhi in adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Doublets and dead cells were excluded by FSC-W and viability dye. Representative flow cytometry plots from two independent experiments with at least six mice are displayed. Kinetics of YFP labeling in macrophages of the healthy eye. Symbols represent means +- s.e.m. rMG are shown as squares (2 weeks: n \u003d 10 mice, 12 weeks: n \u003d 9 mice, 24 weeks: n \u003d 12 mice, Kruskal-Wallis ns P \u003e 0.05), cbMPhi are depicted as triangles (2 weeks: n \u003d 4 samples from eight mice, 12 weeks: n \u003d 3 samples from six mice, 24 weeks: n \u003d 6 samples from twelve mice, Kruskal-Wallis ns P \u003e 0.05) and cMPhi as circles (2 weeks: n \u003d 6 mice, 12 weeks: n \u003d 8 mice, 24 weeks: n \u003d 12 mice, one-way ANOVA *** P \u003c 0.0001). Data were obtained from two (cMPhi: 2 weeks, cbMPhi: 2 and 12 weeks), three (rMG: 2 weeks, cbMPhi: 24 weeks), or four (','shortDescription':'4 Figure Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 15, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The EMBO journal','journalText':'The EMBO journal 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg','benchSciPubmedId':'33555074'},{'sku':'12-0451-82','imageId':'932778','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'56','description':'Fig. 1 a Gating strategy for determination of Treg frequency (i) \u003d initial population, (ii) \u003d singlets, (iii) \u003d live cells, (iv) \u003d lymphocytes, (v) \u003d CD45hi cells, (vi) \u003d CD3+ cells (T cells), (vii) \u003d CD4+ T cells vs. CD8+ T cells, (viii) \u003d CD4+ CD25+ FoxP3+ cells (quadrant in red) designated Tregs. b Flow cytometric analysis of splenic Treg frequencies in a mouse model of brain ischaemia. 15-17-week-old male, C57BL/6 mice underwent permanent middle cerebral artery occlusion (pMCAO). At 2, 24, and 48 h post-ischaemia, mice received either saline or fingolimod (0.5 mg/kg or 1 mg/kg) by intraperitoneal injection ( n \u003d 16 mice per group). Age-matched mice who had not undergone pMCAO acted as immunological controls ( n \u003d 8). At 7 days post-ischaemia, flow cytometry was used to determine the frequency of splenic Treg cells. All gates were determined by both negative cells and fluorescence minus one controls','shortDescription':'Fig. 1 a Gating strategy for determination of Treg frequency (i) \u003d initial population, (ii) \u003d singlets, (iii) \u003d live cells, (iv) \u003d lymphocytes, (v) \u003d CD45hi cells, (vi) \u003d CD3+ cells (T cells), (vii) \u003d CD4+ T cells vs. CD8+ T cells, (viii) \u003d CD4+ CD25+ FoxP3+ cells (quadrant in red) designated Tregs. b Flow cytometric analysis of splenic Treg frequencies in a mouse model of brain ischaemia. 15-17-week-old ma... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jan 30, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14831_12974_2021_2083_Fig1_HTML.jpg','benchSciPubmedId':'33516262'},{'sku':'12-0451-82','imageId':'855317','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9905_fimmu-11-607564-g010.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9905_fimmu-11-607564-g010.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9905_fimmu-11-607564-g010.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9905_fimmu-11-607564-g010.jpg?time\u003d20240507','sortOrder':'57','description':'Figure 10 F240B inhibits the NLRP3 inflammasome and inflammation in a mouse model of gouty inflammation. (A) Neutrophil and peritoneal lavage cells influx were quantified by Gr-1 and CD45 staining and cell count, respectively. (B, C) The expression levels of IL-1beta, active caspase-1, IL-6 and MCP-1 in the peritoneal lavage fluids were measured by ELISA. The ELISA data expressed as mean +- SD of three separate experiments. *, ** and *** indicate a significant difference at the level of p \u003c 0.05, p \u003c 0.01 and p \u003c 0.001, respectively, compared to MSU crystal-injected mice. ### indicates a significant difference at the level of p \u003c 0.001 compared to control mice.','shortDescription':'Figure 10 F240B inhibits the NLRP3 inflammasome and inflammation in a mouse model of gouty inflammation. (A) Neutrophil and peritoneal lavage cells influx were quantified by Gr-1 and CD45 staining and cell count, respectively. (B, C) The expression levels of IL-1beta, active caspase-1, IL-6 and MCP-1 in the peritoneal lavage fluids were measured by ELISA. The ELISA data expressed as mean +- SD of three sepa... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 23, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9905_fimmu-11-607564-g010.jpg','benchSciPubmedId':'33424855'},{'sku':'12-0451-82','imageId':'855339','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'58','description':'Fig. 2 Bp-infected BALB/c mice develop Th17 T RM cells in the nose. Six-week-old C57BL/6 mice and BALB/c mice were infected with 10 6 CFU of B1917GR. Nasal immune cells were collected at indicated time points post challenge (D0-D28). Ten minutes before euthanasia, mice were intravenously injected with anti-CD45-PE antibody enabling us to discriminate T RM cells from circulating cells. T RM cells express CD44, CD69, and/or CD103. Cell activation was assessed by nonspecific ex vivo stimulation and intracellular staining of IL-17 and IFN-gamma. Cells were fixed and permeabilized to perform intracellular staining of IL-17 and IFN-gamma. Numbers indicate percentages of events in each square. a Representative graph showing the accumulation of CD103 + CD44 + T RM cells in the nose of BALB/c mice at indicated time points after Bp challenge. b Representative graph comparing the pattern of expression of CD44 (left panels) and CD103 (right panels) in the nose of C57BL/6 (black) and BALB/c mice (gray) at indicated time points after Bp challenge. Numbers indicate mean fluorescence intensities and dotted lines indicate the cut-off between positive and negative cells. c Representative graph showing the proportion of IL-17- and/or IFN-gamma-producing CD4 + T RM cells in the nose of C57BL/6 (left panels) and BALB/c mice (right panels) at indicated time points after Bp challenge. Numbers indicate percentages of events in each square.','shortDescription':'Fig. 2 Bp-infected BALB/c mice develop Th17 T RM cells in the nose. Six-week-old C57BL/6 mice and BALB/c mice were infected with 10 6 CFU of B1917GR. Nasal immune cells were collected at indicated time points post challenge (D0-D28). Ten minutes before euthanasia, mice were intravenously injected with anti-CD45-PE antibody enabling us to discriminate T RM cells from circulating cells. T RM cells express CD4... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jan 8, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ vaccines','journalText':'NPJ vaccines 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9906_41541_2020_270_Fig2_HTML.jpg','benchSciPubmedId':'33420041'},{'sku':'12-0451-82','imageId':'853691','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9861_gr4_lrg.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9861_gr4_lrg.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9861_gr4_lrg.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9861_gr4_lrg.jpg?time\u003d20240507','sortOrder':'59','description':'Figure 4 Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n \u003d 6. (C) Analysis of the rescue effect of Paquinimod by H\u0026E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H\u0026E staining images were randomly selected for pathological scoring. n \u003d 10. Scale bars, 100 mum. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n \u003d 5. Scale bars, 50 mum. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n \u003d 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n \u003d 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were signifi','shortDescription':'Figure 4 Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n \u003d 6. (C) Analysis of the rescue effect of Paquinimod by H\u0026E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinim... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 10, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9861_gr4_lrg.jpg','benchSciPubmedId':'33388094'},{'sku':'12-0451-82','imageId':'853639','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9861_gr3_lrg.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9861_gr3_lrg.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9861_gr3_lrg.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9861_gr3_lrg.jpg?time\u003d20240507','sortOrder':'60','description':'Figure 3 A group of immature aberrant neutrophils emerged in coronavirus-infected mice (A) Immunohistochemical analysis of the location and expression of S100A8 in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi. The S100A8 + cells in the lungs of mice infected with coronavirus were increased significantly. The red arrows indicate the S100A8 + cells. n \u003d 5. Scale bars, 50 mum. (B) Flow cytometry analysis of neutrophils in lungs from mice infected with SARS-CoV-2 and MHV at 5 dpi. Control group means mice treated with vehicle. Gate P1 shows the conventional neutrophils (CD45 + CD11b + Ly6G high ), and Gate P2 shows the pathologic aberrant neutrophils (CD45 + CD11b + Ly6G variable ). Aberrant neutrophils (P2) in the lungs of mice infected with coronavirus were significantly increased. n \u003d 3. (C) Flow cytometry analysis of neutrophils in lungs of mice challenged with IAV, EMCV, HSV-1, and LPS at 5 dpi. The results showed that these treatments did not induce an increase in aberrant neutrophils. n \u003d 3. (D) Flow cytometry analysis of neutrophils in bone marrow from mice infected with SARS-CoV-2 and MHV at 5 dpi. n \u003d 3. (E) qRT-PCR-analyzed related gene expression of aberrant neutrophils in bone marrow of mice infected with MHV at 5 dpi and identified the differentiated types of aberrant neutrophils. n \u003d 3. *** p \u003c 0.001. Error bars, SD.','shortDescription':'Figure 3 A group of immature aberrant neutrophils emerged in coronavirus-infected mice (A) Immunohistochemical analysis of the location and expression of S100A8 in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi. The S100A8 + cells in the lungs of mice infected with coronavirus were increased significantly. The red arrows indicate the S100A8 + cells. n \u003d 5. Scale bars, 50 mum. (B) Flow cyto... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Feb 10, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9861_gr3_lrg.jpg','benchSciPubmedId':'33388094'},{'sku':'12-0451-82','imageId':'933069','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15184_MUS-63-600-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15184_MUS-63-600-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15184_MUS-63-600-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15184_MUS-63-600-g005.jpg?time\u003d20240507','sortOrder':'61','description':'FIGURE 1 Immune cell proportions in skeletal muscle and blood. A, Number of mononuclear cells in skeletal muscle. B, Number of CD11b + F4/80 + cells (macrophages), CD11b + Ly-6G + cells (neutrophils), and CD45 + CD3e + cells (T cells) in skeletal muscle. C, Number of CD11b + F4/80 + , CD11b + Ly-6G + , and CD45 + CD3e + cells in blood','shortDescription':'FIGURE 1 Immune cell proportions in skeletal muscle and blood. A, Number of mononuclear cells in skeletal muscle. B, Number of CD11b + F4/80 + cells (macrophages), CD11b + Ly-6G + cells (neutrophils), and CD45 + CD3e + cells (T cells) in skeletal muscle. C, Number of CD11b + F4/80 + , CD11b + Ly-6G + , and CD45 + CD3e + cells in blood','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Muscle \u0026 nerve','journalText':'Muscle \u0026 nerve 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15184_MUS-63-600-g005.jpg','benchSciPubmedId':'33386611'},{'sku':'12-0451-82','imageId':'932721','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15182_fnut-07-583186-g0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15182_fnut-07-583186-g0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15182_fnut-07-583186-g0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15182_fnut-07-583186-g0003.jpg?time\u003d20240507','sortOrder':'62','description':'Figure 3 SP reduces the total B cell population and controls B cell subset populations in old mice. (A) Splenic cells were stained with anti-CD19-FITC. In the right-hand dot plots, CD3+ T cells were gated electronically. Representative data from young and old mice are shown. The numbers inside the plots represent the percentage of each cell population (mean +- SEM; n \u003d 3). Fluorescence scales are logarithmic. (B) The concentration of IL-6 in serum from experimental mice, as determined by ELISA at weeks 0, 2, 4, and 6 (mean +- SEM; n \u003d 4). (C) Cells were stained with anti-CD19-FITC and anti-CD45R-PE. The B1REL and B2 cell compartments were identified as CD19+ CD45Rlow (B1REL, left gate) and CD19+ CD45R+ (B2, right gate), respectively. Representative data from young and old mice are shown. The numbers inside the plots represent the percentage of each cell population (mean +- SEM; n \u003d 3). The fluorescence scales are logarithmic. Statistical significance was determined using one-way ANOVA followed by Tukey\u0027s post-hoc test. Datasets denoted by different letters are significantly different ( p \u003c 0.05).','shortDescription':'Figure 3 SP reduces the total B cell population and controls B cell subset populations in old mice. (A) Splenic cells were stained with anti-CD19-FITC. In the right-hand dot plots, CD3+ T cells were gated electronically. Representative data from young and old mice are shown. The numbers inside the plots represent the percentage of each cell population (mean +- SEM; n \u003d 3). Fluorescence scales are logarithmi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 18, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in nutrition','journalText':'Frontiers in nutrition 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15182_fnut-07-583186-g0003.jpg','benchSciPubmedId':'33330583'},{'sku':'12-0451-82','imageId':'932740','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'63','description':'Fig. 1 Increased human and mouse blood and heart EOS count after MI. a EOS count per liter blood in men with ( n \u003d 345) and without ( n \u003d 5,519) AMI ( P \u003d 3.3 x 10E-9). b . Spearman correlation between LV EF and blood EOS count among a subgroup of 482 men who had the echocardiography results available ( r \u003d -0.122, P \u003d 0.013). c . FACS strategy to analyze heart and blood EOS from WT mice at 1-day post-MI. d Representative FACS images of heart EOS from WT sham at 1-day after operation. EOS-deficient DeltadblGATA sham mice served as negative control. e FACS analysis of blood EOS in WT sham and MI mice at 1-day after surgery. Representative FACS images are shown to the left. f . FACS analysis determined heart EOS count or percentage among total CD45 + cells in WT MI and sham mice at different days after surgery. g , h Anti-mouse GFP antibody detection of GFP-positive EOS in the infarct, border, and remote regions from eoCRE +/- GFP +/- mice at 1-day post-MI. Representative images are shown to the left ( g ). Heart sections from sham-operated eoCRE +/- GFP +/- mice served as experimental control ( h ). Scale: 30 um, inset: 15 um. i . RT-PCR determined the mRNA levels of EOS relevant chemokines in heart tissues from WT MI and sham mice at 1-day after surgery. Data are mean +- SEM. The numbers of patients ( a ) and mice ( e - g , i ) in each group, and P values ( a , e - g , i ) are indicated, Student\u0027s t-test ( a ), non-parametric Mann-Whitney U test followed by Bonferroni correct','shortDescription':'Fig. 1 Increased human and mouse blood and heart EOS count after MI. a EOS count per liter blood in men with ( n \u003d 345) and without ( n \u003d 5,519) AMI ( P \u003d 3.3 x 10E-9). b . Spearman correlation between LV EF and blood EOS count among a subgroup of 482 men who had the echocardiography results available ( r \u003d -0.122, P \u003d 0.013). c . FACS strategy to analyze heart and blood EOS from WT mice at 1-day post-MI. d... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19138_41467_2020_19297_Fig1_HTML.jpg','benchSciPubmedId':'33328477'},{'sku':'12-0451-82','imageId':'932759','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'64','description':'Fig. 3 EOS deficiency affects heart acute immune cell accumulation post-MI. a FACS quantification of different immune cells in percentage of total CD45 + cells at different time points post-MI. b CD45 + CD11b + Gr-1 + neutrophils at 1-day after surgery. c RT-PCR determined the mRNA levels of neutrophil relevant chemokines (Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcl7) in heart from WT and DeltadblGATA mice at 1-day post-MI. d, e CD45 + CD11b + Ly6C hi and CD45 + CD11b + Ly6C lo monocytes at 3 days ( d ) and 5 days ( e ) after surgery. f CD45 + CD11c + MHC-II + dendritic cells at 5 days after surgery. g CD45 + CD4 + CD8 - and CD4 - CD8 + T cells at 7 days after surgery. h FACS gating strategy. Data are mean +- SEM. The numbers of mice in each experimental group and P values are indicated, one-way ANOVA test ( b , d - g ) and non-parametric Mann-Whitney U test ( c ).','shortDescription':'Fig. 3 EOS deficiency affects heart acute immune cell accumulation post-MI. a FACS quantification of different immune cells in percentage of total CD45 + cells at different time points post-MI. b CD45 + CD11b + Gr-1 + neutrophils at 1-day after surgery. c RT-PCR determined the mRNA levels of neutrophil relevant chemokines (Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcl7) in heart from WT and DeltadblGATA mice at 1-day po... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19138_41467_2020_19297_Fig3_HTML.jpg','benchSciPubmedId':'33328477'},{'sku':'12-0451-82','imageId':'932113','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time\u003d20240507','sortOrder':'65','description':'1 FIGURE The effects of postmortem delay (PMD) on viable fluorescence-activated cell sorting (FACS)-sorted mouse microglia numbers and RNA quality. (a) FACS plots depicting the sorting strategy of DAPI neg Ly6C neg CD11b high CD45 int microglia and the PMD induced decrease in the percentage of DAPI neg microglia in gate R5. (b) Dot plot depicting the number of DAPI neg microglia sorted from entire mouse brains at different PMD times ( n \u003d 4 mice per PMD). (c) Dot plot depicting RIN values of RNA extracted from sorted DAPI neg Ly6C neg CD11b high CD45 int microglia at different PMD times ( n \u003d 4 mice per PMD). A one-way ANOVA followed by a Bonferroni correction for multiple comparisons was performed to assess significance. **, p \u003c .01; ***, p \u003c .001','shortDescription':'1 FIGURE The effects of postmortem delay (PMD) on viable fluorescence-activated cell sorting (FACS)-sorted mouse microglia numbers and RNA quality. (a) FACS plots depicting the sorting strategy of DAPI neg Ly6C neg CD11b high CD45 int microglia and the PMD induced decrease in the percentage of DAPI neg microglia in gate R5. (b) Dot plot depicting the number of DAPI neg microglia sorted from entire mouse bra... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Glia','journalText':'Glia 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg','benchSciPubmedId':'33296111'},{'sku':'12-0451-82','imageId':'853444','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9859_elife-60223-fig2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig2.jpg?time\u003d20240507','sortOrder':'66','description':'Figure 2. Immune cell profiles in axotomized DRGs. ( A ) Representative images of L4 DRG cross sections from naive mice, d1, d3, and d7 post-SNC. Macrophages were stained with anti-Iba1 and anti-F4/80. Neurons were stained with anti-NFH. Scale bar, 50 um. ( B ) Quantification of granulocytes per DRG detected by flow cytometry. For flow cytometry of DRGs, naive mice (n \u003d 14 biological replicates), d1 (n \u003d 3), d3 (n \u003d 5), and d7 (n \u003d 12) post-SNC mice were used. Granulocytes (CD45 + , CD11b + , Ly6G + ) per DRG are shown. ( C ) Quantification of Mo/Mac (CD45 + , CD11b + , CD11c - , Ly6G - ) per DRG. ( D ) Quantification of MoDC (CD45 + , CD11b + , CD11c + , Ly6G - ) per DRG. ( E ) Quantification of cDC (CD45 + , CD11b - , CD11c + , Ly6G - ) per DRG. ( F ) Quantification of lymphocytes (CD45+, CD11b - ) per DRG. ( G ) Composition of CD45 + leukocytes in lumbar DRGs identified by flow cytometry. Flow data are represented as mean cell number +- SEM. Each data point represents L3-L5 DRGs pooled from three to four animals (18-24 DRGs), biological replicates, n \u003d 3-14. Statistical analysis was performed in GraphPad Prism (v7) using one-way or two-way ANOVA with correction for multiple comparisons with Tukey\u0027s post-hoc test. For B-F, unpaired two-tailed t-test with Welch\u0027s correction. A p value \u003c 0.05 (*) was considered significant. p\u003c0.01 (**), p\u003c0.001 (***), and p\u003c0.0001 (****). ( H ) Western blots analysis of DRGs and sciatic nerves (SNs) prepared from sham operated mice and mice a','shortDescription':'Figure 2. Immune cell profiles in axotomized DRGs. ( A ) Representative images of L4 DRG cross sections from naive mice, d1, d3, and d7 post-SNC. Macrophages were stained with anti-Iba1 and anti-F4/80. Neurons were stained with anti-NFH. Scale bar, 50 um. ( B ) Quantification of granulocytes per DRG detected by flow cytometry. For flow cytometry of DRGs, naive mice (n \u003d 14 biological replicates), d1 (n \u003d 3)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 2, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9859_elife-60223-fig2.jpg','benchSciPubmedId':'33263277'},{'sku':'12-0451-82','imageId':'853526','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9859_elife-60223-fig6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig6.jpg?time\u003d20240507','sortOrder':'67','description':'Figure 6. Macrophage subpopulation in the injured nerve are functionally distinct and localize to specific sites. ( A-E ) Feature plots of Adgre1 (F4/80), Aif1 (Iba1), Cd68 (Scavenger receptor class D) , Cx3cr1 (Fractalkine receptor), and CD209a (DC-SIGN) expression in the d3 post-SNC nerve. ( F ) scRNAseq dot plot analysis of transcription regulators (TRs) enriched in leukocytes. Average gene expression and percentage of cells expressing the TR are shown. ( G ) Violin plot of Ly6c2 (Ly6C) expression in immune cells of the d3 post-SNC nerve. ( H-K ) Flow cytometric analysis of sciatic nerve Mo/Mac (CD45 + , CD11b + , Ly6G - , CD11c - ) in naive mice, d1, d3, and d7 post-SNC mice. Mo/Mac maturation was assessed by Ly6C surface staining. ( L, M ) Quantification of Ly6C distribution on Mo/Mac in naive nerves and at different post-SNC time points (n \u003d 11 biological replicates per time point); ( L ) Percentile of Ly6C - , Ly6C int , and Ly6C hi Mo/Mac and ( M ) number of Ly6C - , Ly6C int , and Ly6C hi Mo/Mac. Flow data are represented as mean +- SEM. Statistical analysis was performed in GraphPad Prism (v7) using one-way or two-way ANOVA with correction for multiple comparisons with Tukey\u0027s post-hoc test. A p value \u003c 0.05 (*) was considered significant. p\u003c0.01 (**), p\u003c0.001 (***), and p\u003c0.0001 (****). ( N ) Feature plot showing Arg1 (Arginase-1) expression in the 3d post-SNC nerve. ( O-Q ) Longitudinal sciatic nerve sections of Arg1-YFP reporter mice, from naive mice ( O ), d3 (','shortDescription':'Figure 6. Macrophage subpopulation in the injured nerve are functionally distinct and localize to specific sites. ( A-E ) Feature plots of Adgre1 (F4/80), Aif1 (Iba1), Cd68 (Scavenger receptor class D) , Cx3cr1 (Fractalkine receptor), and CD209a (DC-SIGN) expression in the d3 post-SNC nerve. ( F ) scRNAseq dot plot analysis of transcription regulators (TRs) enriched in leukocytes. Average gene expression an... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 2, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9859_elife-60223-fig6.jpg','benchSciPubmedId':'33263277'},{'sku':'12-0451-82','imageId':'853484','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9859_elife-60223-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig3.jpg?time\u003d20240507','sortOrder':'68','description':'Figure 3. Sciatic nerve injury triggers massive accumulation of hematogenous leukocytes in the injured nerve but not axotomized DRGs. ( A ) Parbiosis complex of a wildtype (WT) and a tdTomato (tdTom) mouse. Mice were surgically paired at postnatal day 56. The timeline of the experiment is shown. ( B ) Flow cytometric analysis of sciatic nerve trunks collected from non-parabiotic (single) tdTom mice, WT parabionts, and tdTom parabionts. Dotplot of live (CD11b + , tdTom + ) cells in the d3 post-SNC nerve. ( C ) Quantification of tdTom + myeloid cells in the 3d injured nerve of WT single mice (WT-S), WT parabiont (WT-para), tdTom parabiont (tdTom-para), and tdTom single (tdTom-S) mice. The fraction of tdTom + myeloid cells (CD45 + , CD11b + ), MoDC (CD45 + , CD11b + , CD11c + , Ly6G - ), and Mo/Mac (CD45 + , CD11b + , CD11c - , Ly6G - ) is shown. For quantification of tdTom + immune cells, nerves from the WT parabiont and the tdTom parabiont were harvested separately (three mice per data point) with n \u003d 2-3 biological replicates. Flow data are represented as fraction of tdTom + cells +- SEM. Statistical analysis was performed in GraphPad Prism (v8) using one-way ANOVA with correction for multiple comparisons with Tukey\u0027s post-hoc test. p value of \u003c 0.001 (***) and p\u003c0.0001 (****). ( D ) Longitudinal sciatic nerves sections of the WT parabiont at d7 post-SNC. The nerve crush site is marked with a white dotted line, proximal is to the left, distal to the right. Anti-F4/80 (green)','shortDescription':'Figure 3. Sciatic nerve injury triggers massive accumulation of hematogenous leukocytes in the injured nerve but not axotomized DRGs. ( A ) Parbiosis complex of a wildtype (WT) and a tdTomato (tdTom) mouse. Mice were surgically paired at postnatal day 56. The timeline of the experiment is shown. ( B ) Flow cytometric analysis of sciatic nerve trunks collected from non-parabiotic (single) tdTom mice, WT para... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Dec 2, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9859_elife-60223-fig3.jpg','benchSciPubmedId':'33263277'},{'sku':'12-0451-82','imageId':'932702','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'69','description':'Fig. 1 Characterization of murine BMMSCs. a , b Flow cytometric analysis of the surface markers showed positive expression of CD29, CD90, CD105, CD146, and Sca-1, and negative expression of hematopoietic markers CD11b, CD34, and CD45. c Representative image of colony formation of murine BMMSCs. d Representative image of Oil Red O staining of murine BMMSCs. e Representative image of ALP staining of murine BMMSCs. f Representative image of Alizarin red staining of murine BMMSCs. Scale bar, 500 mum','shortDescription':'Fig. 1 Characterization of murine BMMSCs. a , b Flow cytometric analysis of the surface markers showed positive expression of CD29, CD90, CD105, CD146, and Sca-1, and negative expression of hematopoietic markers CD11b, CD34, and CD45. c Representative image of colony formation of murine BMMSCs. d Representative image of Oil Red O staining of murine BMMSCs. e Representative image of ALP staining of murine BM... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 27, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14973_13287_2020_2014_Fig1_HTML.jpg','benchSciPubmedId':'33246491'},{'sku':'12-0451-82','imageId':'932683','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time\u003d20240507','sortOrder':'70','description':'Fig. 9 The NOTCH3 enhancer promotes tumor-initiating activity of NRF2-activated NSCLCs. a Oncosphere growth of DeltaN3U and wild-type (WT) H460 cells (left panel). Scale bars indicate 100 mum. Viable cells were counted after trypsinization (right panel). Average cell numbers and SD from four independent experiments are shown. Comparison was made between two cell groups; WT and each mutant clone. Two-sided Student\u0027s t test was performed. * p \u003c 0.05. b Spheroid growth of DeltaN3U and WT H460 cells (left panels). Scale bars indicate 100 mum. Cell numbers were estimated using a cell counting kit on day 4 (right panel). Average cell numbers and SD from six independent experiments are shown. The average number of WT H460 cells was set as 100%. Two-sided Student\u0027s t test was performed. n.s. : not significant. c Xenograft experiment of DeltaN3U and WT H460 cells ( n \u003d 9 each; number of xenograft tumors). A photograph shows xenograft tumors at the time of tumor weight measurement on day 15. Horizontal bars indicate the median tumor weight (middle panel). Data are presented as mean + SEM (left panel). Two-sided Wilcoxon rank sum test was performed. * p \u003c 0.05. d Xenograft experiment of DeltaN3U H460 Clone 2-2 cells with LacZ and N3ICD ( n \u003d 12 each; number of xenograft tumors). A photograph shows xenograft tumors at the time of tumor weight measurement on day 18. Horizontal bars indicate the median tumor weight (middle panel). Data are presented as mean + SEM (left panel). Two-sided Wi','shortDescription':'Fig. 9 The NOTCH3 enhancer promotes tumor-initiating activity of NRF2-activated NSCLCs. a Oncosphere growth of DeltaN3U and wild-type (WT) H460 cells (left panel). Scale bars indicate 100 mum. Viable cells were counted after trypsinization (right panel). Average cell numbers and SD from four independent experiments are shown. Comparison was made between two cell groups; WT and each mutant clone. Two-sided S... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 20, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15081_41467_2020_19593_Fig9_HTML.jpg','benchSciPubmedId':'33219226'},{'sku':'12-0451-82','imageId':'855279','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9904_fnmol-13-00149-g0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9904_fnmol-13-00149-g0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9904_fnmol-13-00149-g0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9904_fnmol-13-00149-g0002.jpg?time\u003d20240507','sortOrder':'71','description':'Figure 2 Flow cytometry allows for a relative quantification of VGLUT1 immunoreactivity in microglia from both the adult and the developing mouse brain. (A) FACS plot displaying the gates for both microglia (CD11b + CD45 lo population) and brain\u0027s non-myeloid cells (CD11b - CD45 - population). (B) FACS plot showing VGLUT1 immunoreactivity in both microglia and brain\u0027s non-myeloid cells. (C) Microglia from VGLUT1-stained samples exhibit a positive staining, as compared to isotype control. (D) Percentage of the VGLUT1-positive microglia, fluorescence of the isotype control is used as baseline ( N \u003d 6 mice, pooled data from two independent experiments). (E) FACS plot displaying both microglia (CD11b + CD45 lo population) and CD45hi MPs (CD11b + CD45 hi population). (F) Fluorescence peak of the VGLUT1 staining in CD45 hi MPs. (F1) Fluorescence peak of the VGLUT1 staining in microglia (anti-VGLUT1-PE, Merck Millipore FCMAB335PE, clone 3C10.2). (G) Fluorescence peak of the Synaptophysin staining in CD45 hi MPs. (G1) Fluorescence peak of the Synaptophysin staining in microglia. (H) n-MEAN-FLUORESCENCE-INTENSITY (MFI) for VGLUT1 and Synaptophysin in both microglia and CD45 hi MPs (VGLUT1 N \u003d 6 mice per group, pooled data from two independent experiments; Mann-Whitney U -test; ** p \u003d 0.002. Synaptophysin N \u003d 4 mice per group, data from a single experiment; Mann-Whitney U -test unpaired; * p \u003d 0.029). (I) Fluorescence peak of the VGLUT1 staining in microglia using an alternative antibo','shortDescription':'Figure 2 Flow cytometry allows for a relative quantification of VGLUT1 immunoreactivity in microglia from both the adult and the developing mouse brain. (A) FACS plot displaying the gates for both microglia (CD11b + CD45 lo population) and brain\u0027s non-myeloid cells (CD11b - CD45 - population). (B) FACS plot showing VGLUT1 immunoreactivity in both microglia and brain\u0027s non-myeloid cells. (C) Microglia from V... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 3, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in molecular neuroscience','journalText':'Frontiers in molecular neuroscience 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9904_fnmol-13-00149-g0002.jpg','benchSciPubmedId':'33132837'},{'sku':'12-0451-82','imageId':'855298','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9904_Image_3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9904_Image_3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9904_Image_3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9904_Image_3.jpg?time\u003d20240507','sortOrder':'72','description':'Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry','shortDescription':'Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Nov 3, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in molecular neuroscience','journalText':'Frontiers in molecular neuroscience 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9904_Image_3.jpg','benchSciPubmedId':'33132837'},{'sku':'12-0451-82','imageId':'932975','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time\u003d20240507','sortOrder':'73','description':'Fig. 8 Exosomal miR-21 counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). WT-EXOT transplantation of exosomes derived from wild-type mesenchymal stem cells (MSCs) after MNU injection, miR-21 -/- -EXOT transplantation of exosomes derived from miR-21-deficient MSCs after MNU injection, GCL ganglion cell layer, INL inner nuclear layer, ONH optic nerve head. Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for area under curve (AUC). N \u003d 3 per group. Representative scotopic electroretinography (ERG) waveforms ( C ) and the corresponding quantitative analyses of amplitude changes of a-wave ( D ) and b-wave ( E ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. Representative photopic ERG waveforms ( F ) and the corresponding quantitative analysis of b-wave amplitude changes ( G ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL, green) staining images of retinal tissues counterstained by Hoechst 33342 (blue) ( H ) and the corresponding quantitative analysis of percentages of TUNEL + cells over total ONL cells ( J ). Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test. N \u003d 3 per group. Representative TUNEL (green) staining images of retinal tiss','shortDescription':'Fig. 8 Exosomal miR-21 counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). WT-EXOT transplantation of exosomes derived from wild-type mesenchymal stem cells (MSCs) after MNU injection, m... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig8_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'932956','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'74','description':'Fig. 6 miR-21 protects 661W cone photoreceptor cells against N -methyl- N -nitrosourea (MNU)-induced apoptosis and can be transferred from mesenchymal stem cells (MSCs). A Diagram demonstrating the experimental design for analyzing direct effects of miR-21 on 661W cells. NC negative control of miR-21 mimics. B Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of expression levels of miR-21 in 661W cells, normalized to Rnu6 . Ctrl control. * P \u003c 0.05 by the Kruskal-Wallis test. N \u003d 3 per group. Representative flow cytometric images showing death of 661W cone photoreceptor cells ( C ) and the corresponding quantitative analysis of percentages of apoptotic (Annexin V + PI - plus Annexin V + PI + ) 661W cells ( D ). 661W cells were treated with MNU with or without transfection of NC or miR-21 mimics. PI propidium iodide. * P \u003c 0.05 by the Kruskal-Wallis test. N \u003d 3 per group. E Diagram demonstrating the experimental design for analyzing indirect effects of MSCs on 661W cells. WT wild-type mice, miR-21 -/- , mice deficient for miR-21. Representative flow cytometric images showing death of 661W cone photoreceptor cells ( F ) and the corresponding quantitative analysis of percentages of apoptotic (Annexin V + PI - plus Annexin V + PI + ) 661W cells ( G ). MNU-treated 661W cells were co-cultured in the Transwell system with or without different MSCs. * P \u003c 0.05 by the Kruskal-Wallis test. N \u003d 3 per group. H qRT-PCR analysis of expression levels of miR-21 in MSCs, no','shortDescription':'Fig. 6 miR-21 protects 661W cone photoreceptor cells against N -methyl- N -nitrosourea (MNU)-induced apoptosis and can be transferred from mesenchymal stem cells (MSCs). A Diagram demonstrating the experimental design for analyzing direct effects of miR-21 on 661W cells. NC negative control of miR-21 mimics. B Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of expression levels of miR-21... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig6_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'932937','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'75','description':'Fig. 5 miR-21 deficiency aggravates N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration, which is restrained by transplantation of mesenchymal stem cell (MSC)-derived exosomes. A Tracing of CD63-EGFP plasmid-transfected MSCs (green, CD63) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. MSCT mesenchymal stem cell transplantation, INL inner nuclear layer, ONL outer nuclear layer. Scale bar \u003d 50 mum. B Tracing of PKH26-labeled exosomes (red) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. EXOT exosomal transplantation, NC negative control, injection of EXO without staining. Scale bar \u003d 50 mum. C Tracing of PKH26-labeled, MSC-derived exosomes (red) in 661W cone photoreceptor cells during in vitro treatment. 661W cells are demonstrated by beta-tubulin immunostaining for microtubules (green), counterstained by Hoechst 33342 (blue). NC negative control, treatment of EXO without staining. Scale bar \u003d 10 mum. D Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of expression levels of multiple microRNAs in retina tissues, normalized to Rnu6 . Ctrl control. * P \u003c 0.05 by the Mann-Whitney U test. N \u003d 4 per group. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( E ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( F ). WT wild-type mice, miR-21 -/- mice deficient for m','shortDescription':'Fig. 5 miR-21 deficiency aggravates N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration, which is restrained by transplantation of mesenchymal stem cell (MSC)-derived exosomes. A Tracing of CD63-EGFP plasmid-transfected MSCs (green, CD63) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. MSCT mesenchymal stem cell transpla... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig5_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'932918','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'76','description':'Fig. 4 Intravitreal transplantation of mesenchymal stem cells (MSCs) and exosomes (EXO) ameliorates photoreceptor loss and retinal degeneration in the Phosphodiesterase 6b gene mutant ( Pde6b mut ) mouse model. A Schematic diagram demonstrating the study design of in vivo experiments on Pde6b mut retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( B ) and the corresponding quantitative analysis of ONL thickness ( C ). MSCT mesenchymal stem cell transplantation, EXOT exosomal transplantation, GCL ganglion cell layer, ONH optic nerve head. Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for area under curve (AUC). N \u003d 3 per group. Representative scotopic electroretinography (ERG) waveforms ( D ) and the corresponding quantitative analyses of amplitude changes of a-wave ( E ) and b-wave ( F ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 3 per group. Representative photopic ERG waveforms ( G ) and the corresponding quantitative analysis of b-wave amplitude changes ( H ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 3 per group. I Representative immunofluorescent (IF) staining images of retinal tissues showing cone photoreceptor bodies (white) counterstained by Hoechst 33342 (blue). Scale bars \u003d 25 mum. Representative H\u0026E staining images of retinal tissues ( J ) and the corresponding quantitative analysis of ONL thickness ( K ). Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for AUC. N \u003d 3 per group. Represent','shortDescription':'Fig. 4 Intravitreal transplantation of mesenchymal stem cells (MSCs) and exosomes (EXO) ameliorates photoreceptor loss and retinal degeneration in the Phosphodiesterase 6b gene mutant ( Pde6b mut ) mouse model. A Schematic diagram demonstrating the study design of in vivo experiments on Pde6b mut retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( B ) and th... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig4_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'932899','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'77','description':'Fig. 2 Exosomes mediates therapeutic effects of mesenchymal stem cell transplantation (MSCT) on N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). Mice were injected with MNU with or without MSCT. GW4869, a neutral sphingomyelinase inhibitor for blocking exosome generation, which was used for MSC preconditioning before transplantation; GCL ganglion cell layer, INL inner nuclear layer, ONH optic nerve head. Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for area under curve (AUC). N \u003d 3 per group. Representative scotopic electroretinography (ERG) waveforms ( C ) and the corresponding quantitative analyses of amplitude changes of a-wave ( D ) and b-wave ( E ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. Representative photopic ERG waveforms ( F ) and the corresponding quantitative analysis of b-wave amplitude changes ( G ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. Representative H\u0026E staining images of retinal tissues ( H ) and the corresponding quantitative analysis of ONL thickness ( I ). Ctrl control, no MNU treatment, EXOT exosomal transplantation after MNU injection. Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for AUC. N \u003d 3 per group. Representative scotopic ERG waveforms ( J ) and the corresponding quantitat','shortDescription':'Fig. 2 Exosomes mediates therapeutic effects of mesenchymal stem cell transplantation (MSCT) on N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). Mice were injected with MNU with or without MSCT. ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig2_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'932880','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'78','description':'Fig. 1 Intravitreal transplantation of mesenchymal stem cells (MSCs) counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and alleviates retinal degeneration. A Schematic diagram demonstrating the study design of in vivo experiments on MNU-induced retinal degeneration. B Biodistribution of PKH26-labeled MSCs in the eye after intravitreal injection for 6 h. NC negative control, injection of MSCs without staining. Scale bar \u003d 2.5 mm. C Tracing of PKH26-labeled MSCs (red) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. MSCT mesenchymal stem cell transplantation after MNU injection, INL inner nuclear layer, ONL outer nuclear layer. Scale bar \u003d 50 mum. Representative hematoxylin and eosin (H\u0026E) staining images of retinal tissues ( D ) and the corresponding quantitative analysis of ONL thickness ( E ). Ctrl control, no MNU treatment, GCL ganglion cell layer, ONH optic nerve head. Scale bars \u003d 50 mum. * P \u003c 0.05 by the Kruskal-Wallis test for area under curve (AUC). N \u003d 3 per group. Representative scotopic electroretinography (ERG) waveforms ( F ) and the corresponding quantitative analyses of amplitude changes of a-wave ( G ) and b-wave ( H ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. Representative photopic ERG waveforms ( I ) and the corresponding quantitative analysis of b-wave amplitude changes ( J ). * P \u003c 0.05 by the Kruskal-Wallis tests. N \u003d 6 per group. K Representative immunofluorescen','shortDescription':'Fig. 1 Intravitreal transplantation of mesenchymal stem cells (MSCs) counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and alleviates retinal degeneration. A Schematic diagram demonstrating the study design of in vivo experiments on MNU-induced retinal degeneration. B Biodistribution of PKH26-labeled MSCs in the eye after intravitreal injection for 6 h. NC negative control, injecti... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15069_41418_2020_636_Fig1_HTML.jpg','benchSciPubmedId':'33082517'},{'sku':'12-0451-82','imageId':'839066','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12428_fcimb-10-557610-g0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12428_fcimb-10-557610-g0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12428_fcimb-10-557610-g0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12428_fcimb-10-557610-g0003.jpg?time\u003d20240507','sortOrder':'79','description':'Figure 3 DENV infection causes dynamic changes in immune cell populations in the brain. (A) A gating immunostaining strategy was used for the indicated cell populations. The percentage of (B) CD19-positive cells, (C) CD3-positive cells, (D) CD11c and MHC II-positive cells, (E) NK1.1-positive cells, and (F) CD14-positive cells in the immune cell populations of the mouse brains on the indicated day post-infection were shown. Each point represents a mouse sample. Data show the means +- SD of based on at least three mice. * p \u003c 0.05; *** p \u003c 0.001. ns: not significant.','shortDescription':'Figure 3 DENV infection causes dynamic changes in immune cell populations in the brain. (A) A gating immunostaining strategy was used for the indicated cell populations. The percentage of (B) CD19-positive cells, (C) CD3-positive cells, (D) CD11c and MHC II-positive cells, (E) NK1.1-positive cells, and (F) CD14-positive cells in the immune cell populations of the mouse brains on the indicated day post-infec... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 17, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cellular and infection microbiology','journalText':'Frontiers in cellular and infection microbiology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12428_fcimb-10-557610-g0003.jpg','benchSciPubmedId':'33072626'},{'sku':'12-0451-82','imageId':'850844','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8375_thnov10p11376g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8375_thnov10p11376g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8375_thnov10p11376g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8375_thnov10p11376g001.jpg?time\u003d20240507','sortOrder':'80','description':'Figure 1 Pre-depletion of microglia with PLX5622 reduces infiltrating cells and reactive oxygen species (ROS) production after SCI. ( A ) PLX5622 diet or vehicle chow were fed to animals three weeks before injury and remained for 2 days after injury. ( B ) Body weight was recorded both prior and after injury. All injured mice appeared significant loss of body weight. PLX had no effects on animal weight both prior and after injury. n \u003d 30 mice/group before SCI and 12 (Sham/Veh), 12 (Sham/PLX), 18 (SCI/Veh), and 18 (SCI/PLX) mice after SCI. ( C ) Food intake was recorded both prior and after injury. In all injured mice, food consumption decreased significantly. PLX had no effects on food consumption both prior and after injury. n \u003d 15 mice/group (Before injury) and 10 (Sham/Veh), 10 (Sham/PLX), 15 (SCI/Veh), and 15 (SCI/PLX) mice (After SCI). ( D ) Representative dot plots show the relative immune cell composition in the impact site of the spinal cord at two days post-injury. ( E ) The number of living CD45 int CD11b + Ly6C - microglia, CD45 hi CD11b + infiltrating myeloid cells, CD45 hi CD11b + Ly6C + Ly6G - monocytes, and CD45 hi CD11b + Ly6C + Ly6G + neutrophils are quantified. n \u003d 6 (Sham/Veh), 6 (Sham/PLX), 7 (SCI/Veh), and 7 (SCI/PLX). ( F ) Representative histograms show the relative production of ROS in microglia, bulk infiltrating myeloid cells, monocytes, and neutrophils as measured by DHR123. ( G ) The mean fluorescence intensity (MFI) of dihydrorhodamine 123 (DHR123','shortDescription':'Figure 1 Pre-depletion of microglia with PLX5622 reduces infiltrating cells and reactive oxygen species (ROS) production after SCI. ( A ) PLX5622 diet or vehicle chow were fed to animals three weeks before injury and remained for 2 days after injury. ( B ) Body weight was recorded both prior and after injury. All injured mice appeared significant loss of body weight. PLX had no effects on animal weight both... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Theranostics','journalText':'Theranostics 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8375_thnov10p11376g001.jpg','benchSciPubmedId':'33052221'},{'sku':'12-0451-82','imageId':'932664','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'81','description':'Fig. 3 Inhibition of CCR2/5 signaling reduces CNS macrophage infiltration without altering activation marker expression of infiltrating macrophages. a Mice received a pair-fed diet (PF) or chronic alcohol (EtOH), and some alcohol-fed mice received 6 weeks of daily preventive subcutaneous CVC injection (EtOH + 6wk CVC) or 3 weeks of daily CVC treatment (EtOH + 3wk CVC). PF and EtOH mice received daily vehicle control injections. b Representative flow cytometry plots of peripheral macrophages (CD11b + CD45 hi ) in EtOH, EtOH + 6wk CVC and EtOH + 3wk CVC-treated mice. c Quantification of infiltrating brain macrophages (CD11b + CD45 hi ) in pair-fed, alcohol-fed, and treatment groups. d Expression of various activation markers were measured by flow cytometry in CD11b + CD45 hi infiltrating macrophages including CD86, CD68, MHC-II, CD163, and CD206. Data are mean +- SEM, n \u003d 6-7 mice/group. * p \u003c 0.05 by one-way ANOVA','shortDescription':'Fig. 3 Inhibition of CCR2/5 signaling reduces CNS macrophage infiltration without altering activation marker expression of infiltrating macrophages. a Mice received a pair-fed diet (PF) or chronic alcohol (EtOH), and some alcohol-fed mice received 6 weeks of daily preventive subcutaneous CVC injection (EtOH + 6wk CVC) or 3 weeks of daily CVC treatment (EtOH + 3wk CVC). PF and EtOH mice received daily vehicl... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 9, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19137_12974_2020_1972_Fig3_HTML.jpg','benchSciPubmedId':'33036616'},{'sku':'12-0451-82','imageId':'932645','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'82','description':'Fig. 1 Alcohol induces infiltration of peripheral macrophages into the CNS. a Alcohol-fed mice received 5% (v/v) alcohol in Lieber-DeCarli liquid diet ad libitum (EtOH) for 6 weeks while pair-fed animals received a calorie-matched liquid diet (PF). b mRNA expression of Ccl2 , Ccr2 , and Ccr5 was measured from the hippocampus of PF and EtOH mice. c Brain immune cells from wild-type mice fed chronic alcohol (EtOH) or a pair-fed (PF) control diet were isolated and quantified by flow cytometry gating for live, single cells. Microglia (CD11b + CD45 lo ) were differentiated from peripheral macrophages (CD11b + CD45 hi ) based on surface marker staining and infiltrating macrophages in pair- vs alcohol-fed mice. d Quantification of microglia (CD11b + CD45 lo ) and peripheral macrophages (CD11b + CD45 hi ) in PF and EtOH mice. Data are mean +- SEM, n \u003d 4-7 mice/group. * p \u003c 0.05 by Student\u0027s t test','shortDescription':'Fig. 1 Alcohol induces infiltration of peripheral macrophages into the CNS. a Alcohol-fed mice received 5% (v/v) alcohol in Lieber-DeCarli liquid diet ad libitum (EtOH) for 6 weeks while pair-fed animals received a calorie-matched liquid diet (PF). b mRNA expression of Ccl2 , Ccr2 , and Ccr5 was measured from the hippocampus of PF and EtOH mice. c Brain immune cells from wild-type mice fed chronic alcohol (... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 9, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19137_12974_2020_1972_Fig1_HTML.jpg','benchSciPubmedId':'33036616'},{'sku':'12-0451-82','imageId':'932626','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'83','description':'Fig. 4 Knockout of RAB6 promoted the self-renewal and proliferation of AEC2s. a The enriched AEC2 cell population was isolated by selection of the CD24 - SFTPC + subset from epithelial cell populations (EpCAM + CD31 - CD34 - CD45 - ) in lung tissues by FACS. b The localization and expression of RAB6 and SFTPC proteins in WT and RAB6 -/- AEC2 cells were detected by immunofluorescence (Green, RAB6; red, SFTPC; blue, DAPI) (Representative immunofluorescence images are shown, n \u003d 3). c WT and RAB6 -/- AEC2 cells were exposed to PM2.5 (100 mug/ml) or saline for 48 h. The apoptosis of AEC2 cells was determined by FACS (Representative FACS images are shown, n \u003d 3). d Statistical analysis of apoptosis rate. e The colony forming efficiency (CFE) of WT and RAB6 -/- AEC2 cells was examined by plate colony formation assay (Representative images are shown, n \u003d 3). f Statistical analysis of CFE (represented by colony numbers). g Self-renewal (spherication ability) of WT and RAB6 -/- AEC2 cells exposed to PM2.5 or saline was detected by 3D culture (Representative images are shown, n \u003d 3). h - j The relative RNA expression of SOX2 ( h ), OCT4 ( i ), and NANOG ( j ) was measured by qRT-PCR. ( n \u003d 3; unpaired two-tailed t test. ** P \u003c 0.01; *** P \u003c 0.001. Bar graphs represent the mean +- SEM for d , f , h - j ).','shortDescription':'Fig. 4 Knockout of RAB6 promoted the self-renewal and proliferation of AEC2s. a The enriched AEC2 cell population was isolated by selection of the CD24 - SFTPC + subset from epithelial cell populations (EpCAM + CD31 - CD34 - CD45 - ) in lung tissues by FACS. b The localization and expression of RAB6 and SFTPC proteins in WT and RAB6 -/- AEC2 cells were detected by immunofluorescence (Green, RAB6; red, SFTPC... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Oct 4, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15099_41419_2020_3027_Fig4_HTML.jpg','benchSciPubmedId':'33012781'},{'sku':'12-0451-82','imageId':'851620','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9817_jciinsight-5-136773-g165.jpg?time\u003d20240507','sortOrder':'84','description':'Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a GCT sample. ( B-D ) Representative staining with CD11b, HLA-DR, CD11c, Lineage, CD14, CD15, and CD33 used to identify the myeloid populations in a GCT sample. Tumor-associated macrophages (TAMs)/monocytes were separated from DC based on CD14 expression ( C ). Myeloid-derived suppressor cells (MDSC) were separated as eMDSC based on Lineage, HLA-DR, CD11b, and CD33 markers ( B ), whereas PMN-MDSC were characterized as CD15 + CD14 - CD11b + ( D ). Proportions of tumor-infiltrating immune cells in GCT were quantified as percentage of total cell suspension. ( E ) Percentages of CD4 + T cells, CD8 + T cells, and Tregs compared with total tumor cell suspension. ( F ) Comparison of PD1-expressing T cells in the GCT vs. PBMCs. ( G ) CD8 + T cells/Tregs ratio in GCT vs. PBMCs. ( H ) Percentage of TAMs/monocytes, DC, PMN-MDSC, and eMDSC of total tumor cell suspension. Mean +- SEM is shown. Each dot represents a patient ( n \u003d 7) or healthy control PBMCs ( n \u003d 3).','shortDescription':'Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 20, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9817_jciinsight-5-136773-g165.jpg','benchSciPubmedId':'32814714'},{'sku':'12-0451-82','imageId':'855260','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9903_jciinsight-5-137713-g026.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9903_jciinsight-5-137713-g026.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9903_jciinsight-5-137713-g026.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9903_jciinsight-5-137713-g026.jpg?time\u003d20240507','sortOrder':'85','description':'Figure 3 Resolvin D1 limits inflammation and expedites its resolution following muscle injury. ( A ) C57BL/6 mice received bilateral intramuscular injection of the TA muscle with 50 muL of 1.2% BaCl 2 to induce myofiber injury. Mice were treated with RvD1 (100 ng) or vehicle (0.1% ethanol) via intraperitoneal (IP) injection approximately 5 minutes before muscle injury. TA cross sections were stained for PMNs (Ly6G) or monocytes/macrophages (CD68). Cell nuclei and the basal lamina were counterstained with DAPI and laminin antibody, respectively. Scale bars: 200 mum. ( B ) Whole-muscle mRNA expression of immune cell markers and inflammatory cytokines at 24 hours postinjury as determined by real-time quantitative reverse transcription PCR (RT-qPCR). Gene expression was normalized to Actb . ( C ) Mice were treated for 72 hours with daily IP injection of RvD1 (100 ng) or vehicle (0.1% ethanol) following muscle injury, and TA cross sections were stained for PMNs (Ly6G) or macrophages (CD68) at day 3 postinjury. Representative images show examples of regions of muscle not yet infiltrated by macrophages where lingering PMNs remained (top) and macrophage-rich regions largely devoid of PMNs (bottom). ( D ) Single cells isolated from pooled left and right TA muscles at day 3 postinjury were analyzed by flow cytometry for CD45-PE and Ly6G-FITC. Bars show the mean +- SEM of 5-10 mice per group with dots representing data from each mouse. P values were determined 2-tailed unpaired t tests.','shortDescription':'Figure 3 Resolvin D1 limits inflammation and expedites its resolution following muscle injury. ( A ) C57BL/6 mice received bilateral intramuscular injection of the TA muscle with 50 muL of 1.2% BaCl 2 to induce myofiber injury. Mice were treated with RvD1 (100 ng) or vehicle (0.1% ethanol) via intraperitoneal (IP) injection approximately 5 minutes before muscle injury. TA cross sections were stained for PMN... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Sep 17, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9903_jciinsight-5-137713-g026.jpg','benchSciPubmedId':'32750044'},{'sku':'12-0451-82','imageId':'853220','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9852_cancers-12-02083-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9852_cancers-12-02083-g004.jpg?time\u003d20240507','sortOrder':'86','description':'Figure 4 Population of CD11b + myeloid progenitor cells differentiate into SMA + stromal cells within tumors and in vitro. ( A ) Representative image of red fluorescent protein (RFP) + stromal cells in tumor from CCR2-RFP heterozygous SCID mouse. ( B ) RFP + SMA + double positive cells within tumor stroma. ( C ) CD11b + SMA + double positive cells within tumor stroma. ( D ) CD45 + CD11b + CD34+ myeloid progenitor cells in the mammary gland at 1.5 ( n \u003d 5 empty vector (EV), 7 CCL2) and 2.5 weeks ( n \u003d 5 EV, 7 CCL2) post-transplantation were quantified by flow cytometry. ( E ) CD45 + CD11b + CD34 + myeloid progenitor cells in the bone marrow at 1.5 weeks ( n \u003d 6 EV, 7 CCL2) and 2.5 weeks ( n \u003d 3 mice/group) post-transplantation were quantified by flow cytometry. ( F ) Representative brightfield image of colony formed by CD45 + CD11b + CD34 + myeloid progenitor cells isolated using fluorescence-activated cell sorting (FACS). ( G ) Colonies in culture co-stained with SMA and collagen I. Statistical differences determined by Mann-Whitney U test. Magnification bars \u003d 50 um.','shortDescription':'Figure 4 Population of CD11b + myeloid progenitor cells differentiate into SMA + stromal cells within tumors and in vitro. ( A ) Representative image of red fluorescent protein (RFP) + stromal cells in tumor from CCR2-RFP heterozygous SCID mouse. ( B ) RFP + SMA + double positive cells within tumor stroma. ( C ) CD11b + SMA + double positive cells within tumor stroma. ( D ) CD45 + CD11b + CD34+ myeloid prog... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9852_cancers-12-02083-g004.jpg','benchSciPubmedId':'32731354'},{'sku':'12-0451-82','imageId':'853181','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9852_cancers-12-02083-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9852_cancers-12-02083-g002.jpg?time\u003d20240507','sortOrder':'87','description':'Figure 2 Stromal CCL2 overexpression in mouse mammary glands leads to time-dependent changes in the developing tumor microenvironment. ( A ) Representative H\u0026E images of oncogenic epithelial cell growth at 1.5 and 2.5 weeks post-transplantation. ( B ) Percent area of F4/80 + macrophages in developing tumors at 1.5 and 2.5 weeks post-transplantation ( n \u003d 4 tumors/group; Student\u0027s t -test). ( C ) CD45 + CD11b + monocytes/macrophages in the mammary gland at 1.5 and 2.5 weeks post-transplantation were quantified by flow cytometry ( n \u003d 5 EV, 7 CCL2, Mann-Whitney U test). ( D ) Percent area of SMA + cells in developing tumors at 1.5 and 2.5 weeks post-transplantation ( n \u003d 4 tumors/group; Student\u0027s t -test). Magnification bars \u003d 50 um.','shortDescription':'Figure 2 Stromal CCL2 overexpression in mouse mammary glands leads to time-dependent changes in the developing tumor microenvironment. ( A ) Representative H\u0026E images of oncogenic epithelial cell growth at 1.5 and 2.5 weeks post-transplantation. ( B ) Percent area of F4/80 + macrophages in developing tumors at 1.5 and 2.5 weeks post-transplantation ( n \u003d 4 tumors/group; Student\u0027s t -test). ( C ) CD45 + CD11... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9852_cancers-12-02083-g002.jpg','benchSciPubmedId':'32731354'},{'sku':'12-0451-82','imageId':'855238','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'88','description':'Fig. 1 DETC development requires Skint2 and Skint1 which form heteromers. a qPCR analysis for Skint1 and Skint2 message in adult mouse ear epidermis normalised to Ppia . Control , n \u003d 8, Skint2 Delta/Delta , n \u003d 8. Data are mean +- SD of a representative experiment of three independent experiments. b Analysis of E16.5 thymocytes in WT, Skint2 Delta/Delta and Skint1 Delta/Delta animals, gated on live gammadelta T cells (top panel). Thymic gammadelta cells (gate top row) were assessed for CD45RB, CD122, CD24 and CD62L and expression of the Vgamma5 TCR. Left panel: WT vs. Skint2 Delta/Delta , right panel: WT vs. Skint1 Delta/Delta . c Quantification of cell populations in quadrants Q1 to Q4 as indicated in ( b ), normalised to mean of wt \u003d 1 for each quadrant, mean +- SD. WT n \u003d 20; Skint2 Delta/Delta n \u003d 5; Skint1 Delta/Delta n \u003d 8 (two-tailed Man-Whitney analysis). d FACS analysis of ear epidermis in control ( Skint2 Delta/+ ) and Skint2 Delta/Delta mice. CD45 + , TCRgammadelta + cells (gate left panel) were stained for presence of Vgamma5Vdelta1 + DETC (stained by Vgamma5 and 17D1 antibody, right panel). e Microscopy images of adult mouse ear epidermal sheets in control and Skint2 Delta/Delta mice. Comparison of DETC stained for CD45 (top: blue) and Vgamma5 + (middle: green) gammadelta-TCR(GL3 + ) cells (bottom: red). Scale bar 50 um. f Quantification of DETC and Langerhans cell numbers from microscopy images, n \u003d 15 for each genotype (data are from three independent experime','shortDescription':'Fig. 1 DETC development requires Skint2 and Skint1 which form heteromers. a qPCR analysis for Skint1 and Skint2 message in adult mouse ear epidermis normalised to Ppia . Control , n \u003d 8, Skint2 Delta/Delta , n \u003d 8. Data are mean +- SD of a representative experiment of three independent experiments. b Analysis of E16.5 thymocytes in WT, Skint2 Delta/Delta and Skint1 Delta/Delta animals, gated on live gammade... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jul 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9902_41467_2020_17557_Fig1_HTML.jpg','benchSciPubmedId':'32724083'},{'sku':'12-0451-82','imageId':'932797','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time\u003d20240507','sortOrder':'89','description':'Supplementary Figure S2','shortDescription':'Supplementary Figure S2','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15001_41418_2020_590_MOESM3_ESM.jpg','benchSciPubmedId':'32694652'},{'sku':'12-0451-82','imageId':'932607','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15169_gr4_lrg.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15169_gr4_lrg.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15169_gr4_lrg.