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.content-5050-large h3 { font-size: 28px; line-height: 36px; } /* lighten parent page label in hero */ body.page-template-product-child-page .site-hero .badge, body.page-template-product-database-page .site-hero .badge { background: rgba(106, 110, 245, 0.25); } /* prevent svg icon blending with active background */ body .vertical.tabs .tabs-title.is-active img.icon { background: #fff; border-radius: 50%; box-shadow: 0 0 0 2px #0068a6; } body.is-mobile .hero__background-video { display: none !important; } body.is-mobile.home .hero.hero--advanced:before { background: linear-gradient(332deg, #001d2e 10.11%, #00314e 93.63%); } /* Remove bottom padding on pages w/ multi-line supported logos */ .supported-logos-multi-row { padding-top: 40px; padding-bottom: 0px; } /*Remove load More on Symposium*/ .agenda-block { height: auto !important; } .agenda-block .symposium-agenda-loadmore { display: none !important; } /* Slider dots sit below images on product pages */ @media screen and (min-width: 1200px) { .views-slider-container .slick-dots { bottom: auto; } } /*Style drop-down fields like text boxes */ .gfield_select { background-color: #ffffff; border: 1px solid #8baed4; } /* Remove padding from cards for Resource pages */ @media print, screen and (min-width: 64em) { .flexible-page-cards-no-padding { padding: 30px 0; } } .flexible-page-cards-no-padding { padding: 30px 0; } .flexible-page-cards-no-padding .card-row { display: flex; align-items: center; justify-content: center; } .flexible-page-cards-no-padding .card-row .main-link { display: inline-block; max-width: 441px; } .flexible-page-cards-no-padding a { text-decoration: none; font-weight: initial; } @media print, screen and (min-width: 40em) { .flexible-page-cards-no-padding .card { height: 100%; margin-left: 12px; margin-right: 12px; } } @media screen and (max-width: 39.99875em) { .flexible-page-cards-no-padding .card-row { flex-wrap: wrap; } .flexible-page-cards-no-padding .card { width: 100%; height: auto; margin-bottom: 16px; } } .flexible-page-cards-no-padding .card { background: #fff; margin-bottom: 22px; padding: 40px 30px; border: solid 1px #6a6ef4; display: flex; flex-direction: column; align-items: flex-start; justify-content: center; box-shadow: 0px 10px 24px rgb(106 110 244 / 15%); } .flexible-page-cards-no-padding h4 { color: #0067a6; } .flexible-page-cards-no-padding .card p { font-size: 16px; line-height: 25px; letter-spacing: 0.5px; color: #767676; } /* Supported Logos Multi-Row (use this for all except the bottom row)*/ .page-template-product-child-page .supported-logos-multi-row, .page-template-product-database-page .supported-logos-multi-row { padding-top: 40px; padding-bottom: 0px; } .page-template-product-child-page .supported-logos-multi-row .logos, .page-template-product-database-page .supported-logos-multi-row .logos { list-style: none; max-width: 1000px; margin-left: auto; margin-right: auto; display: flex; align-items: center; justify-content: center; flex-wrap: wrap; } .page-template-product-child-page .supported-logos-multi-row .logos li, .page-template-product-database-page .supported-logos-multi-row .logos li { width: 100px; margin: 15px; } .page-template-product-child-page .supported-logos-multi-row .link-container, .page-template-product-database-page .supported-logos-multi-row .link-container { margin-top: 20px; } .page-template-product-child-page .supported-logos-multi-row .link-container .arrow-link, .page-template-product-database-page .supported-logos-multi-row .link-container .arrow-link { display: block; text-decoration: none; } /* White text, specifically checkbox label on dark background */ .page-template-product-child-page .pricing-block #gform_wrapper_62 .gfield_checkbox label { color: #fff; } /*Bulleted List with X bullets (Blog) */ ul.fancy-list-x { max-width: 100%; list-style: none; margin-left: 0; margin-bottom: 0; } ul.fancy-list-x li { padding-left: 1.5625rem !important; margin-bottom: 22px; position: relative !important; font-size: 16px; line-height: 25px; letter-spacing: 0.5px; font-family: 'Proxima Nova', 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; max-width: 100%; } ul.fancy-list-x li .svg-inline--fa { content: '' !important; display: inline-block !important; } ul.fancy-list-x li::before, ul.fancy-list-x li .svg-inline--fa { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; content: '\f057' !important; width: auto !important; height: 1rem !important; display: none; font-size: 0.7rem !important; font-family: 'Font Awesome 5 Solid' !important; color: #ff0000 !important; } ul.fancy-list-x li .svg-inline--fa path { color: #ff0000 !important; } /* NEW SIDE MENU MISSING CODE FROM BUILD override*/ .new-side-menu { position: fixed; right: 0; top: 12.5rem; background: rgba(245, 245, 245, 0.9); box-shadow: 0px 4px 20px rgba(0, 0, 0, 0.1); backdrop-filter: blur(30px); border-radius: 0.5rem 0 0 0.5rem; padding: 1.875rem 1.25rem; width: 14.6875rem; display: none; } @media screen and (min-width: 101.25em) { .new-side-menu.show { display: block; } } .new-side-menu ul { list-style: none; margin-left: 0; margin-bottom: 0; text-align: right; } .new-side-menu ul li { margin: 0; } .new-side-menu ul li ~ li { margin-top: 0.8125rem; } .new-side-menu ul li a { font-family: 'Proxima Nova', 'Helvetica Neue', Helvetica, Roboto, Arial, sans-serif; font-style: normal; font-weight: 400; font-size: 14px; line-height: 24px; letter-spacing: 0.5px; text-decoration: none; color: #001d2e; position: relative; display: flex; align-items: center; justify-content: flex-end; } .notification-bar { position: static; background: #6a6ef4; } .notification-bar a, .notification-bar a:hover, .notification-bar p { color: #ffffff; } .new-side-menu ul li a:hover { color: #00b471; } .new-side-menu ul li a:after { content: ''; display: block; width: 0.4375rem; height: 0.4375rem; background: transparent; border: 0.0625rem solid #767676; border-radius: 50%; margin-left: 0.625rem; } .new-side-menu ul li a.active { color: #00b471; } .new-side-menu ul li a.active:after { background: #00b471; border-color: #00b471; } /*Tech Support Right-side Boxes*/ .flexible-tech-support { padding: 60px 0; } @media print, screen and (min-width: 64em) { .flexible-tech-support { padding: 100px 0; } } @media print, screen and (min-width: 64em) { .flexible-tech-support h2 { margin-bottom: 40px; } } .flexible-tech-support h4 { color: #0067a6; } .flexible-tech-support a { text-decoration: none; font-weight: initial; } .flexible-tech-support .card { background: #fff; margin-bottom: 22px; padding: 40px 30px; border: solid 1px #6a6ef4; display: flex; flex-direction: column; align-items: flex-start; justify-content: center; box-shadow: 0px 10px 24px rgba(106, 110, 244, 0.15); } .flexible-tech-support .card.dark { background: linear-gradient(84.29deg, #001d2e 1.61%, #00314e 74.62%); } .flexible-tech-support .card.dark h4, .flexible-tech-support .card.dark p, .flexible-tech-support .card.dark a { color: #fff !important; } @media screen and (max-width: 39.99875em) { .flexible-tech-support .card h4 { font-size: 25px; } } @media print, screen and (min-width: 40em) { .flexible-tech-support .card { height: 100%; margin-left: 12px; margin-right: 12px; } } .flexible-tech-support .card p { font-size: 16px; line-height: 25px; letter-spacing: 0.5px; color: #767676; } .flexible-tech-support .card .arrow-link { font-weight: bold; } .js-error-log p { background: #fff9f9; border: 1px solid #c02b0a; font-size: 14.992px; margin-top: 8px; color: #c02b0a !important; padding: 12.992px 24px; clear: both; font-family: inherit; font-size: 15px; letter-spacing: normal; line-height: inherit; padding-top: 13px; width: 100%; font-weight: bold !important; } .resource-tab__item { position: relative; padding-top: rem-calc(40) !important; } .item-absolute { font-weight: bold; position: absolute; padding: 10px 20px; top: 0; right: 0; background: #001d2e; color: #a6a9ff; pointer-events: none; margin: 0; } /*Add padding to display "data-type" labels on portal resource boxes*/ @media print, screen and (min-width: 64em) { .portal-resource-list .resource-tab__item { padding: 40px 40px 20px 40px; /*color: blue;*/ } } ul.fancy-list li::before, ul.fancy-list li .svg-inline--fa { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; } ul.fancy-list li::before, ul.fancy-list li svg { position: absolute; top: 4px; right: auto; bottom: auto; left: 0; } .portal-resource-list .resource-tab__item { padding: 40px 40px; padding-top: 50px; } #gform_wrapper_71 { max-width: 636px; margin: auto; padding: 30px 20px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); } @media print, screen and (min-width: 40em) { #gform_wrapper_71 { padding: 50px 74px; } } #gform_wrapper_71 h2 { max-width: 700px; margin: auto; text-align: center; color: #0067a6; } #gform_wrapper_71 h5 { color: #6a6ef4; } #gform_wrapper_71 .ginput_complex { display: block; } #gform_wrapper_71 .ginput_complex span { display: block; padding: 0px; margin: 0px; } #gform_wrapper_71 .ginput_complex span:first-child { margin-bottom: 16px; } #gform_wrapper_71 .form-position { display: flex; flex-wrap: wrap; justify-content: center; align-items: center; background: #f1f5fa; padding: 13px; margin: 22px 0; } @media print, screen and (min-width: 64em) { #gform_wrapper_71 .form-position { margin: 42px 0; margin-bottom: 62px; } } #gform_wrapper_71 .form-position p { margin-bottom: 0px; font-size: 14px; line-height: 18px; letter-spacing: 0.8px; color: #0067a6; font-weight: bold; max-width: 90px; } #gform_wrapper_71 .form-position p.active { color: #6a6ef4; } #gform_wrapper_71 .form-position span { background: #0067a6; color: #fff; width: 30px; height: 30px; display: flex; align-items: center; justify-content: center; border-radius: 50%; margin: 0 22px; } #gform_wrapper_71 .gfield_label { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 input[type='text'], #gform_wrapper_71 input[type='email'], #gform_wrapper_71 textarea { background: #ffffff; border: 1px solid #8baed4; } #gform_wrapper_71 input[type='text']::placeholder, #gform_wrapper_71 input[type='email']::placeholder, #gform_wrapper_71 textarea::placeholder { color: #767676; } #gform_wrapper_71 #input_13_8 { border: none; padding: 0px !important; } #gform_wrapper_71 select { padding-right: 33px !important; color: #767676; } #gform_wrapper_71 select::placeholder { color: #767676; } #gform_wrapper_71 #field_6_8 label { font-size: 16px; line-height: 19px; letter-spacing: 3px; text-transform: uppercase; color: #6a6ef4; } #gform_wrapper_71 #field_6_8 .gfield_description { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 #field_6_8 #file-upload-button { border: 1px solid #001d2e; box-sizing: border-box; box-shadow: 0px 16px 24px rgba(106, 110, 244, 0.184583); border-radius: 2px; padding: 24px; background: #fff; } #gform_wrapper_71 fieldset .gfield_label { font-size: 16px; line-height: 24px; color: #0067a6; font-weight: bold; } #gform_wrapper_71 #gform_submit_button_6, #gform_wrapper_71 .gform_next_button { width: 100%; } #gform_wrapper_71 .gform_previous_button, #gform_wrapper_71 .gform_fileupload_rules { display: none; } #gform_wrapper_71 #gfield_instruction_13_29 { display: none; } #gform_wrapper_71 #input_13_28 { display: flex; margin-bottom: 0px; } #gform_wrapper_71 #field_13_29 .gfield_description, #gform_wrapper_71 #field_13_30 .gfield_description, #gform_wrapper_71 #field_13_26 .gfield_description { display: block; font-size: 14px; color: #767676; background: #fff; padding: 4px 10px; margin-top: 10px; } #gform_wrapper_71 #field_13_29 .gform_page_footer input + input, #gform_wrapper_71 #field_13_30 .gform_page_footer input + input, #gform_wrapper_71 #field_13_26 .gform_page_footer input + input { margin-left: 0px; } /* Blog Author */ .content-area section.nv-author { padding-bottom: 80px !important; } .nv-author { background-color: #f1f2f2; margin-top: 