A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma - CityU Scholars

<!doctype html><html lang="en"><head> <meta charset="utf-8" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma - CityU Scholars | A Research Hub of Excellence</title> <meta property="og:image" content="/resources/style/gfx/logo_top.png" /> <meta property="og:url" content="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" /> <link rel="image_src" type="image/png" href="/resources/style/gfx/logo_top.png" /> <link rel="icon" href="/resources/style/gfx/favicon.ico" type="image/x-icon" /> <link href="https://fonts.googleapis.com/css?family=Open+Sans:400,300,700,600" rel="stylesheet" type="text/css" /><link type="text/css" rel="stylesheet" href="/resources/style/fonts/icons/css/fontello.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/js/slick/slick.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/js/slick/slick-theme.css?stamp=1731905518316" /><link type="text/css" rel="stylesheet" href="/resources/style/css/main.css?stamp=1731905518316" /> <link type="text/css" rel="stylesheet" href="https://www.cityu.edu.hk/scholars/portal/css/main_cu.css" /><script type="text/javascript" src="/dwr/engine.js?stamp=1731905518316"></script><script type="text/javascript" src="/dwr/interface/PureFacade.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/lib/prototype.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/atira.js?stamp=1731905518316"></script><script type="text/javascript" src="/resources/style/js/atira_chart.js?stamp=1731905518316"></script><script type="text/javascript" src="/dwr/interface/GraphFacade.js?stamp=1731905518316"></script> <script type="text/javascript">(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){(i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)})(window,document,'script','//www.google-analytics.com/analytics.js','ga');ga('create', 'UA-11187669-7', { 'cookieDomain': document.location.hostname });ga('set', 'anonymizeIp', true);ga('send', 'pageview');</script> <meta name="citation_title" content="A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study" /><meta name="citation_author" content="Jinsei Miyoshi" /><meta name="citation_author_institution" content="Baylor Scott & White Health " /><meta name="citation_author_institution" content="Tokushima University" /><meta name="citation_author_institution" content=" Kawashima Hospital" /><meta name="citation_author" content="Zhongxu Zhu" /><meta name="citation_author_institution" content="Department of Biomedical Sciences" /><meta name="citation_author_institution" content="Chinese University of Hong Kong" /><meta name="citation_author_institution" content="Prince of Wales Hospital" /><meta name="citation_author_email" content="zxzhu2-c@my.cityu.edu.hk" /><meta name="citation_author_orcid" content="0000-0003-2197-5563" /><meta name="citation_author" content="Aiping Luo" /><meta name="citation_author_institution" content="Chinese Academy of Medical Sciences & Peking Union Medical College" /><meta name="citation_author" content="Shusuke Toden" /><meta name="citation_author_institution" content="Baylor Scott & White Health " /><meta name="citation_author" content="Xuantong Zhou" /><meta name="citation_author_institution" content="Chinese Academy of Medical Sciences & Peking Union Medical College" /><meta name="citation_author" content="Daisuke Izumi" /><meta name="citation_author_institution" content="Kumamoto University" /><meta name="citation_author" content="Mitsuro Kanda" /><meta name="citation_author_institution" content="Nagoya University" /><meta name="citation_author" content="Tetsuji Takayama" /><meta name="citation_author_institution" content="Tokushima University" /><meta name="citation_author" content="Iqbal M. Parker" /><meta name="citation_author_institution" content="University of Cape Town" /><meta name="citation_author" content="Minjie Wang" /><meta name="citation_author_institution" content="Chinese