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JCM | December-1 2024 - Browse Articles
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Comment on “Ambrogi et al. Lung Metastasectomy: Where Do We Stand? Results from an Italian Multicentric Prospective Database. J. Clin. Med. 2024, 13, 3106”" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Reply</span></div> <a class="title-link" href="/2077-0383/13/23/7183">Reply to Treasure et al. Comment on “Ambrogi et al. Lung Metastasectomy: Where Do We Stand? Results from an Italian Multicentric Prospective Database. <i>J. Clin. Med.</i> 2024, <i>13</i>, 3106”</a> <div class="authors"> by <span class="inlineblock "><strong>Marcello Carlo Ambrogi</strong>, </span><span class="inlineblock "><strong>Vittorio Aprile</strong>, </span><span class="inlineblock "><strong>Stefano Sanna</strong>, </span><span class="inlineblock "><strong>Sergio Nicola Forti Parri</strong>, </span><span class="inlineblock "><strong>Giovanna Rizzardi</strong>, </span><span class="inlineblock "><strong>Olivia Fanucchi</strong>, </span><span class="inlineblock "><strong>Leonardo Valentini</strong>, </span><span class="inlineblock "><strong>Alberto Italiani</strong>, </span><span class="inlineblock "><strong>Riccardo Morganti</strong>, </span><span class="inlineblock "><strong>Carlotta Francesca Cartia</strong>, </span><span class="inlineblock "><strong>James M. Hughes</strong>, </span><span class="inlineblock "><strong>Marco Lucchi</strong> and </span><span class="inlineblock "><strong>Andrea Droghetti</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7183; https://doi.org/10.3390/jcm13237183 (registering DOI) - 27 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> We would like to express our sincere gratitude for the thoughtful reflections on our recent study regarding pulmonary metastasectomy, and we greatly appreciate the constructive dialog that our work has sparked [...] <a href="/2077-0383/13/23/7183">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Oncology">Oncology</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530262" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1530262" aria-controls="drop-supplementary-1530262" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1530262" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7182/s1?version=1732637600"> Supplementary File 1 (ZIP, 124 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 331 KiB </span> <a href="/2077-0383/13/23/7182/pdf?version=1732637599" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Multimorbidity and COVID-19 Outcomes in the Emergency Department: Is the Association Mediated by the Severity of the Condition at Admission?" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7182">Multimorbidity and COVID-19 Outcomes in the Emergency Department: Is the Association Mediated by the Severity of the Condition at Admission?</a> <div class="authors"> by <span class="inlineblock "><strong>Alberto Catalano</strong>, </span><span class="inlineblock "><strong>Carlotta Sacerdote</strong>, </span><span class="inlineblock "><strong>Marco Alvich</strong>, </span><span class="inlineblock "><strong>Alessandra Macciotta</strong>, </span><span class="inlineblock "><strong>Lorenzo Milani</strong>, </span><span class="inlineblock "><strong>Cinzia Destefanis</strong>, </span><span class="inlineblock "><strong>Kibrom Teklay Gebru</strong>, </span><span class="inlineblock "><strong>Barbara Sodano</strong>, </span><span class="inlineblock "><strong>Lisa Padroni</strong>, </span><span class="inlineblock "><strong>Maria Teresa Giraudo</strong>, </span><span class="inlineblock "><strong>Giovannino Ciccone</strong>, </span><span class="inlineblock "><strong>Eva Pagano</strong>, </span><span class="inlineblock "><strong>Adriana Boccuzzi</strong>, </span><span class="inlineblock "><strong>Valeria Caramello</strong> and </span><span class="inlineblock "><strong>Fulvio Ricceri</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7182; https://doi.org/10.3390/jcm13237182 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Background/Objectives<b>: </b>Charlson Comorbidity Index (CCI) is one of the most reliable indicators to assess the impact of multimorbidity on COVID-19-related outcomes. Moreover, the patient’s clinical conditions are associated with SARS-CoV-2 outcomes. This study aimed to analyze the association between multimorbidity and COVID-19-related <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7182/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Background/Objectives<b>: </b>Charlson Comorbidity Index (CCI) is one of the most reliable indicators to assess the impact of multimorbidity on COVID-19-related outcomes. Moreover, the patient’s clinical conditions are associated with SARS-CoV-2 outcomes. This study aimed to analyze the association between multimorbidity and COVID-19-related outcomes, evaluating whether the National Early Warning Score 2 (NEWS2) mediated these associations. <b>Methods</b><b>: </b>Data were obtained through the platform “EPICLIN”. We analyzed all patients who tested positive for COVID-19 after accessing the emergency department (ED) of San Luigi Gonzaga (Orbassano) and Molinette (Turin) hospitals from 1 March to 30 June 2020. Different outcomes were assessed: non-discharge from the ED, 30-day mortality, ICU admission/death among hospitalized patients, and length of hospitalization among surviving patients. Two subgroups of patients (<65 and 65+ years old) were analyzed using logistic regressions, Cox models, and mediation analyses. <b>Results</b><b>: </b>There was a greater risk of not being discharged or dying among those who were younger and with CCI ≥ 2. Moreover, the higher the CCI, the longer the length of hospitalization. Considering older subjects, a greater CCI was associated with a higher risk of death. Regarding the mediation analyses, multimorbidity significantly impacted the hospitalization length and not being discharged in the younger population. Instead, in the older population, the NEWS2 played a mediation role. <b>Conclusions</b><b>: </b>This research showed that multimorbidity is a risk factor for a worse prognosis of COVID-19. Moreover, there was a strong direct effect of CCI on not being discharged, and the NEWS2 was found to act as mediator in the association between multimorbidity and COVID-19-related outcomes. <a href="/2077-0383/13/23/7182">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Epidemiology_Public_Health">Epidemiology & Public Health</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530238" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 1142 KiB </span> <a href="/2077-0383/13/23/7181/pdf?version=1732636760" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7181">Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction</a> <div class="authors"> by <span class="inlineblock "><strong>Jun Masuda</strong>, </span><span class="inlineblock "><strong>Hideo Wada</strong>, </span><span class="inlineblock "><strong>Takashi Kato</strong>, </span><span class="inlineblock "><strong>Yusuke Tanigaito</strong>, </span><span class="inlineblock "><strong>Koken Hayashi</strong>, </span><span class="inlineblock "><strong>Keita Yamada</strong>, </span><span class="inlineblock "><strong>Keigo Nishida</strong>, </span><span class="inlineblock "><strong>Hiroki Oizumi</strong>, </span><span class="inlineblock "><strong>Toshitaka Kamon</strong>, </span><span class="inlineblock "><strong>Takanobu Ohkubo</strong>, </span><span class="inlineblock "><strong>Karin Okamoto</strong>, </span><span class="inlineblock "><strong>Nobuo Ito</strong>, </span><span class="inlineblock "><strong>Katsuya Shiraki</strong>, </span><span class="inlineblock "><strong>Yuhuko Ichikawa</strong>, </span><span class="inlineblock "><strong>Motomu Shimaoka</strong>, </span><span class="inlineblock "><strong>Kaoru Dohi</strong> and </span><span class="inlineblock "><strong>Hideto Shimpo</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7181; https://doi.org/10.3390/jcm13237181 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Routine activated partial thromboplastin time (APTT) and prothrombin time (PT) measurements do not indicate hypercoagulability in patients with acute myocardial infarction (AMI) and acute cerebral infarction (ACI). <b>Methods</b>: Hypercoagulability in patients with AMI or ACI was evaluated using a clot <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7181/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Routine activated partial thromboplastin time (APTT) and prothrombin time (PT) measurements do not indicate hypercoagulability in patients with acute myocardial infarction (AMI) and acute cerebral infarction (ACI). <b>Methods</b>: Hypercoagulability in patients with AMI or ACI was evaluated using a clot waveform analysis of the APTT or a small amount of tissue factor activation assay (sTF/FIXa). In the CWA, the derivative peak time (DPT), height (DPH), width (DPW), and area the under the curve (AUC) were evaluated. <b>Results</b>: The APTT did not indicate hypercoagulability, but the second DPT of CWA-sTF/FIXa was significantly shorter in patients with ACI than in healthy volunteers (HVs). The first DPH values of CWA-APTT and CWA-sTF/FIXa in patients with ACI and AMI were significantly higher than in HVs. In the receiver operating characteristic (ROC) analyses of ACI or AMI vs. non-thrombosis, the AUC was >0.800 in the DPHs of CWA-APTT and CWA-sTF/FIXa. The AUC of CWA-APTT and CWA-sTF/FIXa in patients with AMI and ACI was significantly higher than in HVs. The AUC/second DPT of CWA-APTT and CWA-sTF/FIXa in patients with AMI and ACI was significantly higher than in HVs. Regarding the ROC analyses of ACI or AMI vs. HVs, the AUC of ROC was higher than 0.800 in the AUC and AUC/second DPT of CWA-APTT and CWA-sTF/FIXa. <b>Conclusions</b>: The AUC/second DPT of CWA-APTT and CWA-sTF/FIXa may be a useful parameter for detecting a hypercoagulable state in patients with AMI and ACI. <a href="/2077-0383/13/23/7181">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Hematology">Hematology</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530228" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 10 pages, 255 KiB </span> <a href="/2077-0383/13/23/7180/pdf?version=1732636526" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Simultaneous Carotid Artery Stenting and Coronary Artery Bypass Grafting in Urgent Patients: A Single Center Experience" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7180">Simultaneous Carotid Artery Stenting and Coronary Artery Bypass Grafting in Urgent Patients: A Single Center Experience</a> <div class="authors"> by <span class="inlineblock "><strong>Mariafrancesca Fiorentino</strong>, </span><span class="inlineblock "><strong>Elisa Mikus</strong>, </span><span class="inlineblock "><strong>Roberto Nerla</strong>, </span><span class="inlineblock "><strong>Diego Sangiorgi</strong>, </span><span class="inlineblock "><strong>Andrea Ruggiero</strong>, </span><span class="inlineblock "><strong>Alberto Tripodi</strong>, </span><span class="inlineblock "><strong>Fausto Castriota</strong> and </span><span class="inlineblock "><strong>Carlo Savini</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7180; https://doi.org/10.3390/jcm13237180 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Coexisting coronary artery disease and critical carotid stenosis present challenges in revascularization, particularly in urgent cases requiring surgery. Combining carotid artery stenting (CAS) with coronary artery bypass grafting (CABG) has gained popularity. <b>Methods</b>: This study analyzed 36 patients who underwent <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7180/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Coexisting coronary artery disease and critical carotid stenosis present challenges in revascularization, particularly in urgent cases requiring surgery. Combining carotid artery stenting (CAS) with coronary artery bypass grafting (CABG) has gained popularity. <b>Methods</b>: This study analyzed 36 patients who underwent simultaneous CAS and CABG from 2014 to 2024. CAS was performed first, with the patient awake for real-time neurocognitive assessment. A clopidogrel loading dose was administered three hours post-surgery. From postoperative day 1, dual antiplatelet therapy was initiated. <b>Results</b>: The median age was 72 years (64–77) and 22.2% were females. The median EuroSCORE II was 2.80 (2.06–3.58). Nine patients (25%) underwent associated procedures. The median cardiopulmonary bypass and cross-clamp times were 66 (54–89) and 51 (41–72) minutes. We observed no in-hospital mortality and no postoperative stroke. The median postoperative bleeding in 24 h was 500 mL and only one (2.8%) patient needed resternotomy for bleeding. The median ventilation time was 9 h (6–12). The median intensive care unit and postoperative length of stay were 2 (2–4) days and 8 (7–11) days, respectively. The median follow-up time was 6 years. Survival at 1, 5, and 10 years was 93.7%, 81.5%, and 60.2%, respectively, while freedom from PTCA/PCI at 1, 5, and 10 years was 100%, 96.7%, and 87.5%, respectively. <b>Conclusions</b>: Simultaneous CAS and CABG is a safe and effective procedure with low in-hospital mortality and morbidity. Our protocol carries a low risk of perioperative stroke. Antiplatelet therapy administration on the day of surgery does not increase the risk of postoperative bleeding. <a href="/2077-0383/13/23/7180">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Cardiovascular_Medicine">Cardiovascular Medicine</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7180/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1530228-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07180/article_deploy/jcm-13-07180-ag.jpg?1732636527" alt="" style="border: 0;"><p>Graphical abstract</p></div></div></div><div id="article-1530228-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07180/article_deploy/jcm-13-07180-ag.jpg?1732636527" title=" <strong>Graphical abstract</strong><br/><strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7180'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530216" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 430 KiB </span> <a href="/2077-0383/13/23/7179/pdf?version=1732636231" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Antifungal Prophylaxis Utilization and the Associated Clinical Outcomes Among Pediatric Patients with Hematological Malignancies or Undergoing Hematopoietic Stem Cell Transplantation" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7179">Antifungal Prophylaxis Utilization and the Associated Clinical Outcomes Among Pediatric Patients with Hematological Malignancies or Undergoing Hematopoietic Stem Cell Transplantation</a> <div class="authors"> by <span class="inlineblock "><strong>Bushra Al Siyabi</strong>, </span><span class="inlineblock "><strong>Juhaina Salim Al-Maqbali</strong>, </span><span class="inlineblock "><strong>Dhanalekshmi Unnikrishnan Meenakshi</strong>, </span><span class="inlineblock "><strong>Yasir Wali</strong> and </span><span class="inlineblock "><strong>Laila Al Yazidi</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7179; https://doi.org/10.3390/jcm13237179 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> Invasive fungal infections (IFIs) are a prevalent complication of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the pediatric population and are associated with high morbidity and mortality. We aimed to identify the utilization of antifungal prophylaxis prescriptions and the associated <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7179/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> Invasive fungal infections (IFIs) are a prevalent complication of intensive chemotherapy and hematopoietic stem cell transplantation (HSCT) in the pediatric population and are associated with high morbidity and mortality. We aimed to identify the utilization of antifungal prophylaxis prescriptions and the associated clinical outcomes. <b>Methods:</b> A retrospective study included children (≤18 years old) diagnosed with hematological malignancies or undergoing HSCT who are at high risk for developing IFI and received systemic antifungal therapy between January 2018 and April 2024 at Sultan Qaboos University Hospital (SQUH), Oman. <b>Results:</b> A powered sample of 222 patients was included, and 208 (93.69%) received antifungal prophylaxis. Among those who received prophylaxis, 148 (66.67%) received appropriate prophylaxis, 86.06% (<i>n</i> = 179) received appropriate dosage. The patients who did not receive antifungal prophylaxis had higher rates of inpatient IFI requiring treatment (85.71% versus 12.02%, <i>p</i> < 0.01), a longer median length of hospital stay (LOS) (67.5 days versus 10 days, <i>p</i> = 0.015), and more incidence of 90-day all-cause mortality (21.43% versus 2.88%, <i>p</i> < 0.01) than those who received antifungal prophylaxis. Survival analysis demonstrated that these patients had a 12% higher risk for earlier death. Also, being on antifungal prophylaxis reduces the odds of inpatient IFI requiring treatment, with an adjusted odds ratio (aOR) of 0.13 [95% CI: 0.019–0.801]. <b>Conclusions:</b> Antifungal prophylaxis utilization was high, and it markedly decreases the occurrence and enhances the prognosis of IFI. Nonetheless, inconsistencies in practice and a lack of pediatric-specific data underscore the necessity for uniform guidelines and additional research to strengthen preventative methods in this population, and proper TDM utilization could provide more robust insights. <a href="/2077-0383/13/23/7179">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Hematology">Hematology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7179/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1530216-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07179/article_deploy/html/images/jcm-13-07179-g001-550.jpg?1732636312" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1530216-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07179/article_deploy/html/images/jcm-13-07179-g001-550.jpg?1732636312" title=" <strong>Figure 1</strong><br/> <p>Kaplan–Meier analysis for the 90-day all-cause mortality classified according to the use of antifungal prophylaxis (N = 222). HR: 0.12, <span class="html-italic">p</span> &lt; 0.01 [95% CI: 0.029–0.477].