30px; padding-top: 30px; padding-left: 30px; padding-right: 30px; } .nv-author__image { float: left; margin-right: 20px; } .single-post h4.nv-author__name { margin-bottom: 5px; color: #6a6ef4; } .nv-author__description { clear: both; padding-top: 10px; font-size: 0.9rem; } /* Segmentations */ .page-id-13757 .grid-container #gform_wrapper_81 { display: flex; align-items: center; justify-content: center; } .page-id-13757 #gform_wrapper_81 .gchoice label { color: #767676; line-height: 24px; letter-spacing: 1.125px; } /* Nurture Footer Form */ /* Academia */ .subscribe-cta .grid-container .gform_wrapper #field_55_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_55_1 .ginput_container { width: 100%; } /* ADMS */ .subscribe-cta .grid-container .gform_wrapper #field_28_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_28_1 .ginput_container { width: 100%; } /* Chemists/Analysts */ .subscribe-cta .grid-container .gform_wrapper #field_65_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_65_1 .ginput_container { width: 100%; } /* Chrom */ .subscribe-cta .grid-container .gform_wrapper #field_42_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_42_1 .ginput_container { width: 100%; } /* Elucidation & Verification */ .subscribe-cta .grid-container .gform_wrapper #field_63_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_63_1 .ginput_container { width: 100%; } /* Impurities */ .subscribe-cta .grid-container .gform_wrapper #field_46_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_46_1 .ginput_container { width: 100%; } /* Luminata PharmDev & Regulatory */ .subscribe-cta .grid-container .gform_wrapper #field_40_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_40_1 .ginput_container { width: 100%; } /* MS */ .subscribe-cta .grid-container .gform_wrapper #field_31_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_31_1 .ginput_container { width: 100%; } /* NMR */ .subscribe-cta .grid-container .gform_wrapper #field_44_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_44_1 .ginput_container { width: 100%; } /* Parallel Chem & HTE */ .subscribe-cta .grid-container .gform_wrapper #field_43_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_43_1 .ginput_container { width: 100%; } /* Percepta/Property Prediction */ .subscribe-cta .grid-container .gform_wrapper #field_78_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_78_1 .ginput_container { width: 100%; } /* Structure Drawing */ .subscribe-cta .grid-container .gform_wrapper #field_45_1 { display: flex; align-items: center; justify-content: flex-end; } .subscribe-cta .grid-container .gform_wrapper #field_45_1 .ginput_container { width: 100%; } .gform_wrapper #field_74_20 .gfield_radio { display: flex; } .gform_wrapper #field_74_20 .gchoice { margin-right: 30px; } .color-js { color: #00adee; } .deployment { position: absolute; padding: 10px 30px; top: 0; left: 0; font-size: 1.5em; font-style: italic; } .page-template-product-child-page .text-editor .main-color-green .js-list ul ::marker{ color: #00adee; !important } /*Portal Difficulty*/ .portal-resource-list .resource-tab__item .item-difficulty.qsg { background: #EDFCF5; color: #2C664A; } .portal-resource-list .resource-tab__item .item-difficulty.training { background: #FCF7ED; color: #735132; } .portal-resource-list .resource-tab__item .item-difficulty { top: 20px; } /*Spectrus JS Page*/ @media print, screen and (min-width: 40em) .site-hero .cell, .page-id-1389 .site-hero .cell { max-width: 680px; text-align: left; margin-top: 32px; } .page-id-1389 .site-hero .cell { max-width: 680px; text-align: left; margin-top: 32px; } .page-id-1389 .site-hero__title { color: #00FFA0; font-size: 24px; line-height: 29px; letter-spacing: 3px; text-align: left; } .page-id-1389 .supported-logos { padding-top: 40px; padding-bottom: 80px; } .page-id-1389 .supported-logos .logos { list-style: none; max-width: 1000px; margin-left: auto; margin-right: auto; display: flex; align-items: center; justify-content: center; flex-wrap: wrap; } .page-id-1389 .supported-logos .logos li { width: 100px; margin: 15px; } .page-id-1389 .supported-logos .link-container { margin-top: 20px; } .page-id-1389 .supported-logos .link-container .arrow-link { display: block; text-decoration: none; }.page-id-1389 .fancy-list li::before, .page-id-1389 .fancy-list li .svg-inline--fa, .page-id-1389 .fancy-list li .svg-inline--fa path{ color: #00B471 !important; } .page-id-1389 .icon-item-row .icon-item img{ height: 60px; width: auto; margin-bottom: 15px; } .page-id-1389 .icon-item-row .icon-item { margin: 15px; display: flex; flex-direction: column; align-items: center; } /*Products Mega Menu*/ .flyout.submenu-1, .site-header.is-opaque .site-bar .site-navigation .sub-menu.submenu-1, .site-header .site-bar .site-navigation .sub-menu.submenu-1 { background-color: #fff; background-image: none; } /*Spectrus Processor*/ .pricing-block .button.green, .comments-area .comment-form .form-submit input[type="submit"], .button--inline-form, .hero--advanced .hero__transform-container .hero__button { background: linear-gradient(to right, #00B471, #00FFA0); border-radius: 2px; font-weight: 800; box-shadow: 0px 16px 24px rgba(106, 110, 244, 0.243098); border: none; line-height: 24px; letter-spacing: 0.8px; text-decoration: none; color: #0a0a0a; } .pricing-block .button.white { background: transparent !important; box-shadow: none; border: solid 1px #fff; color: #fff !important; } .color-lt-green{ color:#00ffa0; } .disclaimer { font-size: .85em; } /*Form Labels */ [type='checkbox'] + label, [type='radio'] + label { display: inline; } /*ChemSketch Freeware*/ .page-id-3441 .demo-cta { position: relative; } .page-id-3441 .demo-cta .background { position: absolute; top: 0; left: 0; width: 100%; height: 100%; background-size: cover; background-position: center; z-index: 0; } .page-id-3441 .demo-cta #gform_wrapper_8 { background: #0a0a0a; position: relative; z-index: 1; margin-top: -50px; margin-bottom: -50px; padding: 40px 20px; } @media print, screen and (min-width: 40em) .page-id-3441 .demo-cta #gform_wrapper_8 { padding: 70px 60px; padding-bottom: 30px; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_html { text-align: center; color: #fff; } .page-id-3441 .demo-cta.form-color-purple h3 { color: #A6A9FF; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_html h3{ margin-bottom: 12px; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_checkbox { margin-bottom: 0px !important; } .page-id-3441 .demo-cta #gform_wrapper_8 .gfield_checkbox label { color: #fff; display: inline; } .page-id-3441 .demo-cta #gform_wrapper_8 .button { margin-top: 22px; display: block; width: 100%; } .page-id-3441 .demo-cta #gform_confirmation_wrapper_8 { background: #0a0a0a; position: relative; z-index: 1; margin-top: -50px; margin-bottom: -50px; padding: 40px 20px; } .page-id-3441 .demo-cta #gform_confirmation_wrapper_8 .gform_confirmation_message { background: none; border: none; } /*Flexible Layouts */ /* Icon Item Row */ .page-template-default .icon-item-row .icon-item { margin: 15px; display: flex; flex-direction: column; align-items: center; } /*Sidebar Content Bullets */ .page-template-default .flexible-sidebar-content .flexible-sidebar ul.fancy-list li .svg-inline--fa path { color: #fff !important; } .page-template-default blockquote { font-size: inherit; padding-left: 30px; padding-right: 30px; } /* Steps Block */ .page-template-default .steps-block .content { padding: 60px 20px; color: #fff; background-size: cover; background-position: center; } @media print, screen and (min-width: 40em) .page-template-default .steps-block .content .content-container { max-width: 22rem; margin-left: auto; margin-right: 2rem; } .page-template-default .steps-block .content .content-container { max-width: 22rem; margin-left: auto; margin-right: 2rem; } @media print, screen and (min-width: 40em) .page-template-default .steps-block .steps .content-container { max-width: 37rem; margin-left: 2rem; margin-right: auto; } .page-template-default .steps-block .steps .content-container { max-width: 37rem; margin-left: 2rem; margin-right: auto; } .page-template-default .steps-block .content-container { height: 100%; display: flex; flex-direction: column; justify-content: center; } .page-template-default .steps-block .steps { padding: 60px 20px; } .page-template-default .steps-block .steps ul { list-style: none; } .page-template-default .steps-block .steps li { position: relative; border-left: solid 1px #6A6EF4; padding-left: 40px; padding-bottom: 40px; padding-top: 10px; color: #fff; margin-bottom: 0px; } .page-template-default .steps-block .steps li .count { position: absolute; width: 40px; height: 40px; border-radius: 50%; background: #6A6EF4; color: #fff; display: flex; align-items: center; justify-content: center; font-weight: bold; left: -20px; top: 0px; } .page-template-default .steps-block .steps li:last-child { padding-bottom: 0px; } .page-template-default .icon-item-row .icon-item img { height: 70px; width: auto; margin-bottom: 15px; } /*Spectrus Processor JS */ #gform_wrapper_35 .gform_footer input[type=submit] { background: linear-gradient(to right, #FFFFFF, #8BAED4); color:#011d2e; } .page-id-13941 .simple-cta .link-container { justify-content: flex-start; } #gform_confirmation_wrapper_35 .gform_confirmation_message { border: none; background: #777bf5; color:#FFFFFF; } @media print, screen and (min-width: 64em) .single-portal-resource .main-content { padding-right: 30px; } .single-portal-resource .main-content { padding-right: 30px; } /* Blog Edits for Mobile */ @media only screen and (max-width: 600px) { /* Display email field as 100% width */ .post-template-default .gform_wrapper.gravity-theme .gfield.gfield--width-half { grid-column: span 12; } /* Hide form on top of Related Posts */ .blog-subscribe-cta { display:none; } /* Display images full width */ .post-template-default img { width:100%; } } /* Blog Edits for all sign-up forms */ .post-template-default .nv-blog-post .grid-container { padding: 0px; } .blog-subscribe-cta{ margin-bottom: 30px; } /*Blog Sign-up Form - ADMS */ .post-template-default .nv-blog-post #gform_28 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_28 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_28{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_28_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_28 #field_28_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_28 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_28 h4{ color: #FFFFFF; } #gform_wrapper_28 .gform_footer { margin-top: 0px; } #gform_wrapper_28 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar ADMS */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_28 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_28 #field_28_1 #field_28_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_28 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_28_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - ChemSketch */ .post-template-default .nv-blog-post #gform_45 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_45 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_45{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_45_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_45 #field_45_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_45 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_45 h4{ color: #FFFFFF; } #gform_wrapper_45 .gform_footer { margin-top: 0px; } #gform_wrapper_45 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar ChemSketch */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_45 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_45 #field_45_1 #field_45_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_45 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_45_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Chrom*/ .post-template-default .nv-blog-post #gform_42 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_42 