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15169_gr4_lrg.jpg?time\u003d20240507','sortOrder':'90','description':'Figure 4 IL-31 in Wounds Was Mostly from Dermal cDC2s (A) Macrophages (CD45 + CD3 - CD11c - CD64 + CD11b + F4/80 + ), LCs (CD45 + CD3 - CD11c + CD326 + ), dermal cDC2s (CD45 + CD3 - CD11c + CD326 - CD64 - CD11b + MHC II + ), and dermal cDC1s (CD3 - CD11c + CD326 - CD64 - CD11b - MHC II + ) were sorted from fifth-day wounds, and Il31 expression was determined by real-time PCR. Data were from 2-3 independent experiments with 2 samples each time, and each sample was pooled from 4 wounds in 2 mice. Data were analyzed with one-way ANOVA for comparisons. Bars represent means +- SEM. **** p \u003c 0.0001. (B) Il31 gene expression in dermal cDC2 from fifth-day wounds was compared with cDC2s from normal skin by real-time PCR. Data are from 3 independent experiments with 2 samples each time, and each sample was pooled from 4 wounds in 2 mice. Data were analyzed with Student\u0027s t test for comparisons. Bars represent means +- SEM. **** p \u003c 0.0001. (C-E) Flow cytometer analysis showed that the frequency (C and D) and total numbers of dermal cDC2s (CD45 + CD11c + CD64 - CD11b + MHC II + CD326 - ) (E) were increased in fifth-day wound skin tissues compared with normal skin. In (D) and (E), each circle represents one mouse. Data were from 3 independent experiments (n \u003d 5-6), and Student\u0027s t test was used. Bars represent means +- SEM. **** p \u003c 0.0001.','shortDescription':'Figure 4 IL-31 in Wounds Was Mostly from Dermal cDC2s (A) Macrophages (CD45 + CD3 - CD11c - CD64 + CD11b + F4/80 + ), LCs (CD45 + CD3 - CD11c + CD326 + ), dermal cDC2s (CD45 + CD3 - CD11c + CD326 - CD64 - CD11b + MHC II + ), and dermal cDC1s (CD3 - CD11c + CD326 - CD64 - CD11b - MHC II + ) were sorted from fifth-day wounds, and Il31 expression was determined by real-time PCR. Data were from 2-3 independent ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 18, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Immunity','journalText':'Immunity 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15169_gr4_lrg.jpg','benchSciPubmedId':'32673566'},{'sku':'12-0451-82','imageId':'932588','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'91','description':'Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone marrow and culture for an equal number of passages, me v /me v and WT MSCs were harvested and analyzed for the indicated markers by immunofluorescence staining and flow cytometry. The experiments were repeated at least three times. Error bars represent +- SEM (n \u003d 3), ns, not significant','shortDescription':'Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 14, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell \u0026 bioscience','journalText':'Cell \u0026 bioscience 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15132_13578_2020_428_Fig1_HTML.jpg','benchSciPubmedId':'32467752'},{'sku':'12-0451-82','imageId':'843401','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'92','description':'Fig. 2 CK2 is required for bone formation during skeletal development. a Csnk2b mRNA levels in the hindlimbs (femur and tibia) of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. ( n \u003d 4). b , c Alizarin red/alcian blue staining of skeletal preparations of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. Scale bar, 1 mm. Safranin O staining of humeri ( d ) and femurs ( e ) of P0 Csnk2b fl/fl and Csnk2b Prx1 pups. Scale bars, 250 mum (left) and 50 mum (right, enlarged one). f , g Csnk2b mRNA levels in SSCs (CD45 - Ter119 - Tie2 - alphaV-Int + Thy1 - 6C3 - CD105 - CD200 + ) isolated from E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos ( f ). Frequency of SSCs within the population of total skeletal cells (CD45 - Ter119 - Tie2 - alphaV-Int + ) ( g ). f n \u003d 4; g, n \u003d 6 ( Csnk2b fl/fl ) or 5 ( Csnk2b Prx1 )). h - j SSCs (CD45 - Ter119 - Tie2 - alphaV-Int + Thy1 - 6C3 - CD105 - CD200 + ) isolated from E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryonic limbs were transplanted beneath the kidney capsule. MicroCT analysis shows 3D-reconstruction ( h ) and quantification ( i ) of bone mass in the kidney capsule. BV bone volume. Histologic sections of kidney capsule were stained with H\u0026E ( j , left) or Von Kossa ( j , right). The arrow highlights the ectopic bone. Scale bars, 200 mum ( h ); 100 mum ( j ). i n \u003d 7 or 14. Data are representative of three ( a - e , h , j ) independent experiments or are pooled from two experiments ( f , g , i ). A two-tailed unpaired Student\u0027\u0027s t test for comparing two groups','shortDescription':'Fig. 2 CK2 is required for bone formation during skeletal development. a Csnk2b mRNA levels in the hindlimbs (femur and tibia) of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. ( n \u003d 4). b , c Alizarin red/alcian blue staining of skeletal preparations of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. Scale bar, 1 mm. Safranin O staining of humeri ( d ) and femurs ( e ) of P0 Csnk2b fl/fl and Csnk2b Prx1 pups. Sca... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'May 8, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12872_41467_2020_16038_Fig2_HTML.jpg','benchSciPubmedId':'32385263'},{'sku':'12-0451-82','imageId':'841382','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'93','description':'Figure 6 Ly6c Lo non-classical monocytes promote resolution of RRV-mediated periportal inflammation. ( a ) Dosage schedule illustrating regimen used to deplete Ly6c Hi classical monocytes (anti-Ccr2) and neutrophils (anti-Ly6g), and to inhibit Ly6c Lo non-classical monocytes (Cx3cr1 small molecular inhibitor, AZD8797) after inducing RRV-mediated liver injury in neonatal pups. ( b-d ) Depletion via anti-Ccr2 led to a 76% reduction of Ly6c Hi classical monocytes in the Cd45 + leukocyte compartment, which did not affect the proportion of Ly6c Lo non-classical monocytes (RRV n \u003d 11, RRV anti-Ccr2 n \u003d 10) and a 95% reduction of the absolute number of Ly6c Hi classical monocytes expected in a P7 liver. This led to a statistically significant increase in the ratio of Ly6c Lo : Ly6c Hi monocytes (p-value 0.026 (*)). ( e-g ) Depletion of neutrophils alone (p-value E : \u003c0.0001 (****), p-value F : 0.048 (*)) led to an expansion of Ly6c Lo non-classical monocytes, (p-value F : 0.04 (*)), but did not change the ratio of Ly6c Lo : Ly6c Hi monocytes (( d ) RRV n \u003d 14, RRV anti-Ly6g n \u003d 7, ( e ) RRV n \u003d 4, RRV anti-Ly6g n \u003d 4). ( h-j ) Depleting both Ly6c Hi classical monocytes (p-value: 0.0207 (*)) and neutrophils (p-value: \u003c0.0001 (****)) (Double Depletion, DD) led to further expansion of Ly6c Lo non-classical monocytes (p-value: \u003c0.0001 (****)) (n \u003d 4) and a significantly higher survival rate when compared to RRV alone (p-value 0.0002) or RRV plus single depletion (RRV n \u003d 49, RRV Ly6c Hi','shortDescription':'Figure 6 Ly6c Lo non-classical monocytes promote resolution of RRV-mediated periportal inflammation. ( a ) Dosage schedule illustrating regimen used to deplete Ly6c Hi classical monocytes (anti-Ccr2) and neutrophils (anti-Ly6g), and to inhibit Ly6c Lo non-classical monocytes (Cx3cr1 small molecular inhibitor, AZD8797) after inducing RRV-mediated liver injury in neonatal pups. ( b-d ) Depletion via anti-Ccr2... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12622_41598_2020_64158_Fig6_HTML.jpg','benchSciPubmedId':'32346042'},{'sku':'12-0451-82','imageId':'841325','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'94','description':'Figure 3 Physiological abundance of Ly6c Lo non-classical monocytes compared to Ly6c Hi classical monocytes in the late gestation fetal liver. ( a ) Ly6c Lo monocytes, Ly6c Hi monocytes, and other leukocyte populations were identified by flow cytometry. ( b,c ) The overall proportion of Cd45 + leukocytes is relatively low in the late gestational fetal liver (E17.5, n \u003d 11), then increases by day of birth (P0, n \u003d 9), and plateaus (P3, n \u003d 6; P7, n \u003d 9; P10, n \u003d 6; P14, n \u003d 7), whereas the proportion in the spleen stays relatively stable (P0, n \u003d 6; P3, n \u003d 6; P7, n \u003d 9; P10, n \u003d 6; P14, n \u003d 7. ( d,e ) Cd11b + monocytes were identified and are at their highest abundance of the Cd45 + leukocyte compartment in the late gestational liver (E17.5, n \u003d 11). They then decrease at birth (P0, n \u003d 6), rise again to a level that is between the two earlier time points (P3, n \u003d 6; P7, n \u003d 9), and then decrease to day of birth levels (P10, n \u003d 6; P14, n \u003d 4). In the spleen, Ly6c Lo non-classical monocytes remained low at birth and peaked at P7. (f-g) There is a physiological abundance of Ly6c Lo non-classical monocytes compared to Ly6c Hi classical monocytes at E17.5 in the liver that is not observed in the spleen (p-value % : \u003c0.0001 (****), p-value # : 0.0007 (***)). Data represent mean +/- SEM.','shortDescription':'Figure 3 Physiological abundance of Ly6c Lo non-classical monocytes compared to Ly6c Hi classical monocytes in the late gestation fetal liver. ( a ) Ly6c Lo monocytes, Ly6c Hi monocytes, and other leukocyte populations were identified by flow cytometry. ( b,c ) The overall proportion of Cd45 + leukocytes is relatively low in the late gestational fetal liver (E17.5, n \u003d 11), then increases by day of birth (P... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12622_41598_2020_64158_Fig3_HTML.jpg','benchSciPubmedId':'32346042'},{'sku':'12-0451-82','imageId':'932550','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'95','description':'Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n \u003d 9), G007-LK diet ( n \u003d 9), anti-PD-1 ( n \u003d 10), and anti-PD-1/G007-LK ( n \u003d 10). Mann-Whitney rank sum tests are indicated by + ( P \u003c 0.05) and ++ ( P \u003c 0.01). For a - e Mean values are indicated by grey lines. b Tumor end volumes of B16-F10-challenged (s.c.) C57BL/6 Rag2 -/- mice treated for 12 days with control diet ( n \u003d 11) compared to combined anti-PD-1/G007-LK treatment ( n \u003d 10). n.s. not sig n ificant. c B16-F10 tumor (s.c.) end volume reduction upon anti-PD-1/G007-LK treatment in C57BL/6 N mice from day 10 through day 21. Control diet ( n \u003d 11), anti-IgG1 isotype control ( n \u003d 12), anti-IgG2 isotype control ( n \u003d 10), anti-CD8alpha ( n \u003d 10), anti-IFNgamma ( n \u003d 9), anti-PD-1/G007-LK ( n \u003d 10), anti-PD-1/G007-LK /anti-CD8alpha ( n \u003d 9), and anti-PD-1/G007-LK /anti-IFNgamma ( n \u003d 9). One-tailed t -tests are indicated by *( P \u003c\u003d 0.05) while one-tailed Mann-Whitney rank sum test is indicated by + ( P \u003c 0.05). d Flow cytometry analysis of CD8 + and CD4 + T cells (shown as % of CD45 + T cells) from single-cell suspensions of comparable-sized tumors collected from B16-F10-challenged (s.c.) C57BL/6 N m','shortDescription':'Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n \u003d 9), G007-LK diet ( n \u003d 9), anti... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 24, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Communications biology','journalText':'Communications biology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12503_42003_2020_916_Fig5_HTML.jpg','benchSciPubmedId':'32332858'},{'sku':'12-0451-82','imageId':'843381','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'96','description':'Fig. 5 Boc2-treatment reduces plaque load and phagocytosis rate of Abeta in APP/PS1 double-transgenic mice. Coronal brain sections of 29-week-old APP/PS1 double-transgenic mice with or without Boc2 treatment stained with anti-Beta-Amyloid 1-42 were used for the determination of plaque load. a Analysis of the total hippocampal Abeta plaque load (number/mm 2 ). b The average number of plaques/mm 2 grouped in four different size categories (\u003c 125 mum 2 , 125-250 mum 2 , 250-500 mum 2 , and \u003e 500 mum 2 ). Plaque numbers were analyzed in anti-Beta-Amyloid 1-42 processed sections. c Abeta phagocytosis rate (in %), analyzed by flow cytometry of microglia isolated from APP/PS1 double-transgenic mice with or without Boc2 treatment 3 h after intraperitoneal injection of methoxy-XO4. d Representative images of hippocampal plaques analysis demonstrating the evaluation process with ImageJ. Scale bar: 250 mum. e Average microglial cell area (mum 2 ) around the Abeta plaques, visualized by anti-IBA-1 stains in the hippocampus of APP/PS1 double-transgenic mice with or without Boc2 or fMLF treatment. f Representative image of a plaque stained with anti-IBA-1 (red) and anti-beta-Amyloid 1-42 (blue). Statistical significances were determined using Mann-Whitney U test ( a ), Kruskal-Wallis followed Dunn test ( b ), two-way ANOVA with turkey test ( d ), or t-test ( f ). Data represent mean + SEM; n \u003e\u003d 7; * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001 as indicated','shortDescription':'Fig. 5 Boc2-treatment reduces plaque load and phagocytosis rate of Abeta in APP/PS1 double-transgenic mice. Coronal brain sections of 29-week-old APP/PS1 double-transgenic mice with or without Boc2 treatment stained with anti-Beta-Amyloid 1-42 were used for the determination of plaque load. a Analysis of the total hippocampal Abeta plaque load (number/mm 2 ). b The average number of plaques/mm 2 grouped in ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Apr 24, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of neuroinflammation','journalText':'Journal of neuroinflammation 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12871_12974_2020_1816_Fig5_HTML.jpg','benchSciPubmedId':'32331524'},{'sku':'12-0451-82','imageId':'735679','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7910_ijbsv16p1526g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7910_ijbsv16p1526g002.jpg?time\u003d20240507','sortOrder':'97','description':'Figure 2 Combination of GW9662 and alphaPD-L1 elicits more tumor-infiltrating T cells and anti-tumor cytokines in CD8 + TILs versus single agents. (A) Percentage of CD3 + T lymphocytes of live CD45 + cells from tumors isolated 13 days post tumor injection in female mice following various treatments as indicated. (B) Percentage of CD8 + T cells percentage (of CD45 + CD3 + cells) in alphaPD-L1 and GW9662 combination treatment group. (C) Percentage of CD4 + T cells (of CD45 + CD3 + cells). (D) Representative flow cytometry of the IFN-gamma and TNF-alpha staining in CD45 + CD3 + CD8 + TILs. (E) IFN-gamma + , (f) TNF-alpha + and (G) dual positive IFN-gamma + TNF-alpha + percentage gated on CD45 + CD3 + CD8 + T cells. (H) Mean fluorescent intensity (MFI) of IFN-gamma, an indicator of cytokine production per cell in various treatment groups. N\u003d4 mice per group. VEH: DMSO+alphaIgG/. alphaPD-L1: DMSO+alphaPD-L1. GW: GW9662+alphaIgG. alphaPD-L1+GW: alphaPD-L1+GW9662. Data represent mean +- SD. P values as indicated.','shortDescription':'Figure 2 Combination of GW9662 and alphaPD-L1 elicits more tumor-infiltrating T cells and anti-tumor cytokines in CD8 + TILs versus single agents. (A) Percentage of CD3 + T lymphocytes of live CD45 + cells from tumors isolated 13 days post tumor injection in female mice following various treatments as indicated. (B) Percentage of CD8 + T cells percentage (of CD45 + CD3 + cells) in alphaPD-L1 and ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 23, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of biological sciences','journalText':'International journal of biological sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7910_ijbsv16p1526g002.jpg','benchSciPubmedId':'32226299'},{'sku':'12-0451-82','imageId':'850146','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7910_ijbsv16p1526g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7910_ijbsv16p1526g003.jpg?time\u003d20240507','sortOrder':'98','description':'Figure 3 Male hosts are refractory to the GW9662 + alphaPD-L1 combination treatment in a castration-independent manner. (A) B16 tumor growth curves in normal male mice (n\u003d5 per group). (B-D) B16 tumor growth in age-matched female (n\u003d10 per group) (b), sham surgery-treated male (n\u003d9 for VEH, n\u003d8 for alphaPD-L1+GW) (c) and castrated male mice (n\u003d9 for VEH, n\u003d10 for alphaPD-L1+GW) (d). VEH: DMSO+ alphaIgG. alphaPD-L1: DMSO+alphaPD-L1. GW: GW9662+alphaIgG. alphaPD-L1+GW: alphaPD-L1+GW9662. (E-G) TIL analysis for B16 tumors in age-matched female, sham-treated male and castrated male mice. Percentage of (e) CD3 + (of CD45 + ), (f) CD8 + (of CD45 + CD3 + ), (g) T cell stem cell marker TCF-1 + (of CD45 + CD3 + CD8 + ). N\u003d4 mice per group for panel e-g. (F) Female. Sham M: sham surgery-treated male. Castrated M: castrated male. Data represent mean +- SD. P values as indicated.','shortDescription':'Figure 3 Male hosts are refractory to the GW9662 + alphaPD-L1 combination treatment in a castration-independent manner. (A) B16 tumor growth curves in normal male mice (n\u003d5 per group). (B-D) B16 tumor growth in age-matched female (n\u003d10 per group) (b), sham surgery-treated male (n\u003d9 for VEH, n\u003d8 for alphaPD-L1+GW) (c) and castrated male mice (n\u003d9 for VEH, n\u003d10 for alphaPD-L1+GW) (d). VEH: DMSO+ alphaIgG. alp... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'Aug 23, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of biological sciences','journalText':'International journal of biological sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7910_ijbsv16p1526g003.jpg','benchSciPubmedId':'32226299'},{'sku':'12-0451-82','imageId':'932531','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','sortOrder':'99','description':'Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks of culture in osteogenic induction medium, the cells were stained with alizarin red. Mineralized nodules are shown. (I) Following 3 weeks of culture in adipogenic induction medium, the cells were stained with Oil Red O. Lipid globules are shown (black arrow). hPDLSCs, human periodontal ligament stem cells; PE, phycoerythrin.','shortDescription':'Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks o... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody in Flow Cytometry (Flow)','title':'CD45 Antibody (12-0451-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19108_MMR-21-05-2085-g00.jpg','benchSciPubmedId':'32186753'}],'Advanced Verification':[{'sku':'12-0451-82','imageId':'863160','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time\u003d20240507','sortOrder':'2','description':'Figure 1. PLX3397 treatment eliminated microglia and exacerbated stroke severity in MCAO mice. Wild type C57BL/6 mice were fed PLX3397 or control chow diet for 21 days prior to sham or MCAO surgeries. After surgeries, these mice continued to receive PLX3397 or control diet until they were sacrificed. At day 1 or day 3 after 60 min MCAO and reperfusion, mice were subjected to neurological assessment, MRI, flow cytometry, and pathology staining. (a) Schematic showing the experimental design. (b) Representative flow cytometry plots show the gating strategy of CD11b + CD45 int microglial cell population. Bar graphs summarize the results from sham or MCAO mice receiving the indicated treatment at day 1 and day 3 after MCAO reperfusion. (c) Bar graphs illustrate the indicated neurological assessments of sham and MCAO mice receiving PLX3397 or control diet at day 1 or day 3 after reperfusion. (d) Representative MRI images show infarct area (outlined in red) in MCAO mice receiving PLX3397 or control diet after MCAO reperfusion. Bar graphs show the infarct volume of MCAO mice receiving PLX3397 or control diet at indicated time points. n \u003d 15 mice per group. Error bars represent SD; * P \u003c 0.05; ** P \u003c 0.01. {TM}','shortDescription':'Figure 1. PLX3397 treatment eliminated microglia and exacerbated stroke severity in MCAO mice. Wild type C57BL/6 mice were fed PLX3397 or control chow diet for 21 days prior to sham or MCAO surgeries. After surgeries, these mice continued to receive PLX3397 or control diet until they were sacrificed. At day 1 or day 3 after 60 min MCAO and reperfusion, mice were subjected to neurological assessment, MRI, fl... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45 Antibody','title':'CD45 Antibody (12-0451-82)','appAbv':'TM','appName':'Cell treatment','type':'Advanced Verification','journalText':'','sourceType':'7','benchsci':true,'imageName':'tfs_3583_10.1177_0271678X17694185-fig1.jpg','benchSciPubmedId':'0'}]}" image-displayed-id="'710847'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'12-0451-82'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing Data (1) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Published Figures"> <a class="tab-text"> Published Figures (97) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Advanced Verification"> <a class="tab-text"> Advanced Verification (1) </a> </li> </ul> <div gallery-flt class="gal-flt" is-with-abbr="true" enable-mobile-flt="true" mobile-result-count="true" filter-data="$ctrl.applicationsList" advanced-filter-data="$ctrl.advancedApplicationsList" filter-text="Application" event-name="{{$ctrl.fltAppEvent}}"> </div> </div> <div class="cntnt" ng-swipe-right="$ctrl.clickLeftArrow()" ng-swipe-left="$ctrl.clickRightArrow()"> <div class="nav-arrow" ng-if="!$ctrl.isMobileSmallTabletScreen()" onclick="window.THERMO_FISHER.inp.onClickOfLeftArrow(event, this)"> <div tabindex="0" class="gallery-left-arrows icon-gallery-arrow-left" > </div> </div> <div class="media-text"> <div class="media-display-mobile" ng-if="$ctrl.isMobileSmallTabletScreen()"> <div class="nav-arrow" onclick="window.THERMO_FISHER.inp.onClickOfLeftArrow(event, this)"> <div tabindex="0" class="gallery-left-arrows icon-gallery-arrow-left" > </div> </div> <div class="media-display"> <img id="media-image" class="image" ng-show="!$ctrl.isVideo" src="https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody in Flow Cytometry (Flow)" longdesc="https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507?time=20240507" onerror="javascript:imageErrorHandler.call(this, event);" > <div class="hover-text" ng-show="!$ctrl.isVideo"> <a href="javascript:return false;" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)" aria-label="image-link"> <div class="rectangle"> <div class="expand-logo-rightcorner"> <?xml version="1.0" encoding="utf-8"?>  <svg width="19px" height="19px" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" d="M0.1,1.3c0,1.9,0,4,0,6h2.2c0-1,0-1.9,0-2.9c0-0.2,0-0.4,0-0.6C2.4,3.9,2.5,4,2.5,4.1 c1.3,1.3,2.7,2.7,4,3.9l1.6-1.5c-1.3-1.3-2.7-2.7-4-4C4,2.4,3.9,2.3,3.8,2.2c0.2,0,0.3,0,0.4,0c1,0,2.1,0,3.1,0V0 C5,0,2.6,0,0.3,0C0.2,0,0.1,0,0,0C0,0.5,0.1,0.9,0.1,1.3"/> <path id="Fill-10" class="st0" d="M20.7,0.1c-1.9,0-4,0-6,0v2.1c1,0,1.9,0,2.9,0c0.2,0,0.4,0,0.6,0C18,2.4,18,2.5,17.9,2.6 c-1.3,1.3-2.7,2.6-3.9,3.9L15.5,8c1.3-1.3,2.7-2.6,4-4c0.1-0.1,0.2-0.1,0.3-0.2c0,0.2,0,0.3,0,0.4c0,1,0,2,0,3.1H22 c0-2.3,0-4.7,0.1-6.9c0-0.1,0-0.2,0-0.3C21.5,0.1,21.1,0.1,20.7,0.1"/> </g> </g> </g> </g> </g> </g> </g> </svg> </div> </div> </a> </div> </div> <div class="nav-arrow" onclick="window.THERMO_FISHER.inp.onClickOfRightArrow(event, this)"> <div tabindex="0" class="gallery-right-arrows icon-gallery-arrow-right"> </div> </div> </div> <div class="media-display" ng-if="!$ctrl.isMobileSmallTabletScreen()"> <img id="media-image" class="image" ng-show="!$ctrl.isVideo" src="https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody in Flow Cytometry (Flow)" longdesc="https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507?time=20240507" onerror="javascript:imageErrorHandler.call(this, event);" > <div class="hover-text" ng-show="!$ctrl.isVideo"> <a href="javascript:return false;" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)" aria-label="image-link"> <div class="rectangle"> <div class="expand-logo-rightcorner"> <?xml version="1.0" encoding="utf-8"?>  <svg width="19px" height="19px" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" d="M0.1,1.3c0,1.9,0,4,0,6h2.2c0-1,0-1.9,0-2.9c0-0.2,0-0.4,0-0.6C2.4,3.9,2.5,4,2.5,4.1 c1.3,1.3,2.7,2.7,4,3.9l1.6-1.5c-1.3-1.3-2.7-2.7-4-4C4,2.4,3.9,2.3,3.8,2.2c0.2,0,0.3,0,0.4,0c1,0,2.1,0,3.1,0V0 C5,0,2.6,0,0.3,0C0.2,0,0.1,0,0,0C0,0.5,0.1,0.9,0.1,1.3"/> <path id="Fill-10" class="st0" d="M20.7,0.1c-1.9,0-4,0-6,0v2.1c1,0,1.9,0,2.9,0c0.2,0,0.4,0,0.6,0C18,2.4,18,2.5,17.9,2.6 c-1.3,1.3-2.7,2.6-3.9,3.9L15.5,8c1.3-1.3,2.7-2.6,4-4c0.1-0.1,0.2-0.1,0.3-0.2c0,0.2,0,0.3,0,0.4c0,1,0,2,0,3.1H22 c0-2.3,0-4.7,0.1-6.9c0-0.1,0-0.2,0-0.3C21.5,0.1,21.1,0.1,20.7,0.1"/> </g> </g> </g> </g> </g> </g> </g> </svg> </div> </div> </a> </div> </div> <div class="media-desc"> <div class="gallery-count"> <p> FIGURE: <span class="current-img"> 1 </span> / <span class="img-total-count"> 99</span></p> </div> <div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> CD45 Antibody (12-0451-82) in Flow </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> C57BL/6 mouse bone marrow cells were stained with TER-119 Monoclonal Antibody, FITC (Product # 11-5921-82) and 0.015 µg of Rat IgG2b kappa Isotype Control, PE (Product # 12-4031-83) (left) or 0.015 µg of CD45 Monoclonal Antibody, PE (right). Total viable cells were used for analysis. </span> <span class="verification-info hide" ng-if="$ctrl.hasVerificationMethod"> <a rel="nofollow" ng-href="{{$ctrl.currentElement.advancedVerification.uri}}" >{{ $ctrl.currentElement.advancedVerification.fullName }} validation info.</a> </span> <a href="#" class="images-view-more-text hide" ng-if="$ctrl.showViewMore" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)"> View more </a> </div> </div> <div class="img-desc-footer"> <div class="benchsci-pubmed-footer"> <div ng-cloak ng-if="$ctrl.currentElement.benchsci || $ctrl.sourceType === '3'" class="images-benchsci-footer"> <div class="images-benchsci-link" tabindex="0"> <span>Published figure supplied by</span> <span class="icon-benchsci-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 89.75 23.21"><defs><style>.cls-1{fill:#222222;}</style></defs><title>benchsci-logo</title><g id="logo-blue-copy-3"><g id="logo-blue-copy-2"><path id="path14" class="cls-1" d="M34.54,11.49a2.45,2.45,0,0,0,1.59-2.34c0-1.69-1.21-2.94-3.32-2.94H28.88v10.9h4.21a3.06,3.06,0,0,0,3.37-3A2.57,2.57,0,0,0,34.54,11.49ZM31,8h1.49c1,0,1.57.53,1.57,1.36a1.36,1.36,0,0,1-1.55,1.37H31Zm1.72,7.35H31V12.47h1.75a1.42,1.42,0,0,1,1.62,1.46C34.34,14.79,33.72,15.34,32.69,15.34Z"/><path id="path16" class="cls-1" d="M41.34,9.32a3.8,3.8,0,0,0-3.72,4,3.83,3.83,0,0,0,3.91,4.05A3.39,3.39,0,0,0,45,15l-1.71-.51a1.67,1.67,0,0,1-1.72,1.15,1.85,1.85,0,0,1-1.91-1.73H45s0-.34,0-.63C45.09,10.81,43.69,9.32,41.34,9.32Zm-1.66,3.15A1.63,1.63,0,0,1,41.37,11a1.52,1.52,0,0,1,1.69,1.49Z"/><path id="path18" class="cls-1" d="M50.58,9.35a2.48,2.48,0,0,0-2.18,1.14v-1h-2v7.57h2.05V12.75a1.42,1.42,0,0,1,1.41-1.57,1.34,1.34,0,0,1,1.4,1.52v4.42h2V12.35C53.32,10.68,52.46,9.35,50.58,9.35Z"/><path id="path20" class="cls-1" d="M58.2,15.47a1.94,1.94,0,0,1-1.94-2.14,1.92,1.92,0,0,1,1.91-2.12,1.64,1.64,0,0,1,1.67,1.27l1.83-.61a3.45,3.45,0,0,0-3.55-2.55,3.83,3.83,0,0,0-2.82,1.16,3.88,3.88,0,0,0-1.1,2.85,3.9,3.9,0,0,0,4,4,3.5,3.5,0,0,0,3.53-2.55l-1.8-.6A1.72,1.72,0,0,1,58.2,15.47Z"/><path id="path22" class="cls-1" d="M67,9.35a2.72,2.72,0,0,0-2.07.83V6h-2V17.12h2V12.67a1.43,1.43,0,0,1,1.42-1.48,1.34,1.34,0,0,1,1.4,1.53v4.41h2V12.35A2.67,2.67,0,0,0,67,9.35Z"/><path id="path24" class="cls-1" d="M75.82,11.05l-1.63-.35a1.58,1.58,0,0,1-1.4-1.59A1.93,1.93,0,0,1,74.9,7.3a2.21,2.21,0,0,1,2.3,1.86l1.36-.48a3.73,3.73,0,0,0-7.29.54,3,3,0,0,0,2.67,3l1.55.33c1.09.24,1.63.91,1.63,1.7,0,.95-.74,1.74-2.25,1.74a2.51,2.51,0,0,1-1.79-.63,2.45,2.45,0,0,1-.82-1.71l-1.45.46a3.79,3.79,0,0,0,4.08,3.24c2.32,0,3.76-1.52,3.76-3.22C78.65,12.59,77.63,11.45,75.82,11.05Z"/><path id="path26" class="cls-1" d="M83.25,16A2.33,2.33,0,0,1,81,13.41a2.31,2.31,0,0,1,2.24-2.59,1.93,1.93,0,0,1,2,1.57l1.31-.55a3.22,3.22,0,0,0-3.29-2.35,3.7,3.7,0,0,0-3.72,3.92,3.75,3.75,0,0,0,3.74,3.94A3.41,3.41,0,0,0,86.59,15l-1.28-.55A2,2,0,0,1,83.25,16Z"/><path id="path28" class="cls-1" d="M88.69,5.89a1,1,0,1,0,.75.29A1,1,0,0,0,88.69,5.89Z"/><polygon id="rect30" class="cls-1" points="87.99 9.72 89.42 9.72 89.42 17.11 87.99 17.11 87.99 9.72"/><path id="path32" class="cls-1" d="M14.58,8.87A4.1,4.1,0,0,0,15.8,6H14.31a2.62,2.62,0,0,1-.76,1.87L11.66,9.7l-2-2A2.61,2.61,0,0,1,9,6H7.53A4.09,4.09,0,0,0,8.74,8.87l1.87,1.87L8.74,12.61a4.08,4.08,0,0,0-1.21,2.92v2.29H9.18V16.73h1.66v1.09h1.64V16.73h1.65v1.09H15.8V15.53a4.11,4.11,0,0,0-1.21-2.92l-1.38-1.36-1,1.05,1.37,1.36a2.63,2.63,0,0,1,.77,1.58H9a2.68,2.68,0,0,1,.76-1.58Z"/><path id="path34" class="cls-1" d="M11.61,23.21a11.61,11.61,0,1,1,11.6-11.6A11.6,11.6,0,0,1,11.61,23.21Zm0-21.89A10.29,10.29,0,1,0,21.9,11.61,10.28,10.28,0,0,0,11.61,1.32Z"/></g></g></svg> </span> <span id="bechsci-tooltip-{{$ctrl.productId}}" class="bechsci-tooltip-icon" data-toggle="tooltip" ng-click="$ctrl.showBechSciTooltip()" close-tooltip="$ctrl.closeBechSciTooltip()" data-html="true" title="Clicking this link will redirect you to the <a href='https://www.benchsci.com/' target='_blank'> BenchSci</a> website that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented."> <?xml version="1.0" encoding="utf-8"?>  <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 16 16" style="enable-background:new 0 0 16 16;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;} </style> <g id="Log-In-_x2F_-Out-States"> <g id="_x31_200-00-AB-PDP-Logged-Out-Card" transform="translate(-953.000000, -1013.000000)"> <g id="icons_x2F_16_x2F_info_x2F_bold" transform="translate(952.000000, 1012.000000)"> <path id="Shape" class="st0" d="M9,4c2.8,0,5,2.2,5,5s-2.2,5-5,5s-5-2.2-5-5S6.2,4,9,4 M9,2C5.1,2,2,5.1,2,9s3.1,7,7,7s7-3.1,7-7 c0-1.9-0.7-3.6-2.1-4.9S10.9,2,9,2z M8,8.5v4.4h2V8.5H8z M8,5.2v2h2v-2H8z"/> </g> </g> </g> </svg> </span> </div> </div> <div ng-cloak ng-if="$ctrl.currentElement.benchSciPubmedId && $ctrl.currentElement.benchSciPubmedId != '0'" class="pubmed-link"> <span ng-class="$ctrl.getSeperatorClass()">PMID: <a target="_blank" href="http://pubmed.ncbi.nlm.nih.gov/pubmed/{{ $ctrl.currentElement.benchSciPubmedId }}">{{$ctrl.currentElement.benchSciPubmedId}}</a> </span> </div> </div> <div class="btn-view-product" ng-cloak ng-show="false"> <a role="button" class="btn img-view-product"> View Product </a> </div> </div> </div> <div ng-show="$ctrl.isVideo" class="video-desc hide"> <h2 class="product-name" ng-bind="$ctrl.videoTitle"></h2> <p>{{$ctrl.videoDesc}}</p> <p>{{$ctrl.videoLongDesc}}</p> </div> </div> </div> <div class="nav-arrow" ng-if="!$ctrl.isMobileSmallTabletScreen()" onclick="window.THERMO_FISHER.inp.onClickOfRightArrow(event, this)"> <div tabindex="0" class="gallery-right-arrows icon-gallery-arrow-right"> </div> </div> </div> <image-gallery-key-nav pdp-gallery="true"></image-gallery-key-nav> <div class="film-strip"> <div id="custom-scrollbar" class="set-of-images"> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="710847" data-index="0"> <img src="https://www.thermofisher.com/antibody/images/150/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1018375" data-index="1"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24425_ijms-23-08238-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1111341" data-index="2"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1139189" data-index="3"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020387" data-index="4"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24743_fphar-13-1095757-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020330" data-index="5"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24778_jci-132-160097-g179.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020368" data-index="6"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g201.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020349" data-index="7"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24779_jciinsight-7-159875-g200.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020254" data-index="8"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1131754" data-index="9"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="952742" data-index="10"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_20586_jciinsight-7-154824-g203.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020311" data-index="11"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_21405_jci-132-157338-g101.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="952697" data-index="12"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020292" data-index="13"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_24777_ppat.1010342.g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="1020273" data-index="14"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19229_LSA-2021-01315_FigS1.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933482" data-index="15"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933459" data-index="16"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933461" data-index="17"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19102_elife-73215-fig3.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933439" data-index="18"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15194_fimmu-12-763067-g001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933412" data-index="19"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933420" data-index="20"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15193_gr4.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933394" data-index="21"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933356" data-index="22"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g006.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932265" data-index="23"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932246" data-index="24"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933375" data-index="25"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g007.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932284" data-index="26"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933337" data-index="27"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15181_ACEL-20-e13412-g004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932303" data-index="28"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933317" data-index="29"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15180_elife-66063-fig1.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933299" data-index="30"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933280" data-index="31"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933242" data-index="32"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932340" data-index="33"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933204" data-index="34"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933223" data-index="35"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933185" data-index="36"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15187_fcell-09-672032-g005.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933166" data-index="37"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15175_JEV2-10-e12109-g003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933147" data-index="38"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15175_JEV2-10-e12109-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933261" data-index="39"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15189_gr2.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843479" data-index="40"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12875_gr3.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933128" data-index="41"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15174_gr1.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933108" data-index="42"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15173_395_2021_869_Fig4_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933089" data-index="43"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15185_cells-10-00940-g004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932835" data-index="44"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932854" data-index="45"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933051" data-index="46"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933049" data-index="47"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15061_mmcfigs2.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932131" data-index="48"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843448" data-index="49"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12873_SN-ENUJ210063F005.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="854836" data-index="50"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9883_ijms-22-01546-g001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933013" data-index="51"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15171_EMBJ-40-e105123-g017.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932994" data-index="52"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15171_EMBJ-40-e105123-g009.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932322" data-index="53"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932778" data-index="54"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855317" data-index="55"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9905_fimmu-11-607564-g010.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855339" data-index="56"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853691" data-index="57"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9861_gr4_lrg.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853639" data-index="58"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9861_gr3_lrg.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933069" data-index="59"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15184_MUS-63-600-g005.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932721" data-index="60"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15182_fnut-07-583186-g0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932740" data-index="61"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932759" data-index="62"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932113" data-index="63"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853444" data-index="64"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig2.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853526" data-index="65"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig6.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853484" data-index="66"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9859_elife-60223-fig3.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932702" data-index="67"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932683" data-index="68"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855279" data-index="69"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9904_fnmol-13-00149-g0002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855298" data-index="70"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9904_Image_3.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932975" data-index="71"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932956" data-index="72"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932937" data-index="73"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932918" data-index="74"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932899" data-index="75"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932880" data-index="76"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="839066" data-index="77"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12428_fcimb-10-557610-g0003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="850844" data-index="78"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_8375_thnov10p11376g001.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932664" data-index="79"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932645" data-index="80"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932626" data-index="81"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="851620" data-index="82"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9817_jciinsight-5-136773-g165.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855260" data-index="83"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9903_jciinsight-5-137713-g026.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853220" data-index="84"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9852_cancers-12-02083-g004.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="853181" data-index="85"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9852_cancers-12-02083-g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855238" data-index="86"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932797" data-index="87"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932607" data-index="88"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15169_gr4_lrg.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932588" data-index="89"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843401" data-index="90"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="841382" data-index="91"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="841325" data-index="92"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932550" data-index="93"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843381" data-index="94"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="735679" data-index="95"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_7910_ijbsv16p1526g002.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="850146" data-index="96"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_7910_ijbsv16p1526g003.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="932531" data-index="97"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19108_MMR-21-05-2085-g00.jpg?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="863160" data-index="98"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time=20240507" alt="CD45 Antibody"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">C57BL/6 mouse bone marrow cells were stained with TER-119 Monoclonal Antibody, FITC (Product # 11-5921-82) and 0.015 µg of Rat IgG2b kappa Isotype Control, PE (Product # 12-4031-83) (left) or 0.015 µg of CD45 Monoclonal Antibody, PE (right). Total viable cells were used for analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24425_ijms-23-08238-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Clonal assay of MSCs after co-culture with HSCs. ( A ) Representative flow cytometric profiles of MSCs (upper, CD31 - , CD45 - , Ter119 - , Sca-1 + , and PDGFR-alpha + cells) and HSCs (bottom, c-Kit + , Lin - , and Sca-1 + cells). Microscopic views of MSCs (upper) and HSCs (bottom). ( B , C ) Cell proliferation of MSCs ( B ) and HSCs ( C ) 2, 4, 6, and 8 days after co-culture ( n = 6). * p < 0.05 and ** p < 0.01 between direct and indirect co-culture. ( D ) MSC and HSC population in whole mesenchymal and hematopoietic cells. MSCs were sorted on day -1, and we waited until they attached to the bottom of the dish on day 0. After co-culture of MSCs and HSCs for 3, 5, and 7 days, cells were collected, sorted based on EGFP expression, and both cell types were detected using stem cell markers by flow cytometry. ( E ) Real-time PCR analysis of mesenchymal lineage marker expression in MSCs following a 3-week treatment with mesenchymal differentiation media after co-culture with HSCs ( n = 5). * p < 0.05 vs. MSCs (-HSCs).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29165_12951_2023_2145_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Morphology and characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) and hUCMSC exosomes. a Appearance of MSC fibroblast sample, as shown based on an optical microscope image (x40). b The surface markers of hUCMSCs were analyzed via flow cytometry. hUCMSCs tested positive for CD73, CD105, and CD90, but were negative for CD34, CD14, CD19, CD45, and HLA-DR. c MSCs had the ability to differentiate into adipocytes (x40). d MSCs also had the ability to differentiate into chondrocytes (x40). e MSCs had the ability to differentiate into osteoblasts (x40). f Exosome morphology observed via transmission electron microscopy. g The particle size distribution of exosomes measured using NANOSIGHT software. h Western blot analyses of the exosome surface markers (CD9, CD81, and CD63)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29061_urn-x-wiley-17574676-media-emmm202216836-emmm202216836-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">3 Figure RBC-hitchhiking improves neoantigen-specific T-cell response of DNA nanovaccines A Scheme of the immunization procedure of RBC-Nanovaccines. B, C The expression of MHC I in CD11c + DCs and the percentage of CD45 + CD3 + , CD3 + CD4 + , and CD3 + CD8 + T cells in the spleen were analyzed by flow cytometry at the 11 th day after treatment with PBS, Nanovaccines, and RBC-Nanovaccines once or twice. n = 5 animals per group in (C); data were pooled from two independent experiments. D ELISA analysis of the concentration of TNF-alpha, IFN-gamma, and CRP in the peripheral blood of mice after different treatments ( n = 3-5 animals per group). E ELISPOT analysis of IFN-gamma spot-forming. F The corresponding quantification numbers of spots in (E). n = 5 animals per group; data were pooled from two independent experiments. Data information: Data in (C), (D), and (F) are presented as mean +- SD. Statistical significance was calculated by one-way ANOVA with Tukey's multiple comparison test in (C, D) and two-tailed Student's t -test in (F). * P < 0.05, ** P < 0.01 and *** P < 0.001. ns means no significant difference. Source data are available online for this figure.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24743_fphar-13-1095757-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 2 Alteration of cellular composition in the diseased status of mice and humans. (A,B) Fractions of major cells types in aneurysmal aorta vs. the corresponding normal aorta of humans (A) and mice (B) . (C) Immunofluorescence analysis for SMMHC (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the human vascular media (scale bars: 100 mum). Lu means the lumen side of the vascular wall, and A means the adventitia side of the vascular wall. (D,E) Immunofluorescence analysis for vimentin (white) (D) and CD45 (purple) (E) and overlays with DAPI-labeled nuclei (blue) showing fibroblasts and immune cells in the human aorta (scale bars: 100 mum). (F) Immunostaining for calponin (red), alphaSMA (green), and overlays with DAPI-labeled nuclei (blue) showing smooth muscle cells in the mouse aortic media (scale bars: 100 mum). (G) Immunostaining for vimentin (white) and DAPI overlay in the thoracic and abdominal aorta form mice subjected to 4 weeks of Ang II induction (scale bars: 500 mum). (H) Immunostaining for CD45 (red), CD68 (green), and overlays with DAPI-labeled nuclei (blue) showing macrophages in the mouse aorta (scale bars: 100 mum). (I) Flow cytometry of the proportion of macrophages (F4/80 + CD11B + ), monocytes (LY6C + CD11B + ), and T cells (CD3 + ) in CD45 + immune cells among three groups (n = 3-4, per group).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24778_jci-132-160097-g179.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 GPR92 deficiency triggers proinflammatory responses and increases the expansion of M1-like IMs. ( A ) Flow cytometry analysis of CD45 + cells in the islets from WT or KO mice on a HFD, n = 6-4/group. ( B ) CD45 and CD11b double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n = 3-4/group. ( C ) F4/80 and CD11c double-positive cells (Q4) in the islets from WT and KO mice on a NCD or a HFD, n = 3-5/group. ( D ) Immunofluorescence of the pancreas. Scale bars: 20 mum. ( A - D ) Data and images are representative of at least 3 independent experiments. All data are expressed as mean +- SEM. *** P < 0.001, ** P < 0.01, * P < 0.05 by 2-way ANOVA with Bonferroni's post hoc. ( E ) Top 15 most-relevant, upregulated (red) and downregulated (blue) genes in the islet from WT versus KO mice on a HFD. Mean values from n = 4-5/group. ( F ) Volcano plot of the fold change ( x axis) versus adjusted (adj.) P value ( y axis) of the transcriptomes between the islets from WT and KO mice on a HFD. Genes highlighted in red or blue are based on the thresholds of log 2 fold change > 1 and adj. P < 0.05. ( G ) Pathways of the islets from WT versus KO mice on a HFD that were either activated (red) or repressed (blue) by lack of GPR92. Normalized enrichment score (NES) is represented in log 10 ( P ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g201.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx diaphragms. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) and prednisolone-treated (PRD-treated) 4.5-week-old mdx diaphragms compared with vehicle (VEH) controls. n = 6 replicates per group pooled from 2 mice each were used. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ), or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P <= 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24779_jciinsight-7-159875-g200.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Muscle leukocyte analysis in spironolactone- and prednisolone-treated mdx quadriceps. ( A - F ) Representative flow cytometry gating dot plots displaying CD45 + CD11b + myeloid cells ( A ), CD45 + CD11b + LY6G + neutrophils ( B ), CD45 + CD11b + LY6G - CD64 - LY6C hi infiltrating monocytes ( C ), CD45 + CD11b + LY6G - CD64 + macrophages ( D ), CD45 + CD11b + LY6G - CD64 + CD206 + macrophages ( E ), and CD45 + CD11b + LY6G - CD64 + F4/80 hi macrophages ( F ) from spironolactone-treated (SPR-treated) ( n = 13) and prednisolone-treated (PRD-treated) ( n = 13) 4.5-week-old mdx quadriceps compared with vehicle (VEH) ( n = 12) controls. ( G ) Quantification of myeloid cells, neutrophils (Nphi), infiltrating monocytes (Inf. MO), macrophages (MPhi), CD206 + macrophages (CD206 + ), and F4/80 hi macrophages represented as dot plots for cells per milligram of muscle (Cells/mg). ( H ) Bar graphs with individual data points as percentages of total CD45 + leukocytes (%CD45 + ), CD45 + CD11b + myeloid cells (%CD45 + CD11b + ) or macrophages (%CD45 + CD11b + LY6G - CD64 + ) comparing SPR- and PRD-treated mice with VEH controls. Experimental replicates are denoted by black and gray dots within the graphs. Statistics used were ANOVA with the BKY test * P <= 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24737_urn-x-wiley-08941491-media-glia24255-glia24255-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">1 FIGURE Flow cytometry analysis of the CD11b+ cells. Cells isolated from non-perfused [(a)-(e)] and perfused [(f)-(j)] brains did not show significant differences. [(a), (f)] Histograms showing two CD45-expressing cell populations: CD45 low (microglia) and CD 45 high (possible macrophages). [(b), (g)] Microglia, identified as CD11b+ and CD45 low (Q3), comprised the highest proportion of cells (91.7%-94.5%), whereas a low percentage of potential macrophages (CD11b+/CD45 high, Q2) were observed. [(c), (h)] Forward scatter (FSC) analysis showing a slight smaller size of the CD45 low cells (red) respect to CD45 high (blue) cells. [(d), (i)] CD11b analysis showed a slight lower expression within CD45 low cells (red) respect to CD45 high (blue) cells. [(e), (j)] Forward scatter (FSC) and side scatter (SSC) characteristics of CD11b+/CD45 low (red) and CD11b+/CD45 high (blue) are shown</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_21207_41586_2022_4895_Fig7_ESM.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 3 Gating strategies for cell sorting. Panels a-d, e-h, i-l and m-p represents gating strategies for Fig. 3a, b, h and k . Briefly, a panel represents the gating for cells, eliminating the cell debris followed by single cell selection in b , eliminating doublets. Panel c represents gating strategy for live/dead cells. Live cells selected from c , was subjected to cell sorting based on EpCam and CD45 cells in d . Sorted cells obtained from d was analyzed in Fig. 3a . The same chronology is maintained for panels: e-h, i-l and m-p .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20586_jciinsight-7-154824-g203.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Therapeutic potential of i.n. afatinib and pemigatinib application in acute EAE. ( A and B ) Clinical course (left) and linear regression analysis (right) of EAE in mice after daily i.n. treatment with vehicle, afatinib ( A ), or pemigatinib ( B ) starting from symptom onset. The experiment was repeated twice. Vehicle (PBS), n = 10; afatinib, n = 10; pemigatinib, n = 10. Data are reported as mean +- SEM. ( C ) Unsupervised clustering t-distributed stochastic neighbor embedding (t-SNE) plot overlaid with cluster and their abundance ( D ) identified by unsupervised PhenoGraph clustering of high-dimensional flow cytometry data obtained from CNS (brain and spinal cord) tissue at peak of disease from mice treated with afatinib ( n = 5) or vehicle ( n = 5). ( E and F ) Quantification ( E ) and scatter plots ( F ) of CD45 - CD11b - , CD45 int CD11b + , CD45 hi CD11b + , and CD45 + CD11b - cell populations in the CNS of mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease. Two-way ANOVA with Sidak's multiple comparisons test. ( G ) Significant differences in CNS-resident and -infiltrating cell populations in mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease, identified by SAM analysis () (FDR cutoff, 0.1). ( H and I ) Intracellular flow cytometry quantification of iNOS, TNF-alpha, and GM-CSF in astrocytes ( H ) and microglia ( I ) in mice treated with afatinib ( n = 5) or vehicle ( n = 5) at peak of disease. ( J ) Relative expression of</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_21405_jci-132-157338-g101.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Downregulated ZIP8/SIRT1 signaling and decreased renewal capacity of AEC2s from old mouse lungs. ( A ) Flow cytometry analysis to gate out total AEC2s (R2), and ZIP8 expression AEC2s (R3) from lung homologies of young and old mice. ( B ) Percentage of ZIP8 + cells (R3) within total AEC2s ( n = 5-6, ** P < 0.01). ( C ) Number of ZIP8 + cells recovered from young and old mouse lung ( n = 5-6, ** P < 0.01). ( D ) CFE of mouse AEC2s isolated from young and old mouse lungs ( n = 6-7, ** P < 0.01). ( E and F ) Flow cytometry analysis of ZIP8 expression in gated AEC2s cultured with medium only or medium containing 100 muM ZnSO 4 ( n = 6, *** P < 0.001). ( G - J ) 3D organoid culture of AEC2s isolated from lungs of 2.5-, 12-, 14-, and 18-month-old mice with and without 100 muM ZnSO 4 treatment. ( G ) CFE ( n = 3-4, * P < 0.05, *** P < 0.001, **** P < 0.0001 by ANOVA). ( H - J ) Expression of Slc39a8 ( H ), Sftpc ( I ), and Pdpn ( J ) in AEC2s derived from 3D-cultured organoids with and without ZnSO 4 treatment by qPCR ( n = 3-4, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 by ANOVA). ( K ) Violin plots of gene expression in AEC2s from lungs of bleomycin-treated young and old mice. ( L ) IPA pathway analysis of AEC2s from young and old mice on day 4 after bleomycin injury. ( M and N ) CFE of AEC2s from uninjured 10- to 12-week-old young mice treated with SRT1720 ( n = 3-6, ** P < 0.01, **** P < 0.0001 by ANOVA) ( M ) and splitomicin ( n = 5-6, **** P < 0.0001 by ANOVA) ( N</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20584_11658_2022_325_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Systematic quality evaluation of clinical-grade IL10-MSCs. A The IL10 protein level in the supernatant of different IL10-MSCs clones (P5-6). MSCs with blank vector transfection were the control. B With the increase in the number of passages, the IL10 secretion gradually decreased in IL10-MSCs, but still sustained a high level. C Morphological characterization of IL10-MSCs (P6) compared with naive MSCs (P6) under light microscopy. D Representative karyotype analysis. Control MSCs (left, P6) and IL10-MSCs (right, P6) both had normal karyotypes. E Flow cytometric analysis showed IL10-MSCs were positive (> 95%) for mesenchymal lineage markers (CD73, CD90, and CD105) and negative (< 2%) for hematopoietic and endothelial markers (CD14, CD19, CD34, CD45, and CD3) as well as for HLA-DR, in accordance with the criteria of clinical-grade MSCs. F1-2 Tumorigenesis analysis showed that there was no tumor formation observed in any SCID mice injected with IL10-MSCs, but tumor was formed in positive control SCID mice with HESCs transplantation. Further H&E staining showed no infiltration of tumor cells at the cell injection site and main organs after IL10-MSC injection. G - I Differentiation potential of IL10-MSCs in adipocytes, osteocytes, and chondrocytes stained with Oil red O, Alizarin Red, and Alcian Blue, respectively. IL10-MSCs maintained multiple lineage potential, but with downregulated adipogenic differentiation capability</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24777_ppat.1010342.g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.ppat.1010342.g002 Fig 2 Immune cell infiltration is impaired in BEX1 KO hearts during CVB3 infection. A) Hematoxylin and Eosin staining was conducted in WT and BEX1 KO mice following the indicated treatments. Scale bar = 125mum. B) The gating of CD45+ cells in representative WT and BEX1 KO 7 days post-infection hearts is shown for total leukocyte abundance using flow cytometry. D-K) Total Leukocytes (C), T lymphocytes (D), total monocytes (E), natural killers (F), B lymphocytes (G), myeloid-derived cells (H), neutrophils (I), infiltrating monocytes (J), and macrophages (K) were evaluated in WT and BEX1 KO hearts at the indicated post-infection time points using flow cytometry. d = days. Statistical analyses by 2-way ANOVA. (* p<0.05 CVB3-treated WT vs. uninfected WT; & p<0.05 CVB3-treated BEX1 KO vs. uninfected BEX1 KO; # p<0.05 BEX1 KO vs. WT same treatment).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19229_LSA-2021-01315_FigS1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure S1. TNF inhibits M2 gene expression (related to Fig 1 ). (A) Gating strategy of wild-type BMDMs stained for Arg1, RELMalpha, and CD301. (B) Representative blots of wild-type BMDMs stimulated with IL4/IL13 or IL4/IL13 + TNF and percentages of RELMalpha + and CD301 + macrophages were determined by flow cytometry analysis. (C) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, or left untreated and percentages of CD301 + of F4/80 + macrophages were determined by flow cytometry analysis. (D) Representative blots for Fig 1D . (E) Wild-type BMDMs were stimulated with IL4/IL13, IL4/IL13 + TNF, and/or Etanercept and percentages of Arg1 + of F4/80 + macrophages were determined by flow cytometry analysis. Data represent three independent experiments. (F) Gating strategy for the sorting of wound macrophages. Representative flow cytometry analysis of single cell suspensions isolated from Balb/c wild-type wound tissue at 14 dpi. 7-AAD - single cells were gated and analyzed for expression of CD45 and CD11b. 7-AAD - CD45 + CD11b + cells were gated and analyzed for expression of CD11b and F4/80. 7-AAD - CD45 + CD11b + F4/80 + cells were sorted by flow cytometry. (G) Gating strategy of small peritoneal macrophages from solvent or Etanercept-treated mice stained for Arg1 and RELMalpha. All values are means +- SEM; * P < 0.05; **** P < 0.0001. Statistically significant differences were determined by one-way ANOVA with Tukey correction. If not indicated otherwise superscripts</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19144_12951_2021_1162_Fig11_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 11 The mechanism of distant antitumor effect analysis. The flow cytometry images of DCs (CD80 + CD86 + ) mature ( A ) and quantitative analysis ( B ); flow cytometry ( C ) and quantitative analysis ( D , E ) of activated CD3 + CD4 + CD8 + T cells after each treatment; the population of CD4 + Foxp3 + Tregs in the spleen according to flow cytometry ( F ) and the ratio of CD3 + CD8 + cytotoxic T cells versus CD3 + CD4 + Foxp3 + Tregs ( G ); flow cytometry analysis of CD45 + , F4/80 + ( H ) and quantitative analysis ( I , J ) in the distant tumor</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19142_41467_2021_26882_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Reduced neuroinflammation in CD4-P2Y10-KOs. a Neurological score ( n = 8; * p = 0.037 (d24), 0.0189 (d25)). b Quantification of demyelination by luxol fast blue (LFB) staining on day 28 after induction of EAE: Exemplary photomicrographs (left) and statistical evaluation (right) ( n = 8; * p = 0.039). Repetition of EAE in an independent cohort ( n = 8-9): Neurological score ( c ; * p = 0.019 (d20), 0.033 (d21)) and flow cytometric analysis of spinal cord-infiltrating leukocytes on day 20 ( d - g ): Absolute numbers of CNS-infiltrating T cells ( d ; ** p = 0.001), proportion of FoxP3, IFNgamma-, IL-17A- ( e ; ** p = 0.008) or GMCSF- ( f ; ** p = 0.003) expressing cells among infiltrating CD4 cells, absolute numbers of CD11b + ,CD45 hi macrophages ( g ; *** p < 0.001). h Quantification of Mac3-positive cells in lumbar CNS: Exemplary photomicrographs (left) and statistical evaluation (right) ( n = 8; ** p = 0.009) (same mice as in a , b ). Data are means +- SEM; comparisons between genotypes were performed using two-tailed unpaired Student's t- test ( b , d - h ) or two-way ANOVA with Tukey's multiple comparisons test ( a , c ). n , number of mice per group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19102_elife-73215-fig3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3. Myofiber-specific ablation of IRE1alpha reduces abundance of satellite cells in injured muscle. ( A ) Representative photomicrographs of uninjured and 5d-injured TA muscle sections of Ern1 fl/fl and Ern1 cKO mice after immunostaining for Pax7 (red) and laminin (green) protein. Nuclei were identified by staining with DAPI. Scale bar: 50 um. White arrows point to Pax7 + satellite cells. ( B ) Average number of Pax7 + cells per field (~0.15 mm 2 ) in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. n = 6 mice per group. ( C ) Relative mRNA levels of Pax7 in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by performing qPCR (n = 3-5 mice in each group). ( D ) Representative immunoblots showing levels of Pax7 and unrelated protein GAPDH in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( E ) Primary mononuclear cells were isolated from TA muscle of Ern1 fl/fl and Ern1 cKO mice and subjected to FACS analysis for satellite cells. Representative FACS dot plots demonstrating the percentage of alpha7-integrin + cells in 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice. ( F ) Quantification of alpha7-integrin + satellite cells in uninjured and 5d-injured TA muscle of Ern1 fl/fl and Ern1 cKO mice assayed by FACS (n = 4 or 5 mice in each group). Data are expressed as mean +- SEM and analyzed by one-way analysis of variance (ANOVA) followed by Tukey's multiple comparison test. * p <= 0.05, values significantly</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15194_fimmu-12-763067-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 FCM analysis of dynamic changes of M1-like and M2-like uterine macrophages during the peri-implantation period in mice. (A) Gating strategy used to identify uterine M1-like macrophages (CD45 + F4/80 + CD206 - ) and M2-like macrophages (CD45 + F4/80 + CD206 + ) in pregnant mice. FSC vs SSC gating was used to clean up the debris and dead cells. CD45 + represents leukocyte; F4/80 + represents macrophages; CD206 - and CD206 + represent M1-like and M2-like uterine macrophages, respectively. (B) Dynamic changes of M1-like macrophages, M2-like macrophages and Mphi during peri-implantation period in mice (n>=3). Error bars represent means +- SEM; two-tailed unpaired t-test, ns, not significant, *P < 0.05 or ***P < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15066_41536_2021_180_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Isolation and characterization of mesenchymal stem cells. a Schematic showing isolation of mouse bone marrow cells (BMCs) and its properties of self-renewal and differentiation of MSCs. b Representative microscopic images displaying isolated bone marrow cells that show circular and round-shaped morphology of BMCs; whereas, adhered MSCs show fibroblast or eye-shaped morphology. c Immunofluorescence images of MSCs showing the expression of MSC-positive markers (CD29, CD44, and SCA1). d Immunophenotypic characterization of MSCs using flow cytometer showing the absolute counts of MSC positive markers such as CD29, CD44, and SCA1, as well as expression of MSC-negative (CD34, CD45, and CD11b). Isotype controls for each antibody were used as controls and FITC/rhodamine-conjugated secondary antibodies were used for their detection. e Bar graph (quantification from four independent experiments (expressed as mean +- standard error)) showing the percentage of cells expressing the MSC-positive and negative markers respectively. f , g Immunophenotypic characterization of BMCs using flow cytometer showing expression various markers (CD29, CD44, CD45, and CD11b). Bar graph expressed as mean +- standard error shows quantification of respective markers from three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15193_gr4.