</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7179'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530153" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 413 KiB </span> <a href="/2077-0383/13/23/7178/pdf?version=1732634468" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Non-Sleep Deep Rest Relaxation and Virtual Reality Therapy for Psychological Outcomes in Patients with Coronary Artery Disease: A Pilot Randomized Controlled Trial" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7178">Non-Sleep Deep Rest Relaxation and Virtual Reality Therapy for Psychological Outcomes in Patients with Coronary Artery Disease: A Pilot Randomized Controlled Trial</a> <div class="authors"> by <span class="inlineblock "><strong>Adam Wrzeciono</strong>, </span><span class="inlineblock "><strong>Błażej Cieślik</strong>, </span><span class="inlineblock "><strong>Pawel Kiper</strong>, </span><span class="inlineblock "><strong>Joanna Szczepańska-Gieracha</strong> and </span><span class="inlineblock "><strong>Robert Gajda</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7178; https://doi.org/10.3390/jcm13237178 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <strong>Background</strong>: While cardiac rehabilitation (CR) primarily focuses on restoring physical strength, preventing relapse, and reducing rehospitalization rates, psychological interventions play a complementary role by supporting mental health, which is crucial for patients’ long-term adherence and overall recovery. The effectiveness of psychological interventions <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7178/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <strong>Background</strong>: While cardiac rehabilitation (CR) primarily focuses on restoring physical strength, preventing relapse, and reducing rehospitalization rates, psychological interventions play a complementary role by supporting mental health, which is crucial for patients’ long-term adherence and overall recovery. The effectiveness of psychological interventions in CR is debated, and while technologies like virtual reality (VR) therapy show promise, they have limitations for patients with coronary artery disease (CAD). Therefore, this study examines non-sleep deep rest (NSDR) relaxation, a novel and easily implementable technique, and compares its impact on depression, anxiety, and stress with VR therapy and standard care. <b>Methods</b>: Forty-five CAD patients undergoing CR in ambulatory conditions were divided into three groups: the NSDR group, which received eight sessions of NSDR relaxation as part of their rehabilitation; the VR group, which received eight sessions of VR therapy as part of their rehabilitation; and the control group, which received standard care including Schultz Autogenic Training (SAT). The outcomes were measured using the Hospital Anxiety and Depression Scale (HADS) and the Perception of Stress Questionnaire (PSQ). <b>Results</b>: Both NSDR relaxation and VR therapy were effective in reducing the HADS total score, anxiety levels, the PSQ general score, and emotional tension. No significant differences were observed between the two treatment approaches. However, SAT was found to be insufficient for effectively improving the mental state of cardiac patients. <b>Conclusion</b><strong>s</strong>: This study suggests that NSDR relaxation is an effective psychotherapeutic intervention in CR. NSDR and VR therapy showed similar benefits, offering promising alternatives to traditional methods. Integrating these techniques could enhance patient outcomes and adherence in CR. Further research is needed to refine these interventions and optimize their clinical application. <a href="/2077-0383/13/23/7178">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/VO2183P338 ">Clinical Advances in Cardiac Rehabilitation (CR)</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530159" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1530159" aria-controls="drop-supplementary-1530159" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1530159" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7177/s1?version=1732634638"> Supplementary File 1 (ZIP, 345 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 1197 KiB </span> <a href="/2077-0383/13/23/7177/pdf?version=1732634637" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Prognostic Value of Baseline Serum Pro-Inflammatory Cytokines in Severe Multisystem Inflammatory Syndrome in Children" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7177">Prognostic Value of Baseline Serum Pro-Inflammatory Cytokines in Severe Multisystem Inflammatory Syndrome in Children</a> <div class="authors"> by <span class="inlineblock "><strong>Anita Bartha-Tatár</strong>, </span><span class="inlineblock "><strong>György Sinkovits</strong>, </span><span class="inlineblock "><strong>János Schnur</strong>, </span><span class="inlineblock "><strong>Veronika Maráczi</strong>, </span><span class="inlineblock "><strong>Máté Dávid</strong>, </span><span class="inlineblock "><strong>Borbála Zsigmond</strong>, </span><span class="inlineblock "><strong>Éva Rimanóczy</strong>, </span><span class="inlineblock "><strong>Balázs Szalay</strong>, </span><span class="inlineblock "><strong>Edina Biró</strong>, </span><span class="inlineblock "><strong>Gabriella Bekő</strong>, </span><span class="inlineblock "><strong>Petra Varga</strong>, </span><span class="inlineblock "><strong>Tamás Szabó</strong>, </span><span class="inlineblock "><strong>Miklós Fagyas</strong>, </span><span class="inlineblock "><strong>Zsolt Fejes</strong>, </span><span class="inlineblock "><strong>János Kappelmayer</strong> and </span><span class="inlineblock "><strong>Béla Nagy Jr.</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7177; https://doi.org/10.3390/jcm13237177 (registering DOI) - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Severe clinical manifestations of multisystem inflammatory syndrome in children (MIS-C) are associated with the dysregulation of immune response following SARS-CoV-2 infection. Therefore, we analyzed the levels of 10 selected cytokines at admission to estimate disease severity and to predict the length of <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7177/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Severe clinical manifestations of multisystem inflammatory syndrome in children (MIS-C) are associated with the dysregulation of immune response following SARS-CoV-2 infection. Therefore, we analyzed the levels of 10 selected cytokines at admission to estimate disease severity and to predict the length of hospitalization. In remission samples, these mediators were followed after intravenous immunoglobulin (IVIG) treatment before discharge. <b>Methods:</b> Thirty-five MIS-C patients at the age of 8.4 ± 4.1 years and 11 clinical controls were included. Acute MIS-C patients were divided into two severity subgroups based on their clinical score determined by the WHO criteria. Serum concentrations of IFN-γ, IL-1α, IL-1RA, IL-8, IL-10, IL-17A, IL-18, IP-10, MCP-1, and TNF-α were measured by MILLIPLEX<sup>®</sup> Human Cytokine/Chemokine panel, while ACE2 activity was determined by a fluorescent kinetic assay. These results were correlated with routinely determined laboratory parameters and clinical characteristics. <b>Results:</b> MIS-C patients demonstrated significantly elevated baseline levels of most of these cytokines compared to controls. Even higher concentrations of IL-18, TNF-α and ferritin with reduced lymphocyte count were found in severe subjects with elevated clinical scores of 4–5 compared to moderate cases with a clinical score of 1–3. Furthermore, the development of cardiovascular dysfunction and prolonged hospitalization (≥8 days) were related to augmented ACE2 and IL-6 levels. IL-18, IL-1RA, IL-10 and TNF-α were diminished in response to IVIG treatment in remission samples. Finally, pre-treatment IL-18 (≥516.8 pg/mL) and TNF-α (≥74.2 pg/mL) effectively differentiated disease severity in MIS-C with AUC values of 0.770 and 0.750, respectively. <b>Conclusions:</b> IL-18 and TNF-α have a prognostic value in disease severity at admission and are capable of monitoring the efficacy of IVIG treatment in MIS-C. <a href="/2077-0383/13/23/7177">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Clinical_Pediatrics">Clinical Pediatrics</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530088" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1530088" aria-controls="drop-supplementary-1530088" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1530088" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7176/s1?version=1732632595"> Supplementary File 1 (ZIP, 787 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 1001 KiB </span> <a href="/2077-0383/13/23/7176/pdf?version=1732632595" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Decoding Chemotherapy Resistance of Undifferentiated Pleomorphic Sarcoma at the Single Cell Resolution: A Case Report" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Case Report</span></div> <a class="title-link" href="/2077-0383/13/23/7176">Decoding Chemotherapy Resistance of Undifferentiated Pleomorphic Sarcoma at the Single Cell Resolution: A Case Report</a> <div class="authors"> by <span class="inlineblock "><strong>Timur I. Fetisov</strong>, </span><span class="inlineblock "><strong>Maxim E. Menyailo</strong>, </span><span class="inlineblock "><strong>Alexander V. Ikonnikov</strong>, </span><span class="inlineblock "><strong>Anna A. Khozyainova</strong>, </span><span class="inlineblock "><strong>Anastasia A. Tararykova</strong>, </span><span class="inlineblock "><strong>Elena E. Kopantseva</strong>, </span><span class="inlineblock "><strong>Anastasia A. Korobeynikova</strong>, </span><span class="inlineblock "><strong>Maria A. Senchenko</strong>, </span><span class="inlineblock "><strong>Ustinia A. Bokova</strong>, </span><span class="inlineblock "><strong>Kirill I. Kirsanov</strong>, </span><span class="inlineblock "><strong>Marianna G. Yakubovskaya</strong> and </span><span class="inlineblock "><strong>Evgeny V. Denisov</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7176; <a href="https://doi.org/10.3390/jcm13237176">https://doi.org/10.3390/jcm13237176</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Undifferentiated pleomorphic sarcoma (UPS) is a highly malignant mesenchymal tumor that ranks as one of the most common types of soft tissue sarcoma. Even though chemotherapy increases the 5-year survival rate in UPS, high tumor heterogeneity frequently leads to chemotherapy resistance and <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7176/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Undifferentiated pleomorphic sarcoma (UPS) is a highly malignant mesenchymal tumor that ranks as one of the most common types of soft tissue sarcoma. Even though chemotherapy increases the 5-year survival rate in UPS, high tumor heterogeneity frequently leads to chemotherapy resistance and consequently to recurrences. In this study, we characterized the cell composition and the transcriptional profile of UPS with resistance to chemotherapy at the single cell resolution. <b>Methods: </b>A 58-year-old woman was diagnosed with a 13.6 × 9.3 × 6.0 cm multi-nodular tumor with heterogeneous cysto-solid structure at the level of the distal metadiaphysis of the left thigh during magnetic resonance tomography. Morphological and immunohistochemical analysis led to the diagnosis of high-grade (G3) UPS. Neoadjuvant chemotherapy, surgery (negative resection margins), and adjuvant chemotherapy were conducted, but tumor recurrence developed. The UPS sample was used to perform single-cell RNA sequencing by chromium-fixed RNA profiling. <b>Results:</b> Four subpopulations of tumor cells and seven subpopulations of tumor microenvironment (TME) have been identified in UPS. The expression of chemoresistance genes has been detected, including <i>KLF4 </i>(doxorubicin and ifosfamide),<i> ULK1</i>,<i> </i><i>LUM</i>, <i>GPNMB</i>, and <i>CAVIN1 </i>(doxorubicin), and <i>AHNAK2 </i>(gemcitabine) in tumor cells and <i>ETS1 </i>(gemcitabine) in TME. <b>Conclusion</b><b>s</b><b>: </b>This study provides the first description of the single-cell transcriptome of UPS with resistance to two lines of chemotherapy, showcasing the gene expression in subpopulations of tumor cells and TME, which may be potential markers for personalized cancer therapy. <a href="/2077-0383/13/23/7176">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Oncology">Oncology</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530070" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 8 pages, 380 KiB </span> <a href="/2077-0383/13/23/7175/pdf?version=1732631978" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Situations in Which Oxytocin Was Administrated by Paramedics in Out-of-Hospital Births: A Retrospective Analysis over Six Years in the Polish Population" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7175">Situations in Which Oxytocin Was Administrated by Paramedics in Out-of-Hospital Births: A Retrospective Analysis over Six Years in the Polish Population</a> <div class="authors"> by <span class="inlineblock "><strong>Hanna Wiciak</strong>, </span><span class="inlineblock "><strong>Mateusz Strózik</strong>, </span><span class="inlineblock "><strong>Adam Smereka</strong>, </span><span class="inlineblock "><strong>Tomasz Fuchs</strong> and </span><span class="inlineblock "><strong>Jacek Smereka</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7175; <a href="https://doi.org/10.3390/jcm13237175">https://doi.org/10.3390/jcm13237175</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Postpartum haemorrhage (PPH) is a leading cause of maternal mortality worldwide, particularly in low- and middle-income countries, complicating 1% to 10% of deliveries. Despite improvement in prevention and management, variations in PPH definitions and measurement methods contribute to challenges in accurately assessing its <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7175/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Postpartum haemorrhage (PPH) is a leading cause of maternal mortality worldwide, particularly in low- and middle-income countries, complicating 1% to 10% of deliveries. Despite improvement in prevention and management, variations in PPH definitions and measurement methods contribute to challenges in accurately assessing its incidence, with up to 90% of PPH-related deaths in high-income countries deemed avoidable through timely intervention. Oxytocin is the primary drug administered during labour or miscarriage, causing an increase in uterine muscle tone, which reduces bleeding and the risk of complications. The aim of the study was to assess the rate of oxytocin use by paramedics for out-of-hospital births in Poland and to verify adherence to WHO-recommended protocols for preventing postpartum haemorrhage in emergency prehospital settings. <b>Methods</b>: We conducted a cross-sectional study using data from the Polish Central System for Emergency Medical Services Missions Monitoring covering all EMS interventions nationwide from 2018 to 2023. The study included cases where oxytocin was administered during EMS interventions for pregnant women, identified through ICD-10 codes (O30–O92), with 62 verified cases meeting the inclusion criteria. <b>Results</b>: Over 6 years, oxytocin was administered in 62 cases when paramedics responded to emergencies involving pregnant women. The mean age of the patients to whom the oxytocin was administered was 29.48 years (SD = 6.25) and ranged from 15 to 43 years. <b>Conclusion</b><b>s</b>: Oxytocin is rarely administered by EMS teams at the prehospital stage. Oxytocin should be considered for incorporation into the set of medications that EMS teams can administer in prehospital settings. There is a need to train EMS teams in the management of pregnancy-related emergencies in accordance with the current medical guidelines. <a href="/2077-0383/13/23/7175">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Obstetrics_Gynecology">Obstetrics & Gynecology</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530061" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 9 pages, 1161 KiB </span> <a href="/2077-0383/13/23/7174/pdf?version=1732631720" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="An Evaluation of a Point-of-Care GEM Premier ChemSTAT Analyzer in an Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7174">An Evaluation of a Point-of-Care GEM Premier ChemSTAT Analyzer in an Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow</a> <div class="authors"> by <span class="inlineblock "><strong>Marina Brailova</strong>, </span><span class="inlineblock "><strong>Marie Audin</strong>, </span><span class="inlineblock "><strong>Julien Raconnat</strong>, </span><span class="inlineblock "><strong>Jean-Baptiste Bouillon-Minois</strong>, </span><span class="inlineblock "><strong>Jeannot Schmidt</strong>, </span><span class="inlineblock "><strong>Bruno Pereira</strong>, </span><span class="inlineblock "><strong>Damien Bouvier</strong> and </span><span class="inlineblock "><strong>Vincent Sapin</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7174; <a href="https://doi.org/10.3390/jcm13237174">https://doi.org/10.3390/jcm13237174</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Having a laboratory renal profile for medical imaging examinations requiring contrast media (CM) administration is strongly advised. Creatinine helps identify patients at risk of contrast-induced nephropathy (CIN). The GEM<sup>®</sup> Premier™ ChemSTAT (Werfen) is a point-of-care (POC) analyzer with 12 emergency parameters, <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7174/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Having a laboratory renal profile for medical imaging examinations requiring contrast media (CM) administration is strongly advised. Creatinine helps identify patients at risk of contrast-induced nephropathy (CIN). The GEM<sup>®</sup> Premier™ ChemSTAT (Werfen) is a point-of-care (POC) analyzer with 12 emergency parameters, including a creatinine assay. This study aims to compare ChemSTAT with the central analytical solution of the University Hospital of Clermont-Ferrand and to evaluate the interest in using POC creatinine in the emergency department (ED) to optimize the flow of patients, especially when CM administration is necessary. <b>Methods:</b> More than 200 whole blood (WB) samples from the ED were evaluated on the ChemSTAT analyzer. As comparative methods, the plasma aliquots from the same samples were assayed on an Atellica<sup>®</sup> CH (Siemens Healthineers). The clinical concordance was assessed according to the decision cut-offs of the French Society of Radiology for the risk of CIN. The availability times of biological results between ChemSTAT and the central laboratory were studied. <b>Results:</b> WB results from the ChemSTAT analyzer correlated well with those from the Atellica<sup>®</sup> CH, except for tCO2 (the known bias between the Siemens and Cobas Roche methods for predicting ChemSTAT values). The results of the creatinine assay allow for identical medical decisions in comparison to the renal-risk cut-offs. The availability of the biological results was reduced by 50 min on average with ChemSTAT vs the central laboratory. Computed tomography (CT) was performed for 44.7% of patients, including the injection of the CM in 68% of cases. For these patients, the availability of creatinine results relative to imaging time is faster with the ChemSTAT by an average of 45.2 min. <b>Conclusions:</b> Great analytical and clinical correlations for creatinine assays allow for the safe identification of patients at risk of CIN, and improve patient flow in ED, especially for those requiring computed tomography with CM. <a href="/2077-0383/13/23/7174">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Nephrology_Urology">Nephrology & Urology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7174/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1530061"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1530061"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1530061" data-cycle-prev="#prev1530061" data-cycle-progressive="#images1530061" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1530061-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g001-550.jpg?1732631789" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1530061" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1530061-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g002-550.jpg?1732631791'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1530061-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g003-550.jpg?1732631792'><p>Figure 3</p></div></script></div></div><div id="article-1530061-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g001-550.jpg?1732631789" title=" <strong>Figure 1</strong><br/> <p>Correlation between the WB samples analyzed on the GEM<sup>®</sup> Premier™ ChemSTAT and the plasma samples analyzed on the Atellica<sup>®</sup> CH for creatinine: (<b>a</b>) linear regression; (<b>b</b>) Bland–Altman difference plots. The red line represents the absolute mean difference (µmol/L). The green lines represent the limit of agreement (±1.96 SD of the differences).