CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="DLCRYkjB09WREr1o1012/u55C+eEgREvjMlCgRwdr5EbUM5GMEwQ7YRSN1LCtWhaZuuyoFe0gyUrY6Dmo/hExQ==" /> <meta name="citation_title" content="Genetic analysis of function and dysfunction in the central nervous system" /> <meta name="citation_journal_title" content="Cold Spring Harbor Symposia on Quantitative Biology" /> <meta name="citation_author" content="Alcino Silva" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system" /> <meta name="twitter:title" content="Genetic analysis of function and dysfunction in the central nervous system" /> <meta name="twitter:description" content="Academia.edu is a platform for academics to share research papers." /> <meta name="twitter:image" content="https://0.academia-photos.com/14683764/13884070/14956876/s200_alcino.silva.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system" /> <meta property="og:title" content="Genetic analysis of function and dysfunction in the central nervous system" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Genetic analysis of function and dysfunction in the central nervous system" /> <meta property="article:author" content="https://ucla.academia.edu/AlcinoSilva" /> <meta name="description" content="Genetic analysis of function and dysfunction in the central nervous system" /> <title>(PDF) Genetic analysis of function and dysfunction in the central nervous system | Alcino Silva - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732457593000); window.Aedu.timeDifference = new Date().getTime() - 1732457593000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":null,"author":[{"@context":"https://schema.org","@type":"Person","name":"Alcino Silva"}],"contributor":[],"dateCreated":"2016-08-26","dateModified":"2016-08-26","datePublished":null,"headline":"Genetic analysis of function and dysfunction in the central nervous system","inLanguage":"en","keywords":["Transcription Factors","Memory","Humans","Animals","Neuronal Plasticity","Central Nervous System","Biochemistry and cell biology"],"locationCreated":null,"publication":"Cold Spring Harbor Symposia on Quantitative Biology","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"ucla"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "2989ab44aa72b2c2afed107749089bac7ad83dcc6663a1ac4a52db0d145133f5", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="6jXpZUgLzTN5FOGcVnS4j0Nr1bZ2AozV52+neL7HMQz91bZBMIYOC2xUa6ZDjKYry/ls8aU3Ht9AxUUfASLaWA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="7kcT80ZW3O8Tkk4i4ZP97IhyX3EUHm9h4GE9z/5nLO35p0zXPtsf1wbSxBj0a+NIAODmNscr/WtHy9+oQYLHuQ==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><a class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/login" rel="nofollow">Log In</a><a class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://medium.com/@academia">Blog</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-bf3d831cde46cd0e142f29f81a3fc4ce5ab45a404c10c12a480e83de68aff851.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 14683764; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F28034149%2FGenetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F28034149%2FGenetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":48341071,"identifier":"Attachment_48341071","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":28034149,"created_at":"2016-08-26T12:08:37.543-07:00","from_world_paper_id":156910310,"updated_at":"2021-01-12T10:42:34.024-08:00","_data":{"publication_name":"Cold Spring Harbor Symposia on Quantitative Biology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Genetic analysis of function and dysfunction in the central nervous system","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [14683764]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":48341071,"attachmentType":"pdf"}"><img alt="First page of “Genetic analysis of function and dysfunction in the central nervous system”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/48341071/mini_magick20190204-6486-1xavxl9.png?1549278671" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Genetic analysis of function and dysfunction in the central nervous system</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="14683764" href="https://ucla.academia.edu/AlcinoSilva"><img alt="Profile image of Alcino Silva" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/14683764/13884070/14956876/s65_alcino.silva.jpg" />Alcino Silva</a></div><p class="ds-work-card--detail ds2-5-body-sm">Cold Spring Harbor Symposia on Quantitative Biology</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":48341071,"attachmentType":"pdf","workUrl":"https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":48341071,"attachmentType":"pdf","workUrl":"https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="48341071" data-landing_url="https://www.academia.edu/28034149/Genetic_analysis_of_function_and_dysfunction_in_the_central_nervous_system" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="6308824" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6308824/The_hippocampus_A_biological_model_for_studying_learning_and_memory">The hippocampus: A biological model for studying learning and memory</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9798777" href="https://utica.academia.edu/stevenspecht">steven specht</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Progress in Neurobiology, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The hippocampus: A biological model for studying learning and memory","attachmentId":48922219,"attachmentType":"pdf","work_url":"https://www.academia.edu/6308824/The_hippocampus_A_biological_model_for_studying_learning_and_memory","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/6308824/The_hippocampus_A_biological_model_for_studying_learning_and_memory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="116200766" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116200766/Introductory_Chapter_A_Brief_Survey_of_the_Functional_Roles_of_the_Hippocampus">Introductory Chapter: A Brief Survey of the Functional Roles of the Hippocampus</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="202642187" href="https://independent.academia.edu/DouglasBurman">Douglas