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_42{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_42_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_42 #field_42_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_42 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_42 h4{ color: #FFFFFF; } #gform_wrapper_42 .gform_footer { margin-top: 0px; } #gform_wrapper_42 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Chrom*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_42 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_42 #field_42_1 #field_42_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_42 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_42_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Katalyst*/ .post-template-default .nv-blog-post #gform_43 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_43 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_43{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_43_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_43 #field_43_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_43 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_43 h4{ color: #FFFFFF; } #gform_wrapper_43 .gform_footer { margin-top: 0px; } #gform_wrapper_43 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Katalyst*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_43 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_43 #field_43_1 #field_43_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_43 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_43_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Luminata*/ .post-template-default .nv-blog-post #gform_40 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_40 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_40{ width:100%; } .post-template-default .grid-container .gform_wrapper #field_40_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_40 #field_40_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_40 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_40 h4{ color: #FFFFFF; } #gform_wrapper_40 .gform_footer { margin-top: 0px; } #gform_wrapper_40 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Luminata*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_40 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_40 #field_40_1 #field_40_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_40 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_40_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - MS */ .post-template-default .nv-blog-post #gform_31 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_31 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_31 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_31_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_31 #field_31_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_31 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_31 h4{ color: #FFFFFF; } #gform_wrapper_31 .gform_footer { margin-top: 0px; } #gform_wrapper_31 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar MS */ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_31 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_31 #field_31_1 #field_31_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_31 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_31_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - NMR*/ .post-template-default .nv-blog-post #gform_44 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_44 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_44 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_44_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_44 #field_44_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_44 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_44 h4{ color: #FFFFFF; } #gform_wrapper_44 .gform_footer { margin-top: 0px; } #gform_wrapper_44 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar NMR*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_44 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_44 #field_44_1 #field_44_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_44 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_44_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Percepta*/ .post-template-default .nv-blog-post #gform_78 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_78 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_78 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_78_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_78 #field_78_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_78 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_78 h4{ color: #FFFFFF; } #gform_wrapper_78 .gform_footer { margin-top: 0px; } #gform_wrapper_78 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Percepta*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_78 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_78 #field_78_1 #field_78_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_78 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_78_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Verification*/ .post-template-default .nv-blog-post #gform_63 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_63 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_63 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_63_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_63 #field_63_1{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_63 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_63 h4{ color: #FFFFFF; } #gform_wrapper_63 .gform_footer { margin-top: 0px; } #gform_wrapper_63 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Verification*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_63 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_63 #field_63_1 #field_63_4 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_63 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_63_1 .ginput_container { width: 100%; } /*Blog Sign-up Form - Newsletter*/ .post-template-default .nv-blog-post #gform_2 { display: flex; align-items: center; justify-content: flex-end; } @media only screen and (max-width: 600px) { .post-template-default .nv-blog-post #gform_2 { display: block; } .post-template-default .nv-blog-post #gform_wrapper_2 { width:100%; } .post-template-default .grid-container .gform_wrapper #field_2_1 .ginput_container { width:100%; } } .post-template-default .nv-blog-post #gform_wrapper_2 #field_2_2{ display: flex; align-items: center; justify-content: flex-end; } .post-template-default .nv-blog-post #gform_wrapper_2 { background: #011d2e; padding:20px; color: #FFFFFF; margin-bottom: 20px; } .post-template-default .nv-blog-post #gform_wrapper_2 h4{ color: #FFFFFF; } #gform_wrapper_2 .gform_footer { margin-top: 0px; } #gform_wrapper_2 .gform_footer input[type=submit] { border-radius: 0px 2px 2px 0px; margin-bottom: 0px; border: none; font-weight: bold; background: linear-gradient(99.71deg, #8baed4 14.34%, #6a6ef4 94.18%); height: 47px; } /*Blog Sign-up Form - Sidebar Newsletter*/ .post-template-default .nv-blog-post .blog-subscribe-cta #gform_2 { display: block; align-items: center; justify-content: flex-end; } .blog-subscribe-cta .grid-container #gform_wrapper_2 #field_2_2 #field_2_1 { display: flex; align-items: center; justify-content: flex-end; } .blog-subscribe-cta #gform_wrapper_2 .gfield.gfield--width-half { grid-column: span 12; } .blog-subscribe-cta .grid-container .gform_wrapper #field_2_2 .ginput_container { width: 100%; } /*Remove bullet from AutoChrom table */ #autochrom_modal.reveal .slick-slide table td:not(.heading):before { content: ''; position: absolute; top: 0px; left: 0px; } /* Add background color to header row */ #autochrom_modal.reveal .slick-slide table th.heading { color: #FFFFFF !important; font-size: 20px !important; text-align: center !important; background-color: #00B471 !important } /* Add background color to tabs to distinguish them @media screen and (min-width: 768px) .simple-tab .tabs.converted-tab li a.selected { background-color: #00B471; }*/ /* START Marek Logo Updates */ body .site-branding__logo img, body .site-branding__logo svg, body .site-branding__alt-logo img, body .site-branding__alt-logo svg { width: 225px !important; height: auto !important; max-width: 100%; } body .site-header .site-bar .site-navigation .layer-2 ul.main-nav .top-link { padding-right: 8px; } body .site-header .site-bar .site-navigation .layer-2 ul.main-nav .menu-item.has-children .top-link svg { font-size: 11px; margin-left: 0; } body .site-header.transparent.is-opaque .site-branding__alt-logo { display: flex; align-items: center; justify-content: flex-start; } body .site-header.site-header .site-bar .site-navigation .layer-2 ul.main-nav .top-link { font-size: 13px; font-weight: 600; } body .layer-1 a:not(.login):not(.register) { font-weight: 700; } body .site-header a { -webkit-font-smoothing: antialiased; } /* END Marek Logo Updates */ .widecolumn { margin: 0 auto 600px; text-align: center; padding: 100px 15px 0; max-height: 1200px; } .reveal{ transition: 0s; } /* Scroll up for bookmarks on Symposium page */ #day1 { scroll-margin-top: 120px; } #day2 { scroll-margin-top: 120px; } #register { scroll-margin-top: 120px; } #posters { scroll-margin-top: 120px; } #symposium { scroll-margin-top: 120px; } #refer { scroll-margin-top: 200px; } #percepta { scroll-margin-top:500px; } /* flexible Event Agenda */ .page-template-default .symposium-agenda { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .page-template-default .symposium-agenda .agenda-block { padding: 0px 40px; width: 100%; max-width: 996px; margin: auto; margin-top: 30px; background: #fff; border-top: solid 4px #6A6EF4; border-radius: 4px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); overflow: hidden; position: relative; height: auto !important; } .page-template-default .symposium-agenda .agenda-block__item { padding: 25px 0px; border-bottom: 1px solid rgba(118, 118, 118, 0.1); } .page-template-default .symposium-agenda .agenda-block__item .time-frame { color: #6A6EF4; } .page-template-default .symposium-agenda .agenda-block__item .item-title { color: #0067A6; font-size: 16px; line-height: 24px; } .page-template-default .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .page-template-default .speaker .headshot { display: block; width: 65px; height: 65px; border-radius: 50%; overflow: hidden; background: #f1f1f1; background-size: cover; background-position: center; margin-right: 14px; flex: 0 0 67px; } .page-template-default .webinar-single-hosts { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .page-template-default .webinar-single-hosts h5 { margin-bottom: 45px; } .page-template-default .webinar-single-hosts .speaker { align-items: flex-start; } .page-template-default .speaker div { width: 100%; } .page-template-default .event-meta { flex-wrap: wrap; margin-top: 16px; margin-bottom: 20px; display:block; } @media print, screen and (min-width: 64em) .page-template-default .symposium-agenda { padding: 70px 0; padding-bottom: 100px; } .webinar-single-hosts { padding: 70px 0; padding-bottom: 100px; } #gform_wrapper_74 .gfield_label { color: #FFFFFF; } /* Blog Heading 5 */ .single-post .single-entry__content h5 { color: #0067A6; font-style: italic; } /* Discount Code Coupon Box */ .woocommerce #content table.cart td.actions .input-text, .woocommerce table.cart td.actions .input-text, .woocommerce-page #content table.cart td.actions .input-text, .woocommerce-page table.cart td.actions .input-text { width:150px; } .disclaimer #content p { padding: 20px 0; } /* Registration form on Webinar Resource page */ #gform_wrapper_96{ background: #001D2E; position: relative; z-index: 1; padding: 40px 20px; @include breakpoint(medium){ padding: 50px; padding-bottom: 30px; } .gfield_html{ text-align: center; color: #fff; h3{ margin-bottom: 12px; color: #A6A9FF; } } .gchoice label { color: #fff; margin-right: 0px; } .gfield_checkbox{ margin-bottom: 0px; } .button{ margin-top: 0px; display: block; width: 100%; } input, select{ color: #767676; font-weight: bold; } input[type="submit"]{ color: #fff; } } /* Event Agenda on Resource Pages */ .single-resources .symposium-agenda { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .single-resources .symposium-agenda .agenda-block { padding: 0px 40px; width: 100%; max-width: 996px; margin: auto; margin-top: 30px; background: #fff; border-top: solid 4px #6A6EF4; border-radius: 4px; box-shadow: 0px 5px 18px 0px rgba(106, 110, 244, 0.3); overflow: hidden; position: relative; } .single-resources .symposium-agenda .agenda-block__item { padding: 25px 0px; border-bottom: 1px solid rgba(118, 118, 118, 0.1); } .single-resources .symposium-agenda .agenda-block__item .item-title { color: #0067A6; font-size: 16px; line-height: 24px; } .single-resources .