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7174'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g002-550.jpg?1732631791" title=" <strong>Figure 2</strong><br/> <p>Correlation between the Atellica<sup>®</sup> CH and the GEM<sup>®</sup> Premier™ ChemSTAT creatinine methods for the eGFR values: (<b>a</b>) linear regression; (<b>b</b>) Bland–Altman plot.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7174'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07174/article_deploy/html/images/jcm-13-07174-g003-550.jpg?1732631792" title=" <strong>Figure 3</strong><br/> <p>Error grid analysis of concordance between eGFR risk stratification using the GEM<sup>®</sup> Premier™ ChemSTAT vs Atellica<sup>®</sup> CH creatinine methods: (<b>a</b>) comparison by a 30 mL/min/1.73 m<sup>2</sup> threshold; (<b>b</b>) comparison by a 45 mL/min/1.73 m<sup>2</sup> threshold.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7174'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1530014" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 18 pages, 672 KiB </span> <a href="/2077-0383/13/23/7173/pdf?version=1732629933" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Surgical Management of Adult Spinal Deformity Patients with Osteoporosis" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7173">Surgical Management of Adult Spinal Deformity Patients with Osteoporosis</a> <div class="authors"> by <span class="inlineblock "><strong>Makeen Baroudi</strong>, </span><span class="inlineblock "><strong>Mohammad Daher</strong>, </span><span class="inlineblock "><strong>Krish Maheshwari</strong>, </span><span class="inlineblock "><strong>Manjot Singh</strong>, </span><span class="inlineblock "><strong>Joseph E. Nassar</strong>, </span><span class="inlineblock "><strong>Christopher L. McDonald</strong>, </span><span class="inlineblock "><strong>Bassel G. Diebo</strong> and </span><span class="inlineblock "><strong>Alan H. Daniels</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7173; <a href="https://doi.org/10.3390/jcm13237173">https://doi.org/10.3390/jcm13237173</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Adult spinal deformity (ASD) commonly affects older adults, with up to 68% prevalence in those over 60, and is often complicated by osteoporosis, which reduces bone mineral density (BMD) and increases surgical risks. Osteoporotic patients undergoing ASD surgery face higher risks of complications <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7173/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Adult spinal deformity (ASD) commonly affects older adults, with up to 68% prevalence in those over 60, and is often complicated by osteoporosis, which reduces bone mineral density (BMD) and increases surgical risks. Osteoporotic patients undergoing ASD surgery face higher risks of complications like hardware failure, pseudoarthrosis, and proximal junctional kyphosis (PJK). Medical management with antiresorptive medications (e.g., bisphosphonates, SERMs, and denosumab) and anabolic agents (e.g., teriparatide, abaloparatide, and romosozumab) can improve BMD and reduce complications. While bisphosphonates reduce fracture risk, teriparatide and newer agents like romosozumab show promise in increasing bone density and improving fusion rates. Surgical adaptations such as consideration of age-adjusted alignment, fusion level selection, cement augmentation, and the use of expandable screws or tethers enhance surgical outcomes in osteoporotic patients. Specifically, expandable screws and cement augmentation have been shown to improve fixation stability. However, further research is needed to evaluate the effectiveness of these treatments, specifically in osteoporotic ASD patients. <a href="/2077-0383/13/23/7173">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Orthopedics">Orthopedics</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529998" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 2618 KiB </span> <a href="/2077-0383/13/23/7172/pdf?version=1732629397" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Sensory Landscape and Embodied Experiences in Anorexia Nervosa Treatment: An Inpatient Sensory Ethnography" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label feature" data-dropdown="drop-article-label-feature" aria-expanded="false">Feature Paper</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7172">The Sensory Landscape and Embodied Experiences in Anorexia Nervosa Treatment: An Inpatient Sensory Ethnography</a> <div class="authors"> by <span class="inlineblock "><strong>Dimitri Chubinidze</strong>, </span><span class="inlineblock "><strong>Elisa Zesch</strong>, </span><span class="inlineblock "><strong>Amanda Sarpong</strong>, </span><span class="inlineblock "><strong>Zhuo Li</strong>, </span><span class="inlineblock "><strong>Claire Baillie</strong> and </span><span class="inlineblock "><strong>Kate Tchanturia</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7172; <a href="https://doi.org/10.3390/jcm13237172">https://doi.org/10.3390/jcm13237172</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Anorexia nervosa (AN) is a complex eating disorder that often requires inpatient care, where treatment experiences are influenced by both the illness and the surrounding environment. Sensory issues in AN are increasingly acknowledged for their impact on treatment engagement and outcomes. <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7172/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Anorexia nervosa (AN) is a complex eating disorder that often requires inpatient care, where treatment experiences are influenced by both the illness and the surrounding environment. Sensory issues in AN are increasingly acknowledged for their impact on treatment engagement and outcomes. Despite this, the ways in which the sensory landscape of inpatient settings shapes patients’ lived experiences and meaning-making processes remain underexplored. <b>Methods</b>: This study employed collaborative sensory ethnography to explore how the sensory environment of an inpatient eating disorder ward shapes patients’ lived experiences. Drawing on multimodal and embodied approaches, a novel proof-of-concept method was developed, combining sensory-attuned guided reflection with AI-assisted visualization. This framework supported patients in exploring and articulating their embodied sensory experiences, linking their emotional and physical states to the ward’s sensory environment through metaphorical reasoning. <b>Results</b>: The findings reveal two central themes: a sense of entrapment within the illness and its treatment, and ambivalence toward both. The study highlights how the sensory environment and spatial layout of the ward amplify these experiences, demonstrating the tension between strict safety protocols and patients’ needs for agency and autonomy. <b>Conclusions</b>: This study illustrates the role of the sensory landscape in shaping treatment experiences and contributing to the broader lived experiences of individuals with AN. The experience of sensory cues in inpatient settings is closely intertwined with contextual and embodied meanings, often evoking complex feelings of entrapment and ambivalence toward both the illness and its treatment. These findings highlight the potential for holistic sensory and spatial adaptations in therapeutic interventions to alleviate such feelings and, consequently, improve patient engagement and well-being. <a href="/2077-0383/13/23/7172">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/BM4H2J13YN ">Eating Disorders: Current Epidemiology and Advances in the Diagnosis and Treatment</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7172/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529998"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529998"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529998" data-cycle-prev="#prev1529998" data-cycle-progressive="#images1529998" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529998-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07172/article_deploy/html/images/jcm-13-07172-g001-550.jpg?1732629477" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529998" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529998-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07172/article_deploy/html/images/jcm-13-07172-g002-550.jpg?1732629479'><p>Figure 2</p></div></script></div></div><div id="article-1529998-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07172/article_deploy/html/images/jcm-13-07172-g001-550.jpg?1732629477" title=" <strong>Figure 1</strong><br/> <p>Frequency of sensory experience color codes assigned to ward spaces by participants.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7172'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07172/article_deploy/html/images/jcm-13-07172-g002-550.jpg?1732629479" title=" <strong>Figure 2</strong><br/> <p>Frequency of sensory experience color codes assigned toward spaces by participants. This figure presents the composite map of the ward, illustrating the spatial distribution of sensory experiences based on the most frequently assigned color codes by participants. Each color represents different levels of sensory sensitivity: red for consistent discomfort, yellow for occasional discomfort, and green for soothing areas. Each color assignment reflects the subjective sensory experiences of participants as they engaged with different ward spaces. The purple line demarcates the separation between patient living spaces and other parts of the ward.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7172'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529936" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 17 pages, 777 KiB </span> <a href="/2077-0383/13/23/7171/pdf?version=1732626781" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="An Observational Study of Evidence-Based Therapies in Older Patients with Heart Failure with Reduced Ejection Fraction: Insights from a Dedicated Heart Failure Clinic" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7171">An Observational Study of Evidence-Based Therapies in Older Patients with Heart Failure with Reduced Ejection Fraction: Insights from a Dedicated Heart Failure Clinic</a> <div class="authors"> by <span class="inlineblock "><strong>Catarina Silva Araújo</strong>, </span><span class="inlineblock "><strong>Irene Marco</strong>, </span><span class="inlineblock "><strong>María Alejandra Restrepo-Córdoba</strong>, </span><span class="inlineblock "><strong>Isidre Vila Costa</strong>, </span><span class="inlineblock "><strong>Julián Pérez-Villacastín</strong> and </span><span class="inlineblock "><strong>Josebe Goirigolzarri-Artaza</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7171; <a href="https://doi.org/10.3390/jcm13237171">https://doi.org/10.3390/jcm13237171</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives: </b>Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), data concerning older patients remain limited. The purpose of this study was to evaluate the implementation of guideline-directed medical therapy (GDMT) in older patients with HFrEF along with <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7171/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives: </b>Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), data concerning older patients remain limited. The purpose of this study was to evaluate the implementation of guideline-directed medical therapy (GDMT) in older patients with HFrEF along with cardiac events and variation in clinical and echocardiographic parameters during follow-up in a heart failure (HF) clinic.<b> Methods: </b>We conducted a retrospective observational analysis of patients with HFrEF aged ≥80 years who attended an HF clinic between March 2022 and February 2023. The primary outcome was a composite of the first episode of worsening HF or cardiovascular death. All-cause death was also recorded. <b>Results:</b> We included 110 patients (30.9% females; mean age 82.9 years). After a median follow-up of 25.5 months, left ventricular ejection fraction (LVEF) improved (mean difference 12.5% (<i>p</i> < 0.001)). New York Heart Association class improved in 37% of patients, and N-terminal pro-B-type natriuretic peptide levels decreased (3091 (158–53354) to 1802 (145–19509), <i>p</i> < 0.001). The primary outcome occurred in 34 patients (30.9%). Patients without the primary outcome were more likely to receive sodium-glucose co-transporter-2 inhibitors (SGLT2i) (23.5% versus 67.1%, <i>p</i> < 0.001) and angiotensin receptor-neprilysin inhibitors, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers (67.6% versus 84.2%, <i>p</i> < 0.05). These patients also received a greater number of GDMT medications (2 (0–4) versus 3 (1–4), <i>p</i> < 0.01) and demonstrated a higher LVEF at the last visit (41.2 ± 10.2% versus 47.1 ± 9.4%, <i>p</i> < 0.05). Survival analysis demonstrated a significant association between LVEF recovery (hazard ratio (HR) 0.35, <i>p</i> < 0.01), treatment with two or more GDMT medications (HR 0.29, <i>p</i> < 0.01), vasodilator use (HR 0.36, <i>p</i> < 0.01), and SGLT2i prescription (HR 0.17, <i>p</i> < 0.001) and a reduced risk of the primary endpoint. <b>Conclusions: </b>The optimization of HF treatment is achievable in older patients and may be associated with a reduction in cardiac events. <a href="/2077-0383/13/23/7171">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/91TCP5E3S2 ">Clinical Management of Patients with Heart Failure</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529898" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1529898" aria-controls="drop-supplementary-1529898" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1529898" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7170/s1?version=1732623677"> Supplementary File 1 (ZIP, 813 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 4017 KiB </span> <a href="/2077-0383/13/23/7170/pdf?version=1732623676" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Differences Between Patients with Probable UIP and Definite UIP on HRCT in Idiopathic Pulmonary Fibrosis: A Real-World Cohort Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7170">Differences Between Patients with Probable UIP and Definite UIP on HRCT in Idiopathic Pulmonary Fibrosis: A Real-World Cohort Study</a> <div class="authors"> by <span class="inlineblock "><strong>Tao Chen</strong>, </span><span class="inlineblock "><strong>Cheng-Sheng Yin</strong>, </span><span class="inlineblock "><strong>Ping Wang</strong>, </span><span class="inlineblock "><strong>Qiu-Hong Li</strong>, </span><span class="inlineblock "><strong>Chi Shao</strong>, </span><span class="inlineblock "><strong>Hui Huang</strong>, </span><span class="inlineblock "><strong>Lan Song</strong>, </span><span class="inlineblock "><strong>Wei-Hong Zhang</strong> and </span><span class="inlineblock "><strong>Zuo-Jun Xu</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7170; <a href="https://doi.org/10.3390/jcm13237170">https://doi.org/10.3390/jcm13237170</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Both a probable usual interstitial pneumonia (UIP) pattern (p-UIP) and a definite UIP pattern (d-UIP) on high-resolution computed tomography (HRCT) are sufficient to establish a diagnosis of idiopathic pulmonary fibrosis (IPF) without the need for a surgical lung biopsy, according to the <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7170/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Both a probable usual interstitial pneumonia (UIP) pattern (p-UIP) and a definite UIP pattern (d-UIP) on high-resolution computed tomography (HRCT) are sufficient to establish a diagnosis of idiopathic pulmonary fibrosis (IPF) without the need for a surgical lung biopsy, according to the 2022 IPF guidelines. However, it remains unknown whether patients with p-UIP and d-UIP have similar disease behaviors and clinical courses. <b>Material and Methods:</b> We retrospectively collected clinical data of patients with IPF and divided the patients into two groups according to their HRCT patterns: a p-UIP group and a d-UIP group. The baseline characteristics, survival rates, and pulmonary function tests were compared between the two groups. The risk factors for mortality were determined by Cox regression in p-UIP and d-UIP separately. <b>Results:</b> There were 304 patients in the p-UIP group and 480 patients in the d-UIP group. Patients in the d-UIP group were more likely to have smoking histories (<i>p</i> < 0.001) and had lower baseline FVC% (74% vs. 77%, <i>p</i> = 0.021) and DLCO% (50% vs. 58%, <i>p</i> < 0.001). Survival rates were higher in p-UIP compared with d-UIP (<i>p</i> = 0.004). There were no differences in changes in FVC% or DLCO% between the two groups. Baseline DLCO% was the only independent risk factor for mortality in p-UIP. Baseline FVC% was independently associated with mortality in d-UIP. Symptom of cough was a risk factor for disease progression (OR = 1.2, <i>p</i> = 0.002) in p-UIP, while symptom of dyspnea might be associated with disease progression in d-UIP (OR = 2.7, <i>p</i> = 0.065). Male patients (OR = 1.88, <i>p</i> = 0.002) with a smoking history (OR = 1.16, <i>p</i> = 0.002) were at higher risk of developing d-UIP. <b>Conclusions:</b> We observed the different disease trajectories between p-UIP and d-UIP. P-UIP on HRCT might identify a subgroup of IPF patients who are in the early stage with a better prognosis. <a href="/2077-0383/13/23/7170">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/25R265G9P4 ">Pulmonary Fibrosis: Therapeutic and Management Strategies</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7170/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529898"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529898"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529898" data-cycle-prev="#prev1529898" data-cycle-progressive="#images1529898" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529898-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g001-550.jpg?1732623819" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529898" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529898-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g002-550.jpg?1732623821'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529898-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g003-550.jpg?1732623824'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529898-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g004-550.jpg?1732623825'><p>Figure 4</p></div></script></div></div><div id="article-1529898-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g001-550.jpg?1732623819" title=" <strong>Figure 1</strong><br/> <p>The flowchart of the study. IPF, idiopathic pulmonary fibrosis; PFT, pulmonary function test; UIP, usual interstitial pneumonia.