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class="col-sm-12"> <h1>About RCSB PDB: A Living Digital Data Resource That Enables Scientific Breakthroughs Across The Biological Sciences</h1><br> <p><a href="#one">Overview</a> | <a href="#two">Services</a> | <a href="#three">Funding</a> | <a href="#four">Users</a> | <a href="#five">Impact</a> | <a href="#six">Collaborations</a> </p> <a class="anchor" id="one"></a> <h3>Overview</h3> <div class="col-md-11 col-md-offset-1"> <a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/rcsb-pdb.png"><img src="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/rcsb-pdb.png" class="col-xs-12 col-sm-6 col-md-6 pull-right"></a> <p>RCSB PDB (RCSB.org) is the US data center for the global Protein Data Bank (PDB) archive of 3D structure data for large biological molecules (proteins, DNA, and RNA) essential for research and education in fundamental biology, health, energy, and biotechnology.</p> <p>The Protein Data Bank (PDB) was established as the 1<sup>st</sup> open access digital data resource in all of biology and medicine (<a href="/pages/about-us/history">Historical Timeline</a>). It is today a leading global resource for experimental data central to scientific discovery.</p> <p>Through an internet information portal and downloadable data archive, PDB provides access to 3D structure data for the molecules of life, found in all organisms on the planet. </p> <p>Knowing the 3D structure of a biological macromolecule is essential for understanding its role in human and animal health and disease, its function in plants and food and energy production, and its importance to other topics related to global prosperity and sustainability.</p> <p>The enormous wealth of 3D structure data stored in the PDB has underpinned significant advances in our understanding of protein architecture, culminating in recent breakthroughs in protein structure prediction accelerated by artificial intelligence approaches and deep or machine learning methods.</p> <p>RCSB PDB (Research Collaboratory for Structural Bioinformatics PDB) operates the US data center for the global PDB archive, and makes PDB data available at no charge to all data consumers without limitations on usage (<a href="/pages/policies">Policies</a>).</p> <p>The Vision of the RCSB PDB is <a href="/pages/about-us/mission"><em data-renderer-mark="true">to expand the frontiers of fundamental biology, biomedicine, energy sciences, and biotechnology through open and sustainable access to 3D biostructure information stored in the Protein Data Bank (PDB) archive and generated using artificial intelligence/machine complemented with functional and evolutionary insights from trusted external resources.</em></a></p> <p>Recognized experts in fields, including but not limited to, structural biology, cell and molecular biology, computational biology, information technology, and education <a href="/pages/advisory-committee">serve as advisors to the RCSB PDB</a>. </p> <div class="col-lg-12 col-sm-12"> <div class="row"> <div class="flex-container"> <div class="flex-item green-wide"> <h4 class="white">PDB Archive contains >1 TB of Structure Data for Proteins, DNA, and RNA</h4> </div> <div class="flex-item red" style="width: 33.3%;"><h4 class="white">The cost to replicate the contents of the PDB archive is estimated at <br><span class="text-large">More than 20 billion</span> <a href="/pages/about-us/economic-impact" class="white underline">(Analysis)</a></h4> </div> </div> </div> <div class="row"> <div class="flex-container"> <div class="flex-item boxes" style="background-color: #f6fef2; width:33.3%;"><h4>The PDB Archive</h4> <ul class="impact"> <li><a href="/stats">Grows at the rate of nearly 10% per year</a></li> <li>Used to download ~5 million structure data files per day</li> <li>Managed by International collaboration US-Asia-Europe </li> <li>Manages “Big Data” as global Public Good </li> <li>Provides data critical to AI/ML development</li> </ul> </div> <div class="flex-item boxes" style="background-color: #eeeded; width:33.3%"><h4>PDB Data</h4> <ul class="impact"> <li><a href="/pages/about-us/bibliometric">Enable research in subject areas from Agriculture to Zoology (Analysis)</a></li> <li><a href="/pages/about-us/bibliometric">Contributed data to nearly >1 million published research papers</a></li> <li>Used by >490 biological data resources</li> </uL> </div> <div class="flex-item boxes" style="background-color:#e8f4fe; width:33.3%"><h4>PDB Data Impact</h4> <ul class="impact"> <li>Basic and applied