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .single-resources .speaker .headshot { display: block; width: 65px; height: 65px; border-radius: 50%; overflow: hidden; background: #f1f1f1; background-size: cover; background-position: center; margin-right: 14px; flex: 0 0 67px; } .single-resources .webinar-single-hosts { background: #F1F5FA; padding: 50px 0; padding-bottom: 100px; } .single-events .webinar-single-hosts h5 { margin-bottom: 45px; } .single-events .webinar-single-hosts .speaker { align-items: flex-start; } .single-events .speaker { display: flex; align-items: center; margin-bottom: 16px; padding-right: 16px; line-height: 1.2; } .single-resources .related-events { padding-top: 80px; } @media print, screen and (min-width: 64em) { .single-resources .symposium-agenda { padding: 70px 0; padding-bottom: 100px; } } @media print, screen and (min-width: 64em) { .single-resources .webinar-single-hosts { padding: 70px 0; padding-bottom: 100px; } } @media print, screen and (min-width: 64em) { .single-resources .related-events { padding-top: 110px; } } /* Resource Flexible Layouts */ /* Icon Item Row */ .single-resources .icon-item-row .icon-item { margin: 15px; display: flex; flex-direction: column; align-items: center; } .single-resources .icon-item-row .icon-item img { height: 70px; width: auto; margin-bottom: 15px; } .single-resources blockquote { font-size: inherit; padding-left: 30px; padding-right: 30px; } /*Sidebar Content Bullets */ .single-resources .flexible-sidebar-content .flexible-sidebar ul.fancy-list li .svg-inline--fa path { color: #fff !important; } /* Steps Block */ .single-resources .steps-block .content { padding: 60px 20px; color: #fff; background-size: cover; background-position: center; } @media print, screen and (min-width: 40em) .single-resources .steps-block .content .content-container { max-width: 22rem; margin-left: auto; margin-right: 2rem; } .single-resources .steps-block 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</div> <div class="cell medium-8 large-6 medium-order-1 button-color-orange"> <h5 class="color-orange" style="letter-spacing: 3px;"> <span class="badge">PhysChem Suite</span> Log<em>D</em> </h5> <h2><span style="color: #ffffff;">Distribution Coefficient Calculation</span></h2> <p><a class="button primary" href="#product_demo">Request a Consultation or Demo</a></p> </div> </div> </div> </section>  <div id="content-area" class="content-area"> <section class="overview"> <div class="grid-container"> <div class="grid-x"> <div class="cell text-center small-12"> <h5 class="section-heading">Log<em>D</em> Overview</h5> </div> <div class="cell medium-4"> <h2 class="h3">Predict the Distribution Coefficient from Structure</h2> </div> <div class="cell medium-8"> <p>ACD/Log<em>D</em> predicts the octanol-water distribution coefficient (or apparent partition coefficient) from a structure.</p> <p>Use ACD/Log<em>D</em> to:</p> <ul class="fancy-list"> <li>Calculate distribution coefficient values (log<em>D</em>) for all compound species of organic molecules at various pH</li> <li>View log<em>D</em> results at physiologically relevant pH values or discrete pH values of interest</li> <li>Train the algorithm with experimental measurements of log<em>P</em> and pK<sub>a</sub></li> </ul> </div> </div> </div> </section>  <section class="icon-item-row" id="benefits" data-menu="Benefits" data-magellan-target="benefits"> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell text-center "> <h5 class="section-heading color-orange">Benefits</h5> <h2 class="color-primary margin-auto" style="max-width: 650px">Everything You Need in a Log<i>D</i> Property Calculator</h2> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Quickly-Assess-the-Toxicity-of-Impurities-_-Degradants.png?fit=60%2C60&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Fast, Accurate & Reliable</span></h4> <ul class="fancy-list"> <li>Industry-standard calculators for pK<sub>a</sub> and log<em>P</em> provide a foundation for accurate log<em>D</em> calculation</li> <li>Evaluate the accuracy of results with the provided information—reliability index, five most similar structures in the database, and literature references for the original experimental data</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Deeper-Insights-3.png?fit=60%2C63&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Deeper Insights</span></h4> <ul class="fancy-list"> <li>Understand the behavior of your molecule with the automatically generated plot of log<em>D</em> versus pH</li> <li>Create scatter plots, browse, filter, sort, rank, and prioritize compounds with ease</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/06/icons-serveral-calculators.png?fit=102%2C139&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Several Calculators-in-One</span></h4> <ul class="fancy-list"> <li>Get several log<em>D</em> values by changing the combination of log<em>P</em> and pK<sub>a</sub> prediction algorithms to predict log<em>D</em>. Choose from three log<em>P</em> algorithms (Classic, GALAS, and Consensus), and two pK<sub>a</sub> algorithms (Classic and GALAS).</li> </ul> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Customizable-with-In-House-Data.png?fit=70%2C67&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Customizable with In-House Data</span></h4> <ul class="fancy-list"> <li>Get the accuracy of an in-house model from a commercial product. Use experimentally measured log<em>P</em> and pK<sub>a</sub> values to expand the applicability domain to proprietary chemical space.</li> <li>Build a training set per project for fine-tuned accuracy</li> </ul> </div> </div> </div> </div> </section><section class="views-slider-container" > <div class="grid-container"> <div class="cell"> <div class="views-slider arrow-color-orange"> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logD1.png?fit=1920%2C1080&quality=80&ssl=1" alt="" /> </div> <p class="caption">Calculate logD from chemical structure. See values at physiologically relevant pH, or define pH values of interest</p> </div> <div> <div class="view"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logD2.png?fit=1920%2C1080&quality=80&ssl=1" alt="" /> </div> <p class="caption">The software automatically identifies tautomers—choose to use the major or canonical form.</p> </div> </div> </div> </div> </section><section class="steps-block" style="background: #001D2E" id="how-it-works" data-menu="How it Works" data-magellan-target="how-it-works"> <div class="grid-container-fluid"> <div class="grid-x"> <div class="cell medium-5 content button-color-orange" style="background-image: url(https://www.acdlabs.com/wp-content/themes/acd-labs/lib/admin/images/flexible-defaults/How_it_works_img.png)"> <div class="content-container"> <h5 class="section-heading"><span style="color: #ff764c;">How it Works</span></h5> <h2 class="h4 h2"><span style="color: #ffffff;">Prediction in Seconds with Log<em>D</em></span></h2> <p><a class="button primary" href="#product_demo">Request a Consultation or Demo</a></p> </div> </div> <div class="cell medium-7 steps step-color-orange"> <div class="content-container"> <ul> <li> <span class="count">1</span> Draw/import your structure </li> <li> <span class="count">2</span> Review results and make decisions </li> <li> <span class="count">3</span> Report to PDF or copy/paste </li> </ul> </div> </div> </div> </div> </section> <section class="text-editor" style="background:#f1f5fa; " id="product-features" data-menu="Product Features" data-magellan-target="product-features"> <div class="grid-container"> <div class="grid-x main-color-orange button-color-orange"> <div class="cell text-center "> <h5 class="section-heading color-orange">Product Features</h5> <h2 class="color-primary">Distribution Coefficient (Log<em>D</em>) Calculator Features</h2> </div> <div class="cell medium-12 column"> <div class="faux-card"> <ul class="fancy-list"> <li data-gc-list-depth="1" data-gc-list-style="bullet">Predict log<em>D</em> from structure (draw in-app, or copy/paste from third-party drawing packages); SMILES string; InChI code; imported MOL, SK2, SKC, or CDX files; or search by name in the built-in dictionary</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Select from a variety of log<em>P</em> and pK<sub>a</sub> algorithms (default: log<em>P</em> Consensus, pK<sub>a</sub> Classic)</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">View log<em>D</em> values at different pH <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Physiologically relevant values (1.7, 4.6, 6.5, 7.4, 8.0)</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Click and drag across the plot (log<em>D</em> vs pH) for log<em>D</em> at a pH value of interest</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Add/remove predictions at a specific pH value</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Calculate log<em>D</em> properties for groups or libraries of compounds and use built-in tools to sort, filter, plot, and rank results. <ul> <li data-gc-list-depth="2" data-gc-list-style="bullet">Set user-defined label colors</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Filter results numerically</li> <li data-gc-list-depth="2" data-gc-list-style="bullet">Sort results by ascending/descending values</li> </ul> </li> <li data-gc-list-depth="1" data-gc-list-style="bullet">See results for previously calculated values in the history</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Report results to PDF</li> <li data-gc-list-depth="1" data-gc-list-style="bullet">Train the model with experimental values of log<em>P</em> and pK<sub>a</sub> to improve predictions for proprietary chemical space <ul class="fancy-list"> <li data-gc-list-depth="2" data-gc-list-style="bullet">Create and select different training libraries for calculations, or switch to the built-in algorithm</li> </ul> </li> </ul> </div> </div> </div> </div> </section><section class="icon-item-row" id="deployment-options" data-menu="Deployment Options" data-magellan-target="deployment-options"> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell text-center "> <h5 class="section-heading color-orange">Deployment/Integration Options</h5> <h2 class="color-primary margin-auto" style="max-width: 650px">Choose the Deployment Option That Works for You</h2> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Thick-Client-1.png?fit=63%2C55&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Desktop/Thick Client</span></h4> <p style="text-align: center;">Install ACD/Log<em>D</em> on individual computers to access the thick client, which provides a full graphical user interface and access to algorithm training tools.</p> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Batch-1.png?fit=65%2C63&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Batch</span></h4> <p style="text-align: center;">Calculate log<em>D</em> for tens of thousands of compounds with minimal user intervention. Batch deployment is compatible with Microsoft Windows and Linux. Plug-in to corporate intranets or workflow tools such as Pipeline Pilot.