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7170'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g002-550.jpg?1732623821" title=" <strong>Figure 2</strong><br/> <p>The survival of the different IPF groups. (<b>A</b>) Survival curves of patients with p-UIP and d-UIP. (<b>B</b>) Survival curves of IPF patients with progressive and stable phenotypes. (<b>C</b>) Survival curves of d-UIP patients with progressive and stable phenotypes. (<b>D</b>) Survival curves of p-UIP patients with progressive and stable phenotypes. d-UIP, definite usual interstitial pneumonia; p-UIP, probable usual interstitial pneumonia.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7170'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g003-550.jpg?1732623824" title=" <strong>Figure 3</strong><br/> <p>The changes in pulmonary function parameters in the different groups of IPF (<b>A</b>) The changes in FVC% between d-UIP and p-UIP. (<b>B</b>) The changes in DL<sub>CO</sub>% between d-UIP and p-UIP. (<b>C</b>) The changes in FVC% between progressive IPF and stable IPF. (<b>D</b>) The changes in DL<sub>CO</sub>% between progressive IPF and stable IPF. (<b>E</b>) The changes in FVC% between progressive and stable phenotypes of d-UIP and p-UIP. (<b>F</b>) The changes in DL<sub>CO</sub>% between progressive and stable phenotypes of d-UIP and p-UIP. DL<sub>CO</sub>, diffusing capacity of the lungs for carbon monoxide; d-UIP, definite UIP; FVC, forced vital capacity; p-UIP, probable UIP.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7170'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07170/article_deploy/html/images/jcm-13-07170-g004-550.jpg?1732623825" title=" <strong>Figure 4</strong><br/> <p>Risk factors for progression in p-UIP and d-UIP (<b>A</b>) and developing d-UIP (<b>B</b>). We evaluated the impact of increasing age by 10 years, smoking pack-years by 10, BMI by 5, and cough VAS by 5 units. The bold indicates a statistical significance. BMI, body mass index; DL<sub>CO</sub>, diffusing capacity of the lungs for carbon monoxide; d-UIP, definite usual interstitial pneumonia; FVC, forced vital capacity; p-UIP, probable usual interstitial pneumonia.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7170'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529851" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 989 KiB </span> <a href="/2077-0383/13/23/7169/pdf?version=1732619715" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Marital Stability During the Year After Traumatic Brain Injury in an Ecuadorian Sample: A Repeated-Measures Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7169">Marital Stability During the Year After Traumatic Brain Injury in an Ecuadorian Sample: A Repeated-Measures Study</a> <div class="authors"> by <span class="inlineblock "><strong>Guido Mascialino</strong>, </span><span class="inlineblock "><strong>Paul B. Perrin</strong>, </span><span class="inlineblock "><strong>Juan Carlos Arango-Lasprilla</strong>, </span><span class="inlineblock "><strong>Jack D. Watson</strong>, </span><span class="inlineblock "><strong>Alberto Rodríguez-Lorenzana</strong> and </span><span class="inlineblock "><strong>Clara Paz</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7169; <a href="https://doi.org/10.3390/jcm13237169">https://doi.org/10.3390/jcm13237169</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Traumatic brain injury (TBI) is a major cause of death and disability worldwide and often leads to long-lasting emotional, physical, and cognitive changes and results in reduced functioning across multiple domains. These changes often lead to strain in marital relationships as the <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7169/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Traumatic brain injury (TBI) is a major cause of death and disability worldwide and often leads to long-lasting emotional, physical, and cognitive changes and results in reduced functioning across multiple domains. These changes often lead to strain in marital relationships as the uninjured spouse grapples with adapting to the changes in their partner. <b>Aims:</b> The purpose of this study was to examine the probability of marital stability after TBI at 6 and 12 months following injury (i.e., probability trajectory across those two time points), as well as predictors of that probability trajectory. <b>Methods:</b> The study design was repeated-measures and observational. Patient recruitment and follow-up took place from January 2018 to March 2020 in Quito, Ecuador. Ninety-seven TBI survivors were recruited while hospitalized in the neurosurgery unit of Hospital Eugenio Espejo, a tertiary care center. Patients were assessed at 6 and 12 months after their injury. Hierarchical linear modeling (HLM) was used to examine baseline predictors of linear marital probability trajectories across 6 and 12 months after injury. A final set of HLMs included each of the previously significant predictors from the first model, time, and the interaction terms between time and the previously significant predictor. <b>Results:</b> The first HLM found that marital probability remained stable between 6 and 12 months after TBI. Individuals who were employed at baseline had higher marital probability trajectories than those who had been unemployed. Older individuals had higher marital probability trajectories than younger individuals, and women had higher marital probability trajectories than men. <b>Conclusions:</b> This is the first study to examine marital probability trajectories for an Ecuadorian adult population with TBI, and the data are of great value to understanding post-TBI outcomes in the region. These results can inform interventions and support systems to bolster marital resilience in the aftermath of TBI. Further research is warranted to explore the nuances of these relationships and to validate these findings in diverse populations. <a href="/2077-0383/13/23/7169">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Clinical_Rehabilitation">Clinical Rehabilitation</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7169/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529851"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529851"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529851" data-cycle-prev="#prev1529851" data-cycle-progressive="#images1529851" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529851-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g001-550.jpg?1732619823" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529851" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529851-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g002-550.jpg?1732619825'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529851-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g003-550.jpg?1732619827'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529851-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g004-550.jpg?1732619829'><p>Figure 4</p></div></script></div></div><div id="article-1529851-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g001-550.jpg?1732619823" title=" <strong>Figure 1</strong><br/> <p>Marital probability over time.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7169'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g002-550.jpg?1732619825" title=" <strong>Figure 2</strong><br/> <p>Main effect of employment on marital probability.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7169'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g003-550.jpg?1732619827" title=" <strong>Figure 3</strong><br/> <p>Main effect of age on marital probability.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7169'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07169/article_deploy/html/images/jcm-13-07169-g004-550.jpg?1732619829" title=" <strong>Figure 4</strong><br/> <p>Main effect of gender on marital probability.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7169'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529849" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 660 KiB </span> <a href="/2077-0383/13/23/7168/pdf?version=1732619649" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="A Cross-Sectional Evaluation of Disability in Inflammatory Bowel Disease Using IBD Disk in a Tertiary Center from Romania" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7168">A Cross-Sectional Evaluation of Disability in Inflammatory Bowel Disease Using IBD Disk in a Tertiary Center from Romania</a> <div class="authors"> by <span class="inlineblock "><strong>Oana-Maria Muru</strong>, </span><span class="inlineblock "><strong>Corina Silvia Pop</strong>, </span><span class="inlineblock "><strong>Petruța Violeta Filip</strong>, </span><span class="inlineblock "><strong>Nicoleta Tiucă</strong> and </span><span class="inlineblock "><strong>Laura Sorina Diaconu</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7168; <a href="https://doi.org/10.3390/jcm13237168">https://doi.org/10.3390/jcm13237168</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: The management of inflammatory bowel disease (IBD) includes, besides the control of symptoms, the prevention of organ damage and the improvement of the overall disability. <b>Methods</b>: A single-centered, cross-sectional, non-interventional and population-based study was conducted between October 2023 and August <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7168/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: The management of inflammatory bowel disease (IBD) includes, besides the control of symptoms, the prevention of organ damage and the improvement of the overall disability. <b>Methods</b>: A single-centered, cross-sectional, non-interventional and population-based study was conducted between October 2023 and August 2024 in the Department of Internal Medicine 2 and Gastroenterology of Bucharest Emergency University Hospital to assess the disease disability and quality of life impact using IBD-disk and correlation with different parameters. <b>Results</b>: We included 112 patients; their mean age was 52.35 ± 16.67 years, with a disease duration of 114.9 ± 97.93 months. The majority of patients were represented by men (51.79%). We observed a strong correlation between the CDAI score and overall disability compared to the Mayo score for UC (<i>p</i> = 0.0068). Also, patients with CD and stenotic patterns, as well as the presence of extraintestinal complications, have associated high disability scores. Low hemoglobin levels are associated with high disability (<i>p</i> = 0.0164), while biological treatment is associated with low disability (<i>p</i> = 0.0481). <b>Conclusions</b>: IBD-disk can be used as a valuable tool to assess disability in patients with IBD, also in terms of the activity of the disease, but mostly in terms of the psychological burden of the disease. <a href="/2077-0383/13/23/7168">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/9LY19DI638 ">Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) around the World</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7168/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529849"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529849"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529849" data-cycle-prev="#prev1529849" data-cycle-progressive="#images1529849" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529849-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07168/article_deploy/html/images/jcm-13-07168-g001-550.jpg?1732619754" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529849" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529849-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07168/article_deploy/html/images/jcm-13-07168-g002-550.jpg?1732619756'><p>Figure 2</p></div></script></div></div><div id="article-1529849-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07168/article_deploy/html/images/jcm-13-07168-g001-550.jpg?1732619754" title=" <strong>Figure 1</strong><br/> <p>Gender distribution of the patients with IBD.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7168'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07168/article_deploy/html/images/jcm-13-07168-g002-550.jpg?1732619756" title=" <strong>Figure 2</strong><br/> <p>Main comorbidity distribution of patients with IBD.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7168'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529811" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 277 KiB </span> <a href="/2077-0383/13/23/7167/pdf?version=1732617997" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Fathers as Key Figures Shaping the Foundations of Early Childhood Development: An Exploratory Longitudinal Study on Web-Based Intervention" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7167">Fathers as Key Figures Shaping the Foundations of Early Childhood Development: An Exploratory Longitudinal Study on Web-Based Intervention</a> <div class="authors"> by <span class="inlineblock "><strong>Silvia Cimino</strong>, </span><span class="inlineblock "><strong>Mimma Tafà</strong> and </span><span class="inlineblock "><strong>Luca Cerniglia</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7167; <a href="https://doi.org/10.3390/jcm13237167">https://doi.org/10.3390/jcm13237167</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> Early childhood development is profoundly influenced by parent–child interactions, with recent research emphasizing the crucial role fathers play alongside mothers. Paternal involvement, especially in caregiving activities like feeding, positively impacts children’s cognitive, emotional, and social development. However, paternal depressive symptoms can hinder <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7167/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> Early childhood development is profoundly influenced by parent–child interactions, with recent research emphasizing the crucial role fathers play alongside mothers. Paternal involvement, especially in caregiving activities like feeding, positively impacts children’s cognitive, emotional, and social development. However, paternal depressive symptoms can hinder the quality of these interactions, potentially leading to long-term behavioral and emotional difficulties in children. Despite this, interventions to enhance caregiving quality that target fathers remain limited. This study aimed to evaluate the effectiveness of a web-based video feedback intervention in improving father–child feeding interactions and reducing psychopathological symptoms in both fathers and their 12- to 24-month-old children. <b>Methods:</b> A longitudinal study was conducted with 244 fathers and their young children. Participants were assessed at two time points (T1 and T2) four weeks apart. Fathers engaged in remote one-hour intervention sessions twice a week, based on the Video Intervention Therapy (VIT) approach. The Symptom Checklist-90-Revised (SCL-90-R) assessed the fathers’ psychopathological symptoms, while the Child Behavior Checklist (CBCL 1½–5) evaluated the children’s emotional and behavioral functioning. Father–child feeding interactions were video-recorded and analyzed using the Scala di Valutazione delle Interazioni Alimentari (SVIA). <b>Results:</b> Post-intervention analyses showed significant improvements in father–child feeding interactions, with reductions in maladaptive behaviors and interactive conflicts. Fathers exhibited significant decreases in psychopathological symptoms, particularly in depression, anxiety, and obsessive–compulsive tendencies. Children demonstrated significant reductions in internalizing and externalizing problems. <b>Conclusions:</b> The web-based video feedback intervention effectively enhanced the quality of father–child feeding interactions and reduced psychopathological symptoms in both fathers and children. These findings highlight the importance of supporting fathers in their caregiving roles to promote positive developmental outcomes during critical early childhood periods. Further research is warranted to explore the long-term effects of such interventions and their applicability across diverse populations. <a href="/2077-0383/13/23/7167">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/Y8AXC8ADX6 ">Clinical Practice Guidelines for the Treatment and Management of Peripartum Depression, 2nd