CINXE.COM

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field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> <hr/> <h2>Free Resources</h2> <p>Tocris is proud to offer free scientific posters and reviews, all written by experts in their fields. We also produce in-house product guides, which give an overview of how our products are used in many research areas including <a href='/cell-biology/stem-cells' title='Browse products for Stem Cell Research'>stem cells</a>, <a href='/research-area/neuroscience-research' title='Browse products for Neuroscience Research'>neuroscience</a> and <a href='/research-area/cancer-research' title='Browse products for Cancer Research products'>cancer</a>, among others. Please <a href='/literature' title='Download or request posters, product guides and scientific review'>request a free copy or download</a> the PDF today!</p> <img src='https://resources.tocris.com/images/literature/tocris-literature.jpg' alt='Browse Tocris literature'> <hr/> <h2>Supporting Scientists Since 1982</h2> <p>Tocris Biosciences’ catalog comprises over 4500 products covering research areas including <a href='/research-area/neuroscience-research' title='Browse products for Neuroscience Research'>neuroscience</a>, <a href='/research-area/cancer-research' title='Browse products for Cancer Research products'>cancer</a>, <a href='/research-area/endocrinology-research' title='Browse products for Endocrinology Research'>endocrinology</a>, <a href='/research-area/pain-and-inflammation-research' title='Browse products for Pain and Inflammation Research'> pain and inflammation</a>, <a href='/research-area/cardiovascular-system-research' title='Browse products for Cardiovascular Research'>cardiovascular</a>, <a href='/research-area/immunology-research' title='Browse products for Immunology Research'>immunology</a>, <a href='/research-area/respiratory-system-research' title='Browse products for Respiratory Research'> respiratory system</a>, <a href='/cell-biology/stem-cells' title='Browse products for Stem Cell Research'>stem cells</a> and <a href='/research-area/cell-and-gene-therapy' title='Browse products for Cell and Gene Therapy '>cell and gene therapy</a>.</p> <p>Tocris has a dedicated team of PhD qualified product managers who assess all the latest tools and technologies, adding around 400 products every year. View the latest ranges in our <a href='/product-type' title=' Browse products for New Technologies'>portfolio</a> .</p> <div class="text-center"> <a href="/product-type"><img src='https://resources.tocris.com/images/targets/new-technology-banner.jpg' style='max-width:100%; margin:20px 0 10px 0' alt='New technology platforms and product ranges at Tocris'></a> </div> <hr/> <h2>Featured Product Range: Janelia Fluor<sup>®</sup> Dyes</h2> <p><a href='/product-type/janelia-fluor-dyes' title=' Browse JF dyes'> Janelia Fluor<sup>®</sup> dyes</a> are innovative small molecule fluorophores, which are very bright and photostable and importantly, they are cell-permeable, enabling live-cell intracellular imaging. Janelia Fluor<sup>®</sup> dyes are supplied with a number of reactivity groups including as free acid, maleimide, tetrazine and NHS esters, allowing for easy conjugation to antibodies (<a href='/protocols/fluorescent-dye-conjugation' title='View fluorophore conjugation protocols'>protocols</a> available). The amine reactive versions are compatible with self-labeling tag systems. Janelia Fluor<sup>®</sup> dyes are suitable for use with both conventional imaging and super resolution microscopy (SRM) techniques, including dSTORM. In addition, photoactivatable derivatives have been developed that are applicable in PALM microscopy too. Our Janelia Fluor<sup>®</sup> range spans the color spectrum from the green/yellow <a href='/products/janelia-fluor-525-se_6296' title='View and buy JF 525'> Janelia Fluor<sup>®</sup> 525</a>, to the far red <a href=' /products/janelia-fluor-669-se_6420' title=''View and buy JF 525'>Janelia Fluor<sup>®</sup> 669</a>.</p> <p>We also offer <a href="https://www.novusbio.com/products/janelia-fluor" target="_blank">Janelia Fluor<sup>®</sup> conjugated antibodies and custom conjugation services</a> with our sister company Novus Biologicals. Multiplex experiments can be planned on our <a href='/resources/spectral-viewer' title='Design your experiments using spectra viewer'>spectra viewer</a>.</p> <img src="https://resources.tocris.com/images/products/6147-janelia-collection.jpg" alt="Application of Janelia Fluor® Dyes in Cardiac Tissue" class="img-fluid" style="max-width:100%"> <p><small>Application of Janelia Fluor<sup>®</sup> Dyes in Cardiac Tissue - Left - displaying the distribution of collagen VI in the interstitial space between muscle cells. Labeled with a primary ab against collagen VI and a secondary ab conjugated to JF549 (#6147). Scale: 50 μm. Middle - An adult pig heart tissue section, 10 μm thick, labeled with abs against SERCA2ATPase, displays sarcoplasmic reticulum. Top: super-resolution image (dSTORM), bottom: diffraction limited widefield image. Scale: 200 nm. Right - Cardiomyocyte stained against α-actinin, displaying its periodic structure localised at the ends of sarcomeres (Z-discs). (left) Widefield fluorescence of JF549 (right) dSTORM super-resolution image (right). Scale: 1 μm.</small></p> <p><small>All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Alex Clowsley and Anna Meletiou</small></p> </div></div></div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br 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