Academy of Medical Sciences & Peking Union Medical College" /><meta name="citation_author" content="Feng Gao" /><meta name="citation_author_institution" content="Sun Yat-Sen University" /><meta name="citation_author_email" content="fenggao5-c@my.cityu.edu.hk" /><meta name="citation_author_orcid" content="0000-0002-0500-5527" /><meta name="citation_author" content="Ali H. Zaidi" /><meta name="citation_author_institution" content="Highmark Health" /><meta name="citation_author" content="Hideo Baba" /><meta name="citation_author_institution" content="Kumamoto University" /><meta name="citation_author" content="Yasuhiro Kodera" /><meta name="citation_author_institution" content="Nagoya University" /><meta name="citation_author" content="Yongping Cui" /><meta name="citation_author_institution" content="Shenzhen Bay Laboratory" /><meta name="citation_author_institution" content="Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center" /><meta name="citation_author" content="Xin Wang" /><meta name="citation_author_institution" content="Chinese University of Hong Kong" /><meta name="citation_author_institution" content="Prince of Wales Hospital" /><meta name="citation_author_email" content="xwang484@cityu.edu.hk" /><meta name="citation_author_orcid" content="0000-0002-5122-2418" /><meta name="citation_author" content="Zhihua Liu" /><meta name="citation_author_institution" content="Chinese Academy of Medical Sciences & Peking Union Medical College" /><meta name="citation_author" content="Ajay Goel" /><meta name="citation_author_institution" content="Baylor Scott & White Health " /><meta name="citation_author_institution" content="City of Hope National Med Center" /><meta name="citation_publication_date" content="2022" /><meta name="citation_online_date" content="2022/06/07" /><meta name="citation_pdf_url" content="https://scholars.cityu.edu.hk/files/104517931/s12943_022_01507_x.pdf" /><meta name="citation_online_date" content="2022/06/07" /><meta name="citation_doi" content="10.1186/s12943-022-01507-x" /><meta name="citation_language" content="English" /><meta name="citation_keywords" content="Cancer; Liquid biopsy; Biomarker; Esophageal squamous cell carcinoma; microRNA" /><meta name="citation_pmid" content="35148754" /><meta name="citation_journal_title" content="Molecular Cancer" /><meta 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class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Journal Publications and Reviews<span class="type_parent_sep"> › </span></span><span class="type_classification">RGC 21 - Publication in refereed journal</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> <div class="tabs-container"> <ul class="clear"> <li class="selected"><a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html"><span>Overview</span></a> </li> <li><a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074)/projects.html"><span>Projects</span></a> </li> </ul> </div> <div class="pub-full"> <div class="pub-top"> <div class="view-box scopus"> <span class="number">45</span> <span>Scopus Citations</span> </div> <div class="view-box viewall-scopus"> <a target="_blank" class="view_all_scopus_button" href="https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85124576620&origin=recordpage"> Scopus Metrics </a> </div> <div class="view-box almetric"> <script type="text/javascript" src="//d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <div class="altmetric-embed pure_altmetric_component" data-badge-type="2" data-badge-popover="left" data-hide-no-mentions="true" data-link-target="true" data-doi="10.1186/s12943-022-01507-x"></div> </div> <div class="graph_viewer"> <div class="graph"><a class="portal_graphviewer_button" href="javascript:void(0);" id="j_id-222676425_40f6ca2e"><span>View graph of relations</span></a> <script type="text/javascript"></script> <i class="icon-network"></i> </div> </div> <div class="addthis"> <div class="addthis_sharing_toolbox"></div> </div> </div> <div