Sprifermin - Merck - AdisInsight

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<a class="back-to-profile" style="display:block"></a> <h3 class="profile-sticky-bar__title" id="cell-drugName"> Sprifermin - Merck </h3> </div> <div class="next-prev-container"> <a class="next-profile"> Next </a> <a class="prev-profile"> Previous </a> </div> <div class="profile-sticky-bar__cell profile-sticky-bar__cell--cell-b"> <button class="profile-sticky-bar__btn-toc-popup" id="toc-menu-btn" type="button"> Table of Contents </button> <div class="tree-clone__table-of-contents" id="profile-sticky-bar__toc"> <ul class="table-of-contents__section-list section-list--first-level"> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="At a glance"> At a glance </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Development Overview"> Development Overview </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Introduction"> Introduction </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Company agreements"> Company agreements </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Key development milestones"> Key development milestones </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Patent information"> Patent information </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Drug Properties & Chemical Synopsis"> Drug Properties & Chemical Synopsis </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Biomarker"> Biomarker </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Trial Landscape"> Trial Landscape </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Development Status"> Development Status </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Summary Table"> Summary Table </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Commercial Information"> Commercial Information </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Involved Organisations"> Involved Organisations </a> </li> <li class="table-of-contents__section-item section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Credit Suisse Market Status"> Credit Suisse Market Status </a> </li> <li class="table-of-contents__section-item section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Credit Suisse Financial Forecast"> Credit Suisse Financial Forecast </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Scientific Summary"> Scientific Summary </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Adverse events"> Adverse events </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Pharmacodynamics"> Pharmacodynamics </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Therapeutic trials"> Therapeutic trials </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Development History"> Development History </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="References"> References </a> </li> </ul> </div> </div> </div> <div id="overlay"> <div class="overlay-section"> <div class="wrapper"> <div class="row closeSectionRow"> <div 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class="publication-title"> <span></span> Drug Profile </div> </div> <h1 class="document__title hotspot-element" id="drugNameID"> Sprifermin - Merck </h1> <span class="document__alt-name"> <strong>Alternative Names:</strong> AS-902330; FGF-18; rhFGF-18; Zfgf5 </span> <p class="document__latest-update">Latest Information Update: 01 Jan 2024</p> <div class="profile_price"> <span class="price_val"> Price : </span> <span> €55 </span> <sup>*</sup> </div>  <div class="button__buy-profile"> <form class="default-form" method="POST" action="/payment" data-track="form_submission" data-track-value="Sprifermin - Merck" data-track-context="Pay Per View - drugs"> <input type="hidden" name="contentType" value="drugs"/> <input type="hidden" name="profileId" value="800017598"/> <input type="hidden" name="profileSubTitle" value="Sprifermin - Merck"/> <button class="btn btn-primary buy-drugprofile-btn" type="submit">Buy Profile</button> </form> </div> <div class="buy_btn_message"> <ul> <li> Adis is an information provider. <strong>We do not sell or distribute actual drugs.</strong> </li> <li> Final gross price and currency may vary according to local VAT and billing address. </li> <li> Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase. </li> <li> A link to download a PDF version of the drug profile will be included in your email receipt. </li> </ul> </div> </div> <div class="layout__col-aside" role="complementary"> </div> </div> <div class="layout-3 at-a-glance-section"> <div class="layout__col-main" role="main"> <div class="document__section section--at-a-glance" id="at-a-glance"> <input id="drug_id" class="hidden" type="hidden" value="800017598"/> <h2 class="section__heading heading-sticky" id="at-a-glance-title"> At a glance </h2> <div class="section__content"> <div class="data-list data-list--properties-column"> <ul class="data-list__content"> <li class="data-list__property" id="at-a-glance_origniator"> <strong class="data-list__property-key"> Originator </strong> <span class="data-list__property-value"> ZymoGenetics </span> </li> <li class="data-list__property" id="at-a-glance_developer"> <strong class="data-list__property-key"> Developer </strong> <span class="data-list__property-value"> Merck Serono; Molecular Therapeutics; Nordic Bioscience; Pfizer </span> </li> <li class="data-list__property" id="at-a-glance_class"> <strong class="data-list__property-key"> Class </strong> <span class="data-list__property-value"> Fibroblast growth factors; Neuroprotectants </span> </li> <li class="data-list__property" id="at-a-glance_mechanismOfAction"> <strong class="data-list__property-key"> Mechanism of Action </strong> <span class="data-list__property-value"> Fibroblast growth factor stimulants </span> </li> </ul> <ul class="data-list__content" id="at-a-glance_orphanStatus"> <li class="data-list__property"> <strong class="data-list__property-key show-tooltip"> <span> Orphan Drug Status <div class="tooltip-information"> <strong></strong> <p> Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases. </p> </div> </span> </strong> <span class="data-list__property-value"> No </span> </li> <li class="data-list__property" id="at-a-glance_newMolecularEntity"> <strong