research</li> <li>Patent applications </li> <li>Discovery of lifesaving drugs</li> <li>Innovations that can lead to new product development and company formation </li> <li>Training, Outreach, and Education: <a href="https://pdb101.rcsb.org">PDB-101</a> materials illustrate how PDB data help explain fundamental biology, biomedicine, energy sciences, and biotechnology</li> </ul> </div> </div> </div> <div class="row"> <div class="flex-container"> <div class="flex-item blue-wide" style="width: 66.6%"><h4 class="white"><span class="text-large">Millions </span> of Data Consumers worldwide served every year </h4> <div class="row"> <div class="col-xs-7"> <p class="white">Researchers, scientists, educators, students, curious public, medical professionals, patients, and patient advocates</p> </div> <div class="col-xs-5"> <p class="white">Public and Private sectors, including pharmaceutical and biotechnology companies</p> </div> </div> </div> <div class="flex-item red" style="width: 33%;"> <h4 class="white">Generates annual <span class="text-large">Return on Investment</span> of more than 1,500 times federal funding <a href="/pages/about-us/economic-impact" class="white underline">(Analysis)</a></h4> </div> </div> </div> </div>  <br> <p> <a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/rcsb-pdb-impact.pdf">Download Printable PDF</a></p> </div> <br>  <h3>Services Supporting Access to the Biological Molecules of the PDB Archive</h3><a class="anchor" id="two"></a> <div class="col-md-11 col-md-offset-1"> <a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/services.png"><img src="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/services.png" class="col-xs-12 col-sm-6 col-md-6 pull-right"></a> <p> <ul> <li><strong>Service 1 Deposition/Biocuration:</strong> supports Data Depositors who submit the results of their structural studies of biological macromolecules to the PDB. All data deposited undergo expert review. Each structure is examined for self-consistency, standardized using controlled vocabularies, cross-referenced with other biological data resources, and validated for scientific/technical accuracy. </li> <li><strong>Service 2 Archive Management and Access: </strong> supports PDB Data Consumers by maintaining the PDB archive; data dictionary development and standardization, enabling global data delivery and DOI registration, and integrating PDB data with other available information.</li> <li><strong>Service 3 Data Exploration: </strong> supports PDB Data Consumers in the US and around the world through our open-access web portal <strong>RCSB.org</strong> that provides tools for structure visualization and analysis.</li> <li><strong>Service 4 Training, Outreach, and Education:</strong> builds and supports the broad PDB user community with a wide range of resources for understanding 3D biostructures.</li> <li><strong>Service 0 IT Infrastructure:</strong> Supports all RCSB PDB Services and systems by establishing policies and processes to ensure standardized systems configurations and management, redundancy, security, high availability, and disaster recovery.</li> </ul> </p> </div> <br><br>  <a class="anchor" id="three"></a> <h3>Funding</h3> <div class="col-md-11 col-md-offset-1"> <p> RCSB PDB is supported by grants from the <a href='http://www.nsf.gov/', target="_blank" rel="noopener" >U.S. National Science Foundation</a> (DBI-2321666), the <a href='http://science.energy.gov/', target="_blank" rel="noopener" >US Department of Energy</a> (DE-SC0019749), and the <a href='http://www.cancer.gov/', target="_blank" rel="noopener" >National Cancer Institute</a>, <a href='http://www.niaid.nih.gov/', target="_blank" rel="noopener" >National Institute of Allergy and Infectious Diseases</a>, and <a href='http://www.nigms.nih.gov/', target="_blank" rel="noopener" > National Institute of General Medical Sciences</a> of the <a href='http://www.nih.gov/', target="_blank" rel="noopener" > National Institutes of Health</a> under grant R01GM157729. </p> <p>In the past, RCSB PDB was also funded by the <a href="https://www.nlm.nih.gov/" target="_blank" rel="noopener" > National Library of Medicine</a>, the National Center for Research Resources, the <a href="https://www.nibib.nih.gov/" target="_blank" rel="noopener" >National Institute of Biomedical Imaging and Bioengineering</a>, and the <a href="https://www.ninds.nih.gov/" target="_blank" rel="noopener" >National Institute of Neurological Disorders and Stroke</a>.