Edition</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529782" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 7521 KiB </span> <a href="/2077-0383/13/23/7166/pdf?version=1732617027" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Advances in Cardiac Imaging and Genetic Testing for Diagnosis and Risk Stratification in Cardiomyopathies: 2024 Update" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7166">Advances in Cardiac Imaging and Genetic Testing for Diagnosis and Risk Stratification in Cardiomyopathies: 2024 Update</a> <div class="authors"> by <span class="inlineblock "><strong>Tomasz Gasior</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7166; <a href="https://doi.org/10.3390/jcm13237166">https://doi.org/10.3390/jcm13237166</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Cardiomyopathies represent a diverse group of heart muscle diseases marked by structural and functional abnormalities that are not primarily caused by coronary artery disease. Recent advances in non-invasive imaging techniques, such as echocardiography, cardiac magnetic resonance, and computed tomography, have transformed diagnostic accuracy <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7166/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Cardiomyopathies represent a diverse group of heart muscle diseases marked by structural and functional abnormalities that are not primarily caused by coronary artery disease. Recent advances in non-invasive imaging techniques, such as echocardiography, cardiac magnetic resonance, and computed tomography, have transformed diagnostic accuracy and risk stratification, reemphasizing the role of cardiac imaging in diagnosis, phenotyping, and management of these conditions. Genetic testing complements imaging by clarifying inheritance patterns, assessing sudden cardiac death risk, and informing therapeutic choices. Integrating imaging data, such as left ventricular wall thickness, fibrosis, and apical aneurysms, with genetic findings enhances decision-making for implantable cardioverter-defibrillators in high-risk patients. Emerging technologies like artificial intelligence, strain imaging, and molecular imaging, alongside genetic testing, hold the promise of further refining diagnosis and personalized treatment approaches. This article summarizes the current state and future perspectives of cardiac imaging and genetic testing for diagnosis and risk stratification in cardiomyopathies, offering practical insights for patients’ management. <a href="/2077-0383/13/23/7166">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/7JXJKKE8DN ">Clinical Updates on Cardiomyopathies and Heart Failure</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7166/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529782"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529782"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529782" data-cycle-prev="#prev1529782" data-cycle-progressive="#images1529782" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529782-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g001-550.jpg?1732617121" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529782" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529782-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g002-550.jpg?1732617123'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529782-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g003-550.jpg?1732617125'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529782-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g004-550.jpg?1732617128'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1529782-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g005-550.jpg?1732617129'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1529782-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g006-550.jpg?1732617132'><p>Figure 6</p></div></script></div></div><div id="article-1529782-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g001-550.jpg?1732617121" title=" <strong>Figure 1</strong><br/> <p>Transthoracic echocardiogram in patient with hypertrophic cardiomyopathy. Asymmetric septal hypertrophy.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g002-550.jpg?1732617123" title=" <strong>Figure 2</strong><br/> <p>Longitudinal left ventricular strain assessment in patient with hypertrophic cardiomyopathy. Two-dimensional transthoracic echocardiogram. Moderately reduced strain (−13.9%).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g003-550.jpg?1732617125" title=" <strong>Figure 3</strong><br/> <p>Arrhythmogenic right ventricular cardiomyopathy. Two-dimensional Transthoracic echocardiogram.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g004-550.jpg?1732617128" title=" <strong>Figure 4</strong><br/> <p>Longitudinal left ventricular strain assessment in patient with arrhythmogenic right ventricular cardiomyopathy. Very low right ventricular wall longitudinal strain (−10.8%).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g005-550.jpg?1732617129" title=" <strong>Figure 5</strong><br/> <p><b>Left</b>: Hypertrophic cardiomyopathy with asymmetric septal hypertrophy in cardiac magnetic resonance. Horizontal view. <b>Middle</b>: Arrhythmogenic right ventricular cardiomyopathy in magnetic resonance. Horizontal view. <b>Right</b>: Arrhythmogenic right ventricular cardiomyopathy in cardiac magnetic resonance Sagittal view.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07166/article_deploy/html/images/jcm-13-07166-g006-550.jpg?1732617132" title=" <strong>Figure 6</strong><br/> <p>Cardiac tomography. Hypertrophic cardiomyopathy with large concentric left ventricular hyperthrophy.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7166'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529789" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 9 pages, 519 KiB </span> <a href="/2077-0383/13/23/7165/pdf?version=1732617283" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Hypophosphataemia in Critical Illness: A Narrative Review" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7165">Hypophosphataemia in Critical Illness: A Narrative Review</a> <div class="authors"> by <span class="inlineblock "><strong>Mahesh Ramanan</strong>, </span><span class="inlineblock "><strong>Alexis Tabah</strong>, </span><span class="inlineblock "><strong>Julia Affleck</strong>, </span><span class="inlineblock "><strong>Felicity Edwards</strong>, </span><span class="inlineblock "><strong>Kyle C. White</strong>, </span><span class="inlineblock "><strong>Antony Attokaran</strong> and </span><span class="inlineblock "><strong>Kevin Laupland</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7165; <a href="https://doi.org/10.3390/jcm13237165">https://doi.org/10.3390/jcm13237165</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Phosphate is a predominately intracellular anion that has several key roles in normal cellular functions. Derangements in serum phosphate concentration occur frequently during critical illness, particularly hypophosphataemia, which has been reported in up to 75% of Intensive Care Unit (ICU) patients. The association <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7165/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Phosphate is a predominately intracellular anion that has several key roles in normal cellular functions. Derangements in serum phosphate concentration occur frequently during critical illness, particularly hypophosphataemia, which has been reported in up to 75% of Intensive Care Unit (ICU) patients. The association between hypophosphataemia and ICU outcomes reported in the literature are conflicting and and subject to substantial confounding. Exogenous phosphate can be administered in the ICU using the enteral and intravenous route safely. However, whether administering phosphate and correcting hypophosphataemia results in any patient-centred benefits, or harms, remains uncertain, particularly for patients with mild hypophosphataemia or low-normal phosphate levels. This review will highlight key aspects of hypophosphataemia management in the critically ill, summarise current best practice, and outline major research priorities. <a href="/2077-0383/13/23/7165">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Intensive_Care">Intensive Care</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7165/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529789-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07165/article_deploy/html/images/jcm-13-07165-ag-550.jpg?1732617563" alt="" style="border: 0;"><p>Graphical abstract</p></div></div></div><div id="article-1529789-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07165/article_deploy/html/images/jcm-13-07165-ag-550.jpg?1732617563" title=" <strong>Graphical abstract</strong><br/><strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7165'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529751" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 573 KiB </span> <a href="/2077-0383/13/23/7164/pdf?version=1732615978" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Oncological and Functional Outcomes After Type III Cordectomy for Early Glottic Cancer (Tis, T1a): A Retrospective Study Based on Our 10-Year Experience" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7164">Oncological and Functional Outcomes After Type III Cordectomy for Early Glottic Cancer (Tis, T1a): A Retrospective Study Based on Our 10-Year Experience</a> <div class="authors"> by <span class="inlineblock "><strong>Eleonora Lovati</strong>, </span><span class="inlineblock "><strong>Elisabetta Genovese</strong>, </span><span class="inlineblock "><strong>Livio Presutti</strong>, </span><span class="inlineblock "><strong>Marco Trebbi</strong>, </span><span class="inlineblock "><strong>Luca Pingani</strong>, </span><span class="inlineblock "><strong>Gian Maria Galeazzi</strong>, </span><span class="inlineblock "><strong>Maria Pia Luppi</strong>, </span><span class="inlineblock "><strong>Matteo Alicandri-Ciufelli</strong>, </span><span class="inlineblock "><strong>Daniele Marchioni</strong> and </span><span class="inlineblock "><strong>Maria Consolazione Guarnaccia</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7164; <a href="https://doi.org/10.3390/jcm13237164">https://doi.org/10.3390/jcm13237164</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> The recommended treatment for early glottic cancer is trans-oral laser microsurgery, with excellent oncological and functional outcomes. The aim of this study is to evaluate oncological and functional outcomes in patients who underwent monolateral type III laser cordectomy for early glottic cancer. <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7164/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> The recommended treatment for early glottic cancer is trans-oral laser microsurgery, with excellent oncological and functional outcomes. The aim of this study is to evaluate oncological and functional outcomes in patients who underwent monolateral type III laser cordectomy for early glottic cancer. <b>Methods:</b> A total of 104 patients were enrolled. Staging, histological type, grading, assessment of surgical margins, mean time of relapse, OS, DFS, and DSS were obtained. Maximum phonation time, GIRBAS score, shimmer, jitter, fundamental frequency, and Yanagihara score were evaluated. Patients were submitted to the VHI-10 questionnaire. <b>Results:</b> Correlations between patients with single recurrence and the anterior commissure involvement were analyzed, as well as correlations between patients with recurrence and the status of margins. Correlations between VHI-10 scores and anterior commissure involvement were analyzed. <b>Conclusions:</b> The recurrence rate was higher in patients with anterior commissure involvement. A significant inversely proportional association between DSS and assessment of surgical margins was observed. The distribution of VHI-10 scores differed significatively in patients with and without anterior commissure involvement. Vocal results reflected mild dysphonia. <a href="/2077-0383/13/23/7164">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Otolaryngology">Otolaryngology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7164/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529751"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529751"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529751" data-cycle-prev="#prev1529751" data-cycle-progressive="#images1529751" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529751-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07164/article_deploy/html/images/jcm-13-07164-g001-550.jpg?1732616040" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529751" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529751-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07164/article_deploy/html/images/jcm-13-07164-g002-550.jpg?1732616041'><p>Figure 2</p></div></script></div></div><div id="article-1529751-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07164/article_deploy/html/images/jcm-13-07164-g001-550.jpg?1732616040" title=" <strong>Figure 1</strong><br/> <p>Differences in distribution of patients with a single recurrence and the distribution of patients who underwent extended resection to anterior commissure.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7164'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07164/article_deploy/html/images/jcm-13-07164-g002-550.jpg?1732616041" title=" <strong>Figure 2</strong><br/> <p>Mean values of GIRBAS parameters.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7164'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529750" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1529750" aria-controls="drop-supplementary-1529750" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1529750" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7163/s1?version=1732615973"> Supplementary File 1 (ZIP, 92 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 899 KiB </span> <a href="/2077-0383/13/23/7163/pdf?version=1732615972" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Virtual Reality to Improve Sleep Quality in Patients Suffering from Painful Diabetic Polyneuropathy: A Proof of Concept Study" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label feature" data-dropdown="drop-article-label-feature" aria-expanded="false">Feature Paper</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7163">Virtual Reality to Improve Sleep Quality in Patients Suffering from Painful Diabetic Polyneuropathy: A Proof of Concept Study</a> <div class="authors"> by <span class="inlineblock "><strong>Lisa Goudman</strong>, </span><span class="inlineblock "><strong>Ann De Smedt</strong>, </span><span class="inlineblock "><strong>Julie Jansen</strong>, </span><span class="inlineblock "><strong>Maxime Billot</strong>, </span><span class="inlineblock "><strong>Manuel Roulaud</strong>, </span><span class="inlineblock "><strong>Philippe Rigoard</strong> and </span><span class="inlineblock "><strong>Maarten Moens</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7163; <a href="https://doi.org/10.3390/jcm13237163">https://doi.org/10.3390/jcm13237163</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Sleep disturbance is often observed in the context of chronic pain. We hypothesize that, by providing an immersive Virtual Reality (VR) experience with a serious game to chronic pain patients an hour before bedtime, attention can be diverted from the pain <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7163/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Sleep disturbance is often observed in the context of chronic pain. We hypothesize that, by providing an immersive Virtual Reality (VR) experience with a serious game to chronic pain patients an hour before bedtime, attention can be diverted from the pain condition, consequently leading to improved sleep quality. The aim is to evaluate the efficacy of VR compared to usual care in reducing the number of awakenings during the night and increasing sleep efficiency in patients suffering from painful diabetic polyneuropathy (PDPN). <b>Methods</b>: Eight patients with PDPN were randomized to either two weeks of VR or two weeks of usual care, followed by a cross-over. The primary outcome measurements were sleep efficiency and number of awakenings during the night. As secondary outcomes, self-reported sleep quality, insomnia, pain catastrophizing, anxiety, depression, pain intensity, side effects and impression of change were evaluated. <b>Results</b>: Data of seven patients were analysed. Actigraphy data, self-reported sleep quality, insomnia, pain catastrophizing, anxiety, depression and pain intensity scores did not differ between usual care and VR. As for impression of change, more patients improved after VR compared to usual care (V = 21, <i>p</i> = 0.03). <b>Conclusions</b>: A 2-week period of pain neuroscience education through VR did not result in increased sleep efficiency or fewer awakenings compared to usual care in patients with PDPN. These pilot results indicate that patients subjectively experience an improvement, yet this is not substantiated by either self-reported or objective measurements. <a href="/2077-0383/13/23/7163">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Clinical_Neurology">Clinical Neurology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7163/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529750-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07163/article_deploy/html/images/jcm-13-07163-g001-550.jpg?1732616041" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1529750-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07163/article_deploy/html/images/jcm-13-07163-g001-550.jpg?1732616041" title=" <strong>Figure 1</strong><br/> <p>Study protocol. One baseline visit was conducted after which patients were randomized to either a 2-week period of Virtual Reality or usual care. After this, a cross-over took place to the other intervention. Outcome measurements were collected immediately after each intervention. Abbreviations: PGIC: patient global impression of change; VAS: Visual Analogue Scale; VR: Virtual Reality.