class="data-list__property-key"> New Molecular Entity </strong> <span class="data-list__property-value"> Yes </span> </li> </ul> <h3 class="data-list__heading" id="at-a-glance_highestDevPhases"> Highest Development Phases </h3> <ul class="data-list__content data-list__content--highest-dev-phases"> <li class="data-list__property"> <strong class="data-list__property-key"> Phase II </strong> <span class="data-list__property-value"> Osteoarthritis </span> </li> <li class="data-list__property"> <strong class="data-list__property-key"> Discontinued </strong> <span class="data-list__property-value"> Cartilage disorders; Stroke </span> </li> </ul> <h3 class="data-list__heading" id="at-a-glance_mostRecentEvents"> Most Recent Events </h3> <ul class="data-list__content data-list__content--most-recent-events"> <li class="data-list__property"> <strong class="data-list__property-key">10 Nov 2023</strong> <span class="data-list__property-value property-value--event-details"> Efficacy data from the FORWARD phase II trial in Osteoarthritis presented at the ACR Convergence 2023 <REF id="803842601" /> </span> </li> <li class="data-list__property"> <strong class="data-list__property-key">10 Jan 2022</strong> <span class="data-list__property-value property-value--event-details"> Sprifermin licensed to Trialspark worldwide <REF id="809347273" /> </span> </li> <li class="data-list__property"> <strong class="data-list__property-key">15 Apr 2021</strong> <span class="data-list__property-value property-value--event-details"> Sprifermin is still in phase II FORWARD trial for Osteoarthritis in Argentina, Czech Republic, Estonia, Denmark, Hong Kong, Poland, Romania and USA (Intra-articular) (NCT01919164) </span> </li> </ul> </div> </div> </div> <div class="restrictive-access"> <div class="restrictive-access__message"> <h4 class="restrictive-access__heading"> You need to be a logged in or subscribed to view this content <a class="btn btn-primary freeTrialButton" href="https://www.springernature.com/gp/librarians/licensing/agc/request-a-demo" target="_blank" data-track="call_to_action" data-track-context="search-results" data-track-value="Request demo">Request demo</a> </h4> <div class="restrictive-access__desc"> <span id="invalid-subscription" class="message-desc"> If your organization or you do not have a subscription, try one of the following: </span> <ul class="no-subscription"> <li> Contacting your organization’s admin about adding this content to your AdisInsight subscription </li> <li> Buying a PDF version of any individual profile </li> <li> <a class="freeTrialButton" href="https://www.springernature.com/gp/librarians/licensing/agc/request-a-trial" target="_blank" data-track="call_to_action" data-track-context="search-results" data-track-value="Request a free Trial">Request a free trial</a> </li> </ul> <span id="valid-subscription" class="message-desc"> If your organization has a subscription, there are several access options, even while working remotely: </span> <ul class="no-subscription"> <li> Working within your organization’s network </li> <li> <a id="login-link" class="login-access-link" href="https://idp.springer.com/auth/personal/springernature">Login</a> with username/password or try to <a id="login-link" class="login-access-link" href="https://wayf.springernature.com">access</a> via your institution </li> <li> Persisted access using your organization’s identifier stored in your user browser for 90 days </li> </ul> <span class="contact__email"> For assistance, contact us at <a href="mailto:asktheexpert.adisinsight@springer.com">asktheexpert.adisinsight@springer.com</a> </span> </div> </div> </div> </div> <div class="layout__col-aside" role="complementary" hasAccess="false"> <div class="col-aside__section"> <h2 id="table-of-content" class="section__heading"> Table of Contents </h2> <div class="section__table-of-contents"> <ul class="table-of-contents__section-list section-list--first-level"> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="At a glance"> At a glance </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Development Overview"> Development Overview </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Introduction"> Introduction </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Company agreements"> Company agreements </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Key development milestones"> Key development milestones </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Patent information"> Patent information </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Drug Properties & Chemical Synopsis"> Drug Properties & Chemical Synopsis </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Biomarker"> Biomarker </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Trial Landscape"> Trial Landscape </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Development Status"> Development Status </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Summary Table"> Summary Table </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Commercial Information"> Commercial Information </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item section-item--first-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Involved Organisations"> Involved Organisations </a> </li> <li class="table-of-contents__section-item section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Credit Suisse Market Status"> Credit Suisse Market Status </a> </li> <li class="table-of-contents__section-item section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Credit Suisse Financial Forecast"> Credit Suisse Financial Forecast </a> </li> </ul> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Scientific Summary"> Scientific Summary </a> <ul class="table-of-contents__section-list section-list--second-level"> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Adverse events"> Adverse events </a> </li> <li class="table-of-contents__section-item"> <a class="table-of-contents__link" href="#disabled" data-track="toc_profiles" data-track-context="drug-profiles" data-track-value="Pharmacodynamics"> 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