</p> <p>Other funding awards to RCSB PDB by the NSF and to PDBe by the UK Biotechnology and Biological Research Council are jointly supporting development of a Next Generation PDB archive (DBI-2019297, PI: S.K. Burley; BB/V004247/1, PI: Sameer Velankar) and new Mol* features (DBI-2129634, PI: S.K. Burley; BB/W017970/1, PI: Sameer. </p> </div> <br><br>  <br> <a class="anchor" id="four"></a> <h3>Users</h3> <div class="col-lg-5 col-sm-5 col-md-offset-1"> <p>RCSB PDB supports an <a href="./pdb-user-community" >international community of users</a>, including biologists (in fields such as structural biology, biochemistry, genetics, pharmacology); other scientists (in fields such as bioinformatics, software developers for data analysis and visualization); students and educators (all levels); media writers, illustrators, textbook authors; and the general public. </p> </div> <div class="col-lg-6 col-sm-6"> <img src="https://cdn.rcsb.org/rcsb-pdb/general_information/news_publications/images/focus/PDB50logo.png"alt="PDB50 logo" class="img-responsive pull-right" ><figcaption><a href="./pdb-user-community" class="pull-right" >Learn more about 50 Years of Community Building and PDB Users</a></figcaption> </div>  <a class="anchor" id="five"></a> <h3>Impact</h3> <div class="col-md-11 col-md-offset-1"> <a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/3-flyers.png"><img src="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/3-flyers.png" class="col-xs-12 col-sm-5 col-md-5 pull-right"></a> <p>RCSB PDB services have broad impact across research and education. The inaugural RCSB PDB citation (Berman <em>et al.,</em> <em>Nucleic Acids Research</em> 2000) is one of the top-cited scientific publications of all time. A <a href="/pages/about-us/bibliometric">2017 bibliometric analysis </a>performed by Clarivate Analytics shows PDB motivated high-quality research throughout the world. Papers citing had a citation-based impact exceeding the world-average in 16 scientific fields including Biology & Biochemistry, Computer Science, Plant & Animal Sciences, Physics, Environment/Ecology, Mathematics and Geosciences.</p> <p>A 2017 <a href="/pages/about-us/economic-impact">economic analysis </a>performed by the Rutgers Office of Research Analytics noted that a reasonable estimate to replicate the PDB data archive at the time was $12 billion. </p> <uL> <li>Impact of PDB Structures on US FDA Drug Approvals 2010-2016 (<a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/PDB-impact-drug_approvals2010-2016.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>Supporting the Opportunities and Grand Challenges of the NSF (<a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/nsf-2024.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>Supporting the NIH <em>Turn Discovery into Health</em> (<a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/nih-2024.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>Supporting the Research Goals of DOE (<a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/doe-2024.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>Impact of PDB Structures on Anti-Cancer Drug Approvals (<a href="https://cdn.rcsb.org/rcsb-pdb/v2/about-us/cancer-drugs-pdb-impact.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>PDB Structures and the Pandemic (<a href="https://cdn.rcsb.org/rcsb-pdb/v2/about-us/covid-pdb-data-2023.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li>Protein Data Bank and 50 years of Molecular Structures (<a href="https://cdn.rcsb.org/rcsb-pdb/v2/about-us/PDB-50-pitch.pdf" target="_blank" rel="noopener" >PDF</a>)</li> <li><a href="https://cdn.rcsb.org/rcsb-pdb/pdb50mesh/index.html" target="_blank" rel="noopener" >PDB Citation MeSH Network Explorer </a></li> </uL> <br> </div>  <a class="anchor" id="six"></a> <h3>Collaborations</h3> <div class="col-md-11 col-md-offset-1"> <a href="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/wwpdb.png"><img src="http://cdn.rcsb.org/rcsb-pdb/v2/about-us/wwpdb.png" class="col-xs-12 col-sm-7 col-md-7 pull-right"></a> <h4>Worldwide Protein Data Bank (wwPDB)</h4> <p>The Worldwide Protein Data Bank (<a href="http://wwpdb.org/">wwPDB</a>) was formed to maintain a single PDB archive of macromolecular structural data that is freely and publicly available to the global community. It consists of organizations that act as deposition, data processing and distribution centers for PDB data. As the US Data Center, RCSB PDB biocurates structures submitted from the Americas and Oceania.<br></p> <h4>PDB-Dev</h4> <p><a href="https://pdb-dev.wwpdb.org/index.html">PDB-Dev</a> is a prototype archiving system for structural models obtained using integrative or hybrid modeling.