CINXE.COM

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about="/products/cultrex-basement-membrane-extract-bme-and-extracellular-matrices-ecm" typeof="sioc:Item foaf:Document"> <header> <span property="dc:title" content="Cultrex™ Extracellular Matrices for 2-D and 3-D Cell Culture Applications" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </header> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><style type="text/css">.arrow-left {width: 0; height: 0; border-top: 10px solid transparent; border-bottom: 10px solid transparent; border-left: 10px solid white; position: relative;left: -15px;top: -9px;} .padded_row {padding: 15px 0;} .cultrex_table_wrapper { display: block; height: auto; width: 100%; overflow-x: scroll; } </style> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="quality col-xs-12 col-sm-8"> <p> </p> <p>Products include a full range of basement membrane extracts (BME) and purified extracellular matrix (ECM) proteins, including Laminin I, Collagen I, Collagen IV, and Vitronectin. Select Cultrex BME and ECM products undergo additional qualification for use in 3-D cultures, stem cell cultures, and cell invasion assays.</p> <p> </p> <p style="margin-top: 20px"><a class="btn btn-tertiary" href="#Cultrex BME">Cultrex BME</a> <a class="btn btn-tertiary" href="#cultrex-ecm">Cultrex ECM Proteins</a> </p> <p> </p> </div> <div class="discovery col-xs-0 col-sm-4"> <p><a href="https://www.youtube.com/watch?v=TZQ_W0ZvdOU&t=1s" target="_blank"><img alt="Human Instestinal Organoids Grown with Cultrex UltiMatrix Video" class="image-responsive" src="//resources.rndsystems.com/images/design/intestinal-organoid-293x172-v2.jpg" /></a></p> <p>MUC2 (magenta) Expression in Human Intestinal Organoids Grown Using Cultrex UltiMatrix RGF BME. Video obtained by LifeCanvas Technologies.</p> </div> </div> </div> </div> </div> <div class="row" style="background-color: #03263a; padding: 10px 0px 20px 40px; margin: 20px 0px 20px 0px"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="quality col-xs-12 col-sm-8"> <h2 style="color: #FFFFFF">Our Cultrex Matrices are In Stock and Ready to Ship!</h2> </div> <div class="discovery col-xs-0 col-sm-4"> <p><a class="btn btn-primary" href="https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/sample-request" style="color: #FFFFFF" target="_blank">Request a Matrix Sample</a></p> </div> </div> </div> </div> </div> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="quality col-xs-12 col-sm-8"> <h3>Cultrex: Your Extracellular Matrix Solution</h3> <p>Cultrex BMEs are a mixture of specialized protein extract purified from the Engelbreth-Holm-Swarm (EHS) murine tumor. These extracts provide a natural extracellular matrix hydrogel that polymerizes at 37 °C to form a reconstituted basement membrane that is used to promote and maintain a differentiated phenotype of cell cultures such as epithelial cells, endothelial cells, glandular cells, neurons, and smooth muscle cells. BME can also be utilized in cell attachment, neurite outgrowth, angiogenesis, <em>in vitro</em> cell invasion and <em>in vivo</em> tumorigenicity assays.</p> <p><strong>Product Features</strong></p> <ul> <li>Rapid - gels within 30 minutes at 37 °C.</li> <li>Reliable - maintains gelled form in culture medium for 14 days.</li> <li>Sterile - screened for bacteria, fungi, and mycoplasma.</li> <li>Specific - available with reduced growth factor content, with or without Phenol Red</li> </ul> </div> <div class="discovery col-xs-0 col-sm-4"> <p><a href="//resources.rndsystems.com/pdfs/posters/rndsystems-sp-ultimatrix-scientific-poster-final.pdf" target="_blank"><img alt="Cultrex UltiMatrix RGF Basement Membrane Extract Scientific Poster" class="image-responsive" src="//resources.rndsystems.com/images/design/rndsystems-ultimatrix-scientific-poster-thumb.jpg" /><br /> UltiMatrix Extracellular Matrix Scientific Poster</a></p> </div> </div> </div> </div> </div> <p>Our most advanced extracellular matrix, <strong><a href="/products/cultrex-ultimatrix-reduced-growth-factor-basement-membrane-extract_bme001-05">Cultrex UltiMatrix RGF BME</a></strong>, is specially formulated with higher extracellular protein content, consistency, and clarity for optimal organoid, spheroid, and pluripotent stem cell culture.