Burman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IntechOpen eBooks, 2023</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Introductory Chapter: A Brief Survey of the Functional Roles of the Hippocampus","attachmentId":112397395,"attachmentType":"pdf","work_url":"https://www.academia.edu/116200766/Introductory_Chapter_A_Brief_Survey_of_the_Functional_Roles_of_the_Hippocampus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/116200766/Introductory_Chapter_A_Brief_Survey_of_the_Functional_Roles_of_the_Hippocampus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="37198711" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37198711/Role_of_the_hippocampus_in_memory_functioning_modern_view">Role of the hippocampus in memory functioning: modern view</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41036234" href="https://bogomoletsnationalmedical.academia.edu/DmytroAssonov">Dmytro Assonov</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The purpose of this review was to develop the comprehensive conception of the hippocampus role in the functioning of human memory, based on data obtained by analysis of the latest scientific literature on the topic and develop recommendations for further ways of researches in this topic. The scientific literature of the last 5 years on the role of the hippocampus in memory functioning was analyzed. Based on the proceed literature, we made the next conclusions: 1.) the hippocampus is an unusually important for memory structure with connections, different for different types of memory; 2.) The hippocampus is affected by a variety of substances, most studied now are glucocorticosteroids, whose effect on memory differs depending on the time of onset of action. 3.) The volume of the hippocampus in mental disorders affecting memory is less than normal, which makes it an important diagnostic criterion; 4.) At the moment, various promising methods that can help in the therapy of PTSD, depression, phobias and other disorders associated with memory impairment and based on the knowledge of the hippocampus for the treatment of memory disorders are being developed. Based on these conclusions and data, which was analyzed, we offered the following recommendations: 1.) to implement an examination of the hippocampal function in the tactics of diagnosing mental disorders, which may be accompanied by a violation of his work; 2.) To use the size of the hippocampus as one of the prognostic factors for the severity of the memory-associated disorders and the progress of therapy; 3.) to carefully investigate the difference in the effect of various psychotherapies and pharmacotherapies on the hippocampus to say exactly which of the therapies is the most morphologically reasonable; 4.) to find out how significant the decrease in the hippocampal volume is for the functioning of memory; 5.) to use pathogenetically and morphologically based methods to improve the function of the hippocampus in the treatment of disorders that are accompanied by memory problems.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of the hippocampus in memory functioning: modern view","attachmentId":57149598,"attachmentType":"pdf","work_url":"https://www.academia.edu/37198711/Role_of_the_hippocampus_in_memory_functioning_modern_view","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37198711/Role_of_the_hippocampus_in_memory_functioning_modern_view"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="117156014" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117156014/Recent_advances_in_hippocampal_structure_and_function">Recent advances in hippocampal structure and function</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34371713" href="https://independent.academia.edu/JonStormmathisen">Jon Storm-mathisen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell and Tissue Research, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Recent advances in hippocampal structure and function","attachmentId":113087646,"attachmentType":"pdf","work_url":"https://www.academia.edu/117156014/Recent_advances_in_hippocampal_structure_and_function","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/117156014/Recent_advances_in_hippocampal_structure_and_function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="35263022" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/35263022/Psychobiological_Models_of_Hippocampal_Function_in_Learning_and_Memory">Psychobiological Models of Hippocampal Function in Learning and Memory</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51043762" href="https://independent.academia.edu/CatherineMyers1">Catherine Myers</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annual Review of Psychology, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Psychobiological Models of Hippocampal Function in Learning and Memory","attachmentId":55123355,"attachmentType":"pdf","work_url":"https://www.academia.edu/35263022/Psychobiological_Models_of_Hippocampal_Function_in_Learning_and_Memory","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/35263022/Psychobiological_Models_of_Hippocampal_Function_in_Learning_and_Memory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="28130639" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28130639/The_connection_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain_A_review_of_recent_findings">The connection between the hippocampal and the striatal memory systems of the brain: A review of recent findings</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47207691" href="https://independent.academia.edu/JorgeMedina109">Jorge Medina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurotoxicity Research, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The connection between the hippocampal and the striatal memory systems of the brain: A review of recent findings","attachmentId":48445306,"attachmentType":"pdf","work_url":"https://www.academia.edu/28130639/The_connection_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain_A_review_of_recent_findings","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/28130639/The_connection_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain_A_review_of_recent_findings"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="44663484" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/44663484/The_Hippocampus_Plasticity_and_Functions_Edited_by_Ales_Stuchlik">The