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Cardiac-derived TGF-beta1 alters gene expression programs and inflammation in white adipose tissue. ( A ) Heat map generated using differentially expressed genes from RNA sequencing of perigonadal white adipose tissue (pgWAT) from WT and TGF mice under control and high-fat diet. ( B ) Gene ontology analysis comparing RNA sequencing of TGF and WT pgWAT under control and high-fat diet. ( C ) Body mass of WT and TGF mice following 2 weeks of control or high-fat diet. ( D ) Flow cytometry for CD45-positive cells (CD45+) in pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. ( E ) qPCR for CD74 normalized to Ppia housekeeping gene from pgWAT from the indicated genotypes following 2 weeks of control or high-fat diet. Statistics were calculated using a two-way ANOVA, where * indicates p < 0.05. Data are presented as the mean +- SEM. Group sizes are listed in the order of CD WT, CD TGF, HFD WT, and HFD TGF: (A, B) n = 3, 3; (C) n = 11, 13, 20, 15; (D) n = 4, 4, 4, 4; and (E) n = 12, 10, 11, 10. Figure 4</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15190_41467_2021_25417_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 PTENalpha promotes tumor immune escape. a - g Cancer vaccination model of Mock or PTENalpha transfected Pten -/- B16 cells. a Schematic diagram of the cancer vaccine model. b Tumor volumes of C57BL/6 mice subjected to the cancer vaccination model were monitored overtime. The unimmunized group refers to mice without irradiated B16 cells immunization. The statistical significances between the immunized groups were indicated (PTENalpha-unimmunized, n = 4 mice; other groups, n = 5 mice, mean +- s.e.m., * P (d16) = 0.0254, * P (d20) = 0.0339, * P (d22) = 0.0487, * P (d24) = 0.0450, ** P = 0.0077). c The tumor-infiltrating lymphocytes (TILs) were isolated when the tumor volumes of the Mock-immunized group reach 200 mm 3 , and the cells were subjected to flow cytometry analysis. The cell counts of CD45 + cells were used for statistical analysis ( n = 4 mice, mean +- SD, ** P = 0.0044). Gating strategies were shown in Supplementary Fig. 3b . d - g TILs were isolated when the tumor volumes of Mock-immunized group reach 200 mm 3 , and CD45 + cells were sorted, using for 10x scRNA-seq with two replicates. 25,098 cells were identified as 12 clusters utilizing graph-based clustering. d Cd8T cells were further analyzed and identified as 4 clusters utilizing graph-based clustering. e Violin plot of differentiated genes in the 4 clusters of Cd8T cells. The color of each violin is the average expression value of a given gene. f and g Umap and proportion of the 4 clusters of Cd8T cells</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g006.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 4 Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">4 FIGURE Surviving aged mice show exhausted T cell phenotype in CNS. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 of 16 week ( left ) and 85 week ( right ) at 30 dpi. (b) Quantification of number of CD11b neg CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b neg -gated cells analyzed by CD8 vs CD45 staining. (d) Quantification of number of CD8 + CD45 + cells in each group. (e) Representative flow cytometry plots of CD8 + -gated cells analyzed by CD8 vs NS4B (WNV-specific tetramer) staining. (f, g) Quantification of (f) number and (g) percent of NS4B + of CD8 + cells in each group. (h) Representative flow cytometry plots of NS4B + -gated cells analyzed by IFNgamma vs NS4B staining. (i, j) Quantification of (i) number and (j) normalized MFI of IFNgamma + of NS4B + CD8 + cells. MFI was normalized within each experiment to the average IFNgamma MFI of NS4B + CD8 + cells isolated from 16 week mice at 30 dpi. Each mouse is represented by a symbol and lines indicate mean +- SD. These data are the representative of three independent experiments with a total of 9-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">3 FIGURE Uninfected aged mice exhibit myeloid cells that lack typical microglial markers. Adult (16 week) and aged (85 week) mice were infected with 100 PFU WNV-NY via footpad inoculation. At 9 dpi, a time point just prior to when mice begin succumbing to viral infection, leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of percent of CD11b + CD45 + cells in 16 week mock, 85 week mock, 16 week infected, and 85 week infected cortex. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression. (d) Quantification of percent CD45 hi , P2RY12 + CD45 lo , and P2RY12 neg CD45 lo cells in each group. (e) Representative flow cytometry plots of P2RY12 + CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of percent MHCII + of P2RY12 + CD45 lo -gated cells in each group. (g) Representative flow cytometry plots of P2RY12 neg CD45 lo -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of percent MHCII + of P2RY12 neg CD45 lo -gated cells in each group. These data are representative of two experiments with 6-10 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. (i) Representative images of 16 week ( top row ) and 85 week ( bottom row ) cortical tissue sections collected fr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g007.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 5 Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">5 FIGURE Surviving aged mice show less microglial activation than young adult mice. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortex and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD45 + -gated cells analyzed by CD11b vs CD45 expression. (b) Quantification of number of CD11b + CD45 + cells in each group. (c) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 + cells. (d) Quantification of number of P2RY12 + CD11b + cells in each group. (e) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs CD68 expression. (f) Quantification of number of CD68 + P2RY12 + cells in each group. (g) Representative flow cytometry plots of P2RY12 + -gated cells analyzed by P2RY12 vs MHCII expression. (h) Quantification of number of MHCII + P2RY12 + cells in each group. These data are the representative of two independent experiments with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15181_ACEL-20-e13412-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 6 Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19136_urn-x-wiley-14749718-media-acel13412-acel13412-fig-0006.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">6 FIGURE Surviving young mice show increased number of CD45 lo P2RY12 neg myeloid cells. 16 week and 85 week mice were infected with 100 PFU WNV-NY via footpad inoculation. At 30 dpi, mice that survived the infection were euthanized, and leukocytes were isolated from the cortices and analyzed by flow cytometry. (a) Representative flow cytometry plots of CD11b + -gated cells analyzed by CD45 vs P2RY12 expression with gating for P2RY12 neg cells. (b) Quantification of number of P2RY12 neg CD11b + cells in each group. (c) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs CD68 expression. (d) Quantification of number of CD68 + P2RY12 neg cells in each group. (e) Representative flow cytometry plots of P2RY12 neg -gated cells analyzed by P2RY12 vs MHCII expression. (f) Quantification of number of MHCII + P2RY12 neg cells in each group. These data are the representative of two experiment with 7-15 mice per group. Statistical significance was calculated using one-way ANOVA with Welch's correction and Dunnett's multiple comparisons test. Exact p values noted; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15180_elife-66063-fig1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1. Two cell populations with skeletal stem cell characteristics in postnatal long bones. ( A ) Diagram showing two previously described skeletal stem cell (SSC) populations and the downstream populations they generate, which were defined by the specific expression patterns of cell surface proteins. Top: SSC lineage tree of the osteochondral SSC (ocSSC) that gives rise to bone, cartilage, and stromal populations. Bottom: the lineage tree of the perivascular SSC (pvSSC) able to give rise to bone, cartilage, adipose tissue, and stromal populations. BCSP: bone cartilage stroma progenitor; CP: cartilage progenitor; APC: adipogenic progenitor cell; Pre-Ad. : pre-adipocyte; OPC: osteochondrogenic progenitor cell. ( B ) Representative flow cytometric gating strategy for the isolation of ocSSCs (top) and pvSSCs (bottom). ( C ) Representative confocal microscopy images of in vivo derived single-color clonal colonies of renal capsule-transplanted purified ocSSCs (left) and pvSSCs (right) derived from Actin-CreERt Rainbow mice. Three independent transplants per cell type under renal capsules were performed. ( D ) Renal capsule transplant-derived ossicles of purified GFP-labeled ocSSCs (top) and pvSSCs (bottom). Images show the photograph of the kidney with transplant (top left) and GFP signal of graft tissue (bottom left) as well as Movat pentachrome cross-section staining (right). ( E ) Quantification of ocSSC (top) and pvSSC (bottom) graft composition. Results of three separate</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15178_11658_2021_273_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Cell characteristics of bone marrow derived macrophages (BMDMs) and mesenchymal stem cells (MSCs). Phase contrast microscopic image of BMDMs 5 days after in vitro culture ( A ). Flow cytometric analysis of BMDMs for F4/80 ( B ). Flow cytometric analysis of MSCs for CD90, CD105, CD34, and CD45 ( C ). CXCL12 gene knockout in MSCs. Transfection of MSCs with a GFP-positive CRISPR/Cas9 plasmid to knock out CXCL12 gene ( D ). Western blotting for knockout efficiency ( E ). beta-actin was used as a control. CXCL12 measurement in the serum-free conditioned media of MSC CXCL12+/+ and MSC CXCL12-/- by ELISA ( F ). Each point indicates an experiment (horizontal lines: mean)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15177_12974_2021_2183_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Flow cytometry analyses of the hypothalamus ( A , B , E ), visceral fat pad ( C , F ), and peritoneal cavity (PEC, D , G ) demonstrated macrophage migration following HFD. E An example of flow cytometry gating, indicating the presence of the CD45 high macrophage population that can be distinguished from the CD45 low microglia specifically in the hypothalami of HFD male mice, but not in female mice. These populations were quantified and presented as the % of all live cells in A (macrophages, CD11b+CD45 high ) and B (microglia, CD11b+Cd45 low ). C Quantification of F4/80+CD11b+ macrophages in the stromal vascular fraction of visceral adipose tissue following Ctr and HFD in males (left) and females (right). F An example of the flow cytometry gating strategy from visceral fat. D , G Peritoneal cavity (PEC) cells were analyzed by flow cytometry (gating example G ) and the percent of F4/80+CD11b+ macrophages of all live cells are presented graphically in D , males on the left and females on the right. n=9-12 total, 3 repeats consisting of 3-4 mice per group. Statistical significance (*) between Ctr (gray bars) and HFD (black bars) were determined by Student's T test followed by Tukey's post hoc test</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15176_41598_2021_91998_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 The resident microglial population increases in proportion and total number in the ipsilateral thalamus at PSD 14. At PSD 14, brains were harvested for cell cytometry. Single cell suspensions were obtained from cortex and thalamus. Cells were stained with CD45 antibody and CD11b antibody to measure the number and percentage of microglia in thalamus . ( A ) Representative cell cytometry plots generated from ipsilateral cortex and thalamus from sham and PSD 14 brains. The percentage of microglia, peripheral myeloid cells (pMyeloids), and lymphocytes is indicated numerically on the plots. ( B ) Illustration showing location of cortex and thalamus harvest sites from brain sections corresponding to + 1 or - 2 mm from bregma. ( C ) Number of CD45 Int /CD11b + cells in cortex and thalamus for sham and PSD 14 brains. * P < 0.05, unpaired t test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15162_urn-x-wiley-1469221X-media-embr202152481-embr202152481-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">1 Figure Adipoq Cre targets BM adipose lineage cells FACS analysis of tdTomato + cells in the bone marrow cells (percentages represent average values). Immunofluorescence staining of aggrecan and DAPI of femur sections from Adipoq Cre ; R26 tdTomato mice. Scale bar = 200/100/50 um in left/ upper right/ bottom right images. CB: cortical bone, TB: trabecular bone. Immunofluorescence staining of RANKL and Hoechst in bone marrow cells from Adipoq Cre ; R26 tdTomato mice. Scale bar = 50 um. qPCR results of Rankl in BMAT and peripheral adipose tissues, including epididymal (eWAT), inguinal (iWAT), and interscapular (iBAT) ( n = 3 independent biological replicates). Data were compared using one-way ANOVA (** indicates P < 0.01), and error bars are standard deviations. Immunofluorescence staining of RANKL during in vitro adipogenesis of BMSCs from Adipoq Cre ; rankl fl/fl mice ( Rankl -/- ) and rankl fl/fl mice ( Rankl +/+ ). Scale bar = 50 mum. Western blotting analyses of RANKL in BMSCs during in vitro BMSCs adipogenesis ( n = 3 independent biological replicates). Data were compared using an unpaired t -test (** indicates P < 0.01), and error bars are standard deviations.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Genetic ablation of IL-6 reverses GBM immunosuppression. GBM was induced by RCAS-mediated genetic engineering in Ntv-a ; Ink4a-Arf -/- ; Pten fl/fl ; LSL-Luc donor mice, followed by orthotopic tumor implantation into Cdh5-Cre ERT2 ; Il6 fl/fl recipient mice that were pretreated with (IL-6-DeltaEC) or without (Control) tamoxifen. Two weeks after tumor implantation, tumors were excised. a Schematic approach. b , c Tumor-derived single-cell suspensions were analyzed by CyTOF. b Representative CyTOF sorting. c Quantitative results (mean +- SEM, n = 4 mice). Statistical analysis by two-tailed Student's t -test. d - f Tumor-derived single-cell suspensions were analyzed by flow cytometry. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n = 6 mice, mean +- SEM). Statistical analysis by two-tailed Student's t -test. e , f Analysis for e CD4 + /CD8 + T cells or f myeloid cells ( n = 6 mice, mean +- SEM). Statistical analysis by two-tailed Student's t -test. g , h Tissue lysates from normal brains and tumors were subjected to ELISA analysis for g IL-10 and h TGF-beta expression (mean +- SEM, n = 4 mice for IL-6-DeltaEC GBM group and n = 3 mice for other groups). Statistical analysis by two-way ANOVA with Sidak's test. Source data are provided as a Source data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14979_41467_2021_23832_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 IL-6 neutralization enhances T-cell infiltration into GBM tumors and improves animal survival but does not sensitize tumor to immune checkpoint blockade. GBM was induced in WT B6 mice, followed by injection with control IgG, anti-IL-6 antibody (Ab), immune checkpoint inhibitors (ICIs), or ICIs plus anti-IL-6 Ab. a Schematic approach. b , c Survival and tumor growth analyses ( n = 8-12 mice, specific n numbers are shown in the figure). b Mouse survival was monitored for 60 days and subjected to two-sided log-rank Mantel-Cox analysis. MS, median survival. c Tumor volume was analyzed by bioluminescence imaging during days 13-23 (mean +- SEM). Statistical analysis by two-way ANOVA with Dunnett's test. d - g Tumors were excised 2 days after treatment. Tumor-derived single-cell suspensions were stained with antibodies against CD45, d CD3, e CD11b, f CD4, CD8, CD3, and g Ki67, IFN-gamma, and CD69, followed by flow cytometry analyses. d Analysis for CD3 + T cells. Left, representative cell sortings. Right, quantified results ( n = 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher's LSD test. e - g Quantified results for immune cells ( n = 6 mice, mean +- SEM). Statistical analysis by one-way ANOVA with Fisher's LSD test. Source data are provided as a Source data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15187_fcell-09-672032-g005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 5 Increased apoptosis and aggregation of immune cells in the liver of LAMTOR1 MKO mice. (A) Flow cytometry results (presented with same cell amount). (B) Percentage of dead cells. (C) Percentage of CD45 - cells, CD45 + cells, and the ratio of CD45 + /CD45 - cells within live cells. (D) Percentage of macrophages (F4/80 + CD11b - ), monocytes (F4/80 - CD11b + ), and sum of macrophages and monocytes within live cells. (E) Percentage of M1- and M2-like macrophages in live cells. n = 4. ** P < 0.01 vs. WT. KO, myeloid-specific knockout mice; Mo, monocytes; Mphi, macrophages; WT, wild-type.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 8 CRT mediates efferocytosis of MSC-derived apoVs to modulate T2D liver macrophages in vivo. (a) Representative immunofluorescent (IF) staining images of F4/80 (green) and CD11b (green) in the liver, counterstained by Hoechst (blue). DIO, mice with diet-induced obesity; si-NC-apoV, DIO mice treated by apoVs derived from MSCs transfected by siRNA-negative control; si- CRT -apoV, DIO mice treated by apoVs derived from MSCs transfected by siRNA- CRT . Scale bars, 50 mum. (b) Flow cytometric analysis and the corresponding quantification of the percentages of KCs and MoMFs in hepatic CD45 + cells. KCs, Kupffer cells; MoMFs, monocyte-derived macrophages. N = 5-6 per group. (c) Representative IF staining images of chemokine (C-C motif) ligand 2 (CCL2) (red) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum. (d and e) ELISA analysis of CCL2 in liver lysate (d) and serum (e). N = 6 per group. (f and g) Representative IF staining images of tumor necrosis factor-alpha (TNF-alpha) (red) and CD206 (green) in the liver, counterstained by Hoechst (blue), and the corresponding quantification of fold changes over the DIO group. Scale bars, 50 mum. N = 5-6 per group. (h and i) Quantitative real time polymerase chain reaction (qRT-PCR) analysis of mRNA expression levels of Tnf (h) and interleukin 10 ( Il10 ) (i) in the liver, normalized to beta-actin ( Actb ), and quantification of fold changes over the DIO group. N = 5 per group. (j and k) Enzyme-linked immunosorbent as</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15175_JEV2-10-e12109-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 3 Efferocytosis of MSC-derived apoVs by liver macrophages alleviates macrophage infiltration in the type 2 diabetes (T2D) liver. (a) Representative confocal microscopy images showing distribution of PKH26-labeled apoVs (red) in the liver, counterstained by Hoechst (blue). After removal of unbound PKH, the stained apoVs were resuspended in PBS and underwent centrifugation, after which the supernatant was used as the negative control (NC) and injected. Scale bars, 50 mum. (b) Representative confocal microscopy images showing uptake of apoVs (red) by macrophages (green) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum in low magnification images and 25 mum in high magnification images. (c) Flow cytometric analysis showing the uptake of apoVs by macrophages in the liver. KCs, Kupffer cells; MoMFs, monocyte-derived macrophages. (d) Representative immunofluorescent (IF) staining images of F4/80 (green) and CD11b (green) in the liver, counterstained by Hoechst (blue). Ctrl, control mice; DIO, mice with diet-induced obesity; apoV, DIO mice treated by apoVs. Scale bars, 50 mum. (e) Flow cytometric analysis and the corresponding quantification of the percentages of KCs and MoMFs in hepatic CD45 + cells. N = 6 per group. (f) Representative IF staining images of chemokine (C-C motif) ligand 2 (CCL2) (red) in the liver, counterstained by Hoechst (blue). Scale bars, 50 mum. (g) Enzyme-linked immunosorbent assay (ELISA) analysis of CCL2 in liver lysate and serum. N</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15189_gr2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 Mice harboring a conditional deletion of Nox4 in monocyte-derived macrophages are protected from pulmonary fibrosis . WT mice were exposed to chrysotile and BAL was harvested on day 0, 5, 10, 15, and 21. A , representative flow cytometry plots of resident alveolar macrophages (RAM, CD45 + CD11b +/ - Ly6G - CD64 + Ly6c - Siglec F hi ) and monocyte-derived macrophages (MDM, CD45 + CD11b +/ - Ly6G - CD64 + Ly6c - Siglec F low ). Number of flow sorted B , RAMs ( n = 4-5) and C , MDMs ( n = 4-5). D , CCL2 levels in BAL fluid ( n = 4-5). WT and Nox4 -/- Lyz2-cre mice were exposed to MMVF or chrysotile. BAL was performed on day 21. E , Representative flow cytometry plots of RAMs and MDMs. Number of flow sorted F , RAMs ( n = 5) and G , MDMs ( n = 5). H , CCL2 levels in BAL fluid ( n = 5). I , Caspase-3 activity in RAMs ( n = 5) and J , MDMs ( n = 5). ** p < 0.001; *** p < 0.0001. Values shown as mean +- SEM. One-way ANOVA followed by Tukey's multiple comparison test was utilized.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12875_gr3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 DCs uptake preference of intradermal injected DiO-loaded PLGA nanoparticles in IMQ-induced psoriasis-like mice. (A) Representative immunofluorescence staining of psoriasis-like mice skin section (a) that intradermally injected with DiO-loaded PLGA nanoparticles (after injection for 4 h), enlarged in (b). (B) Representative immunofluorescence staining of SDLN from psoriasis-like mice that intradermally injected with DiO-loaded PLGA nanoparticles (after injection for 1 h), enlarged in (b). Scale bar: 250 mum (enlargement: 50 mum). Blue: nucleus, green: DiO, red: anti-CD11c. (C) Flow cytometry gating strategy to identify and analyze DCs populations in different lymphoid organs. Gating is shown in one representative data of mice at 1 h exposure after treated with S-NPs. After the initial live gating in a forward scatter (FSC) and side scatter (SSC) plot, particle-positive cells were first gated. Among them, DCs from SDLN and spleens were gated in a CD45 versus CD11c plot. (D) PBS controls and different sizes of DiO-loaded PLGA nanoparticles were intradermally administrated in IMQ-induced psoriasis-like mice, and the single-cell suspensions obtained from lymphoid organs were analyzed at 1, 4, 8, 24, and 48 h after particle exposure. Among particle-positive subset in SDLN (D) and spleens (E), comparison between S-NPs and L-NPs detected in these tissues were made. Data are presented as mean +- SEM ( n = 6), ** P < 0.01, * P < 0.05. Figure 3</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15174_gr1.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 BM niche populations identified with current markers (A) Schematic figure of the experimental design depicting stromal components isolated from the BM of NSG mice carrying specific fluorescent reporters. FACS populations were analyzed by RNA-seq. CD31 n = 7; Nes high n = 4; Nes low n = 5; Ng2 n = 3; Osx n = 5; Col low n = 4; Col high n = 5. (B) 3D PCA analysis showing similarities in expression profiles between different stromal components in healthy mice. Each dot represents an experimental replicate. (C) Flow-cytometry analysis of CD45 - Ter119 - BM cells derived from depicted mice showing overlap between markers associated to niche components. (D) Correlation matrix showing similarities between different stromal components in healthy mice. See also Figure S1 .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15173_395_2021_869_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Flow cytometry of aortic lysates and whole blood demonstrates leukocyte extravasation into the aortic endothelium by noise and prevention by LysM + cell ablation. Flow cytometry and representative plots in aortic lysates show an increase in count following noise exposure and a reduction in count in all leukocytes ( a ) as well as innate immune leukocytes ( b ). Specifically, monocytes ( c ) and macrophages ( d ) were reduced below baseline control counts and no increase was found in the aorta following both noise exposure and LysM + cell ablation. e All immune cell subsets were found decreased in whole blood of noise-exposed CTR mice or in the DTX-treated groups. Data points are measurements from individual animals; one-way ANOVA with Tukey's multiple comparison test ( a - e ). * P < 0.05 vs. Control; # P < 0.05 vs. Noise; $ P < 0.05 vs. DTX, + P < 0.05 vs. DTX + Noise</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15185_cells-10-00940-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Immune organ weight and cell profiling at day 30 post-HU. ( a ) Thymus and ( b ) spleen weights normalized to body weights at day 30 post-HU. ( c - f ) Results from flow cytometry of whole blood collected from mice at day 30 post-HU. ( c ) Neutrophil within leukocytes population percentages (%, Ly6g+CD11b+/CD45+), ( d ) Lymphocytes within leukocyte population percentage (%, CD11b-/CD45+), ( e ) Neutrophil to lymphocyte ratio (NLR), and ( f ) Total monocyte to leukocyte population percentage (%, CD11b+/CD45+). NL Sham ( n = 12), NL PAD ( n = 12), HU Sham ( n = 11), and HU PAD ( n = 9). * Statistically significant at p < 0.05 by one-way ANOVA with Tukey post-hoc test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing IFNgamma, mTOR, and S6K are expressed as the mean +- S.D. * p < 0.05; ** p < 0.01; *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing T-bet and Eomesodermin are expressed as the mean +- S.D. * p < 0.05; ** p < 0.01; *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15183_41514_2021_58_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 NAD+ declines with age in bone marrow osteoblastic cells. a Protein levels by western blot (left) and relative quantification (right) of band intensity in bone marrow stromal cells from 6- and 24-month-old C57BL/6 female mice cultured with ascorbic acid and beta-glycerophosphate for 5 days; each lane represents one mouse ( n = 4/group). b Relative cellular NAD + levels in cultured osteoblastic cells pooled from 5 mice/group (triplicates of pooled cultures). AFU arbitrary fluorescence units. c , d mRNA levels by qRT-PCR in ( c ) CD45 - cells freshly isolated from 6- and 24-month-old C57BL/6 female mice ( n = 5/group) and d cultured cells described in a . e Protein levels in cultured stromal cells described in a . Bar graphs represent mean +- SD, data analyzed by Student's t -test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15061_mmcfigs2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Fig. S2. OVX leads to decreased bone mass and osteogenic differentiation defects in BMMSCs. (A) Micro-CT analysis of trabecular bone mass in the femurs. (B) Quantitative analysis of bone mineral density (BMD), bone volume to tissue volume (BV/TV), trabecular number (Tb. N) and trabecular separation (Tb. Sp). (C) Flow cytometry analysis of ex vivo expanded BMMSCs revealed positive expression of CD105 and CD29, and negative expression of CD11b, CD45 and CD34. (D) Real-time PCR was performed to detect mRNA expression of ALP and Runx2 on day 5 after osteogenic induction. (E) Alizarin red staining and quantification of mineralized nodules were performed on day 21 after osteogenic induction. (F) Western blotting analysis and quantification of the osteogenic-related proteins ALP and Runx2 on day 10 after osteogenic induction. n = 6 per group. Data are presented as mean +- SD; *P < 0.05; **P < 0.01 by unpaired Student's t -test. Fig. 2</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15157_urn-x-wiley-08840431-media-jbmr4282-jbmr4282-fig-0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">3 Fig CXCL12 is functionally important for maintaining stromal-hematopoietic coupling. ( A ) Conceptual diagram of CXCL12 conditional deletion experiment. Col2a1-cre ; Cxcl12 GFP/+ ; R26R tdTomato mice were mated with Cxcl12 fl/fl mice to generate Col2a1-cre ; Cxcl12 GFP/fl ; R26R tdTomato (Col2a1-CXCL12 cKO) and Cxcl12 GFP/fl ; R26R tdTomato (Control) mice. In Col2a1-CXCL12 cKO mice, Cxcl12-GFP + cells lose functional CXCL12 expression but still express GFP in a Cxcl12 promoter/enhancer-dependent manner. ( B ) CD45 staining of Control (left panels) and Col2a1-CXCL12 cKO (right panels) bone marrow. Dotted area = magnified view of Cxcl12 -GFP + reticular stromal cells and neighboring CD45 + hematopoietic cells. Green = Cxcl12-GFP; red = tdTomato; magenta = CD45-Alexa647; gray = DAPI. Scale bar = 10 mum. n = 4 mice per group. ( C ) Flow cytometry analysis of Control and Col2a1-CXCL12 cKO bone marrow cells. The percentage of CD45 + cells in total bone marrow cells (center) and CD45 + GFP + cells in whole GFP + fraction (right). n = 4 mice per group. Two-tailed, Mann-Whitney U test. All data are presented as mean +- SD.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12873_SN-ENUJ210063F005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 5. Treatment with anti-CCL3 FANA ASOs reduced CD11b+ macrophages at the lesion site. A , B. Flow cytometry 1 d after SCI in anti-CCL3-FANA ASO and control-treated animals did not reveal a significant difference in Gr-1+ neutrophils. Numbers were assessed in the CD11b+CD45+ gated cell population. The negative control was stained with CD11b+CD45+ in absence of the Gr-1 antibody. A , Representative flow cytometry images. B , Quantification of CD11b+CD45+Gr-1+ neutrophils. C , Representative images of CD11b+ macrophages/microglia, GFAP+ astrocytes, and SMI-32+ profiles as indicators of axonal damage adjacent to the lesion epicenter in anti-CCL3-FANA ASO and control-treated animals. The schematic indicates the location of the quantified region (square) next to the lesion (red circle). D , Quantification revealed a significant reduction of CD11b+ macrophages/microglia in the anti-CCL3-FANA ASO treatment group, while neither astrocytes nor indicators of axonal damage were different between groups; n = 5/group, data points are represented as mean +- SEM; * p = 0.01. Scale bars: 80 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ) Flow cytometry analysis for immunophenotyping showed that MSCs, in passages 7-8, were positive for CD 29 (98.8%), SCA-1 (98.2%), CD 44 (6.02%), CD 90 (4.18%), and CD 105 (4.97%), and negative for CD34 (0.49%), CD 45 (1.37%), and CD 31 (0.05%).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g017.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells in the eye which causes stable YFP expression under the control of the Rosa26 promotor. Flow cytometric measurement of the persistence of YFP + retinal microglia (rMG), cliliary body (cb) MPhi, and corneal (c) MPhi in adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Doublets and dead cells were excluded by FSC-W and viability dye. Representative flow cytometry plots from two independent experiments with at least six mice are displayed. Kinetics of YFP labeling in macrophages of the healthy eye. Symbols represent means +- s.e.m. rMG are shown as squares (2 weeks: n = 10 mice, 12 weeks: n = 9 mice, 24 weeks: n = 12 mice, Kruskal-Wallis ns P > 0.05), cbMPhi are depicted as triangles (2 weeks: n = 4 samples from eight mice, 12 weeks: n = 3 samples from six mice, 24 weeks: n = 6 samples from twelve mice, Kruskal-Wallis ns P > 0.05) and cMPhi as circles (2 weeks: n = 6 mice, 12 weeks: n = 8 mice, 24 weeks: n = 12 mice, one-way ANOVA *** P < 0.0001). Data were obtained from two (cMPhi: 2 weeks, cbMPhi: 2 and 12 weeks), three (rMG: 2 weeks, cbMPhi: 24 weeks), or four (</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15171_EMBJ-40-e105123-g009.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 Prenatal source of eye macrophages Left: Creation of Acta1 GFP/+ :Acta1 +/+ bone marrow chimeras. Right: Donor-derived GFP + CD45 lo CD11b + were detectable in the recipient retina by flow cytometry 20 weeks after bone marrow reconstitution. FACS Plots are representative for five animals from one experiment. Quantification of GFP + cells among CD45 + CD11b + retinal microglia by flow cytometry. Data are presented as mean +- s.e.m. One symbol represents one mouse. Typical retinal flat mount from Acta1 GFP/+ :Acta1 +/+ bone marrow chimeras 20 weeks after reconstitution. Donor-derived GFP + Iba1 + cells (arrow) and GFP - Iba1 + resident microglia (asterisks) are shown. Pictures are representative for three animals from one experiment. Scale bars represent 50 um. Microscopy-based quantification of GFP + Iba1 + retinal microglia in the inner (IPL) and outer plexiform layer (OPL). One symbol represents one mouse. Data are presented as mean +- s.e.m. Scheme of a fate mapping experiment using Cx3cr1 CreERT2 :Rosa26-YFP female mice. Tamoxifen (TAM) and progesterone injection were performed at embryonic day 9.0 (E9.0). Mice were subsequently evaluated at postnatal day 0 (P0). Administration of TAM leads to intra-embryonic excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells which causes stable and steady YFP expression under the control of the Rosa26 promotor. Direct fluorescence microscopic visualization for YFP (green), the macrophage</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15161_urn-x-wiley-02614189-media-embj2020105123-embj2020105123-fig-0004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">4 Figure Contribution of definitive hematopoiesis to eye macrophage subsets during steady-state Scheme of a fate mapping experiment using adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Tamoxifen (TAM) injection was performed at postnatal day 42 (P42). Mice were evaluated at 2, 12, and 24 weeks post-injections. Administration of TAM leads to the excision of a stop sequence flanked by loxP sites (gray triangles) in Cx3cr1 expressing cells in the eye which causes stable YFP expression under the control of the Rosa26 promotor. Flow cytometric measurement of the persistence of YFP + retinal microglia (rMG), cliliary body (cb) MPhi, and corneal (c) MPhi in adult Cx3cr1 CreERT2 :Rosa26-YFP mice. Doublets and dead cells were excluded by FSC-W and viability dye. Representative flow cytometry plots from two independent experiments with at least six mice are displayed. Kinetics of YFP labeling in macrophages of the healthy eye. Symbols represent means +- s.e.m. rMG are shown as squares (2 weeks: n = 10 mice, 12 weeks: n = 9 mice, 24 weeks: n = 12 mice, Kruskal-Wallis ns P > 0.05), cbMPhi are depicted as triangles (2 weeks: n = 4 samples from eight mice, 12 weeks: n = 3 samples from six mice, 24 weeks: n = 6 samples from twelve mice, Kruskal-Wallis ns P > 0.05) and cMPhi as circles (2 weeks: n = 6 mice, 12 weeks: n = 8 mice, 24 weeks: n = 12 mice, one-way ANOVA *** P < 0.0001). Data were obtained from two (cMPhi: 2 weeks, cbMPhi: 2 and 12 weeks), three (rMG: 2 weeks, cbMPhi: 24 weeks), or four (</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14831_12974_2021_2083_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 a Gating strategy for determination of Treg frequency (i) = initial population, (ii) = singlets, (iii) = live cells, (iv) = lymphocytes, (v) = CD45hi cells, (vi) = CD3+ cells (T cells), (vii) = CD4+ T cells vs. CD8+ T cells, (viii) = CD4+ CD25+ FoxP3+ cells (quadrant in red) designated Tregs. b Flow cytometric analysis of splenic Treg frequencies in a mouse model of brain ischaemia. 15-17-week-old male, C57BL/6 mice underwent permanent middle cerebral artery occlusion (pMCAO). At 2, 24, and 48 h post-ischaemia, mice received either saline or fingolimod (0.5 mg/kg or 1 mg/kg) by intraperitoneal injection ( n = 16 mice per group). Age-matched mice who had not undergone pMCAO acted as immunological controls ( n = 8). At 7 days post-ischaemia, flow cytometry was used to determine the frequency of splenic Treg cells. All gates were determined by both negative cells and fluorescence minus one controls</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9905_fimmu-11-607564-g010.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 10 F240B inhibits the NLRP3 inflammasome and inflammation in a mouse model of gouty inflammation. (A) Neutrophil and peritoneal lavage cells influx were quantified by Gr-1 and CD45 staining and cell count, respectively. (B, C) The expression levels of IL-1beta, active caspase-1, IL-6 and MCP-1 in the peritoneal lavage fluids were measured by ELISA. The ELISA data expressed as mean +- SD of three separate experiments. *, ** and *** indicate a significant difference at the level of p < 0.05, p < 0.01 and p < 0.001, respectively, compared to MSU crystal-injected mice. ### indicates a significant difference at the level of p < 0.001 compared to control mice.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9906_41541_2020_270_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Bp-infected BALB/c mice develop Th17 T RM cells in the nose. Six-week-old C57BL/6 mice and BALB/c mice were infected with 10 6 CFU of B1917GR. Nasal immune cells were collected at indicated time points post challenge (D0-D28). Ten minutes before euthanasia, mice were intravenously injected with anti-CD45-PE antibody enabling us to discriminate T RM cells from circulating cells. T RM cells express CD44, CD69, and/or CD103. Cell activation was assessed by nonspecific ex vivo stimulation and intracellular staining of IL-17 and IFN-gamma. Cells were fixed and permeabilized to perform intracellular staining of IL-17 and IFN-gamma. Numbers indicate percentages of events in each square. a Representative graph showing the accumulation of CD103 + CD44 + T RM cells in the nose of BALB/c mice at indicated time points after Bp challenge. b Representative graph comparing the pattern of expression of CD44 (left panels) and CD103 (right panels) in the nose of C57BL/6 (black) and BALB/c mice (gray) at indicated time points after Bp challenge. Numbers indicate mean fluorescence intensities and dotted lines indicate the cut-off between positive and negative cells. c Representative graph showing the proportion of IL-17- and/or IFN-gamma-producing CD4 + T RM cells in the nose of C57BL/6 (left panels) and BALB/c mice (right panels) at indicated time points after Bp challenge. Numbers indicate percentages of events in each square.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9861_gr4_lrg.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 mum. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 mum. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were signifi</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9861_gr3_lrg.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 A group of immature aberrant neutrophils emerged in coronavirus-infected mice (A) Immunohistochemical analysis of the location and expression of S100A8 in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi. The S100A8 + cells in the lungs of mice infected with coronavirus were increased significantly. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 mum. (B) Flow cytometry analysis of neutrophils in lungs from mice infected with SARS-CoV-2 and MHV at 5 dpi. Control group means mice treated with vehicle. Gate P1 shows the conventional neutrophils (CD45 + CD11b + Ly6G high ), and Gate P2 shows the pathologic aberrant neutrophils (CD45 + CD11b + Ly6G variable ). Aberrant neutrophils (P2) in the lungs of mice infected with coronavirus were significantly increased. n = 3. (C) Flow cytometry analysis of neutrophils in lungs of mice challenged with IAV, EMCV, HSV-1, and LPS at 5 dpi. The results showed that these treatments did not induce an increase in aberrant neutrophils. n = 3. (D) Flow cytometry analysis of neutrophils in bone marrow from mice infected with SARS-CoV-2 and MHV at 5 dpi. n = 3. (E) qRT-PCR-analyzed related gene expression of aberrant neutrophils in bone marrow of mice infected with MHV at 5 dpi and identified the differentiated types of aberrant neutrophils. n = 3. *** p < 0.001. Error bars, SD.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15184_MUS-63-600-g005.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">FIGURE 1 Immune cell proportions in skeletal muscle and blood. A, Number of mononuclear cells in skeletal muscle. B, Number of CD11b + F4/80 + cells (macrophages), CD11b + Ly-6G + cells (neutrophils), and CD45 + CD3e + cells (T cells) in skeletal muscle. C, Number of CD11b + F4/80 + , CD11b + Ly-6G + , and CD45 + CD3e + cells in blood</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15182_fnut-07-583186-g0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 SP reduces the total B cell population and controls B cell subset populations in old mice. (A) Splenic cells were stained with anti-CD19-FITC. In the right-hand dot plots, CD3+ T cells were gated electronically. Representative data from young and old mice are shown. The numbers inside the plots represent the percentage of each cell population (mean +- SEM; n = 3). Fluorescence scales are logarithmic. (B) The concentration of IL-6 in serum from experimental mice, as determined by ELISA at weeks 0, 2, 4, and 6 (mean +- SEM; n = 4). (C) Cells were stained with anti-CD19-FITC and anti-CD45R-PE. The B1REL and B2 cell compartments were identified as CD19+ CD45Rlow (B1REL, left gate) and CD19+ CD45R+ (B2, right gate), respectively. Representative data from young and old mice are shown. The numbers inside the plots represent the percentage of each cell population (mean +- SEM; n = 3). The fluorescence scales are logarithmic. Statistical significance was determined using one-way ANOVA followed by Tukey's post-hoc test. Datasets denoted by different letters are significantly different ( p < 0.05).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Increased human and mouse blood and heart EOS count after MI. a EOS count per liter blood in men with ( n = 345) and without ( n = 5,519) AMI ( P = 3.3 x 10E-9). b . Spearman correlation between LV EF and blood EOS count among a subgroup of 482 men who had the echocardiography results available ( r = -0.122, P = 0.013). c . FACS strategy to analyze heart and blood EOS from WT mice at 1-day post-MI. d Representative FACS images of heart EOS from WT sham at 1-day after operation. EOS-deficient DeltadblGATA sham mice served as negative control. e FACS analysis of blood EOS in WT sham and MI mice at 1-day after surgery. Representative FACS images are shown to the left. f . FACS analysis determined heart EOS count or percentage among total CD45 + cells in WT MI and sham mice at different days after surgery. g , h Anti-mouse GFP antibody detection of GFP-positive EOS in the infarct, border, and remote regions from eoCRE +/- GFP +/- mice at 1-day post-MI. Representative images are shown to the left ( g ). Heart sections from sham-operated eoCRE +/- GFP +/- mice served as experimental control ( h ). Scale: 30 um, inset: 15 um. i . RT-PCR determined the mRNA levels of EOS relevant chemokines in heart tissues from WT MI and sham mice at 1-day after surgery. Data are mean +- SEM. The numbers of patients ( a ) and mice ( e - g , i ) in each group, and P values ( a , e - g , i ) are indicated, Student's t-test ( a ), non-parametric Mann-Whitney U test followed by Bonferroni correct</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19138_41467_2020_19297_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 3 EOS deficiency affects heart acute immune cell accumulation post-MI. a FACS quantification of different immune cells in percentage of total CD45 + cells at different time points post-MI. b CD45 + CD11b + Gr-1 + neutrophils at 1-day after surgery. c RT-PCR determined the mRNA levels of neutrophil relevant chemokines (Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcl7) in heart from WT and DeltadblGATA mice at 1-day post-MI. d, e CD45 + CD11b + Ly6C hi and CD45 + CD11b + Ly6C lo monocytes at 3 days ( d ) and 5 days ( e ) after surgery. f CD45 + CD11c + MHC-II + dendritic cells at 5 days after surgery. g CD45 + CD4 + CD8 - and CD4 - CD8 + T cells at 7 days after surgery. h FACS gating strategy. Data are mean +- SEM. The numbers of mice in each experimental group and P values are indicated, one-way ANOVA test ( b , d - g ) and non-parametric Mann-Whitney U test ( c ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14944_urn-x-wiley-08941491-media-glia23948-glia23948-fig-0001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">1 FIGURE The effects of postmortem delay (PMD) on viable fluorescence-activated cell sorting (FACS)-sorted mouse microglia numbers and RNA quality. (a) FACS plots depicting the sorting strategy of DAPI neg Ly6C neg CD11b high CD45 int microglia and the PMD induced decrease in the percentage of DAPI neg microglia in gate R5. (b) Dot plot depicting the number of DAPI neg microglia sorted from entire mouse brains at different PMD times ( n = 4 mice per PMD). (c) Dot plot depicting RIN values of RNA extracted from sorted DAPI neg Ly6C neg CD11b high CD45 int microglia at different PMD times ( n = 4 mice per PMD). A one-way ANOVA followed by a Bonferroni correction for multiple comparisons was performed to assess significance. **, p < .01; ***, p < .001</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig2.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2. Immune cell profiles in axotomized DRGs. ( A ) Representative images of L4 DRG cross sections from naive mice, d1, d3, and d7 post-SNC. Macrophages were stained with anti-Iba1 and anti-F4/80. Neurons were stained with anti-NFH. Scale bar, 50 um. ( B ) Quantification of granulocytes per DRG detected by flow cytometry. For flow cytometry of DRGs, naive mice (n = 14 biological replicates), d1 (n = 3), d3 (n = 5), and d7 (n = 12) post-SNC mice were used. Granulocytes (CD45 + , CD11b + , Ly6G + ) per DRG are shown. ( C ) Quantification of Mo/Mac (CD45 + , CD11b + , CD11c - , Ly6G - ) per DRG. ( D ) Quantification of MoDC (CD45 + , CD11b + , CD11c + , Ly6G - ) per DRG. ( E ) Quantification of cDC (CD45 + , CD11b - , CD11c + , Ly6G - ) per DRG. ( F ) Quantification of lymphocytes (CD45+, CD11b - ) per DRG. ( G ) Composition of CD45 + leukocytes in lumbar DRGs identified by flow cytometry. Flow data are represented as mean cell number +- SEM. Each data point represents L3-L5 DRGs pooled from three to four animals (18-24 DRGs), biological replicates, n = 3-14. Statistical analysis was performed in GraphPad Prism (v7) using one-way or two-way ANOVA with correction for multiple comparisons with Tukey's post-hoc test. For B-F, unpaired two-tailed t-test with Welch's correction. A p value < 0.05 (*) was considered significant. p<0.01 (**), p<0.001 (***), and p<0.0001 (****). ( H ) Western blots analysis of DRGs and sciatic nerves (SNs) prepared from sham operated mice and mice a</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig6.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 6. Macrophage subpopulation in the injured nerve are functionally distinct and localize to specific sites. ( A-E ) Feature plots of Adgre1 (F4/80), Aif1 (Iba1), Cd68 (Scavenger receptor class D) , Cx3cr1 (Fractalkine receptor), and CD209a (DC-SIGN) expression in the d3 post-SNC nerve. ( F ) scRNAseq dot plot analysis of transcription regulators (TRs) enriched in leukocytes. Average gene expression and percentage of cells expressing the TR are shown. ( G ) Violin plot of Ly6c2 (Ly6C) expression in immune cells of the d3 post-SNC nerve. ( H-K ) Flow cytometric analysis of sciatic nerve Mo/Mac (CD45 + , CD11b + , Ly6G - , CD11c - ) in naive mice, d1, d3, and d7 post-SNC mice. Mo/Mac maturation was assessed by Ly6C surface staining. ( L, M ) Quantification of Ly6C distribution on Mo/Mac in naive nerves and at different post-SNC time points (n = 11 biological replicates per time point); ( L ) Percentile of Ly6C - , Ly6C int , and Ly6C hi Mo/Mac and ( M ) number of Ly6C - , Ly6C int , and Ly6C hi Mo/Mac. Flow data are represented as mean +- SEM. Statistical analysis was performed in GraphPad Prism (v7) using one-way or two-way ANOVA with correction for multiple comparisons with Tukey's post-hoc test. A p value < 0.05 (*) was considered significant. p<0.01 (**), p<0.001 (***), and p<0.0001 (****). ( N ) Feature plot showing Arg1 (Arginase-1) expression in the 3d post-SNC nerve. ( O-Q ) Longitudinal sciatic nerve sections of Arg1-YFP reporter mice, from naive mice ( O ), d3 (</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9859_elife-60223-fig3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3. Sciatic nerve injury triggers massive accumulation of hematogenous leukocytes in the injured nerve but not axotomized DRGs. ( A ) Parbiosis complex of a wildtype (WT) and a tdTomato (tdTom) mouse. Mice were surgically paired at postnatal day 56. The timeline of the experiment is shown. ( B ) Flow cytometric analysis of sciatic nerve trunks collected from non-parabiotic (single) tdTom mice, WT parabionts, and tdTom parabionts. Dotplot of live (CD11b + , tdTom + ) cells in the d3 post-SNC nerve. ( C ) Quantification of tdTom + myeloid cells in the 3d injured nerve of WT single mice (WT-S), WT parabiont (WT-para), tdTom parabiont (tdTom-para), and tdTom single (tdTom-S) mice. The fraction of tdTom + myeloid cells (CD45 + , CD11b + ), MoDC (CD45 + , CD11b + , CD11c + , Ly6G - ), and Mo/Mac (CD45 + , CD11b + , CD11c - , Ly6G - ) is shown. For quantification of tdTom + immune cells, nerves from the WT parabiont and the tdTom parabiont were harvested separately (three mice per data point) with n = 2-3 biological replicates. Flow data are represented as fraction of tdTom + cells +- SEM. Statistical analysis was performed in GraphPad Prism (v8) using one-way ANOVA with correction for multiple comparisons with Tukey's post-hoc test. p value of < 0.001 (***) and p<0.0001 (****). ( D ) Longitudinal sciatic nerves sections of the WT parabiont at d7 post-SNC. The nerve crush site is marked with a white dotted line, proximal is to the left, distal to the right. Anti-F4/80 (green)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14973_13287_2020_2014_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Characterization of murine BMMSCs. a , b Flow cytometric analysis of the surface markers showed positive expression of CD29, CD90, CD105, CD146, and Sca-1, and negative expression of hematopoietic markers CD11b, CD34, and CD45. c Representative image of colony formation of murine BMMSCs. d Representative image of Oil Red O staining of murine BMMSCs. e Representative image of ALP staining of murine BMMSCs. f Representative image of Alizarin red staining of murine BMMSCs. Scale bar, 500 mum</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15081_41467_2020_19593_Fig9_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 9 The NOTCH3 enhancer promotes tumor-initiating activity of NRF2-activated NSCLCs. a Oncosphere growth of DeltaN3U and wild-type (WT) H460 cells (left panel). Scale bars indicate 100 mum. Viable cells were counted after trypsinization (right panel). Average cell numbers and SD from four independent experiments are shown. Comparison was made between two cell groups; WT and each mutant clone. Two-sided Student's t test was performed. * p < 0.05. b Spheroid growth of DeltaN3U and WT H460 cells (left panels). Scale bars indicate 100 mum. Cell numbers were estimated using a cell counting kit on day 4 (right panel). Average cell numbers and SD from six independent experiments are shown. The average number of WT H460 cells was set as 100%. Two-sided Student's t test was performed. n.s. : not significant. c Xenograft experiment of DeltaN3U and WT H460 cells ( n = 9 each; number of xenograft tumors). A photograph shows xenograft tumors at the time of tumor weight measurement on day 15. Horizontal bars indicate the median tumor weight (middle panel). Data are presented as mean + SEM (left panel). Two-sided Wilcoxon rank sum test was performed. * p < 0.05. d Xenograft experiment of DeltaN3U H460 Clone 2-2 cells with LacZ and N3ICD ( n = 12 each; number of xenograft tumors). A photograph shows xenograft tumors at the time of tumor weight measurement on day 18. Horizontal bars indicate the median tumor weight (middle panel). Data are presented as mean + SEM (left panel). Two-sided Wi</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9904_fnmol-13-00149-g0002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 Flow cytometry allows for a relative quantification of VGLUT1 immunoreactivity in microglia from both the adult and the developing mouse brain. (A) FACS plot displaying the gates for both microglia (CD11b + CD45 lo population) and brain's non-myeloid cells (CD11b - CD45 - population). (B) FACS plot showing VGLUT1 immunoreactivity in both microglia and brain's non-myeloid cells. (C) Microglia from VGLUT1-stained samples exhibit a positive staining, as compared to isotype control. (D) Percentage of the VGLUT1-positive microglia, fluorescence of the isotype control is used as baseline ( N = 6 mice, pooled data from two independent experiments). (E) FACS plot displaying both microglia (CD11b + CD45 lo population) and CD45hi MPs (CD11b + CD45 hi population). (F) Fluorescence peak of the VGLUT1 staining in CD45 hi MPs. (F1) Fluorescence peak of the VGLUT1 staining in microglia (anti-VGLUT1-PE, Merck Millipore FCMAB335PE, clone 3C10.2). (G) Fluorescence peak of the Synaptophysin staining in CD45 hi MPs. (G1) Fluorescence peak of the Synaptophysin staining in microglia. (H) n-MEAN-FLUORESCENCE-INTENSITY (MFI) for VGLUT1 and Synaptophysin in both microglia and CD45 hi MPs (VGLUT1 N = 6 mice per group, pooled data from two independent experiments; Mann-Whitney U -test; ** p = 0.002. Synaptophysin N = 4 mice per group, data from a single experiment; Mann-Whitney U -test unpaired; * p = 0.029). (I) Fluorescence peak of the VGLUT1 staining in microglia using an alternative antibo</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9904_Image_3.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig8_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 8 Exosomal miR-21 counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H&E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). WT-EXOT transplantation of exosomes derived from wild-type mesenchymal stem cells (MSCs) after MNU injection, miR-21 -/- -EXOT transplantation of exosomes derived from miR-21-deficient MSCs after MNU injection, GCL ganglion cell layer, INL inner nuclear layer, ONH optic nerve head. Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for area under curve (AUC). N = 3 per group. Representative scotopic electroretinography (ERG) waveforms ( C ) and the corresponding quantitative analyses of amplitude changes of a-wave ( D ) and b-wave ( E ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. Representative photopic ERG waveforms ( F ) and the corresponding quantitative analysis of b-wave amplitude changes ( G ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL, green) staining images of retinal tissues counterstained by Hoechst 33342 (blue) ( H ) and the corresponding quantitative analysis of percentages of TUNEL + cells over total ONL cells ( J ). Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test. N = 3 per group. Representative TUNEL (green) staining images of retinal tiss</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 6 miR-21 protects 661W cone photoreceptor cells against N -methyl- N -nitrosourea (MNU)-induced apoptosis and can be transferred from mesenchymal stem cells (MSCs). A Diagram demonstrating the experimental design for analyzing direct effects of miR-21 on 661W cells. NC negative control of miR-21 mimics. B Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of expression levels of miR-21 in 661W cells, normalized to Rnu6 . Ctrl control. * P < 0.05 by the Kruskal-Wallis test. N = 3 per group. Representative flow cytometric images showing death of 661W cone photoreceptor cells ( C ) and the corresponding quantitative analysis of percentages of apoptotic (Annexin V + PI - plus Annexin V + PI + ) 661W cells ( D ). 661W cells were treated with MNU with or without transfection of NC or miR-21 mimics. PI propidium iodide. * P < 0.05 by the Kruskal-Wallis test. N = 3 per group. E Diagram demonstrating the experimental design for analyzing indirect effects of MSCs on 661W cells. WT wild-type mice, miR-21 -/- , mice deficient for miR-21. Representative flow cytometric images showing death of 661W cone photoreceptor cells ( F ) and the corresponding quantitative analysis of percentages of apoptotic (Annexin V + PI - plus Annexin V + PI + ) 661W cells ( G ). MNU-treated 661W cells were co-cultured in the Transwell system with or without different MSCs. * P < 0.05 by the Kruskal-Wallis test. N = 3 per group. H qRT-PCR analysis of expression levels of miR-21 in MSCs, no</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 5 miR-21 deficiency aggravates N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration, which is restrained by transplantation of mesenchymal stem cell (MSC)-derived exosomes. A Tracing of CD63-EGFP plasmid-transfected MSCs (green, CD63) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. MSCT mesenchymal stem cell transplantation, INL inner nuclear layer, ONL outer nuclear layer. Scale bar = 50 mum. B Tracing of PKH26-labeled exosomes (red) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. EXOT exosomal transplantation, NC negative control, injection of EXO without staining. Scale bar = 50 mum. C Tracing of PKH26-labeled, MSC-derived exosomes (red) in 661W cone photoreceptor cells during in vitro treatment. 661W cells are demonstrated by beta-tubulin immunostaining for microtubules (green), counterstained by Hoechst 33342 (blue). NC negative control, treatment of EXO without staining. Scale bar = 10 mum. D Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of expression levels of multiple microRNAs in retina tissues, normalized to Rnu6 . Ctrl control. * P < 0.05 by the Mann-Whitney U test. N = 4 per group. Representative hematoxylin and eosin (H&E) staining images of retinal tissues ( E ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( F ). WT wild-type mice, miR-21 -/- mice deficient for m</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Intravitreal transplantation of mesenchymal stem cells (MSCs) and exosomes (EXO) ameliorates photoreceptor loss and retinal degeneration in the Phosphodiesterase 6b gene mutant ( Pde6b mut ) mouse model. A Schematic diagram demonstrating the study design of in vivo experiments on Pde6b mut retinal degeneration. Representative hematoxylin and eosin (H&E) staining images of retinal tissues ( B ) and the corresponding quantitative analysis of ONL thickness ( C ). MSCT mesenchymal stem cell transplantation, EXOT exosomal transplantation, GCL ganglion cell layer, ONH optic nerve head. Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for area under curve (AUC). N = 3 per group. Representative scotopic electroretinography (ERG) waveforms ( D ) and the corresponding quantitative analyses of amplitude changes of a-wave ( E ) and b-wave ( F ). * P < 0.05 by the Kruskal-Wallis tests. N = 3 per group. Representative photopic ERG waveforms ( G ) and the corresponding quantitative analysis of b-wave amplitude changes ( H ). * P < 0.05 by the Kruskal-Wallis tests. N = 3 per group. I Representative immunofluorescent (IF) staining images of retinal tissues showing cone photoreceptor bodies (white) counterstained by Hoechst 33342 (blue). Scale bars = 25 mum. Representative H&E staining images of retinal tissues ( J ) and the corresponding quantitative analysis of ONL thickness ( K ). Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for AUC. N = 3 per group. Represent</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Exosomes mediates therapeutic effects of mesenchymal stem cell transplantation (MSCT) on N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and retinal degeneration. Representative hematoxylin and eosin (H&E) staining images of retinal tissues ( A ) and the corresponding quantitative analysis of outer nuclear layer (ONL) thickness ( B ). Mice were injected with MNU with or without MSCT. GW4869, a neutral sphingomyelinase inhibitor for blocking exosome generation, which was used for MSC preconditioning before transplantation; GCL ganglion cell layer, INL inner nuclear layer, ONH optic nerve head. Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for area under curve (AUC). N = 3 per group. Representative scotopic electroretinography (ERG) waveforms ( C ) and the corresponding quantitative analyses of amplitude changes of a-wave ( D ) and b-wave ( E ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. Representative photopic ERG waveforms ( F ) and the corresponding quantitative analysis of b-wave amplitude changes ( G ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. Representative H&E staining images of retinal tissues ( H ) and the corresponding quantitative analysis of ONL thickness ( I ). Ctrl control, no MNU treatment, EXOT exosomal transplantation after MNU injection. Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for AUC. N = 3 per group. Representative scotopic ERG waveforms ( J ) and the corresponding quantitat</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15069_41418_2020_636_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Intravitreal transplantation of mesenchymal stem cells (MSCs) counteracts N -methyl- N -nitrosourea (MNU)-induced photoreceptor apoptosis and alleviates retinal degeneration. A Schematic diagram demonstrating the study design of in vivo experiments on MNU-induced retinal degeneration. B Biodistribution of PKH26-labeled MSCs in the eye after intravitreal injection for 6 h. NC negative control, injection of MSCs without staining. Scale bar = 2.5 mm. C Tracing of PKH26-labeled MSCs (red) in the retina tissue counterstained by Hoechst 33342 (blue) after intravitreal injection for 24 h. MSCT mesenchymal stem cell transplantation after MNU injection, INL inner nuclear layer, ONL outer nuclear layer. Scale bar = 50 mum. Representative hematoxylin and eosin (H&E) staining images of retinal tissues ( D ) and the corresponding quantitative analysis of ONL thickness ( E ). Ctrl control, no MNU treatment, GCL ganglion cell layer, ONH optic nerve head. Scale bars = 50 mum. * P < 0.05 by the Kruskal-Wallis test for area under curve (AUC). N = 3 per group. Representative scotopic electroretinography (ERG) waveforms ( F ) and the corresponding quantitative analyses of amplitude changes of a-wave ( G ) and b-wave ( H ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. Representative photopic ERG waveforms ( I ) and the corresponding quantitative analysis of b-wave amplitude changes ( J ). * P < 0.05 by the Kruskal-Wallis tests. N = 6 per group. K Representative immunofluorescen</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12428_fcimb-10-557610-g0003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 DENV infection causes dynamic changes in immune cell populations in the brain. (A) A gating immunostaining strategy was used for the indicated cell populations. The percentage of (B) CD19-positive cells, (C) CD3-positive cells, (D) CD11c and MHC II-positive cells, (E) NK1.1-positive cells, and (F) CD14-positive cells in the immune cell populations of the mouse brains on the indicated day post-infection were shown. Each point represents a mouse sample. Data show the means +- SD of based on at least three mice. * p < 0.05; *** p < 0.001. ns: not significant.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8375_thnov10p11376g001.