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However, a clear medical consensus concerning the clinical management of such healthy tissue sequelae does not exist. Our group has demonstrated in preclinical animal models that systemic mesenchymal stromal stem cells (MSCs) injection is a promising approach for the medical management of gastrointestinal disorder after irradiation. In a phase 1 clinical trial, we have shown that the clinical status of four first patients suffering from severe pelvic side effects (Epinal accident) was improved following MSC injection (figure). Two patients revealed a substantiated clinical response for pain and hemorrhage after MSC therapy. The frequency of painful diarrhea diminished from 6/d to 3/d after the first and 2/d after the 2nd MSC injection in one patient. A beginning fistulization process could be stopped in one patient resulting in a stable remission for more than 3 years of follow-up. A modulation of the lymphocyte subsets towards a regulatory pattern and diminution of activated T cells accompanies the clinical response. MSC therapy was effective on pain, diarrhea, hemorrhage, inflammation, fibrosis and limited fistulization. No toxicity was observed. We are now starting a clinical research protocol for patients with post-radiation abdominal and pelvic complications who have not seen their symptoms improve after conventional treatments (NCT02814864, Trial evaluating the efficacy of systemic MSC injections for the treatment of severe and chronic radiotherapy-induced abdomino-pelvic complications refractory to standard therapy (PRISME). It involves the participation of 6 radiotherapy services for the recruitment of 12 patients. 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class="wlcme_imdpub"> <div class="ft_top_content">  <h1 class="text-primary font-size-8 border-left-4 pl-2" style="border-left-color: #f35a36 !important;">Stem cell therapy in radiotherapy from bench to Clinical Trial Evaluating Efficacy of Mesenchymal Stromal Cell Injections for Treatment of Chronic Pelvic Complications Induced by Radiation Therapy</h1> <div style="background-color: #fefefe !important; padding: 10px !important;"> </div> <div style="padding:15px 0 !important;"><strong>Visit for more related articles at </strong><a href="https://www.imedpub.com/molecular-biology-and-biotechnology/archive.php" title="Journal of Molecular Biology and Biotechnology" class="btn btn-link">Journal of Molecular Biology and Biotechnology</a></div> <div> <h3 class="border-left-4 font-size-5 pl-2" style="border-left-color: #f35a36 !important;">Abstract</h3> </div> <div> <p>The late adverse effects of pelvic radiotherapy concern 5 to 10% of patients, which could be life threatening. However, a clear medical consensus concerning the clinical <a target='_blank' href='https://www.imedpub.com/scientific-journals-list/management-12126.html'>management</a> of such healthy tissue sequelae does not exist. Our group has demonstrated in preclinical animal models that systemic mesenchymal stromal stem <a target='_blank' href='https://www.imedpub.com/scientific-journals-list/cells-5822.html'>cells</a> (MSCs) injection is a promising approach for the medical <a target='_blank' href='https://www.imedpub.com/scientific-journals-list/management-12126.html'>management</a> of gastrointestinal disorder after irradiation. In a phase 1 clinical trial, we have shown that the clinical status of four first patients suffering from severe pelvic side effects (Epinal accident) was improved following MSC injection (figure). Two patients revealed a substantiated clinical response for pain and hemorrhage after MSC therapy. The frequency of painful diarrhea diminished from 6/d to 3/d after the first and 2/d after the 2nd MSC injection in one patient. A beginning fistulization process could be stopped in one patient resulting in a stable remission for more than 3 years of follow-up. A modulation of the lymphocyte subsets towards a regulatory pattern and diminution of activated T <a target='_blank' href='https://www.imedpub.com/scientific-journals-list/cells-5822.html'>cells</a> accompanies the clinical response. MSC therapy was effective on pain, diarrhea, hemorrhage, inflammation, fibrosis and limited fistulization. No toxicity was observed. We are now starting a clinical research protocol for patients with post-radiation abdominal and pelvic complications who have not seen their symptoms improve after conventional treatments (NCT02814864, Trial evaluating the efficacy of systemic MSC injections for the treatment of severe and chronic radiotherapy-induced abdomino-pelvic complications refractory to standard therapy (PRISME). It involves the participation of 6 radiotherapy services for the recruitment of 12 patients. They will all be treated and followed up in the hematology department of Saint Antoine Hospital.</p> </div> </div> <div class="ft_below_content"> </div> </div> </div>   <div class="col-lg-3 col-md-3">  <center> <img title="QR" src="https://chart.googleapis.com/chart?chs=185x185&cht=qr&chl=https%3A%2F%2Fwww.imedpub.com%2Farticles%2Fstem-cell-therapy-in-radiotherapy-from-bench-to-clinical-trial-evaluating--efficacy-of-mesenchymal-stromal-cell-injections-for--tr.php%3Faid%3D47967&chld=M|0&icqrf=00b1e4" />  <nav class="nav nav-pills social-icons-footer sidebar_social_icons a-pl-0" style="padding-left: 35px !important;"> <a title="Share This Article" target="_blank" class="nav-link" href="https://www.facebook.com/sharer.php?s=100&p[title]=Stem cell therapy in radiotherapy from bench to Clinical Trial Evaluating Efficacy of Mesenchymal Stromal Cell Injections for Treatment of Chronic Pelvic Complications Induced by Radiation Therapy&p[url]=https%3A%2F%2Fwww.imedpub.com%2Farticles%2Fstem-cell-therapy-in-radiotherapy-from-bench-to-clinical-trial-evaluating--efficacy-of-mesenchymal-stromal-cell-injections-for--tr.php%3Faid%3D47967"><img src="https://www.imedpub.com/assets/socials/facebook.png" /></a> <a title="Share This Article" target="_blank" class="nav-link" href="https://web.whatsapp.com/send?text=https%3A%2F%2Fwww.imedpub.com%2Farticles%2Fstem-cell-therapy-in-radiotherapy-from-bench-to-clinical-trial-evaluating--efficacy-of-mesenchymal-stromal-cell-injections-for--tr.php%3Faid%3D47967" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.imedpub.com/assets/socials/whatsapp.png" /></a> <a title="Share This Article" target="_blank" class="nav-link" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.imedpub.com%2Farticles%2Fstem-cell-therapy-in-radiotherapy-from-bench-to-clinical-trial-evaluating--efficacy-of-mesenchymal-stromal-cell-injections-for--tr.php%3Faid%3D47967" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.imedpub.com/assets/socials/linkedin.png" /></a> <a title="Share This Article" target="_blank" class="nav-link" href="https://twitter.com/share?text=Stem cell therapy in radiotherapy from bench to Clinical Trial Evaluating Efficacy of Mesenchymal Stromal Cell Injections for Treatment of Chronic Pelvic Complications Induced by Radiation Therapy&url=https%3A%2F%2Fwww.imedpub.com%2Farticles%2Fstem-cell-therapy-in-radiotherapy-from-bench-to-clinical-trial-evaluating--efficacy-of-mesenchymal-stromal-cell-injections-for--tr.php%3Faid%3D47967" class="nav-link"><img src="https://www.imedpub.com/assets/socials/twitter.png" /></a> </nav>  </center>  <div class="flyer_img"> Select your language of interest to view the total content in your interested language<br /> <div id="google_translate_element" align="center" style="width:180px;"></div> <script> function googleTranslateElementInit() { new google.translate.TranslateElement({ pageLanguage: 'en' }, 'google_translate_element'); 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