</p> <h4>EMDataResource</h4> <p><a href="https://www.emdataresource.org">EMDataResource</a> provides access to 3DEM density maps and metadata, news, events, software tools, data standards, and validation methods. <br></p> <h4>KBase</h4> <p><a href="https://www.kbase.us/">KBase</a> enables users to analyze, share, and collaborate using data and tools designed to help build increasingly realistic models for biological function. KBase utilizes RCSB PDB APIs to provide users with access to PDB data.</p> <h4>Nucleic Acid Knowledgebase</h4> <a href="https://nakb.org" target="_blank">NAKB</a> contains information about experimentally-determined nucleic acids and complex assemblies. </div> </div>  </div> </div> </div></div><div data-elastic-exclude><div class="hidden-print" id="footer_main"><div class="container" style="padding:0"><div class="row"><div class="col-md-6 col-sm-12" style="padding-left:0"> <div class="row"><div class="col-sm-4"><ul><li><span class="row_header">About</span></li><li><a href="/pages/about-us/index">About Us</a></li><li><a href="/pages/policies#References">Citing Us</a></li><li><a href="/pages/publications">Publications</a></li><li><a href="/pages/team">Team</a></li><li><a href="/pages/jobs">Careers</a></li><li><a href="/pages/policies">Usage & Privacy</a></li></ul></div><div class="col-sm-4" style="padding-left:0"><ul><li><span class="row_header">Support</span></li><li><a href="/pages/contactus">Contact Us</a></li><li><a href="/help">Help</a></li><li><a href="/docs/general-help/website-faq">Website FAQ</a></li><li><a href="/docs/general-help/glossary">Glossary</a></li><li><a href="https://status.rcsb.org/" target="_blank">Service Status</a></li></ul></div><div class="col-md-4 hidden-sm"></div></div></div><div class="col-md-6 col-sm-12" style="padding-left:5px"> <div class="row"><div class="col-sm-4"><p class="row_header">RCSB PDB is hosted by</p><div class="footerLogos"><hr><a href="http://www.rutgers.edu/"><img class="Rutgerslogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_Rutgers-2024.png" alt="Rutgers University logo"></a><hr><a href="https://ucsd.edu/"><img class="UCSDlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSD-navy.png" alt="Uiversity of California San Diego logo"></a><a href="https://www.sdsc.edu/"><img class="SDSClogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_SDSC-black.png" alt="San Diego Supercomputer Center logo"></a><hr><a href="https://www.ucsf.edu/"><img class="UCSFlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSF.png" alt="University of California San Francisco Logo"></a></div></div><div class="col-sm-4"><p class="row_header">RCSB PDB is a member of the</p><div class="footerLogos"><span id="pdbmembers_footer"><hr><a href="https://www.wwpdb.org" target="_blank" rel="noopener"><img class="wwpdblogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_wwpdb.png" alt="wwPDB"></a><hr><a href="https://www.emdataresource.org" target="_blank" rel="noopener"><img id="emdatabanklogo_footer" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/EMDataResourcelogo.png" alt="EMDataResource"></a></span></div></div><div class="col-sm-4"><ul><li><span class="row_header">RCSB Partners</span></li><li><a href="https://nakb.org/" target="_blank" rel="noopener">Nucleic Acid Knowledgebase</a></li></ul><ul><li><span class="row_header"><a href="https://www.wwpdb.org/" target="_blank" rel="noopener" style="text-decoration: none; color: black">wwPDB Partners</a></span></li><li><a href="/">RCSB PDB</a></li><li><a href="https://www.ebi.ac.uk/pdbe/" target="_blank" rel="noopener">PDBe</a></li><li><a href="https://www.pdbj.org/" target="_blank" rel="noopener">PDBj</a></li><li><a href="https://bmrb.io/" target="_blank" rel="noopener">BMRB</a></li><li><a href="https://emdb-empiar.org/" target="_blank" rel="noopener">EMDB</a></li></ul></div></div></div></div></div></div><div id="footer_grant"><div class="container"><div class="row"><p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank" rel="noopener">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank" rel="noopener">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank" rel="noopener">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank" rel="noopener">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank" rel="noopener">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank" rel="noopener">National Institutes of Health</a> under grant R01GM157729.</p></div></div></div><div id="jira-fdbck"></div></div></div></body></html>