Hippocampus Plasticity and Functions Edited by Ales Stuchlik</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16579512" href="https://cas-cz.academia.edu/AlesStuchlik">Ales Stuchlik</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Hippocampus Plasticity and Functions Edited by Ales Stuchlik","attachmentId":65135939,"attachmentType":"pdf","work_url":"https://www.academia.edu/44663484/The_Hippocampus_Plasticity_and_Functions_Edited_by_Ales_Stuchlik","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/44663484/The_Hippocampus_Plasticity_and_Functions_Edited_by_Ales_Stuchlik"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="56994570" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56994570/The_role_of_the_hippocampus_in_mnemonic_integration_and_retrieval_complementary_evidence_from_lesion_and_inactivation_studies">The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33301277" href="https://cardiff.academia.edu/JohnAggleton">John Aggleton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Neuroscience, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies","attachmentId":72108251,"attachmentType":"pdf","work_url":"https://www.academia.edu/56994570/The_role_of_the_hippocampus_in_mnemonic_integration_and_retrieval_complementary_evidence_from_lesion_and_inactivation_studies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56994570/The_role_of_the_hippocampus_in_mnemonic_integration_and_retrieval_complementary_evidence_from_lesion_and_inactivation_studies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="19609801" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19609801/Specific_responses_of_human_hippocampal_neurons_are_associated_with_better_memory">Specific responses of human hippocampal neurons are associated with better memory</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33380363" href="https://ucla.academia.edu/BarbaraKnowlton">Barbara Knowlton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National Academy of Sciences of the United States of America, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">A population of human hippocampal neurons has shown responses to individual concepts (e.g., Jennifer Aniston) that generalize to different instances of the concept. However, recordings from the rodent hippocampus suggest an important function of these neurons is their ability to discriminate overlapping representations, or pattern separate, a process that may facilitate discrimination of similar events for successful memory. In the current study, we explored whether human hippocampal neurons can also demonstrate the ability to discriminate between overlapping representations and whether this selectivity could be directly related to memory performance. We show that among medial temporal lobe (MTL) neurons, certain populations of neurons are selective for a previously studied (target) image in that they show a significant decrease in firing rate to very similar (lure) images. We found that a greater proportion of these neurons can be found in the hippocampus compared with other MTL re...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Specific responses of human hippocampal neurons are associated with better memory","attachmentId":42072644,"attachmentType":"pdf","work_url":"https://www.academia.edu/19609801/Specific_responses_of_human_hippocampal_neurons_are_associated_with_better_memory","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19609801/Specific_responses_of_human_hippocampal_neurons_are_associated_with_better_memory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="59590694" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/59590694/Hippocampal_Role_in_Cognitive_Functions_and_Memory_and_Effects_of_a_Novel_Cognitive_Enhancer_on_Learning_Deficits_Due_to_Hippocampal_Lesions">Hippocampal Role in Cognitive Functions and Memory, and Effects of a Novel Cognitive Enhancer on Learning Deficits Due to Hippocampal Lesions</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="11649342" href="https://independent.academia.edu/HisaoNishijo">Hisao Nishijo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Psychogeriatrics, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hippocampal Role in Cognitive Functions and Memory, and Effects of a Novel Cognitive Enhancer on Learning Deficits Due to Hippocampal Lesions","attachmentId":73435875,"attachmentType":"pdf","work_url":"https://www.academia.edu/59590694/Hippocampal_Role_in_Cognitive_Functions_and_Memory_and_Effects_of_a_Novel_Cognitive_Enhancer_on_Learning_Deficits_Due_to_Hippocampal_Lesions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59590694/Hippocampal_Role_in_Cognitive_Functions_and_Memory_and_Effects_of_a_Novel_Cognitive_Enhancer_on_Learning_Deficits_Due_to_Hippocampal_Lesions"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":48341071,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":48341071,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_48341071" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="15584414" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15584414/Dissociable_effects_of_selective_lesions_to_hippocampal_subsystems_on_exploratory_behavior_contextual_learning_and_spatial_learning">Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34750068" href="https://independent.academia.edu/GoodMark">Mark Good</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Behavioral Neuroscience, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning","attachmentId":43061537,"attachmentType":"pdf","work_url":"https://www.academia.edu/15584414/Dissociable_effects_of_selective_lesions_to_hippocampal_subsystems_on_exploratory_behavior_contextual_learning_and_spatial_learning","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15584414/Dissociable_effects_of_selective_lesions_to_hippocampal_subsystems_on_exploratory_behavior_contextual_learning_and_spatial_learning"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="13742477" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13742477/Selective_Hippocampal_Lesions_in_Rats_Disrupt_Acquisition_and_Retention_of_a_Positive_Patterning_Discrimination">Selective