</p> <div class="row"> <div class="padded_row"> <div class="container"> <div class="row"> <div class="partner col-xs-8" style="margin-top: 30px"> <h3><a id="Cultrex BME" name="Cultrex BME"></a>Cultrex Basement Membrane Extracts </h3> <p>Cultrex BME Matrices for 2-D and 3-D culture are offered in multiple formats to support application-specific needs. Cultrex Reduced Growth Factor (RGF) BME, which is processed to reduce matrix-associated growth factors, is ideal for research that requires a more defined model system. Cultrex UltiMatrix, as our most advanced matrix, is recommended for all below applications since its enhanced composition and consistency can benefit many types of cultures.</p> <p style="margin-top: 30px">For additional guidance on matrix selection and protocols for use, including handling tips, see the <strong><a href="https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/cell-culture-matrix-for-your-research">Cultrex ECM Selection and Use Guide</a></strong>.</p> </div> <div class="discovery col-xs-0 col-sm-4" style="margin-top: 30px"> <p><a href="https://www.youtube.com/watch?v=gr55xvU-GW8" target="_blank"><img alt="Cultrex ECM Testimonial Video" class="image-responsive" src="//resources.rndsystems.com/images/design/cultrex-bme-testimonials-293x172-v2.jpg" /></a></p> <center><strong>Cultrex BME Matrix Testimonial</strong></center> </div> </div> </div> </div> </div> <div> </div> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="partner col-xs-12"> <div class="cultrex_table_wrapper"> <table align="center" cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <thead> <tr class="info"> <th>Name</th> <th>Application</th> <th>Description</th> <th>RGF Version Available?</th> <th>Notes</th> </tr> </thead> <tbody> <tr> <td><a href="/products/cultrex-ultimatrix-reduced-growth-factor-basement-membrane-extract_bme001-05" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex UltiMatrix RGF BME</a></td> <td>Organoids and Stem Cells</td> <td>Soluble form of basement membrane that provides high tensile strength, enhanced levels of entactin/nidogen, elevated protein concentration, and robust clarity and purity.</td> <td><a href="/products/cultrex-ultimatrix-reduced-growth-factor-basement-membrane-extract_bme001-05" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Yes</a></td> <td>This matrix contains compositional enhancements and performance benefits for organoid and stem cell culture</td> </tr> <tr> <td><a href="/products/cultrex-stem-cell-qualified-reduced-growth-factor-basement-membrane-extract_3434-010-02" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex Stem Cell Qualified BME</a></td> <td>Stem Cells</td> <td>Provides an effective feeder-free surface for the attachment and maintenance of stem cells in an undifferentiated state, enabling growth promotion or study of stem cell differentiation.</td> <td><a href="/products/cultrex-stem-cell-qualified-reduced-growth-factor-basement-membrane-extract_3434-010-02">Yes</a></td> <td>Attachment and maintenance of stem human embryonic and induced pluripotent stem cells</td> </tr> <tr> <td><a href="/products/cultrex-readybme-stem-cell-qualified-reduced-growth-factor_3434-050-rtu" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex ReadyBME, Stem Cell Qualified</a></td> <td>Stem Cells</td> <td>Pre-diluted, pre-qualified ready-to-use basement membrane extract for feeder-free pluripotent stem cell maintenance and differentiation.