class="view-box"> <h2 class="subheader">Author(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_associatesauthorsclassifiedsummarizedlistportal rendering_contributiontojournal rendering_associatesauthorsclassifiedsummarizedlistportal rendering_contributiontojournal_associatesauthorsclassifiedsummarizedlistportal"><ul class="relations persons"><li><a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link person"><span>Zhongxu Zhu</span></a></li><li><a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/feng-gao(f572520b-3930-4331-814f-20f6c2e528d6).html" class="link person"><span>Feng Gao</span></a></li><li><a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/xin-wang(4bddd273-710d-49c5-8f73-2b2ec01c82ad).html" class="link person"><span>Xin Wang</span></a></li><li><a onclick="$(this).up('ul').next('ul').toggleClassName('common_hidden');return false;" href="#" class="all link"><span>And 15 others</span></a></li></ul><ul class="relations persons common_hidden associates_authors_full_list"><li class="external">Jinsei Miyoshi</li><li class="external">Aiping Luo</li><li class="external">Shusuke Toden</li><li class="external">Xuantong Zhou</li><li class="external">Daisuke Izumi</li><li class="external">Mitsuro Kanda</li><li class="external">Tetsuji Takayama</li><li class="external">Iqbal M. Parker</li><li class="external">Minjie Wang</li><li class="external">Ali H. Zaidi</li><li class="external">Hideo Baba</li><li class="external">Yasuhiro Kodera</li><li class="external">Yongping Cui</li><li class="external">Zhihua Liu</li><li class="external">Ajay Goel</li></ul></div> </div> <div class="view-box"> <h2 class="subheader">Related Research Unit(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_associatesorganisationsportal rendering_contributiontojournal rendering_associatesorganisationsportal rendering_contributiontojournal_associatesorganisationsportal"><ul class="relations organisations"><li class="a"><a rel="Organisation" href="https://scholars.cityu.edu.hk/en/organisations/department-of-biomedical-sciences(7f082170-95c7-47b9-b02b-8eaecd285c60).html" class="link"><span>Department of Biomedical Sciences</span></a></li></ul></div> </div> <div class="view-box"> <h2 class="subheader">Detail(s)</h2><div class="rendering rendering_researchoutput rendering_researchoutput_detailsportal rendering_contributiontojournal rendering_detailsportal rendering_contributiontojournal_detailsportal"><div class="article"><table class="properties"><tbody><tr class="language"><th scope="row">Original language</th><td>English</td></tr><tr><th scope="row">Article number</th><td>44</td></tr><tr><th scope="row">Journal / Publication</th><td><a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span>Molecular Cancer</span></a></td></tr><tr><th scope="row">Volume</th><td>21</td></tr><tr><th scope="row">Online published</th><td><span class="date">11 Feb 2022</span></td></tr><tr class="status"><th scope="row">Publication status</th><td><span class="prefix">Published - </span><span class="date">2022</span></td></tr></tbody></table></div></div> </div> <div class="view-box"> <h2 class="subheader">Link(s)</h2> <table class="properties pub-links"> <tr> <th>DOI</th> <td><div class="rendering rendering_researchoutput rendering_researchoutput_versioneddoiextensionportal rendering_contributiontojournal rendering_versioneddoiextensionportal rendering_contributiontojournal_versioneddoiextensionportal"><h2 class="subheader">DOI</h3><ul class="relations links digital_object_identifiers"><li class="embargo_date_ended available open "><a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1186/s12943-022-01507-x" class="link"><span>https://doi.org/10.1186/s12943-022-01507-x</span></a> <span class="common_icon_16" style="background-image: url('/resources/style/icons/type/openaccess16.png');"></span><p class="dimmed">Final Published version</p></li></ul></div> </td> </tr> <tr> <th></th> <td> <span