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7163'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529664" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 16 pages, 1318 KiB </span> <a href="/2077-0383/13/23/7162/pdf?version=1732614232" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7162">Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts</a> <div class="authors"> by <span class="inlineblock "><strong>Susan J. Ching</strong>, </span><span class="inlineblock "><strong>Apryl Susi</strong>, </span><span class="inlineblock "><strong>Samuel M. Ailsworth</strong>, </span><span class="inlineblock "><strong>Lisa J. Workman</strong>, </span><span class="inlineblock "><strong>Thomas A. E. Platts-Mills</strong>, </span><span class="inlineblock "><strong>Jeffrey M. Wilson</strong> and </span><span class="inlineblock "><strong>Cade M. Nylund</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7162; <a href="https://doi.org/10.3390/jcm13237162">https://doi.org/10.3390/jcm13237162</a> - 26 Nov 2024 </div> Viewed by 39 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with <i>Amblyomma americanum</i> (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndrome (AGS). Longitudinal studies describing risk factors for incident alpha-gal sensitization are lacking. The objective of this project was to <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7162/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with <i>Amblyomma americanum</i> (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndrome (AGS). Longitudinal studies describing risk factors for incident alpha-gal sensitization are lacking. The objective of this project was to assess the incidence of alpha-gal IgE seroconversion and identify associated demographic, occupational, and geographical risk factors among US military personnel. <b>Methods</b>: Samples from the Department of Defense Serum Repository were evaluated at two time points at least 3 years apart. In total, 3000 service members stationed at 10 military installations within the <i>A. americanum</i> tick range were included. Installation, sex, race and ethnicity, rank, military occupation, and branch of service were evaluated. Alpha-gal IgE seroconversion was defined as a change from <0.1 kU/L) to ≥0.1 kU/L. <b>Results</b>: Among the 2821 personnel who were alpha-gal IgE-negative at baseline, 138 (4.9%) seroconverted over a mean interval of 3.4 years. Seroconversion was more frequent in males (5.5% vs. 1.9%), White individuals (6.6% vs. 1.0% in Black people and 1.5% in Hispanics), and individuals in occupations with higher presumed outdoor exposure (e.g., infantry/law enforcement: 12.7% vs. administrative: 1.2%). Differences were not significant between sexes when accounting for military installation/occupation, but differences in race and ethnicity remained significant. <b>Conclusions</b>: This study demonstrates that alpha-gal IgE seroconversion is occurring within the <i>A. americanum</i> tick range and is associated with White race and ethnicity, and occupations with higher outdoor exposure. Further research is needed to elucidate the influence of race and ethnicity on alpha-gal sensitization and develop effective prevention and treatment strategies for AGS. <a href="/2077-0383/13/23/7162">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Epidemiology_Public_Health">Epidemiology & Public Health</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7162/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529664"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529664"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529664" data-cycle-prev="#prev1529664" data-cycle-progressive="#images1529664" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529664-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g001-550.jpg?1732614337" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529664" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529664-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g002-550.jpg?1732614338'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529664-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g003-550.jpg?1732614339'><p>Figure 3</p></div></script></div></div><div id="article-1529664-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g001-550.jpg?1732614337" title=" <strong>Figure 1</strong><br/> <p>Location of military installations in relation to known lone star tick distribution at the time of the blood samples.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7162'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g002-550.jpg?1732614338" title=" <strong>Figure 2</strong><br/> <p>Baseline alpha-gal IgE sensitization of military members compared to measured incidence density of recruits from various installations around the United States. Legend. Map showing alpha-gal IgE sensitization at baseline laboratory testing for military recruits based on member’s home zip code of record at accession compared with the incidence density of alpha-gal IgE at the select military installations demonstrated by the circle size.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7162'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07162/article_deploy/html/images/jcm-13-07162-g003-550.jpg?1732614339" title=" <strong>Figure 3</strong><br/> <p>Alpha-gal IgE levels at second time point in 138 seropositive individuals. Legend: Violin plot on log scale of alpha-gal IgE levels among the 138 positive subjects at the second serum sample. Dark solid lines represent interquartiles of the data. The light dashed lines mark the diagnostic cut-off of the assay (0.1kU/L) and a level of 2 kU/L which has a stronger correlation with clinically symptomatic mammalian meat allergy.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7162'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529719" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 22 pages, 1234 KiB </span> <a href="/2077-0383/13/23/7161/pdf?version=1732615155" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Pathogenesis and Management Strategies in Radioiodine-Refractory Differentiated Thyroid Cancer: From Molecular Mechanisms Toward Therapeutic Approaches: A Comprehensive Review" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7161">Pathogenesis and Management Strategies in Radioiodine-Refractory Differentiated Thyroid Cancer: From Molecular Mechanisms Toward Therapeutic Approaches: A Comprehensive Review</a> <div class="authors"> by <span class="inlineblock "><strong>Iulia-Alexandra Voinea</strong>, </span><span class="inlineblock "><strong>Eugenia Petrova</strong>, </span><span class="inlineblock "><strong>Nicoleta Dumitru</strong>, </span><span class="inlineblock "><strong>Andra Cocoloș</strong>, </span><span class="inlineblock "><strong>Dumitru Ioachim</strong>, </span><span class="inlineblock "><strong>Andrei Liviu Goldstein</strong> and </span><span class="inlineblock "><strong>Adina Mariana Ghemigian</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7161; <a href="https://doi.org/10.3390/jcm13237161">https://doi.org/10.3390/jcm13237161</a> - 26 Nov 2024 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Thyroid cancer (TC) remains the most common cancer in endocrinology. Differentiated thyroid cancer (DTC), the most common type of TC, generally has a favorable outlook with conventional treatment, which typically includes surgery along with radioiodine (RAI) therapy and thyroid-stimulating hormone (TSH) suppression through <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7161/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Thyroid cancer (TC) remains the most common cancer in endocrinology. Differentiated thyroid cancer (DTC), the most common type of TC, generally has a favorable outlook with conventional treatment, which typically includes surgery along with radioiodine (RAI) therapy and thyroid-stimulating hormone (TSH) suppression through thyroid hormone therapy. However, a small subset of patients (less than 5%) develop resistance to RAI. This resistance occurs due to the loss of Na/I symporter (NIS) activity, which is crucial for iodine absorption in thyroid cells. The decline in NIS activity appears to be due to gene modifications, reconfigurations with irregular stimulation of signaling pathways such as MAPK and PI3K/Akt pathways. These molecular changes lead to a diminished ability of DTC cells to concentrate iodine, which makes RAI therapy ineffective. As a consequence, patients with radioiodine-refractory DTC require alternative treatments. Therapy with tyrosine kinase inhibitors (TKIs) has emerged as the primary treatment option to inhibit proliferation and growth of RAIR-DTC, targeting the pathways responsible for tumor progression. In this article, we analyze molecular processes responsible for RAI resistance and explore both conventional and emerging therapeutic strategies for managing RAIR-DTC, aiming to improve patient outcomes. <a href="/2077-0383/13/23/7161">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/9Q60K91C3P ">From Endocrine Tumors Requiring Surgery to Endocrine Issues of Different Surgical Conditions</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7161/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529719"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529719"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529719" data-cycle-prev="#prev1529719" data-cycle-progressive="#images1529719" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529719-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g001-550.jpg?1732615270" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529719" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529719-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g002-550.jpg?1732615271'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529719-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g003-550.jpg?1732615273'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529719-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g004-550.jpg?1732615274'><p>Figure 4</p></div></script></div></div><div id="article-1529719-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g001-550.jpg?1732615270" title=" <strong>Figure 1</strong><br/> <p>MAPK pathway in PTC [<a href="#B29-jcm-13-07161" class="html-bibr">29</a>,<a href="#B30-jcm-13-07161" class="html-bibr">30</a>,<a href="#B59-jcm-13-07161" class="html-bibr">59</a>,<a href="#B60-jcm-13-07161" class="html-bibr">60</a>,<a href="#B61-jcm-13-07161" class="html-bibr">61</a>,<a href="#B62-jcm-13-07161" class="html-bibr">62</a>,<a href="#B63-jcm-13-07161" class="html-bibr">63</a>]. Abbreviations: BRAF—V-Raf mouse sarcoma virus oncogene homologous B1; MEK—mitogen-activated protein kinase/extracellular signal-regulated kinase kinase; MAPK—mitogen-activated protein kinase.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7161'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g002-550.jpg?1732615271" title=" <strong>Figure 2</strong><br/> <p>Treatment approach for advanced/metastatic DTC [<a href="#B1-jcm-13-07161" class="html-bibr">1</a>,<a href="#B28-jcm-13-07161" class="html-bibr">28</a>,<a href="#B30-jcm-13-07161" class="html-bibr">30</a>]. Abbreviations: RAI—radioactive iodine; RAI-avid—radioactive iodine-avid; TKI—tyrosine kinase inhibitor.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7161'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g003-550.jpg?1732615273" title=" <strong>Figure 3</strong><br/> <p>FDA-approved TKIs for RAIR-DTC [<a href="#B112-jcm-13-07161" class="html-bibr">112</a>,<a href="#B121-jcm-13-07161" class="html-bibr">121</a>,<a href="#B123-jcm-13-07161" class="html-bibr">123</a>]. Abbreviations: FDA—Food and Drug Administration; c-MET—hepatocyte growth factor receptor or HGFR; c-KIT—stem cell factor receptor or SCFR; EGFR—epidermal growth factor receptor; FGFR—fibroblast growth factor receptor; FLT3—FMS-like tyrosine kinase 3 (or CD135); PDGFR—platelet-derived growth factor receptor; RET—ret proto-oncogene; RAF—rapidly accelerated fibrosarcoma; VEGFR—vascular endothelial growth factor receptor; DECISION ClinicalTrials.gov number, NCT00984282; SELECT ClinicalTrials.gov number, NCT01321554; COSMIC-311 ClinicalTrials.gov number NCT03690388.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7161'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07161/article_deploy/html/images/jcm-13-07161-g004-550.jpg?1732615274" title=" <strong>Figure 4</strong><br/> <p>Randomized control trial of FDA-approved TKIs for RAIR-DTC [<a href="#B112-jcm-13-07161" class="html-bibr">112</a>,<a href="#B121-jcm-13-07161" class="html-bibr">121</a>,<a href="#B123-jcm-13-07161" class="html-bibr">123</a>]. Abbreviations: FDA—Food and Drug Administration; DECISION ClinicalTrials.gov number, NCT00984282; SELECT ClinicalTrials.gov number, NCT01321554; COSMIC-311 ClinicalTrials.gov number NCT03690388.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7161'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529667" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 1666 KiB </span> <a href="/2077-0383/13/23/7160/pdf?version=1732614274" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Occurrence and Phenotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) in Emergency Medical Service Ambulances as a Potential Threat to Medical Staff and Patients" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7160">Occurrence and Phenotypic Characteristics of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) in Emergency Medical Service Ambulances as a Potential Threat to Medical Staff and Patients</a> <div class="authors"> by <span class="inlineblock "><strong>Piotr Konrad Leszczyński</strong>, </span><span class="inlineblock "><strong>Aleksandra Olędzka</strong>, </span><span class="inlineblock "><strong>Kamila Wierzchowska</strong>, </span><span class="inlineblock "><strong>Aneta Frankowska-Maciejewska</strong>, </span><span class="inlineblock "><strong>Krzysztof Marek Mitura</strong> and </span><span class="inlineblock "><strong>Daniel Celinski</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7160; <a href="https://doi.org/10.3390/jcm13237160">https://doi.org/10.3390/jcm13237160</a> - 26 Nov 2024 </div> Viewed by 48 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Introduction:</b> An ambulance used by an emergency medical service team is the workplace of specialised medical personnel, providing daily transportation for patients in life-threatening conditions, from all walks of life, with numerous diseases and injuries. MRSA (methicillin-resistant <i>Staphylococcus aureus</i>) strains are classified <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7160/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Introduction:</b> An ambulance used by an emergency medical service team is the workplace of specialised medical personnel, providing daily transportation for patients in life-threatening conditions, from all walks of life, with numerous diseases and injuries. MRSA (methicillin-resistant <i>Staphylococcus aureus</i>) strains are classified as Gram-positive cocci, characterised primarily by their multidrug resistance. Infections caused by <i>S. aureus</i> have a low treatment success rate and are associated with persistent carrier state. This study aimed to isolate MRSA and MSSA (methicillin-sensitive <i>Staphylococcus aureus</i>) in the emergency vehicle and determine drug resistance of these isolates. <b>Materials and Methods:</b> This study involved an ambulance vehicle operated in central Poland. A total of 39 swabs were taken and evaluated from inside the ambulance on permanent duty. The isolates were analysed using catalase and coagulase assays, Gram staining, culturing on Chapman medium, growth evaluation on agar with 5% sheep blood, and assessing the strains’ sensitivities to selected antibiotics. Material was collected from 13 designated points located in the medical compartment and driver’s cabin. <b>Results:</b> <i>S. aureus</i> bacteria were detected in 51.28% of the samples, 40% of which were MRSA strains. Despite the application of high disinfection standards for the interior of the ambulance, it was not possible to kill all <i>S. aureus</i> strains, which may be because the pathogens in question produce a biofilm that effectively allows them to survive on various surfaces, including those disinfected. Almost 100% of the MRSA isolates were resistant to antibiotics from the β-lactam group (penicillin, ticarcillin, cefotaxime, and cefoxitin), the macrolide group (erythromycin) and the lincosamide group (clindamycin). However, only a few MRSA strains proved resistant to streptomycin (12.5%) and ciprofloxacin (37.5%). β-lactam antibiotics, such as cefotaxime (100% resistant strains) and penicillin (58% resistant strains), were also ineffective against MSSA. Although MSSA isolates showed slight resistance to ticarcillin and erythromycin (33.3%) and clindamycin (25%), the remaining antibiotics proved effective (no resistant strains). <b>Conclusions:</b> Among the isolated strains, the greatest resistance to β-lactam antibiotics and erythromycin was observed. Multidrug-resistant strains of <i>S. aureus</i> were found in the emergency medical system. Even the MSSA strains detected in the studied ambulance showed resistance to some of the antibiotics used. The prevalence of <i>S. aureus</i> strains within ambulances indicates the need for a high hygiene level in daily prehospital work with patients. <a href="/2077-0383/13/23/7160">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/9219A07NS1 ">Review Special Issue Series: Recent Advances in Epidemiology & Public Health</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7160/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529667"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529667"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529667" data-cycle-prev="#prev1529667" data-cycle-progressive="#images1529667" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529667-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g001-550.jpg?1732614454" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529667" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529667-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g002-550.jpg?1732614455'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529667-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g003-550.jpg?1732614456'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529667-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g004-550.jpg?1732614457'><p>Figure 4</p></div></script></div></div><div id="article-1529667-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g001-550.jpg?1732614454" title=" <strong>Figure 1</strong><br/> <p>CF test. Positive result (<b>A</b>); negative result (<b>B</b>).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7160'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g002-550.jpg?1732614455" title=" <strong>Figure 2</strong><br/> <p>Positive catalase test result.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7160'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g003-550.jpg?1732614456" title=" <strong>Figure 3</strong><br/> <p>Gram-stained Gram-positive cocci.