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 Pre-depletion of microglia with PLX5622 reduces infiltrating cells and reactive oxygen species (ROS) production after SCI. ( A ) PLX5622 diet or vehicle chow were fed to animals three weeks before injury and remained for 2 days after injury. ( B ) Body weight was recorded both prior and after injury. All injured mice appeared significant loss of body weight. PLX had no effects on animal weight both prior and after injury. n = 30 mice/group before SCI and 12 (Sham/Veh), 12 (Sham/PLX), 18 (SCI/Veh), and 18 (SCI/PLX) mice after SCI. ( C ) Food intake was recorded both prior and after injury. In all injured mice, food consumption decreased significantly. PLX had no effects on food consumption both prior and after injury. n = 15 mice/group (Before injury) and 10 (Sham/Veh), 10 (Sham/PLX), 15 (SCI/Veh), and 15 (SCI/PLX) mice (After SCI). ( D ) Representative dot plots show the relative immune cell composition in the impact site of the spinal cord at two days post-injury. ( E ) The number of living CD45 int CD11b + Ly6C - microglia, CD45 hi CD11b + infiltrating myeloid cells, CD45 hi CD11b + Ly6C + Ly6G - monocytes, and CD45 hi CD11b + Ly6C + Ly6G + neutrophils are quantified. n = 6 (Sham/Veh), 6 (Sham/PLX), 7 (SCI/Veh), and 7 (SCI/PLX). ( F ) Representative histograms show the relative production of ROS in microglia, bulk infiltrating myeloid cells, monocytes, and neutrophils as measured by DHR123. ( G ) The mean fluorescence intensity (MFI) of dihydrorhodamine 123 (DHR123</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Inhibition of CCR2/5 signaling reduces CNS macrophage infiltration without altering activation marker expression of infiltrating macrophages. a Mice received a pair-fed diet (PF) or chronic alcohol (EtOH), and some alcohol-fed mice received 6 weeks of daily preventive subcutaneous CVC injection (EtOH + 6wk CVC) or 3 weeks of daily CVC treatment (EtOH + 3wk CVC). PF and EtOH mice received daily vehicle control injections. b Representative flow cytometry plots of peripheral macrophages (CD11b + CD45 hi ) in EtOH, EtOH + 6wk CVC and EtOH + 3wk CVC-treated mice. c Quantification of infiltrating brain macrophages (CD11b + CD45 hi ) in pair-fed, alcohol-fed, and treatment groups. d Expression of various activation markers were measured by flow cytometry in CD11b + CD45 hi infiltrating macrophages including CD86, CD68, MHC-II, CD163, and CD206. Data are mean +- SEM, n = 6-7 mice/group. * p < 0.05 by one-way ANOVA</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19137_12974_2020_1972_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Alcohol induces infiltration of peripheral macrophages into the CNS. a Alcohol-fed mice received 5% (v/v) alcohol in Lieber-DeCarli liquid diet ad libitum (EtOH) for 6 weeks while pair-fed animals received a calorie-matched liquid diet (PF). b mRNA expression of Ccl2 , Ccr2 , and Ccr5 was measured from the hippocampus of PF and EtOH mice. c Brain immune cells from wild-type mice fed chronic alcohol (EtOH) or a pair-fed (PF) control diet were isolated and quantified by flow cytometry gating for live, single cells. Microglia (CD11b + CD45 lo ) were differentiated from peripheral macrophages (CD11b + CD45 hi ) based on surface marker staining and infiltrating macrophages in pair- vs alcohol-fed mice. d Quantification of microglia (CD11b + CD45 lo ) and peripheral macrophages (CD11b + CD45 hi ) in PF and EtOH mice. Data are mean +- SEM, n = 4-7 mice/group. * p < 0.05 by Student's t test</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15099_41419_2020_3027_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Knockout of RAB6 promoted the self-renewal and proliferation of AEC2s. a The enriched AEC2 cell population was isolated by selection of the CD24 - SFTPC + subset from epithelial cell populations (EpCAM + CD31 - CD34 - CD45 - ) in lung tissues by FACS. b The localization and expression of RAB6 and SFTPC proteins in WT and RAB6 -/- AEC2 cells were detected by immunofluorescence (Green, RAB6; red, SFTPC; blue, DAPI) (Representative immunofluorescence images are shown, n = 3). c WT and RAB6 -/- AEC2 cells were exposed to PM2.5 (100 mug/ml) or saline for 48 h. The apoptosis of AEC2 cells was determined by FACS (Representative FACS images are shown, n = 3). d Statistical analysis of apoptosis rate. e The colony forming efficiency (CFE) of WT and RAB6 -/- AEC2 cells was examined by plate colony formation assay (Representative images are shown, n = 3). f Statistical analysis of CFE (represented by colony numbers). g Self-renewal (spherication ability) of WT and RAB6 -/- AEC2 cells exposed to PM2.5 or saline was detected by 3D culture (Representative images are shown, n = 3). h - j The relative RNA expression of SOX2 ( h ), OCT4 ( i ), and NANOG ( j ) was measured by qRT-PCR. ( n = 3; unpaired two-tailed t test. ** P < 0.01; *** P < 0.001. Bar graphs represent the mean +- SEM for d , f , h - j ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9817_jciinsight-5-136773-g165.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1 Lymphocytes make up the main immune population within digested GCT. Viable single tumor cell suspension and PBMCs from healthy donors were analyzed using polychromatic flow cytometry and progressive gating strategy. ( A ) Representative staining with CD3, CD4, CD8, CD25, CD45, and FOXP3 used to quantify helper (CD4 + ), cytotoxic (CD8 + ), and regulatory (Tregs) (CD4 + CD25 + FOXP3 + ) T cells in a GCT sample. ( B-D ) Representative staining with CD11b, HLA-DR, CD11c, Lineage, CD14, CD15, and CD33 used to identify the myeloid populations in a GCT sample. Tumor-associated macrophages (TAMs)/monocytes were separated from DC based on CD14 expression ( C ). Myeloid-derived suppressor cells (MDSC) were separated as eMDSC based on Lineage, HLA-DR, CD11b, and CD33 markers ( B ), whereas PMN-MDSC were characterized as CD15 + CD14 - CD11b + ( D ). Proportions of tumor-infiltrating immune cells in GCT were quantified as percentage of total cell suspension. ( E ) Percentages of CD4 + T cells, CD8 + T cells, and Tregs compared with total tumor cell suspension. ( F ) Comparison of PD1-expressing T cells in the GCT vs. PBMCs. ( G ) CD8 + T cells/Tregs ratio in GCT vs. PBMCs. ( H ) Percentage of TAMs/monocytes, DC, PMN-MDSC, and eMDSC of total tumor cell suspension. Mean +- SEM is shown. Each dot represents a patient ( n = 7) or healthy control PBMCs ( n = 3).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9903_jciinsight-5-137713-g026.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 Resolvin D1 limits inflammation and expedites its resolution following muscle injury. ( A ) C57BL/6 mice received bilateral intramuscular injection of the TA muscle with 50 muL of 1.2% BaCl 2 to induce myofiber injury. Mice were treated with RvD1 (100 ng) or vehicle (0.1% ethanol) via intraperitoneal (IP) injection approximately 5 minutes before muscle injury. TA cross sections were stained for PMNs (Ly6G) or monocytes/macrophages (CD68). Cell nuclei and the basal lamina were counterstained with DAPI and laminin antibody, respectively. Scale bars: 200 mum. ( B ) Whole-muscle mRNA expression of immune cell markers and inflammatory cytokines at 24 hours postinjury as determined by real-time quantitative reverse transcription PCR (RT-qPCR). Gene expression was normalized to Actb . ( C ) Mice were treated for 72 hours with daily IP injection of RvD1 (100 ng) or vehicle (0.1% ethanol) following muscle injury, and TA cross sections were stained for PMNs (Ly6G) or macrophages (CD68) at day 3 postinjury. Representative images show examples of regions of muscle not yet infiltrated by macrophages where lingering PMNs remained (top) and macrophage-rich regions largely devoid of PMNs (bottom). ( D ) Single cells isolated from pooled left and right TA muscles at day 3 postinjury were analyzed by flow cytometry for CD45-PE and Ly6G-FITC. Bars show the mean +- SEM of 5-10 mice per group with dots representing data from each mouse. P values were determined 2-tailed unpaired t tests.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g004.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 Population of CD11b + myeloid progenitor cells differentiate into SMA + stromal cells within tumors and in vitro. ( A ) Representative image of red fluorescent protein (RFP) + stromal cells in tumor from CCR2-RFP heterozygous SCID mouse. ( B ) RFP + SMA + double positive cells within tumor stroma. ( C ) CD11b + SMA + double positive cells within tumor stroma. ( D ) CD45 + CD11b + CD34+ myeloid progenitor cells in the mammary gland at 1.5 ( n = 5 empty vector (EV), 7 CCL2) and 2.5 weeks ( n = 5 EV, 7 CCL2) post-transplantation were quantified by flow cytometry. ( E ) CD45 + CD11b + CD34 + myeloid progenitor cells in the bone marrow at 1.5 weeks ( n = 6 EV, 7 CCL2) and 2.5 weeks ( n = 3 mice/group) post-transplantation were quantified by flow cytometry. ( F ) Representative brightfield image of colony formed by CD45 + CD11b + CD34 + myeloid progenitor cells isolated using fluorescence-activated cell sorting (FACS). ( G ) Colonies in culture co-stained with SMA and collagen I. Statistical differences determined by Mann-Whitney U test. Magnification bars = 50 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9852_cancers-12-02083-g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 Stromal CCL2 overexpression in mouse mammary glands leads to time-dependent changes in the developing tumor microenvironment. ( A ) Representative H&E images of oncogenic epithelial cell growth at 1.5 and 2.5 weeks post-transplantation. ( B ) Percent area of F4/80 + macrophages in developing tumors at 1.5 and 2.5 weeks post-transplantation ( n = 4 tumors/group; Student's t -test). ( C ) CD45 + CD11b + monocytes/macrophages in the mammary gland at 1.5 and 2.5 weeks post-transplantation were quantified by flow cytometry ( n = 5 EV, 7 CCL2, Mann-Whitney U test). ( D ) Percent area of SMA + cells in developing tumors at 1.5 and 2.5 weeks post-transplantation ( n = 4 tumors/group; Student's t -test). Magnification bars = 50 um.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9902_41467_2020_17557_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 DETC development requires Skint2 and Skint1 which form heteromers. a qPCR analysis for Skint1 and Skint2 message in adult mouse ear epidermis normalised to Ppia . Control , n = 8, Skint2 Delta/Delta , n = 8. Data are mean +- SD of a representative experiment of three independent experiments. b Analysis of E16.5 thymocytes in WT, Skint2 Delta/Delta and Skint1 Delta/Delta animals, gated on live gammadelta T cells (top panel). Thymic gammadelta cells (gate top row) were assessed for CD45RB, CD122, CD24 and CD62L and expression of the Vgamma5 TCR. Left panel: WT vs. Skint2 Delta/Delta , right panel: WT vs. Skint1 Delta/Delta . c Quantification of cell populations in quadrants Q1 to Q4 as indicated in ( b ), normalised to mean of wt = 1 for each quadrant, mean +- SD. WT n = 20; Skint2 Delta/Delta n = 5; Skint1 Delta/Delta n = 8 (two-tailed Man-Whitney analysis). d FACS analysis of ear epidermis in control ( Skint2 Delta/+ ) and Skint2 Delta/Delta mice. CD45 + , TCRgammadelta + cells (gate left panel) were stained for presence of Vgamma5Vdelta1 + DETC (stained by Vgamma5 and 17D1 antibody, right panel). e Microscopy images of adult mouse ear epidermal sheets in control and Skint2 Delta/Delta mice. Comparison of DETC stained for CD45 (top: blue) and Vgamma5 + (middle: green) gammadelta-TCR(GL3 + ) cells (bottom: red). Scale bar 50 um. f Quantification of DETC and Langerhans cell numbers from microscopy images, n = 15 for each genotype (data are from three independent experime</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15001_41418_2020_590_MOESM3_ESM.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Supplementary Figure S2</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15169_gr4_lrg.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 4 IL-31 in Wounds Was Mostly from Dermal cDC2s (A) Macrophages (CD45 + CD3 - CD11c - CD64 + CD11b + F4/80 + ), LCs (CD45 + CD3 - CD11c + CD326 + ), dermal cDC2s (CD45 + CD3 - CD11c + CD326 - CD64 - CD11b + MHC II + ), and dermal cDC1s (CD3 - CD11c + CD326 - CD64 - CD11b - MHC II + ) were sorted from fifth-day wounds, and Il31 expression was determined by real-time PCR. Data were from 2-3 independent experiments with 2 samples each time, and each sample was pooled from 4 wounds in 2 mice. Data were analyzed with one-way ANOVA for comparisons. Bars represent means +- SEM. **** p < 0.0001. (B) Il31 gene expression in dermal cDC2 from fifth-day wounds was compared with cDC2s from normal skin by real-time PCR. Data are from 3 independent experiments with 2 samples each time, and each sample was pooled from 4 wounds in 2 mice. Data were analyzed with Student's t test for comparisons. Bars represent means +- SEM. **** p < 0.0001. (C-E) Flow cytometer analysis showed that the frequency (C and D) and total numbers of dermal cDC2s (CD45 + CD11c + CD64 - CD11b + MHC II + CD326 - ) (E) were increased in fifth-day wound skin tissues compared with normal skin. In (D) and (E), each circle represents one mouse. Data were from 3 independent experiments (n = 5-6), and Student's t test was used. Bars represent means +- SEM. **** p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone marrow and culture for an equal number of passages, me v /me v and WT MSCs were harvested and analyzed for the indicated markers by immunofluorescence staining and flow cytometry. The experiments were repeated at least three times. Error bars represent +- SEM (n = 3), ns, not significant</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12872_41467_2020_16038_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 2 CK2 is required for bone formation during skeletal development. a Csnk2b mRNA levels in the hindlimbs (femur and tibia) of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. ( n = 4). b , c Alizarin red/alcian blue staining of skeletal preparations of E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos. Scale bar, 1 mm. Safranin O staining of humeri ( d ) and femurs ( e ) of P0 Csnk2b fl/fl and Csnk2b Prx1 pups. Scale bars, 250 mum (left) and 50 mum (right, enlarged one). f , g Csnk2b mRNA levels in SSCs (CD45 - Ter119 - Tie2 - alphaV-Int + Thy1 - 6C3 - CD105 - CD200 + ) isolated from E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryos ( f ). Frequency of SSCs within the population of total skeletal cells (CD45 - Ter119 - Tie2 - alphaV-Int + ) ( g ). f n = 4; g, n = 6 ( Csnk2b fl/fl ) or 5 ( Csnk2b Prx1 )). h - j SSCs (CD45 - Ter119 - Tie2 - alphaV-Int + Thy1 - 6C3 - CD105 - CD200 + ) isolated from E17.5 Csnk2b fl/fl and Csnk2b Prx1 embryonic limbs were transplanted beneath the kidney capsule. MicroCT analysis shows 3D-reconstruction ( h ) and quantification ( i ) of bone mass in the kidney capsule. BV bone volume. Histologic sections of kidney capsule were stained with H&E ( j , left) or Von Kossa ( j , right). The arrow highlights the ectopic bone. Scale bars, 200 mum ( h ); 100 mum ( j ). i n = 7 or 14. Data are representative of three ( a - e , h , j ) independent experiments or are pooled from two experiments ( f , g , i ). A two-tailed unpaired Student''s t test for comparing two groups</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 6 Ly6c Lo non-classical monocytes promote resolution of RRV-mediated periportal inflammation. ( a ) Dosage schedule illustrating regimen used to deplete Ly6c Hi classical monocytes (anti-Ccr2) and neutrophils (anti-Ly6g), and to inhibit Ly6c Lo non-classical monocytes (Cx3cr1 small molecular inhibitor, AZD8797) after inducing RRV-mediated liver injury in neonatal pups. ( b-d ) Depletion via anti-Ccr2 led to a 76% reduction of Ly6c Hi classical monocytes in the Cd45 + leukocyte compartment, which did not affect the proportion of Ly6c Lo non-classical monocytes (RRV n = 11, RRV anti-Ccr2 n = 10) and a 95% reduction of the absolute number of Ly6c Hi classical monocytes expected in a P7 liver. This led to a statistically significant increase in the ratio of Ly6c Lo : Ly6c Hi monocytes (p-value 0.026 (*)). ( e-g ) Depletion of neutrophils alone (p-value E : <0.0001 (****), p-value F : 0.048 (*)) led to an expansion of Ly6c Lo non-classical monocytes, (p-value F : 0.04 (*)), but did not change the ratio of Ly6c Lo : Ly6c Hi monocytes (( d ) RRV n = 14, RRV anti-Ly6g n = 7, ( e ) RRV n = 4, RRV anti-Ly6g n = 4). ( h-j ) Depleting both Ly6c Hi classical monocytes (p-value: 0.0207 (*)) and neutrophils (p-value: <0.0001 (****)) (Double Depletion, DD) led to further expansion of Ly6c Lo non-classical monocytes (p-value: <0.0001 (****)) (n = 4) and a significantly higher survival rate when compared to RRV alone (p-value 0.0002) or RRV plus single depletion (RRV n = 49, RRV Ly6c Hi</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12622_41598_2020_64158_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 Physiological abundance of Ly6c Lo non-classical monocytes compared to Ly6c Hi classical monocytes in the late gestation fetal liver. ( a ) Ly6c Lo monocytes, Ly6c Hi monocytes, and other leukocyte populations were identified by flow cytometry. ( b,c ) The overall proportion of Cd45 + leukocytes is relatively low in the late gestational fetal liver (E17.5, n = 11), then increases by day of birth (P0, n = 9), and plateaus (P3, n = 6; P7, n = 9; P10, n = 6; P14, n = 7), whereas the proportion in the spleen stays relatively stable (P0, n = 6; P3, n = 6; P7, n = 9; P10, n = 6; P14, n = 7. ( d,e ) Cd11b + monocytes were identified and are at their highest abundance of the Cd45 + leukocyte compartment in the late gestational liver (E17.5, n = 11). They then decrease at birth (P0, n = 6), rise again to a level that is between the two earlier time points (P3, n = 6; P7, n = 9), and then decrease to day of birth levels (P10, n = 6; P14, n = 4). In the spleen, Ly6c Lo non-classical monocytes remained low at birth and peaked at P7. (f-g) There is a physiological abundance of Ly6c Lo non-classical monocytes compared to Ly6c Hi classical monocytes at E17.5 in the liver that is not observed in the spleen (p-value % : <0.0001 (****), p-value # : 0.0007 (***)). Data represent mean +/- SEM.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12503_42003_2020_916_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 5 The synergistic anti-tumor effect of tankyrase and PD-1 inhibition is recapitulated by beta-catenin depletion in tumor cells and is dependent on IFNgamma and CD8 + T cells. a , B16-F10 Ctnnb1 KO tumor (s.c.) end volume reduction upon anti-PD-1 (-78%) and combined anti-PD-1/G007-LK treatment (-90%) in C57BL/6 N mice treated from day 11 through day 25. Control diet ( n = 9), G007-LK diet ( n = 9), anti-PD-1 ( n = 10), and anti-PD-1/G007-LK ( n = 10). Mann-Whitney rank sum tests are indicated by + ( P < 0.05) and ++ ( P < 0.01). For a - e Mean values are indicated by grey lines. b Tumor end volumes of B16-F10-challenged (s.c.) C57BL/6 Rag2 -/- mice treated for 12 days with control diet ( n = 11) compared to combined anti-PD-1/G007-LK treatment ( n = 10). n.s. not sig n ificant. c B16-F10 tumor (s.c.) end volume reduction upon anti-PD-1/G007-LK treatment in C57BL/6 N mice from day 10 through day 21. Control diet ( n = 11), anti-IgG1 isotype control ( n = 12), anti-IgG2 isotype control ( n = 10), anti-CD8alpha ( n = 10), anti-IFNgamma ( n = 9), anti-PD-1/G007-LK ( n = 10), anti-PD-1/G007-LK /anti-CD8alpha ( n = 9), and anti-PD-1/G007-LK /anti-IFNgamma ( n = 9). One-tailed t -tests are indicated by *( P <= 0.05) while one-tailed Mann-Whitney rank sum test is indicated by + ( P < 0.05). d Flow cytometry analysis of CD8 + and CD4 + T cells (shown as % of CD45 + T cells) from single-cell suspensions of comparable-sized tumors collected from B16-F10-challenged (s.c.) C57BL/6 N m</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12871_12974_2020_1816_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Fig. 5 Boc2-treatment reduces plaque load and phagocytosis rate of Abeta in APP/PS1 double-transgenic mice. Coronal brain sections of 29-week-old APP/PS1 double-transgenic mice with or without Boc2 treatment stained with anti-Beta-Amyloid 1-42 were used for the determination of plaque load. a Analysis of the total hippocampal Abeta plaque load (number/mm 2 ). b The average number of plaques/mm 2 grouped in four different size categories (< 125 mum 2 , 125-250 mum 2 , 250-500 mum 2 , and > 500 mum 2 ). Plaque numbers were analyzed in anti-Beta-Amyloid 1-42 processed sections. c Abeta phagocytosis rate (in %), analyzed by flow cytometry of microglia isolated from APP/PS1 double-transgenic mice with or without Boc2 treatment 3 h after intraperitoneal injection of methoxy-XO4. d Representative images of hippocampal plaques analysis demonstrating the evaluation process with ImageJ. Scale bar: 250 mum. e Average microglial cell area (mum 2 ) around the Abeta plaques, visualized by anti-IBA-1 stains in the hippocampus of APP/PS1 double-transgenic mice with or without Boc2 or fMLF treatment. f Representative image of a plaque stained with anti-IBA-1 (red) and anti-beta-Amyloid 1-42 (blue). Statistical significances were determined using Mann-Whitney U test ( a ), Kruskal-Wallis followed Dunn test ( b ), two-way ANOVA with turkey test ( d ), or t-test ( f ). Data represent mean + SEM; n >= 7; * p < 0.05, ** p < 0.01, *** p < 0.001 as indicated</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g002.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 2 Combination of GW9662 and alphaPD-L1 elicits more tumor-infiltrating T cells and anti-tumor cytokines in CD8 + TILs versus single agents. (A) Percentage of CD3 + T lymphocytes of live CD45 + cells from tumors isolated 13 days post tumor injection in female mice following various treatments as indicated. (B) Percentage of CD8 + T cells percentage (of CD45 + CD3 + cells) in alphaPD-L1 and GW9662 combination treatment group. (C) Percentage of CD4 + T cells (of CD45 + CD3 + cells). (D) Representative flow cytometry of the IFN-gamma and TNF-alpha staining in CD45 + CD3 + CD8 + TILs. (E) IFN-gamma + , (f) TNF-alpha + and (G) dual positive IFN-gamma + TNF-alpha + percentage gated on CD45 + CD3 + CD8 + T cells. (H) Mean fluorescent intensity (MFI) of IFN-gamma, an indicator of cytokine production per cell in various treatment groups. N=4 mice per group. VEH: DMSO+alphaIgG/. alphaPD-L1: DMSO+alphaPD-L1. GW: GW9662+alphaIgG. alphaPD-L1+GW: alphaPD-L1+GW9662. Data represent mean +- SD. P values as indicated.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7910_ijbsv16p1526g003.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 3 Male hosts are refractory to the GW9662 + alphaPD-L1 combination treatment in a castration-independent manner. (A) B16 tumor growth curves in normal male mice (n=5 per group). (B-D) B16 tumor growth in age-matched female (n=10 per group) (b), sham surgery-treated male (n=9 for VEH, n=8 for alphaPD-L1+GW) (c) and castrated male mice (n=9 for VEH, n=10 for alphaPD-L1+GW) (d). VEH: DMSO+ alphaIgG. alphaPD-L1: DMSO+alphaPD-L1. GW: GW9662+alphaIgG. alphaPD-L1+GW: alphaPD-L1+GW9662. (E-G) TIL analysis for B16 tumors in age-matched female, sham-treated male and castrated male mice. Percentage of (e) CD3 + (of CD45 + ), (f) CD8 + (of CD45 + CD3 + ), (g) T cell stem cell marker TCF-1 + (of CD45 + CD3 + CD8 + ). N=4 mice per group for panel e-g. (F) Female. Sham M: sham surgery-treated male. Castrated M: castrated male. Data represent mean +- SD. P values as indicated.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time=20240507?time=20240507" alt="CD45 Antibody in Flow Cytometry (Flow)" title="CD45 Antibody (12-0451-82) in Flow"> <figcaption itemprop="caption">Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks of culture in osteogenic induction medium, the cells were stained with alizarin red. Mineralized nodules are shown. (I) Following 3 weeks of culture in adipogenic induction medium, the cells were stained with Oil Red O. Lipid globules are shown (black arrow). hPDLSCs, human periodontal ligament stem cells; PE, phycoerythrin.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3583_10.1177_0271678X17694185-fig1.jpg?time=20240507?time=20240507" alt="CD45 Antibody" title="CD45 Antibody (12-0451-82)"> <figcaption itemprop="caption">Figure 1. PLX3397 treatment eliminated microglia and exacerbated stroke severity in MCAO mice. Wild type C57BL/6 mice were fed PLX3397 or control chow diet for 21 days prior to sham or MCAO surgeries. After surgeries, these mice continued to receive PLX3397 or control diet until they were sacrificed. At day 1 or day 3 after 60 min MCAO and reperfusion, mice were subjected to neurological assessment, MRI, flow cytometry, and pathology staining. (a) Schematic showing the experimental design. (b) Representative flow cytometry plots show the gating strategy of CD11b + CD45 int microglial cell population. Bar graphs summarize the results from sham or MCAO mice receiving the indicated treatment at day 1 and day 3 after MCAO reperfusion. (c) Bar graphs illustrate the indicated neurological assessments of sham and MCAO mice receiving PLX3397 or control diet at day 1 or day 3 after reperfusion. (d) Representative MRI images show infarct area (outlined in red) in MCAO mice receiving PLX3397 or control diet after MCAO reperfusion. Bar graphs show the infarct volume of MCAO mice receiving PLX3397 or control diet at indicated time points. n = 15 mice per group. Error bars represent SD; * P < 0.05; ** P < 0.01. {TM}</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>12-0451-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 4 publications</span> <span class="mobile-view">4 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (PFA fixed) (IHC (PFA))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCPFA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 3 publications</span> <span class="mobile-view">3 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl">0.125 µg/test</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 301 publications</span> <span class="mobile-view">301 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Affinity Purification (AP)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#AP-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 2 publications</span> <span class="mobile-view">2 publications</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Human,</span> <span>Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2b, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Recommended Isotype Control</h2> </div> <div class="product-item left-flex-cls"> <a href="//www.thermofisher.com/antibody/product/12-4031-82"> Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™</a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 30-F11 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('PE ') && '/us/en/home/life-science/cell-analysis/fluorophores/r-phycoerythrin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() != ''" href="/us/en/home/life-science/cell-analysis/fluorophores/r-phycoerythrin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">PE </a> <span ng-if="($ctrl.checkConjugate('PE ') && '/us/en/home/life-science/cell-analysis/fluorophores/r-phycoerythrin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() == '')" class="conjugate-value">PE </span> <span ng-if="!$ctrl.checkConjugate('PE ')" class="conjugate-value">PE </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/14-0451-82"> Unconjugated <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/53-0451-82"> Alexa Fluor 488 <span class="conjugate-indicator" style="background-color:#36FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/58-0451-82"> Alexa Fluor 532 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/505-0451-82"> Alexa Fluor 561 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/606-0451-82"> Alexa Fluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/56-0451-82"> Alexa Fluor 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/17-0451-82"> APC <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/47-0451-82"> APC-eFluor 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/13-0451-82"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/363-0451-82"> Brilliant UV 395 <span class="conjugate-indicator" style="background-color:#8000A1"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/364-0451-82"> Brilliant UV 496 <span class="conjugate-indicator" style="background-color:#00FFFF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/365-0451-82"> Brilliant UV 563 <span class="conjugate-indicator" style="background-color:#C3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/366-0451-82"> Brilliant UV 615 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/376-0451-82"> Brilliant UV 661 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/367-0451-82"> Brilliant UV 737 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/368-0451-82"> Brilliant UV 805 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/404-0451-82"> Brilliant Violet 421 <span class="conjugate-indicator" style="background-color:#5400FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/414-0451-82"> Brilliant Violet 480 <span class="conjugate-indicator" style="background-color:#00C0FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/406-0451-82"> Brilliant Violet 605 <span class="conjugate-indicator" style="background-color:#FFAD00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/416-0451-82"> Brilliant Violet 650 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/407-0451-82"> Brilliant Violet 711 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/417-0451-82"> Brilliant Violet 786 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/48-0451-82"> eFluor 450 <span class="conjugate-indicator" style="background-color:#0028FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/69-0451-82"> eFluor 506 <span class="conjugate-indicator" style="background-color:#00FF54"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/11-0451-82"> FITC <span class="conjugate-indicator" style="background-color:#1FFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/16-0451-85"> Functional Grade <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B01-A"> NovaFluor Blue 510 <span class="conjugate-indicator" style="background-color:#00FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B03-A"> NovaFluor Blue 555 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B04-A"> NovaFluor Blue 585 <span class="conjugate-indicator" style="background-color:#FFEF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B05-A"> NovaFluor Blue 610-30S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B06-A"> NovaFluor Blue 610-70S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B08-A"> NovaFluor Blue 660-120S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02B07-A"> NovaFluor Blue 660-40S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02R03-A"> NovaFluor Red 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02R04-A"> NovaFluor Red 710 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02Y03-A"> NovaFluor Yellow 610 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02Y04-A"> NovaFluor Yellow 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02Y05-A"> NovaFluor Yellow 690 <span class="conjugate-indicator" style="background-color:#970000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02Y06-A"> NovaFluor Yellow 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M005T02Y07-A"> NovaFluor Yellow 730 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/15-0451-82"> PE-Cyanine5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/35-0451-82"> PE-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/25-0451-82"> PE-Cyanine7 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/61-0451-82"> PE-eFluor 610 <span class="conjugate-indicator" style="background-color:#FF9B00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/45-0451-82"> PerCP-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/62-0451-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-0451-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-0451-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-0451-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-0451-82"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Excitation/Emission Max</h2> </div> <div class="product-item left-flex-cls"> <span>565/576 nm</span> <a target="_blank" class="spectra-view" href="/order/fluorescence-spectraviewer?SID=srch-svtool&UID=801ph75"> <span class="view-spectra"> View spectra</span> <span class="spectra-view-icon "><img src="/order/genome-database/assets/img/spectra.png" alt="spectra"/></span> </a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.2 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C, store in dark, DO NOT FREEZE! </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_465668</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The 30-F11 monoclonal antibody reacts with all isoforms of mouse CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.<br /><br />Applications Reported: The 30-F11 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: This 30-F11 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> <div class="product-detail-video"> <div tf-video-player-new video-id="6206990159001" player-width="368" player-height="210"></div> <div class="panel-builder"> <h4 class="product-info-para-heading"> How to use the Panel Builder </h4> <p>Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.</p> </div> </div> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'12-0451-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-3" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="313" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"IHC","citations":[{"title":"A patient derived xenograft model of cervical cancer and cervical dysplasia.","summary":"12-0451 was used in Immunohistochemistry to develop a patient derived xenograft model of cervical cancer and cervical dysplasia using the subrenal capsule.","authors":"Larmour LI,Cousins FL,Teague JA,Deane JA,Jobling TW,Gargett CE","literatureId":"30365542","journal":"PloS one","volume":"13","publishedDate":"Mar 29, 2019, 4:00:00 AM","url":"http://dx.doi.org/10.1371/journal.pone.0206539","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"PLoS One","sortOrder":179,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:100"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~1:100":"1:100"}},{"title":"The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.","summary":"12-0451 was used in Immunohistochemistry-immunofluorescence to observe the role played by the Hippo pathway in suppressing anti-tumour immunity.","authors":"Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL","literatureId":"27912060","journal":"Cell","volume":"167","pageNumber":"1525","publishedDate":"Dec 1, 2016, 5:00:00 AM","url":"http://dx.doi.org/10.1016/j.cell.2016.11.005","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Cell","sortOrder":216,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"Not Cited"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~Not Cited":""}},{"title":"Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles.","summary":"12-0451-82 was used in Immunohistochemistry to report incorporation of sunitinib, a tyrosine kinase inhibitor that blocks VEGF receptors, into a non-inflammatory biodegradable polymer to generate sunitinib microparticles specially formulated to self-aggregate into a depot.","authors":"Tsujinaka H,Fu J,Shen J,Yu Y,Hafiz Z,Kays J,McKenzie D,Cardona D,Culp D,Peterson W,Gilger BC,Crean CS,Zhang JZ,Kanan Y,Yu W,Cleland JL,Yang M,Hanes J,Campochiaro PA","literatureId":"32019921","journal":"Nature communications","volume":"11","publishedDate":"Feb 4, 2020, 5:00:00 AM","url":"http://dx.doi.org/10.1038/s41467-020-14340-x","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Nat Commun","sortOrder":120,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"Not Cited"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~Not Cited":""}}],"citationsCount":4,"speciesList":["Mouse"],"journals":["PLoS One","Nat Commun","Oncogene","Cell"],"speciesMap":{"Mouse":4},"journalsMap":{"PLoS One":1,"Nat Commun":1,"Oncogene":1,"Cell":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (PFA)","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["J Exp Med"],"speciesMap":{"Mouse":1},"journalsMap":{"J Exp Med":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (F)","citations":[],"citationsCount":3,"speciesList":["Mouse"],"journals":["Nat Commun","Sci Rep","Am J Physiol Lung Cell Mol Physiol"],"speciesMap":{"Mouse":3},"journalsMap":{"Nat Commun":1,"Sci Rep":1,"Am J Physiol Lung Cell Mol Physiol":1},"sortedMap":{}},{"applicationAbbreviation":"ICC/IF","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Proc Natl Acad Sci U S A"],"speciesMap":{"Mouse":1},"journalsMap":{"Proc Natl Acad Sci U S A":1},"sortedMap":{}},{"applicationAbbreviation":"Flow","citations":[],"citationsCount":301,"speciesList":["Human","Mouse"],"journals":["NPJ Vaccines","Brain","Mol Med Rep","Cell Mol Biol Lett","Nat Commun","Methods Mol Biol","Int J Med Sci","Invest Ophthalmol Vis Sci","Front Cardiovasc Med","Blood","J Cell Mol Med","Stem Cells","Nat Neurosci","Toxicology","Nat Med","Arterioscler Thromb Vasc Biol","J Autoimmun","Development","Nat Cell Biol","Am J Pathol","J Am Heart Assoc","Stem Cell Res","eNeuro","PLoS One","J Cell Biochem","Dev Cell","EMBO Rep","J Neurosci Methods","Skelet Muscle","J Am Soc Nephrol","J Extracell Vesicles","J Neuroinflammation","Int J Biol Sci","Nat Struct Mol Biol","J Cereb Blood Flow Metab","Bioact Mater","Elife","J Immunol","Mol Cell","NPJ Regen Med","Mol Metab","Muscle Nerve","Nat Biotechnol","Hum Mol Genet","Am J Physiol Lung Cell Mol Physiol","Anticancer Drugs","J Neurosci","J Leukoc Biol","JCI Insight","Oncoimmunology","Aging Cell","J Invest Dermatol","Nature","J Nanobiotechnology","Stem Cell Reports","Front Cell Infect Microbiol","Cardiovasc Diabetol","Cell Transplant","Cancer Cell","Br J Pharmacol","Cell Physiol Biochem","Immun Inflamm Dis","Adv Sci (Weinh)","J Clin Invest","Exp Hematol","Cell Stem Cell","J Cell Physiol","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Commun Biol","J Bone Miner Res","Breast Cancer Res","Sci Adv","J Cell Commun Signal","Immunol Cell Biol","Front Cell Dev Biol","Biochemistry","Mol Cell Biol","Immunity","Front Mol Neurosci","Ann Surg","Neurosci Lett","Open Life Sci","Cell Biosci","Cell","Cancer Res","Kidney360","Front Nutr","Cancers (Basel)","Cytokine","Acta Pharm Sin B","NPJ Aging Mech Dis","STAR Protoc","Cell Host Microbe","Stem Cell Res Ther","Ther Adv Chronic Dis","Chin Med J (Engl)","Sci Rep","Bio Protoc","Cell Death Differ","Adipocyte","EMBO Mol Med","Cardiovasc Res","EMBO J","Cell Mol Immunol","J Allergy Clin Immunol","Int J Mol Sci","Nat Immunol","BMC Biol","J Exp Med","Transplantation","Cell Rep","Exp Ther Med","Genes Dev","Cell Death Dis","Cell Mol Life Sci","J Virol","J Neuroimmunol","J Immunother Cancer","J Biomed Sci","Nutrients","Am J Physiol Renal Physiol","Front Immunol","Front Pharmacol","Theranostics","Cells","Pain Res Manag","Basic Res Cardiol","Cell Mol Gastroenterol Hepatol","Life Sci Alliance","PLoS Pathog","J Biol Chem","Glia","Prostate","Cytometry A"],"speciesMap":{"Human":8,"Mouse":130},"journalsMap":{"NPJ Vaccines":1,"Brain":1,"Mol Med Rep":4,"Cell Mol Biol Lett":2,"Nat Commun":27,"Methods Mol Biol":1,"Int J Med Sci":1,"Invest Ophthalmol Vis Sci":1,"Front Cardiovasc Med":1,"Blood":1,"J Cell Mol Med":1,"Stem Cells":3,"Nat Neurosci":2,"Toxicology":1,"Nat Med":1,"Arterioscler Thromb Vasc Biol":1,"J Autoimmun":1,"Development":3,"Nat Cell Biol":4,"Am J Pathol":1,"J Am Heart Assoc":1,"Stem Cell Res":1,"eNeuro":1,"PLoS One":9,"J Cell Biochem":2,"Dev Cell":1,"EMBO Rep":2,"J Neurosci Methods":1,"Skelet Muscle":1,"J Am Soc Nephrol":2,"J Extracell Vesicles":1,"J Neuroinflammation":6,"Int J Biol Sci":1,"Nat Struct Mol Biol":1,"J Cereb Blood Flow Metab":2,"Bioact Mater":1,"Elife":9,"J Immunol":4,"Mol Cell":1,"NPJ Regen Med":1,"Mol Metab":1,"Muscle Nerve":1,"Nat Biotechnol":1,"Hum Mol Genet":1,"Am J Physiol Lung Cell Mol Physiol":1,"Anticancer Drugs":1,"J Neurosci":1,"J Leukoc Biol":1,"JCI Insight":11,"Oncoimmunology":2,"Aging Cell":1,"J Invest Dermatol":1,"Nature":6,"J Nanobiotechnology":3,"Stem Cell Reports":2,"Front Cell Infect Microbiol":1,"Cardiovasc Diabetol":1,"Cell Transplant":3,"Cancer Cell":2,"Br J Pharmacol":1,"Cell Physiol Biochem":1,"Immun Inflamm Dis":1,"Adv Sci (Weinh)":1,"J Clin Invest":6,"Exp Hematol":1,"Cell Stem Cell":4,"J Cell Physiol":2,"Acta Neuropathol Commun":1,"Proc Natl Acad Sci U S A":3,"Commun Biol":1,"J Bone Miner Res":1,"Breast Cancer Res":1,"Sci Adv":1,"J Cell Commun Signal":1,"Immunol Cell Biol":2,"Front Cell Dev Biol":1,"Biochemistry":1,"Mol Cell Biol":1,"Immunity":6,"Front Mol Neurosci":1,"Ann Surg":1,"Neurosci Lett":1,"Open Life Sci":1,"Cell Biosci":1,"Cell":5,"Cancer Res":3,"Kidney360":1,"Front Nutr":1,"Cancers (Basel)":3,"Cytokine":1,"Acta Pharm Sin B":2,"NPJ Aging Mech Dis":1,"STAR Protoc":2,"Cell Host Microbe":1,"Stem Cell Res Ther":1,"Ther Adv Chronic Dis":1,"Chin Med J (Engl)":1,"Sci Rep":9,"Bio Protoc":1,"Cell Death Differ":3,"Adipocyte":2,"EMBO Mol Med":3,"Cardiovasc Res":2,"EMBO J":1,"Cell Mol Immunol":1,"J Allergy Clin Immunol":1,"Int J Mol Sci":5,"Nat Immunol":1,"BMC Biol":1,"J Exp Med":2,"Transplantation":1,"Cell Rep":7,"Exp Ther Med":2,"Genes Dev":1,"Cell Death Dis":4,"Cell Mol Life Sci":1,"J Virol":1,"J Neuroimmunol":1,"J Immunother Cancer":3,"J Biomed Sci":1,"Nutrients":1,"Am J Physiol Renal Physiol":1,"Front Immunol":9,"Front Pharmacol":1,"Theranostics":1,"Cells":1,"Pain Res Manag":1,"Basic Res Cardiol":1,"Cell Mol Gastroenterol Hepatol":2,"Life Sci Alliance":1,"PLoS Pathog":4,"J Biol Chem":4,"Glia":6,"Prostate":1,"Cytometry A":1},"sortedMap":{}},{"applicationAbbreviation":"AP","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Cell Rep"],"speciesMap":{"Mouse":1},"journalsMap":{"Cell Rep":1},"sortedMap":{}},{"applicationAbbreviation":"Misc","citations":[],"citationsCount":2,"speciesList":["Mouse"],"journals":["Stem Cell Res","Nat Med"],"speciesMap":{"Mouse":2},"journalsMap":{"Stem Cell Res":1,"Nat Med":1},"sortedMap":{}}]}'></reference-section> </div> <noscript> <div itemscope itemtype="https://schema.org/ScholarlyArticle"> <h2>Product References</h2> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37552209"> <div itemprop="name">Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 11 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37848990"> <div itemprop="name">Exosomes from umbilical cord-derived mesenchymal stem cells combined with gelatin methacryloyl inhibit vein graft restenosis by enhancing endothelial functions.</div> </a> <div itemprop="about">Journal of nanobiotechnology</div> <div itemprop="author">Deng Y,Li Y,Chu Z,Dai C,Ge J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 18 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36869026"> <div itemprop="name">Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cheong LY,Wang B,Wang Q,Jin L,Kwok KHM,Wu X,Shu L,Lin H,Chung SK,Cheng KKY,Hoo RLC,Xu A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 03 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36988250"> <div itemprop="name">NCR negative group 3 innate lymphoid cell (NCR<sup>-</sup> ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.</div> </a> <div itemprop="about">Immunity, inflammation and disease</div> <div itemprop="author">Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to investigate the role of Natural Cytotoxicity Receptor negative innate lymphoid cells (NCR- ILC3) in the pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoking.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36928191"> <div itemprop="name">Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Larson-Casey JL,Liu S,Pyles JM,Lapi SE,Saleem K,Antony VB,Gonzalez ML,Crossman DK,Carter AB</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to suggest that impaired activation of PPAR? in monocyte-derived macrophages exacerbates lung injury and the severity of LRTIs.</div> <div itemprodp="datePublished">Mon May 08 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36520372"> <div itemprop="name">Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids.</div> </a> <div itemprop="about">EMBO reports</div> <div itemprop="author">Caratti G,Desgeorges T,Juban G,Stifel U,Fessard A,Koenen M,Caratti B,Théret M,Skurk C,Chazaud B,Tuckermann JP,Mounier R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 06 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36901755"> <div itemprop="name">Topical Diacerein Decreases Skin and Splenic CD11c<sup>+</sup> Dendritic Cells in Psoriasis.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Brunner SM,Ramspacher A,Rieser C,Leitner J,Heil H,Ablinger M,Tevini J,Wimmer M,Koller A,Piñón Hofbauer J,Felder TK,Bauer JW,Kofler B,Lang R,Wally V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 21 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37705115"> <div itemprop="name">Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle.</div> </a> <div itemprop="about">Skeletal muscle</div> <div itemprop="author">Oprescu SN,Baumann N,Chen X,Sun Q,Zhao Y,Yue F,Wang H,Kuang S</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to identify Sox11 as a novel myogenic differentiation marker with reduced expression in quiescent and aged MuSCs, but the specific function of Sox11 in myogenesis remains to be elucidated.</div> <div itemprodp="datePublished">Wed Sep 13 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36731891"> <div itemprop="name">BRCA1 deficiency in mature CD8<sup>+</sup> T lymphocytes impairs antitumor immunity.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36828819"> <div itemprop="name">CD11c<sup>+</sup> microglia promote white matter repair after ischemic stroke.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 24 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36592421"> <div itemprop="name">Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36873185"> <div itemprop="name">Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in <i>NPM1</i>-mutated acute myeloid leukemia.</div> </a> <div itemprop="about">Acta pharmaceutica Sinica. B</div> <div itemprop="author">Feng Y,Han Y,Hu A,Qu Y,Hu Y,Wu H,Wang X,He L</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to suggest a novel treatment strategy and lead compound for acute myeloid leukemia patients, especially those with NPM1 mutations.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35768512"> <div itemprop="name">Enteric viruses replicate in salivary glands and infect through saliva.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Ghosh S,Kumar M,Santiana M,Mishra A,Zhang M,Labayo H,Chibly AM,Nakamura H,Tanaka T,Henderson W,Lewis E,Voss O,Su Y,Belkaid Y,Chiorini JA,Hoffman MP,Altan-Bonnet N</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to uncover a new transmission route for enteric viruses with implications for therapeutics, diagnostics and importantly sanitation measures to prevent spread through saliva.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35768512"> <div itemprop="name">Enteric viruses replicate in salivary glands and infect through saliva.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Ghosh S,Kumar M,Santiana M,Mishra A,Zhang M,Labayo H,Chibly AM,Nakamura H,Tanaka T,Henderson W,Lewis E,Voss O,Su Y,Belkaid Y,Chiorini JA,Hoffman MP,Altan-Bonnet N</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to uncover a new transmission route for enteric viruses with implications for therapeutics, diagnostics and importantly sanitation measures to prevent spread through saliva.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35389887"> <div itemprop="name">The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Liang J,Huang G,Liu X,Taghavifar F,Liu N,Wang Y,Deng N,Yao C,Xie T,Kulur V,Dai K,Burman A,Rowan SC,Weigt SS,Belperio J,Stripp B,Parks WC,Jiang D,Noble PW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35300585"> <div itemprop="name">Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.</div> </a> <div itemprop="about">Cellular & molecular biology letters</div> <div itemprop="author">Gao T,Huang F,Wang W,Xie Y,Wang B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35192678"> <div itemprop="name">BEX1 is a critical determinant of viral myocarditis.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Martens CR,Dorn LE,Kenney AD,Bansal SS,Yount JS,Accornero F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36066975"> <div itemprop="name">GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">de Souza CO,Paschoal VA,Sun X,Vishvanath L,Zhang Q,Shao M,Onodera T,Chen S,Joffin N,Bueno LM,Gupta RK,Oh DY</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36040807"> <div itemprop="name">Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Howard ZM,Gomatam CK,Rabolli CP,Lowe J,Piepho AB,Bansal SS,Accornero F,Rafael-Fortney JA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 10 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36703732"> <div itemprop="name">Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.</div> </a> <div itemprop="about">Frontiers in pharmacology</div> <div itemprop="author">Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 02 00:00:00 EST 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35943203"> <div itemprop="name">Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Garrido-Gil P,Pedrosa MA,Garcia-Garrote M,Pequeño-Valtierra A,Rodríguez-Castro J,García-Souto D,Rodríguez-Pérez AI,Labandeira-Garcia JL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35897814"> <div itemprop="name">Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 26 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35027468"> <div itemprop="name">Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF.</div> </a> <div itemprop="about">Life science alliance</div> <div itemprop="author">Dichtl S,Sanin DE,Koss CK,Willenborg S,Petzold A,Tanzer MC,Dahl A,Kabat AM,Lindenthal L,Zeitler L,Satzinger S,Strasser A,Mann M,Roers A,Eming SA,El Kasmi KC,Pearce EJ,Murray PJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35393953"> <div itemprop="name">Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Linnerbauer M,Lößlein L,Vandrey O,Tsaktanis T,Beer A,Naumann UJ,Panier F,Beyer T,Nirschl L,Kuramatsu JB,Winkler J,Quintana FJ,Rothhammer V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35263568"> <div itemprop="name">A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.</div> <div itemprodp="datePublished">Tue Mar 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35020422"> <div itemprop="name">Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Kumar B,Adebayo AK,Prasad M,Capitano ML,Wang R,Bhat-Nakshatri P,Anjanappa M,Simpson E,Chen D,Liu Y,Schilder JM,Colter AB,Maguire C,Temm CJ,Sandusky G,Doud EH,Wijeratne AB,Mosley AL,Broxmeyer HE,Nakshatri H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34914635"> <div itemprop="name">The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Bechara R,Amatya N,Majumder S,Zhou C,Li Y,Liu Q,McGeachy MJ,Gaffen SL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36595920"> <div itemprop="name">Labeling and analyzing lipid droplets in mouse muscle stem cells.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Chen J,Yue F,Kuang S</div> <div itemprop="description">12-0451-82 was used in flow cytometry to describe a protocol which includes steps for BODIPY/LipidSpot610 staining of freshly isolated MuSCs, flow cytometry cultured myoblasts, and single myofibers to label lipid droplets and subsequent analysis and quantification of fluorescence signals.</div> <div itemprodp="datePublished">Fri Dec 16 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35236741"> <div itemprop="name">Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Hu J,He J,Wang Y,Zhao Y,Fang K,Dong Y,Chen Y,Zhang Y,Zhang C,Wang H,Tan J,Wang J,Zi R,Liu C,Liang H,Guo Y,Ou J</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to provide a promising strategy for sensitizing poorly immunogenic solid tumors to immunotherapy in the clinic.</div> <div itemprodp="datePublished">Tue Mar 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36242070"> <div itemprop="name">Tannin coordinated nanozyme composite-based hybrid hydrogel eye drops for prophylactic treatment of multidrug-resistant Pseudomonas aeruginosa keratitis.</div> </a> <div itemprop="about">Journal of nanobiotechnology</div> <div itemprop="author">Wang H,Song F,Feng J,Qi X,Ma L,Xie L,Shi W,Zhou Q</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to reveal the potential of tannin-coordinated nanozyme composite-based hybrid hydrogel eye drops for treating infectious diseases.</div> <div itemprodp="datePublished">Fri Oct 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35578835"> <div itemprop="name">Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Miyao T,Miyauchi M,Kelly ST,Terooatea TW,Ishikawa T,Oh E,Hirai S,Horie K,Takakura Y,Ohki H,Hayama M,Maruyama Y,Seki T,Ishii H,Yabukami H,Yoshida M,Inoue A,Sakaue-Sawano A,Miyawaki A,Muratani M,Minoda A,Akiyama N,Akiyama T</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to provide evidence for the existence of transit-amplifying Aire+mTEC precursors during the Aire+mTEC differentiation process of the postnatal thymus.</div> <div itemprodp="datePublished">Tue May 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33388094"> <div itemprop="name">Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33388094"> <div itemprop="name">Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 10 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34180951"> <div itemprop="name">Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33996416"> <div itemprop="name">Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model.</div> </a> <div itemprop="about">Acta pharmaceutica Sinica. B</div> <div itemprop="author">Lin Z,Xi L,Chen S,Tao J,Wang Y,Chen X,Li P,Wang Z,Zheng Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33555074"> <div itemprop="name">Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33929610"> <div itemprop="name">Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.</div> </a> <div itemprop="about">Basic research in cardiology</div> <div itemprop="author">Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33082517"> <div itemprop="name">Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to discover that intravitreal MSCT counteracted photoreceptor apoptosis and alleviate retinal morphological and functional degeneration in a mouse model of photoreceptor loss induced by N-methyl-N-nitrosourea (MNU).</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33082517"> <div itemprop="name">Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to discover that intravitreal MSCT counteracted photoreceptor apoptosis and alleviate retinal morphological and functional degeneration in a mouse model of photoreceptor loss induced by N-methyl-N-nitrosourea (MNU).</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32694652"> <div itemprop="name">Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show by microCT that mice with p53 deletion systemically or specifically in mesenchymal cells possess significantly higher bone density than their respective littermate controls.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32694652"> <div itemprop="name">Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show by microCT that mice with p53 deletion systemically or specifically in mesenchymal cells possess significantly higher bone density than their respective littermate controls.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34327802"> <div itemprop="name">Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis.</div> </a> <div itemprop="about">Aging cell</div> <div itemprop="author">Funk KE,Arutyunov AD,Desai P,White JP,Soung AL,Rosen SF,Diamond MS,Klein RS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32157317"> <div itemprop="name">Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.</div> </a> <div itemprop="about">Cellular and molecular life sciences : CMLS</div> <div itemprop="author">Caputo T,Tran VDT,Bararpour N,Winkler C,Aguileta G,Trang KB,Giordano Attianese GMP,Wilson A,Thomas A,Pagni M,Guex N,Desvergne B,Gilardi F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34121311"> <div itemprop="name">RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.</div> </a> <div itemprop="about">EMBO reports</div> <div itemprop="author">Hu Y,Li X,Zhi X,Cong W,Huang B,Chen H,Wang Y,Li Y,Wang L,Fang C,Guo J,Liu Y,Cui J,Cao L,Weng W,Zhou Q,Wang S,Chen X,Su J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34174813"> <div itemprop="name">Macrophage polarization by MSC-derived CXCL12 determines tumor growth.</div> </a> <div itemprop="about">Cellular & molecular biology letters</div> <div itemprop="author">Babazadeh S,Nassiri SM,Siavashi V,Sahlabadi M,Hajinasrollah M,Zamani-Ahmadmahmudi M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33296111"> <div itemprop="name">The effects of postmortem delay on mouse and human microglia gene expression.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33068332"> <div itemprop="name">Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Zhang X,Heng Y,Kooistra SM,van Weering HRJ,Brummer ML,Gerrits E,Wesseling EM,Brouwer N,Nijboer TW,Dubbelaar ML,Boddeke EWGM,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33651379"> <div itemprop="name">Intercellular Interactions of an Adipogenic CXCL12-Expressing Stromal Cell Subset in Murine Bone Marrow.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Matsushita Y,Chu AKY,Ono W,Welch JD,Ono N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34095141"> <div itemprop="name">Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Ying L,Zhang M,Ma X,Si Y,Li X,Su J,Yin J,Bao Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34901214"> <div itemprop="name">Single-Cell Transcriptome Profiles Reveal Fibrocytes as Potential Targets of Cell Therapies for Abdominal Aortic Aneurysm.</div> </a> <div itemprop="about">Frontiers in cardiovascular medicine</div> <div itemprop="author">Li B,Song X,Guo W,Hou Y,Hu H,Ge W,Fan T,Han Z,Li Z,Yang P,Gao R,Zhao H,Wang J</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to determine the roles of different vascular and immune cells in abdominal aortic aneurysm formation and pathogenesis.</div> <div itemprodp="datePublished">Wed Dec 15 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33386611"> <div itemprop="name">Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice.</div> </a> <div itemprop="about">Muscle & nerve</div> <div itemprop="author">Kawanishi N,Machida S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34671058"> <div itemprop="name">Differential activation of Ca<sup>2+</sup> influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.</div> </a> <div itemprop="about">NPJ Regenerative medicine</div> <div itemprop="author">Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 20 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33420041"> <div itemprop="name">Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Dubois V,Chatagnon J,Thiriard A,Bauderlique-Le Roy H,Debrie AS,Coutte L,Locht C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33420041"> <div itemprop="name">Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage.</div> </a> <div itemprop="about">NPJ vaccines</div> <div itemprop="author">Dubois V,Chatagnon J,Thiriard A,Bauderlique-Le Roy H,Debrie AS,Coutte L,Locht C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 08 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34103524"> <div itemprop="name">Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33516262"> <div itemprop="name">The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jan 30 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34023385"> <div itemprop="name">NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Larson-Casey JL,Gu L,Kang J,Dhyani A,Carter AB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34812145"> <div itemprop="name">The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33795658"> <div itemprop="name">A decrease in NAD<sup>+</sup> contributes to the loss of osteoprogenitors and bone mass with aging.</div> </a> <div itemprop="about">NPJ aging and mechanisms of disease</div> <div itemprop="author">Kim HN,Ponte F,Warren A,Ring R,Iyer S,Han L,Almeida M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33557007"> <div itemprop="name">Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 04 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34815397"> <div itemprop="name">G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34815397"> <div itemprop="name">G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.</div> <div itemprodp="datePublished">Tue Nov 23 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33632814"> <div itemprop="name">Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury.</div> </a> <div itemprop="about">eNeuro</div> <div itemprop="author">Pelisch N,Rosas Almanza J,Stehlik KE,Aperi BV,Kroner A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 18 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33778195"> <div itemprop="name">T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Yang X,Zhou F,Yuan P,Dou G,Liu X,Liu S,Wang X,Jin R,Dong Y,Zhou J,Lv Y,Deng Z,Liu S,Chen X,Han Y,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33778195"> <div itemprop="name">T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.</div> </a> <div itemprop="about">Bioactive materials</div> <div itemprop="author">Yang X,Zhou F,Yuan P,Dou G,Liu X,Liu S,Wang X,Jin R,Dong Y,Zhou J,Lv Y,Deng Z,Liu S,Chen X,Han Y,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33921854"> <div itemprop="name">Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Rubinstein L,Paul AM,Houseman C,Abegaz M,Tabares Ruiz S,O'Neil N,Kunis G,Ofir R,Cohen J,Ronca AE,Globus RK,Tahimic CGT</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34084287"> <div itemprop="name">Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes.</div> </a> <div itemprop="about">Journal of extracellular vesicles</div> <div itemprop="author">Zheng C,Sui B,Zhang X,Hu J,Chen J,Liu J,Wu D,Ye Q,Xiang L,Qiu X,Liu S,Deng Z,Zhou J,Liu S,Shi S,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34084287"> <div itemprop="name">Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes.</div> </a> <div itemprop="about">Journal of extracellular vesicles</div> <div itemprop="author">Zheng C,Sui B,Zhang X,Hu J,Chen J,Liu J,Wu D,Ye Q,Xiang L,Qiu X,Liu S,Deng Z,Zhou J,Liu S,Shi S,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34280086"> <div itemprop="name">Distinct skeletal stem cell types orchestrate long bone skeletogenesis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ambrosi TH,Sinha R,Steininger HM,Hoover MY,Murphy MP,Koepke LS,Wang Y,Lu WJ,Morri M,Neff NF,Weissman IL,Longaker MT,Chan CK</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33979628"> <div itemprop="name">Integrated OMICs unveil the bone-marrow microenvironment in human leukemia.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Passaro D,Garcia-Albornoz M,Diana G,Chakravarty P,Ariza-McNaughton L,Batsivari A,Borràs-Eroles C,Abarrategi A,Waclawiczek A,Ombrato L,Malanchi I,Gribben J,Bonnet D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 11 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34446716"> <div itemprop="name">PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 26 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34583010"> <div itemprop="name">Cardiac-derived TGF-β1 confers resistance to diet-induced obesity through the regulation of adipocyte size and function.</div> </a> <div itemprop="about">Molecular metabolism</div> <div itemprop="author">Longenecker JZ,Petrosino JM,Martens CR,Hinger SA,Royer CJ,Dorn LE,Branch DA,Serrano J,Stanford KI,Kyriazis GA,Baskin KK,Accornero F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34131204"> <div itemprop="name">Determining the effect of aging, recovery time, and post-stroke memantine treatment on delayed thalamic gliosis after cortical infarct.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kim GS,Stephenson JM,Al Mamun A,Wu T,Goss MG,Min JW,Li J,Liu F,Marrelli SP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 15 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34712245"> <div itemprop="name">Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 10 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34923976"> <div itemprop="name">A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases.</div> </a> <div itemprop="about">Journal of nanobiotechnology</div> <div itemprop="author">Qiu N,Yang X,Zhang Y,Zhang J,Ji J,Zhang Y,Kong X,Xi Y,Liu D,Ye L,Zhai G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Dec 19 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34154608"> <div itemprop="name">Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Chen KE,Lainez NM,Nair MG,Coss D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33490981"> <div itemprop="name">Quantitative <i>in vivo</i> assessment of amyloid-beta phagocytic capacity in an Alzheimer's disease mouse model.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Lau SF,Wu W,Seo H,Fu AKY,Ip NY</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33974566"> <div itemprop="name">Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Falach R,Bar-On L,Lazar S,Kadar T,Mazor O,Aftalion M,Gur D,Evgy Y,Shifman O,Aminov T,Israeli O,Cohen-Gihon I,Zaide G,Gutman H,Vagima Y,Makdasi E,Stein D,Rosenfeld R,Alcalay R,Zahavy E,Levy H,Glinert I,Ben-Shmuel A,Israely T,Melamed S,Politi B,Achdout H,Yitzhaki S,Kronman C,Sabo T</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33668422"> <div itemprop="name">The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Seidenberg J,Stellato M,Hukara A,Ludewig B,Klingel K,Distler O,Błyszczuk P,Kania G</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to demonstrate that Fosl-2 regulates autophagocytosis and the TGF-β-Fosl-2-autophagy axis controls differentiation of cardiac fibroblasts.</div> <div itemprodp="datePublished">Sat Feb 13 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34863353"> <div itemprop="name">A two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Jiang W,Shi L,Cai L,Wang X,Li J,Li H,Liang J,Gu Q,Ji G,Li J,Liu L,Sun M</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to suggest that the developed vaccine can elicit a multifaceted immune response and induce robust viral clearance in the URT, which makes it a potential vaccine for preventing disease and infection of SARS-CoV-2.