</p> </div> </div> <div class="cell medium-4 large-3"> <div class="icon-item list-color-orange"> <img src="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/Thin-Client-1.png?fit=61%2C62&quality=80&ssl=1" alt="" /> <h4 style="text-align: center;"><span style="color: #0067a6;">Percepta Portal/Thin Client</span></h4> <p style="text-align: center;">Use a browser-based application to predict log<em>D</em>. KNIME integration components are available. Host on your corporate intranet or the cloud. Available for Linux and Windows.</p> </div> </div> </div> </div> </section><section class="text-editor" style="background:#001d2e; " id="more-reasons-to-use" data-menu="More Reasons to Use" data-magellan-target="more-reasons-to-use"> <div class="grid-container"> <div class="grid-x main-color-orange button-color-orange"> <div class="cell text-center section-header"> <h5 class="section-heading color-orange">More Reasons to Use Log<em>D</em></h5> </div> <div class="cell medium-6 column"> <h2><span style="color: #ffffff;">Technical Information about Distribution Coefficient Prediction</span></h2> <div class="lightweight-accordion"><details open><summary class="lightweight-accordion-title"><h4>A Trainable Log<em>D</em> Calculator</h4></summary><div class="lightweight-accordion-body"><p><span style="color: #ffffff;">Train the log<em>D</em> algorithm by training the underlying log<em>P</em> and pK<sub>a</sub> models. Improve prediction accuracy and expand the applicability of the model to novel chemical space.</span></p> </div></details></div><br /> <div class="lightweight-accordion"><details><summary class="lightweight-accordion-title"><h4>How Are Log<em>D</em> Values Calculated?</h4></summary><div class="lightweight-accordion-body"><p><span style="color: #ffffff;">The distribution coefficient (log<em>D</em>) is the ratio of the sum of the concentrations of all forms of the compound (both neutral and ionized) in each of the two phases (octanol and an aqueous buffer). Each form has a different tendency to partition between aqueous buffer and n-octanol. This is characterized by a pH independent partitioning coefficient—log<em>P</em><sub>species</sub> (e.g., log<em>P</em><sub>0</sub>, log<em>P</em><sub>–</sub>, log<em>P</em><sub>2+</sub>, etc.).</span></p> <p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-5092" src="/www.acdlabs.com/wp-content/uploads/2022/03/download.png" alt="" width="177" height="53" srcset="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/03/download.png?w=177&quality=80&ssl=1 177w, https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/03/download.png?resize=150%2C45&quality=80&ssl=1 150w" sizes="(max-width: 177px) 100vw, 177px" /></p> <p><span style="color: #ffffff;">The log<em>D</em> prediction algorithm calculates partitioning constants based on the fragmental algorithm of log<em>P</em> for the neutral form and a series of correction factors, while considering the type and position of ionization. Log<em>D</em> is calculated as a function of the distribution of all molecular species, governed by pH as predicted by the pK<sub>a</sub>.</span></p> <p><span style="color: #ffffff;">ACD/Log<em>D</em> offers various algorithms for prediction of log<em>P</em> and pK<sub>a</sub> values and any combinations of these can be selected (and set as default) for prediction of log<em>D</em>.</span></p> </div></details></div></p> </div> <div class="cell medium-6 column"> <h2><span style="color: #ffffff;">General Information about Log<em>D</em></span></h2> <div class="lightweight-accordion"><details open><summary class="lightweight-accordion-title"><h4>What Is the Distribution Coefficient?</h4></summary><div class="lightweight-accordion-body"><p><span style="color: #ffffff;">The distribution constant (<em>D</em>), also known as the apparent partition coefficient, is a measure of the hydrophilicity (‘aqueous-loving’) or hydrophobicity (‘aqueous-fearing’) an ionizable molecule is. It represents the tendency of a compound to differentially dissolve in two immiscible phases (typically octanol and aqueous buffer), while considering the distribution of ionized species based on pH. It is also referred to as the distribution coefficient. For example, see the partitioning of methylamine in octanol-water and how the distribution constant describes the partitioning:</span></p> <p><span style="color: #ffffff;"><img loading="lazy" decoding="async" class="size-full wp-image-2508 aligncenter" src="/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation2-1.png" alt="" width="233" height="31" srcset="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation2-1.png?w=233&quality=80&ssl=1 233w, https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation2-1.png?resize=150%2C20&quality=80&ssl=1 150w" sizes="(max-width: 233px) 100vw, 233px" /></span></p> <p><span style="color: #ffffff;"> <img loading="lazy" decoding="async" class="size-full wp-image-2509 aligncenter" src="/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation3-1.png" alt="" width="243" height="48" srcset="https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation3-1.png?w=243&quality=80&ssl=1 243w, https://i0.wp.com/www.acdlabs.com/wp-content/uploads/2022/01/logd_equation3-1.png?resize=150%2C30&quality=80&ssl=1 150w" sizes="(max-width: 243px) 100vw, 243px" /></span></p> <p><span style="color: #ffffff;">Log<em>D</em> prediction models estimate the distribution constant as a logarithmic ratio (log<em>D </em>or Clog<em>D</em>). The distribution coefficient acts as a quantitative descriptor of the lipophilicity (or hydrophobicity) of ionizable compounds.</span></p> </div></details></div><br /> <div class="lightweight-accordion"><details><summary class="lightweight-accordion-title"><h4>How Are Log<em>D</em> Values Used?</h4></summary><div class="lightweight-accordion-body"><p><span style="color: #ffffff;">Drug Discovery—Log<em>D</em> values are used to understand and predict the<em> in-vivo</em> behavior of an active compound under physiological conditions. Since the pH environment is very different throughout the gastrointestinal tract (ranging from 1.4 in the stomach to 8 in the colon) understanding the lipophilicity/hydrophilicity of a drug lead under physiological conditions helps scientists understand behavior under substantially different chemical environs.</span></p> <p><img decoding="async" draggable="false" 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" /></p> <p><span style="color: #ffffff;">Log<em>D</em> values are also important in chromatographic method development (for selection of the appropriate pH and separation columns); in agrochemistry to develop herbicides and insecticides; in environmental chemistry to understand the behavior of pollutants, and in the development of many other consumer products.</span></p> </div></details></div></p> </div> </div> </div> </section><section class="text-editor" style="background:; " id="whats-new" data-menu="What's New" data-magellan-target="whats-new"> <div class="grid-container"> <div class="grid-x main-color-orange button-color-orange"> <div class="cell text-center "> <h5 class="section-heading color-orange">What's New!</h5> <h2 class="color-primary">What's New in Log<em>D</em> Version 2024</h2> </div> <div class="cell medium-6 column"> <ul class="fancy-list"> <li>Technical improvements to the log<em>D</em> algorithm leading to a more accurate shape of the simulated log<em>D vs </em>pH curve relative to the plot expected from the compound’s apparent pK<sub>a</sub> profile</li> </ul> </div> <div class="cell medium-6 column"> <ul class="fancy-list"> <li>Enhanced accuracy of log<em>D</em> predictions and water solubility pH profile resulting from significant improvements to pK<sub>a</sub> and log<em>P</em> prediction algorithms</li> </ul> </div> <div class="cell medium-12 column"> <p style="text-align: center;"><a class="button primary" href="/technical-support/current-software-versions/physchem-suite/">Read the Full List of What’s New</a></p> </div> </div> </div> </section><section class="sorted-posts" id="learn-more" data-menu="Learn More" data-magellan-target="learn-more"> <div class="grid-container"> <div class="grid-x"> <div class="cell" style="padding-left: 15px;"> <h5 class="section-heading color-orange">Learn More about Log<i>D</i></h5> </div> </div> <div class="grid-x related_posts"> <div class="cell sorted-post-filters color-orange show-for-medium"> <button class="sorted-posts-filter is-active" data-filter="all"> All Resources</button> <button class="sorted-posts-filter" data-filter="technical-documents"><i class="fas fa-file-alt"></i>Technical Documents</button> <button class="sorted-posts-filter" data-filter="press-release"><i class="fas fa-newspaper"></i>Press Releases</button> <button class="sorted-posts-filter" data-filter="blog"><i class="fas fa-comment-alt"></i>Blog</button> <button class="sorted-posts-filter" data-filter="presentations"><i class="fas fa-presentation"></i>Presentations</button> <button class="sorted-posts-filter" data-filter="appnote"><i class="fas fa-file-contract"></i>Application Notes</button> </div> <div class="cell medium-6 large-4 sorted-posts-item technical-documents color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-alt"></i>Technical Documents</span> <a target="_blank" href="https://www.acdlabs.com/resource/improved-algorithm-for-logd-calculation-within-the-percepta-platform/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/improved-algorithm-for-logd-calculation-within-the-percepta-platform/" class="content"> <h4>Improved Algorithm for Log<em>D</em> Calculation Within the Percepta® Platform</h4> <p>Our algorithm for calculating pH-dependent octanol/water distribution coefficient (logD) is a highly accurate and robust method to evaluate lipophilicity of drug-like molecules at a variety of physiologically relevant conditions.</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/improved-algorithm-for-logd-calculation-within-the-percepta-platform/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item press-release color-orange"> <div class="card"> <span class="badge"><i class="fas fa-newspaper"></i>Press Releases</span> <a href="https://www.acdlabs.com/resource/acd-labs-releases-v2024-of-modeling-platform-percepta-to-support-pharmaceutical-and-chemical-rd-at-the-physchem-forum/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/acd-labs-releases-v2024-of-modeling-platform-percepta-to-support-pharmaceutical-and-chemical-rd-at-the-physchem-forum/" class="content"> <h4>ACD/Labs Releases v2024 of Modeling Platform Percepta® to Support Pharmaceutical and Chemical R&D at the PhysChem Forum</h4> <p>Version 2024 of Percepta delivers substantial expansions to the training sets and algorithms, improving prediction accuracy for pKa and logP calculators, and a range of ADME and toxicity endpoints. This update also increases coverage of chemical space occupied by new therapeutic modalities such as proteolysis targeting chimeras (PROTACs).</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/acd-labs-releases-v2024-of-modeling-platform-percepta-to-support-pharmaceutical-and-chemical-rd-at-the-physchem-forum/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item blog color-orange"> <div class="card"> <span class="badge"><i class="fas fa-comment-alt"></i>Blog</span> <a href="https://www.acdlabs.com/blog/partitioning-logp-or-logd-are-you-using-measuring-the-right-descriptor/" class="content"> <a target="_blank" href="https://www.acdlabs.com/blog/partitioning-logp-or-logd-are-you-using-measuring-the-right-descriptor/" class="content"> <h4>LogP vs LogD – What is the Difference?</h4> <p><p>Log<em>P</em> and log<em>D</em> are important values to consider during the drug design process as both give insight to the lipophilicity and hydrophilicity of compounds.