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class="crumb"><a href="https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.comgeneral/">General</a></span> <i class="fa fa-angle-right"></i> <span class="current">Dermal Burn Modeling</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <p> <img class=" wp-image-5427 alignleft" src="https://www.compbio.com/images/CBI-Burn-Modeling.image_.png?v=1712604970" alt="" width="982" height="458" srcset="https://www.compbio.com/images/CBI-Burn-Modeling.image_.png?v=1712604970 849w, https://www.compbio.com/images/CBI-Burn-Modeling.image_-300x140.png?v=1712604964 300w, https://www.compbio.com/images/CBI-Burn-Modeling.image_-768x358.png?v=1712604957 768w" sizes="(max-width: 982px) 100vw, 982px"> </p> <p>Thermal and UV burns represent an unmet medical need, particularly in defense or military settings.  CBI has a number of humane, validated and optimized superficial, partial thickness and full thickness burn models in rodents and pigs, including mini and Duroc pigs.  We have evaluated a number of therapeutic regimes including biologics and stem cell treatments as well as small molecules and immunomodulatory agents in Burns and Dermatitis.</p> <h2>Methods of assessment include:</h2> <ul> <li>Wound healing progression with digital image analysis of wound size and closure</li> <li>Draize scoring</li> <li>Transepidermal water loss</li> <li>Body temperature and body weights, food consumption</li> <li>Hematology and clinical chemistry</li> <li>Serum and tissue markers of inflammation</li> <li>Serial biopsies</li> <li>Histopathology and photomicroscopy</li> <li>Special stains and immunohistochemistry</li> <li>Histomorphometry</li> <li>Custom upon request</li> </ul> <p style="text-align: center;">Complete, timely reporting suitable for regulatory submission (GLP and non-GLP studies).</p> <p style="text-align: center;">For more detailed information visit our <strong><a href="https://www.compbio.com/files/White-Paper-Burn-model-Final.pdf?v=1712251949">white paper</a></strong></p> <p style="text-align: center;">For more detailed information review our <em>2021 TECHNICAL BULLETINS: </em><a href="https://www.compbio.com/newsletters-2-2/">Dermal Burn Modeling</a>.</p> <figure id="attachment_1046" aria-describedby="caption-attachment-1046" style="width: 300px" class="wp-caption alignleft"> <a href="https://www.compbio.com/images/102-500-g-2-min-full-400x.jpg?v=1712609297"><img loading="lazy" class="size-medium wp-image-1046 " src="https://www.compbio.com/images/102-500-g-2-min-full-400x-300x225.jpg?v=1712252236" alt="Thermal Burn Modeling" width="300" height="225" srcset="https://www.compbio.com/images/102-500-g-2-min-full-400x-300x225.jpg?v=1712252236 300w, https://www.compbio.com/images/102-500-g-2-min-full-400x.jpg?v=1712609297 1000w" sizes="(max-width: 300px) 100vw, 300px"></a> <figcaption id="caption-attachment-1046" class="wp-caption-text">Histologic section of superficial partial thickness dermal burn in minipig demonstrating blister formation with inflammation and subjacent thermal collagen damage. HE 200x.</figcaption> </figure> <figure id="attachment_1045" aria-describedby="caption-attachment-1045" style="width: 300px" class="wp-caption alignright"> <a href="https://www.compbio.com/images/5017-pig-101-728-1300-g-20x-dermis-HE.jpg?v=1712252464"><img loading="lazy" class="wp-image-1045 size-medium" src="https://www.compbio.com/images/5017-pig-101-728-1300-g-20x-dermis-HE-300x225.jpg?v=1712252496" alt="Thermal Burns and Dermatitis Modeling" width="300" height="225" srcset="https://www.compbio.com/images/5017-pig-101-728-1300-g-20x-dermis-HE-300x225.jpg?v=1712252496 300w, https://www.compbio.com/images/5017-pig-101-728-1300-g-20x-dermis-HE.jpg?v=1712252464 1000w" sizes="(max-width: 300px) 100vw, 300px"></a> <figcaption id="caption-attachment-1045" class="wp-caption-text">Burns and Dermatitis. Histologic section of deep full thickness dermal burn in minipig demonstrating total epithelial loss, deep and severe collagen damage and damage to the underlying adipose tissue. HE 40x.</figcaption> </figure> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling"></h2> <h2 title="Thermal Burn Modeling">Types of Burns and Dermatitis</h2> <ul> <li>Superficial (1st degree)</li> <li>Partial thickness, superficial and deep (2nd degree)</li> <li>Full thickness (3rd degree)</li> <li>Vertical and progression</li> <li>UVB-induced dermal irritation and burns (1st–2nd degree)</li> </ul> <h2 title="Thermal Burn Modeling Therapies">Thermal Burn Modeling Therapies</h2> <ul> <li>Topical or systemic administration</li> <li>Escharotomy and debridement</li> <li>Stem cell therapies</li> <li>Autologous cells</li> <li>Small molecules</li> <li>Biologics</li> <li>Bandaging or wound dressings</li> <li>Sealants</li> <li>Split and full thickness grafting</li> </ul> <p>For more information on our UV burn models, <a href="https://www.compbio.com/files/UV-Light-Study-Presentation-Final-1.pptx?v=1712252661">download our presentation</a>.</p> <h2 title="Thermal Burn Modeling">Thermal Burn Modeling Endpoints</h2> <ul> <li>Wound healing progression</li> <li>OCT</li> <li>Laser Doppler blood flow</li> <li>Draize scoring</li> <li>Transepidermal water loss</li> <li>Digital image analysis of wound size and closure</li> <li>Body temperature</li> <li>Body weights</li> <li>Hematology and clinical chemistry</li> <li>Serum and tissue markers of inflammation</li> <li>Serial biopsies</li> <li>Histopathology and photomicroscopy</li> <li>Special stains and immunohistochemistry</li> <li>Histomorphometry</li> <li>ELISA</li> <li>Custom upon request</li> <li>Complete, timely reporting suitable for regulatory submission (GLP and non-GLP studies)</li> </ul> <p> </p> <p><a href="https://www.compbio.com/files/CBI-Tec-Bulletin-Burn-Modeling.v1.pdf?v=1712253098"><img loading="lazy" class="alignleft wp-image-5417" src="https://www.compbio.com/images/Tec-Bulletin-Header-art.png?v=1712253256" alt="" width="304" height="328" srcset="https://www.compbio.com/images/Tec-Bulletin-Header-art.png?v=1712253256 1961w, https://www.compbio.com/images/Tec-Bulletin-Header-art-278x300.png?v=1712253297 278w, https://www.compbio.com/images/Tec-Bulletin-Header-art-950x1024.png?v=1712253311 950w, https://www.compbio.com/images/Tec-Bulletin-Header-art-768x828.png?v=1712253325 768w, https://www.compbio.com/images/Tec-Bulletin-Header-art-1426x1536.png?v=1712253337 1426w, https://www.compbio.com/images/Tec-Bulletin-Header-art-1901x2048.png?v=1712253423 1901w" sizes="(max-width: 304px) 100vw, 304px"></a></p> <h1 class="entry-title"></h1> <p><a href="https://www.compbio.com/files/CBI-Tec-Bulletin-Burn-Modeling.v1.pdf?v=1712253098"><strong>CHECK OUT OUR ANIMAL MODELS IN BURN RESEARCH  .  PDF FILE</strong></a></p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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