class="sfx-button" title="Check@CityULib"> <a href="https://julac.hosted.exlibrisgroup.com/primo-explore/openurl?ctx_ver=Z39.88-2004&ctx_tim=2024-11-24T04%3A54%3A35HKT&ctx_enc=info%3Aofi%2FencUTF-8&url_ver=Z39.88-2004&url_ctx_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Actx&rft.genre=article&rft_val_fmt=info%3Aofi%2Fkev%3Afmt%3Ajournal&rfr_id=info%3Asid%2F%3Apure&rft.atitle=A%20microRNA-based%20liquid%20biopsy%20signature%20for%20the%20early%20detection%20of%20esophageal%20squamous%20cell%20carcinoma&rft_id=info%3Adoi%2F10.1186%2Fs12943-022-01507-x&rft.aulast=Miyoshi&rft.aufirst=Jinsei&rft.auinit=J&rft.date=2022&rft.volume=21&rft.issn=1476-4598&rft.jtitle=Molecular%20Cancer&institution=CUH_ALMA&vid=CUH" target="_blank"> Check@CityULib </a> </span> </td> </tr> <tr> <th>Attachment(s)</th> <td><div class="rendering rendering_researchoutput rendering_researchoutput_versioneddocumentextensionportal rendering_contributiontojournal rendering_versioneddocumentextensionportal rendering_contributiontojournal_versioneddocumentextensionportal"><div class="subheader documents">Documents</div><ul class="relations documents"><li class="available"><a onclick="if (this.href) {window.open(this.href)}; return false;" href="https://scholars.cityu.edu.hk/files/104517931/s12943_022_01507_x.pdf" class="link title"><span>94401716.pdf</span></a> <span class="common_icon_16" style="background-image: url('/resources/style/icons/type/openaccess16.png');"></span><p class="dimmed">Final Published version, 1.89 MB<span class="mimetype">, PDF</span></p></li></ul></div><div class="rendering rendering_keywordable rendering_keywordgroupcopyright rendering_keywordable_keywordgroupcopyright"><div class="publishercopyright"><span class="copy-header">Publisher's Copyright Statement</span><ul class="relations keywords"><li>This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/</li></ul></div></div> </td> </tr> <tr> <th>Link to Scopus</th> <td><a target="_blank" class="scopus-link-pub" href="https://www.scopus.com/record/display.uri?eid=2-s2.0-85124576620&origin=recordpage"> https://www.scopus.com/record/display.uri?eid=2-s2.0-85124576620&origin=recordpage </a></td> </tr> <tr class="permanent_link"> <th>Permanent Link</th> <td> <a href="https://scholars.cityu.edu.hk/en/publications/publication(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html">https://scholars.cityu.edu.hk/en/publications/publication(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html</a></td> </tr> </table> </div> <div class="view-box"> <h2 class="subheader">Abstract</h2><div class="rendering rendering_researchoutput rendering_researchoutput_customabstractportal rendering_contributiontojournal rendering_customabstractportal rendering_contributiontojournal_customabstractportal"><div class="textblock"><b>Background: </b>Currently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein, we established and evaluated a circulating microRNA (miRNA)-based signature for the early detection of ESCC using a systematic genome-wide miRNA expression profling analysis. <br /><br /><b>Methods: </b>We performed miRNA candidate discovery using three ESCC tissue miRNA datasets (<i>n </i>=108, 238, and 216) and the candidate miRNAs were confrmed in tissue specimens (<i>n </i>=64) by qRT-PCR. Using a serum training cohort (<i>n </i>=408), we conducted multivariate logistic regression analysis to develop an ESCC circulating miRNA signature and the signature was subsequently validated in two independent retrospective and two prospective cohorts. <br /><br /><b>Results: </b>We identifed eighteen initial miRNA candidates from three miRNA expression datasets (<i>n </i>=108, 238, and 216) and subsequently validated their expression in ESCC tissues. We thereafter confrmed the overexpression of 8 miRNAs (miR-103, miR-106b, miR-151, miR-17, miR-181a, miR-21, miR-25, and miR-93) in serum specimens. Using a serum training cohort, we developed a circulating miRNA signature (AUC:0.83 [95%CI:0.79–0.87]) and the diagnostic performance of the miRNA signature was confrmed in two independent validation cohorts (<i>n </i>=126, AUC:0.80 [95%CI:0.69–0.91]; and <i>n </i>=165, AUC:0.89 [95%CI:0.83–0.94]). Finally, we demonstrated the diagnostic performance of the 8-miRNA signature in two prospective cohorts (<i>n </i>=185, AUC:0.92, [95%CI:0.87–0.96]); and (<i>n </i>=188, AUC:0.93, [95%CI:0.88–0.97]). Importantly, the 8-miRNA signature was superior to current clinical serological markers in discriminating early stage ESCC patients from healthy controls (<i>p </i><0.001).<br /><b><br /></b><b>Conclusions: </b>We have developed a novel and robust circulating miRNA-based signature for early detection of ESCC, which was successfully validated in multiple retrospective and prospective multinational, multicenter cohorts.</div></div> </div> <div class="view-box"> <h2 class="subheader">Research Area(s)</h2><div class="rendering rendering_keywordable rendering_keywordgroupsexcludecopyright rendering_keywordable_keywordgroupsexcludecopyright"><div class="keywordcontainers"><ul class="relations keywords"><li>Cancer, Liquid biopsy, Biomarker, Esophageal squamous cell carcinoma, microRNA</li></ul></div><div class="sustainabledevelopmentgoals"><ul class="relations keywords"><li><strong><a href="https://scholars.cityu.edu.hk/en/publications/browse.html?uri=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fgood_health_and_well_being&logicalname=sustainabledevelopmentgoals" class="link"><span>SDG 3 - Good Health and Well-being</span></a></strong></li></ul></div></div> </div> <div class="publication_related_concepts"> <div class="view_preview_panel"><script type="text/javascript" src="/resources/style/js/concept_tooltip.js?stamp=1731905518316"></script> <div class="relationlist for_publication_fingerprints"> <h2 class="section for_publication_fingerprints subheader"> Fingerprint </h2> <p class="portal_inline_help">Publication fingerprints text</p> <div class="concept_listing" data-content-id="94401716" data-locale="en_GB"> <div class="concept-badge-wrapper"><a class="portal_link concept" href="https://scholars.cityu.edu.hk/en/concepts/refinement.html?conceptIds=195874593" title="detection in INIS has a weight of 100%"><span> <div class="canvas-wrap"> <canvas 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href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074)/fingerprints.html"><span>Full Fingerprint ›</span></a> </div> </div> </div> </div> <div class="view-box citations"> <h2 class="subheader">Citation Format(s)</h2> <div class="tabs-container citations clear"> <ul class="citations"> <li class="selected"><a href="#">Standard</a></li> <li><a href="#">Harvard</a></li> <li><a href="#">APA</a></li> <li><a href="#">Vancouver</a></li> <li><a href="#">Author</a></li> </ul> <div class="cite-export"> <span class="publication_export">[ <a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).ris?download=true"><span>RIS</span></a> ]</span> <span class="publication_export">[ <a class="portal_link" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).bibtex?download=true"><span>BibTeX</span></a> ]</span> </div> </div> <div class="citation-container"> <div class="view-box cite"><div class="rendering rendering_researchoutput rendering_researchoutput_standard rendering_contributiontojournal rendering_standard rendering_contributiontojournal_standard"><a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" class="link"><span><strong>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study.</strong></span></a> / Miyoshi, Jinsei<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link"><span>; Zhu, Zhongxu</span></a>; Luo, Aiping et al. <br />In: <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span>Molecular Cancer</span></a>, Vol. 21, 44, 2022.