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7160'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07160/article_deploy/html/images/jcm-13-07160-g004-550.jpg?1732614457" title=" <strong>Figure 4</strong><br/> <p>Haemolysis of the strains analysed. α-haemolysis (same strain in two replicates) (<b>A</b>,<b>B</b>); β-haemolysis (<b>C</b>,<b>D</b>).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7160'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529704" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 30 pages, 1034 KiB </span> <a href="/2077-0383/13/23/7159/pdf?version=1732614917" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Epigenetic Biomarkers as a New Diagnostic Tool in Bladder Cancer—From Early Detection to Prognosis" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7159">Epigenetic Biomarkers as a New Diagnostic Tool in Bladder Cancer—From Early Detection to Prognosis</a> <div class="authors"> by <span class="inlineblock "><strong>Natalia Jaszek</strong>, </span><span class="inlineblock "><strong>Alicja Bogdanowicz</strong>, </span><span class="inlineblock "><strong>Jan Siwiec</strong>, </span><span class="inlineblock "><strong>Radosław Starownik</strong>, </span><span class="inlineblock "><strong>Wojciech Kwaśniewski</strong> and </span><span class="inlineblock "><strong>Radosław Mlak</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7159; <a href="https://doi.org/10.3390/jcm13237159">https://doi.org/10.3390/jcm13237159</a> - 26 Nov 2024 </div> Viewed by 17 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Bladder cancer (BC) currently ranks as the 9th most common cancer worldwide. It is characterised by very high rates of recurrence and metastasis. Most cases of BC are of urothelial origin, and due to its ability to penetrate muscle tissue, BC is divided <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7159/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Bladder cancer (BC) currently ranks as the 9th most common cancer worldwide. It is characterised by very high rates of recurrence and metastasis. Most cases of BC are of urothelial origin, and due to its ability to penetrate muscle tissue, BC is divided into non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC). The current diagnosis of BC is still based primarily on invasive cystoscopy, which is an expensive and invasive method that carries a risk of various complications. Urine sediment cytology is often used as a complementary test, the biggest drawback of which is its very low sensitivity concerning the detection of BC at early stages, which is crucial for prompt implementation of appropriate treatment. Therefore, there is a great need to develop innovative diagnostic techniques that would enable early detection and accurate prognosis of BC. Great potential in this regard is shown by epigenetic changes, which are often possible to observe long before the onset of clinical symptoms of the disease. In addition, these changes can be detected in readily available biological material, such as urine or blood, indicating the possibility of constructing non-invasive diagnostic tests. Over the past few years, many studies have emerged using epigenetic alterations as novel diagnostic and prognostic biomarkers of BC. This review provides an update on promising diagnostic biomarkers for the detection and prognosis of BC based on epigenetic changes such as DNA methylation and expression levels of selected non-coding RNAs (ncRNAs), taking into account the latest literature data. <a href="/2077-0383/13/23/7159">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Oncology">Oncology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7159/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529704"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529704"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529704" data-cycle-prev="#prev1529704" data-cycle-progressive="#images1529704" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529704-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07159/article_deploy/html/images/jcm-13-07159-g001-550.jpg?1732615005" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529704" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529704-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07159/article_deploy/html/images/jcm-13-07159-g002-550.jpg?1732615006'><p>Figure 2</p></div></script></div></div><div id="article-1529704-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07159/article_deploy/html/images/jcm-13-07159-g001-550.jpg?1732615005" title=" <strong>Figure 1</strong><br/> <p>Schematic representation of studied changes in methylation status and expression levels of potential diagnostic biomarkers. Green arrows indicate an increase in the expression level and red arrows indicate a decrease in the expression level of a particular ncRNA.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7159'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07159/article_deploy/html/images/jcm-13-07159-g002-550.jpg?1732615006" title=" <strong>Figure 2</strong><br/> <p>Schematic representation of studied changes in methylation status and type of regulation of potential prognostic biomarkers. Green arrows indicate upregulation and red arrows indicate downregulation of a given ncRNA. Red text indicates examples of biomarkers that show both diagnostic and prognostic potential.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7159'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529642" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1529642" aria-controls="drop-supplementary-1529642" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1529642" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7158/s1?version=1732613776"> Supplementary File 1 (ZIP, 191 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 250 KiB </span> <a href="/2077-0383/13/23/7158/pdf?version=1732613776" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Impact of Oxidative Stress on Sperm Quality in Oligozoospermia and Normozoospermia Males Without Obvious Causes of Infertility" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7158">Impact of Oxidative Stress on Sperm Quality in Oligozoospermia and Normozoospermia Males Without Obvious Causes of Infertility</a> <div class="authors"> by <span class="inlineblock "><strong>Linji Chen</strong>, </span><span class="inlineblock "><strong>Yusaku Mori</strong>, </span><span class="inlineblock "><strong>Shogo Nishii</strong>, </span><span class="inlineblock "><strong>Miwa Sakamoto</strong>, </span><span class="inlineblock "><strong>Makoto Ohara</strong>, </span><span class="inlineblock "><strong>Sho-Ichi Yamagishi</strong> and </span><span class="inlineblock "><strong>Akihiko Sekizawa</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7158; <a href="https://doi.org/10.3390/jcm13237158">https://doi.org/10.3390/jcm13237158</a> - 26 Nov 2024 </div> Viewed by 60 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Male factors contribute to approximately 50% of infertile couples. However, obvious causes remain unknown in many cases. This observational study aimed to investigate the associations of clinical and lifestyle parameters with sperm parameters. <b>Methods</b>: This study enrolled 41 men in <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7158/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Male factors contribute to approximately 50% of infertile couples. However, obvious causes remain unknown in many cases. This observational study aimed to investigate the associations of clinical and lifestyle parameters with sperm parameters. <b>Methods</b>: This study enrolled 41 men in infertile couples without obvious causes for male infertility from July 2023 to April 2024. Semen samples were evaluated for sperm number, motility, DNA fragmentation, and oxidative stress (OS) marker oxidation–reduction potential (ORP). Blood samples were analyzed for biochemical parameters, including advanced glycation end products (AGEs), and systemic OS marker diacron-reactive oxygen metabolites (d-ROMs). Skin-accumulated AGE levels were identified with an autofluorescence method. Lifestyle factors were assessed with a lifestyle questionnaire. <b>Results</b>: Most of the participants were under 40 years old and non-obese with normal clinical parameters. Multiple regression analyses revealed that body mass index, serum d-ROMs, and semen ORP levels were independently associated with decreased sperm number. Additionally, serum zinc and semen ORP levels were associated with sperm motility. Furthermore, serum zinc and high-density lipoprotein cholesterol levels were associated with sperm progressive motility and DNA fragmentation, respectively. The rest of the clinical and lifestyle factors, including skin-accumulated and serum AGE levels, were not correlated with any sperm parameters. Furthermore, serum d-ROM and semen ORP levels were not correlated with each other or any of the clinical and lifestyle factors. <b>Conclusions</b>: Our present study indicates that both systemic and local OS may be independently involved in sperm abnormality in healthy men without obvious causes for male infertility. <a href="/2077-0383/13/23/7158">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/70RF05449G ">Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle</a>)<br/> </div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529657" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 1879 KiB </span> <a href="/2077-0383/13/23/7157/pdf?version=1732616414" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Analysis of Dry Needling Combined with an Exercise Program in the Treatment of Knee Osteoarthritis: A Randomized Clinical Trial" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7157">Analysis of Dry Needling Combined with an Exercise Program in the Treatment of Knee Osteoarthritis: A Randomized Clinical Trial</a> <div class="authors"> by <span class="inlineblock "><strong>Aida Agost-González</strong>, </span><span class="inlineblock "><strong>Isabel Escobio-Prieto</strong>, </span><span class="inlineblock "><strong>Cristo Jesús Barrios-Quinta</strong>, </span><span class="inlineblock "><strong>María de los Ángeles Cardero-Durán</strong>, </span><span class="inlineblock "><strong>Luis Espejo-Antúnez</strong> and </span><span class="inlineblock "><strong>Manuel Albornoz-Cabello</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7157; <a href="https://doi.org/10.3390/jcm13237157">https://doi.org/10.3390/jcm13237157</a> - 26 Nov 2024 </div> Viewed by 46 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Therapeutic exercise is recommended for people with knee osteoarthritis (OA), although it could be complemented with other treatments such as dry needling (DN). The purpose of this study was to evaluate and compare the resulting data on pain, functionality, strength and range <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7157/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Therapeutic exercise is recommended for people with knee osteoarthritis (OA), although it could be complemented with other treatments such as dry needling (DN). The purpose of this study was to evaluate and compare the resulting data on pain, functionality, strength and range of motion in subjects with knee osteoarthritis after being treated with a specific therapeutic physical exercise program alone or in combination with the DN technique in the popliteus muscle. <b>Methods</b>: A total of 33 participants were randomly assigned to two groups: the dry needling plus therapeutic physical exercise group (<i>n</i> = 15) and the therapeutic physical exercise alone group (<i>n</i> = 18). Both groups received the same exercise protocol, and the dry-needling group conducted three sessions of this technique over 3 weeks. <b>Results</b>: Variables such as pain, functionality, neuropathic pain, stiffness, strength, range of motion, pain catastrophizing and kinesiophobia were evaluated before and after the intervention, as well as at a follow-up 3 months after the intervention. Significant differences were observed between the two groups in pain intensity, stiffness, functionality, pain catastrophizing and kinesiophobia (<i>p</i> < 0.001). <b>Conclusions</b>: The combination of dry needling targeting the popliteus muscle and therapeutic physical exercise showed better results in terms of pain, functionality and strength compared to therapeutic physical exercise alone, especially after the intervention. <a href="/2077-0383/13/23/7157">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/Musculoskeleta_Pain_Syndromes_Volume_II ">Needling Interventions for the Management of Musculoskeletal Pain Syndromes—Volume II</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7157/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529657"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529657"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529657" data-cycle-prev="#prev1529657" data-cycle-progressive="#images1529657" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529657-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g001-550.jpg?1732616556" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529657" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529657-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g002-550.jpg?1732616558'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529657-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g003-550.jpg?1732616560'><p>Figure 3</p></div></script></div></div><div id="article-1529657-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g001-550.jpg?1732616556" title=" <strong>Figure 1</strong><br/> <p>Image of the simulated puncture procedure and the procedure prior to the DN technique performed.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7157'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g002-550.jpg?1732616558" title=" <strong>Figure 2</strong><br/> <p>Flow chart of participants.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7157'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07157/article_deploy/html/images/jcm-13-07157-g003-550.jpg?1732616560" title=" <strong>Figure 3</strong><br/> <p>Between-group differences in pain intensity perceived along the treatments. ++: <span class="html-italic">p</span> &lt; 0.001.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7157'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529594" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1529594" aria-controls="drop-supplementary-1529594" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1529594" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7156/s1?version=1732612516"> Supplementary File 1 (ZIP, 179 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 15 pages, 1052 KiB </span> <a href="/2077-0383/13/23/7156/pdf?version=1732612516" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Measuring Patient-Reported Outcomes Following Traumatic Craniomaxillofacial Injuries: Development of the AO CMF Injury Symptom Battery" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2077-0383/13/23/7156">Measuring Patient-Reported Outcomes Following Traumatic Craniomaxillofacial Injuries: Development of the AO CMF Injury Symptom Battery</a> <div class="authors"> by <span class="inlineblock "><strong>Sally E. Jensen</strong>, </span><span class="inlineblock "><strong>Nan E. Rothrock</strong>, </span><span class="inlineblock "><strong>Leilani Lacson-Soltysiak</strong>, </span><span class="inlineblock "><strong>Alexis Olsson</strong> and </span><span class="inlineblock "><strong>Edward Ellis</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7156; <a href="https://doi.org/10.3390/jcm13237156">https://doi.org/10.3390/jcm13237156</a> - 26 Nov 2024 </div> Viewed by 86 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> Traumatic craniomaxillofacial (CMF) injuries are associated with various symptoms/concerns that affect patients’ quality of life. The assessment of outcomes from the patient perspective has been limited by the absence of patient-reported outcome (PRO) measures tailored to this patient population. To address this <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7156/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> Traumatic craniomaxillofacial (CMF) injuries are associated with various symptoms/concerns that affect patients’ quality of life. The assessment of outcomes from the patient perspective has been limited by the absence of patient-reported outcome (PRO) measures tailored to this patient population. To address this need, we employed a mixed methods, multi-step process to first identify the most important symptoms/concerns and then use this information to construct a PRO symptom battery. <b>Methods:</b> CMF clinicians and patients who had sustained traumatic CMF injuries participated in semi-structured interviews to elicit the symptoms/concerns considered the most important. The data were analyzed using an iterative coding procedure and symptom/concern frequency was tabulated. The findings were used to develop a conceptual model of the most important symptoms to include in a PRO battery. Existing items were modified as needed and new items were drafted to ensure adequate coverage of the symptoms. <b>Results:</b> The resulting AO CMF Injury Symptom Battery includes four modules specific to the injury site (oral, ocular, nasopharyngeal, ear) and five universal modules (pain/sensation, cognitive, cosmetic, psychosocial, and injury impact). <b>Conclusions:</b> The AO CMF Injury Symptom Battery offers promise for assessing symptoms only patients can report on in clinical research and practice. Ongoing research will examine the battery’s psychometric properties. <a href="/2077-0383/13/23/7156">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/Y45344N736 ">Evidence-Based Medicine in the Practice of Orthopedics and Trauma Care: Current Status and Future Challenges</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7156/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529594"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529594"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529594" data-cycle-prev="#prev1529594" data-cycle-progressive="#images1529594" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529594-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g001-550.jpg?1732612702" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529594" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529594-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g002-550.jpg?1732612703'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529594-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g003-550.jpg?1732612704'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529594-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g004-550.jpg?1732612705'><p>Figure 4</p></div></script></div></div><div id="article-1529594-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g001-550.jpg?1732612702" title=" <strong>Figure 1</strong><br/> <p>Multi-step battery development process.