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class="content-sidebar-wrap"><main class="content"><article class="post-6999 post type-post status-publish format-standard has-post-thumbnail category-charged-aerosol-detection category-liquid-chromatography tag-charged-aerosol-detection tag-liquid-chromatography entry" aria-label="Which HPLC Detector Fits Your Analytes Best?"><header class="entry-header"><h1 class="entry-title">Which HPLC Detector Fits Your Analytes Best?</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/analyteguru/tf-author/jenny-wong/" title="Posts by Jenny Wong" rel="author">Jenny Wong, </a> </span> <span class="post-info-date"> 06.11.2021 </span> </header><div class="entry-content"><div class="lia-message-body-content"> <p>With so many HPLC detector options, how do you know which one is the right fit?</p> <p>An essential component of every chromatography instrument is the detector. You cannot see or measure the concentration of your analytes without one and using a detector incompatible with the target compound(s), like choosing a UV-Vis detector for analytes without chromophores, is a waste of your time and money.</p> <p>There are a lot of <a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors.html" target="_blank" rel="nofollow noopener">HPLC detector</a> options to consider – UV-Vis, fluorescence, charged aerosol detection mass spectrometry … the list goes on.</p> <p>Let’s look at how to choose the best detector for your application.</p> <h3 id="toc-hId--1902364086"><strong>Choosing an HPLC detector is a lot like buying shoes</strong></h3> <p><img decoding="async" class="alignright wp-image-11022" src="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog-300x200.jpg" alt="Image of shoes" width="398" height="265" srcset="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog-300x200.jpg 300w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog-1024x682.jpg 1024w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog-768x511.jpg 768w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog-96x65.jpg 96w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Image-1-Blog.jpg 1430w" sizes="(max-width: 398px) 100vw, 398px" /><br /> When I walk into a shoe store, I usually have in mind what type of activity I plan to do in those shoes. For example, I might want an everyday shoe that matches most outfits, a sturdy hiking boot for rough, uneven terrain, or a specialty shoe for tap dancing. Each of these shoes has a purpose, and some for multiple activities.</p> <p>Shoe buying isn’t that different than buying an HPLC detector. To understand which detector suits your work, you first should determine what type of analyte you want to detect and the relevant physiochemical properties of the compound.</p> <p>For example, if you are working with amino acids derivatized with a fluorescent tag, consider using a fluorescence detector. For those who like to avoid pre- or post-column derivatization, you would enjoy detection from a super versatile, universal <a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors/charged-aerosol-detectors.html" target="_blank" rel="nofollow noopener">charged aerosol detector (CAD)</a> (to get an idea of all the applications CAD is used for, <a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors/charged-aerosol-detectors.html" target="_blank" rel="nofollow noopener">check out this bibliography</a>).</p> <h3 id="toc-hId--1873734935"><strong>HPLC detector types</strong></h3> <p>Thermo Fisher Scientific offers a wide variety of detectors to cover all HPLC applications. This table will help you determine which HPLC detector you should consider based on an analyte’s physiochemical properties:</p> <p><img decoding="async" class="aligncenter size-full wp-image-11029" src="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest.jpg" alt="Table with detector type and related app notes " width="1698" height="1080" srcset="https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest.jpg 1698w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest-300x191.jpg 300w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest-1024x651.jpg 1024w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest-768x488.jpg 768w, https://www.thermofisher.com/blog/analyteguru/wp-content/uploads/sites/25/2023/06/061121-Table-The-very-latest-1536x977.jpg 1536w" sizes="(max-width: 1698px) 100vw, 1698px" /><strong><a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors.html#charged-aerosol-detectors" target="_blank" rel="nofollow noopener">More about the Charged Aerosol Detector (CAD)</a></strong></p> <p><strong><a href="https://www.youtube.com/watch?v=utseMBL1fTQ" target="_blank" rel="noopener nofollow noreferrer">Watch this video to get an overview of how CAD works</a></strong></p> <p><strong><a href="https://www.youtube.com/watch?v=OXzrCFDFD3c" target="_blank" rel="noopener nofollow noreferrer">Watch this video for an overview of how FLD works</a></strong></p> <p><strong><a href="https://www.youtube.com/watch?v=koLto8OsnVk" target="_blank" rel="noopener nofollow noreferrer">Watch this video for an overview of how MS works</a></strong></p> <h3 id="toc-hId--1845105784"><strong>Get started on the right foot by selecting the right HPLC detector for your application</strong></h3> <p>If you want more details on detectors you canlearn more about<a title="Read the related blog post" href="https://www.thermofisher.com/blog/analyteguru/detector-technologies-for-u-hplc/" target="_blank" rel="noopener nofollow noreferrer"> the pros and cons of HPLC detector technologies </a>in this short and informative blog post by Dr.Timothy Cross.</p> <p>I hope this chart helps your decision on which HPLC detector to use a little easier and less daunting than shopping for the perfect pair of shoes. Remember, the detector application is largely dependent on the structure of the analyte.</p> <p>Learn more about our <a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors.html#charged-aerosol-detectors" target="_blank" rel="nofollow noopener">HPLC detectors</a>, and check out our <a href="https://www.thermofisher.com/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-components/hplc-uhplc-detectors/selection.html" target="_blank" rel="nofollow noopener">HPLC detector selection guide</a> to find the right detector for you.</p> </div> </div></article><section class="author-box"><h4 class="author-box-title">Jenny Wong</h4><div class="author-box-content" itemprop="description"></div></section><div class="adjacent-entry-pagination pagination"><div class="pagination-previous alignleft"><i class="fa fa-icon fa-chevron-left"></i> <a href="https://www.thermofisher.com/blog/analyteguru/build-a-robust-charge-variant-method/" rel="prev">Protein Charge Variant Analysis: Crack the Code</a></div><div class="pagination-next alignright"><a href="https://www.thermofisher.com/blog/analyteguru/combining-hpae-with-orbitrap-ms-for-improved-glycoprotein/" rel="next">Combining HPAE with Orbitrap MS for Improved Glycoprotein Characterization</a> <i class="fa fa-icon fa-chevron-right"></i></div></div></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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