</td> <td><a href="/products/cultrex-readybme-stem-cell-qualified-reduced-growth-factor_3434-050-rtu">Yes</a></td> <td>Improves experiment consistency and success by minimizing user handling and coating matrix dilution variability</td> </tr> <tr> <td><a href="/products/cultrex-3-d-culture-matrix-reduced-growth-factor-basement-membrane-extract-pathclear_3445-010-01" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex 3-D Culture Matrix BME</a>*</td> <td>3-D Tissue Spheroids</td> <td>BME used for modeling the morphological effects of early oncogenesis on 3-D microenvironments, wherein healthy, differentiating cells exhibit a structured, polarized morphology that is critical for tissue formation and function. Specifically produced for and qualified in 3-D culture studies.</td> <td><a href="/products/cultrex-3-d-culture-matrix-reduced-growth-factor-basement-membrane-extract-pathclear_3445-010-01">Yes</a></td> <td>3-D cell cultures</td> </tr> <tr> <td><a href="/products/cultrex-basement-membrane-extract-type-2-pathclear_3532-010-02" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex Organoid Qualified BME, Type 2</a>*</td> <td>Organoid</td> <td>A Reduced Growth Factor BME that has been developed and qualified specifically for robust organoid cultures.</td> <td><a href="/products/cultrex-reduced-growth-factor-basement-membrane-extract-type-2-pathclear_3533-010-02">Yes</a>*</td> <td>Robust organoid cultures</td> </tr> <tr> <td><a href="/products/cultrex-reduced-growth-factor-basement-membrane-extract-type-r1_3433-010-r1" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex Organoid Qualified BME, Type R1</a></td> <td>Organoid</td> <td>A Reduced Growth Factor BME that has been developed and qualified specifically for difficult organoid cultures.</td> <td><a href="/products/cultrex-reduced-growth-factor-basement-membrane-extract-type-r1_3433-010-r1">Yes</a></td> <td>Difficult to culture organoids</td> </tr> <tr> <td><a href="/search?keywords=BME%20Type%203&common_name=Basement%20Membrane%20Extracts" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex BME, Type 3</a>*</td> <td>Cancer/Tumorspheres</td> <td>BME Type 3 helps cells to adapt to <em>in vivo</em> transplantation. Mimicking the <em>in vivo</em> microenvironment, including low glucose and low pH, to improve take rate and growth of implanted cells for xenograft and tumorgraft models.</td> <td>No</td> <td>Xenograft/Tumorgrafts</td> </tr> <tr> <td><a href="/products/cultrex-basement-membrane-extract-pathclear_3432-010-01" style="color: rgb(112, 146, 177); text-decoration-line: underline;">Cultrex BME</a>*</td> <td>General</td> <td>Consists of laminin I, type IV collagen, entactin, and heparan sulfate proteoglycan.</td> <td><a href="/products/cultrex-reduced-growth-factor-basement-membrane-extract-pathclear_3433-010-01">Yes</a></td> <td>General use including 2-D cultures, 3-D cultures, cell attachment and cell invasion</td> </tr> </tbody> </table> </div> <p>*product available with or without Phenol Red</p> </div> </div> </div> </div> </div> <p><a id="cultrex-ecm" name="cultrex-ecm"> </a></p> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="partner col-xs-12"> <h3>Cultrex ECM Proteins Portfolio</h3> </div> <div class="quality col-xs-12 col-sm-8"> <p>Cultrex ECM Proteins provide a defined substrate for cell adhesion in culture. Many proteins of the ECM interact with cells via cell surface integrin family receptors. The resulting focal contacts are important for the maintenance of tissue architecture and for supporting a variety of cellular processes. ECM molecule/integrin binding may initiate a complex network of signal transduction cascades that, depending on the context, play an important role in cell spreading, migration, proliferation, and differentiation during embryogenesis, wound healing, and tumor development. To accommodate a variety of different models, we have developed a full range of ECM component proteins including Laminin I, Collagen I, Collagen IV, and Vitronectin. These include purified proteins that have been qualified for 3-D or stem cell cultures.