CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "aacrjournals.org",cType: 'managed',cRay: '8e6e8779ce464637',cH: 'Zz3luTxz08dRaepPBrnKVDf0al_3dc2tJsak5aJY89Y-1732337330-1.2.1.1-cWMegQXs0ZvEBFdJi1LthQD5XMjskWdT8hIvHVS.Ojb94PM8nK40BGnQ3hP4a.YH',cUPMDTk: "\/bloodcancerdiscov\/article\/2\/5\/408\/665841\/Scalable-Manufacturing-of-CAR-T-Cells-for-Cancer?__cf_chl_tk=kwkxjxA._xWOb1oznK2chFtTtiqLKIIkTGY3fP4OV20-1732337330-1.0.1.1-PfuaDHnnKk2QPVyaskqGjNp.qWD.Tr7VB79OqSYjkqk",cFPWv: 'g',cITimeS: '1732337330',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/bloodcancerdiscov\/article\/2\/5\/408\/665841\/Scalable-Manufacturing-of-CAR-T-Cells-for-Cancer?__cf_chl_f_tk=kwkxjxA._xWOb1oznK2chFtTtiqLKIIkTGY3fP4OV20-1732337330-1.0.1.1-PfuaDHnnKk2QPVyaskqGjNp.qWD.Tr7VB79OqSYjkqk",md: "7WCQ2gKjY6Mx3BOo2FqRoCNph3XgikXCsmzsEFpJ26A-1732337330-1.2.1.1-0LsG5JAZ6j8kjd2Gv6Gp_T71cn69DireO8i_vHEQEZ3gbMl8LlDka0HitnRj2XEleNxyuqVawpTGPyQCQU29qrmTsVrQot2MvU1NN1vT.VWhCfnrTbGLi.rqvxuXZG3scYDVlJtU_j5lK0ZIozbLFhRNzYDS.wHFKN5VmGTzRH9mPhtchvR2MXPmugvdTyXPo_jJAUzufZq8egALt36eQmtctrHtm.GZPKYvkZR8uRvWIMY8pb_ldwUlwA1q8DkE2iQwTgBp.BWHMSYtmwYzASVttjXWwTDH12E8lVwwaheRJmZpcD8Z5lTrmT.Eq6lNaSQTnOO4CRS0fc4oE7CJbWxjuFNBbTdFqivwPNvyKKFCu2OmZsEoMSSwnbEoow_iow6xbffTEkpsEEFDt.8xtnYAosp2sMucfjdCJ17l.nkP.uEPwhejNOCMnVgzIO_0vff4ozdO.rR2hYzD2N0JrKFJ6R54R2ANrl1GKU7YDjxfohTG.dShyC3o7wO_Y10LxuYpHLLZzvvynC5xNBxLNZ70DrRvHW5H6AFdzqv4xPrzGRSjUGZyr2HngOlLhyKrO0F47MnBmHY_Ulv9KaO.BmuSrpmgz7pd21KzXY8UeDzaYbszKVoz65_Nk2OOjVr9Xs60ilJvnDRgpIvBRBKiflk50mKOuNfcwyI0dQsbGjtdZrFYHhwXnp2lVzI9TfAyx1QzWmpe.mKJ4SPMWMXKAfGJJ8zUBHK_bRQx2WkuSsY4tdGKUwraQGhqS0mtc7mhthkO2BUThkYP7N7FaoIk.rWutQyAui0NO.Y_9p6nle3JQZiLoy3O1leIa0PmYkwZLHZ4rTS47_lGRo4Vn2zaRFkqLFCeSovjW_uHuPLruf0_pqVF7gYPaG4A0aHmDSGHxwOXrsqBuuSh0yDR5s9x8nQPtEvv.h_JbPbOfA8cmKLv1Yy4CIiArk7O3IBrDmXfS9xrvCahVYCsv2Tts_oh_AM0sNgHL61Ppd6YfkoyF5lJYJu6P0MyqWoCC7TK9DW_1u.OeiITdWVv.OurDuM54Q5LhRPOGEifTa23Qyj28wYjkhKfIDv5XfSsdHkbkFkHz2jqDfbHaTbXM.CsbAbOROorhC_4l0nd.jMbqGlP7bIwncrRweskk2GjjoFfoY.WgK8ZPVSiao_jPSZbMw7JTLR8HqLJ4Jc3Tq7tiVEPGicHhGwxGUqwchOUWXWZ63RVpneDvtRS8TdgmB8krXTUsx0D0QLVyLn1BowfD46fPhGi1K4P6i0U_hdTejXPo7kfmTQffmjFpxqqz2hKjNasacYV