</div> <div itemprodp="datePublished">Tue Dec 14 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33852855"> <div itemprop="name">Chronic stress physically spares but functionally impairs innate-like invariant T cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T (iNKT) cells.</div> <div itemprodp="datePublished">Tue Apr 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34330273"> <div itemprop="name">The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways.</div> </a> <div itemprop="about">BMC biology</div> <div itemprop="author">Coudert L,Osseni A,Gangloff YG,Schaeffer L,Leblanc P</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to show for the first time that Hrs/Hgs is a master regulator that modulates myogenesis at different levels through the control of trafficking, signaling, and degradation pathways.</div> <div itemprodp="datePublished">Fri Jul 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34551293"> <div itemprop="name">CCR2 deficiency alters activation of microglia subsets in traumatic brain injury.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Somebang K,Rudolph J,Imhof I,Li L,Niemi EC,Shigenaga J,Tran H,Gill TM,Lo I,Zabel BA,Schmajuk G,Wipke BT,Gyoneva S,Jandreski L,Craft M,Benedetto G,Plowey ED,Charo I,Campbell J,Ye CJ,Panter SS,Nakamura MC,Eckalbar W,Hsieh CL</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to define the heterogeneity of microglia and macrophage phenotypes during TBI in wild-type (WT) mice and Ccr2-/- mice, which lack macrophage influx following TBI and are resistant to brain damage.</div> <div itemprodp="datePublished">Tue Sep 21 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34413860"> <div itemprop="name">Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ma M,Li G,Qi M,Jiang W,Zhou R</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to show that NLRP3 in myeloid cells promoted the development and progression of allergic asthma in an inflammasome-dependent manner.</div> <div itemprodp="datePublished">Fri Dec 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33692790"> <div itemprop="name">Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33462210"> <div itemprop="name">Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,Prosper F,Garayoa M,Ballestar E</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to study the efficacy of targeting methylation in myeloma bone disease.</div> <div itemprodp="datePublished">Mon Jan 18 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33618716"> <div itemprop="name">Systemic administration of β-glucan induces immune training in microglia.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Heng Y,Zhang X,Borggrewe M,van Weering HRJ,Brummer ML,Nijboer TW,Joosten LAB,Netea MG,Boddeke EWGM,Laman JD,Eggen BJL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 22 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33795678"> <div itemprop="name">Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ding X,Wang J,Huang M,Chen Z,Liu J,Zhang Q,Zhang C,Xiang Y,Zen K,Li L</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to investigate the role of SIRPα in neurodegeneration.</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34925367"> <div itemprop="name">Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to demonstrated that CD8+ T-lymphocytes play a key role in supporting the survival of reparative MoMFs during liver healing trough ICOS/ICOSL-mediated signaling.</div> <div itemprodp="datePublished">Mon Feb 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32702313"> <div itemprop="name">Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.</div> <div itemprodp="datePublished">Thu Aug 06 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32970988"> <div itemprop="name">Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Chikina AS,Nadalin F,Maurin M,San-Roman M,Thomas-Bonafos T,Li XV,Lameiras S,Baulande S,Henri S,Malissen B,Lacerda Mariano L,Barbazan J,Blander JM,Iliev ID,Matic Vignjevic D,Lennon-Duménil AM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32615086"> <div itemprop="name">CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Oguri Y,Shinoda K,Kim H,Alba DL,Bolus WR,Wang Q,Brown Z,Pradhan RN,Tajima K,Yoneshiro T,Ikeda K,Chen Y,Cheang RT,Tsujino K,Kim CR,Greiner VJ,Datta R,Yang CD,Atabai K,McManus MT,Koliwad SK,Spiegelman BM,Kajimura S</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to investigate if CD81 functions as a key sensor of external inputs and if it controls beige adipocyte progenitor cells proliferation and whole-body energy homeostasis.</div> <div itemprodp="datePublished">Thu Aug 06 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32673566"> <div itemprop="name">The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 18 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32989251"> <div itemprop="name">STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Paris AJ,Hayer KE,Oved JH,Avgousti DC,Toulmin SA,Zepp JA,Zacharias WJ,Katzen JB,Basil MC,Kremp MM,Slamowitz AR,Jayachandran S,Sivakumar A,Dai N,Wang P,Frank DB,Eisenlohr LC,Cantu E,Beers MF,Weitzman MD,Morrisey EE,Worthen GS</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to elucidate repair mechanisms of proliferation and trandifferentiation of type II alveolar pneumocytes (AT2 cells) into type I alveolar pneumocytes (AT1 cells) after acute lung injury.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31794021"> <div itemprop="name">Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.</div> </a> <div itemprop="about">Brain : a journal of neurology</div> <div itemprop="author">Koronyo-Hamaoui M,Sheyn J,Hayden EY,Li S,Fuchs DT,Regis GC,Lopes DHJ,Black KL,Bernstein KE,Teplow DB,Fuchs S,Koronyo Y,Rentsendorj A</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to explore the impact of selective and transient angiotensin-converting enzyme overexpression on macrophage behaviour and the relative contribution of bone marrow-derived ACE10 macrophages, but not microglia, in attenuating disease progression.</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31983527"> <div itemprop="name">Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease.</div> </a> <div itemprop="about">The Journal of allergy and clinical immunology</div> <div itemprop="author">Shears RK,Jacques LC,Naylor G,Miyashita L,Khandaker S,Lebre F,Lavelle EC,Grigg J,French N,Neill DR,Kadioglu A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32084360"> <div itemprop="name">Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Marsh T,Kenific CM,Suresh D,Gonzalez H,Shamir ER,Mei W,Tankka A,Leidal AM,Kalavacherla S,Woo K,Werb Z,Debnath J</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to reveal that autophagy gene expression inversely correlates with pro-metastatic differentiation signatures and predicts overall and distant metastasis-free survival.</div> <div itemprodp="datePublished">Mon Mar 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31392723"> <div itemprop="name">Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32092351"> <div itemprop="name">Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis.</div> </a> <div itemprop="about">The Journal of investigative dermatology</div> <div itemprop="author">Peters F,Tellkamp F,Brodesser S,Wachsmuth E,Tosetti B,Karow U,Bloch W,Utermöhlen O,Krönke M,Niessen CM</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to show that epidermal loss of ceramide synthase 4 first disturbs epidermal lipid metabolism and adult epidermal barrier function, ultimately resulting in chronic skin barrier disease characterized by acanthosis, hyperkeratosis, and immune cell accumulation.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32098763"> <div itemprop="name">Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Gagniac L,Rusidzé M,Boudou F,Cagnet S,Adlanmerini M,Jeannot P,Gaide N,Giton F,Besson A,Weyl A,Gourdy P,Raymond-Letron I,Arnal JF,Brisken C,Lenfant F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33330583"> <div itemprop="name">Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice.</div> </a> <div itemprop="about">Frontiers in nutrition</div> <div itemprop="author">Chei S,Oh HJ,Lee K,Jin H,Lee JY,Lee BY</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the deleterious roles of immunosenescent cells in the immune system.</div> <div itemprodp="datePublished">Fri Dec 18 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33330583"> <div itemprop="name">Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice.</div> </a> <div itemprop="about">Frontiers in nutrition</div> <div itemprop="author">Chei S,Oh HJ,Lee K,Jin H,Lee JY,Lee BY</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the deleterious roles of immunosenescent cells in the immune system.</div> <div itemprodp="datePublished">Fri Dec 18 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32012286"> <div itemprop="name">Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Li J,Wang T,Li C,Wang Z,Wang P,Zheng L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32012286"> <div itemprop="name">Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Li J,Wang T,Li C,Wang Z,Wang P,Zheng L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33132837"> <div itemprop="name">Detection of Synaptic Proteins in Microglia by Flow Cytometry.</div> </a> <div itemprop="about">Frontiers in molecular neuroscience</div> <div itemprop="author">Brioschi S,d'Errico P,Amann LS,Janova H,Wojcik SM,Meyer-Luehmann M,Rajendran L,Wieghofer P,Paolicelli RC,Biber K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 03 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32963751"> <div itemprop="name">Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.</div> </a> <div itemprop="about">Therapeutic advances in chronic disease</div> <div itemprop="author">Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Apr 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32186753"> <div itemprop="name">Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33219226"> <div itemprop="name">Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Okazaki K,Anzawa H,Liu Z,Ota N,Kitamura H,Onodera Y,Alam MM,Matsumaru D,Suzuki T,Katsuoka F,Tadaka S,Motoike I,Watanabe M,Hayasaka K,Sakurada A,Okada Y,Yamamoto M,Suzuki T,Kinoshita K,Sekine H,Motohashi H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 20 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33328477"> <div itemprop="name">Eosinophils improve cardiac function after myocardial infarction.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 16 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32346042"> <div itemprop="name">Ly6c<sup>Lo</sup> non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32731354"> <div itemprop="name">Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Kuziel G,Thompson V,D'Amato JV,Arendt LM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that chronic inflammation induced by CCL2 significantly enhances tumor growth and promotes the formation of a desmoplastic stroma through early recruitment of macrophages and fibrocytes into the tumor microenvironment.</div> <div itemprodp="datePublished">Tue Jul 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32731354"> <div itemprop="name">Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Kuziel G,Thompson V,D'Amato JV,Arendt LM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that chronic inflammation induced by CCL2 significantly enhances tumor growth and promotes the formation of a desmoplastic stroma through early recruitment of macrophages and fibrocytes into the tumor microenvironment.</div> <div itemprodp="datePublished">Tue Jul 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33012781"> <div itemprop="name">Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Yang L,Liu G,Li X,Xia Z,Wang Y,Lin W,Zhang W,Zhang W,Li X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Oct 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32385263"> <div itemprop="name">A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33263277"> <div itemprop="name">Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32750044"> <div itemprop="name">Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Markworth JF,Brown LA,Lim E,Floyd C,Larouche J,Castor-Macias JA,Sugg KB,Sarver DC,Macpherson PC,Davis C,Aguilar CA,Maddipati KR,Brooks SV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32750044"> <div itemprop="name">Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Markworth JF,Brown LA,Lim E,Floyd C,Larouche J,Castor-Macias JA,Sugg KB,Sarver DC,Macpherson PC,Davis C,Aguilar CA,Maddipati KR,Brooks SV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33036616"> <div itemprop="name">Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Lowe PP,Morel C,Ambade A,Iracheta-Vellve A,Kwiatkowski E,Satishchandran A,Furi I,Cho Y,Gyongyosi B,Catalano D,Lefebvre E,Fischer L,Seyedkazemi S,Schafer DP,Szabo G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 09 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33052221"> <div itemprop="name">Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Li Y,Ritzel RM,Khan N,Cao T,He J,Lei Z,Matyas JJ,Sabirzhanov B,Liu S,Li H,Stoica BA,Loane DJ,Faden AI,Wu J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32331524"> <div itemprop="name">Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Schröder N,Schaffrath A,Welter JA,Putzka T,Griep A,Ziegler P,Brandt E,Samer S,Heneka MT,Kaddatz H,Zhan J,Kipp E,Pufe T,Tauber SC,Kipp M,Brandenburg LO</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32814714"> <div itemprop="name">Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32724083"> <div itemprop="name">Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jandke A,Melandri D,Monin L,Ushakov DS,Laing AG,Vantourout P,East P,Nitta T,Narita T,Takayanagi H,Feederle R,Hayday A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32332858"> <div itemprop="name">Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.</div> </a> <div itemprop="about">Communications biology</div> <div itemprop="author">Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32226299"> <div itemprop="name">PPARγ inhibition boosts efficacy of PD-L1 Checkpoint Blockade Immunotherapy against Murine Melanoma in a sexually dimorphic manner.</div> </a> <div itemprop="about">International journal of biological sciences</div> <div itemprop="author">Wu B,Sun X,Yuan B,Ge F,Gupta HB,Chiang HC,Li J,Hu Y,Curiel TJ,Li R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33424855"> <div itemprop="name">A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Wu CH,Gan CH,Li LH,Chang JC,Chen ST,Menon MP,Cheng SM,Yang SP,Ho CL,Chernikov OV,Lin CH,Lam Y,Hua KF</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33072626"> <div itemprop="name">CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.</div> </a> <div itemprop="about">Frontiers in cellular and infection microbiology</div> <div itemprop="author">Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 17 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33246491"> <div itemprop="name">Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 27 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32467752"> <div itemprop="name">Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.</div> </a> <div itemprop="about">Cell & bioscience</div> <div itemprop="author">Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33490963"> <div itemprop="name">Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.</div> </a> <div itemprop="about">Kidney360</div> <div itemprop="author">Zimmerman KA,Huang J,He L,Revell DZ,Li Z,Hsu JS,Fitzgibbon WR,Hazard ES,Hardiman G,Mrug M,Bell PD,Yoder BK,Saigusa T</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that Irf5 promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32198421"> <div itemprop="name">Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to show that disseminated breast cancer cells evoke phenotypic changes in lung fibroblasts, forming a supportive metastatic niche.</div> <div itemprodp="datePublished">Fri Mar 20 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32402278"> <div itemprop="name">Platelets Fuel the Inflammasome Activation of Innate Immune Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Rolfes V,Ribeiro LS,Hawwari I,Böttcher L,Rosero N,Maasewerd S,Santos MLS,Próchnicki T,Silva CMS,Wanderley CWS,Rothe M,Schmidt SV,Stunden HJ,Bertheloot D,Rivas MN,Fontes CJ,Carvalho LH,Cunha FQ,Latz E,Arditi M,Franklin BS</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to conclude that platelets provide an additional layer of regulation of inflammasomes and IL-1-driven inflammation.</div> <div itemprodp="datePublished">Tue May 12 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32019921"> <div itemprop="name">Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Tsujinaka H,Fu J,Shen J,Yu Y,Hafiz Z,Kays J,McKenzie D,Cardona D,Culp D,Peterson W,Gilger BC,Crean CS,Zhang JZ,Kanan Y,Yu W,Cleland JL,Yang M,Hanes J,Campochiaro PA</div> <div itemprop="description">12-0451-82 was used in Immunohistochemistry to report incorporation of sunitinib, a tyrosine kinase inhibitor that blocks VEGF receptors, into a non-inflammatory biodegradable polymer to generate sunitinib microparticles specially formulated to self-aggregate into a depot.</div> <div itemprodp="datePublished">Tue Feb 04 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33348616"> <div itemprop="name">Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Semba T,Sato R,Kasuga A,Suina K,Shibata T,Kohno T,Suzuki M,Saya H,Arima Y</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to develop organoid-based orthotopic and syngeneic mouse models for studies of the pathogenesis and treatment of lung adenocarcinoma.</div> <div itemprodp="datePublished">Thu Dec 17 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32290362"> <div itemprop="name">Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.</div> <div itemprodp="datePublished">Sat Apr 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31982571"> <div itemprop="name">Mesenchymal Stromal Cell-Derived Exosomes Contribute to Epithelial Regeneration in Experimental Inflammatory Bowel Disease.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Barnhoorn MC,Plug L,Jonge ESMM,Molenkamp D,Bos E,Schoonderwoerd MJA,Corver WE,van der Meulen-de Jong AE,Verspaget HW,Hawinkels LJAC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon May 10 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31402172"> <div itemprop="name">GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Luan HH,Wang A,Hilliard BK,Carvalho F,Rosen CE,Ahasic AM,Herzog EL,Kang I,Pisani MA,Yu S,Zhang C,Ring AM,Young LH,Medzhitov R</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show that GDF15 coordinates tolerance to inflammatory damage through regulation of triglyceride metabolism.</div> <div itemprodp="datePublished">Thu Aug 22 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31609245"> <div itemprop="name">Increased flux through the mevalonate pathway mediates fibrotic repair without injury.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Larson-Casey JL,Vaid M,Gu L,He C,Cai GQ,Ding Q,Davis D,Berryhill TF,Wilson LS,Barnes S,Neighbors JD,Hohl RJ,Zimmerman KA,Yoder BK,Longhini ALF,Hanumanthu VS,Surolia R,Antony VB,Carter AB</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to increased activation of the small GTPase Rac1.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30948627"> <div itemprop="name">Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Zimmerman KA,Bentley MR,Lever JM,Li Z,Crossman DK,Song CJ,Liu S,Crowley MR,George JF,Mrug M,Yoder BK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to indicate that there is a conserved population of innate immune cells across multiple species that have been defined as resident macrophages in the mouse.</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31515941"> <div itemprop="name">The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Hashwah H,Bertram K,Stirm K,Stelling A,Wu CT,Kasser S,Manz MG,Theocharides AP,Tzankov A,Müller A</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show that a subset of diffuse large B-cell lymphoma(DLBCL) cases have evolved mechanisms that ensure constitutive activation of the IL-6 signaling pathway, i.e., the expression of both chains of the IL-6R, the expression of the cytokine itself, and the mutational inactivation of a negative regulator of IL-6 signaling, SOCS1.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31648279"> <div itemprop="name">The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30246247"> <div itemprop="name">Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells.</div> </a> <div itemprop="about">Journal of cellular physiology</div> <div itemprop="author">Siavashi V,Nassiri SM,Rahbarghazi R,Mohseni Z,Sharifi AM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30612298"> <div itemprop="name">Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.</div> </a> <div itemprop="about">Journal of cell communication and signaling</div> <div itemprop="author">Cervantes-Villagrana RD,Color-Aparicio VM,Reyes-Cruz G,Vázquez-Prado J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31316601"> <div itemprop="name">Altered expression of leptin and leptin receptor in the development of immune-mediated aplastic anemia in mice.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Yin X,Yang J,Liu Y,Zhang J,Xin C,Zhao H,Wang W,Shi X,Cui Z,Li G,Zhao C,Liu X</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to develop an aplastic anemia mouse model in order to study the role of leptin and leptin receptor in the differentiation of mesenchymal stem cells into adipocytes.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31354896"> <div itemprop="name">Antiallodynic Effects of Cannabinoid Receptor 2 (CB<sub>2</sub>R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.</div> </a> <div itemprop="about">Pain research & management</div> <div itemprop="author">Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 16 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30998512"> <div itemprop="name">Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.</div> </a> <div itemprop="about">Anti-cancer drugs</div> <div itemprop="author">Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30998512"> <div itemprop="name">Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.</div> </a> <div itemprop="about">Anti-cancer drugs</div> <div itemprop="author">Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30704498"> <div itemprop="name">CSF1R antagonism limits local restimulation of antiviral CD8<sup>+</sup> T cells during viral encephalitis.</div> </a> <div itemprop="about">Journal of neuroinflammation</div> <div itemprop="author">Funk KE,Klein RS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 31 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31287416"> <div itemprop="name">Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Lim J,Park H,Heisler J,Maculins T,Roose-Girma M,Xu M,Mckenzie B,van Lookeren Campagne M,Newton K,Murthy A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 09 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31253842"> <div itemprop="name">The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 28 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31533035"> <div itemprop="name">The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.</div> <div itemprodp="datePublished">Tue Sep 17 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31619022"> <div itemprop="name">Lifelong n-3 Polyunsaturated Fatty Acid Exposure Modulates Size of Mammary Epithelial Cell Populations and Expression of Caveolae Resident Proteins in Fat-1 Mice.</div> </a> <div itemprop="about">Nutrients</div> <div itemprop="author">Hillyer LM,Kang JX,Ma DWL</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to provide mechanistic evidence by which omega-3 polyunsaturated fatty acids modifies early mammary gland development that may potentially reduce breast cancer risk later in life.</div> <div itemprodp="datePublished">Tue Oct 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31779710"> <div itemprop="name">MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Nov 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30711545"> <div itemprop="name">Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.</div> </a> <div itemprop="about">Cellular and molecular gastroenterology and hepatology</div> <div itemprop="author">Cipriani G,Terhaar ML,Eisenman ST,Ji S,Linden DR,Wright AM,Sha L,Ordog T,Szurszewski JH,Gibbons SJ,Farrugia G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31631836"> <div itemprop="name">Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Walsh CM,Hill RZ,Schwendinger-Schreck J,Deguine J,Brock EC,Kucirek N,Rifi Z,Wei J,Gronert K,Brem RB,Barton GM,Bautista DM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 21 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31787973"> <div itemprop="name">Exposure to Cigarette Smoke Augments Post-ischemic Brain Injury and Inflammation via Mobilization of Neutrophils and Monocytes.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Li H,Li X,Gao S,Wang D,Gao X,Li Y,Wang X,Cui Z,Ma H,Liu Q,Li M</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that cigarette smoke-induced mobilization of peripheral neutrophils and monocytes augments ischemic brain injury.</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30796225"> <div itemprop="name">Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.</div> <div itemprodp="datePublished">Fri Feb 22 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30897318"> <div itemprop="name">Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model.</div> </a> <div itemprop="about">Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology</div> <div itemprop="author">Silva C,Sampaio-Pinto V,Andrade S,Rodrigues I,Costa R,Guerreiro S,Carvalho E,Pinto-do-Ó P,Nascimento DS,Soares R</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the angiogenic and metabolic gene expression profile of endothelial cells from a diabetes model.</div> <div itemprodp="datePublished">Wed Apr 03 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31478830"> <div itemprop="name">FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,Kolev VN,Weaver DT,Pachter JA,Győrffy B,McHale MT,Connolly DC,Molinolo A,Stupack DG,Schlaepfer DD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 03 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30809231"> <div itemprop="name">Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8<sup>+</sup> Dendritic Cells.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.</div> <div itemprodp="datePublished">Tue Oct 27 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30628695"> <div itemprop="name">Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30988300"> <div itemprop="name">PDGFRα<sup>+</sup> stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Joshi PA,Waterhouse PD,Kasaian K,Fang H,Gulyaeva O,Sul HS,Boutros PC,Khokha R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 15 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30841538"> <div itemprop="name">Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29875463"> <div itemprop="name">Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Wang G,Biswas AK,Ma W,Kandpal M,Coker C,Grandgenett PM,Hollingsworth MA,Jain R,Tanji K,Lόpez-Pintado S,Borczuk A,Hebert D,Jenkitkasemwong S,Hojyo S,Davuluri RV,Knutson MD,Fukada T,Acharyya S</div> <div itemprop="description">12-0451 was used in Magnetic cell separation to identify the metal-ion transporter ZRT- and IRT-like protein 14 as a critical mediator of cancer-induced cachexia.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30069044"> <div itemprop="name">A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Montoro DT,Haber AL,Biton M,Vinarsky V,Lin B,Birket SE,Yuan F,Chen S,Leung HM,Villoria J,Rogel N,Burgin G,Tsankov AM,Waghray A,Slyper M,Waldman J,Nguyen L,Dionne D,Rozenblatt-Rosen O,Tata PR,Mou H,Shivaraju M,Bihler H,Mense M,Tearney GJ,Rowe SM,Engelhardt JF,Regev A,Rajagopal J</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to study the cellular composition and hierarchy of the murine tracheal epithelium.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29909986"> <div itemprop="name">Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29343440"> <div itemprop="name">Chanzyme TRPM7 Mediates the Ca<sup>2+</sup> Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 16 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29466755"> <div itemprop="name">Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Hu G,Cui K,Fang D,Hirose S,Wang X,Wangsa D,Jin W,Ried T,Liu P,Zhu J,Rothenberg EV,Zhao K</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to find that abrupt genome-wide changes at all three levels of chromatin organization occur during the transition from double-negative stage 2 (DN2) to DN3, accompanying the T lineage commitment.</div> <div itemprodp="datePublished">Tue Feb 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29452935"> <div itemprop="name">E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 20 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30332632"> <div itemprop="name">The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Mollaoglu G,Jones A,Wait SJ,Mukhopadhyay A,Jeong S,Arya R,Camolotto SA,Mosbruger TL,Stubben CJ,Conley CJ,Bhutkar A,Vahrenkamp JM,Berrett KC,Cessna MH,Lane TE,Witt BL,Salama ME,Gertz J,Jones KB,Snyder EL,Oliver TG</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to identify that SOX2 and NKX2-1 lineage-defining transcription factors regulate tumour immune microenvironment and determine lung cancer cell fate.</div> <div itemprodp="datePublished">Tue Oct 16 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29784918"> <div itemprop="name">Early lineage segregation of multipotent embryonic mammary gland progenitors.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the timing and mechanisms mediating early lineage segregation of multipotent progenitors during mammary gland development.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30290177"> <div itemprop="name">Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Verma M,Asakura Y,Murakonda BSR,Pengo T,Latroche C,Chazaud B,McLoon LK,Asakura A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29728652"> <div itemprop="name">Defective germline reprogramming rewires the spermatogonial transcriptome.</div> </a> <div itemprop="about">Nature structural & molecular biology</div> <div itemprop="author">Vasiliauskaitė L,Berrens RV,Ivanova I,Carrieri C,Reik W,Enright AJ,O'Carroll D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29891135"> <div itemprop="name">11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.</div> </a> <div itemprop="about">Journal of autoimmunity</div> <div itemprop="author">Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29449644"> <div itemprop="name">Inhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Xie SJ,Li JH,Chen HF,Tan YY,Liu SR,Zhang Y,Xu H,Yang JH,Liu S,Zheng LL,Huang MB,Guo YH,Zhang Q,Zhou H,Qu LH</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29789715"> <div itemprop="name">Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Vorhagen S,Kleefisch D,Persa OD,Graband A,Schwickert A,Saynisch M,Leitges M,Niessen CM,Iden S</div> <div itemprop="description">12-0451 was used in Immunohistochemistry to demonstrate that Par3 and aPKCλ cooperate to promote skin tumor initiation and progression, likely through sustaining growth, survival, and inflammatory signaling.</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30306644"> <div itemprop="name">VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Borggrewe M,Grit C,Den Dunnen WFA,Burm SM,Bajramovic JJ,Noelle RJ,Eggen BJL,Laman JD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30335499"> <div itemprop="name">Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.</div> </a> <div itemprop="about">American journal of physiology. Lung cellular and molecular physiology</div> <div itemprop="author">Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30010933"> <div itemprop="name">MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.</div> </a> <div itemprop="about">Human molecular genetics</div> <div itemprop="author">Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29512716"> <div itemprop="name">High fish oil diet promotes liver inflammation and activates the complement system.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Jin H,Yan C,Xiao T,Yan N,Xu J,Zhou L,Zhou X,Shao Q,Xia S</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the effects of a high fish oil diet in mice, thus revealing induced inflammation and activation of the complement system in the liver.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33817078"> <div itemprop="name">mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Open life sciences</div> <div itemprop="author">Wang H,Xiao Y,Su L,Cui N,Liu D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jan 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29500407"> <div itemprop="name">MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Clemente C,Rius C,Alonso-Herranz L,Martín-Alonso M,Pollán Á,Camafeita E,Martínez F,Mota RA,Núñez V,Rodríguez C,Seiki M,Martínez-González J,Andrés V,Ricote M,Arroyo AG</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29371665"> <div itemprop="name">Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Tosic M,Allen A,Willmann D,Lepper C,Kim J,Duteil D,Schüle R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 25 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30485818"> <div itemprop="name">Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Ruiz-Estevez M,Staats J,Paatela E,Munson D,Katoku-Kikyo N,Yuan C,Asakura Y,Hostager R,Kobayashi H,Asakura A,Kikyo N</div> <div itemprop="description">12-0451-82 was used in Magnetic cell separation to study the role of Fkbp5 in myogenesis.</div> <div itemprodp="datePublished">Tue Nov 27 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30254630"> <div itemprop="name">Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Sep 25 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30181538"> <div itemprop="name">Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Zwick RK,Rudolph MC,Shook BA,Holtrup B,Roth E,Lei V,Van Keymeulen A,Seewaldt V,Kwei S,Wysolmerski J,Rodeheffer MS,Horsley V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30455690"> <div itemprop="name">ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29934585"> <div itemprop="name">Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 22 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30429478"> <div itemprop="name">Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yuzhalin AE,Gordon-Weeks AN,Tognoli ML,Jones K,Markelc B,Konietzny R,Fischer R,Muth A,O'Neill E,Thompson PR,Venables PJ,Kessler BM,Lim SY,Muschel RJ</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to examine the potential for peptidylarginine deiminase 4-dependant citrullination to drive the progression of colorectal cancer liver metastasis.</div> <div itemprodp="datePublished">Wed Nov 14 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29515165"> <div itemprop="name">Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to indicate that Rap1 is essential to maintain the immunomodulatory function of MSCs.</div> <div itemprodp="datePublished">Wed Mar 07 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29723263"> <div itemprop="name">Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Divan A,Casselli T,Narayanan SA,Mukherjee S,Zawieja DC,Watt JA,Brissette CA,Newell-Rogers MK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate that there are aspects of Borrelia burgdorferi meningeal infection that can be modelled in laboratory mice.</div> <div itemprodp="datePublished">Mon Aug 06 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30275453"> <div itemprop="name">Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Igarashi Y,Nawaz A,Kado T,Bilal M,Kuwano T,Yamamoto S,Sasahara M,Jiuxiang X,Inujima A,Koizumi K,Imura J,Shibahara N,Usui I,Fujisaka S,Tobe K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30365542"> <div itemprop="name">A patient derived xenograft model of cervical cancer and cervical dysplasia.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Larmour LI,Cousins FL,Teague JA,Deane JA,Jobling TW,Gargett CE</div> <div itemprop="description">12-0451 was used in Immunohistochemistry to develop a patient derived xenograft model of cervical cancer and cervical dysplasia using the subrenal capsule.</div> <div itemprodp="datePublished">Fri Mar 29 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29968769"> <div itemprop="name">Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ridinger J,Koeneke E,Kolbinger FR,Koerholz K,Mahboobi S,Hellweg L,Gunkel N,Miller AK,Peterziel H,Schmezer P,Hamacher-Brady A,Witt O,Oehme I</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the role of HDAC10 in lysosomal exocytosis and DNA repair.</div> <div itemprodp="datePublished">Tue Jul 03 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29429943"> <div itemprop="name">CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Wakabayashi T,Naito H,Suehiro JI,Lin Y,Kawaji H,Iba T,Kouno T,Ishikawa-Kato S,Furuno M,Takara K,Muramatsu F,Weizhen J,Kidoya H,Ishihara K,Hayashizaki Y,Nishida K,Yoder MC,Takakura N</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29017059"> <div itemprop="name">Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Reyna DE,Garner TP,Lopez A,Kopp F,Choudhary GS,Sridharan A,Narayanagari SR,Mitchell K,Dong B,Bartholdy BA,Walensky LD,Verma A,Steidl U,Gavathiotis E</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to identify BTSA1, a pharmacologically optimised BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.</div> <div itemprodp="datePublished">Mon Oct 09 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28218906"> <div itemprop="name">Differential cytokine contributions of perivascular haematopoietic stem cell niches.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27889319"> <div itemprop="name">Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Latil M,Nassar D,Beck B,Boumahdi S,Wang L,Brisebarre A,Dubois C,Nkusi E,Lenglez S,Checinska A,Vercauteren Drubbel A,Devos M,Declercq W,Yi R,Blanpain C</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the importance of specific chromatin and transcriptional states in differentially priming tumours to epithelial-to-mesenchymal transition.</div> <div itemprodp="datePublished">Thu Feb 02 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28330582"> <div itemprop="name">Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28134623"> <div itemprop="name">A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29018045"> <div itemprop="name">PTEN drives Th17 cell differentiation by preventing IL-2 production.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show that PTEN plays a key role in Th17 cell differentiation by blocking IL-2 expression.</div> <div itemprodp="datePublished">Mon Nov 06 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28566332"> <div itemprop="name">Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28630327"> <div itemprop="name">Virus-induced inflammasome activation is suppressed by prostaglandin D<sub>2</sub>/DP1 signaling.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Vijay R,Fehr AR,Janowski AM,Athmer J,Wheeler DL,Grunewald M,Sompallae R,Kurup SP,Meyerholz DK,Sutterwala FS,Narumiya S,Perlman S</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the role of Prostaglandin D2 signalling in optimal microglia/macrophage activation and interferon expression after infection with a neurotropic coronavirus.</div> <div itemprodp="datePublished">Mon Jul 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28716934"> <div itemprop="name">Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Tejada MA,Montilla-García A,Cronin SJ,Cikes D,Sánchez-Fernández C,González-Cano R,Ruiz-Cantero MC,Penninger JM,Vela JM,Baeyens JM,Cobos EJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29187227"> <div itemprop="name">Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.</div> </a> <div itemprop="about">Breast cancer research : BCR</div> <div itemprop="author">Chamberlin T,D'Amato JV,Arendt LM</div> <div itemprop="description"></div> <div itemprodp="datePublished">Wed Nov 29 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28273719"> <div itemprop="name">Depletion of microglia exacerbates postischemic inflammation and brain injury.</div> </a> <div itemprop="about">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</div> <div itemprop="author">Jin WN,Shi SX,Li Z,Li M,Wood K,Gonzales RJ,Liu Q</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27492949"> <div itemprop="name">An atypical role for the myeloid receptor Mincle in central nervous system injury.</div> </a> <div itemprop="about">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</div> <div itemprop="author">Arumugam TV,Manzanero S,Furtado M,Biggins PJ,Hsieh YH,Gelderblom M,MacDonald KP,Salimova E,Li YI,Korn O,Dewar D,Macrae IM,Ashman RB,Tang SC,Rosenthal NA,Ruitenberg MJ,Magnus T,Wells CA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28356527"> <div itemprop="name">Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.</div> <div itemprodp="datePublished">Mon May 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28485322"> <div itemprop="name">Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8<sup>+</sup> T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Chinese medical journal</div> <div itemprop="author">Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 20 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27577867"> <div itemprop="name">Cornea lymphatics drive the CD8<sup>+</sup> T-cell response to herpes simplex virus-1.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Gurung HR,Carr MM,Carr DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27860312"> <div itemprop="name">Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28513874"> <div itemprop="name">β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Vafaei R,Nassiri SM,Siavashi V</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28497488"> <div itemprop="name">The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.</div> </a> <div itemprop="about">The Prostate</div> <div itemprop="author">Colinot DL,Garbuz T,Bosland MC,Wang L,Rice SE,Sullivan WJ,Arrizabalaga G,Jerde TJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jul 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28778445"> <div itemprop="name">Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.</div> </a> <div itemprop="about">Journal of neuroimmunology</div> <div itemprop="author">Benedek G,Zhang J,Nguyen H,Kent G,Seifert HA,Davin S,Stauffer P,Vandenbark AA,Karstens L,Asquith M,Offner H</div> <div itemprop="description"></div> <div itemprodp="datePublished">Fri Sep 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28986576"> <div itemprop="name">Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kawakubo M,Cunningham TJ,Demehri S,Manstein D</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to assess the utility of ablative fractional photothermolysis for treating oncological indications.</div> <div itemprodp="datePublished">Fri Oct 06 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28332979"> <div itemprop="name">The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Xiong G,Hindi SM,Mann AK,Gallot YS,Bohnert KR,Cavener DR,Whittemore SR,Kumar A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 23 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28453382"> <div itemprop="name">Flow cytometric single cell analysis reveals heterogeneity between adipose depots.</div> </a> <div itemprop="about">Adipocyte</div> <div itemprop="author">Boumelhem BB,Assinder SJ,Bell-Anderson KS,Fraser ST</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to report a system for analyzing live adipocytes from different adipose depots in the adult mouse.</div> <div itemprodp="datePublished">Mon Apr 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28924369"> <div itemprop="name">IL-12 Influence mTOR to Modulate CD8<sup>+</sup> T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">International journal of medical sciences</div> <div itemprop="author">Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate whether the mTOR signalling pathway regulates the proliferation and differentiation of CD8+ T cells in an invasive pulmonary aspergillosis mouse model.</div> <div itemprodp="datePublished">Mon May 21 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29162901"> <div itemprop="name">microRNA-449a modulates medullary thymic epithelial cell differentiation.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Chen P,Zhang H,Sun X,Hu Y,Jiang W,Liu Z,Liu S,Zhang X</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 21 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28570274"> <div itemprop="name">Tristetraprolin expression by keratinocytes controls local and systemic inflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Andrianne M,Assabban A,La C,Mogilenko D,Salle DS,Fleury S,Doumont G,Van Simaeys G,Nedospasov SA,Blackshear PJ,Dombrowicz D,Goriely S,Van Maele L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 02 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28837150"> <div itemprop="name">Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Bingel C,Koeneke E,Ridinger J,Bittmann A,Sill M,Peterziel H,Wrobel JK,Rettig I,Milde T,Fernekorn U,Weise F,Schober A,Witt O,Oehme I</div> <div itemprop="description">12-0451-82 was used in Flow Cytometry to show that 3D growth within a bioreactor system modulates key hallmarks of cancer cells.</div> <div itemprodp="datePublished">Thu Aug 24 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28768912"> <div itemprop="name">Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to identify functionally distinct adaptive GPCR heterogeneity patternation in mice.</div> <div itemprodp="datePublished">Thu Aug 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29030607"> <div itemprop="name">CCDC88B is required for pathogenesis of inflammatory bowel disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Fodil N,Moradin N,Leung V,Olivier JF,Radovanovic I,Jeyakumar T,Flores Molina M,McFarquhar A,Cayrol R,Bozec D,Shoukry NH,Kubo M,Dimitrieva J,Louis E,Theatre E,Dahan S,Momozawa Y,Georges M,Yeretssian G,Gros P</div> <div itemprop="description">12-0451 was used in Immunofluorescence to suggest that CCDC88B has a critical function in colon inflammation and the pathogenesis of inflammatory bowel disease.</div> <div itemprodp="datePublished">Fri Oct 13 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28405519"> <div itemprop="name">The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28594896"> <div itemprop="name">Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28814662"> <div itemprop="name">Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28494939"> <div itemprop="name">Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Redgrave RE,Tual-Chalot S,Davison BJ,Singh E,Hall D,Amirrasouli MM,Gilchrist D,Medvinsky A,Arthur HM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 09 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28165063"> <div itemprop="name">Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K</div> <div itemprop="description">12-0451 was used in Western Blotting to help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD.</div> <div itemprodp="datePublished">Mon Feb 06 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26935695"> <div itemprop="name">High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Beyaz S,Mana MD,Roper J,Kedrin D,Saadatpour A,Hong SJ,Bauer-Rowe KE,Xifaras ME,Akkad A,Arias E,Pinello L,Katz Y,Shinagare S,Abu-Remaileh M,Mihaylova MM,Lamming DW,Dogum R,Guo G,Bell GW,Selig M,Nielsen GP,Gupta N,Ferrone CR,Deshpande V,Yuan GC,Orkin SH,Sabatini DM,Yilmaz ÖH</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate that a high-fat diet augments the numbers and proliferation of intestinal stem-cells.</div> <div itemprodp="datePublished">Thu Mar 03 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27912060"> <div itemprop="name">The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL</div> <div itemprop="description">12-0451 was used in Immunohistochemistry-immunofluorescence to observe the role played by the Hippo pathway in suppressing anti-tumour immunity.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27019226"> <div itemprop="name">Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Esterházy D,Loschko J,London M,Jove V,Oliveira TY,Mucida D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26656646"> <div itemprop="name">Oligodendrocyte death results in immune-mediated CNS demyelination.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26277898"> <div itemprop="name">The breast tumor microenvironment alters the phenotype and function of natural killer cells.</div> </a> <div itemprop="about">Cellular & molecular immunology</div> <div itemprop="author">Krneta T,Gillgrass A,Chew M,Ashkar AA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27594448"> <div itemprop="name">Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor.</div> </a> <div itemprop="about">Molecular cell</div> <div itemprop="author">Zhang B,Kwon OJ,Henry G,Malewska A,Wei X,Zhang L,Brinkley W,Zhang Y,Castro PD,Titus M,Chen R,Sayeeduddin M,Raj GV,Mauck R,Roehrborn C,Creighton CJ,Strand DW,Ittmann MM,Xin L</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26779981"> <div itemprop="name">Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.</div> </a> <div itemprop="about">Annals of surgery</div> <div itemprop="author">Loder S,Agarwal S,Sorkin M,Breuler C,Li J,Peterson J,Gardenier J,Hsieh HH,Wang SC,Mehrara BJ,Levi B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26573799"> <div itemprop="name">An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Tavaré R,Escuin-Ordinas H,Mok S,McCracken MN,Zettlitz KA,Salazar FB,Witte ON,Ribas A,Wu AM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate anti-CD8 immuno-PET as a sensitive tool for tracking systemic and tumour-infiltrating CD8+ T cell expression in tumour immunotherapy models.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26699479"> <div itemprop="name">Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Nishio M,Sugimachi K,Goto H,Wang J,Morikawa T,Miyachi Y,Takano Y,Hikasa H,Itoh T,Suzuki SO,Kurihara H,Aishima S,Leask A,Sasaki T,Nakano T,Nishina H,Nishikawa Y,Sekido Y,Nakao K,Shin-Ya K,Mimori K,Suzuki A</div> <div itemprop="description">12-0451 was used in Immunofluorescence to study the molecular mechanisms underpinning the pathology of Mob1a/1b-deficient mice.</div> <div itemprodp="datePublished">Tue Jan 05 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27068890"> <div itemprop="name">Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Agarwal S,Loder SJ,Sorkin M,Li S,Shrestha S,Zhao B,Mishina Y,James AW,Levi B</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27357149"> <div itemprop="name">Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menendez CM,Jinkins JK,Carr DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27385780"> <div itemprop="name">Protein Translation Activity: A New Measure of Host Immune Cell Activation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26756870"> <div itemprop="name">ECM-Dependence of Endothelial Progenitor Cell Features.</div> </a> <div itemprop="about">Journal of cellular biochemistry</div> <div itemprop="author">Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26572749"> <div itemprop="name">Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26854397"> <div itemprop="name">A flow cytometric approach to analyzing mature and progenitor endothelial cells following traumatic brain injury.</div> </a> <div itemprop="about">Journal of neuroscience methods</div> <div itemprop="author">Assis-Nascimento P,Umland O,Cepero ML,Liebl DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28000790"> <div itemprop="name">A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27272654"> <div itemprop="name">Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27538380"> <div itemprop="name">Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Klose R,Krzywinska E,Castells M,Gotthardt D,Putz EM,Kantari-Mimoun C,Chikdene N,Meinecke AK,Schrödter K,Helfrich I,Fandrey J,Sexl V,Stockmann C</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 19 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27659202"> <div itemprop="name">Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Xiong J,Zhou MF,Wang YD,Chen LP,Xu WF,Wang YD,Deng F,Liu SD</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Sep 23 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26809474"> <div itemprop="name">MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.</div> <div itemprodp="datePublished">Tue Jan 26 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27869129"> <div itemprop="name">Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.</div> <div itemprodp="datePublished">Mon Nov 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27335895"> <div itemprop="name">Preparation of Single Cell Suspensions from Mouse Aorta.</div> </a> <div itemprop="about">Bio-protocol</div> <div itemprop="author">Hu D,Yin C,Mohanta SK,Weber C,Habenicht AJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Jun 05 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27158674"> <div itemprop="name">NFAT restricts osteochondroma formation from entheseal progenitors.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Ge X,Tsang K,He L,Garcia RA,Ermann J,Mizoguchi F,Zhang M,Zhou B,Zhou B,Aliprantis AO</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate that nuclear factor of activated T cells c1 and c2 suppress osteochondromagenesis through individual and combinatorial mechanisms in mice.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27057467"> <div itemprop="name">Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27302484"> <div itemprop="name">Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27493002"> <div itemprop="name">LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Shi Y,Wu W,Chai Q,Li Q,Hou Y,Xia H,Ren B,Xu H,Guo X,Jin C,Lv M,Wang Z,Fu YX,Zhu M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 05 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25985364"> <div itemprop="name">KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show how KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26030851"> <div itemprop="name">Host microbiota constantly control maturation and function of microglia in the CNS.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25664855"> <div itemprop="name">Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 02 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25637383"> <div itemprop="name">Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Herbst S,Shah A,Mazon Moya M,Marzola V,Jensen B,Reed A,Birrell MA,Saijo S,Mostowy S,Shaunak S,Armstrong-James D</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25948589"> <div itemprop="name">Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Ruscetti M,Quach B,Dadashian EL,Mulholland DJ,Wu H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25858253"> <div itemprop="name">Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.</div> </a> <div itemprop="about">Cardiovascular research</div> <div itemprop="author">Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26401006"> <div itemprop="name">Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Bardina SV,Michlmayr D,Hoffman KW,Obara CJ,Sum J,Charo IF,Lu W,Pletnev AG,Lim JK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of inflammatory monocyte migration in West Nile Virus encephalitis, showing differential roles of CCL2 and CCL7 in monocytosis and leukocyte migration.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25598345"> <div itemprop="name">Does FACS perturb gene expression?</div> </a> <div itemprop="about">Cytometry. Part A : the journal of the International Society for Analytical Cytology</div> <div itemprop="author">Richardson GM,Lannigan J,Macara IG</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to examine the effects of fluorescence activated cell sorting separation on short-term transcriptional profiles.</div> <div itemprodp="datePublished">Sun Feb 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26257993"> <div itemprop="name">Conditional immortalization of primary adipocyte precursor cells.</div> </a> <div itemprop="about">Adipocyte</div> <div itemprop="author">Church C,Brown M,Rodeheffer MS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 10 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26170908"> <div itemprop="name">Nonadherent culture method downregulates stem cell antigen-1 expression in mouse bone marrow mesenchymal stem cells.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Deng B,Deng W,Xiao P,Zeng K,Zhang S,Zhang H,Deng DY,Yang Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25840412"> <div itemprop="name">High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.</div> </a> <div itemprop="about">Stem cell research</div> <div itemprop="author">Rao TN,Marks-Bluth J,Sullivan J,Gupta MK,Chandrakanthan V,Fitch SR,Ottersbach K,Jang YC,Piao X,Kulkarni RN,Serwold T,Pimanda JE,Wagers AJ</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to indicate that high-level expression of GPR56 by primitive HSPCs is largely dispensable for steady-state and regenerative hematopoiesis.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26107883"> <div itemprop="name">Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 28 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24380384"> <div itemprop="name">Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26387951"> <div itemprop="name">The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25658639"> <div itemprop="name">Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25648335"> <div itemprop="name">TH2 cells and their cytokines regulate formation and function of lymphatic vessels.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Shin K,Kataru RP,Park HJ,Kwon BI,Kim TW,Hong YK,Lee SH</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate an anti-lymphangiogenic function of Th2 cells and their cytokines IL-4 and IL-13, and show that blockade of these cytokines improves lymphatic function in an asthma model.</div> <div itemprodp="datePublished">Wed Feb 04 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26344905"> <div itemprop="name">Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 13 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25538248"> <div itemprop="name">The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Shahi P,Slorach EM,Wang CY,Chou J,Lu A,Ruderisch A,Werb Z</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate the significant role of Zpo2 in mammary gland homeostasis, and that Zpo2 deregulation may promote breast cancer development.</div> <div itemprodp="datePublished">Fri Feb 06 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25693182"> <div itemprop="name">Cardiac telocytes and fibroblasts in primary culture: different morphologies and immunophenotypes.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Bei Y,Zhou Q,Fu S,Lv D,Chen P,Chen Y,Wang F,Xiao J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Nov 11 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26047815"> <div itemprop="name">Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.</div> </a> <div itemprop="about">Cardiovascular diabetology</div> <div itemprop="author">Darrow AL,Shohet RV</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Jun 06 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26617239"> <div itemprop="name">Endothelial Gata5 transcription factor regulates blood pressure.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26531897"> <div itemprop="name">Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study the regulation of Aire expression in medullary thymic epithelial cells.</div> <div itemprodp="datePublished">Wed Nov 04 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25030167"> <div itemprop="name">Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Sandler VM,Lis R,Liu Y,Kedem A,James D,Elemento O,Butler JM,Scandura JM,Rafii S</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 17 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25368192"> <div itemprop="name">Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Amos-Landgraf JM,Heijmans J,Wielenga MC,Dunkin E,Krentz KJ,Clipson L,Ederveen AG,Groothuis PG,Mosselman S,Muncan V,Hommes DW,Shedlovsky A,Dove WF,van den Brink GR</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that indirect tumour-promoting effects of testosterone likely explain the disparity between the sexes in the development of colonic adenomas.</div> <div itemprodp="datePublished">Tue Nov 18 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24624965"> <div itemprop="name">Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells.</div> </a> <div itemprop="about">Journal of biomedical science</div> <div itemprop="author">Cheng CC,Lee YH,Lin SP,Huangfu WC,Liu IH</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to inhibit the enzymatic activity of cell-autonomous HPSE1 in BM-MSCs to clarify the physiological role of HPSE1 in BM-MSCs.</div> <div itemprodp="datePublished">Thu Mar 13 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24733756"> <div itemprop="name">Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">Cekanaviciute E,Fathali N,Doyle KP,Williams AM,Han J,Buckwalter MS</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25210785"> <div itemprop="name">Age-dependent enterocyte invasion and microcolony formation by Salmonella.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Zhang K,Dupont A,Torow N,Gohde F,Leschner S,Lienenklaus S,Weiss S,Brinkmann MM,Kühnel M,Hensel M,Fulde M,Hornef MW</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to provide important insight in the early steps of Salmonella infection in vivo.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24875883"> <div itemprop="name">Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Kasper KJ,Zeppa JJ,Wakabayashi AT,Xu SX,Mazzuca DM,Welch I,Baroja ML,Kotb M,Cairns E,Cleary PP,Haeryfar SM,McCormick JK</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study how secreted superantigens contribute to the fitness and evolution of S. pyogenes.</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25471571"> <div itemprop="name">Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Gruber RC,Ray AK,Johndrow CT,Guzik H,Burek D,de Frutos PG,Shafit-Zagardo B</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to test whether intracerebroventricular delivery of growth arrest-specific protein 6 during EAE in mice improves the clinical course of disease.</div> <div itemprodp="datePublished">Wed Dec 03 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24983456"> <div itemprop="name">Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.</div> </a> <div itemprop="about">Immunology and cell biology</div> <div itemprop="author">Le Blon D,Hoornaert C,Daans J,Santermans E,Hens N,Goossens H,Berneman Z,Ponsaerts P</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to characterise the distribution of microglia and macrophages in the mouse brain following mesenchymal stem cell implantation, showing that resident immune cells surround the graft site while peripheral immune cells invade the graft.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24446236"> <div itemprop="name">Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25451154"> <div itemprop="name">Bone marrow mesenchymal stem cells provide an antibiotic-protective niche for persistent viable Mycobacterium tuberculosis that survive antibiotic treatment.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Beamer G,Major S,Das B,Campos-Neto A</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24662049"> <div itemprop="name">Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Nobuhisa I,Osawa M,Uemura M,Kishikawa Y,Anani M,Harada K,Takagi H,Saito K,Kanai-Azuma M,Kanai Y,Iwama A,Taga T</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate how cells in intra-aortic clusters maintain their HSC phenotype, showing that they are maintained by Sox17.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24852660"> <div itemprop="name">Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells.</div> </a> <div itemprop="about">Experimental hematology</div> <div itemprop="author">Duong KL,Das S,Yu S,Barr JY,Jena S,Kim E,Zavazava N,Colgan JD,Xue HH,Levasseur DN</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24627421"> <div itemprop="name">Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Cho SW,Park JS,Heo HJ,Park SW,Song S,Kim I,Han YM,Yamashita JK,Youm JB,Han J,Koh GY</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show that mPTP inhibition by CsA alters mitochondrial oxidative metabolism and redox signaling.