</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/blog/partitioning-logp-or-logd-are-you-using-measuring-the-right-descriptor/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item presentations color-orange"> <div class="card"> <span class="badge"><i class="fas fa-presentation"></i>Presentations</span> <a href="https://www.acdlabs.com/resource/collaborations-developments-that-bring-you-industry-leading-predictive-pka/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/collaborations-developments-that-bring-you-industry-leading-predictive-pka/" class="content"> <h4>Collaborations & Developments that Bring You Industry-Leading Predictive pKa</h4>K. Lanevskij, ACD/Labs <p>Hear about collaborations with pharma and chemical companies that have helped enhance ACD/Labs industry-standard pKa algorithms, particularly the significant upgrades in speed, accuracy, and reduction of normalization errors in v2023.</p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/collaborations-developments-that-bring-you-industry-leading-predictive-pka/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item presentations color-orange"> <div class="card"> <span class="badge"><i class="fas fa-presentation"></i>Presentations</span> <a href="https://www.acdlabs.com/resource/accounting-for-ionization-in-the-increasingly-digital-rd-paradigm/" class="content"> <a target="_blank" href="https://www.acdlabs.com/resource/accounting-for-ionization-in-the-increasingly-digital-rd-paradigm/" class="content"> <h4>Accounting for Ionization in the Increasingly Digital R&D Paradigm</h4>A. Anderson, ACD/Labs <p><p>The prevalence of ionizable compounds in pharmaceuticals makes pKa an important physicochemical property to consider in drug discovery and development….</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/resource/accounting-for-ionization-in-the-increasingly-digital-rd-paradigm/"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item appnote color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-contract"></i>Application Notes</span> <a target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/admet/appnote_trainingpred.pdf" class="content"> <a target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/admet/appnote_trainingpred.pdf" class="content"> <h4>The Importance of Training Predictors</h4> <p><p>This application note discusses the importance of using the machine learning (model training) capabilities of predictive models to improve accuracy.</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/admet/appnote_trainingpred.pdf"><i class="far fa-arrow-right"></i></a> </div> </div> <div class="cell medium-6 large-4 sorted-posts-item appnote color-orange"> <div class="card"> <span class="badge"><i class="fas fa-file-contract"></i>Application Notes</span> <a target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/physchem/logp_vs_logd.pdf" class="content"> <a target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/physchem/logp_vs_logd.pdf" class="content"> <h4>Lipophilicity Descriptors: Understanding When to Use Log<em>P</em> & Log<em>D</em></h4> <p><p>LogP vs logD? Learn why logD is the most relevant lipophilicity descriptor in R&D and see how it may be…</p> </p> </a> <a class="arrow" target="_blank" href="https://www.acdlabs.com/wp-content/uploads/download/app/physchem/logp_vs_logd.pdf"><i class="far fa-arrow-right"></i></a> </div> </div> </div> </div> </section><section class="demo-cta form-color-orange" id="contact-us" data-menu="Contact Us" data-magellan-target="contact-us"> <div class="anchor"><span id="product_demo"></span></div> <div class="background" style="background-image: url(https://www.acdlabs.com/wp-content/themes/acd-labs/lib/admin/images/flexible-defaults/demoBackground.jpg)"></div> <div class="grid-container"> <div class="grid-x align-center"> <div class="cell medium-8 large-5"> <script data-jetpack-boost="ignore" type="text/javascript"></script> <div class='gf_browser_safari gform_wrapper gravity-theme gform-theme--no-framework' data-form-theme='gravity-theme' data-form-index='0' id='gform_wrapper_3' style='display:none'><div id='gf_3' class='gform_anchor' tabindex='-1'></div><form method='post' enctype='multipart/form-data' target='gform_ajax_frame_3' id='gform_3' action='/products/percepta-platform/physchem-suite/logd/#gf_3' data-formid='3' novalidate> <div class='gform-body gform_body'><div id='gform_fields_3' class='gform_fields top_label form_sublabel_below description_below validation_below'><div id="field_3_6" class="gfield gfield--type-text gfield--input-type-text gfield--width-full field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_hidden" data-js-reload="field_3_6" ><div class='admin-hidden-markup'><i class='gform-icon gform-icon--hidden'></i><span>Hidden</span></div><label class='gfield_label gform-field-label' for='input_3_6'>Demo Request For:</label><div class='ginput_container ginput_container_text'><input name='input_6' id='input_3_6' type='text' value='Log<em>D</em>' class='large' aria-invalid="false" /> </div></div><div id="field_3_2" class="gfield gfield--type-html gfield--input-type-html gfield--width-full gfield_html gfield_html_formatted gfield_no_follows_desc field_sublabel_below gfield--no-description field_description_below field_validation_below gfield_visibility_visible" data-js-reload="field_3_2" ><h3>Request a Consultation & Demo</h3> <p>Contact us to arrange for a demonstration of our software, or to get answers to any questions you may have.</p></div><fieldset id="field_3_7" class="gfield gfield--type-name gfield--input-type-name gfield--width-full gfield_contains_required field_sublabel_hidden_label gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_7" ><legend class='gfield_label gform-field-label gfield_label_before_complex' >Name<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></legend><div class='ginput_complex ginput_container ginput_container--name no_prefix has_first_name no_middle_name has_last_name no_suffix gf_name_has_2 ginput_container_name gform-grid-row' id='input_3_7'> <span id='input_3_7_3_container' class='name_first gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_7.3' id='input_3_7_3' value='' aria-required='true' placeholder='First Name*' /> <label for='input_3_7_3' class='gform-field-label gform-field-label--type-sub hidden_sub_label screen-reader-text'>First</label> </span> <span id='input_3_7_6_container' class='name_last gform-grid-col gform-grid-col--size-auto' > <input type='text' name='input_7.6' id='input_3_7_6' value='' aria-required='true' placeholder='Last Name*' /> <label for='input_3_7_6' class='gform-field-label gform-field-label--type-sub hidden_sub_label screen-reader-text'>Last</label> </span> </div></fieldset><div id="field_3_3" class="gfield gfield--type-email gfield--input-type-email gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_3" ><label class='gfield_label gform-field-label' for='input_3_3'>Email<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_email'> <input name='input_3' id='input_3_3' type='email' value='' class='large' placeholder='Email*' aria-required="true" aria-invalid="false" /> </div></div><div id="field_3_8" class="gfield gfield--type-text gfield--input-type-text gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_8" ><label class='gfield_label gform-field-label' for='input_3_8'>Company<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_text'><input name='input_8' id='input_3_8' type='text' value='' class='large' placeholder='Company*' aria-required="true" aria-invalid="false" /> </div></div><div id="field_3_9" class="gfield gfield--type-select gfield--input-type-select gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_9" ><label class='gfield_label gform-field-label' for='input_3_9'>Country<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_select'><select name='input_9' id='input_3_9' class='large gfield_select' aria-required="true" aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Country*</option><option value='Afghanistan' >Afghanistan</option><option value='Albania' >Albania</option><option value='Algeria' >Algeria</option><option value='American Samoa' >American Samoa</option><option value='Andorra' >Andorra</option><option value='Angola' >Angola</option><option value='Anguilla' >Anguilla</option><option value='Antarctica' >Antarctica</option><option value='Antigua and Barbuda' >Antigua and Barbuda</option><option value='Argentina' >Argentina</option><option value='Armenia' >Armenia</option><option value='Aruba' >Aruba</option><option value='Australia' >Australia</option><option value='Austria' >Austria</option><option value='Azerbaijan' >Azerbaijan</option><option value='Bahamas' >Bahamas</option><option value='Bahrain' >Bahrain</option><option value='Bangladesh' >Bangladesh</option><option value='Barbados' >Barbados</option><option value='Belarus' >Belarus</option><option value='Belgium' >Belgium</option><option value='Belize' >Belize</option><option value='Benin' >Benin</option><option value='Bermuda' >Bermuda</option><option value='Bhutan' >Bhutan</option><option value='Bolivia' >Bolivia</option><option value='Bosnia and Herzegovina' >Bosnia and Herzegovina</option><option value='Botswana' >Botswana</option><option value='Bouvet Island' >Bouvet Island</option><option value='Brazil' >Brazil</option><option value='British Indian Ocean Territory' >British Indian Ocean Territory</option><option value='Brunei Darussalam' >Brunei Darussalam</option><option value='Bulgaria' >Bulgaria</option><option value='Burkina Faso' >Burkina Faso</option><option value='Burundi' >Burundi</option><option value='Cambodia' >Cambodia</option><option value='Cameroon' >Cameroon</option><option value='Canada' >Canada</option><option value='Cape Verde' >Cape Verde</option><option value='Cayman Islands' >Cayman Islands</option><option value='Central African Republic' >Central African Republic</option><option value='Chad' >Chad</option><option value='Chile' >Chile</option><option value='China' >China</option><option value='Christmas Island' >Christmas Island</option><option value='Cocos (Keeling) Islands' >Cocos (Keeling) Islands</option><option value='Colombia' >Colombia</option><option value='Comoros' >Comoros</option><option value='Congo' >Congo</option><option value='Congo, The Democratic Republic of the' >Congo, The Democratic Republic of the</option><option value='Cook Islands' >Cook Islands</option><option value='Costa Rica' >Costa Rica</option><option value='Croatia' >Croatia</option><option value='Cuba' >Cuba</option><option value='Curaçao' >Curaçao</option><option value='Cyprus' >Cyprus</option><option value='Czech Republic' >Czech Republic</option><option value='Cote d'Ivoire' >Cote d'Ivoire</option><option value='Denmark' >Denmark</option><option value='Djibouti' >Djibouti</option><option value='Dominica' >Dominica</option><option value='Dominican Republic' >Dominican Republic</option><option value='East Timor' >East Timor</option><option value='Ecuador' >Ecuador</option><option value='Egypt' >Egypt</option><option value='El Salvador' >El Salvador</option><option value='Equatorial Guinea' >Equatorial Guinea</option><option value='Eritrea' >Eritrea</option><option value='Estonia' >Estonia</option><option value='Ethiopia' >Ethiopia</option><option value='Falkland Islands (Malvinas)' >Falkland Islands (Malvinas)</option><option value='Faroe Islands' >Faroe Islands</option><option value='Fiji' >Fiji</option><option value='Finland' >Finland</option><option value='France' >France</option><option value='French Guiana' >French Guiana</option><option value='French Polynesia' >French Polynesia</option><option value='French Southern Territories' >French Southern Territories</option><option value='Gabon' >Gabon</option><option value='Gambia' >Gambia</option><option value='Georgia' >Georgia</option><option