</p> </div> <div class="discovery col-xs-0 col-sm-4"> <p><a href="https://www.youtube.com/watch?v=mhja5Rv9bqk" target="_blank"><img alt="Cultrex BME Best Practices Video" class="image-responsive" src="//resources.rndsystems.com/images/design/cultrex-bme-practices-293x172-v2.jpg" /></a></p> <center> <p style="padding-top: 10px"><strong>Cell Matrices Best Practices</strong></p> </center> </div> </div> </div> </div> </div> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> <div class="partner col-xs-12"> <table align="center" cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <thead> <tr class="info"> <th>Name</th> <th>Description</th> <th>Catalog #</th> </tr> </thead> <tbody> <tr> <td>Mouse Laminin I</td> <td>A purified basement membrane protein that has been developed, produced and qualified specifically for cell culture studies where the presence of pathogens may cause concern.</td> <td><a href="/search?keywords=3400-010">View All</a></td> </tr> <tr> <td>Mouse Collagen IV</td> <td>Used for coating of tissue culture surfaces to promote cell attachment and proliferation and to study its effects on cell behavior.</td> <td><a href="/products/cultrex-mouse-collagen-iv_3410-010-02">View All</a></td> </tr> <tr> <td>Rat Collagen I</td> <td>Major structural component of extracellular matrices found in connective tissue and internal organs, used to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. The 5 mg/ml concentration is very viscous for researchers wanting a thicker Collagen.</td> <td><a href="/search?keywords=Rat%20Collagen%20I&category=Cell%20Culture%20Products">View All</a></td> </tr> <tr> <td>Rat Collagen I, Lower Viscosity</td> <td>Diluted to a lower concentration (3 mg/ml); it is less viscous and easier to handle. A major structural component of extracellular matrices found in connective tissue and internal organs, but is most prevalent in dermis, tendons, and bone. It promotes cell attachment, proliferation, differentiation, migration, and tissue morphogenesis.</td> <td><a href="/products/cultrex-rat-collagen-i-lower-viscosity_3443-100-01">View All</a></td> </tr> <tr> <td>Vitronectin</td> <td>Vitronectin is a large glycoprotein found in blood and the ECM. Vitronectin contains multiple binding sites for a variety of structures.</td> <td><a href="/search?keywords=Vitronectin">View All</a></td> </tr> <tr> <td>3-D Culture Extract Laminin I</td> <td>3-D Culture Matrix<sup>™</sup> Mouse Laminin I may be used as a gel on which to grow cells, as a media additive alone or in concert with other basement membrane components, or to study cellular growth and differentiation in three dimensions <em>in vitro</em>.</td> <td><a href="/products/cultrex-3d-culture-matrix-laminin-i_3446-005-01">View All</a></td> </tr> <tr> <td>3-D Culture Extract Rat Collagen I</td> <td>The 3-D Culture Matrix<sup>™</sup> Collagen I may be used as a gel on which to grow cells or a media additive alone or in concert with other basement membrane components to study cellular growth and differentiation in three dimensions <em>in vitro</em>.</td> <td><a href="/products/cultrex-3d-culture-matrix-rat-collagen-i_3447-020-01">View All</a></td> </tr> </tbody> </table> </div> </div> </div> </div> </div> <p><a id="cultrex-bme-assays" name="cultrex-bme-assays"> </a></p> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"><span style="color: inherit; font-family: verdana, futura, sans-serif; font-size: 15px; font-weight: bold;">ExCellerate™ GMP iPSC Expansion Medium</span></div> <div class="padded_row">For seamless transition from our equivalent RUO iPSC Expansion Medium. Both media support robust expansion and maintenance of pluripotent stem cell culture for enhanced consistency and reproducibility.</div> <ul> <li>Completely animal-free</li> <li>All-in-one formulation</li> <li>Stable cell integrity over long term culture</li> </ul> <p style="margin: 20px 0px 30px 0px"><a class="btn-primary btn" href="https://www.bio-techne.com/promotions/excellerate-ipsc-medium-sample" target="_blank">Try Our GMP iPSC Expansion Medium</a></p> </div> </div> </div> </div></div></div> </article> </section> <section id="block-block-26" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height: 48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button 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