</div> <div itemprodp="datePublished">Thu Mar 13 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24627421"> <div itemprop="name">Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.</div> </a> <div itemprop="about">Journal of the American Heart Association</div> <div itemprop="author">Cho SW,Park JS,Heo HJ,Park SW,Song S,Kim I,Han YM,Yamashita JK,Youm JB,Han J,Koh GY</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to show that mPTP inhibition by CsA alters mitochondrial oxidative metabolism and redox signaling.</div> <div itemprodp="datePublished">Thu Mar 13 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24401681"> <div itemprop="name">A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.</div> </a> <div itemprop="about">Acta neuropathologica communications</div> <div itemprop="author">Yang M,Rainone A,Shi XQ,Fournier S,Zhang J</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 08 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25173390"> <div itemprop="name">Histological characterization and quantification of cellular events following neural and fibroblast(-like) stem cell grafting in healthy and demyelinated CNS tissue.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Praet J,Santermans E,Reekmans K,de Vocht N,Le Blon D,Hoornaert C,Daans J,Goossens H,Berneman Z,Hens N,Van der Linden A,Ponsaerts P</div> <div itemprop="description">12-0451-82 was used in Flow cytometry/Cell sorting to provide protocols to isolate eGFP(+) neural and fibroblast (-like) stem cells from embryonic mouse tissue, determine cell viability, and induce reproducible demyelination in the CNS of mice by means of cuprizone administration.</div> <div itemprodp="datePublished">Fri May 22 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25198549"> <div itemprop="name">Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 28 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24465914"> <div itemprop="name">Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Danzl NM,Jeong S,Choi Y,Alexandropoulos K</div> <div itemprop="description">12-0451 was used in Immunocytochemistry to examine the developmental stages of thymic epithelial cells, identifying novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.</div> <div itemprodp="datePublished">Wed Oct 29 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25445147"> <div itemprop="name">Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Hari A,Zhang Y,Tu Z,Detampel P,Stenner M,Ganguly A,Shi Y</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 02 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24366868"> <div itemprop="name">The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 14 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25313857"> <div itemprop="name">γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Vu DM,Tai A,Tatro JB,Karas RH,Huber BT,Beasley D</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to reveal a pathogenic role of γδT cells in early atherogenesis in ApoE KO mice, by mechanisms likely to involve their IL-17 production and induction of neutrophilia.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24336287"> <div itemprop="name">Distinct fibroblast lineages determine dermal architecture in skin development and repair.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Driskell RR,Lichtenberger BM,Hoste E,Kretzschmar K,Simons BD,Charalambous M,Ferron SR,Herault Y,Pavlovic G,Ferguson-Smith AC,Watt FM</div> <div itemprop="description">12-0451 was used in Immunohistochemistry to explain why wounding is linked to formation of ECM-rich scar tissue that lacks hair follicles.</div> <div itemprodp="datePublished">Thu Dec 12 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23354167"> <div itemprop="name">GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study how the GATA3-miR-29b axis regulates the tumour microenvironment, and inhibits metastasis to open up possibilities for therapeutic intervention in breast cancer.</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23867620"> <div itemprop="name">Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Bonito AJ,Aloman C,Fiel MI,Danzl NM,Cha S,Weinstein EG,Jeong S,Choi Y,Walsh MC,Alexandropoulos K</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the role of TRAF6 and medullary thymic epithelial cells (mETCs) in autoimmunity, showing that mETC depletion leads to autoimmune hepatitis.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23776077"> <div itemprop="name">PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Pinho S,Lacombe J,Hanoun M,Mizoguchi T,Bruns I,Kunisaki Y,Frenette PS</div> <div itemprop="description">12-0451 was used in Immunofluorescence to evaluate putative cell surface mesenchymal stem cell markers to identify Nestin+ cells in the mouse and human bone marrow.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23180724"> <div itemprop="name">Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.</div> </a> <div itemprop="about">Cardiovascular research</div> <div itemprop="author">Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study exacerbation of atherogenesis with genetic deletion of chemokine receptor Ccr7 in ApoE-deficient mice.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23812634"> <div itemprop="name">Wt1-expressing progenitors contribute to multiple tissues in the developing lung.</div> </a> <div itemprop="about">American journal of physiology. Lung cellular and molecular physiology</div> <div itemprop="author">Cano E,Carmona R,Muñoz-Chápuli R</div> <div itemprop="description">12-0451 was used in Immunofluorescence to report a novel role for embryonic mesothelium-derived cells in lung morphogenesis.</div> <div itemprodp="datePublished">Thu Aug 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23232367"> <div itemprop="name">Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage.</div> </a> <div itemprop="about">Transplantation</div> <div itemprop="author">Shimamura M,Seleme MC,Guo L,Saunders U,Schoeb TR,George JF,Britt WJ</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to examine the lasting effect of Ganciclovir treatment on renal allografts after the discontinuation of prophylaxis.</div> <div itemprodp="datePublished">Tue Jan 15 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23804447"> <div itemprop="name">Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.</div> </a> <div itemprop="about">American journal of physiology. Renal physiology</div> <div itemprop="author">Li S,Mariappan N,Megyesi J,Shank B,Kannan K,Theus S,Price PM,Duffield JS,Portilla D</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study how proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23520544"> <div itemprop="name">Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">El-Zaatari M,Kao JY,Tessier A,Bai L,Hayes MM,Fontaine C,Eaton KA,Merchant JL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 10 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23520544"> <div itemprop="name">Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">El-Zaatari M,Kao JY,Tessier A,Bai L,Hayes MM,Fontaine C,Eaton KA,Merchant JL</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 10 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22722868"> <div itemprop="name">mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Yilmaz ÖH,Katajisto P,Lamming DW,Gültekin Y,Bauer-Rowe KE,Sengupta S,Birsoy K,Dursun A,Yilmaz VO,Selig M,Nielsen GP,Mino-Kenudson M,Zukerberg LR,Bhan AK,Deshpande V,Sabatini DM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to explore how Paneth cells augment stem-cell function in response to calorie restriction.</div> <div itemprodp="datePublished">Thu Jun 28 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23159881"> <div itemprop="name">Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.</div> </a> <div itemprop="about">Nature biotechnology</div> <div itemprop="author">Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22340596"> <div itemprop="name">Tumorigenic cells are common in mouse MPNSTs but their frequency depends upon tumor genotype and assay conditions.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Buchstaller J,McKeever PE,Morrison SJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 14 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22628281"> <div itemprop="name">Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22686371"> <div itemprop="name">A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.</div> </a> <div itemprop="about">Biochemistry</div> <div itemprop="author">Rajasekaran D,Keeler C,Syed MA,Jones MC,Harrison JK,Wu D,Bhandari V,Hodsdon ME,Lolis EJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 17 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22472278"> <div itemprop="name">Cell type-associated differences in migration, survival, and immunogenicity following grafting in CNS tissue.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Praet J,Reekmans K,Lin D,De Vocht N,Bergwerf I,Tambuyzer B,Daans J,Hens N,Goossens H,Pauwels P,Berneman Z,Van der Linden A,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22472278"> <div itemprop="name">Cell type-associated differences in migration, survival, and immunogenicity following grafting in CNS tissue.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Praet J,Reekmans K,Lin D,De Vocht N,Bergwerf I,Tambuyzer B,Daans J,Hens N,Goossens H,Pauwels P,Berneman Z,Van der Linden A,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22577135"> <div itemprop="name">Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Ryu MJ,Liu Y,Zhong X,Du J,Peterson N,Kong G,Li H,Wang J,Salamat S,Chang Q,Zhang J</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to determine how Ras signalling in neurones promotes gliosis and astrocytoma formation in a cell nonautonomous manner.</div> <div itemprodp="datePublished">Fri Jun 29 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21393582"> <div itemprop="name">Stromal vascular fraction from adipose tissue forms profound vascular network through the dynamic reassembly of blood endothelial cells.</div> </a> <div itemprop="about">Arteriosclerosis, thrombosis, and vascular biology</div> <div itemprop="author">Koh YJ,Koh BI,Kim H,Joo HJ,Jin HK,Jeon J,Choi C,Lee DH,Chung JH,Cho CH,Park WS,Ryu JK,Suh JK,Koh GY</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to demonstrate that direct implantation of stromal vascular fraction from donor adipose tissue can produce a vascular network through blood endothelial cells at the site of implantation.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21989919"> <div itemprop="name">ER71 directs mesodermal fate decisions during embryogenesis.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22031549"> <div itemprop="name">Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Collins CA,Kretzschmar K,Watt FM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to display the plasticity of the characteristics of the dermis in response to cues from the epidermis.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21421850"> <div itemprop="name">Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21296809"> <div itemprop="name">Effect of topical azithromycin on corneal innate immune responses.</div> </a> <div itemprop="about">Investigative ophthalmology & visual science</div> <div itemprop="author">Sadrai Z,Hajrasouliha AR,Chauhan S,Saban DR,Dastjerdi MH,Dana R</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 19 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21925233"> <div itemprop="name">A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.</div> </a> <div itemprop="about">Toxicology</div> <div itemprop="author">Mustafa A,Holladay SD,Witonsky S,Sponenberg DP,Karpuzoglu E,Gogal RM</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the effect of prenatal TCDD on the postnatal autoimmune status of C57BL/6 mice.</div> <div itemprodp="datePublished">Sun Dec 18 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21703864"> <div itemprop="name">Myeloid cells migrate in response to IL-24.</div> </a> <div itemprop="about">Cytokine</div> <div itemprop="author">Buzas K,Oppenheim JJ,Zack Howard OM</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21907166"> <div itemprop="name">Fetal muscle contains different CD34+ cell subsets that distinctly differentiate into adipogenic, angiogenic and myogenic lineages.</div> </a> <div itemprop="about">Stem cell research</div> <div itemprop="author">Dupas T,Rouaud T,Rouger K,Lieubeau B,Cario-Toumaniantz C,Fontaine-Pérus J,Gardahaut MF,Auda-Boucher G</div> <div itemprop="description">12-0451 was used in Magnetic cell separation to purify different subsets of CD34(+) cells from fetal mice and analyse their developmental potential in vitro and in vivo.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21092405"> <div itemprop="name">Clinical potential of intravenous neural stem cell delivery for treatment of neuroinflammatory disease in mice?</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Reekmans KP,Praet J,De Vocht N,Tambuyzer BR,Bergwerf I,Daans J,Baekelandt V,Vanhoutte G,Goossens H,Jorens PG,Ysebaert DK,Chatterjee S,Pauwels P,Van Marck E,Berneman ZN,Van der Linden A,Ponsaerts P</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 09 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19497969"> <div itemprop="name">Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19451396"> <div itemprop="name">Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18634851"> <div itemprop="name">Deletion of both ICAM-1 and C3 enhances severity of experimental autoimmune encephalomyelitis compared to C3-deficient mice.</div> </a> <div itemprop="about">Neuroscience letters</div> <div itemprop="author">Smith SS,Ludwig M,Wohler JE,Bullard DC,Szalai AJ,Barnum SR</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to examine experimental autoimmune encephalitis in ICAM-1 x C3 double knockout mice.</div> <div itemprodp="datePublished">Fri Sep 12 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17661344"> <div itemprop="name">Optimized isolation enables ex vivo analysis of microglia from various central nervous system regions.</div> </a> <div itemprop="about">Glia</div> <div itemprop="author">de Haas AH,Boddeke HW,Brouwer N,Biber K</div> <div itemprop="description">Published figure using CD45 monoclonal antibody (Product # 12-0451-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Oct 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16597594"> <div itemprop="name">Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Sakamoto H,Dai G,Tsujino K,Hashimoto K,Huang X,Fujimoto T,Mucenski M,Frampton J,Ogawa M</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to investigate the functional role of c-Myb in hematopoietic cell development from endothelial cells, showing that proper levels of c-Myb are discretely defined at distinct steps of development.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15833919"> <div itemprop="name">Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.</div> </a> <div itemprop="about">Genes & development</div> <div itemprop="author">Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV</div> <div itemprop="description">12-0451 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2005</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> CD45; L-CA; Leukocyte common antigen; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Receptor-type tyrosine-protein phosphatase C; T200; T220 and B220 </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; Ptprc; T200 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P06800" target="_blank">(Mouse) P06800</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=19264" target="_blank">(Mouse) 19264</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/phosphoprotein phosphatase activity"> phosphoprotein phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein tyrosine phosphatase activity"> protein tyrosine phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/heparin binding"> heparin binding </a> <a class="icon" href="/antibody/primary/panther/hydrolase activity"> hydrolase activity </a> <a class="icon" href="/antibody/primary/panther/phosphatase activity"> phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/heparan sulfate proteoglycan binding"> heparan sulfate proteoglycan binding </a> <a class="icon" href="/antibody/primary/panther/protein phosphatase"> protein phosphatase </a> <a class="icon" href="/antibody/primary/panther/protein modifying enzyme"> protein modifying enzyme </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/activation of MAPK activity"> activation of MAPK activity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of T cell mediated cytotoxicity"> negative regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated cytotoxicity"> positive regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cytokine-mediated signaling pathway"> negative regulation of cytokine-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/hematopoietic progenitor cell differentiation"> hematopoietic progenitor cell differentiation </a> <a class="icon" href="/antibody/primary/panther/immunoglobulin biosynthetic process"> immunoglobulin biosynthetic process </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated immunity"> positive regulation of T cell mediated immunity </a> <a class="icon" href="/antibody/primary/panther/regulation of humoral immune response mediated by circulating immunoglobulin"> regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/positive regulation of humoral immune response mediated by circulating immunoglobulin"> positive regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein kinase activity"> negative regulation of protein kinase activity </a> <a class="icon" href="/antibody/primary/panther/protein dephosphorylation"> protein dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cell adhesion involved in substrate-bound cell migration"> negative regulation of cell adhesion involved in substrate-bound cell migration </a> <a class="icon" href="/antibody/primary/panther/leukocyte cell-cell adhesion"> leukocyte cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/response to gamma radiation"> response to gamma radiation </a> <a class="icon" href="/antibody/primary/panther/dephosphorylation"> dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/B cell differentiation"> B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/T cell differentiation"> T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of B cell proliferation"> positive regulation of B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein autophosphorylation"> negative regulation of protein autophosphorylation </a> <a class="icon" href="/antibody/primary/panther/heterotypic cell-cell adhesion"> heterotypic cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/peptidyl-tyrosine dephosphorylation"> peptidyl-tyrosine dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/T cell proliferation"> T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/B cell proliferation"> B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell proliferation"> positive regulation of T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of MAPK cascade"> positive regulation of MAPK cascade </a> <a class="icon" href="/antibody/primary/panther/cell cycle phase transition"> cell cycle phase transition </a> <a class="icon" href="/antibody/primary/panther/positive thymic T cell selection"> positive thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/negative thymic T cell selection"> negative thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell differentiation"> regulation of B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell differentiation"> positive regulation of T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of gamma-delta T cell differentiation"> positive regulation of gamma-delta T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of alpha-beta T cell proliferation"> positive regulation of alpha-beta T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of isotype switching to IgG isotypes"> positive regulation of isotype switching to IgG isotypes </a> <a class="icon" href="/antibody/primary/panther/bone marrow development"> bone marrow development </a> <a class="icon" href="/antibody/primary/panther/stem cell development"> stem cell development </a> <a class="icon" href="/antibody/primary/panther/negative regulation of peptidyl-tyrosine phosphorylation"> negative regulation of peptidyl-tyrosine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/T cell receptor signaling pathway"> T cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/B cell receptor signaling pathway"> B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell receptor signaling pathway"> regulation of B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of antigen receptor-mediated signaling pathway"> positive regulation of antigen receptor-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/release of sequestered calcium ion into cytosol"> release of sequestered calcium ion into cytosol </a> <a class="icon" href="/antibody/primary/panther/defense response to virus"> defense response to virus </a> <a class="icon" href="/antibody/primary/panther/regulation of cell cycle"> regulation of cell cycle </a> <a class="icon" href="/antibody/primary/panther/positive regulation of hematopoietic stem cell migration"> positive regulation of hematopoietic stem cell migration </a> <a class="icon" href="/antibody/primary/panther/positive regulation of stem cell proliferation"> positive regulation of stem cell proliferation </a> <a class="icon" href="/antibody/primary/panther/regulation of extrinsic apoptotic signaling pathway"> regulation of extrinsic apoptotic signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of extrinsic apoptotic signaling pathway"> positive regulation of extrinsic apoptotic signaling pathway </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/angular108-document-scripts.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp-combined-scripts.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/combined-vendor.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/core/dist/angular/gallery-module/gallery-module.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/angular/dist/pdp/common.pdp.dist.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript" src="/order/genome-database/assets/js/angular/dist/pdp/antibody.pdp.dist.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-cmrc-card-antibody.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-hero.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script defer type="text/javascript" src="/order/genome-database/assets/js/shared-module/dist/pdp/template-cache-reference-section.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadEnd'); $m.addPerformanceMeasure('abPDPScripts:loadTime' , 'abPDPScripts:loadBegin', 'abPDPScripts:loadEnd'); </script> </div> <script> if (typeof window.$mangular === 'undefined' || !window.$mangular) { window.$mangular = {}; } window.$mangular.referenceCount = 313; window.$mangular.publishedFiguresCount = 97; window.$mangular.productId = '12-0451-82'; window.$mangular.citationJson = {"citationApplications":[{"applicationAbbreviation":"IHC","citations":[{"title":"A patient derived xenograft model of cervical cancer and cervical dysplasia.","summary":"12-0451 was used in Immunohistochemistry to develop a patient derived xenograft model of cervical cancer and cervical dysplasia using the subrenal capsule.","authors":"Larmour LI,Cousins FL,Teague JA,Deane JA,Jobling TW,Gargett CE","literatureId":"30365542","journal":"PloS one","volume":"13","publishedDate":"Mar 29, 2019, 4:00:00 AM","url":"http://dx.doi.org/10.1371/journal.pone.0206539","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"PLoS One","sortOrder":179,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:100"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~1:100":"1:100"}},{"title":"The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.","summary":"12-0451 was used in Immunohistochemistry-immunofluorescence to observe the role played by the Hippo pathway in suppressing anti-tumour immunity.","authors":"Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL","literatureId":"27912060","journal":"Cell","volume":"167","pageNumber":"1525","publishedDate":"Dec 1, 2016, 5:00:00 AM","url":"http://dx.doi.org/10.1016/j.cell.2016.11.005","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Cell","sortOrder":216,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"Not Cited"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~Not Cited":""}},{"title":"Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles.","summary":"12-0451-82 was used in Immunohistochemistry to report incorporation of sunitinib, a tyrosine kinase inhibitor that blocks VEGF receptors, into a non-inflammatory biodegradable polymer to generate sunitinib microparticles specially formulated to self-aggregate into a depot.","authors":"Tsujinaka H,Fu J,Shen J,Yu Y,Hafiz Z,Kays J,McKenzie D,Cardona D,Culp D,Peterson W,Gilger BC,Crean CS,Zhang JZ,Kanan Y,Yu W,Cleland JL,Yang M,Hanes J,Campochiaro PA","literatureId":"32019921","journal":"Nature communications","volume":"11","publishedDate":"Feb 4, 2020, 5:00:00 AM","url":"http://dx.doi.org/10.1038/s41467-020-14340-x","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Nat Commun","sortOrder":120,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"Not Cited"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~Not Cited":""}}],"citationsCount":4,"speciesList":["Mouse"],"journals":["PLoS One","Nat Commun","Oncogene","Cell"],"speciesMap":{"Mouse":4},"journalsMap":{"PLoS One":1,"Nat Commun":1,"Oncogene":1,"Cell":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (PFA)","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["J Exp Med"],"speciesMap":{"Mouse":1},"journalsMap":{"J Exp Med":1},"sortedMap":{}},{"applicationAbbreviation":"IHC (F)","citations":[],"citationsCount":3,"speciesList":["Mouse"],"journals":["Nat Commun","Sci Rep","Am J Physiol Lung Cell Mol Physiol"],"speciesMap":{"Mouse":3},"journalsMap":{"Nat Commun":1,"Sci Rep":1,"Am J Physiol Lung Cell Mol Physiol":1},"sortedMap":{}},{"applicationAbbreviation":"ICC/IF","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Proc Natl Acad Sci U S A"],"speciesMap":{"Mouse":1},"journalsMap":{"Proc Natl Acad Sci U S A":1},"sortedMap":{}},{"applicationAbbreviation":"Flow","citations":[],"citationsCount":301,"speciesList":["Human","Mouse"],"journals":["NPJ Vaccines","Brain","Mol Med Rep","Cell Mol Biol Lett","Nat Commun","Methods Mol Biol","Int J Med Sci","Invest Ophthalmol Vis Sci","Front Cardiovasc Med","Blood","J Cell Mol Med","Stem Cells","Nat Neurosci","Toxicology","Nat Med","Arterioscler Thromb Vasc Biol","J Autoimmun","Development","Nat Cell Biol","Am J Pathol","J Am Heart Assoc","Stem Cell Res","eNeuro","PLoS One","J Cell Biochem","Dev Cell","EMBO Rep","J Neurosci Methods","Skelet Muscle","J Am Soc Nephrol","J Extracell Vesicles","J Neuroinflammation","Int J Biol Sci","Nat Struct Mol Biol","J Cereb Blood Flow Metab","Bioact Mater","Elife","J Immunol","Mol Cell","NPJ Regen Med","Mol Metab","Muscle Nerve","Nat Biotechnol","Hum Mol Genet","Am J Physiol Lung Cell Mol Physiol","Anticancer Drugs","J Neurosci","J Leukoc Biol","JCI Insight","Oncoimmunology","Aging Cell","J Invest Dermatol","Nature","J Nanobiotechnology","Stem Cell Reports","Front Cell Infect Microbiol","Cardiovasc Diabetol","Cell Transplant","Cancer Cell","Br J Pharmacol","Cell Physiol Biochem","Immun Inflamm Dis","Adv Sci (Weinh)","J Clin Invest","Exp Hematol","Cell Stem Cell","J Cell Physiol","Acta Neuropathol Commun","Proc Natl Acad Sci U S A","Commun Biol","J Bone Miner Res","Breast Cancer Res","Sci Adv","J Cell Commun Signal","Immunol Cell Biol","Front Cell Dev Biol","Biochemistry","Mol Cell Biol","Immunity","Front Mol Neurosci","Ann Surg","Neurosci Lett","Open Life Sci","Cell Biosci","Cell","Cancer Res","Kidney360","Front Nutr","Cancers (Basel)","Cytokine","Acta Pharm Sin B","NPJ Aging Mech Dis","STAR Protoc","Cell Host Microbe","Stem Cell Res Ther","Ther Adv Chronic Dis","Chin Med J (Engl)","Sci Rep","Bio Protoc","Cell Death Differ","Adipocyte","EMBO Mol Med","Cardiovasc Res","EMBO J","Cell Mol Immunol","J Allergy Clin Immunol","Int J Mol Sci","Nat Immunol","BMC Biol","J Exp Med","Transplantation","Cell Rep","Exp Ther Med","Genes Dev","Cell Death Dis","Cell Mol Life Sci","J Virol","J Neuroimmunol","J Immunother Cancer","J Biomed Sci","Nutrients","Am J Physiol Renal Physiol","Front Immunol","Front Pharmacol","Theranostics","Cells","Pain Res Manag","Basic Res Cardiol","Cell Mol Gastroenterol Hepatol","Life Sci Alliance","PLoS Pathog","J Biol Chem","Glia","Prostate","Cytometry A"],"speciesMap":{"Human":8,"Mouse":130},"journalsMap":{"NPJ Vaccines":1,"Brain":1,"Mol Med Rep":4,"Cell Mol Biol Lett":2,"Nat Commun":27,"Methods Mol Biol":1,"Int J Med Sci":1,"Invest Ophthalmol Vis Sci":1,"Front Cardiovasc Med":1,"Blood":1,"J Cell Mol Med":1,"Stem Cells":3,"Nat Neurosci":2,"Toxicology":1,"Nat Med":1,"Arterioscler Thromb Vasc Biol":1,"J Autoimmun":1,"Development":3,"Nat Cell Biol":4,"Am J Pathol":1,"J Am Heart Assoc":1,"Stem Cell Res":1,"eNeuro":1,"PLoS One":9,"J Cell Biochem":2,"Dev Cell":1,"EMBO Rep":2,"J Neurosci Methods":1,"Skelet Muscle":1,"J Am Soc Nephrol":2,"J Extracell Vesicles":1,"J Neuroinflammation":6,"Int J Biol Sci":1,"Nat Struct Mol Biol":1,"J Cereb Blood Flow Metab":2,"Bioact Mater":1,"Elife":9,"J Immunol":4,"Mol Cell":1,"NPJ Regen Med":1,"Mol Metab":1,"Muscle Nerve":1,"Nat Biotechnol":1,"Hum Mol Genet":1,"Am J Physiol Lung Cell Mol Physiol":1,"Anticancer Drugs":1,"J Neurosci":1,"J Leukoc Biol":1,"JCI Insight":11,"Oncoimmunology":2,"Aging Cell":1,"J Invest Dermatol":1,"Nature":6,"J Nanobiotechnology":3,"Stem Cell Reports":2,"Front Cell Infect Microbiol":1,"Cardiovasc Diabetol":1,"Cell Transplant":3,"Cancer Cell":2,"Br J Pharmacol":1,"Cell Physiol Biochem":1,"Immun Inflamm Dis":1,"Adv Sci (Weinh)":1,"J Clin Invest":6,"Exp Hematol":1,"Cell Stem Cell":4,"J Cell Physiol":2,"Acta Neuropathol Commun":1,"Proc Natl Acad Sci U S A":3,"Commun Biol":1,"J Bone Miner Res":1,"Breast Cancer Res":1,"Sci Adv":1,"J Cell Commun Signal":1,"Immunol Cell Biol":2,"Front Cell Dev Biol":1,"Biochemistry":1,"Mol Cell Biol":1,"Immunity":6,"Front Mol Neurosci":1,"Ann Surg":1,"Neurosci Lett":1,"Open Life Sci":1,"Cell Biosci":1,"Cell":5,"Cancer Res":3,"Kidney360":1,"Front Nutr":1,"Cancers (Basel)":3,"Cytokine":1,"Acta Pharm Sin B":2,"NPJ Aging Mech Dis":1,"STAR Protoc":2,"Cell Host Microbe":1,"Stem Cell Res Ther":1,"Ther Adv Chronic Dis":1,"Chin Med J (Engl)":1,"Sci Rep":9,"Bio Protoc":1,"Cell Death Differ":3,"Adipocyte":2,"EMBO Mol Med":3,"Cardiovasc Res":2,"EMBO J":1,"Cell Mol Immunol":1,"J Allergy Clin Immunol":1,"Int J Mol Sci":5,"Nat Immunol":1,"BMC Biol":1,"J Exp Med":2,"Transplantation":1,"Cell Rep":7,"Exp Ther Med":2,"Genes Dev":1,"Cell Death Dis":4,"Cell Mol Life Sci":1,"J Virol":1,"J Neuroimmunol":1,"J Immunother Cancer":3,"J Biomed Sci":1,"Nutrients":1,"Am J Physiol Renal Physiol":1,"Front Immunol":9,"Front Pharmacol":1,"Theranostics":1,"Cells":1,"Pain Res Manag":1,"Basic Res Cardiol":1,"Cell Mol Gastroenterol Hepatol":2,"Life Sci Alliance":1,"PLoS Pathog":4,"J Biol Chem":4,"Glia":6,"Prostate":1,"Cytometry A":1},"sortedMap":{}},{"applicationAbbreviation":"AP","citations":[],"citationsCount":1,"speciesList":["Mouse"],"journals":["Cell Rep"],"speciesMap":{"Mouse":1},"journalsMap":{"Cell Rep":1},"sortedMap":{}},{"applicationAbbreviation":"Misc","citations":[],"citationsCount":2,"speciesList":["Mouse"],"journals":["Stem Cell Res","Nat Med"],"speciesMap":{"Mouse":2},"journalsMap":{"Stem Cell Res":1,"Nat Med":1},"sortedMap":{}}]}; window.$mangular.tfRelatedProductsModuleURL = '/api/magellan/related-products-ui/widget/v2/'; THERMO_FISHER.pdp.productOrderComponent = {}; THERMO_FISHER.pdp.productOrderComponent.productDetailViewModel = {"sku":"12-0451-82","productSize":"100 µg","webId":"12-0451-82","packageDetails":[{"sku":"12-0451-81","size":"50 µg","onlinePriceApplicable":false,"entitled":true,"priced":false,"leadTimeEU":"1 business day","webId":"12-0451-81","searchStatus":true,"longTermUnavailable":false,"parentSku":false,"orderable":false,"discontinued":false,"thirdPartyProduct":false,"leadTimeCN":"1-2 weeks"},{"sku":"12-0451-82","size":"100 µg","onlinePriceApplicable":false,"entitled":true,"priced":false,"leadTimeEU":"1 business day","webId":"12-0451-82","searchStatus":true,"longTermUnavailable":false,"parentSku":true,"orderable":false,"discontinued":false,"thirdPartyProduct":false,"leadTimeCN":"1-2 weeks"},{"sku":"12-0451-83","size":"200 µg","onlinePriceApplicable":false,"entitled":true,"priced":false,"leadTimeEU":"1 business day","webId":"12-0451-83","searchStatus":true,"longTermUnavailable":false,"parentSku":false,"orderable":false,"discontinued":false,"thirdPartyProduct":false,"leadTimeCN":"1-2 weeks"}],"orderable":false,"longTermUnavailable":false,"discontinued":false}; THERMO_FISHER.pdp.productOrderComponent.productType = 'antibody'; THERMO_FISHER.pdp.productOrderComponent.productSubType = 'antibody_primary'; THERMO_FISHER.pdp.productOrderComponent.brand = 'Invitrogen'; THERMO_FISHER.pdp.productOrderComponent.userKey = "NONE"; THERMO_FISHER.pdp.productOrderComponent.productDesc = 'Description: The 30-F11 monoclonal antibody reacts with all isoforms of mouse CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.<br /><br />Applications Reported: The 30-F11 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: This 30-F11 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.'; THERMO_FISHER.pdp.productOrderComponent.imageForSchemaMarkup = 'https://www.thermofisher.com/antibody/images/650/12-0451-cd45-flow-cytometry-26jan2018lsrflz-30-f11-pe_20200714144611.jpg?time=20240507?time=20240507'; THERMO_FISHER.pdp.productOrderComponent.productSpecificationTableData = '[{"name":"Species Reactivity","value":"Mouse "},{"name":"Published species","value":"Human ,Mouse "},{"name":"Host / Isotype","value":"Rat/ IgG2b, kappa"},{"name":"Recommended Isotype Control","value":"Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™"},{"name":"Class","value":"Monoclonal"},{"name":"Type","value":"Antibody"},{"name":"Clone","value":"30-F11"},{"name":"Conjugate","value":"PE "},{"name":"Excitation/Emission Max","value":"565/576 nm "},{"name":"Form","value":"Liquid"},{"name":"Concentration","value":"0.2 mg/mL"},{"name":"Purification","value":"Affinity chromatography"},{"name":"Storage buffer","value":"PBS, pH 7.2"},{"name":"Contains","value":"0.09% sodium azide"},{"name":"Storage conditions","value":"4° C, store in dark, DO NOT FREEZE!"},{"name":"Shipping conditions","value":"Ambient (domestic); Wet ice (international)"},{"name":"RRID","value":"AB_465668"}]'; $m.userKey = "NONE"; angular.element(document).ready(function() { angular.bootstrap('#pdp-components', ['antibodyPdpModule']); }); THERMO_FISHER.pdp.sharedListComponent = THERMO_FISHER.pdp.sharedListComponent || {}; THERMO_FISHER.pdp.sharedListComponent.sharedList = null; </script> </div> <div class="documents"> <div class="documents-cntr" id="documents-container"> <div class="loading-wheel-lg hidden" id="documentLoadingWheel"></div> <div id="documentsUIRoot1"></div> </div>  <script defer type="text/javascript" src="/store/v2/documents/static/conditionalLoadAssets.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script>  <script> window.THERMO_FISHER = window.THERMO_FISHER || {}; THERMO_FISHER.pdp = THERMO_FISHER.pdp || {}; THERMO_FISHER.pdp.documents = THERMO_FISHER.pdp.documents || {}; THERMO_FISHER.pdp.documents.selectedProductId = '12-0451-82'; THERMO_FISHER.pdp.documents.documentsFetched = false; THERMO_FISHER.pdp.documents.reqParam = { containerId: 'documentsUIRoot1', skus: [THERMO_FISHER.pdp.documents.selectedProductId], showCertificates: true, showSds: true, showOthers: true, expanded: 'true' }; THERMO_FISHER.pdp.documents.docSectionEle = document.getElementById("rootPdpDocLoader"); var documentLoadingWheel = document.getElementById("documentLoadingWheel"); THERMO_FISHER.pdp.documents.fetchDocuments = function() { setTimeout(function() { var docUi = document.getElementsByClassName("product-documents-ui"); if (typeof documentsConfiguration != "undefined" && typeof docUi != "undefined") { documentsConfiguration([THERMO_FISHER.pdp.documents.reqParam]); THERMO_FISHER.pdp.documents.documentsFetched = true; documentLoadingWheel.classList.add("hidden"); } else { console.log("loadDocuments: window.documentsConfiguration is UNDEFINED"); } }, 3000); }; if(THERMO_FISHER.pdp.documents.docSectionEle){ THERMO_FISHER.pdp.documents.intersectionObserver = new IntersectionObserver(function(elements) { elements.forEach(function(entry) { if(!THERMO_FISHER.pdp.documents.documentsFetched && entry.intersectionRatio >= 0.07){ documentLoadingWheel.classList.remove("hidden"); THERMO_FISHER.pdp.documents.fetchDocuments(); } }); }); THERMO_FISHER.pdp.documents.intersectionObserver.observe(THERMO_FISHER.pdp.documents.docSectionEle); } </script> </div> <div class="two-up-module-container">   <div class="two-up-row" id="bottom-cta-banner" style="display: block;"> <div class="two-up-row-divider container"> <div class="row"> <div class="span5 medium-span-5 small-span-12"> <img src="https://www.thermofisher.com/content/dam/LifeTech/global/life-sciences/Antibodies/images/guarantee.png" class="column-image" alt="guarantee_icon" loading="lazy"> <h2 class="two-up-header">Performance Guarantee</h2> <p class="two-up-paragraph">If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*</p> <a href="https://www.thermofisher.com/us/en/home/life-science/antibodies/antibody-performance-guarantee.html" class="btn two-up-btn performance-guarantee-button">Learn more</a> </div> <div class="span5 medium-span-5 small-span-12 right-content"> <img src="https://www.thermofisher.com/content/dam/LifeTech/global/life-sciences/Antibodies/images/help.png" class="column-image" alt="help_icon" loading="lazy"> <h2 class="two-up-header">We're here to help</h2> <p class="two-up-paragraph">Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.</p> <a id="tech_link" href="https://www.thermofisher.com/us/en/home/technical-resources/contact-us.12-0451-82.html?supportType=TS" class="btn two-up-btn" >Contact tech support</a> </div> </div> </div> </div> </div> </div> </div> <script> // load global functions callIfOrWhenWindowLoaded(window.THERMO_FISHER.scroll.init()); </script> <link rel="stylesheet" type="text/css" href="/order/genome-database/assets/core/dist/fonts/thermofisher.icons.css?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"/> </div>  </div> </div> <div class="footer group"> <style> .no-logo{ min-height: 80px; } </style> <footer id="tf-global-footer" style=""> <div class="globalFooter" data-orig="tfpt-header-footer" data-app-env="prod" data-site="tf" data-hostname="www.thermofisher.com" data-x-host="www.thermofisher.com" data-env="prod" data-hash="468bd07150dbbf" data-version="4.03.29" data-analytics-section="header" data-aem-syndication-info="(sg:en-sg:anonymous:https-tf)" data-aem-syndication-timestamp="globalHeader: Wed, 27 Nov 2024 17:21:20 GMT" data-optional-selectors="inlineCss,globalRoute">           <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalFooter:renderBegin"); </script>  <style data-inline-file-name='footer.min.css' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/css/dist/footer.min.css */ @charset "UTF-8";@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:lighter;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-35Thin.woff2) format("woff2");font-weight:100;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:200;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-45Light.woff2) format("woff2");font-weight:300;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-55Roman.woff2) format("woff2");font-weight:400;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-56Italic.woff2) format("woff2");font-weight:400;font-style:italic;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:500;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-65Medium.woff2) format("woff2");font-weight:600;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:800;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:900;font-style:normal;font-display:swap}@font-face{font-family:HelveticaNeue;src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix);src:url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.eot?#iefix) format("eot"),url(/designsystem-cdn/fonts/HelveticaNeueLTW01-75Bold.woff2) format("woff2");font-weight:700;font-style:normal;font-display:swap}footer,header{font-family:HelveticaNeue,sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;max-width:100%;scroll-behavior:smooth;color:#1b1b1d;margin:0}footer *,header *{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :after,footer :before,header :after,header :before{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}footer :focus-visible,header :focus-visible{outline:2px solid #802eff}footer input:focus-visible,header input:focus-visible{outline:0}footer .bold-label,header .bold-label{font-weight:700}footer .h1,footer .h2,footer .h3,footer .h4,footer .h5,footer .h6,footer body,footer h1,footer h2,footer h3,footer h4,footer h5,footer h6,header .h1,header .h2,header .h3,header .h4,header .h5,header .h6,header body,header h1,header h2,header h3,header h4,header h5,header h6{color:#222}footer .text-light,footer .text-light .display-1,footer .text-light .display-2,footer .text-light .display-3,footer .text-light .display-4,footer .text-light .h1,footer .text-light .h2,footer .text-light .h3,footer .text-light .h4,footer .text-light .h5,footer .text-light .h6,footer .text-light body,footer .text-light h1,footer .text-light h2,footer .text-light h3,footer .text-light h4,footer .text-light h5,footer .text-light h6,header .text-light,header .text-light .display-1,header .text-light .display-2,header .text-light .display-3,header .text-light .display-4,header .text-light .h1,header .text-light .h2,header .text-light .h3,header .text-light .h4,header .text-light .h5,header .text-light .h6,header .text-light body,header .text-light h1,header .text-light h2,header .text-light h3,header .text-light h4,header .text-light h5,header .text-light h6{color:#fff}footer body,header body{margin:0;font-size:16px;line-height:26px}footer p,header p{margin-top:0;margin-bottom:0;font-size:16px;line-height:26px}footer .p-grey,header .p-grey{color:#54545c}footer .text-center,header .text-center{text-align:center}footer .alt,header .alt{font-size:16px;line-height:26px}footer .text-size-14,header .text-size-14{font-size:14px;line-height:22px}footer a,header a{text-decoration:none;color:#1b1b1d}footer a:hover,header a:hover{text-decoration:none;color:#1b1b1d}footer a:visited,header a:visited{text-decoration:none;color:#1b1b1d}footer .disabled,header .disabled{color:#a2a2a2}footer .label-medium,header .label-medium{color:#222;font-size:16px;line-height:26px;font-weight:400}footer .label-bold,header .label-bold{color:#222;font-size:16px;line-height:26px;font-weight:bolder}footer .hint,header .hint{font-size:14px;line-height:30.727268px}footer .blockquote,header .blockquote{color:#222;font-size:20.571424px;line-height:33.090902px;margin-bottom:0}footer .alt-color,header .alt-color{color:#54545c}footer .success,header .success{color:#3bad2f}footer .warning,header .warning{color:#ed7700}footer .error,header .error{color:#e71316}footer .thin,header .thin{font-weight:lighter}footer .light,header .light{font-weight:300}footer .italic,header .italic{font-style:italic}footer .medium,header .medium{font-weight:700}footer .bold,header .bold{font-weight:bolder}footer .h1,footer .h2,footer .h3,footer .h5,footer h1,footer h2,footer h3,footer h5,header .h1,header .h2,header .h3,header .h5,header h1,header h2,header h3,header h5{font-weight:400;margin:0;padding-bottom:10px}footer .h4,footer h4,header .h4,header h4{font-weight:600;margin:0;padding-bottom:10px}footer .h6,footer h6,header .h6,header h6{font-weight:400;margin:0;padding-bottom:10px}footer .display-1,footer .display-2,footer .display-3,footer .display-4,header .display-1,header .display-2,header .display-3,header .display-4{font-family:HelveticaNeueLight,Helvetica,Roboto,"Segoe UI",Arial,sans-serif;font-weight:lighter}footer .h1,footer h1,header .h1,header h1{font-size:32px;line-height:40px}footer .h2,footer h2,header .h2,header h2{font-size:26px;line-height:33px}footer .h3,footer h3,header .h3,header h3{font-size:22px;line-height:28px}footer .h4,footer h4,header .h4,header h4{font-size:20px;line-height:25px}footer .h5,footer h5,header .h5,header h5{font-size:18px;line-height:23px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}@media (max-width:768px){footer .h1,footer h1,header .h1,header h1{font-size:26px;line-height:33px}footer .h2,footer h2,header .h2,header h2{font-size:21px;line-height:26px}footer .h3,footer h3,header .h3,header h3{font-size:18px;line-height:23px}footer .h4,footer h4,header .h4,header h4{font-size:16px;line-height:20px}footer .h5,footer h5,header .h5,header h5{font-size:16px;line-height:20px}footer .h6,footer h6,header .h6,header h6{font-size:16px;line-height:20px}footer .display-1,header .display-1{font-size:40px;line-height:50px}footer .display-2,header .display-2{font-size:32px;line-height:40px}footer .display-3,header .display-3{font-size:24px;line-height:30px}footer .display-4,header .display-4{font-weight:300;font-size:30px;line-height:38px}}footer .font-size-14,header .font-size-14{font-size:14px}footer .font-size-16,header .font-size-16{font-size:16px}footer .font-size-18,header .font-size-18{font-size:18px}footer .font-size-20,header .font-size-20{font-size:20px}footer .font-size-22,header .font-size-22{font-size:22px}footer .font-size-24,header .font-size-24{font-size:24px}footer .font-size-26,header .font-size-26{font-size:26px}footer fieldset,header fieldset{display:block;margin-inline-start:0;margin-inline-end:0;padding-block-start:0;padding-inline-start:0;padding-inline-end:0;padding-block-end:0;border-width:0;border-style:none}@media print{footer .cmp-p-pageheadinghero,header .cmp-p-pageheadinghero{display:none}footer .cmp-p-manualnav,header .cmp-p-manualnav{display:none}footer .header-cmp,header .header-cmp{display:none}footer .cmp-p-anchorlist,header .cmp-p-anchorlist{display:none}footer .cmp-p-ctaitem,header .cmp-p-ctaitem{display:none}footer .footer,header .footer{display:none}footer .cmp-p-testimonial,header .cmp-p-testimonial{display:none}footer td,footer th,header td,header th{padding-top:4px;padding-bottom:4px;height:30px}}.m-l1{margin:16px}.m-l2{margin:24px}.m-l3{margin:32px}.m-l4{margin:48px}.m-l5{margin:64px}.m-l0{margin:0!important}.mx-l1{margin:0 16px}.mx-l2{margin:0 24px}.mx-l3{margin:0 32px}.mx-l4{margin:0 48px}.mx-l5{margin:0 64px}.mx-l1{margin:16px 0}.mx-l2{margin:24px 0}.mx-l3{margin:32px 0}.mx-l4{margin:48px 0}.mx-l5{margin:64px 0}.mt-l1{margin-top:16px}.mt-l2{margin-top:24px}.mt-l3{margin-top:32px}.mt-l4{margin-top:48px}.mt-l5{margin-top:64px}.mb-l1{margin-bottom:16px}.mb-l2{margin-bottom:24px}.mb-l3{margin-bottom:32px}.mb-l4{margin-bottom:48px}.mb-l5{margin-bottom:64px}.ml-l1{margin-left:16px}.ml-l2{margin-left:24px}.ml-l3{margin-left:32px}.ml-l4{margin-left:48px}.ml-l5{margin-left:64px}.mr-l1{margin-right:16px}.mr-l2{margin-right:24px}.mr-l3{margin-right:32px}.mr-l4{margin-right:48px}.mr-l5{margin-right:64px}.p-l1{padding:16px}.p-l2{padding:24px}.p-l3{padding:32px}.p-l4{padding:48px}.p-l5{padding:64px}.p-l0{padding:0!important}.px-l1{padding:0 16px}.px-l2{padding:0 24px}.px-l3{padding:0 32px}.px-l4{padding:0 48px}.px-l5{padding:0 64px}.px-l1{padding:16px 0}.px-l2{padding:24px 0}.px-l3{padding:32px 0}.px-l4{padding:48px 0}.px-l5{padding:64px 0}.pt-l1{padding-top:16px}.pt-l2{padding-top:24px}.pt-l3{padding-top:32px}.pt-l4{padding-top:48px}.pt-l5{padding-top:64px}.pb-l1{padding-bottom:16px}.pb-l2{padding-bottom:24px}.pb-l3{padding-bottom:32px}.pb-l4{padding-bottom:48px}.pb-l5{padding-bottom:64px}.pl-l1{padding-left:16px}.pl-l2{padding-left:24px}.pl-l3{padding-left:32px}.pl-l4{padding-left:48px}.pl-l5{padding-left:64px}.pr-l1{padding-right:16px}.pr-l2{padding-right:24px}.pr-l3{padding-right:32px}.pr-l4{padding-right:48px}.pr-l5{padding-right:64px}.mt-s0{margin-top:0}.mt-s1{margin-top:2px}.mt-s2{margin-top:4px}.mt-s3{margin-top:8px}.mt-s4{margin-top:12px}.mt-s5{margin-top:16px}.mt-s6{margin-top:24px}.mt-s7{margin-top:32px}.mt-s8{margin-top:40px}.mt-s9{margin-top:48px}.mb-s0{margin-bottom:0}.mb-s1{margin-bottom:2px}.mb-s2{margin-bottom:4px}.mb-s3{margin-bottom:8px}.mb-s4{margin-bottom:12px}.mb-s5{margin-bottom:16px}.mb-s6{margin-bottom:24px}.mb-s7{margin-bottom:32px}.mb-s8{margin-bottom:40px}.mb-s9{margin-bottom:48px}.ml-s0{margin-left:0}.ml-s1{margin-left:2px}.ml-s2{margin-left:4px}.ml-s3{margin-left:8px}.ml-s4{margin-left:12px}.ml-s5{margin-left:16px}.ml-s6{margin-left:24px}.ml-s7{margin-left:32px}.ml-s8{margin-left:40px}.ml-s9{margin-left:48px}.mr-s0{margin-right:0}.mr-s1{margin-right:2px}.mr-s2{margin-right:4px}.mr-s3{margin-right:8px}.mr-s4{margin-right:12px}.mr-s5{margin-right:16px}.mr-s6{margin-right:24px}.mr-s7{margin-right:32px}.mr-s8{margin-right:40px}.mr-s9{margin-right:48px}.pt-s0{padding-top:0}.pt-s1{padding-top:2px}.pt-s2{padding-top:4px}.pt-s3{padding-top:8px}.pt-s4{padding-top:12px}.pt-s5{padding-top:16px}.pt-s6{padding-top:24px}.pt-s7{padding-top:32px}.pt-s8{padding-top:40px}.pt-s9{padding-top:48px}.pb-s0{padding-bottom:0}.pb-s1{padding-bottom:2px}.pb-s2{padding-bottom:4px}.pb-s3{padding-bottom:8px}.pb-s4{padding-bottom:12px}.pb-s5{padding-bottom:16px}.pb-s6{padding-bottom:24px}.pb-s7{padding-bottom:32px}.pb-s8{padding-bottom:40px}.pb-s9{padding-bottom:48px}.pl-s0{padding-left:0}.pl-s1{padding-left:2px}.pl-s2{padding-left:4px}.pl-s3{padding-left:8px}.pl-s4{padding-left:12px}.pl-s5{padding-left:16px}.pl-s6{padding-left:24px}.pl-s7{padding-left:32px}.pl-s8{padding-left:40px}.pl-s9{padding-left:48px}.pr-s0{padding-right:0}.pr-s1{padding-right:2px}.pr-s2{padding-right:4px}.pr-s3{padding-right:8px}.pr-s4{padding-right:12px}.pr-s5{padding-right:16px}.pr-s6{padding-right:24px}.pr-s7{padding-right:32px}.pr-s8{padding-right:40px}.pr-s9{padding-right:48px}footer{padding-top:40px;background-color:#fff}footer .footer .footer-menu{width:100%;background-color:#f7f7f7;padding:0}footer .footer .footer-menu-container{max-width:1440px;margin:auto;padding:0;font-size:14px;display:flex;justify-content:space-between;flex-direction:column}footer .footer .footer-menu-col{padding-bottom:8px}footer .footer .footer-menu-col ul{list-style-type:none;margin-left:0;padding-inline-start:0;max-height:0;transition:height .3s ease-in;overflow:hidden;margin-bottom:-12px}footer .footer .footer-menu-col ul li{font-weight:400;line-height:24px}footer .footer .footer-menu-col ul li .external-link-icon{height:16px;width:16px;margin-left:10px;margin-bottom:-2px;display:inline-block;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16'%3E%3Cpath class='external-link-icon' d='M15 1V8.24H13V4.4l-6 6L5.56 9l6-6H7.75V1ZM11.28 13.09H2.89V4.7H5.61V2.8H1V15H13.17v-4.7H11.28Z'/%3E%3C/svg%3E")}footer .footer .footer-menu-col.open .footer-menu-label .icon .plus-icon-svg{display:none}footer .footer .footer-menu-col.open .footer-menu-label .icon .minus-icon-svg{display:inline-block}footer .footer .footer-menu-col.open ul{max-height:500px;transition:height .3s ease-out;margin:0 16px 16px}footer .footer .footer-menu-label{font-weight:700;line-height:22px;padding:16px;border-top:1px solid #e5e5e5}footer .footer .footer-menu-label .icon{float:right;margin-right:16px;width:24px;display:inline-block;pointer-events:none}footer .footer .footer-menu-label .icon .minus-icon-svg{display:none}footer .footer .footer-menu-label a,footer .footer .footer-menu-label a:visited{color:#222}footer .footer .footer-legal{width:100%}footer .footer .footer-legal-container{max-width:1440px;margin:auto;padding:0 16px;display:flex;justify-content:space-between;flex-direction:column;font-size:14px}footer .footer .footer-legal-container-select{display:inline-block;text-align:left;justify-content:flex-start;align-items:center;font-weight:500;font-size:14px;line-height:22px;width:100%;margin-bottom:16px}footer .footer .footer-legal-container-select .ml-l1{margin-left:0;margin-right:0}footer .footer .footer-legal-container-select select{margin-bottom:0;background-color:transparent}footer .footer .footer-legal-container-select label{display:block;padding-bottom:6px;padding-right:12px}footer .footer .footer-legal-container-select .cmp-ctaitem{margin-top:0}footer .footer .footer-legal-container-select .cmp-ctaitem button{display:inline-block;text-align:center;margin:0;border-radius:3px;font-weight:700;font-size:14px;padding:0 24px 0 24px;box-sizing:border-box;line-height:32px;text-decoration:none;cursor:pointer;transition:background 250ms ease-in-out,transform 150ms ease;-webkit-appearance:none;-moz-appearance:none;width:auto;color:#555759;background-color:#fff;border:solid 1px #dcdcdc}footer .footer .footer-legal-container-select .cmp-ctaitem__anchor{margin-left:16px}footer .footer .footer-legal-container-select .cmp-p-dropdown{display:inherit;float:left;margin-right:16px}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown{position:relative}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggle{border:1px solid #ccc;border-left:4px solid #0079d8;min-width:220px;text-align:left;font-weight:700;line-height:30px;height:34px}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggleicon{height:0;width:0;margin:12px;border-left:4px solid transparent;border-right:4px solid transparent;border-top:6px solid #222}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown__toggleicon:after{display:none}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown select{appearance:none}footer .footer .footer-legal-container-select .cmp-p-dropdown .cmp-dropdown::after{content:"‣";position:absolute;top:6px;right:12px;font-size:34px;transform:rotate(90deg);z-index:-1}footer .footer .footer-legal-container #form-select-language{margin-top:0}footer .footer .footer-legal-container .cn-footer{color:#54545c;font-size:12px;margin-bottom:120px}footer .footer .footer-legal-link{font-size:12px;font-weight:400;line-height:15px}footer .footer .footer-legal-link ul{list-style-type:none;margin-left:0;padding-inline-start:0;margin-bottom:0}footer .footer .footer-legal-link ul li{padding-bottom:12px}footer .footer .footer-legal-link ul li a{margin-bottom:12px}footer .footer .footer-legal .all-rights{display:block;color:#54545c;margin-bottom:12px;max-width:600px}footer .footer .footer-legal-logo{width:99px;margin-top:24px}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}footer .footer .footer-legal-country{display:flex;margin-bottom:0;justify-content:flex-start}footer .footer .footer-legal-country .country-flag{height:16px;width:16px;display:inline-block;margin-right:16px}footer .footer a,footer .footer a:link,footer .footer a:visited{color:#54545c}@media (min-width:576px){footer .footer .footer-legal-container-select .cmp-p-dropdown{margin-bottom:0}footer .footer .footer-legal-link{font-size:14px;font-weight:400;line-height:22px}footer .footer .footer-legal-link ul li{padding-bottom:0;display:inline-block;padding-right:16px;padding-left:16px;border-right:1px solid #dcdcdc}footer .footer .footer-legal-link ul li:first-child{padding-left:0}footer .footer .footer-legal-link ul li:last-child{border-right:none}footer .footer .footer-legal-list .privacy-policy-bold{font-weight:700}}@media (min-width:768px){footer .footer .footer-legal-link{font-size:11px;line-height:13px;display:flex;align-items:center}footer .footer .footer-legal-logo{width:120px;margin:16px 0}footer .footer .footer-legal-logo .tf-logo-cls-1{fill:#e71316}footer .footer .footer-legal-logo .tf-logo-cls-2{fill:#fff}footer .footer .footer-legal-list{width:100%;margin-left:24px}footer .footer .footer-legal-list ul{margin-top:0;margin-bottom:0}footer .footer .footer-legal-list li{margin-bottom:10px}footer .footer .footer-legal-list .privacy-policy-bold{font-weight:700}footer .footer .footer-legal .all-rights{display:block;color:#54545c;margin-bottom:12px;max-width:600px}footer .footer .footer-legal-country{margin-bottom:14px;min-width:140px}footer .footer .footer-legal .footer-legal-country{display:flex;margin-top:16px;justify-content:flex-end}footer .footer .footer-legal .footer-legal-country .country-flag{height:24px;margin-right:5px}}@media (min-width:992px){footer .footer .footer-menu{padding:0 24px}footer .footer .footer-menu-container{flex-direction:row;padding:0 16px}footer .footer .footer-menu-col{margin-top:0;margin-block-start:14px}footer .footer .footer-menu-col.open ul{margin:0}footer .footer .footer-menu-col ul{display:block;max-height:500px;padding-bottom:42px;margin-block-start:9px}footer .footer .footer-menu-col ul li{min-height:30px}footer .footer .footer-menu-label{border-top:none;padding:16px 0 0}footer .footer .footer-menu-label .icon{display:none}footer .footer .footer-legal-container{padding-bottom:42px;margin-top:24px}footer .footer .footer-legal-container .cn-footer{margin-bottom:0}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}}@media (min-width:1200px){footer .footer .footer-legal-container-select{display:flex;text-align:left;align-self:flex-end;justify-content:flex-end;align-items:center;font-weight:500;font-size:14px;line-height:22px;width:100%;margin-bottom:16px}footer .footer .footer-legal-container #form-select-language{margin-top:-32px}footer .footer .footer-legal .privacy-policy-bold{font-weight:700}}.cmp-dropdown{position:relative}.cmp-dropdown *{box-sizing:border-box}.cmp-dropdown .cmp-dropdown__toggle{position:relative;display:inline-block;padding:0 30px 0 10px;line-height:40px;border:1px solid #222;text-decoration:none;color:#222}.cmp-dropdown .cmp-dropdown__toggleicon{position:absolute;height:40px;width:20px;transform:translate(0,0);top:0;right:0}.cmp-dropdown .cmp-dropdown__toggleicon:after{font-family:icomoon;font-size:8px;content:"\ee2c";display:inline-block}.cmp-dropdown .cmp-dropdown__menu{display:none;position:absolute;z-index:1;transform:translate(0,0);will-change:transform;padding:5px;background-color:#eee;border:1px solid #222}.cmp-dropdown.open .cmp-dropdown__toggleicon:after{transform:rotate(180deg)}.cmp-dropdown.open .cmp-dropdown__menu{display:block}.footer-menu-container ul li a img{width:14px;height:14px;top:2px;position:relative} /*# sourceMappingURL=footer.min.css.map */ </style> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/utilities.min.468bd07150dbbf.js" async></script>  <div class="footer "> <div class="footer-menu"> <div class="footer-menu-container"> <div id="footer-menu-category-1" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Ordering" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> Ordering <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-1" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/store/orders/solu" onclick="" id="footer-link-1-1" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Order Status">Order Status <span></span> </a> </li> <li> <a href="/sg/en/home/support/how-to-place-orders.html" onclick="" id="footer-link-1-4" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Order Help">Order Help <span></span> </a> </li> <li> <a href="/store/v2/quick-order" onclick="" id="footer-link-1-5" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Quick Order">Quick Order <span></span> </a> </li> <li> <a href="/sg/en/home/products-and-services/supply-center.html" onclick="" id="footer-link-1-6" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="Supply Center">Supply Center <span></span> </a> </li> <li> <a href="/sg/en/home/digital-solutions/ecommerce/b2b.html" onclick="" id="footer-link-1-7" data-analytics-section="footer" data-analytics-container="Ordering" data-analytics-text="eProcurement">eProcurement <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-2" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Support" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> Support <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-2" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/support.html" onclick="" id="footer-link-2-1" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Help and Support">Help and Support <span></span> </a> </li> <li> <a href="/sg/en/home/technical-resources/contact-us.html" onclick="" id="footer-link-2-2" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Contact Us">Contact Us <span></span> </a> </li> <li> <a href="/sg/en/home/technical-resources/technical-reference-library.html" onclick="" id="footer-link-2-3" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Technical Support Centers">Technical Support Centers <span></span> </a> </li> <li> <a href="/sg/en/home/support/documents-certificates.html" onclick="" id="footer-link-2-4" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Documents and Certificates">Documents and Certificates <span></span> </a> </li> <li> <a href="javascript:KAMPYLE_ONSITE_SDK.showForm(29308);void(0);" onclick="" id="footer-link-2-5" data-analytics-section="footer" data-analytics-container="Support" data-analytics-text="Report a Site Issue">Report a Site Issue <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-3" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Resources" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> Resources <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-3" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/technical-resources/learning-centers.html" onclick="" id="footer-link-3-1" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Learning Centers">Learning Centers <span></span> </a> </li> <li> <a href="/sg/en/home/products-and-services/promotions.html" onclick="" id="footer-link-3-2" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Promotions">Promotions <span></span> </a> </li> <li> <a href="/sg/en/home/about-us/events.html" onclick="" id="footer-link-3-3" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Events and Webinars">Events and Webinars <span></span> </a> </li> <li> <a href="/sg/en/home/communities-social/socialhub.html" onclick="" id="footer-link-3-4" data-analytics-section="footer" data-analytics-container="Resources" data-analytics-text="Social Media">Social Media <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-4" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> About Thermo Fisher <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-4" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="https://corporate.thermofisher.com/en/home.html" onclick="" id="footer-link-4-1" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="About Us">About Us <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="About Us"> <span></span> </a> </li> <li> <a href="https://jobs.thermofisher.com/global/en" onclick="" id="footer-link-4-2" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Careers">Careers <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Careers"> <span></span> </a> </li> <li> <a href="http://ir.thermofisher.com/investors/Investor-Overview/default.aspx" onclick="" id="footer-link-4-3" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Investors">Investors <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Investors"> <span></span> </a> </li> <li> <a href="https://thermofisher.mediaroom.com" onclick="" id="footer-link-4-4" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="News">News <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="News"> <span></span> </a> </li> <li> <a href="http://corporate.thermofisher.com/en/responsibility.html" onclick="" id="footer-link-4-5" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Social Responsibility">Social Responsibility <img src="/store/global-header-footer-static/global/svg/external-link-bold.svg" alt="Social Responsibility"> <span></span> </a> </li> <li> <a href="/sg/en/home/global/trademark-information.html" onclick="" id="footer-link-4-6" data-analytics-section="footer" data-analytics-container="About Thermo Fisher" data-analytics-text="Trademarks">Trademarks <span></span> </a> </li> </ul> </div> <div id="footer-menu-category-5" class="footer-menu-col pragma-toggle-component"> <div class="footer-menu-label pragma-toggle" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> Our Portfolio <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="plus-icon-svg" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> <title>Plus Icon</title> <g> <path d="M22,13H13v9H11V13H2V11h9V2h2v9h9Z" /> </g> </svg> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" class="minus-icon-svg" data-toggle="#footer-menu-category-5" data-toggle-classes="open"> <title>Minus Icon</title> <g> <path d="M22,11v2H2V11Z" /> </g> </svg> </span> </div> <ul> <li> <a href="/sg/en/home/brands/thermo-scientific.html" onclick="" id="footer-link-5-1" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Thermo Scientific">Thermo Scientific <span></span> </a> </li> <li> <a href="/sg/en/home/brands/applied-biosystems.html" onclick="" id="footer-link-5-2" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Applied Biosystems">Applied Biosystems <span></span> </a> </li> <li> <a href="/sg/en/home/brands/invitrogen.html" onclick="" id="footer-link-5-3" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Invitrogen">Invitrogen <span></span> </a> </li> <li> <a href="/sg/en/home/brands/gibco.html" onclick="" id="footer-link-5-4" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Gibco">Gibco <span></span> </a> </li> <li> <a href="/sg/en/home/brands/ion-torrent.html" onclick="" id="footer-link-5-5" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Ion Torrent">Ion Torrent <span></span> </a> </li> <li> <a href="/sg/en/home/brands/fisher-scientific.html" onclick="" id="footer-link-5-6" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Fisher Scientific">Fisher Scientific <span></span> </a> </li> <li> <a href="/sg/en/home/brands/patheon.html" onclick="" id="footer-link-5-7" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="Patheon">Patheon <span></span> </a> </li> <li> <a href="/sg/en/home/brands/ppd.html" onclick="" id="footer-link-5-8" data-analytics-section="footer" data-analytics-container="Our Portfolio" data-analytics-text="PPD">PPD <span></span> </a> </li> </ul> </div> </div> </div> <div class="footer-legal"> <div class="footer-legal-container"> <div class="footer-legal-link "> <div class="footer-legal-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 485.52 223.55"> <defs> <style> .tf-logo-cls-1 { fill: #ee3134; } .tf-logo-cls-2 { fill: #fff; } </style> </defs> <rect class="tf-logo-cls-1" width="485.52" height="223.55"/> <path class="tf-logo-cls-2" d="M108.27,83.11V76h-32v7.13h11v31h9.92v-31Zm123.5,31c-.26-2.53-.42-4.49-.42-5.81V95.46c0-5.33-3.91-8.65-9.08-8.65a10.21,10.21,0,0,0-8.82,4.69c-1.11-3-4.38-4.54-7.44-4.54-3.7,0-6.81,1.22-8.55,4.54l-.22-4h-9.07V114.1h9.39v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.59,2.59,3.59,5.12V114.1h9.34v-16c0-.84-.37-5.38,4-5.38,2.91,0,3.6,2.59,3.6,5.12V114.1ZM186,95.35V87.28c-4.07,0-7.18,1.27-8.39,5.33l-.22-5.07H168c.21,2.17.21,5.07.21,6.82V114.1h9.4V102.48c0-4.38,1.26-7.07,6.44-7.17.63,0,1.26,0,1.95,0m62-8.54c-8.66,0-14.31,4.8-14.31,13.93,0,9.4,5.71,14.1,14.31,14.1s14.31-4.7,14.31-14.1c0-9.13-5.65-13.93-14.31-13.93m0,5.59c4,0,4.7,4.06,4.7,8.23,0,4.86-.85,8.66-4.7,8.66s-4.7-3.8-4.7-8.66c0-4.22.74-8.28,4.7-8.28ZM137.21,114.1a57.55,57.55,0,0,1-.37-5.81V95.46c0-5.33-4-8.65-9.13-8.65a11.12,11.12,0,0,0-4.44.84,9.58,9.58,0,0,0-3.38,2.69V76H110.5V114.1h9.39v-16c0-.84-.36-5.38,4-5.38,3,0,3.59,2.59,3.59,5.12V114.1Zm28.72-11.46c0-9.55-2.8-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.88,14.78a14.49,14.49,0,0,0,8.24-2.22,9.58,9.58,0,0,0,4.49-7.29h-8.87a4.15,4.15,0,0,1-4.49,4.07c-3.59,0-4.32-3.43-4.27-6.76Zm-9-5.12h-8.71c.21-2.8.84-5.65,4.32-5.8a3.49,3.49,0,0,1,3.33,1.84,7.36,7.36,0,0,1,1.06,4Z"/> <path class="tf-logo-cls-2" d="M409.29,94.88V86.81c-4.06-.06-7.18,1.26-8.39,5.33l-.21-4.6H391.3c.2,2.17.2,5.07.2,6.81v19.74h9.4V102.48c0-4.38,1.27-7.54,6.44-7.65.63,0,1.26,0,2,0m-48.87,19.21a54.56,54.56,0,0,1-.37-5.8V95.47c0-5.34-4-8.66-9.13-8.66a10.52,10.52,0,0,0-4.33.84,9.73,9.73,0,0,0-3.49,2.69V76h-9.39v38.11h9.39v-16c0-.84-.37-5.38,4-5.38,2.95,0,3.59,2.58,3.59,5.12v16.25Zm-29-7.91c0-4.12-2.16-6.12-5.17-7.23-5.65-2-9.88-2.11-9.88-4.23a2.24,2.24,0,0,1,2.44-2.48,3.34,3.34,0,0,1,2.52.85,3.7,3.7,0,0,1,.69,2.53h8.92c-.21-7-5.7-8.81-11.72-8.81-5.12,0-11.76,1.79-11.76,8.18,0,9.29,15,6.86,15,11.82,0,1.75-1.43,2.53-3.28,2.53a2.92,2.92,0,0,1-2.42-1.26,3.36,3.36,0,0,1-.58-2.59h-9c-.16,7.92,5.7,9.35,12.19,9.35,6.08,0,12-2.22,12-8.66m57.78-3.54c.06-9.55-2.79-15.83-13.41-15.83-8.39,0-13.41,5.17-13.41,13.25,0,9.92,3.54,14.78,13.89,14.78a14.56,14.56,0,0,0,8.23-2.22,9.52,9.52,0,0,0,4.49-7.29H380.1a4.14,4.14,0,0,1-4.48,4.07c-3.59,0-4.33-3.43-4.28-6.76Zm-9-5.12H371.5c.21-2.8.84-5.65,4.33-5.8a3.51,3.51,0,0,1,3.33,1.85,7.38,7.38,0,0,1,1,4Zm-75.39-10h-9.39V114.1h9.39ZM292.5,83l2.22-7H269.47v38.11h9.92v-15h8l2.21-7H279.39V83Zm12.32,0,2.23-7h-9.29l-2.22,7Z"/> <path class="tf-logo-cls-2" d="M162.45,125.26h3.44v21.61h-3.44Zm232,22c-7.21,0-12.59-4-12.59-11s6-11.42,12.81-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.77,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.85,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.56,6.3c1.65,1.63,4.18,2.08,6.66,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.64,14.64,0,0,1-7.59,2m-36.24-22h3.44v21.61h-3.44Zm-77.92,2.58h-8.05v19h-3.36v-19h-8v-2.58h19.77ZM100.78,146.1a13.66,13.66,0,0,1-6.09,1.22A20.13,20.13,0,0,1,86,145.37l1.43-2.45a16.3,16.3,0,0,0,7.54,1.82,7.65,7.65,0,0,0,3.93-.88,3.14,3.14,0,0,0,1.9-2.79c0-1.81-1.39-2.93-4.73-3.71l-3.51-.82c-3.5-.82-5.7-3-5.7-5.56,0-3.68,3.62-6.29,8.78-6.29a16.39,16.39,0,0,1,8.29,2.06L102.33,129a13.46,13.46,0,0,0-6.55-1.73c-3.07,0-5.2,1.19-5.2,3.22,0,1.56,1.3,2.49,4.31,3.22l3.25.78a11.33,11.33,0,0,1,4.78,2.18,5.38,5.38,0,0,1,1.68,3.86,6.4,6.4,0,0,1-3.82,5.57m138.41.77-8.58-11.52c-1.61-2.16-4.33-6.38-4.33-6.38s.3,3.65.32,6.85l.09,11.05h-3.43V125.26h4.09L236,137c1.69,2.29,4,5.92,4,5.92s-.52-4-.54-6.84l-.08-10.85h3.4v21.61Zm59.2-21.61h3.45v21.61h-3.45Zm41,2.54H327.56v6.4h10v2.54h-10v10.13h-3.45V125.26h15.76ZM188.17,146.87V125.26H204.1l-.46,2.58h-12v6.44h10.24v2.58h-10.2v7.3h12.86v2.71Zm-52.36.37c-7.2,0-12.58-4-12.58-11s6-11.42,12.8-11.42a13.4,13.4,0,0,1,6.78,1.9l-1.76,2.09a10.44,10.44,0,0,0-5-1.41,9,9,0,0,0-6.86,2.64,8.89,8.89,0,0,0-2.18,6.33,7.9,7.9,0,0,0,2.57,6.3c1.65,1.63,4.17,2.08,6.65,2.08a12.1,12.1,0,0,0,5.46-1.55l1.68,2a14.59,14.59,0,0,1-7.59,2"/> </svg> </div> <div class="footer-legal-list"> <ul class="footer-legal-list"> <li class=""> <a href="/sg/en/home/global/terms-and-conditions.html" id="hfTermsOfServiceLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Terms & Conditions">Terms & Conditions</a> </li> <li class=""> <a href="/sg/en/home/global/privacy-policy.html" id="hfPrivacyPolicyLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Privacy Policy">Privacy Policy</a> </li> <li class=""> <a href="/sg/en/home/global/online-pricing-policy.html" id="hfOnlinePricePolicyLink" data-analytics-section="footer" data-analytics-container="legal" data-analytics-text="Price & Freight Policy">Price & Freight Policy</a> </li> <li> <div id="teconsent"></div> <div id="consent_blackbar"></div> </li> </ul> <div class="all-rights">© 2006-2024 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.