<p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Journal Publications and Reviews<span class="type_parent_sep"> › </span></span><span class="type_classification">RGC 21 - Publication in refereed journal</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_harvard rendering_contributiontojournal rendering_harvard rendering_contributiontojournal_harvard">Miyoshi, J<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link"><span>, Zhu, Z</span></a>, Luo, A, Toden, S, Zhou, X, Izumi, D, Kanda, M, Takayama, T, Parker, IM, Wang, M<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/feng-gao(f572520b-3930-4331-814f-20f6c2e528d6).html" class="link"><span>, Gao, F</span></a>, Zaidi, AH, Baba, H, Kodera, Y, Cui, Y<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/xin-wang(4bddd273-710d-49c5-8f73-2b2ec01c82ad).html" class="link"><span>, Wang, X</span></a>, Liu, Z & Goel, A 2022, '<a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" class="link harvard_title"><span>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study</span></a>', <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span><em>Molecular Cancer</em></span></a>, vol. 21, 44. <a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1186/s12943-022-01507-x" class="link"><span>https://doi.org/10.1186/s12943-022-01507-x</span></a></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_apa rendering_contributiontojournal rendering_apa rendering_contributiontojournal_apa">Miyoshi, J.<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link"><span>, Zhu, Z.</span></a>, Luo, A., Toden, S., Zhou, X., Izumi, D., Kanda, M., Takayama, T., Parker, I. M., Wang, M.<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/feng-gao(f572520b-3930-4331-814f-20f6c2e528d6).html" class="link"><span>, Gao, F.</span></a>, Zaidi, A. H., Baba, H., Kodera, Y., Cui, Y.<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/xin-wang(4bddd273-710d-49c5-8f73-2b2ec01c82ad).html" class="link"><span>, Wang, X.</span></a>, Liu, Z., & Goel, A. (2022). <a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" class="link"><span>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study</span></a>. <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span><em>Molecular Cancer</em></span></a>, <em>21</em>, Article 44. <a onclick="window.open(this.href, '_blank','noopener,noreferrer'); return false;" href="https://doi.org/10.1186/s12943-022-01507-x" class="link"><span>https://doi.org/10.1186/s12943-022-01507-x</span></a></div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_vancouver rendering_contributiontojournal rendering_vancouver rendering_contributiontojournal_vancouver">Miyoshi J<a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link"><span>, Zhu Z</span></a>, Luo A, Toden S, Zhou X, Izumi D et al. <span class="title"><a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" class="link"><span>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: <span class="subtitle">a retrospective, prospective and multicenter study</span></span></a></span>. <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span>Molecular Cancer</span></a>. 2022;21:44. Epub 2022 Feb 11. doi: 10.1186/s12943-022-01507-x</div> </div> <div class="view-box cite" style="display: none;"><div class="rendering rendering_researchoutput rendering_researchoutput_author rendering_contributiontojournal rendering_author rendering_contributiontojournal_author">Miyoshi, Jinsei <a rel="Person" href="https://scholars.cityu.edu.hk/en/persons/zhongxu-zhu(4a890abf-50de-4594-a298-5b3104900867).html" class="link"><span> ; Zhu, Zhongxu</span></a> ; Luo, Aiping et al. / <a rel="ContributionToJournal" href="https://scholars.cityu.edu.hk/en/publications/a-micrornabased-liquid-biopsy-signature-for-the-early-detection-of-esophageal-squamous-cell-carcinoma(f8fe1ef3-dd65-481e-b8e7-08d9603f9074).html" class="link"><span><strong>A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma : a retrospective, prospective and multicenter study</strong></span></a>. In: <a rel="Journal" href="https://scholars.cityu.edu.hk/en/journals/molecular-cancer(ff27faad-e86d-4dda-a27b-0f8c2a0c3142)/publications.html" class="link"><span>Molecular Cancer</span></a>. 