value='Germany' >Germany</option><option value='Ghana' >Ghana</option><option value='Gibraltar' >Gibraltar</option><option value='Greece' >Greece</option><option value='Greenland' >Greenland</option><option value='Grenada' >Grenada</option><option value='Guadeloupe' >Guadeloupe</option><option value='Guam' >Guam</option><option value='Guatemala' >Guatemala</option><option value='Guernsey' >Guernsey</option><option value='Guinea' >Guinea</option><option value='Guinea-Bissau' >Guinea-Bissau</option><option value='Guyana' >Guyana</option><option value='Haiti' >Haiti</option><option value='Heard Island and McDonald Islands' >Heard Island and McDonald Islands</option><option value='Holy See (Vatican City)' >Holy See (Vatican City)</option><option value='Honduras' >Honduras</option><option value='Hong Kong' >Hong Kong</option><option value='Hungary' >Hungary</option><option value='Iceland' >Iceland</option><option value='India' >India</option><option value='Indonesia' >Indonesia</option><option value='Iran' >Iran</option><option value='Iraq' >Iraq</option><option value='Ireland' >Ireland</option><option value='Isle of Man' >Isle of Man</option><option value='Israel' >Israel</option><option value='Italy' >Italy</option><option value='Jamaica' >Jamaica</option><option value='Japan' >Japan</option><option value='Jersey' >Jersey</option><option value='Jordan' >Jordan</option><option value='Kazakhstan' >Kazakhstan</option><option value='Kenya' >Kenya</option><option value='Kiribati' >Kiribati</option><option value='Kuwait' >Kuwait</option><option value='Kyrgyzstan' >Kyrgyzstan</option><option value='Laos' >Laos</option><option value='Latvia' >Latvia</option><option value='Lebanon' >Lebanon</option><option value='Lesotho' >Lesotho</option><option value='Liberia' >Liberia</option><option value='Libya' >Libya</option><option value='Liechtenstein' >Liechtenstein</option><option value='Lithuania' >Lithuania</option><option value='Luxembourg' >Luxembourg</option><option value='Macau' >Macau</option><option value='Macedonia' >Macedonia</option><option value='Madagascar' >Madagascar</option><option value='Malawi' >Malawi</option><option value='Malaysia' >Malaysia</option><option value='Maldives' >Maldives</option><option value='Mali' >Mali</option><option value='Malta' >Malta</option><option value='Marshall Islands' >Marshall Islands</option><option value='Martinique' >Martinique</option><option value='Mauritania' >Mauritania</option><option value='Mauritius' >Mauritius</option><option value='Mayotte' >Mayotte</option><option value='Mexico' >Mexico</option><option value='Micronesia, Federated States of' >Micronesia, Federated States of</option><option value='Moldova' >Moldova</option><option value='Monaco' >Monaco</option><option value='Mongolia' >Mongolia</option><option value='Montenegro' >Montenegro</option><option value='Montserrat' >Montserrat</option><option value='Morocco' >Morocco</option><option value='Mozambique' >Mozambique</option><option value='Myanmar' >Myanmar</option><option value='Namibia' >Namibia</option><option value='Nauru' >Nauru</option><option value='Nepal' >Nepal</option><option value='Netherlands' >Netherlands</option><option value='New Caledonia' >New Caledonia</option><option value='New Zealand' >New Zealand</option><option value='Nicaragua' >Nicaragua</option><option value='Niger' >Niger</option><option value='Nigeria' >Nigeria</option><option value='Niue' >Niue</option><option value='Norfolk Island' >Norfolk Island</option><option value='North Korea' >North Korea</option><option value='Northern Mariana Islands' >Northern Mariana Islands</option><option value='Norway' >Norway</option><option value='Oman' >Oman</option><option value='Pakistan' >Pakistan</option><option value='Palau' >Palau</option><option value='Palestine' >Palestine</option><option value='Panama' >Panama</option><option value='Papua New Guinea' >Papua New Guinea</option><option value='Paraguay' >Paraguay</option><option value='Peru' >Peru</option><option value='Philippines' >Philippines</option><option value='Pitcairn Islands' >Pitcairn Islands</option><option value='Poland' >Poland</option><option value='Portugal' >Portugal</option><option value='Puerto Rico' >Puerto Rico</option><option value='Qatar' >Qatar</option><option value='Romania' >Romania</option><option value='Russia' >Russia</option><option value='Rwanda' >Rwanda</option><option value='Reunion' >Reunion</option><option value='Saint Barthélemy' >Saint Barthélemy</option><option value='Saint Helena' >Saint Helena</option><option value='Saint Kitts and Nevis' >Saint Kitts and Nevis</option><option value='Saint Lucia' >Saint Lucia</option><option value='Saint Martin' >Saint Martin</option><option value='Saint Pierre and Miquelon' >Saint Pierre and Miquelon</option><option value='Saint Vincent and the Grenadines' >Saint Vincent and the Grenadines</option><option value='Samoa' >Samoa</option><option value='San Marino' >San Marino</option><option value='Sao Tome and Principe' >Sao Tome and Principe</option><option value='Saudi Arabia' >Saudi Arabia</option><option value='Senegal' >Senegal</option><option value='Serbia' >Serbia</option><option value='Seychelles' >Seychelles</option><option value='Sierra Leone' >Sierra Leone</option><option value='Singapore' >Singapore</option><option value='Sint Maarten' >Sint Maarten</option><option value='Slovakia' >Slovakia</option><option value='Slovenia' >Slovenia</option><option value='Solomon Islands' >Solomon Islands</option><option value='Somalia' >Somalia</option><option value='South Africa' >South Africa</option><option value='South Georgia and The South Sandwich Islands' >South Georgia and The South Sandwich Islands</option><option value='South Korea' >South Korea</option><option value='South Sudan' >South Sudan</option><option value='Spain' >Spain</option><option value='Sri Lanka' >Sri Lanka</option><option value='Sudan' >Sudan</option><option value='Suriname' >Suriname</option><option value='Svalbard and Jan Mayen' >Svalbard and Jan Mayen</option><option value='Swaziland' >Swaziland</option><option value='Sweden' >Sweden</option><option value='Switzerland' >Switzerland</option><option value='Syria' >Syria</option><option value='Taiwan' >Taiwan</option><option value='Tajikistan' >Tajikistan</option><option value='Tanzania, United Republic of' >Tanzania, United Republic of</option><option value='Thailand' >Thailand</option><option value='Togo' >Togo</option><option value='Tokelau' >Tokelau</option><option value='Tonga' >Tonga</option><option value='Trinidad and Tobago' >Trinidad and Tobago</option><option value='Tunisia' >Tunisia</option><option value='Turkey' >Turkey</option><option value='Turkmenistan' >Turkmenistan</option><option value='Turks and Caicos Islands' >Turks and Caicos Islands</option><option value='Tuvalu' >Tuvalu</option><option value='United States Minor Outlying Islands' >United States Minor Outlying Islands</option><option value='Uganda' >Uganda</option><option value='Ukraine' >Ukraine</option><option value='United Arab Emirates' >United Arab Emirates</option><option value='United Kingdom' >United Kingdom</option><option value='United States' >United States</option><option value='Uruguay' >Uruguay</option><option value='Uzbekistan' >Uzbekistan</option><option value='Vanuatu' >Vanuatu</option><option value='Venezuela' >Venezuela</option><option value='Viet Nam' >Viet Nam</option><option value='Virgin Islands, British' >Virgin Islands, British</option><option value='Virgin Islands, U.S.' >Virgin Islands, U.S.</option><option value='Wallis and Futuna' >Wallis and Futuna</option><option value='Western Sahara' >Western Sahara</option><option value='Yemen' >Yemen</option><option value='Zambia' >Zambia</option><option value='Zimbabwe' >Zimbabwe</option></select></div></div><div id="field_3_11" class="gfield gfield--type-select gfield--input-type-select gfield--width-half gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_11" ><label class='gfield_label gform-field-label' for='input_3_11'>Province/State (CAN)<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_select'><select name='input_11' id='input_3_11' class='large gfield_select' aria-required="true" aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Province/State*</option><option value='Alberta' >Alberta</option><option value='British Columbia' >British Columbia</option><option value='Manitoba' >Manitoba</option><option value='New Brunswick' >New Brunswick</option><option value='Newfoundland and Labrador' >Newfoundland and Labrador</option><option value='Northwest Territories' >Northwest Territories</option><option value='Nova Scotia' >Nova Scotia</option><option value='Nunavut' >Nunavut</option><option value='Ontario' >Ontario</option><option value='Prince Edward Island' >Prince Edward Island</option><option value='Quebec' >Quebec</option><option value='Saskatchewan' >Saskatchewan</option><option value='Yukon' >Yukon</option></select></div></div><div id="field_3_12" class="gfield gfield--type-select gfield--input-type-select gfield--width-half field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_12" ><label class='gfield_label gform-field-label' for='input_3_12'>Province/State (US)</label><div class='ginput_container ginput_container_select'><select name='input_12' id='input_3_12' class='large gfield_select' aria-invalid="false" ><option value='' selected='selected' class='gf_placeholder'>Province/State*</option><option value='Alabama' >Alabama</option><option value='Alaska' >Alaska</option><option value='Arizona' >Arizona</option><option value='Arkansas' >Arkansas</option><option value='California' >California</option><option value='Colorado' >Colorado</option><option value='Connecticut' >Connecticut</option><option value='Delaware' >Delaware</option><option value='District of Columbia' >District of Columbia</option><option value='Florida' >Florida</option><option value='Georgia' >Georgia</option><option value='Hawaii' >Hawaii</option><option value='Idaho' >Idaho</option><option value='Illinois' >Illinois</option><option value='Indiana' >Indiana</option><option value='Iowa' >Iowa</option><option value='Kansas' >Kansas</option><option value='Kentucky' >Kentucky</option><option value='Louisiana' >Louisiana</option><option value='Maine' >Maine</option><option value='Maryland' >Maryland</option><option value='Massachusetts' >Massachusetts</option><option value='Michigan' >Michigan</option><option value='Minnesota' >Minnesota</option><option value='Mississippi' >Mississippi</option><option value='Missouri' >Missouri</option><option value='Montana' >Montana</option><option value='Nebraska' >Nebraska</option><option value='Nevada' >Nevada</option><option value='New Hampshire' >New Hampshire</option><option value='New Jersey' >New Jersey</option><option value='New Mexico' >New Mexico</option><option value='New York' >New York</option><option value='North Carolina' >North Carolina</option><option value='North Dakota' >North Dakota</option><option value='Ohio' >Ohio</option><option value='Oklahoma' >Oklahoma</option><option value='Oregon' >Oregon</option><option value='Pennsylvania' >Pennsylvania</option><option value='Rhode Island' >Rhode Island</option><option value='South Carolina' >South Carolina</option><option value='South Dakota' >South Dakota</option><option value='Tennessee' >Tennessee</option><option value='Texas' >Texas</option><option value='Utah' >Utah</option><option value='Vermont' >Vermont</option><option value='Virginia' >Virginia</option><option value='Washington' >Washington</option><option value='West Virginia' >West Virginia</option><option value='Wisconsin' >Wisconsin</option><option value='Wyoming' >Wyoming</option><option value='Armed Forces Americas' >Armed Forces Americas</option><option value='Armed Forces Europe' >Armed Forces Europe</option><option value='Armed Forces Pacific' >Armed Forces Pacific</option></select></div></div><div id="field_3_5" class="gfield gfield--type-textarea gfield--input-type-textarea gfield--width-full gfield_contains_required field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_5" ><label class='gfield_label gform-field-label' for='input_3_5'>Message<span class="gfield_required"><span class="gfield_required gfield_required_text">(Required)</span></span></label><div class='ginput_container ginput_container_textarea'><textarea name='input_5' id='input_3_5' class='textarea small' placeholder='Message*' aria-required="true" aria-invalid="false" rows='10' cols='50'></textarea></div></div><fieldset id="field_3_13" class="gfield gfield--type-checkbox gfield--type-choice gfield--input-type-checkbox gfield--width-full field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" data-js-reload="field_3_13" ><legend class='gfield_label gform-field-label gfield_label_before_complex' >Consent</legend><div class='ginput_container ginput_container_checkbox'><div class='gfield_checkbox' id='input_3_13'><div class='gchoice gchoice_3_13_1'> <input class='gfield-choice-input' name='input_13.1' type='checkbox' value='Yes' id='choice_3_13_1' /> <label for='choice_3_13_1' id='label_3_13_1' class='gform-field-label gform-field-label--type-inline'>I consent to receiving email from ACD/Labs</label> </div></div></div></fieldset><fieldset id="field_3_15" class="gfield gfield--type-checkbox gfield--type-choice gfield--input-type-checkbox gfield--width-full field_sublabel_below gfield--no-description field_description_below hidden_label field_validation_below gfield_visibility_visible" 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Not consenting or withdrawing consent, may adversely affect certain features and functions.