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7156'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g002-550.jpg?1732612703" title=" <strong>Figure 2</strong><br/> <p>AO CMF Injury Symptom Battery conceptual model.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7156'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g003-550.jpg?1732612704" title=" <strong>Figure 3</strong><br/> <p>Example of modifications to candidate items following translatability review.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7156'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07156/article_deploy/html/images/jcm-13-07156-g004-550.jpg?1732612705" title=" <strong>Figure 4</strong><br/> <p>Example of cognitive debriefing findings.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7156'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529553" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 3156 KiB </span> <a href="/2077-0383/13/23/7155/pdf?version=1732611402" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="A Dual Challenge: Coxiella burnetii Endocarditis in a Patient with Familial Thoracic Aortic Aneurysm—Case Report and Literature Review" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2077-0383/13/23/7155">A Dual Challenge: <i>Coxiella burnetii</i> Endocarditis in a Patient with Familial Thoracic Aortic Aneurysm—Case Report and Literature Review</a> <div class="authors"> by <span class="inlineblock "><strong>Alina-Ramona Cozlac</strong>, </span><span class="inlineblock "><strong>Caius Glad Streian</strong>, </span><span class="inlineblock "><strong>Marciana Ionela Boca</strong>, </span><span class="inlineblock "><strong>Simina Crisan</strong>, </span><span class="inlineblock "><strong>Mihai-Andrei Lazar</strong>, </span><span class="inlineblock "><strong>Mirela-Daniela Virtosu</strong>, </span><span class="inlineblock "><strong>Adina Ionac</strong>, </span><span class="inlineblock "><strong>Raluca Elisabeta Staicu</strong>, </span><span class="inlineblock "><strong>Daniela-Carmen Dugaci</strong>, </span><span class="inlineblock "><strong>Adela Emandi-Chirita</strong>, </span><span class="inlineblock "><strong>Ana Lascu</strong>, </span><span class="inlineblock "><strong>Dan Gaita</strong> and </span><span class="inlineblock "><strong>Constantin-Tudor Luca</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7155; <a href="https://doi.org/10.3390/jcm13237155">https://doi.org/10.3390/jcm13237155</a> - 26 Nov 2024 </div> Viewed by 57 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Thoracic aortic aneurysms (TAAs) are potentially life-threatening medical conditions, and their etiology involves both genetic and multiple risk factors. <i>Coxiella burnetii</i> endocarditis is one of the most frequent causes of blood culture-negative infective endocarditis (BCNIE) in patients with previous cardiac surgery. <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7155/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Thoracic aortic aneurysms (TAAs) are potentially life-threatening medical conditions, and their etiology involves both genetic and multiple risk factors. <i>Coxiella burnetii</i> endocarditis is one of the most frequent causes of blood culture-negative infective endocarditis (BCNIE) in patients with previous cardiac surgery. Our review aims to emphasize the importance of genetic testing in patients with thoracic aortic aneurysms but also the importance of additional testing in patients with suspected endocarditis whose blood cultures remain negative. The reported case has a history of acute DeBakey type I aortic dissection that developed during her second pregnancy, for which the Bentall procedure was performed at that time. Ten years after the surgery, the patient started developing prolonged febrile syndrome with repeatedly negative blood cultures, the serological tests revealing the presence of an infection with <i>Coxiella burnetii</i>. Considering her family history and the onset of her aortic pathology at a young age, genetic tests were performed, disclosing a missense variant in the actin alpha-2 (<i>ACTA2</i>) gene in heterozygous status. <b>Methods</b>: For a better understanding of both conditions, our research was conducted in two directions: one reviewing the literature on patients with <i>Coxiella burnetii</i> BCNIE and the other focusing on patients who had a familial thoracic aortic aneurysm (FTAA) due to the <i>ACTA2</i> variant. This review incorporates studies found on PubMed and ResearchGate up to August 2024. <b>Conclusions</b>: BCNIE represents a condition with several diagnostic challenges and may lead to severe complications if timely treatment is not initiated. Also, diagnosing an FTAA requires genetic testing, enabling better follow-up and management. <a href="/2077-0383/13/23/7155">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jcm/special_issues/91TCP5E3S2 ">Clinical Management of Patients with Heart Failure</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7155/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529553"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529553"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529553" data-cycle-prev="#prev1529553" data-cycle-progressive="#images1529553" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529553-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g001-550.jpg?1732611478" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529553" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529553-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g002-550.jpg?1732611481'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529553-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g003-550.jpg?1732611482'><p>Figure 3</p></div></script></div></div><div id="article-1529553-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g001-550.jpg?1732611478" title=" <strong>Figure 1</strong><br/> <p>(<b>A</b>) Transthoracic and (<b>B</b>) transesophageal echocardiographies showing an echo-dense mass surrounding the ascending aorta.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7155'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g002-550.jpg?1732611481" title=" <strong>Figure 2</strong><br/> <p>Thorax CT scan images showing the periaortic fluid accumulation (red arrow): (<b>A</b>) sagittal and (<b>B</b>) axial sections.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7155'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07155/article_deploy/html/images/jcm-13-07155-g003-550.jpg?1732611482" title=" <strong>Figure 3</strong><br/> <p>Intraoperative images showing the periaortic fluid accumulation (black arrow).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7155'>Full article</a></strong> "></a></div> </div> </div> <div class="generic-item article-item"> <input class="article-list-checkbox export-element" type="checkbox" name="articles_ids[]" value="1529538" data-select-all-name="article-listing"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1529538" aria-controls="drop-supplementary-1529538" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1529538" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2077-0383/13/23/7154/s1?version=1732611079"> Supplementary File 1 (ZIP, 836 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 21 pages, 2696 KiB </span> <a href="/2077-0383/13/23/7154/pdf?version=1732611078" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Non-Invasive Strategies for Remineralization and Hypersensitivity Management in Molar–Incisor Hypomineralization—A Systematic Review and Meta-Analysis" data-journal="jcm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Systematic Review</span></div> <a class="title-link" href="/2077-0383/13/23/7154">Non-Invasive Strategies for Remineralization and Hypersensitivity Management in Molar–Incisor Hypomineralization—A Systematic Review and Meta-Analysis</a> <div class="authors"> by <span class="inlineblock "><strong>Bianca Golzio Navarro Cavalcante</strong>, </span><span class="inlineblock "><strong>Éva Mlinkó</strong>, </span><span class="inlineblock "><strong>Bence Szabó</strong>, </span><span class="inlineblock "><strong>Brigitta Teutsch</strong>, </span><span class="inlineblock "><strong>Péter Hegyi</strong>, </span><span class="inlineblock "><strong>János Vág</strong>, </span><span class="inlineblock "><strong>Orsolya Németh</strong>, </span><span class="inlineblock "><strong>Gábor Gerber</strong> and </span><span class="inlineblock "><strong>Gábor Varga</strong></span> </div> <div class="color-grey-dark"> <em>J. Clin. Med.</em> <b>2024</b>, <em>13</em>(23), 7154; <a href="https://doi.org/10.3390/jcm13237154">https://doi.org/10.3390/jcm13237154</a> - 26 Nov 2024 </div> Viewed by 67 <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Molar–incisor hypomineralization (MIH) is an enamel defect affecting molars and incisors, often leading to hypersensitivity, enamel breakdown, and increased caries risk. Non-invasive treatments, such as casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and fluoride varnish, show potential in remineralizing affected enamel and reducing sensitivity, <a href="#" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7154/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Molar–incisor hypomineralization (MIH) is an enamel defect affecting molars and incisors, often leading to hypersensitivity, enamel breakdown, and increased caries risk. Non-invasive treatments, such as casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and fluoride varnish, show potential in remineralizing affected enamel and reducing sensitivity, but their efficacy is still debated. This study systematically reviews and analyzes the effectiveness of CPP-ACP and other non-invasive agents in improving remineralization and reducing hypersensitivity in MIH-affected teeth. <b>Methods:</b> A systematic search was conducted on PubMed, Embase, and Central in July 2024, including interventional and observational studies on remineralization and hypersensitivity in pediatric MIH patients (<18 years). A total of 1566 studies were found, with 15 included in the meta-analysis. A random-effects model was applied, including subgroup analysis by lesion severity. <b>Results:</b> CPP-ACP showed no statistically significant advantage over fluoride in remineralization (MD −3.80, 95% CI: −8.57; 0.98), but it significantly reduced hypersensitivity compared to fluoride varnish (MD −2.36, 95% CI: −3.83; −0.89). Although this reduction in hypersensitivity may be clinically relevant, the high heterogeneity (I² = 83%) and wide confidence intervals limit the reliability of these findings. <b>Conclusions:</b> CPP-ACP has a moderate effect in reducing hypersensitivity but does not outperform fluoride in remineralization. Other agents, such as calcium glycerophosphate and silver diamine fluoride, showed mild benefits. The current evidence base is limited and heterogeneous, highlighting the need for high-quality, long-term studies to confirm these findings and guide MIH management. <a href="/2077-0383/13/23/7154">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jcm/sections/Dentistry_Oral_Surgery_Oral_Medicine">Dentistry, Oral Surgery and Oral Medicine</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2077-0383/13/23/7154/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1529538"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1529538"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1529538" data-cycle-prev="#prev1529538" data-cycle-progressive="#images1529538" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1529538-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g001-550.jpg?1732611205" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1529538" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1529538-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g002-550.jpg?1732611207'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1529538-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g003-550.jpg?1732611211'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1529538-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g004-550.jpg?1732611212'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1529538-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g005-550.jpg?1732611216'><p>Figure 5</p></div></script></div></div><div id="article-1529538-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g001-550.jpg?1732611205" title=" <strong>Figure 1</strong><br/> <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart showing the selection process.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7154'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g002-550.jpg?1732611207" title=" <strong>Figure 2</strong><br/> <p>Forest plot comparing the CPP-ACP vs. fluoride-based groups, using the change from baseline LF values of mild and severe MIH lesions for remineralization [<a href="#B49-jcm-13-07154" class="html-bibr">49</a>,<a href="#B50-jcm-13-07154" class="html-bibr">50</a>,<a href="#B51-jcm-13-07154" class="html-bibr">51</a>].</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7154'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g003-550.jpg?1732611211" title=" <strong>Figure 3</strong><br/> <p>Forest plot presenting the mean change from baseline LF values with different agents used for the remineralization of mild and severe MIH lesions [<a href="#B49-jcm-13-07154" class="html-bibr">49</a>,<a href="#B50-jcm-13-07154" class="html-bibr">50</a>,<a href="#B52-jcm-13-07154" class="html-bibr">52</a>,<a href="#B53-jcm-13-07154" class="html-bibr">53</a>,<a href="#B54-jcm-13-07154" class="html-bibr">54</a>].</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7154'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g004-550.jpg?1732611212" title=" <strong>Figure 4</strong><br/> <p>Forest plot comparing the CPP-ACP vs. fluoride varnish groups by changes in hypersensitivity compared to baseline, measured by the VAS pain scale (0 to 10), for MIH lesions [<a href="#B56-jcm-13-07154" class="html-bibr">56</a>,<a href="#B57-jcm-13-07154" class="html-bibr">57</a>].</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7154'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jcm/jcm-13-07154/article_deploy/html/images/jcm-13-07154-g005-550.jpg?1732611216" title=" <strong>Figure 5</strong><br/> <p>(<b>a</b>) Forest plot presenting CPP-ACP (subgroups by CPP-ACP type): mean change from baseline values for hypersensitivity measured on the VAS pain scale (0 to 10). (<b>b</b>) Forest plot presenting fluoride varnish (subgroups by FV): mean change from baseline values for hypersensitivity measured on the VAS pain scale (0 to 10) [<a href="#B56-jcm-13-07154" class="html-bibr">56</a>,<a href="#B57-jcm-13-07154" class="html-bibr">57</a>,<a href="#B58-jcm-13-07154" class="html-bibr">58</a>,<a href="#B59-jcm-13-07154" class="html-bibr">59</a>,<a href="#B60-jcm-13-07154" class="html-bibr">60</a>].</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2077-0383/13/23/7154'>Full article</a></strong> "></a></div> </div> </div> <span class="more" style="display: none;"></span> </div> <div class="row footer"> <div class="listing-select-options"> <div class="columns small-12"> <div class="select generic-item"> <a href="#" class="export-options-show export-element export-expanded"> Show export options <i class="material-icons">expand_more</i> </a> <a href="#" class="export-options-show export-element"> Show export options <i class="material-icons">expand_less</i> </a> </div> <div class="listing-export-options export-element"> <div class="export-element" style="margin-top: 10px; margin-bottom: 10px;"> <input type="checkbox" class="selector selectUnselectAll bb-checkbox" id="selectUnselectAll" data-select-all="article-listing"> <div class="indented bb-indented"> Select all </div> </div> <div class="indented1"> <span style="display: inline-block; margin-right: 15px; margin-bottom: 10px;">Export citation of selected articles as:</span> <br class="show-for-medium-down" /> <div class="listing-export"> <select class="chosen-select inline" name="format_bottom"> <option value="plaintext"> Plain Text </option> <option value="bibtex"> BibTeX </option> <option value="bibtex_no_abstract"> BibTeX (without abstracts) </option> <option value="endnote"> Endnote </option> <option value="endnote_no_abstract"> Endnote (without abstracts) </option> <option value="tab_delimited"> Tab-delimited </option> <option value="ris"> RIS </option> </select> </div> <input type="submit" value="Export" class="articleBrowserSubmit button button--color-inversed" id="articleBrowserExport_bottom"> </div> <div style="border-top: 1px solid #ededed; height: 5px; margin-top: 15px;"> </div> </div> <a id="link-export-modal-nothing-selected" data-reveal-id="export-modal-nothing-selected" style="display: none;"></a> <div id="export-modal-nothing-selected" class="reveal-modal reveal-modal-new reveal-modal-new--small" data-reveal aria-labelledby="modalTitle" aria-hidden="true" role="dialog"> <div class="row"> <div class="small-12 columns"> <h2>Error</h2> Oops... you haven't selected anything for export. </div> <div class="small-12 columns"> <a class="button button--color" onclick="$(this).closest('.reveal-modal-new').foundation('reveal', 'close'); return false;">Ok</a> </div> </div> <a class="close-reveal-modal" aria-label="Close"> <i class="material-icons">clear</i> </a> </div> </div> <div> <div class="columns large-12 medium-12 small-12"> Displaying articles 1-183 </div> <div style="clear: both"></div> </div> </div> </div> </div> </form> </div> <div class="content__container content__container__combined-for-large content__container__combined-for-large__last show-for-small"> <div class="row"> <div class="small-6 columns text-left"> Previous Issue <div><a href="/2077-0383/13/22">Volume 13, November-2</a></div> </div> <div class="small-6 columns text-right"> </div> </div> </div> <div id="metrics-modal2" class="reveal-modal reveal-modal-new" data-reveal aria-labelledby="Captcha" aria-hidden="true" role="dialog"> <div class="row row-smallh3"> <div class="small-12 columns"> <h2>Issue View Metrics</h2> </div> <div class="small-12 columns"> <div id="issue_stats_div" style="margin-bottom: 1em;"> <div id="issue_stats_swf"></div> <div class="info-box"> Multiple requests from the same IP address are counted as one view. </div> </div> </div> </div> <a class="close-reveal-modal" aria-label="Close"> <i class="material-icons">clear</i> </a> </div> </div> </div> </div> </div> </section> <div id="footer"> <div class="journal-info"> <span> <em><a class="Var_JournalInfo" href="/journal/jcm">J. 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