2022 ; Vol. 21.</div> </div> </div> </div> <div class="view-box"> <h2 class="subheader">Download Statistics</h2> <div class="chart-wrapper"><div class="portal_chart" id="j_id55192815_58308cc5" style="height: 300px;"><div class="portal_chart_empty"><span>No data available</span></div><div class="portal_chart_loading"></div></div><script type="text/javascript"> try {(function() { new portal.ChartUtil.renderChart({'element':'j_id55192815_58308cc5','dataSource':'',contentId:null,'chart':{title:{text:''},description:{text:''},categoryLabels:[{identity:'6\/2022',label:'Jun \'22'},{identity:'7\/2022',label:'Jul \'22'},{identity:'8\/2022',label:'Aug \'22'},{identity:'9\/2022',label:'Sep \'22'},{identity:'10\/2022',label:'Oct \'22'},{identity:'11\/2022',label:'Nov \'22'},{identity:'12\/2022',label:'Dec \'22'},{identity:'1\/2023',label:'Jan \'23'},{identity:'2\/2023',label:'Feb \'23'},{identity:'3\/2023',label:'Mar \'23'},{identity:'4\/2023',label:'Apr \'23'},{identity:'5\/2023',label:'May \'23'},{identity:'6\/2023',label:'Jun \'23'},{identity:'7\/2023',label:'Jul \'23'},{identity:'8\/2023',label:'Aug \'23'},{identity:'9\/2023',label:'Sep \'23'},{identity:'10\/2023',label:'Oct \'23'},{identity:'11\/2023',label:'Nov \'23'},{identity:'12\/2023',label:'Dec \'23'},{identity:'1\/2024',label:'Jan \'24'},{identity:'2\/2024',label:'Feb \'24'},{identity:'3\/2024',label:'Mar \'24'},{identity:'4\/2024',label:'Apr \'24'},{identity:'5\/2024',label:'May \'24'},{identity:'6\/2024',label:'Jun \'24'},{identity:'7\/2024',label:'Jul \'24'},{identity:'8\/2024',label:'Aug \'24'},{identity:'9\/2024',label:'Sep \'24'},{identity:'10\/2024',label:'Oct \'24'},{identity:'11\/2024',label:'Nov \'24'}],dataSets:[{type:'column',legend:'94401716.pdf (73)',entries:[{identity:'6\/2022',value:3},{identity:'7\/2022',value:3},{identity:'8\/2022',value:3},{identity:'9\/2022',value:2},{identity:'10\/2022',value:3},{identity:'11\/2022',value:2},{identity:'12\/2022',value:2},{identity:'1\/2023',value:2},{identity:'2\/2023',value:1},{identity:'3\/2023',value:1},{identity:'4\/2023',value:4},{identity:'5\/2023',value:3},{identity:'6\/2023',value:0},{identity:'7\/2023',value:1},{identity:'8\/2023',value:1},{identity:'9\/2023',value:3},{identity:'10\/2023',value:2},{identity:'11\/2023',value:3},{identity:'12\/2023',value:2},{identity:'1\/2024',value:3},{identity:'2\/2024',value:5},{identity:'3\/2024',value:3},{identity:'4\/2024',value:2},{identity:'5\/2024',value:1},{identity:'6\/2024',value:4},{identity:'7\/2024',value:2},{identity:'8\/2024',value:6},{identity:'9\/2024',value:2},{identity:'10\/2024',value:1},{identity:'11\/2024',value:3}]}]},years:5,'includeCurrentYear':false,'categoryLabels':'years','chartDataSetType':'column','expandLegends':true,locales:['en_GB']}); })();} catch (e) {if (window['atira']) {atira.handleException(e);}} </script></div> </div> </div> </div> </div> <div class="footer"> <div class="wrapper"> <div class="cityu-scholar-footer-outbox"> <div class="cityu-scholar-footer-inbox"> <a href="https://www.cityu.edu.hk/cityu/privacy/index.htm" title="Footer Privacy Policy" target="_blank">Privacy Policy</a> | <a href="https://www.cityu.edu.hk/cityu/copyright/index.htm#copyright" title="Footer Copyright" target="_blank">Copyright</a> | <a href="https://www.cityu.edu.hk/cityu/disclaimer/index.htm#disclaimer" title="Footer Disclaimer" target="_blank">Disclaimer</a> | <a href="https://www.cityu.edu.hk/cityu/accessibility/" title="Footer Accessibility" target="_blank">Accessibility</a> | <a href="https://www.cityu.edu.hk/cityu/contactus/index.htm" title="Footer Contact Us" target="_blank">Contact Us</a><br /> © City University of Hong Kong. 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A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma - CityU Scholars | A Research Hub of Excellence