</div>  <div class="cmplz-categories"> <details class="cmplz-category cmplz-functional" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Functional</span> <span class='cmplz-always-active'> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-functional-optin" data-category="cmplz_functional" class="cmplz-consent-checkbox cmplz-functional" size="40" value="1"/> <label class="cmplz-label" for="cmplz-functional-optin" tabindex="0"><span class="screen-reader-text">Functional</span></label> </span> Always active </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-functional">The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.</span> </div> </details> <details class="cmplz-category cmplz-preferences" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Preferences</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-preferences-optin" data-category="cmplz_preferences" class="cmplz-consent-checkbox cmplz-preferences" size="40" value="1"/> <label class="cmplz-label" for="cmplz-preferences-optin" tabindex="0"><span class="screen-reader-text">Preferences</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-preferences">The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.</span> </div> </details> <details class="cmplz-category cmplz-statistics" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Statistics</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-statistics-optin" data-category="cmplz_statistics" class="cmplz-consent-checkbox cmplz-statistics" size="40" value="1"/> <label class="cmplz-label" for="cmplz-statistics-optin" tabindex="0"><span class="screen-reader-text">Statistics</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-statistics">The technical storage or access that is used exclusively for statistical purposes.</span> <span class="cmplz-description-statistics-anonymous">The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.</span> </div> </details> <details class="cmplz-category cmplz-marketing" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Marketing</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-marketing-optin" data-category="cmplz_marketing" class="cmplz-consent-checkbox cmplz-marketing" size="40" value="1"/> <label class="cmplz-label" for="cmplz-marketing-optin" tabindex="0"><span class="screen-reader-text">Marketing</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-marketing">The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.</span> </div> </details> </div> </div> <div class="cmplz-links cmplz-information"> <a class="cmplz-link cmplz-manage-options cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">Manage options</a> <a class="cmplz-link cmplz-manage-third-parties cookie-statement" href="#" data-relative_url="#cmplz-cookies-overview">Manage services</a> <a class="cmplz-link cmplz-manage-vendors tcf cookie-statement" href="#" data-relative_url="#cmplz-tcf-wrapper">Manage {vendor_count} vendors</a> <a class="cmplz-link cmplz-external cmplz-read-more-purposes tcf" target="_blank" rel="noopener noreferrer nofollow" href="https://cookiedatabase.org/tcf/purposes/">Read more about these purposes</a> </div> <div class="cmplz-divider cmplz-footer"></div> <div class="cmplz-buttons"> <button class="cmplz-btn cmplz-accept">Accept</button> <button class="cmplz-btn cmplz-deny">Deny</button> <button class="cmplz-btn cmplz-view-preferences">View preferences</button> <button class="cmplz-btn cmplz-save-preferences">Save preferences</button> <a class="cmplz-btn cmplz-manage-options tcf cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">View preferences</a> </div> <div class="cmplz-links cmplz-documents"> <a class="cmplz-link cookie-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link privacy-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link impressum" href="#" data-relative_url="">{title}</a> </div> </div> <div class="cmplz-cookiebanner cmplz-hidden banner-1 banner-a optout cmplz-bottom-right cmplz-categories-type-view-preferences" aria-modal="true" data-nosnippet="true" role="dialog" aria-live="polite" aria-labelledby="cmplz-header-1-optout" aria-describedby="cmplz-message-1-optout"> <div class="cmplz-header"> <div class="cmplz-logo"></div> <div class="cmplz-title" id="cmplz-header-1-optout">Manage Consent</div> <div class="cmplz-close" tabindex="0" role="button" aria-label="Close dialog"> <svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="times" class="svg-inline--fa fa-times fa-w-11" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 352 512"><path fill="currentColor" d="M242.72 256l100.07-100.07c12.28-12.28 12.28-32.19 0-44.48l-22.24-22.24c-12.28-12.28-32.19-12.28-44.48 0L176 189.28 75.93 89.21c-12.28-12.28-32.19-12.28-44.48 0L9.21 111.45c-12.28 12.28-12.28 32.19 0 44.48L109.28 256 9.21 356.07c-12.28 12.28-12.28 32.19 0 44.48l22.24 22.24c12.28 12.28 32.2 12.28 44.48 0L176 322.72l100.07 100.07c12.28 12.28 32.2 12.28 44.48 0l22.24-22.24c12.28-12.28 12.28-32.19 0-44.48L242.72 256z"></path></svg> </div> </div> <div class="cmplz-divider cmplz-divider-header"></div> <div class="cmplz-body"> <div class="cmplz-message" id="cmplz-message-1-optout">To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.</div>  <div class="cmplz-categories"> <details class="cmplz-category cmplz-functional" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Functional</span> <span class='cmplz-always-active'> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-functional-optout" data-category="cmplz_functional" class="cmplz-consent-checkbox cmplz-functional" size="40" value="1"/> <label class="cmplz-label" for="cmplz-functional-optout" tabindex="0"><span class="screen-reader-text">Functional</span></label> </span> Always active </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-functional">The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.</span> </div> </details> <details class="cmplz-category cmplz-preferences" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Preferences</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-preferences-optout" data-category="cmplz_preferences" class="cmplz-consent-checkbox cmplz-preferences" size="40" value="1"/> <label class="cmplz-label" for="cmplz-preferences-optout" tabindex="0"><span class="screen-reader-text">Preferences</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-preferences">The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.</span> </div> </details> <details class="cmplz-category cmplz-statistics" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Statistics</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-statistics-optout" data-category="cmplz_statistics" class="cmplz-consent-checkbox cmplz-statistics" size="40" value="1"/> <label class="cmplz-label" for="cmplz-statistics-optout" tabindex="0"><span class="screen-reader-text">Statistics</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-statistics">The technical storage or access that is used exclusively for statistical purposes.</span> <span class="cmplz-description-statistics-anonymous">The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.</span> </div> </details> <details class="cmplz-category cmplz-marketing" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Marketing</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-marketing-optout" data-category="cmplz_marketing" class="cmplz-consent-checkbox cmplz-marketing" size="40" value="1"/> <label class="cmplz-label" for="cmplz-marketing-optout" tabindex="0"><span class="screen-reader-text">Marketing</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary> <div class="cmplz-description"> <span class="cmplz-description-marketing">The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.</span> </div> </details> </div> </div> <div class="cmplz-links cmplz-information"> <a class="cmplz-link cmplz-manage-options cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">Manage options</a> <a class="cmplz-link cmplz-manage-third-parties cookie-statement" href="#" data-relative_url="#cmplz-cookies-overview">Manage services</a> <a class="cmplz-link cmplz-manage-vendors tcf cookie-statement" href="#" data-relative_url="#cmplz-tcf-wrapper">Manage {vendor_count} vendors</a> <a class="cmplz-link cmplz-external cmplz-read-more-purposes tcf" target="_blank" rel="noopener noreferrer nofollow" href="https://cookiedatabase.org/tcf/purposes/">Read more about these purposes</a> </div> <div class="cmplz-divider cmplz-footer"></div> <div class="cmplz-buttons"> <button class="cmplz-btn cmplz-accept">Accept</button> <button class="cmplz-btn cmplz-deny">Deny</button> <button class="cmplz-btn cmplz-view-preferences">View preferences</button> <button class="cmplz-btn cmplz-save-preferences">Save preferences</button> <a class="cmplz-btn cmplz-manage-options tcf cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">View preferences</a> </div> <div class="cmplz-links cmplz-documents"> <a class="cmplz-link cookie-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link privacy-statement" href="#" data-relative_url="">{title}</a> <a class="cmplz-link impressum" href="#" data-relative_url="">{title}</a> </div> </div> </div> <div id="cmplz-manage-consent" data-nosnippet="true"><button class="cmplz-btn cmplz-hidden cmplz-manage-consent manage-consent-1">Manage consent</button> <button class="cmplz-btn cmplz-hidden cmplz-manage-consent manage-consent-1">Manage consent</button> </div> <noscript><link rel='stylesheet' id='all-css-0d95eabe431ab683b076dc0f16745677' href='https://www.acdlabs.com/_jb_static/??-eJylzDEOwjAMheHbMNEaq4hOFWdpjSkWcRzFgYrbE4RgYqLbG97/wZIaslg4FkjhNkt0WMzIVDkTw+jOxYGCvB5TMLrWAzXv1ZL7Fn4Qcx7vUh5ny+pfwx1O4lUZXahVif/l5cLKNdFksUa+VhJGXGl88qMO2He473cH7DY0DfgET5iEhQ==' type='text/css' media='all' /></noscript><link rel='stylesheet' id='all-css-0d95eabe431ab683b076dc0f16745677' href='https://www.acdlabs.com/_jb_static/??-eJylzDEOwjAMheHbMNEaq4hOFWdpjSkWcRzFgYrbE4RgYqLbG97/wZIaslg4FkjhNkt0WMzIVDkTw+jOxYGCvB5TMLrWAzXv1ZL7Fn4Qcx7vUh5ny+pfwx1O4lUZXahVif/l5cLKNdFksUa+VhJGXGl88qMO2He473cH7DY0DfgET5iEhQ==' type='text/css' media="not all" data-media="all" onload="this.media=this.dataset.media; 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