34MjsEPm2qLz38wx2lLGF4MO9.BleDbvyu0ESY.hJAtmiyaXeyZnXocLqRrlHnebiv_BPjq2EAITCUxALDt1QTyB.sMQC9C.zQV1R425dNBjZ_KmVWOJvTUeQEPQcXk3o4BFRJp5qldoZehSEbHo2u6RBZP8PF4JsJghe3Z8zYaZwRQ5I9sqtlEltvUNB4JuGixsk1EEzjnX6Gy8jwBiQypBjUgyEPEIqYo1lXTJAw3spM7V1558d0xLzEfNMjr5lItJUICA9U953yUU9bELGRxlgLlxjyvblv.y3F8.dC_C9ga0HbCEAKxxpt40V8ko3bOFxDVj_B5dKunFZpTOXsvTkv6zw.owHvWn55WITmd.2aXvjdL2sYMJji0yaCal1_k1prtNLDhHysYGzDLoYrYO8SgDfnxbhO1JjPDpUGMHFmvngkPrGAwHdQ5LP7a7EaRbazYbmUVT56HdA9H7e83Rq55hFE2KqknuK7wHoVqbht8RCX2g.u66erh7M34h7qzOduJETmoC3iVjWT_Nbl6RvX632NvMPbTd1bmzOOtIZJVG0JAw026oToMRXlEE.woD53Bfa2oMEaEehmjxlydF6p8kjg2l.zYD18yqUCjjAzi9qkQqKBteYKuuwfWA6UB9jiO63cAlQ6bU8JaX.BrDVwqZ3Z7oglRHaV0eeRPLB4xcuWzF5HDBNtKH2CSAMWjfEnFGqD3DyV4syzAcXYOeKWEHp2T4mkpQq.gObc1GGreBjFAYbOrabBcXFX9rc7w9yBSLSQHXu0XlNrGfTuhy7VsLZjmcP3spsYpNwW_DmzxgMsW7aiYfRVLvZFczpvOta6Prwo26pY__bex5o9yeh3d.d3EhOEzaX2Y0lOEAIiQh7VtopoiYWtOdCkEXk94hdFW2ZAEeiJmwuoD20S7KJEE.oGH_.hoI64n.2EIuLZPA_BmLB_mdCETq5C8OHWE.T8uooEUGMBWq4qsZm88tex5etnbKqgupZykpAxS9Jb8EUAp5_jcR5k7zveL5J_tS3byccLNZHkJlHqMyTTRq1O0OGh1UUWOqIt2ln.uCHGD2L5cb1jMbFr53BdHFu1h8qfVcY7ykh_NNE1mJrI1oVepG9P6y.SwghDaI7_kLLupOeMwV0dcqHjrpoyKI0Ra_Fek8hVylZaNJUYuztw2toUy7U9J9GccMZVezWsSNwn_i9pedYBBYfGTL1tJ_8.bJqIDgjh6idbLb.VLdZelyhkjzgOW7fL.o76nxm7oLoTy6nUyeLB6pqzf8Lq89F9TlUZGAGI_2QTYwfoWA5vkmKNPWpeQclfwMWtNeZUVb2sK_Zc9CtdLoJm_Md7MBWf5OvbUbLOMmkx0ES8svFLWKWF9sw4DjZc.PQHUBFhoWkJ_e2hN5FiF5QN.pqJSJqsujagjr_uJYLDv_2eyw.PJaP9fkiJ54ypGq.S2tTJTrPTI6pmb0_PX8astf2NpM90g1Wac_QIm6ylYs3B0rYvo_zyx2Br26bUAqrslV3Bda6DUlQ3oKLTMxIZlW2RMeW24lPBHyOlQbB1XnL9_gynTRyCbzBmTYdJMW1d6JWbxVi..OVYB_0MZ.JUFgkMA.WMCvp.i79n6UAq81GUmENOwkw88doar8ulWHEDZPUWsZJLUNDJCGIFTAIUC51j8SRjGbjMosrajb8l65ZYhczIDtwfjk1EHqY4bj8aaSqRJpEAtbqY_HdZglf3b2q.Ugs_.XkEU4okl1tiZ8jjhDLP_J0gksu4_yOq.i4.Oi9ZrAiUc2QIbejVL5e1Zks2fpHg4ETLpUIFn4Qg.7Icg1qa6snRDOVlyp.PDD2e05lchScilUwXuh7W1fBCTfrA",mdrd: "1iLlJecLu8b2ahu2ZWtDBB2nPx6_S7nPHU3CG.wBkNk-1732337330-1.2.1.1-hQsfnwRQdZ9wQ.RQjIR9E_fj_hXSjbszCSuys5omLUH4L8..SwiLWdbgKp_wU5l84nhir1TeSj23Z5JotEMTdfQY9H6N2jQ9nu292k.oIyZldrijwBgXSRtqi0T12jpPJVN8PbZiZ0VE8_E5BIQoVdQzGEwAuBjLbst.LyNExECjZWsC8To5X2aGQOLXlWs9.6d04IWe2mc3mCv5XPubL0_zmuGjdWK_uG7OnZqx7.GVSnmaUdM92Wy2n_ixSAn7alpby7thEE5eKio68UwsD4vbZRsNaX60Z2jNaYTEphtCOmNGL_c9BBuZjrLaVz.vSTRzw74HbTtKnhlTWxwf2vyuZzPE4jXXzf8yLdzcgwuaKE3mKFOVXahwAnjHlttGjlLVMcmpNow.BwQTMB7NAtNz2OV9D.3vH4YSG97aWw_SdC8fHRDdEIoOLotz5UjUlyPkurFRDo9ho0y_6HlRpA.hwLf9QjHfESfWtrNtw_eDKmp4_fVIjGsNkm.oUfS0tMybGF0TplrK0Z0Rc8sHjXYE5ks7ZKVfViXUhI.6Im6aQrWvwPC7zTT939csxbgaEHaAxK3.TCyuuzWzK5h9rXh7djP6RVu2xdcHjdC73NvunHnqA3pLTE1QZOv9xEgzdH5v_r9uHmaEr7CfO.5zyER1uF2tPGNbz.A2hnBYeB.M5zFnfwkNQ6JjtA5EB1G89b4sc0k6tuT9xDljEWzq87EDAWdsxObZuwIj_h8Hwj_nKK1J9qEmzbBTl76SS6rmReSfLrZYa_igNSTU0_HKK3yz.zx.vOQqyzf2fl2eWoAGS2RV1WSHQAQvIAYrsbLceRlpKA.SnGEDOZgC3ybKAReQdqHE_FSI0NTDHpe9kQRKibgOsCMb58SiYidbSfmEyaYDVzq17eHv6tz7kFQgZnfUfRVwkAonhZv4Qxoh420L_WgQZ_Nnbf_gBg9RkH889fws5udhGu5BhCuIrHh2wJxTYbP8Zg0BX1zMDiTo5rI30Vl1qX5Et5BnBGBZWfiYwYZUXIxyFV_xjLe2ePw5x4xY9imL0Ewquhv4AUix6rKBpKEsshCtUn7mjRcuDh2r5WeLMJ1LbCqlxcBKOYavFoh0pE5vPNuphrYBU_FWUAQPyYr0645Uq5gjkD11ZEoWqC1l6Xdd96qAJzahkhdaKdEzdz4ONTvxAZ3eYmaPkCq_eAt7z9CC2077DBNcv8p4fW7ullXaQ05Y56f1fc9sXWmW7GmZQsCXQTQmMb7t47yz.0nB1t7aQfidhAN8rzv4YQLbX6BdBbB4.AmBLsE43ZcAwWi8GKheDPg70cGLv7v3C_c4lToHxAMjI028tpKHL.STPBMC829RKBfPQ0V1SpswA37_uSiaEr27ni5XGNrQU9XtUuKiMvNDf3nfOqqclmJg4aS.R54HrUpdFt2bn9sBl9ua2Obn636.HioC_7S8gxji85rV.OHzWablSZA27pV5BqmKqwl1NanG0UoH.ffRq_2Kh8fwbZRttHHgnvU_4xlrcgDOrpwt08dmXBzv5OCDeqc9l.Coypmh_8z1lBXRAH5hZR_TgrzgKKpIbygPEcH3oxG7w_D50c19LGIeDP46ad725BmoZ6ia6DwplysU0kZBpdFb6Mb_neAAQwRk8QWLvy9XNXs6fgCQrIP73gGep_c7jqdzyn7_n1UUz43xu2gR_ZEJ8Rncp2xCFLsFMDCip86yfbAJqxFYQap7fCvS0X4qB0ObGm3rdrHhPWx4huQXuoxdpNOB5SZeB7LZyxYh7bOAd5u08qUtAr5E5U17DNIAyyJAmKpPXRnXXFivKWrXYprU45LM8KFfDDUaRTJOeekaJPV.A2AGYLvHWn02YnqmgGvFMTsa4uJypQHAFK6tS8FBoAUdviPhVUOHUdyNZz8RiORs8ZQTXQjOjkIoPec5bkFrqNE4.RRyVVJi6cML8tRLHXCMkBG1WqsyGaZy49Zu2coLMECAcUlO"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e6e8779ce464637';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/bloodcancerdiscov\/article\/2\/5\/408\/665841\/Scalable-Manufacturing-of-CAR-T-Cells-for-Cancer?__cf_chl_rt_tk=kwkxjxA._xWOb1oznK2chFtTtiqLKIIkTGY3fP4OV20-1732337330-1.0.1.1-PfuaDHnnKk2QPVyaskqGjNp.qWD.Tr7VB79OqSYjkqk" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>