</div> </div> <style> .test-svg { font-size: 14px; } </style> <div class="footer-legal-country"> <div class="country-flag"> <img class="country-flag-img" src="/store/global-header-footer-static/global/images/flags/sg.gif" alt="Singapore flag icon" data-uw-rm-ima-original="Singapore flag icon"> </div> <div class="country-name">Singapore</div> </div> </div>  <script type="text/javascript"> if(document.getElementById('language-select')){ var myOpts = document.getElementById('language-select').options; for(var i = 0; i < myOpts.length; i++){ if((window.location.pathname.split("/")[2] == myOpts[i].value) || (getCookie('CK_LANG_CODE') == myOpts[i].value)){ myOpts[i].setAttribute("selected", "selected"); } } } </script> </div> </div> <script> // DTM footer init if ( window._satellite && window._satellite.pageBottom ) { window._satellite.pageBottom(); } </script> <script> /* START: Global header promo config */ // var globalHeaderPromoConfig = { // "Promos": [ // { // "Text":"Ordering online is fast & simple.", // "LinkText":"Register today", // "ISO": "us ca", //use this if you need to restrict to an iso // "LANG": "en", //use this if you need to restrict to a certain language // "URL": "/auth/create-account&ICID=L0-HP-TB-EBIZ-RS001-registeronline-20160921-SG", // "URLAppendISO": false //If using an ICID, you can use this to have the current ISO automatically appended // } // ], // "Config": { // 'HideDisplayTypes':'B2B SCMS' // } // }; /* END: Global header promo config */ /* START: Global Header Promo Display Logic */ // function initGlobalHeaderPromo(){ // if ( typeof(globalHeaderPromoConfig) === 'object' ) { // $('.global-promo').remove(); //Do not display promo for B2B. You can change these display types in the config file. // var hideDisplayTypes = globalHeaderPromoConfig.Config.HideDisplayTypes.split(" "); // for( var i=0; i< hideDisplayTypes.length;i++){ // if ( _lt.displayTypeMatch( hideDisplayTypes[i]) ) return false; // } //Ok Usertype? Let's go for it, then... Let's loop through our promos and see if they can be displayed for this user // for ( var promoKey in globalHeaderPromoConfig.Promos ) { // var thisPromo = globalHeaderPromoConfig.Promos[promoKey]; // if ( thisPromo.ISO && !_lt.displayIsoMatch( thisPromo.ISO ) ) continue; // if ( thisPromo.LANG && !_lt.displayLangMatch( thisPromo.LANG ) ) continue; //Append the current user's ISO code to the end of the URL ( for tracking ) // if ( thisPromo.URLAppendISO && thisPromo.URLAppendISO !== false ) { // thisPromo.URL = thisPromo.URL+'-'+_lt.user.displayIso; // } // if ( window.messagingBar ) window.messagingBar.addPromo(thisPromo.Text,thisPromo.LinkText,thisPromo.URL); //Promo displayed - let's return true // return true; // } //Promo Loop // } //Config Check //Promo did not display.. Return false. // return false; // } // $(document).ready(initGlobalHeaderPromo) ; /* END: Global Header Promo Display Logic */ </script>  <style> /* turn bar red - THIS IS ONLY for emergencies */ /* #messagingBar.messaging-bar-promos { background: #ee3134; }*/ /* #messagingBarClose{display:none !important } */ </style>  <style> @media(min-width: 980px) { .template-2-column .mondrian-module-f { height: auto !important; } .mondrian-featured-list { display: table; height: 100%; margin: 0; padding: 0; position: relative; width: 100%; } .mondrian-module-list ul li, .mondrian-module-list ul.default li, .mondrian-module-list ul.mondrian-featured-list li { display: table-row !important; border-bottom: 1px solid #fff !important; border-bottom-width: 1px !important; border-bottom-style: solid !important; border-bottom-color: rgb(255, 255, 255) !important; word-break: normal !important; } } @media(min-width:767px) { .mondrian-module-list ul li, .mondrian-module-list ul.default li, .mondrian-module-list ul.mondrian-featured-list li { display: table-row!important; border-bottom: 1px solid #fff !important; word-break: normal !important; } } </style> </div>    <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("globalFooter:renderEnd"); </script> <script id="localizedCountriesInfoURL" type="text/javascript"> var ltCountryInfo = {"af":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/af.gif","name":"Afghanistan","phone":"\t<a href='/af/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"al":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/al.gif","name":"Albania","phone":"<a href='/al/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"dz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dz.gif","name":"Algeria","phone":"<a href='/dz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ad":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ad.gif","name":"Andorra","phone":"<a href='/ad/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ao":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ao.gif","name":"Angola","phone":"<a href='/ao/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"aq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/emptyflag.gif","name":"Antarctica","phone":"<a href='/aq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ag":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ag.gif","name":"Antigua and Barbuda","phone":"<a href='/ag/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ar":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/ar.gif","name":"Argentina","phone":"<a href='/ar/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_AR"},"aw":{"defaultLanguage":"en","name":"Aruba","phone":"<a href='/aw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"am":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/am.gif","name":"Armenia","phone":"<a href='/am/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"au":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/au.gif","name":"Australia","phone":"<a href='/au/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"at":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/at.gif","name":"Austria","phone":"<a href='/at/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"az":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/az.gif","name":"Azerbaijan","phone":"<a href='/az/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bs.gif","name":"Bahamas","phone":"<a href='/bs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bh.gif","name":"Bahrain","phone":"<a href='/bh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bd.gif","name":"Bangladesh","phone":"<a href='/bd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"bb":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bb.gif","name":"Barbados","phone":"<a href='/bb/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"by":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/by.gif","name":"Belarus","phone":"<a href='/by/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"be":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/be.gif","name":"Belgium","phone":"<a href='/be/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"bz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bz.gif","name":"Belize","phone":"<a href='/bz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bj.gif","name":"Benin","phone":"<a href='/bj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bm.gif","name":"Bermuda","phone":"<a href='/bm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"bt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bt.gif","name":"Bhutan","phone":"<a href='/in/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SA"},"bo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bo.gif","name":"Bolivia","phone":"<a href='/bo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ba":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ba.gif","name":"Bosnia and Herzegovina","phone":"<a href='/ba/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bw.gif","name":"Botswana","phone":"<a href='/bw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bv.gif","name":"Bouvet Island","phone":"<a href='/bv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"br":{"defaultLanguage":"pt","flag":"/shared-static/images/icons/flags/br.gif","name":"Brasil","phone":"<a href='/br/en/home/technical-resources/contact-us.html'>Contato</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_BR"},"bn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bn.gif","name":"Brunei Darussalam","phone":"<a href='/bn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"bg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bg.gif","name":"Bulgaria","phone":"<a href='/bg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bf.gif","name":"Burkina Faso","phone":"<a href='/bf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"bi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/bi.gif","name":"Burundi","phone":"<a href='/bi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kh.gif","name":"Cambodia","phone":"<a href='/kh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"cm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cm.gif","name":"Cameroon","phone":"<a href='/cm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ca":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ca.gif","name":"Canada","phone":"<a href='/ca/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"1","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.ca","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"NA"},"ic":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ic.gif","name":"Canary Islands","phone":"<a href='/ic/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cv.gif","name":"Cape Verde","phone":"<a href='/cv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ky":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ky.gif","name":"Cayman Islands","phone":"<a href='/ky/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cf.gif","name":"Central African Republic","phone":"<a href='/cf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"td":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/td.gif","name":"Chad","phone":"<a href='/td/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cl":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/cl.gif","name":"Chile","phone":"<a href='/cl/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_CL"},"cn":{"defaultLanguage":"zh","flag":"/shared-static/images/icons/flags/cn.gif","name":"China | 中国","phone":"<a href='/cn/en/home/technical-resources/contact-us.html'>联系我们</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"2","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brandGroup":"1","groupDisplay":"","regionMapping":"GC_CN"},"co":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/co.gif","name":"Colombia","phone":"<a href='/co/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"km":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/km.gif","name":"Comoros","phone":"<a href='/km/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cg.gif","name":"Congo","phone":"<a href='/cg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":" Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cd.gif","name":"Congo (Democratic Republic of)","phone":"<a href='/cd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cr.gif","name":"Costa Rica","phone":"<a href='/cr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ci":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ci.gif","name":"Cote Dlvoire (Ivory Coast)","phone":"<a href='/ci/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"hr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hr.gif","name":"Croatia (Hrvatska)","phone":"<a href='/hr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cw":{"defaultLanguage":"en","name":"Curaçao","phone":"<a href='/cw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"cy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cy.gif","name":"Cyprus","phone":"<a href='/cy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"cz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cz.gif","name":"Czech Republic","phone":"<a href='/cz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"dk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dk.gif","name":"Denmark","phone":"<a href='/dk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"dj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dj.gif","name":"Djibouti","phone":"<a href='/dj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"dm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/dm.gif","name":"Dominica","phone":"<a href='/dm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"do":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/do.gif","name":"Dominican Republic","phone":"<a href='/do/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ec":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ec.gif","name":"Ecuador","phone":"<a href='/ec/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"eg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/eg.gif","name":"Egypt","phone":"<a href='/eg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services ","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sv.gif","name":"El Salvador","phone":"<a href='/sv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"er":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/er.gif","name":"Eritrea","phone":"<a href='/er/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ee":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ee.gif","name":"Estonia","phone":"<a href='/ee/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"et":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/et.gif","name":"Ethiopia","phone":"<a href='/et/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"fo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fo.gif","name":"Faroe Islands","phone":"<a href='/fo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"fj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fj.gif","name":"Fiji","phone":"<a href='/fj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"fi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fi.gif","name":"Finland","phone":"<a href='/fi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"fr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/fr.gif","name":"France Metropolitan","phone":"<a href='/fx/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gf.gif","name":"French Guyana","phone":"<a href='/gf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pf":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pf.gif","name":"French Polynesia","phone":"<a href='/pf/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_AA"},"ga":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ga.gif","name":"Gabon","phone":"<a href='/ga/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gm.gif","name":"Gambia","phone":"<a href='/gm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ge":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ge.gif","name":"Georgia","phone":"<a href='/ge/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"de":{"defaultLanguage":"de","flag":"/shared-static/images/icons/flags/de.gif","name":"Germany | Deutschland","phone":"<a href='/de/en/home/technical-resources/contact-us.html'>Kontaktieren Sie uns</a>","signInHidden":"","registerHidden":"","euCountry":true,"quickLinkIndex":"3","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"gh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gh.gif","name":"Ghana","phone":"<a href='/gh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gi.gif","name":"Gibraltar","phone":"<a href='/gi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"gr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gr.gif","name":"Greece","phone":"<a href='/gr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gl.gif","name":"Greenland","phone":"<a href='/gl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gd":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gd.gif","name":"Grenada","phone":"<a href='/gd/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gp":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gp.gif","name":"Guadeloupe","phone":"<a href='/gp/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gu.gif","name":"Guam","phone":"<a href='/gu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SEA"},"gt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gt.gif","name":"Guatemala","phone":"<a href='/gt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"gn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gn.gif","name":"Guinea","phone":"<a href='/gn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gy.gif","name":"Guyana","phone":"<a href='/gy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ht":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ht.gif","name":"Haiti","phone":"<a href='/ht/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"hn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hn.gif","name":"Honduras","phone":"<a href='/hn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"hk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cn.gif","name":"Hong Kong","phone":"<a href='/tw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"GC"},"hu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/hu.gif","name":"Hungary","phone":"<a href='/hu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"is":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/is.gif","name":"Iceland","phone":"<a href='/is/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"in":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/in.gif","name":"India","phone":"<a href='/in/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"4","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.in","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"id":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/id.gif","name":"Indonesia","phone":"<a href='/id/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"iq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/iq.gif","name":"Iraq","phone":"<a href='/iq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ie":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ie.gif","name":"Ireland","phone":"<a href='/ie/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"il":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/il.gif","name":"Israel","phone":"<a href='/il/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"it":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/it.gif","name":"Italy","phone":"<a href='/it/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"jm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/jm.gif","name":"Jamaica","phone":"<a href='/jm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"jp":{"defaultLanguage":"ja","flag":"/shared-static/images/icons/flags/jp.gif","name":"Japan | 日本","phone":"<a href='/jp/en/home/technical-resources/contact-us.html'>お問い合わせ</a>","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"5","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"/jp/ja/home/brands/fisher-scientific.html","brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"JP"},"jo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/jo.gif","name":"Jordan","phone":"<a href='/jo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kz.gif","name":"Kazakhstan","phone":"<a href='/kz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ke":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ke.gif","name":"Kenya","phone":"<a href='/ke/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kr":{"defaultLanguage":"ko","flag":"/shared-static/images/icons/flags/kr.gif","name":"Korea | 대한민국","phone":"<a href='/kr/en/home/technical-resources/contact-us.html'>연락처</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"/content/lifetech/global/en/home/brands/fisher-scientific","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_KR"},"kw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kw.gif","name":"Kuwait","phone":"<a href='/kw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kg.gif","name":"Kyrgyzstan","phone":"<a href='/kg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"la":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/la.gif","name":"Laos","phone":"<a href='/la/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_SEA"},"lv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lv.gif","name":"Latvia","phone":"<a href='/lv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lb":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lb.gif","name":"Lebanon","phone":"<a href='/lb/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ls":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ls.gif","name":"Lesotho","phone":"<a href='/ls/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"defaultcountry":{"defaultLanguage":"en","name":"Default Country","phone":"","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"groupDisplay":""},"lr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lr.gif","name":"Liberia","phone":"<a href='/lr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ly":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ly.gif","name":"Libya","phone":"<a href='/ly/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"li":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/li.gif","name":"Liechtenstein","phone":"<a href='/li/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":" Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"lt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lt.gif","name":"Lithuania","phone":"<a href='/lt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lu.gif","name":"Luxembourg","phone":"<a href='/lu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"mo":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/cn.gif","name":"Macau","phone":"<a href='/mo/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mk.gif","name":"Macedonia","phone":"<a href='/mk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mg.gif","name":"Madagascar","phone":"<a href='/mg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mw.gif","name":"Malawi","phone":"<a href='/mw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"my":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/my.gif","name":"Malaysia","phone":"<a href='/my/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com.my","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"mv":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mv.gif","name":"Maldives","phone":"<a href='/mv/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"ml":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ml.gif","name":"Mali","phone":"<a href='/ml/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mt.gif","name":"Malta","phone":"<a href='/mt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mq":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mq.gif","name":"Martinique","phone":"<a href='/mq/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"mr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mr.gif","name":"Mauritania","phone":"<a href='/mr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mu":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mu.gif","name":"Mauritius","phone":"<a href='/mu/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"yt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/yt.gif","name":"Mayotte","phone":"<a href='/yt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mx":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/mx.gif","name":"México","phone":"<a href='/mx/en/home/technical-resources/contact-us.html'>Contacto</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_MX"},"md":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/md.gif","name":"Moldova","phone":"<a href='/md/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mc.gif","name":"Monaco","phone":"<a href='/mc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"mn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mn.gif","name":"Mongolia","phone":"<a href='/mn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"me":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/me.gif","name":"Montenegro","phone":"<a href='/me/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ms":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ms.gif","name":"Montserrat","phone":"<a href='/ms/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ma":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ma.gif","name":"Morocco","phone":"<a href='/ma/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mz.gif","name":"Mozambique","phone":"<a href='/mz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"mm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/mm.gif","name":"Myanmar","phone":"<a href='/mm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"na":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/na.gif","name":"Namibia","phone":"<a href='/na/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"np":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/np.gif","name":"Nepal","phone":"<a href='/np/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"nl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nl.gif","name":"Netherlands","phone":"<a href='/nl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"nc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nc.gif","name":"New Caledonia","phone":"<a href='/nc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":""},"nz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/nz.gif","name":"New Zealand (Aotearoa)","phone":"<a href='/nz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"ni":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ni.gif","name":"Nicaragua","phone":"<a href='/ni/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ne":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ne.gif","name":"Niger","phone":"<a href='/ne/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ng":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ng.gif","name":"Nigeria","phone":"<a href='/ng/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"no":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/no.gif","name":"Norway","phone":"<a href='/no/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"om":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/om.gif","name":"Oman","phone":"<a href='/om/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"pk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pk.gif","name":"Pakistan","phone":"<a href='/pk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":""},"ps":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ps.gif","name":"Palestine","phone":"<a href='/ps/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"pa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pa.gif","name":"Panamá","phone":"<a href='/pa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pg.gif","name":"Papua New Guinea","phone":"<a href='/pg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_AA"},"py":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/py.gif","name":"Paraguay","phone":"<a href='/py/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"pe":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pe.gif","name":"Perú","phone":"<a href='/pe/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"ph":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ph.gif","name":"Philippines","phone":"<a href='/ph/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"pl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pl.gif","name":"Poland","phone":"<a href='/pl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"pt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pt.gif","name":"Portugal","phone":"<a href='/pt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"pr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/pr.gif","name":"Puerto Rico","phone":"<a href='/pr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"qa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/qa.gif","name":"Qatar","phone":"<a href='/qa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"re":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/re.gif","name":"Reunion","phone":"<a href='/re/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ro":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ro.gif","name":"Romania","phone":"<a href='/ro/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ru":{"defaultLanguage":"ru","flag":"/shared-static/images/icons/flags/ru.gif","name":"Russia | Россия","phone":"<a href='/ru/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"rw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/rw.gif","name":"Rwanda","phone":"<a href='/rw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"gs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gs.gif","name":"S. Georgia and S. Sandwich Isls.","phone":"<a href='/gs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"kn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/kn.gif","name":"Saint Kitts and Nevis","phone":"<a href='/kn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"lc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lc.gif","name":"Saint Lucia","phone":"<a href='/lc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"vc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vc.gif","name":"Saint Vincent and the Grenadines","phone":"<a href='/vc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sm.gif","name":"San Marino","phone":"<a href='/sm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"st":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/st.gif","name":"Sao Tome and Principe","phone":"<a href='/st/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sa":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sa.gif","name":"Saudi Arabia","phone":"<a href='/sa/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sn.gif","name":"Senegal","phone":"<a href='/sn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"rs":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/rs.gif","name":"Serbia","phone":"<a href='/rs/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sc.gif","name":"Seychelles","phone":"<a href='/sc/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sl":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sl.gif","name":"Sierra Leone","phone":"<a href='/sl/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sg.gif","name":"Singapore","phone":"<a href='/sg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"http://myfisherstore.com/singapore/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SP"},"sk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sk.gif","name":"Slovak Republic","phone":"<a href='/sk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":" Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"si":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/si.gif","name":"Slovenia","phone":"<a href='/si/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"so":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/so.gif","name":"Somalia","phone":"<a href='/so/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"za":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/za.gif","name":"South Africa","phone":"<a href='/za/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"es":{"defaultLanguage":"es","flag":"/shared-static/images/icons/flags/es.gif","name":"Spain","phone":"<a href='/es/en/home/technical-resources/contact-us.html'>Contáctenos</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"lk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/lk.gif","name":"Sri Lanka","phone":"<a href='/lk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SA"},"sh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sh.gif","name":"St. Helena","phone":"<a href='/sh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sr.gif","name":"Suriname","phone":"<a href='/sr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"sj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sj.gif","name":"Svalbard and Jan Mayen Islands","phone":"<a href='/sj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"sz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sz.gif","name":"Swaziland","phone":"<a href='/sz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"se":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/se.gif","name":"Sweden","phone":"<a href='/se/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"ch":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ch.gif","name":"Switzerland","phone":"<a href='/ch/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"sy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/sy.gif","name":"Syria","phone":"<a href='/sy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tw":{"defaultLanguage":"zt","name":"Taiwan | 台灣","phone":"<a href='/tw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_TW"},"tj":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tj.gif","name":"Tajikistan","phone":"<a href='/tj/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tz.gif","name":"Tanzania","phone":"<a href='/tz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"th":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/th.gif","name":"Thailand","phone":"<a href='/th/en/home/technical-resources/contact-us.html?supportType=OS#ordersupport'>Order Support</a>","signInHidden":true,"registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"tg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tg.gif","name":"Togo","phone":"<a href='/tg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"to":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/to.gif","name":"Tonga","phone":"<a href='/to/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"IPAC_AA"},"tt":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tt.gif","name":"Trinidad and Tobago","phone":"<a href='/tt/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"tn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tn.gif","name":"Tunisia","phone":"<a href='/tn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tr":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tr.gif","name":"Turkey","phone":"<a href='/tr/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tm.gif","name":"Turkmenistan","phone":"<a href='/tm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"tc":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/tc.gif","name":"Turks and Caicos Islands","phone":"<a href='/tc/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ug":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ug.gif","name":"Uganda","phone":"<a href='/ug/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ua":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ua.gif","name":"Ukraine","phone":"<a href='/ua/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ae":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ae.gif","name":"United Arab Emirates","phone":"<a href='/ae/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"uk":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/gb.gif","name":"United Kingdom","phone":"<a href='/uk/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"quickLinkIndex":"6","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"https://eu.fishersci.com/eu/","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"EMEA"},"us":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/us.gif","name":"United States","signInHidden":"","registerHidden":"","euCountry":"","quickLinkIndex":"7","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar3.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"//www.unitylabservices.com","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"NA"},"um":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/um.gif","name":"United States Minor Outlying Islands","phone":"<a href='/um/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":true,"registerHidden":true,"euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"uy":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/uy.gif","name":"Uruguay","phone":"<a href='/uy/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"uz":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/uz.gif","name":"Uzbekistan","phone":"<a href='/uz/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"va":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/va.gif","name":"Vatican City State (Holy See)","phone":"<a href='/va/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ve":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ve.gif","name":"Venezuela","phone":"<a href='/ve/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"vn":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vn.gif","name":"Vietnam","phone":"<a href='/vn/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"2","groupDisplay":"","regionMapping":"IPAC_SEA"},"vg":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vg.gif","name":"Virgin Islands (British)","phone":"<a href='/vg/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"vi":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/vi.gif","name":"Virgin Islands (U.S.)","phone":"<a href='/vi/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":"","regionMapping":"LATAM_Others"},"eh":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/eh.gif","name":"Western Sahara","phone":"<a href='/eh/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":true,"brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"ye":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/ye.gif","name":"Yemen","phone":"<a href='/ye/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"zm":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/zm.gif","name":"Zambia","phone":"<a href='/zm/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""},"zw":{"defaultLanguage":"en","flag":"/shared-static/images/icons/flags/zw.gif","name":"Zimbabwe","phone":"<a href='/zw/en/home/technical-resources/contact-us.html'>Contact Us</a>","signInHidden":"","registerHidden":"","euCountry":"","brandsImagePath":"/content/dam/LifeTech/Images/Header/brandbar.png","isGlobal":false,"brand1linkText":"Thermo Scientific","brand1linkURL":"/us/en/home/brands/thermo-scientific.html","brand2linkText":"Applied Biosystems","brand2linkURL":"/us/en/home/brands/applied-biosystems.html","brand3linkText":"Invitrogen","brand3linkURL":"/us/en/home/brands/invitrogen.html","brand4linkText":"Fisher Scientific","brand4linkURL":"//www.fishersci.com","brand4openLinkInNewWindow":true,"brand5linkText":"Unity Lab Services","brand5linkURL":"http://www.unitylabservices.com/","brand5openLinkInNewWindow":true,"brandGroup":"1","groupDisplay":""}}; </script> <script type="text/javascript" src="/store/global-header-footer-static/tf/js/footer-base.min.468bd07150dbbf.js" async></script> <script id="minicartScript" src="/store/minicartv3/minicart.js"></script> <script id="identityGlobal" src="/account-center/scripts/identityGlobal.min.js"></script>  <script data-inline-file-name='sec-assets-redirect.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/sec-assets-redirect.min.js */ !function(e){let t=document.querySelectorAll("a[href^='https://sec-assets']");for(var n=0;n<t.length;n++)t[n].setAttribute("target","_blank"),t[n].addEventListener("click",function(t){t.preventDefault(),o(t,e(this))});function o(t,n){storageAssets=function(){var e,t,n,o=[],a={},s=0,i=document.getElementsByTagName("body")[0];function l(){if(0===s){if(!window.environmentURL)return!1;e="https://"+window.location.host,(t=!0)?(s=1,r()):(s=5,(n=document.createElement("iframe")).src=e+"/shared-static/support/_lt.localStorage.html",n.style.display="none",n.onload=function(){s=1,r()},n.onerror=function(){s=9},i.appendChild(n),window.attachEvent?window.attachEvent("message",d):window.addEventListener("message",d,!1))}}function d(e){if(e&&e.data&&"string"==typeof e.data){var t=e.data.split(":"),n=e.origin,o=decodeURIComponent(t[0]),s=decodeURIComponent(t[1]),i=(decodeURIComponent(t[2]),decodeURIComponent(t[3]));-1!==n.indexOf("thermofisher.")&&c(i,a[o+":"+s])}}function c(e,t){e?"lsFailure"===e&&(e=!1):e=null,t&&t(e)}function r(){for(var e,t=0;t<o.length;t++)u((e=o[t]).action,e.key,e.value,e.callback)}function u(i,d,r,u){if(l(),1!==s)o.push({action:i,key:d,value:r,callback:u});else if(t){var m=null;try{m=d&&r?window.localStorage[i](d,r):d?window.localStorage[i](d):window.localStorage[i]()}catch(e){m="lsFailure"}c(m,u)}else{var g="ls-"+i+":"+Math.floor(1e6*Math.random()+1),p=g;d&&(p+=":"+encodeURIComponent(d),r&&(p+=":"+encodeURIComponent(r))),a[g]=u,n.contentWindow.postMessage(p,e)}}return{getItem:function(e,t){u("getItem",e,null,t)},setItem:function(e,t,n){u("setItem",e,t,n)}}}();var o,a,s=window.location.hostname,i="/"+_lt.user.displayIso+"/"+_lt.user.displayLang+"/syndicated-content/snippets/terms-secure-file.html",l=s.split("thermofisher.")[1],d="https://"+s+"/api-gateway/tfdocs/signedurl?objectKey="+n.attr("href").split(l+"/")[1],c=localizedStrings.ACCEPTANCE||"Acceptance to Terms of Use",r=localizedStrings.BTN_AGREE||"Agree",u=localizedStrings.BTN_DISAGREE||"Disagree",m=localizedStrings.SUBMIT_ERROR_SERVER||"Error - please try again.";storageAssets.getItem("secureFileAccepted",function(n){if(_lt.user.isLoggedIn)if(e.ajax({type:"GET",url:d,dataType:"text",cache:!1,async:!1,success:function(e){try{o=JSON.parse(e)}catch(e){console.log("Error in Parsing Json File")}},error:function(e,t,n){},complete:function(){null!=o&&void 0!==o?a=o.success.preSignedURL:console.log("Error in getting presigned URL")}}),null!=n&&"Y"==n)window.open(a,"_blank"),_lt.user.initLoginChecks();else{var s=e('<div class="modal hide modal-loading modal-secure-file-acceptance"><div class="modal-header"><button type="button" class="close" data-dismiss="modal" aria-hidden="true">×</button><h3>'+c+'</h3></div><div class="modal-body"><div class="text-center"><span class="loading-wheel loading-wheel-md"></span></div></div><div class="modal-footer"><button type="button" class="btn btn-disagree" data-dismiss="modal">'+u+'</button><a href="'+a+'" target="_blank" class="btn btn-primary btn-agree">'+r+"</a></div></div>"),l=e(".modal-body",s);e(".btn-disagree",s),e(".btn-agree",s).click(function(){storageAssets.setItem("secureFileAccepted","Y"),s.modal("hide"),s.remove(),_lt.user.initLoginChecks()}),s.on("hidden",function(){s.remove()}),e.get(i).success(function(e){l.html(e),s.removeClass("modal-loading")}).error(function(e){l.text(m)}),s.appendTo("body"),s.modal({backdrop:"static",keyboard:!1}),s.modal("show"),e("body").append("<style>.modal-secure-file-acceptance.modal-loading .modal-footer { display:none; }</style>"),t.stopImmediatePropagation()}else invokeOidcLogin(window.location.href)})}}(window.$j);</script> <script type="text/javascript" id="dmOffers" src="/dm-offers/offers.min.js" defer></script> <script type="text/javascript"> var preferences = document.cookie.match(new RegExp("(^| )notice_preferences=([^;]+)")); var deployLaunch = ((preferences && parseInt(preferences[2] || 0) > 0) || (!true && !window.location.href.includes("eta=true"))); if (!document.querySelector("#tagmanager") && deployLaunch && !(/how-cookies-are-used|privacy-policy/i.test(window.location.href))) { var script = document.createElement("script"); script.id = "tagmanager"; script.src = "https://assets.adobedtm.com/launch-ENeecb77f1160a4928a492ff040f7110c7.min.js"; script.type = "text/javascript"; document.head.appendChild(script); } else { var script = document.createElement("script"); script.src = "https://assets.adobedtm.com/7e08552ade3f/1a8047d2b483/launch-f46125d37e44.min.js"; script.type = "text/javascript"; document.head.appendChild(script); } </script>  <script data-inline-file-name='digitalDataAnalyticsListener.min.js' data-inline-site='tf'>/* Hash: 468bd07150dbbf Source: /tf/js/dist/digitalDataAnalyticsListener.min.js */ !function(){"use strict";window.digitalDataAnalyticsListener={initted:!1,init:function(){this.emailCampaignRecord()},emailCampaignRecordFired:!1,emailCampaignRecord:function(){if(0!=digitalData.merchandisingDataInitted)if(1!=this.emailCampaignRecordFired){var i=digitalData.merchandising,a=i.emid;void 0!==a&&null!=a&&""!=a?(console.log("digitalDataAnalyticsListener: Email campaign tracking recored about to fire"),$.ajax({headers:{"Content-Type":"application/json; charset=utf-8"},url:environmentURL.DATAHUB+"/datahub/api/v1/datalayer/record",dataType:"json",type:"POST",contentType:"application/json",data:JSON.stringify({hit_domain:window.location.hostname,referrer:i.referrer,analyticsVisitorid:i.analyticsVisitorID,marketingCloudid:i.marketingCloudVisitorID,dmOfferSessionid:i.sessionId,s_vi_low:i.s_vi_low,s_vi_high:i.s_vi_high,icid:i.icid,cid:i.cid,emid:i.emid,amoid:i.amoid,formid:digitalData.form,gigya_uid:digitalData.user.gigyaId}),success:function(i){console.log("digitalDataAnalyticsListener: Success",i),digitalDataAnalyticsListener.emailCampaignRecordFired=!0},error:function(i){console.log("digitalDataAnalyticsListener: Data not persisted",i),digitalDataAnalyticsListener.emailCampaignRecordFired=!1}})):console.log("digitalDataAnalyticsListener: Email campaign tracking NOT triggered as emid is not present")}else console.log("digitalDataAnalyticsListener: Email campaign record was successfully fired once before");else console.log("digitalDataAnalyticsListener: Not ready to fire email campaing record")}}}(),window.digitalDataAnalyticsListener.init();</script> <script id="chatLauncher" src="//chat-api.thermofisher.com/search/chat-launcher/chat-launcher.js" defer></script>  <div id="landscape-banner"> <div class="interactoffers"> <div class="dynamic-offer" id="tf-headerfooter-lb" data-placement-type="headerfooter" data-placement-code="lb" data-default-snippet=""> </div> </div> </div> </div> </footer> </div> <form id="productForm" name="productForm" method="POST"></form>  <form action="&CID=&ICID=" method="POST" id="IVGNaddToCartForm"> <input id="IVGNAddToCartXML" name="AddToCartXML" type="hidden" value="" /> </form> <iframe style="display:none;" id="addToFavoritesTarget">AddToFavs result goes here(DO NOT DELETE ME!)</iframe> <div id="pop-add" class="mag-dialog on-top" style="display: none;"> <div class="dialog-content" style="padding-bottom: 20px;"> <button class="close pop-add-cls" type="button">Close X</button> <h3 style="margin-bottom: 0px;"> Your item<span id="pop-plural" style="display: none; float: none;">s have</span><span id="pop-sing" style="float: none;"> has</span> been added! </h3> <br /> <input type="button" class="pop-b button primary-button core-view" value="View Cart" /> <input type="button" class="button commerce-button checkout pop pop-b core-checkout" value="Checkout" /> </div> </div>  <script> var _savedJQuery = window.$; window.jQuery = window.$j; </script> <script> window.$ = _savedJQuery; window.jQuery = _savedJQuery; </script> <script> $m.assayType = ''; </script>  <div style="display:none" id="debugMessage"> Host server : magellan-search-blue-5c9c5c4749-ffltp:80/100.66.78.226:80. <br>git-commit: d22414ba47b22cc02ffc24003f0e179da61511a6 <br>git-url: https://github.com/thermofisher/magellan-search <br>git-branch: release/2.21.0-Offline </div> <script> $m.translations = {"antibody.serp.filter.ptm":"PTM","antibody.serp.footer.talk":"Talk to a specialist now","immunoassay.elisa.zero.results.reason.one":"Spelling or typing errors. You can use the product search to modify your search.","antibody.pdp.documents":"Documents","antibody.pdp.productDetail.conjugate":"Conjugate","common.search.modal.faq.heading.success":"Thank you for your feedback","microbe.zero.results.reason":"Possible reasons that no Assays were found:","global.search.results.faqCard.feedback":"Provide Feedback on this Answer","global.search.secondaryResults.navigators.manualsAndProtocols.nav1":"Document Types","antibody.zero.results.other.subtype.two":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}query/{0}\"\u003e{2} {3}\u003c/a\u003e and \u003ca href\u003d\"{4}query/{0}\"\u003e{5} {6}\u003c/a\u003e that match your search.","global.search.results.cmgtProdCard.specifications":"General Specifications","antibody.pdp.reference.zeroResultBtnTxt":"Cite this product","antibody.pdp.productDetail.elisa":"ELISA","common.wsp.tooltip.info":"Web orders only. Excludes Supply Centers.","global.search.filter.persona.allResults":"All Results","common.search.modal.search.heading":"What were you looking for?","antibody.pdp.reference.benchscilink":"View published figure on \u003cimg class\u003d\"benchsci-logo\" src\u003d\"/order/genome-database/assets/img/benchsci-logo.svg\"\u003e\u003cimg src\u003d\"/content/dam/LifeTech/Images/Header/jumpout-link.png\"\u003e","crispr.zero.results.contact":"GEMServices@thermofisher.com","global.search.results.genomicsHelperCard.productType":"Product Type","antibody.pdp.hero.viewOther.proteinFamilyPageExist":"View all {0} {1}s","elisa.sitemap.description":"ELISA (enzyme-linked immunosorbent assay) is a plate-based technique for detection and quantification of antibodies or proteins such as cytokines, chemokines, growth factors, hormones, and intracellular phosphorylated proteins.","global.search.results.probesStructureCard.casNameAndNumber":"CAS Name/Number","global.search.results.geneCard.entrezGeneID":"Entrez Gene ID","antibody.searchresults.rowheader.host":"Host","elisa.crossSellCard.select.antibody.forKit":"Select Antibodies for your kit","global.search.noResults.resources.requestMsds":"Request an MSDS","antibody.pdp.productDetail.cytotoxicityassay":"Cytotoxicity Assay","antibody.pdp.bioinformatics.proteinAliases":"Protein Aliases:","global.search.qty.invalid":"Please enter a quantity in the range of 1 to 9999.","global.search.results.faqCard.answerId":"Answer Id: {0}","serp.nav.tabs.isotype.controls":"Isotype Controls","global.search.results.handbookCard.resultType":"Molecular Probes Handbook","antibody.pdp.reference.less":"less ","elisa.pdp.hero.reference":" Reference","elisa.crossSellCard.find.exact.antibody":"Find the exact antibody for your Elisa kit.","global.search.results.probesStructureCard.resultType":"Chemical Structure","elisa.sitemap.titleprefix":"ELISA Kits","elisa.pdp.productdetails.speciesreported":"Species (reported)","serp.filter.lessText":"Less","elisa.searchresults.rowheader.timetoresult":"Time To Result","antibody.serp.compare.storage.conditions":"Storage Conditions","global.search.results.cmgtProdCard.supportDocuments":"Support Docs","global.search.button.configure":"Configure","serp.filtertext.displayname.species":"Species","global.search.noResults.needHelp.contactUs":"Contact Us","antibody.pdp.productDetail.chipassay":"ChIP assay","global.search.results.mediaFormulationCard.catNo":"Catalog #s","antibody.searchresults.rowheader.product":"Product","antibody.serp.compare.class.type":"Class / Type","antibody.searchresults.sop.save":"Save","global.search.results.probesStructureCard.viewMoreComponents":"View More","antibody.serp.compare.reference":"Reference","oligos.jpOligos.bulkUpload.uploadOptionsHeader":"Select the default options below to apply to your imported sequences.","antibody.tfp.desc.viewmore":"View more","antibody.pdp.productDetail.fluorescenceresonanceenergytransfer":"Fluorescence Resonance Energy Transfer ","info.tout.footer.createTxt":"Create","immunoassay.elisa.zero.results.other":"However, we found \u003ca href\u003d\"{0}\"\u003e{1} other\u003c/a\u003e results on the site","antibody.pdp.productDetail.westernblot":"Western Blot","global.search.noResults.heading":"No Results","global.search.results.vectorCard.resultType":"Vector Map","antibody.pdp.productDetail.readytouseimmunoassay":"Ready-To-Use Immunoassay","elisa.pdp.productdetails.genesymbol":"Gene symbol","global.search.results.geneCard.species":"Species","antibody.pdp.reference.mostrecent":"Most recent ","global.search.noResults.querySuggestionWithResults":"Search for: \"\u003ca href\u003d\"{0}\"\u003e{1}\u003c/a\u003e\" ({2} matches)","oligos.jpOligos.bulkUpload.pasteSequence":"Copy/Paste Upload","info.modal.header.sharedListdescmobile":"Shared lists are a new way to save products. Create \n a list for each of your projects to share with \n collaborators like your lab manager. Then \n select and buy products as a team. ","antibody.searchresults.row.with.numeric.figure":" figure","elisa.pdp.productdetails.productsize":"Product size","global.search.results.cmgtProdCard.price":"List Price","antibody.pdp.productDetail.immunogen":"Immunogen ","global.search.sharedList.addedTo":"Added to","serp.filtertext.displayname.host":"Host","crispr.searchresults.rowheader.species":"Species","antibody.pdp.productDetail.storagebuffer":"Storage buffer","global.search.button.saveToList":"Save to list","oligos.jpOligos.addOligo.delivery":"Delivery *","info.modal.header.sharedListdesc":"Shared lists are a new way to save products. Create a list for each of your projects to share \n with collaborators like your lab manager. Then select and buy products as a team.","global.search.results.citationCard.productUsage":"Product Usage","antigen.onboarding.message":"Adjust the sliders to select your desired sequence range","antibody.pdp.productDetail.Viewimmunogen":"View immunogen","common.search.modal.search.button.submit":"submit","info.modal.header.createsharedListDesc":"Click \"Save to list\" to create your first list, \n give it a name, and add the product. Access \n your shared lists in the Account link on \n Thermofisher.com. ","global.search.results.featuredResultCard.resultType":"Overview","support.search.techSupport.navigation.productFaqs":"Product FAQs","antibody.pdp.bioinformatics.uniProtID":"UniProt ID:","global.search.results.probesStructureCard.molWeight":"Molecular Weight","proteinnpeptide.sitemap.titleprefix":"Proteins \u0026 Peptides","antibody.searchresults.row.bestseller":"Best Seller","proteinnpeptide.sitemap.description":"Wide range of recombinant proteins, native proteins, and synthetic peptides for cell culture, functional studies and other immunoassays. Select a target to view all proteins.","oligos.jpOligos.bulkUpload.processingWait":"We are processing your request. This may take a few moments. Thank you for your patience.","antibody.searchresults.row.mobile.continue":"Continue","antibody.pdp.productDetail.immunohistochemistrypfafixed":"Immunohistochemistry (PFA fixed)","common.search.modal.faq.button.cancel":"cancel","support.search.techSupport.navigation.orderingAndWebFaqs":"Ordering \u0026amp; Web FAQs","common.search.modal.search.validation.required.feedback":"Please provide feedback","antibody.serp.spellcheck.singleSearchTextKeywordSingular":"\u003cspan class\u003d\"regWeight\"\u003eNo result for\u003c/span\u003e \u003cstrong\u003e{1}\u003c/strong\u003e. \u003cspan class\u003d\"regWeight\"\u003eShowing \u003cstrong\u003e{0} results\u003c/strong\u003e for\u003c/span\u003e {2}","antibody.pdp.footer.helpText":"Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.","antibody.pdp.productDetail.flowcytometry":"Flow Cytometry","global.search.results.genericContentCard.heading":"Buying Guide","serp.flt.srch.placeholder.brand":"Search Brand","serp.flt.srch.placeholder.conjugate":"Search Conjugate","antibody.tfp.subheader.targetinformation":"Target Information","support.search.techSupport.navigation.technicalReferenceLibrary":"Technical Reference Library","global.search.results.cmgtProdCard.numCitations":"View \u003cb\u003e{0}\u003c/b\u003e Citations ","antibody.pdp.productDetail.clone":"Clone","antibody.pdp.productDetail.form":"Form","global.search.noResults.additionalResource.content":"Looking for a \u003ca href\u003d\"/site/us/en/home/support/Certificate-of-Analysis-Request-Form.html\"\u003eCertificate of Analysis\u003c/a\u003e or a \u003ca href\u003d\"/site/us/en/home/support/MSDS-Request-Form.html\"\u003eMSDS\u003c/a\u003e?","global.search.results.msdsCard.resultType":"MSDS","oligos.jpOligos.messages.noProjects":"Please add one or more projects","antibody.pdp.commerceCard.dateTooltipMessage":"Items usually ship within 1 business day from the estimated availability date.","serp.filtertext.displayname.crossadsorbed":"Cross Adsorbed","antibody.pdp.productDetail.antibodiesbyimmunogen":"antibodies by immunogen","antibody.pdp.productDetail.affinitypurification":"Affinity Purification","antibody.pdp.productDetail.immunostaining":"Immunostaining","antibody.searchresults.row.mostfigures":"Most Figures","antibody.pdp.productDetail.inhibitionassays":"Inhibition Assays","antibody.searchresults.row.account.price.tooltip":"Your account price is the best price.","global.search.noResults.searchTips.heading":"Search Tips:","antibody.searchresults.row.mobile.select":"Select","unified.card.mirna":"miRNA mimics and inhibitors","oligos.jpOligos.addOligo.modificationsAndOptions":"Modifications and options","antibody.searchresults.row.mobile.done":"Done","global.button.sharedList.createTxt":"Create","antibody.pdp.hero.proteins.viewOther":"View all ({0}) {1} proteins","antibody.searchresults.tabheader.products":"Products","antibody.pdp.productDetail.expressionSystem":"Expression System","elisa.pdp.productdesc.have.you.cited.this.product":"Have you cited this product in a publication? ","antigen.searchresults.nosearchresults":"No search results","global.search.results.minipdp.manuls.heading":"Manuals \u0026 Product Inserts ","support.search.searchTips":"Search Tips","antibody.pdp.productDetail.activity":"Activity","serp.tabheader.searchby":"Search by","antibody.pdp.productDetail.blockingassay":"Blocking Assay","crispr.zero.results.contact.assistance":"for assistance.","antibody.pdp.productDetail.dotblot":"Dot blot","antibody.pdp.reference.citation":"citation","global.search.results.vectorCard.map":"Map","support.search.noResults.heading":"No Results","antibody.pdp.hero.dataSheets":"Datasheet","antibody.pdp.commerceCard.checkYourPrice":"Check your price","antibody.searchresults.row.guest.user.tooltip":"now to see your best price.","global.search.results.probesStructureCard.molFormula":"Molecular Formula","microbe.zero.results":"No results found","antigen.searchresults.rowheader.sequenceRange":"Sequence Range","antibody.pdp.productDetail.endotoxinconcentration":"Endotoxin concentration","serp.filtertext.displayname.new":"New","serp.filtertext.displayname.format":"Format","oligos.jpOligos.addOligo.baseCount":"Base Count","antibody.pdp.productDetail.species":"Species","antibody.searchresults.row.online.offer":"Online offer: ","oligos.jpOligos.addOligo.reverseComplementOligoName":"Reverse Complement Oligo Name *","antibody.pdp.productDetail.radioimmuneassays":"Radioimmune Assays","serp.panel.builder.adText.tryPB":"Try Panel Builder","global.search.results.itemsPerPage":"Results per page","antibody.pdp.imageGallery.dataGallery":"Data Gallery","antibody.pdp.reference.year":"Year","antibody.pdp.hero.viewOther":"View all ({0}) {1} antibodies","antibody.pdp.bioinformatics.entrezGeneID":"Entrez Gene ID:","antibody.pdp.productDetail.testedApplication":"Applications","global.search.results.assayCard.assayId":"Assay ID","antibody.searchresults.row.mobile.filter.results":"Filter results","antibody.pdp.productDetail.chipsequencing":"ChIP-sequencing","support.search.techSupport.navigation.allSupportDocs":"MSDS, COA \u0026amp; other Support Documents","antibody.serp.compare.references":"s","antibody.serp.filter.protein.name":"Protein Name","antibody.pdp.commerceCard.pdlt.2-4weeks":"2-4 Weeks","zrp.no.results":"No results for \"{0}\" in {1}","global.search.noResults.needHelp.detailedSearchTips":"Detailed Search Tips","antigen.searchresults.rangeText":"Select your sequence range","serp.flt.srch.placeholder.proteintarget":"Search Protein Target","serp.filtertext.displayname.proteintarget":"Protein Target","antigen.searchresults.resetsearchbtn":"Reset search","antibody.searchresults.rowheader.offer.ends":"Offer ends ","antibody.pdp.bioinformatics.processes":"Process(es)","antibody.pdp.footer.helpTitle":"We\u0027\u0027\u0027re here to help","antibody.pdp.productDetail.neutralization":"Neutralization","antibody.pdp.productDetail.tcellactivation":"T-Cell Activation","global.search.results.cmgtProdCard.productApplications.label":"Product Applications","antibody.serp.compare.antibody.form":"Antibody Form","antibody.pdp.productDetail.immunofluorescence":"Immunofluorescence ","global.search.results.dayCard.heading":"Learn more about","antibody.comparepage.compare":"Compare","global.search.results.msdsCard.msdsFiles":"MSDS Files","global.search.results.assayCard.productType":"Product Type","support.search.navigator.documentType.label.lull":"Limited Use Label Licenses","support.search.placeholder.tip.msds":"by catalog number or product name","antibody.serp.compare.concentration":"Concentration","unified.card.proteins":"Recombinant proteins and peptides","support.search.techSupport.navigation.contactOrderSupport":"Contact Order Support","crispr.zero.results.reason.two":"The products are listed under an alternate gene name. Try using Entrez Gene ID or a synonym as an identifier.","antibody.pdp.bioinformatics.header":"Bioinformatics","antibody.searchresults.row.advanced.verification":"Advanced Verification","antibody.pdp.productDetail.purification":"Purification","support.search.placeholder.tip.citationsAndReferences":"by catalog number or keyword","antibody.pdp.productDetail.immunoradiometricassay":"Immunoradiometric Assay","antibody.searchresults.rowheader.price.symbol":"CNY","elisa.pdp.productdetails.analyticalsensitivity":"Analytical sensitivity","support.search.navigator.documentType.label.all":"All Support Documents","antibody.pdp.productDetail.immunodiffusion":"Immunodiffusion","antibody.searchresults.row.load.more.results":"Load {0} more results","support.search.results.found":"[{0} matches]","antibody.searchresults.row.special.offer":"Special offer: ","antibody.serp.compare.target":"Target","support.search.placeholder.tip.mediaFormulations":"by catalog number","global.search.pagination.nextPage":"Next \u0026gt;","elisa.pdp.showLess.button":"Show Less","common.search.modal.faq.label.expectations.exceeded":"Exceeded","elisa.serp.createOwn.section":"Create Your Own ELISA","global.search.results.lullCard.lullFiles":"Limited Use Label Licenses","serp.loadmore.viewText":"Viewing {0} {1} {2}","oligos.jpOligos.addOligo.scale":"Synthesis Scale *","global.search.form.searchWithin.message":"Search Within","antibody.pdp.commerceCard.offerends":"Offer ends","global.search.error.heading":"An error occurred during search.","antibody.serp.filter.showLess.filters":"Show Less","antibody.pdp.reference.citations":"citations","common.search.modal.faq.validation.invalid.email":"Please enter a valid email address","antibody.serp.compare.cross.adsorption":"Cross Adsorption ","antibody.serp.compare.immunogen":"Immunogen","oligos.jpOligos.bulkUpload.templateDownloadButton":"Download Sequence Template","antibody.sitemap.primary.titleprefix":"Primary Antibodies","antibody.searchresults.row.best.price.tooltip":"This is your best price.","common.search.modal.faq.label.body":"Feedback on FAQ:","global.search.noResults.additionalResource.heading":"Additional Resources:","global.search.results.geneCard.resultType":"Gene","support.search.navigator.documentType.label.brochures":"Product Literature","antibody.pdp.reference.see":"See","microbe.zero.results.contact.three":"for direct assistance. In most cases, our service desk will respond within 1 business day.","global.search.sortingOptions.dateSort.descending":"Newest First","antibody.pdp.productDetail.contains":"Contains","global.search.enterListName.watermark":"Enter list name","oligos.jpOligos.messages.emptyProject":"One or more projects do not contain any oligos","antibody.searchresults.row.cat":"Cat #","support.search.navigator.documentType.label.coa":"Certificates of Analysis","elisa.pdp.productdetails.labelordye":"Label or dye","oligos.jpOligos.common.buttons.newProject":"New Project","antibody.searchresults.row.special.price.tooltip":"Special offer is your best price.","serp.filtertext.displayname.conjugate":"Conjugate","antibody.serp.filter.brand":"Brand","global.search.results.manualCard.catNo":"Cat. No.","antibody.pdp.productDetail.aminoacidsequence":"Amino acid sequence","antibody.searchresults.row.online.price":"Online price: ","serp.flt.srch.placeholder.cellline":"Search Cell Line","serp.nav.tabs.proteins.peptides":"Proteins and Peptides","antibody.comparepage.print":"Print","global.search.results.posterCard.resultType":"Scientific Poster","antibody.pdp.productDetail.purity":"Purity","antibody.pdp.commerceCard.contactus":"Contact Us","antibody.pdp.productDetail.relativeexpression":"Relative expression","elisa.pdp.productdetails.timetoresult":"Time-to-result","global.search.results.manualCard.resultType":"Manual / Product Insert","global.search.results.protocolCard.resultType":"Experiment Protocol","antibody.zero.results.other":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}\"\u003e{2} other results\u003c/a\u003e on the site.","global.search.noResults.resources.requestCoa":"Request a Certificate of Analysis","global.search.results.citationCard.id":"ID","antibody.pdp.commerceCard.pdlt.1-2weeks":"1-2 Weeks","support.search.form.searcharea.refine.label":"Refine your search","global.search.error.body":"Please review your keyword and try again.","antibody.pdp.productDetail.immunomicroscopy":"Immunomicroscopy","support.search.placeholder.tip.vectors":"by catalog number or product name","crispr.zero.results.reason":"Possible reasons that no CRISPR Guide RNA were found:","unified.card.isotype":"Isotype controls","serp.flt.srch.placeholder.clone":"Search Clone","antibody.serp.filter.antibody.form":"Antibody Form","global.search.button.quickProductInfo":"Quick Product Info","common.search.modal.faq.validation.required.feedback":"Please provide feedback","antibody.pdp.commerceCard.quantity":"Quantity","antibody.pdp.productDetail.storageconditions":"Storage conditions","antibody.serp.compare.clone":"Clone","crispr.searchresults.rowheader.assayId":"Assay ID","global.search.results.manualCard.download":"Download","oligos.jpOligos.bulkUpload.fileUpload":"DNA File Upload","elisa.pdp.productdetails.proteinfamily":"Protein family","antibody.pdp.hero.references":"{0} Reference{1}","antibody.pdp.productDetail.peptidearray":"Peptide Array","antibody.pdp.imageGallery.benchsciImageText":"View full figure on","common.search.modal.faq.label.expectations.notMet":"Not Met","global.search.results.genomicsHelperCard.resultType.mirna":"miRNA Mimic, Inhibitor and Assay","antibody.serp.compare.conjugate":"Conjugate","global.search.noResults.resources.heading":"Resources","oligos.jpOligos.addProject.addOligo":"Add Oligo","antibody.pdp.productDetail.crossadsorption":"Cross Adsorption","unified.card.antibody":"Antibodies","antibody.serp.singleSearchText":"{0} results","unified.card.taqman":"TaqMan™ assays and arrays","info.modal.header.learnMoresharedList":"Learn More","global.search.results.dayCard.resultType":"Overview","oligos.jpOligos.basicEntry.help":"Help","antibody.pdp.footer.helpButton":"Contact tech support","global.search.results.brochureCard.version":"Version","elisa.searchresults.rowheader.sensitivity":"Sensitivity","antibody.pdp.commerceCard.pendingTooltipChinaSCMessage":"We can\u0027t get availability information for you right now. Items usually ship with the next Supply Center shipment.","crispr.searchresults.rowheader.price":"Price (USD)","oligos.jpOligos.bulkUpload.invalidFileFormat":"Invalid file type - please save file as .xls, .csv or .txt and upload again.","elisa.pdp.productdetails.assaykitformat":"Assay kit format","support.search.placeholder.tip.spectra":"by catalog number","global.search.results.genericContentCard.resultType":"Buying Guide","serp.filtertext.displayname.producttype":"Product Type","antibody.pdp.productDetail.antibodyform":"Antibody Form","antibody.pdp.commerceCard.availability.text":"Estimated availability date: ","global.search.results.faqCard.answer":"Answer","antibody.pdp.productDetail.immunoprecipitation":"Immunoprecipitation","antibody.comparepage.addtocart":"Add to cart","antibody.pdp.productDetail.Viewall":"View all","antibody.serp.comapre.not.in.region":"Product not available in your region","antibody.pdp.reference.authors":"Authors","antibody.pdp.productDetail.targetInformation":"Target Information","oligos.jpOligos.common.buttons.import":"Import","common.search.modal.search.validation.invalid.email":"Please enter a valid email address","microbe.zero.results.contact.one":"Please contact","antibody.serp.filter.protein.target":"Protein Target","microbe.zero.results.reason.two":"The assay is listed under an alternate gene/protein name. Try searching for synonyms.","unified.card.secondary":"Secondary antibodies","global.search.results.featuredResultCard.heading":"Featured Product","antibody.pdp.hero.publishedFigures":"{0} Published Figure{1}","antibody.pdp.productDetail.forresearchuseonlynotforuseindiagnosticproceduresnotforresalewithoutexpressauthorization":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","info.modal.header.collaboratesharedListHeader":"Collaborate","antibody.searchresults.row.reference":" Reference","global.search.results.cmgtProdCard.contactUs.Url":"http://template.day.fqdn/site/us/en/home/Global/Contact-Us.html","global.search.noResults.searchTips.list":"\u003cli\u003eRe-check spelling of search word(s).\u003c/li\u003e\u003cli\u003eSearch with fewer words. For example, instead of searching for \"Countess Automated Cell Counter\", try searching for \"Countess\".\u003c/li\u003e\u003cli\u003eRemove any special characters from catalog numbers. For example, instead of searching for \"XYZ-123\", try searching for \"XYZ123\".\u003c/li\u003e","oligos.jpOligos.addProject.researcherName":"Researcher Name *","antibody.pdp.commerceCard.performanceGuarantee":"Performance Guarantee","oligos.jpOligos.basicEntry.mainHeading":"Custom DNA Oligos","antibody.searchresults.rowheader.clearall":"Clear all","antibody.pdp.imageGallery.validationinfo":"validation info.","global.search.sortingOptions.dateSort.ascending":"Oldest First","antibody.serp.filter.product.type":"Product Type","microbe.zero.results.reason.three":"Spelling or typing errors. You can use the search above to modify your search,","global.search.results.cmgtProdCard.ratings.heading":"User Ratings","global.search.results.cmgtProdCard.seeAll":"See all","antibody.pdp.productDetail.immunohistochemistryfrozen":"Immunohistochemistry (Frozen)","elisa.pdp.productdetails.genealiases":"Gene aliases","antibody.searchresults.sop.price":"Price","crispr.searchresults.rowheader.gene":"Gene","antibody.searchresults.row.sop.online.price":"Online exclusive","antibody.pdp.reference.species":"Species","elisa.pdp.hero.about.this.kit.rigorousvalidation":"Rigorous validation","antibody.pdp.productDetail.publishedSpecies":"Published species","antibody.searchresults.row.with.numeric.figures":" figures","elisa.crossSellCard.customAssay.service":"Custom Assay Services","antibody.serp.footer.desc1":"Searching for an antibody we don\u0027\u0027t offer? We make custom antibodies for specific targets, species and applications.","antibody.serp.footer.desc2":"More than 18,000 custom antibodies created so far.","global.search.results.lullCard.resultType":"Limited Use Label License","oligos.jpOligos.deleteOligo.title":"Confirmation","antibody.pdp.productDetail.rrid":"RRID","antibody.pdp.productDetail.competitionassay":"Competition Assay","antibody.pdp.productDetail.agglutination":"Agglutination","common.search.modal.faq.label.expectations":"Expectations:","serp.filtertext.displayname.tag":"Tag","global.search.noResults.resources.realTimePCRCatalog":"Looking for TaqMan\u0026reg; Assay or Silencer\u0026reg; siRNA products? View our \u003ca href\u003d\"http://template.day.fqdn/site/us/en/home/Products-and-Services/Applications/Nucleic-Acid-Amplification-and-Expression-Profiling/Real-Time-PCR.html\"\u003eReal-Time PCR catalog\u003c/a\u003e.","elisa.pdp.productdetails.homogenousnowash":"Homogenous (no wash)","oligos.jpOligos.bulkUpload.field.scale":"Synthesis Scale *","antibody.serp.filter.laser.compatibility":"Laser Compatibility","antibody.searchresults.rowheader.expressionSystem":"Expression System","antibody.pdp.productDetail.hemagglutinationassay":"Hemagglutination Assay","antibody.pdp.productDetail.immunohistochemistryparaffin":"Immunohistochemistry (Paraffin) ","antibody.searchresults.rowheader.compare":"Compare","serp.filtertext.displayname.expressionsystem":"Expression System","global.search.results.mediaFormulationCard.resultType":"Media Formulation","elisa.crossSellCard.shopFor.antibody":"Shop for Antibodies","global.search.results.genomicsHelperCard.find":"Find {0} that match your search term \"\u003ca href\u003d\"{1}\"\u003e\u003cstrong\u003e{2}\u003c/strong\u003e\u003c/a\u003e\"","antibody.serp.filter.application":"Application","antibody.serp.compare.published.application":"Published Application","support.search.navigator.documentType.label.citations":"Citations \u0026amp; References","oligos.jpOligos.common.buttons.cancel":"Cancel","antibody.zero.results.reason.one":"Spelling or typing errors. You can use the product search to modify your search.","antibody.pdp.imageGallery.figure":"FIGURE","antibody.pdp.commerceCard.pendingTooltipMessage":"We can\u0027t get availability information for you right now. Items usually ship within 1 business day of when they become available.","antibody.pdp.productDetail.proteineassaysandanalysis":"Proteine Assays and Analysis","elisa.pdp.hero.techsupport":"Tech Support","antibody.pdp.reference.dilution":"Dilution ","global.search.results.cmgtProdCard.description":"Description","oligos.jpOligos.addOligo.minMaxOligoSequence":"Please enter a minimum of 7 and maximum of 30. Please make sure that there are no spaces before, after, or inside the sequence. U/I/F/E/O/Z are not allowed.","antibody.pdp.productDetail.lateralflow":"Lateral Flow","global.search.pagination.previousPage":"\u0026lt; Prev","antibody.pdp.productDetail.target":"Target","elisa.pdp.productdetails.detectorantibodyconjugate":"Detector antibody conjugate","antibody.zero.results.browse.all":"Browse all ","antibody.searchresults.rowheader.results":" results","antibody.pdp.commerceCard.requestBulkOrCustomFormat":"Request bulk or custom format","antibody.pdp.productDetail.tag":"Tag","antibody.zero.results.other.one":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}\"\u003e{2} other result\u003c/a\u003e on the site.","antibody.pdp.imageGallery.benchsci.disclaimer2":"Disclaimer","antibody.pdp.imageGallery.benchsci.disclaimer1":"By clicking this image or link above, you will be redirected to the Benchsci website. ","support.search.techSupport.navigation.contactProductSupport":"Contact Product Support","elisa.pdp.productdetails.unitproid":"UniProt ID","antibody.pdp.productDetail.orthoganalmethod":"Orthoganal method","antibody.pdp.commerceCard.catalog":"Catalog # ","global.search.noResults.youSearchedFor":"\u003cstrong\u003eSearch for:\u003c/strong\u003e \u003ch1\u003e${query}\u003c/h1\u003e \u003cem\u003e(0 matches)\u003c/em\u003e","antibody.serp.filter.clear.filters":"Clear","antibody.serp.compare.host.isotype":"Host/Isotype","antibody.pdp.productDetail.viewmore":"View more","support.search.techSupport.navigation.training":"Training","serp.filtertext.displayname.productgrade":"Product Grade","global.search.results.cmgtProdCard.resultType":"Catalog Product","common.search.modal.search.label.body":"*Please provide feedback to help improve our search:","support.search.placeholder.tip.structures":"by catalog number or product name","global.search.results.found":"You searched for: ","antibody.pdp.productDetail.independentantibody":"Independent antibody","antibody.pdp.imageGallery.benchsci.disclaimerMessage":"Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.","global.search.results.faqCard.askNewQuestion":"Ask a New Question","antibody.pdp.productDetail.hostIsotype":"Host/Isotype","antibody.pdp.imageGallery.advancedVerification":"Advanced Verification","global.search.results.geneCard.aliases":"Aliases","antibody.serp.compare.tested.applications.dilution":"Tested Applications / Dilution","antibody.serp.compare.contains":"Contains","immunoassay.elisa.zero.results.reason.two":"The protein target is listed under an alternate gene/protein name. Try searching for synonyms.","secondary.sitemap.description":"Secondary antibodies for fluorescent, colorimetric, and chemiluminescent detection. Wide selection of antibodies for Western blot, IHC, ICC/IF, Flow Cytometry \u0026 ELISA. Select a target species to view all formats.","global.search.results.cmgtProdCard.catNo":"Catalog #","oligos.jpOligos.addOligo.oligoNameMessage":"You may enter up to 30 single-byte alphanumeric characters, including (,), -, _, and spaces.","global.search.button.supportDocuments":"Support Documents","global.search.filter.productAttributeFilters":"PRODUCT FILTERS","antibody.searchresults.rowheader.remove":"Remove","antibody.pdp.relatedAntibodiesHeader":"Related Antibodies","oligos.jpOligos.bulkUpload.uploadOptionsDescription":"Selected options will be applied to all \u003cu\u003eblank\u003c/u\u003e entries of the spreadsheet and will not overwrite any existing spreadsheet selections.","serp.filtertext.displayname.antibodyform":"Antibody Form","global.search.secondaryResults.navigators.faq.nav1":"Applications","global.search.secondaryResults.navigators.faq.nav3":"Brands","antibody.searchresults.tabheader.antigens":"Epitopes","antibody.searchresults.row.figure":"figure","global.search.secondaryResults.navigators.faq.nav2":"Product Categories","antibody.pdp.hero.textProtocols":"Protocols","antibody.pdp.productDetail.viewless":"View less","antibody.serp.filter.protein.length":"Protein Length","info.tout.footer.exportTxt":"Export","antigen.searchresults.nosearchresultsmsg":"There are no antigen sequence ranges that match your search. Try resizing the end points in your range.","elisa.pdp.showMore.button":"Show More","elisa.crossSellCard.requestQuote":"Request a quote","serp.filtertext.displayname.researcharea":"Research Area","antibody.pdp.productDetail.viewadditionalformats":"View additional formats","antibody.serp.filter.host":"Host","antibody.pdp.commerceCard.checkYourPriceAndAvailability":"Check your price \u0026 availability","antibody.pdp.reference.journal":"Journal ","global.search.results.cmgtProdCard.contactUs":"Contact Us","info.modal.header.collaboratesharedListDesc":"You can invite collaborators like your lab \n manager or procurement staff to any shared \n list. They can add more items, leave \n comments and complete the final purchase. ","antibody.zero.results":"Zero Results.","antibody.pdp.panelBuilder.videoHeading":"How to use the Panel Builder","serp.filtertext.displayname.recombinant":"Recombinant","antibody.pdp.documents.msds":"Material safety data sheets (MSDS)","unified.card.gene":"Branched DNA gene expression assays","elisa.pdp.productdetails.proteinaliases":"Protein aliases","antibody.pdp.productDetail.knockdown":"KnockDown","antibody.pdp.imageGallery.testingData":"Testing Data","serp.filtertext.displayname.adv.verification":"Adv. Verification","crispr.zero.results.reason.four":"The product has been discontinued.","oligos.jpOligos.addOligo.complementOligo":"Complement Oligo","secondary.sitemap.titleprefix":"Secondary Antibodies","antibody.pdp.footer.performanceGuaranteeButton":"Learn more","info.modal.header.exportsharedListDesc":"Export your list as a spreadsheet for \n easy documentation or hand off to your lab’s \n designated buyer. ","antibody.pdp.imageGallery.relativeexpression":"Relative expression","antibody.searchresults.rowheader.application":"Application","serp.filtertext.displayname.clonality":"Clonality","antibody.pdp.commerceCard.productnotavailableinyourregion":"Product not available in your region","common.search.modal.search.button.cancel":"cancel","info.tout.footer.collaborateTxt":"Collaborate","unified.card.sirna":"siRNA","common.search.modal.faq.label.email":"Email Address:","global.search.results.brochureCard.download":"Download","antibody.serp.compare.tested.species.reactivity":"Tested Species Reactivity","global.search.results.citationCard.resultType":"Citations \u0026amp; References","antibody.pdp.productDetail.insituhybridization":"In Situ Hybridization","oligos.jpOligos.bulkUpload.templateDownloadHeader":"Click below to download the Excel template to your local computer","global.search.results.assayCard.resultType":"Assay","antibody.pdp.hero.techSupport":"Tech Support","antibody.serp.filter.target.class":"Target Class","support.search.techSupport.navigation.events":"Events","unified.card.crispr":"CRISPR guide RNA","flow.cytometry.search.text":"Target, gene symbol","support.search.noResults.noResultsFoundForQuery":"We did not find results for: \u003cstrong\u003e${query}\u003c/strong\u003e in \u003cstrong\u003e${supportSearchArea}\u003c/strong\u003e.","antibody.serp.filter.clone":"Clone","antibody.searchresults.row.price.not.available":"Price not available","antibody.serp.singleSearchTextKeywordSingular":"{0} result","common.search.modal.faq.validation.required.email":"Please provide an email address","global.search.button.addToCart":"Add To Cart","global.search.results.cmgtProdCard.miniPdp.heading":"Product Detail","elisa.serp.notFinding.section":"Not finding what you\u0027re looking for?","elisa.pdp.productdetails.intraassaycv":"Intraassay CV","antibody.pdp.productDetail.rnaimmunoprecipitation":"RNA Immunoprecipitation","antibody.serp.compare.description":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","oligos.jpOligos.bulkUpload.pasteSequenceDescription2":"","oligos.jpOligos.bulkUpload.pasteSequenceDescription1":"Please enter sequence individually, one record per line, separated by commas, with no space after the comma.","antibody.pdp.productDetail.miscellaneous":"Miscellaneous","antibody.serp.compare.storage.buffer":"Storage Buffer","elisa.pdp.hero.technicalguideprotocol":"Technical guide \u0026 protocol","antibody.pdp.productDetail.productSpecificationHeader":"Product Specific Information","antibody.pdp.productDetail.productspecifications":"Product Specifications","elisa.pdp.bioinformatics.proteinAliases":"Protein Aliases","serp.filtertext.displayname.application":"Application","global.search.listName.invalid":"Please enter a different list name that does not include the following: ?,/,\\,%,^,!","support.search.techSupport.navigation.instrumentRepair":"Instrument Repair","elisa.pdp.productdetails.proteinsubtype":"Protein subtype","oligos.jpOligos.common.buttons.addToCart":"Add To Cart","oligos.jpOligos.addProject.project":"Project","immunoassay.elisa.zero.results":"Zero Results.","common.search.results.catalogNumbers.label":"Catalog #s","serp.filtertext.displayname.uniprotid":"Uniprot ID","support.search.navigator.documentType.label.manualsAndProtocols":"Manuals \u0026amp; Protocols","serp.filtertext.displayname.proteinlength":"Protein Length","global.search.results.orderingWebFaq.heading":"Ordering \u0026amp; Web FAQ","antibody.pdp.hero.viewDetails":"View Details","serp.filter.moreText":"More","antibody.comparepage.disclaimer":"For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.","support.search.techSupport.navigation.manualsAndProtocols":"Manuals \u0026amp; Protocols","antibody.pdp.productDetail.control":"Control","antibody.serp.compare.expression.system":"Expression System","antibody.pdp.productDetail.concentration":"Concentration","microbe.zero.results.reason.four":"The Assay ID you entered does not match the species you selected. Note that you do not need to select a species to search by Assay ID.","serp.filtertext.displayname.proteinname":"Protein Name","antibody.pdp.productDetail.speciesReactivity":"Species Reactivity","antibody.pdp.suggestedSecondaryAntibodyHeader":"Suggested Secondary Antibodies","antibody.searchresults.tabheader.images":"Images","antibody.pdp.productDetail.molecularweight":"Molecular weight","control.sitemap.titleprefix":"Isotype Controls","oligos.jpOligos.addOligo.optional":"(optional)","antibody.searchresults.row.mostfigures.references":"Most Figures and References","global.search.results.coaCard.catNo":"Catalog #","antibody.pdp.commerceCard.pricenotavailable":"Price not available","antibody.searchresults.rowheader.figures":"Figures","oligos.jpOligos.common.buttons.bulkUpload":"Bulk Upload","elisa.pdp.productdetails.sampletypevolume":"Sample type/volume","antibody.pdp.productDetail.class":"Class","support.search.placeholder.tip.orderingWebFaq":"by keyword","antibody.pdp.productDetail.westernblotagglutination":"Western Blot (Agglutination)","antibody.comparepage.share":"Share","antibody.pdp.imageGallery.published.figure.supplied.by":"Published figure supplied by","antibody.serp.singleSearchTextKeywordPlural":"{0} results","antibody.pdp.imageGallery.antibodyTestingData":"Antibody Testing Data","support.search.placeholder.tip.coa":"by lot number or catalog number","antibody.pdp.commerceCard.availability.pending":"Pending","antibody.serp.filter.less.filters":"Less","antibody.pdp.productDetail.monoclonal":"Monoclonal","global.search.noResults.needHelp.heading":"Need Help?","antibody.serp.spellcheck.singleSearchTextKeywordPlural":"\u003cspan class\u003d\"regWeight\"\u003eNo results for\u003c/span\u003e \u003cstrong\u003e{1}\u003c/strong\u003e. \u003cspan class\u003d\"regWeight\"\u003eShowing \u003cstrong\u003e{0} results\u003c/strong\u003e for\u003c/span\u003e {2}","elisa.pdp.hero.target.information":"Target information","antibody.searchresults.row.figures":"figures","antibody.pdp.panelBuilder.videoDescription":"Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.","bid.common.tooltip.new.price.info":"\u003cstrong\u003ePrice:\u003c/strong\u003e Manufacturer suggested price \u003cbr\u003e \u003cstrong\u003eOnline price:\u003c/strong\u003e Web channel price","support.search.placeholder.tip.default":"by catalog number or product name","antibody.searchresults.rowheader.details":"Details","global.search.noResults.needHelp.technicalResources":"Technical Resources","antibody.pdp.productDetail.shippingcondition":"Shipping conditions","global.search.filter.persona.hitCount":"[{0}]","elisa.pdp.productdetails.speciestested":"Species (tested)","crispr.zero.results.reason.three":"The Assay ID you entered does not match the species you selected. Note that you do not need to select a species to search by Assay ID.","common.search.modal.search.heading.success":"Thank you for your feedback","global.search.filter.appliedFilters":"CURRENT FILTERS","antibody.pdp.reference.benchsci.disclaimer1":"By clicking the link above, you will be redirected to the Benchsci website. ","zrp.similar.results":"Search similar results in {0}","antibody.pdp.reference.benchsci.disclaimer2":"Disclaimer","antibody.serp.local.contactus":"Contact Us","antibody.searchresults.row.mostreferences":"Most References","support.search.placeholder.tip.productLiterature":"by catalog number or product name","supply.center.tooltip.info":"Products will be shipped from the nearest supply center.","antibody.searchresults.row.references":" References","serp.filtertext.displayname.clone":"Clone","antibody.searchresults.row.publishedfigures":" Published Figures","global.search.results.vectorCard.restrictions":"Restriction","global.search.results.msdsCard.catNo":"Catalog #","crispr.searchresults.rowheader.product":"Product","antibody.searchresults.rowheader.result":" result","global.search.noResults.querySuggestionWithNoResults":"Search for: \"\u003cstrike\u003e{0}\u003c/strike\u003e\" ({1} matches)","serp.filtertext.displayname.antigenspecies":"Antigen Species","antibody.pdp.reference.title":"Title ","global.search.results.geneCard.products":"Gene Based Products","oligos.jpOligos.bulkUpload.fileUploadDescription":"To upload multiple custom DNA oligo sequences, download the Sequence Template, enter the sequence information, and save as an .xls, .csv, or .txt file.","serp.nav.tabs.primary.antibodies":"Primary Antibodies","antibody.searchresults.row.without.keyword":"{0} {3}","antibody.serp.local.tfs":"This product is only available through your local Thermo Scientific supplier","oligos.jpOligos.bulkUpload.example":"Example","support.search.placeholder.tip.lull":"by catalog number or product name ","support.search.navigator.documentType.label.msds":"Material Safety Data Sheets","antibody.zero.results.reason":"Possible reasons that no {0} were found:","antibody.searchresults.row.not.orderable.online":"Not Orderable Online","antibody.serp.compare.add.to.cart":"Add to Cart","global.search.results.genomicsHelperCard.resultType.sirna":"siRNA","oligos.jpOligos.addProject.researcherNameMessage":"Only single-byte alphanumeric characters can be entered.","antibody.searchresults.row.with.keyword.results.header":"\u003cstrong\u003e{0} {3}\u003c/strong\u003e","antibody.searchresults.rowheader.target":"Target","antibody.pdp.productDetail.immunoelectrophoresis":"Immunoelectrophoresis","global.search.results.spectraCard.resultType":"Spectra Data","antibody.tfp.subheader.proteininformation":"Protein Information","global.search.results.brochureCard.documentType":"Product Literature","antibody.pdp.reference.subheading1":"Have you cited this product in a publication? ","antibody.pdp.commerceCard.yourprice":"Your Price","antibody.pdp.reference.subheading2":"Let us know","antibody.pdp.reference.subheading3":"so we can reference it in this datasheet.","crispr.zero.results.reason.one":"Spelling or typing errors. Use the product search above to modify your search.","global.search.results.minipdp.error.message":"This product cannot be ordered online or may be discontinued. For product status please contact \u003ca href\u003d\"http://template.lt.day.fqdn/content/lifetech/global/en/home/technical-resources/contact-us.html\"\u003eOrder Support\u003c/a\u003e.","antibody.pdp.commerceCard.onlineoffer":"Online Offer","antibody.searchresults.row.online.price.tooltip":"Online price is your best price.","support.search.noResults.executeQueryInSiteSearch":"Try this search against our \u003ca href\u003d\"{0}\"\u003eentire website results\u003c/a\u003e.","elisa.pdp.productdetails.geneid":"Gene ID","oligos.jpOligos.addOligo.reverseOligoName":"Reverse Oligo Name *","global.search.results.genomicsHelperCard.resultType.assay":"Assay","oligos.jpOligos.bulkUpload.uploadSelectFileDetails":"(.xls, .csv, or .txt format only; .csv or .txt only if using a procurement system)","oligos.jpOligos.addOligo.reverseComplementOligo":"Reverse Complement Oligo","antibody.serp.filter.target.species":"Target Species","antibody.pdp.reference.sortby":"Sort by","antibody.pdp.productDetail.invitroassay":"In vitro Assay","supply.center.button.text":"Supply Center","immunoassay.elisa.zero.results.reason":"Possible reasons that no {0} kits were found","global.search.results.cmgtProdCard.readMore":"View full product details \u0026gt;","antibody.sitemap.primary.description":"Extensively-validated primary antibodies for Western blot, IHC, ICC/IF, Flow Cytometry, Immunopreciption, ChIP, Functional assays, and other applications. Select a target to view all monoclonal and polyclonal antibodies.","serp.filtertext.displayname.lasercompatibility":"Laser Compatibility","global.search.results.manualCard.version":"Version","pdp.reference.text":"{0} Reference{1}","antibody.pdp.productDetail.gelshift":"Gel Shift","serp.filtertext.displayname.cellline":"Cell Line","antibody.pdp.productDetail.miscellaneouspubmed":"Miscellaneous PubMed ","oligos.jpOligos.messages.invalidOligos":"Please verify oligo parameters below","global.search.results.faqCard.resultType":"Product FAQ","serp.filtertext.displayname.targetclass":"Target Class","antibody.pdp.imageGallery.publishedFigures":"Published Figures","antibody.pdp.commerceCard.instock":"In stock","global.search.results.matches":"[{0} matches]","elisa.pdp.hero.about.this.kit.principleofmethod":"Principle of the method","support.search.placeholder.tip.manualsAndProtocols":"by catalog number or product name","antibody.pdp.hero.advancedVerification":"Advanced Verification","antibody.searchresults.rowheader.productGrade":"Product Grade","antibody.pdp.productDetail.gstpulldown":"GST Pull Down","global.search.results.vectorCard.polylinker":"Polylinker","antibody.pdp.productDetail.functionalassay":"Functional Assay","antibody.pdp.productDetail.immunohistochemistryfreefloating":"Immunohistochemistry - Free Floating","antibody.searchresults.rowheader.your.price":"Your Price ","global.search.listName.required":"Please enter a list name.","global.search.results.cmgtProdCard.quickProductInfo":"Quick Product Info","common.search.modal.search.label.email":"Email Address (Optional):","global.search.results.citationCard.authors":"Authors","support.search.techSupport.navigation.softwareDownloads":"Software Downloads","microbe.zero.results.header":"Your search for {0} returned {1} TaqMan® Microbe \u0026 ABR Detection Assays","elisa.pdp.productdetails.interassaycv":"Interassay CV","antibody.pdp.reference.more":"more","global.search.results.didyoumean":"Your search for \u003cb\u003e{0}\u003c/b\u003e returned no results. Showing results for \u003cb\u003e{1}\u003c/b\u003e.","antibody.pdp.productDetail.immunohistochemistry":"Immunohistochemistry ","elisa.pdp.productdetails.targetsubspecificity":"Target sub-specificity","global.search.results.assayCard.find":"Find {0} that match your search term \"{1}\"","global.search.noResults.resources.support":"View all Product Support Documents","oligos.jpOligos.bulkUpload.uploadSelectFile":"Please select your upload file","immunoassay.elisa.zero.results.browse.all":"Browse all ","elisa.pdp.productdesc.let.us.know":"Let us know so we can reference it here.","antibody.pdp.productDetail.seepublishedapplication":"View {0} publication{1}","antibody.pdp.productDetail.immunocytochemistry":"Immunocytochemistry","antibody.pdp.footer.performanceGuaranteeTitle":"Performance Guarantee","oligos.jpOligos.deleteOligo.message":"Are you sure you want to do this?","antibody.serp.compare.rrid":"RRID","crispr.searchresults.rowheader.compare":"Compare","tout.whatIsSharedList.titleTxt":"What is a shared list?","antibody.searchresults.rowheader.price":"Price ","antibody.serp.compare.species":"Species","antibody.searchresults.row.publishedfigure":" Published Figure","antibody.pdp.productDetail.recommendedHostIsotype":"Recommended Isotype Control","info.tout.header.sharedList":"Introducing shared lists","global.search.secondaryResults.navigators.orderingWebFaq.nav1":"Categories","antibody.pdp.productDetail.mobilepublishedapplication":"{0} publication{1}","oligos.jpOligos.bulkUpload.fileUploadDescriptionNote":"Note: Procurement system users must save as a .csv or .txt file.","antibody.pdp.productDetail.fluorescentquenching":"Fluorescent Quenching","serp.filtertext.displayname.tissuetype":"Tissue Type","oligos.jpOligos.basicEntry.subHeader1":"Order using the tool below or","oligos.jpOligos.basicEntry.subHeader2":"up to 200 oligo sequences at one time.","oligos.jpOligos.addOligo.primerName":"Oligo Name *","antibody.pdp.productDetail.proteinbiology":"Protein biology","antibody.searchresults.row.signin.user.tooltip":"Sign in","global.search.filter.topLevelFilters":"FILTER RESULTS BY","global.search.results.vectorCard.sequence":"Sequence","antibody.serp.filter.keepMyFilter":"Keep filters for Search","elisa.searchresults.rowheader.samplevolume":"Sample Volume","common.wsp.tooltip.supply.center.info":"Web orders only.","antibody.serp.compare.quantity":"Quantity","elisa.pdp.productdetails.targetsitespeificity":"Target site-specificity","global.search.results.cmgtProdCard.rfq":"request a quote","global.search.form.search.text.validation.message":"Please enter a search term","antibody.tfp.desc.viewless":"View less","serp.panel.builder.adText":"Building a flow cytometry panel?","common.search.modal.faq.button.submit":"submit","antibody.pdp.bioinformatics.functions":"Function(s)","antibody.pdp.bioinformatics.geneAliases":"Gene Aliases:","antibody.searchresults.sop.ends":"Ends","global.search.results.coaCard.resultType":"Certificate of Analysis","global.search.results.cmgtProdCard.unitSize":"Unit Size","global.search.noResults.noResultsFoundForQuery":"We did not find results for: \u003cstrong\u003e${query}\u003c/strong\u003e. ","global.search.results.coaCard.download":"Download","oligos.jpOligos.bulkUpload.field.purity":"Purification *","antibody.pdp.productDetail.peptideelisa":"peptide-ELISA","oligos.jpOligos.addOligo.reverseOligo":"Reverse Oligo","microbe.zero.results.contact.two":"QuantStudioFrontDesk@thermofisher.com","support.search.form.searcharea.dropdown.label":"in","antibody.pdp.hero.createCitation":"Create Citation","support.search.placeholder.tip.faq":"by catalog number, product name or keyword","support.search.form.query.input.label":"With these keywords","antibody.serp.compare.form":"Form","global.sharedList.noListTxt":"Create your first list","unified.card.mirna.dna":"Branched DNA miRNA assays","serp.filtertext.displayname.targetspecies":"Target Species","antibody.pdp.commerceCard.onlineprice":"Online Price","antibody.pdp.productDetail.publishedApplication":"Publications","antibody.pdp.productDetail.notapplicable":"Not applicable","antibody.searchresults.rowheader.species":"Species","unified.card.elisa":"ELISA kits","elisa.crossSellCard.assayDevelopment.specific.protein":"We provide assay development of your specific protein target.","antibody.serp.filter.clonality":"Clonality","antibody.serp.filter.conjugate":"Conjugate","global.search.results.vectorCard.catNo":"Cat. No.","antibody.pdp.commerceCard.longtermunavailablemsg":"This product is temporarily unavailable.","antibody.searchresults.row.from.invitrogen":"({2} {3} from Invitrogen)","global.search.form.search.button":"Search","antibody.pdp.imageGallery.view.product":"View Product","oligos.jpOligos.addOligo.purity":"Purification *","serp.filtertext.displayname.ptm":"PTM","antibody.searchresults.row.sop.special.offer":"Special offer","info.modal.header.createsharedListHeader":"Creating a shared list","antibody.tfp.subheader.synonyms":"Synonyms","antibody.searchresults.compare.add.product.to.compare":"+ Add a product to compare","antibody.pdp.productDetail.dilution":"Tested Dilution","antibody.serp.filter.cross.adsorbed":"Cross Adsorbed","microbe.zero.results.reason.one":"The product has been discontinued.","crispr.zero.results":"Zero Results.","elisa.pdp.hero.about.this.kit":"About This Kit","oligos.jpOligos.common.buttons.confirm":"Confirm","global.search.results.cmgtProdCard.ratings.notYetRatedLabel":"Rate this product","global.search.sortingOptions.dateSort.default":"Relevancy","common.search.modal.faq.validation.required.expectations":"Please select your expectation","antibody.searchresults.row.mobile.filters":"Filters","elisa.pdp.productdetails.shippingcondition":"Shipping conditions","antibody.pdp.reference.heading":"References","oligos.jpOligos.bulkUpload.header":"Custom DNA Oligos","global.search.results.lullCard.catNo":"Catalog #","elisa.pdp.hero.references":" References","common.search.modal.faq.label.expectations.met":"Met","elisa.pdp.productdetails.contents":"Contents","unified.card.pcr":"PCR and Sanger sequencing primers","antibody.serp.compare.published.species.reactivity":"Published Species Reactivity","antibody.pdp.relatedProductsHeader":"Related Products","antibody.pdp.productDetail.antibody":"Antibody","antibody.pdp.productDetail.knockout":"KnockOut","antibody.pdp.productDetail.viewspectra":"View spectra","antibody.pdp.footer.performanceGuaranteeText":"If an Invitrogen™ antibody doesn\u0027\u0027\u0027t perform as described on our website or datasheet,we\u0027\u0027\u0027ll replace the product at no cost to you, or provide you with a credit for a future purchase.*","antibody.searchresults.row.sop.online.purchase.only":"Online exclusive","antibody.pdp.commerceCard.discontinuedmsg":"This product has been discontinued","common.search.modal.search.label.contactMe":"May we contact you?","antibody.serp.filter.species":"Species","antibody.serp.compare.product.information":"Product Information","antibody.pdp.productDetail.excitationemissionprofile":"Excitation/Emission Max","global.search.results.minipdp.msds.heading":"MSDS","antibody.serp.filter.more.filters":"More","antibody.pdp.productDetail.immunoblot":"Immunoblot","serp.flt.srch.nomatchfound":"No match found","serp.panel.builder.adText.tryPBcn":" ","global.search.results.citationCard.journal":"Journal","control.sitemap.description":"Isotype control antibodies to help differentiate signal from background. Wide selection of negative controls for Flow Cytometry, IHC, Immunopreciptation, ChIP and other applications. Select a target class to view all formats.","antibody.pdp.productDetail.productDetails":"Product Details","elisa.pdp.productdetails.assayrange":"Assay range","info.modal.header.exportsharedListHeader":"Export as a spreadsheet","oligos.jpOligos.addOligo.complementOligoName":"Complement Oligo Name*","elisa.pdp.product.specifications":"Product Specifications","antibody.serp.compare.purification":"Purification","support.search.techSupport.navigation.heading":"Technical Resources","global.search.results.minipdp.vectors.heading":"Vector Maps","antibody.pdp.productDetail.celltreatment":"Cell Treatment","antibody.pdp.commerceCard.notorderableonline":"Not orderable online","oligos.jpOligos.bulkUpload.templateDownloadDescription":"Upload your saved sequence file here (.xls, .csv, or .txt format only; .csv or .txt only if using a procurement system).","elisa.pdp.productdetails.handsontime":"Hands-on time","elisa.pdp.productdetails.storage":"Storage","global.search.results.coaCard.lotNo":"Lot #","global.search.secondaryResults.navigators.citations.nav1":"Citation Journal","serp.nav.tabs.secondary.antibodies":"Secondary Antibodies","elisa.pdp.productdetails.proteinname":"Protein name","antibody.zero.results.reason.two":"The {0} is listed under an alternate gene/protein name. Try searching for synonyms.","global.search.sortingOptions.dateSort.label":"Sort By","elisa.searchresults.rowheader.assayrange":"Assay Range","info.modal.header.sharedList":"About shared lists","serp.filtertext.displayname.kitformat":"Kit Format","global.search.results.genomicsHelperCard.assayId":"Assay ID","oligos.jpOligos.addOligo.sequence":"Oligo Sequence (5\u0027 to 3\u0027) *","antibody.pdp.productDetail.type":"Type","antibody.zero.results.other.subtype":"Zero results for \"{0}\" but we found \u003ca href\u003d\"{1}query/{0}\"\u003e{2} {3}\u003c/a\u003e that match your search.","elisa.pdp.productdetails.instrument":"Instrument","serp.filtertext.displayname.brand":"Brand","antibody.serp.footer.custom.service":"Custom Antibody Service","elisa.pdp.hero.viewOther":"View all ({0}) {1} ELISA Kits","antibody.pdp.bioinformatics.molecularFunctions":"Molecular Function:","crispr.zero.results.reason.five":"The designated gene has no predesigned guide RNAs. Contact","common.search.modal.faq.heading":"Provide Feedback on this Answer"}; $m.magellanConfig = {"PlatesEnabled":"yes","newUserDataAPI":"https://tfcommerce-api-eks.cloud.thermofisher.net/api/store/v1/users/details","redisReplica":"magellan-redis-prod-us-east-1-ro.8k5m7q.ng.0001.use1.cache.amazonaws.com:6379","uglifyElisaSerp":"true","displayAssaySelectionVideo":"true","promoCodeEnabled":"true","sharedListUserName":"mguser","requeryOnZeroResults":"true","mediaGalleryServerSideRender":"true","oligoBaseURL":"/order/custom-oligo","saveItemToListURL":"/shared-list/addItemToList/","relatedProductsWidgetV2":"true","useMagellanPricingAPI":"true","ComergentBasePathAdirect":"/order/catalog/en/US/adirect/lt?cmd\u003d","pathwaysQueryPath":"/order/genome-database/pathwaysQuery?keyword\u003d","targetDetailsFromMetadataHandlerEnabled":"true","biozRestEndpoint":"https://back-gene-8.bioz.com/get_widget_data_multi/","regionalizedHostForCom":"www.thermofisher.com","useNewRedisCluster":"false","UserTrackingEnabled":"false","enableFishersciPriceUrl":"true","domain":"LT","citeAbUrl":"https://widget.citeab.com/citations?key\u003d15f4e791-1de2-4fad-b413-70c8829ee4c2\u0026code\u003d","promotionAvailabilityAPI":"/api/store/coupons/eligiblePromos","saveItemToListUrlNew":"/shared-list/addItemToList","removeUserBasedCookies":"false","enableBioz":"true","newSearchFormFiltersEnabled":"true","availabilityApiNotEnabledCountries":"US;CA","mapDataServer":"/api/magellan/alignmap/map-server","tfpDescriptionPreviewWordSize":"100","applicationsBySortOrderEnabled":"true","secAntibodyAdditionalFormat":"ON","useAlternateObjectCache":"ON","configurationSource":"YAML","uglifyCommonSerp":"true","magWebSvcsBase":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs","webCacheStatus":"ON","queryWithQuotes":"false","pearExpVerAllocations":"12","aspireAntibodyLink":"/us/en/home/products-and-services/aspire-member-program.html?cid\u003dbid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAAntibodyPDP2021","environmentConfig":"FrontEndAppServers,fastInstance,solrBaseUrl,genDBIdentifier,magWebSvcsBase,webMethodsBase,aimsSvcsBase,ComergentHost,assayValidationBase,assayDetailsServiceURL","ninetyNineImageCapEnabled":"true","maxSpellCheckOptionsToFetch":"5","clientId":"app-magellan-search","newFilterEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL","resultCountForProductSubTypesForMobileAndTFP":"antibody_primary:10","uglifyLegacyScripts":"true","MirnaSiteSearchLinkEnabled":"true","uglifyCompare":"true","geneOntologyPageSize":"40","addExtraCookieEnabled":"false","promotionalAdAPI":"/product/v1/promopod/","imagesS3Enabled":"true","newLogInpath":"/auth/login","newUserDetailsAPI":"/api/store/customer/users/v1/","enableElisaQuoteForKeywordSearch":"true","solrBaseUrl":"https://magellan-solr-prod-blue-solrcloud.magellanprod.thermofisher.net/solr","antibodyFamilyRedirects":"OFF","resultCount":"25","imageSearchEnabled":"true","microbeAssayUrl":"/microbe-detection/taqman/query/","awsFileNameForRedirectUrlRegEx":"Url_Redirect_RegEx.json","jsUnifier":"ON","galleryFilterEnabled":"true","mixedFamilyBrandSearch":"true","crisprSERPURL":"/crispr/invitrogen/query/","showUnreleased":"OFF","isProductionEnvironment":"true","scrollUpMinRowTablet":"1","useOptimizedResources":"ANTIBODY;IMMUNOASSAY;sirna;ge-quantigene;microrna;ceprimer;GE;GT;CNV;MIRNA;DPCR;CRISPRSRE","pdpHijackDisabledProducts":"CRISPR,MICROBE","CrossSellConjugateRule":"*Common_Applications \u003c Conjugate \u003c TradeName ^ Conjugate \u003c TradeName + Conjugate \u003c SKU","spellCheckEnabled":"true","magellanPathwaysBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/order/magellan-pathways","default-genePartURL":"/gene","ComergentUserInfoAPI":"/api/store/user-type/","antigenCacheControlTimestamp":"20220613","pathwaysImagemapPath":"/rest/PathwayDetailService/imagemap/","inventoryLocationCountryLists":"UK-AT-BE-BG-HR-CZ-DK-EE-FI-FR-DE-GB-GR-HU-IS-IE-IL-IT-LT-LU-MT-NL-NO-PL-PT-RO-SK-ES-SE-CH-TR","brightCovePanelBuilderVideoId":"6206990159001","ApplicationHost":"www.thermofisher.com","pantherPageSize":"40","techSupportEnabledCountries":"us;ca","availableReplicatesMCRB":"1,2,3,4,5,6","ComergentBasePath":"/order/catalog/en/US/direct/lt?cmd\u003d","aimsSvcsBase":"http://f1opd.corp.life:8080/aims-rest-service","spellCheckDisplayCount":"3","newPricingApi":"/api/magellan/pricing/","microbeEnabled":"true","awsRegion":"us-east-1","pricingAPICallGroupDelay":"200","custom_id_api_host":"/order/custom-genomic-products","DBSNPUrl":"//www.ncbi.nlm.nih.gov/projects/SNP","createOrRetrieveCartService":"https://tfcommerce-api-eks.cloud.thermofisher.net/api/store/carts/tp/retrieveCart?cartName\u003d","crsprTrueguideEnabled":"YES","unifiedAntibodySearchEnabled":"false","enableNewHeaderFooterForFisherSciForEU":"true","fisherSciStaticHost":"beta-static.fishersci.com","pricingWebWorkerEnabled":"true","useLegacyJsLibraries":"true","default-productPartURL":"/details","emailNotificationList":"marty.sherrill@lifetech.com","uglifyAntibodySerp":"true","aimsDescriptionServiceURL":"http://f1opd.corp.life:8080/aims-rest-service/descriptionForName","scrollUpMinRowMobile":"1","ComergentBasePathEntMgr":"/order/catalog/en/US/enterpriseMgr/lt?cmd\u003d","ApplicationHost-FISHERSCI_US":"www.fishersci.com","SolrEnabledProducts":"IMMUNO_ASSAY, ANTIBODY_TF, CRISPR_TF, MICROBE_TF, GENOTYPING","newAvailabilityApiEnabledCountries":"CN;KR;UK;AT;BE;BG;CM;HR;CZ;DK;EG;EE;FI;FR;GE;DE;GB;GR;HU;IS;IE;IL;JO;KZ;KE;LV;IT;LT;LU;MT;NL;NO;PL;PT;QA;RE;RO;RU;RS;SK;SI;ZA;ES;SE;CH;TN;TR;UA;AE","newPricingApiEnabledProducts":"ANTIBODY;IMMUNOASSAY","MyAvailabilityAPI":"/order/catalog/en/US/partnerMkt/lt?cmd\u003dvalidateAuthentication\u0026targetMessageType\u003dcommercePodOperations\u0026operation\u003dAvailability","HotJarID":"4539","coreRedisCacheTTLs":"productPDPHijackURL:604800,RelatedArraysCountCache:86400,KeywordGeneDataCache:86400,packageDataCache:90000,myPriceDataCache:43200,familyPageDetailsCache:86400,elisaFamilyPageDetailsCache:86400,antigenCountOnTFP:604800,catalogItemCache:86400,redirectProducts:-1,globalSearchResultsCache:86400","keepMyFiltersEnabled":"true","elisaSolrReQueryDisabled":"false","DomainName":"thermofisher.com","awsFolderNameForRedirectUrl":"productlist/","enableAdobeLaunch":"true","genePageSize":"100","secondaryConjugateOrder":"Functional Grade,Unconjugated,Biotin,AP,FITC,DyLight,Alexa Fluor,HRP,All Conjugates","pricingCacheMaxAge":"43200","techSupportModalEnabled":"true","isNewUserDataAPIEnabled":"false","dayServerBaseURL":"www.thermofisher.com","FASTSearchViewCache":"ON","brightcoveAccountId":"3663210762001","newAvailabilityAPI":"/api/store/sku/availability/","targetPageVideoEnabled":"true","chatEnabled":"false","catalogSearchEnabled":"true","ApplicationHost-fishersci":"www.fishersci.com","Authorization":"Bearer eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.eyJpc3MiOiJ3d3cudGhlcm1vZmlzaGVyLmNvbSIsImlhdCI6OTQ2Njg0ODAwLCJleHAiOjQwNzA5MDg4MDAsImF1ZCI6Ind3dy50aGVybW9maXNoZXIuY29tIiwic3ViIjoibWFnZWxsYW4ifQ.cHEqJM4Z9C8r_p4q8bJBAcj2SKdjqITlGkhHor9_Eig","headerFooterStyle":"DYNAMIC","awsBucketNameForRedirectUrl":"magellan-url-redirects-prod","microbeGlobalDyeSizeEnable":"false","jpPearUXVerAllocations":"2","relatedProductsEnabledProductSubTypes":"ANTIBODY_PRIMARY, ANTIBODY_SECONDARY, ANTIBODY_CONTROL","newAvailabilityAPIWithOAuth2":"/api/store/product/availability/v1/","advVerificationTag":"true","catalogAPI":"/api/store/product/catalog/v1/","fastInstance":"uspgh-tfmfa2-p2.amer.thermo.com:15100,uspgh-tfmfa2-p3.amer.thermo.com:15100,uspgh-tfmfa2-p4.amer.thermo.com:15100","resultCountForProductSubTypes":"antibody_primary:25,antibody_secondary:25,antibody_control:50,antibody_protein:50,elisa:50","allowShowMoreShowLess":"false","ComergentHost":"www.thermofisher.com","crsprEnabled":"YES","hideStackTracesInLogs":"false","catalogClientSecretKey":"magellan/prod/catalog-client-secret","tfpDescriptionPreviewConfig":"sm:66,700;md:110,500;lg:132,900","magellanPricingAPIPath":"/api/magellan/pricing/","customSearchAPI":"/api/magellan/product/customSearch","fishersci-priceUrl":"https://www.fishersci.com/shop/service/price","maxSKUsInPricingCall":"20","pearUXVerAllocations":"2","metadataHandlerEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ELISA,ANTIBODY_PROTEIN","imageSearchEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY","addToCartService":"http://tfcom-api.cloud.thermofisher.net/api/store/third-party-addtocart/add","elcanoNewToolEnabledProducts":"ge:ST,ge:PT,genotyping:ST,cnv:ST","useGlobalStyles":"ON","AntibodiesEuropeanCountryList":"UK-AT-BE-BG-CM-HR-CZ-DK-EG-EE-FI-FR-GE-DE-GB-GR-HU-IS-IE-IL-JO-KZ-KE-LV-IT-LT-LU-MT-NL-NO-PL-PT-QA-RE-RO-RU-RS-SK-SI-ZA-ES-SE-CH-TN-TR-UA-AE","bulkQuoteCustomFormPricingApiPath":"/fields/specifications,antibodyCustomForms","techSupportExtUrlForConjugatedPAB":"true","briefXmlFlag":"false","genomicProductSearchQueryPath":"/order/genome-database/genomicProductsQuery?keyword\u003d","siteSearchQueryPath":"/search/service/results?query\u003d","elisaPageSize":"80","pricingApiTimeout":"10000","primaryConjugateOrder":"Agarose,Functional Grade,Unconjugated,All Conjugates","newCatalogAPI":"https://tfpc-catalog.qa1.cloudqa.thermofisher.net/api/store/sku?catalogNumbers\u003d","multiplexEnabled":"NO","citeAbEnabled":"true","referenceCount":"true","crossContextHeaderFooter":"OFF","flexiblePanelAssayTypes":"sirius,tlda,tap1,tap2,beamr,tesli,teslc","newTFPProteinUrlEnabled":"true","promoAdEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL,ANTIBODY_PROTEIN,ELISA","pricingCallTimeoutSeconds":"10","enableBadges":"false","ComergentCookiePath":"/order","siteSearchProductApiTimeout":"5000","scrollUpMinRow":"1","debugProductSiteRegion":"false","epitopesModalImageMultiSizeEnabled":"true","antigenSearchEnabledSubTypes":"ANTIBODY_PRIMARY","regionalizedHostForCn":"www.thermofisher.cn","uglifyCoreScript":"true","useResponsiveOptIn":"false","enableProductSiteLogger":"false","newAvailabilityAPIWithOAuth2Enabled":"true","pearCookiesReductionEnabled":"true","browserCacheControl":"OFF","newGshEnabled":"true","filtersUrlEnabledProducts":"antibody;crispr;immunoassay;microbe","pearUXCookieName":"pearUXVerMar","panelBuilderMagWebApi":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/PanelBuilder.jsp","EHCache_memory_setting":"ehcache-aws-prod","orderedApplications":"WB,IHC,IHC (P),IHC (PFA),IHC (F),IHC (Free),ICC/IF,ICC,IF,Flow,ELISA,IP,ChIP,ChIP-seq,Neu,FN,LUM,RIA,Ctrl,PLA,ARRAY,DB,IM,IA,GS,pep-ELISA,IDF,RIP,BLOCK,IE,TCA,LF,AGG,ISH,CT,HA,AP,IV,FQ,CA,IRMA,WB-Ag,GPD,FRET,MISC","HeaderFooterMicroServiceHost":"tfpt-header-footer.tfcom-eks-na-comerce-gateway-prd.commerceprod.thermofisher.net","fishersci-newpriceUrlEU":"api.fishersci.eu/fishersci-pricing/priceandavail","referenceSortByFilterRemoved":"true","compareAnalyticsEnabled":"true","enableNjord":"false","JapanPVNOEnabledForOnlinePrice":"true","qandaEnabledProductSubTypes":"ANTIBODY_PRIMARY, ANTIBODY_SECONDARY, ANTIBODY_CONTROL","fullSizeImageEnabled":"true","oldFischerSciPricingUrl":"shop/service/price","pathwaysApplicationBase":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","enableShippingCondition":"true","filterSearchEnabled":"true","useMinifiedAssets":"false","adminEmail":"magellan.life@gmail.com","enablePdltMessage":"false","qnaWidgetAPI":"/api/magellan/qanda-ui/qna/widget/","hideTooltipForNewAvailabilityCountries":"CN","usePreloadedJS":"true","elcanoNewToolEnabled":"true","AssayDetailsServiceWarningThreshold":"3000","assayValidationBase":"http://f1opd.corp.life:8080/AssayValidation","ThirdPartySolrEnabledProducts":"ANTIBODY_TF","enableArrayConfiguratorCVIT":"true","thermoNonDotComEnabledCountries":"cn","magellanSearchFilter":"true","biozURL":"//nlpsearch-ptenlab-gene-8.appspot.com","tppEndCapEnabled":"false","techSupportModalEnabledSubTypes":"ANTIBODY_PRIMARY;ANTIBODY_SECONDARY;ANTIBODY_CONTROL","getAntigenCountInBackend":"true","newLogOutpath":"/auth/logout","hostName":"magellan-search-blue-5c9c5c4749-ffltp","enableProductTabsForMicrobe":"true","uglifyVendorScripts":"true","eksCluster":"magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","allowCommergentHostOverrides":"false","assaysEuropeanCountryList":"N/A","newTypeAheadEnabledProductSubTypes":"ANTIBODY_PRIMARY,ELISA","usePatternLibrary":"OFF","CmgtAddToCartService":"IVGNThirdPartyAddToCart","useRedis":"true","qnaLoaderThreshold":"#tf-related-products-container","errorLogDBInstance":"orcl_pri_gart","updateRegionalizedCanonicalUrlHost":"true","brightcoveApiSecretName":"magellan/prod/bcovpolicykey","SpeciesSortRelevancy":"ON","baseCatalogApi":"tfcommerce-api-eks-prod.commerceprod.thermofisher.net","ge-productPartURL":"/taqman-gene-expression/product","antigenSearchEnabled":"true","relatedProductsModuleURL":"/api/magellan/related-products-ui/widget/","techSupportExtUrl":"/home/technical-resources/contact-us/ext-antibody-technical-support","enablePrimaryEpitopeSrch":"true","assayIdsCount":"10","newTypeAheadEnabled":"true","redisCacheTTLs":"productPDPHijackURL:604800,RelatedArraysCountCache:86400,KeywordGeneDataCache:86400,packageDataCache:90000,myPriceDataCache:43200,familyPageDetailsCache:86400,elisaFamilyPageDetailsCache:86400,antigenCountOnTFP:604800,catalogItemCache:86400,redirectProducts:-1,globalSearchResultsCache:86400","ABPortalBaseURL":"(obsolete)","fastInstanceKey":"com.fastsearch.esp.search.http.qrservers","referenceFilterEnabled":"true","embeddedSearchFormDelay":"50","build-date":"2024-11-22T02:34:09Z","googleKey":"lW0Xt-iQmhGMfRn12R1YjbD1","KongGateway":"https://api.thermofisher.com","enableEstimatedAvailability":"true","qnaEnabledCountries":"CA,US","ComergentFilePath":"/order/catalog/en/US/css/ivgn/","biozHome":"https://www.bioz.com/tf_widget/","coreBuyerEmailAddress":"rashwor2@jhmi.edu,customorders@jhmi.edu,Manuel.Paniagua@thermofisher.com,Jose.Gutierrez@thermofisher.com,dave.kim@thermofisher.com","configurationInstance":"aws-prod-blue","newSourceIDToggle":"true","k8s-app-name":"magellan-search","CrossSellDbInstance":"orcl_pri_gart","solrSkuHijackEnabled":"true","enableOTMM":"true","sharedListURL":"/shared-list/getLists/","FisherSciEuropeanCountryList":"AT-BE-DK-FR-FI-DE-IE-IT-NL-NO-PT-ES-SE-CH-UK","medalliaEmbedJsToggle":"false","primaryPTMOrder":"Phosphorylated,Methylated,Acetylated,None","sequenceSearchServiceURL":"http://wmprd.thermofisher.com:5555/invoke/Life_GenomicsDesigns.process/receiveXML","newAvailabilityApiEnabled":"true","qnaModuleEnabled":"true","allConjugateEnabledProductSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL","debugMode":"OFF","redirectToSiteSearchForMagellanZR":"false","sharedListsURL":"/us/en/home/technical-resources/ordering-web-faqs/shopping-cart-checkout/how-to-order/order.html#container-217a2","awsFileNameForRedirectUrl":"URL_Redirects.xlsx","productSearchCountAPI":"/api/magellan/product-service/getProductSearchCount?keyword\u003d","newGlobalSearchAPIEnabled":"true","HttpProtocol":"https://","elcanoNewToolBasePath":"/taqman","keywordTypeaheadBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net/solr/lt-magellan-search-core/select","1000GenomesUrl":"//www.ncbi.nlm.nih.gov/variation/tools/1000genomes","jpPearExpVerAllocations":"1","enableNewHeaderFooter":"true","useFisherSciMfgPart":"false","MicrobeConfiguratorPath":"/microbe-detection/taqman/target-list/array-configurator-open","sharedListEligibleURL":"/order/catalog/msg/lt/rest/adirect/countries/SharedListEligible/","pathwaysReferencesPath":"/rest/PathwayDetailService/references/","pathwaysDescriptionPath":"/rest/PathwayDetailService/description/","benchSciImageLimit":"40","hideGeneDetailsProdTypes":"taqman,ge,plate,genotyping,cnv,microrna,dpcr,mutation,sirna,antibody","maxNoOfPublishedImages":"40","enableSOLRSearch":"true","redisMaster":"magellan-redis-prod-us-east-1.8k5m7q.ng.0001.use1.cache.amazonaws.com:6379","pubmedUrl":"http://pubmed.ncbi.nlm.nih.gov/pubmed/","loggingLevel":"DEBUG","pearExpSetupCookies":"NA","alternateSEOUrl":"EN-US;ZH-CN;EN-CN;x-default","bannerMessagesEnabled":"true","antibodyCacheControlTimestamp":"20240507","uglifyCommonPrimaryScripts":"true","ComergentProductPath":"/order/catalog/product/","isTfKongEnabled":"true","catalogAPIGatewayWithOauth2Enabled":"true","kongCreateCartService":"/api/store/carts/tp/retrieveCart","maxKeywordLength":"250","packageSource":"LT","enableJPSpecificStyle":"false","ProtectedBatchSearchMode":"OFF","newDocumentsApiExpanded":"true","newPricingApiDisabledCountries":";","ConfigurationSource":"YAML/aws-prod-blue/pgres_pri_gart_new","technicalSupportContactURL":"/global/en/home/technical-resources/contact-us.html","hostIp":"100.66.78.226","cacheStatus":"ON","userProfileService":"http://tfcom-api.cloud.thermofisher.net/api/store/v1/users/basicDetails","redirectUrlEnabled":"false","relatedProductsEnabled":"true","x-application":"magellan","chinaSupplyCenterEnabled":"true","proteinPageSize":"80","assayValidationApi":"http://f1opd.corp.life:8080/AssayValidation/processXml","videoInImageGalleryToggle":"true","HeaderFooterHost":"www.thermofisher.com","renderHeaderFooterViaSSI":"true","cacheControlTimestamp":"20240917","kongCartAddService":"/api/store/ordering/cart/v1","enableSop":"true","newDocumentsApiEnabled":"true","TargetRedirectEnabled":"true","keepMyFiltersEnabledSubTypes":"ANTIBODY_PRIMARY,ANTIBODY_SECONDARY,ANTIBODY_CONTROL,ANTIBODY_PROTEIN,ELISA","aspireElisaLink":"/us/en/home/products-and-services/aspire-member-program.html?cid\u003dbid_asp_sbu_r02_co_cp1438_pjt7721_col015466_0wm_tfs_df_awa_at_s00_PCAELISAPDP2021","citationLinks":"5","enableBulkQuoteCustomForm":"true","awsMetadataURL":"http://169.254.169.254/latest/meta-data/local-ipv4","webMethodsBase":"http://wmprd.thermofisher.com:5555","ge-genePartURL":"/taqman-gene-expression/gene","fischerSciPricingUrl":"fishersci-pricing/priceandavail","enableNewHeaderFooterForFisherSci":"true","allConjugateCountThreshold":"5","assayStatusServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayStatus.jsp","magellanPricingAPILogs":"false","pdpProductSchemaEnabled":"true","regionalizedEnabledCountries":"CN","elisaTFPEnabled":"true","techSupportExtUrlForUnConjugatedPAB":"true","specialOfferPricingEnabledCountries":"US;CA;FI;ZA;DK;ES;NL;UK;OM;AT;CZ;HU;BG;FR;SI;SE;JO;LB;NO;CH;IE;PL;RO;BE;MK;MT;EG;GR;HR;SK;RS;AL;BA;BH;KW;KE;GB;DE;IT;IQ;QA;AE;SA;LY;ME;YE;CY;IL;PT;AD;AF;AI;AM;AO;AS;AW;AZ;BF;BI;BJ;BV;BW;BY;CC;CF;CG;CI;CM;CV;CX;DJ;DZ;EE;EH;ER;ET;FK;FO;FX;GA;GE;GF;GH;GL;GM;GN;GP;GQ;GS;GW;HM;IM;IO;IS;KG;KI;KM;KN;KZ;LC;LR;LS;LT;LU;LV;MA;MC;MD;MG;ML;MN;MQ;MR;MU;MW;MZ;NA;NC;NE;NF;NG;NR;NU;PF;PM;PN;PS;PW;RE;RU;RW;SB;SC;SH;SJ;SL;SM;SN;ST;SZ;TC;TD;TF;TG;TJ;TK;TM;TN;TR;TV;TZ;UA;UG;UZ;VA;VC;VG;VU;WF;YT;ZM;ZW","formatFilterEnabled":"true","useNewBrightCoveVideoPlayer":"true","genDBIdentifier":"orcl_pri_gen2","sharedListUserPwd":"mgprd@user","fisherSciSearchFormPageId":"IU5R4C73","chatBaseApiUrl":"https://chat-api.thermofisher.com","schemaMarkupEnabledForSERP":"true","newComparePanelEnable":"true","schemaMarkupEnabled":"true","spectraHost":"/order/fluorescence-spectraviewer","newChatGateWayEnabled":"false","searchXmlServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayAnnotSearch.jsp","pearUXSetupCookies":"NA","IVGNaddToCartServiceURL":"/order/catalog/en/US/adirect/lt?cmd\u003dIVGNThirdPartyAddToCart","outboundEmailServer":"smtp.cloud.thermofisher.net","siteSearchProcessTimeout":"100","filterSearchExactFacetEnabled":"false","magellanClusterBaseURL":"https://magellan.tfcom-eks-na-magellanprod.magellanprod.thermofisher.net","pathwaysDetailsPath":"/rest/PathwayDetailService/detail/","translationEnabledProducts":"antibody;immunoassay","solrReQueryDisabled":"true","techSupportModalEmailFormUrl":"/home/technical-resources/contact-us/antibody-technical-support","geneDetailDataEnabled":"true","panelBuilderResultCount":"300","customToolBaseURL_sansProtocol":"/order/custom-genomic-products","redisSecret":"magellan/redis","lucidWorksAPIHostURL":"tfsearch-store-nginx-prod.srchcloudprod.thermofisher.net","newProteinUrlEnabled":"true","FrontEndAppServers":"http://magellan-srch-1-prod-blue.cloud.thermofisher.net:8080~~~http://magellan-srch-2-prod-blue.cloud.thermofisher.net:8080~~~http://magellan-srch-3-prod-blue.cloud.thermofisher.net:8080","userDataAPI":"http://tfam-users.prod.cloud.thermofisher.net/api/store/users/details","inventoryDataServiceUrl":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayInvLoc.jsp","pdltApplicableCountryList":"KR;CN","ApplicationBasePath":"/order/genome-database","spellCheckKeywords":"{\u0027keywords\u0027: [{\u0027antibody\u0027: \u0027anibody;anitbody;antabody;antbodie;antbody;anti-body;antibode;antibodi;antobody\u0027}]}","CommerceServiceYourPricePerSKUWarningThreshold":"5000","skuSummary":"/search/api/summary/sku/en/US/","assayDetailsServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/AssayAnnot.jsp","microbeBatchTermsLimit":"1000","mixedBrandSearch":"true","showUnentitled":"OFF","enableNewPricingTooltip":"true","sortSpellCheckCollations":"true","moveJqueryToBody":"true","blockPooledAssaysFormat":"TACMIRNA,SIRIUS,TLDA,TAP2,TAP1","packageServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/Package.jsp","crisprV2Enabled":"true","CommerceServiceListPricePerSKUWarningThreshold":"2000","fishersci-newpriceUrlUS":"api.fishersci.com/fishersci-pricing/priceandavail","categoryPageServiceURL":"http://magellan-data.prod.magellanprod.thermofisher.net/MagWebSvcs/GenomicListData.jsp","elisaImageGalleryToggle":"true","FisherSciEuropeanDomain":"www.fishersci"}; $m.countryCode = ""; // to point the header urls to local.thermofisher.com for local environment if ("aws-prod-blue".toLowerCase() === "local") { window.environmentURL.WCMSERVER = $m.magellanConfig['ApplicationHost']; } </script> </body> </html>