Hippocampal Lesions in Rats Disrupt Acquisition and Retention of a Positive Patterning Discrimination</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32862612" href="https://independent.academia.edu/NicoleMassioui">Nicole Massioui</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33001247" href="https://independent.academia.edu/PGisquetverrier">P. Gisquet-verrier</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Physiology & Behavior, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Selective Hippocampal Lesions in Rats Disrupt Acquisition and Retention of a Positive Patterning Discrimination","attachmentId":45001208,"attachmentType":"pdf","work_url":"https://www.academia.edu/13742477/Selective_Hippocampal_Lesions_in_Rats_Disrupt_Acquisition_and_Retention_of_a_Positive_Patterning_Discrimination","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13742477/Selective_Hippocampal_Lesions_in_Rats_Disrupt_Acquisition_and_Retention_of_a_Positive_Patterning_Discrimination"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="4357223" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4357223/Dynamic_interplays_between_memory_systems_depend_on_practice_The_hippocampus_is_not_always_the_first_to_provide_solution">Dynamic interplays between memory systems depend on practice: The hippocampus is not always the first to provide solution</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5322107" href="https://u-bordeaux1.academia.edu/NicoleMons">Nicole Mons</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neuroscience, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dynamic interplays between memory systems depend on practice: The hippocampus is not always the first to provide solution","attachmentId":49917219,"attachmentType":"pdf","work_url":"https://www.academia.edu/4357223/Dynamic_interplays_between_memory_systems_depend_on_practice_The_hippocampus_is_not_always_the_first_to_provide_solution","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/4357223/Dynamic_interplays_between_memory_systems_depend_on_practice_The_hippocampus_is_not_always_the_first_to_provide_solution"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="99182989" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99182989/Selective_hippocampal_lesions_in_rats_do_not_affect_retrieval_processes_promoted_by_prior_cuing_with_the_conditioned_stimulus_or_the_context">Selective hippocampal lesions in rats do not affect retrieval processes promoted by prior cuing with the conditioned stimulus or the context</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="73652216" href="https://independent.academia.edu/FrancoiseSchenk">Francoise Schenk</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Psychobiology, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Selective hippocampal lesions in rats do not affect retrieval processes promoted by prior cuing with the conditioned stimulus or the context","attachmentId":100338202,"attachmentType":"pdf","work_url":"https://www.academia.edu/99182989/Selective_hippocampal_lesions_in_rats_do_not_affect_retrieval_processes_promoted_by_prior_cuing_with_the_conditioned_stimulus_or_the_context","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/99182989/Selective_hippocampal_lesions_in_rats_do_not_affect_retrieval_processes_promoted_by_prior_cuing_with_the_conditioned_stimulus_or_the_context"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="17863574" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17863574/Memory_Visual_Discrimination_Performance_and_the_Human_Hippocampus">Memory, Visual Discrimination Performance, and the Human Hippocampus</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37776500" href="https://independent.academia.edu/AnnaVanDerHorst">Anna Van Der Horst</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neuroscience, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Memory, Visual Discrimination Performance, and the Human Hippocampus","attachmentId":39750733,"attachmentType":"pdf","work_url":"https://www.academia.edu/17863574/Memory_Visual_Discrimination_Performance_and_the_Human_Hippocampus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17863574/Memory_Visual_Discrimination_Performance_and_the_Human_Hippocampus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="4175976" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4175976/Behavioral_tests_of_hippocampal_function_simple_paradigms_complex_problems">Behavioral tests of hippocampal function- simple paradigms complex problems</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5050629" href="https://udd.academia.edu/CRuiz">Carolina Ruiz</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Behavioral tests of hippocampal function- simple paradigms complex problems","attachmentId":31677935,"attachmentType":"pdf","work_url":"https://www.academia.edu/4175976/Behavioral_tests_of_hippocampal_function_simple_paradigms_complex_problems","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/4175976/Behavioral_tests_of_hippocampal_function_simple_paradigms_complex_problems"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="20894849" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20894849/The_effect_of_excitotoxic_hippocampal_lesions_on_simple_and_conditional_discrimination_learning_in_the_rat">The effect of excitotoxic hippocampal lesions on simple and conditional discrimination learning in the rat</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38121460" href="https://cambridge.academia.edu/RosalindRidley">Rosalind Ridley</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Behavioural Brain Research, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The effect of excitotoxic hippocampal lesions on simple and conditional discrimination learning in the rat","attachmentId":41617607,"attachmentType":"pdf","work_url":"https://www.academia.edu/20894849/The_effect_of_excitotoxic_hippocampal_lesions_on_simple_and_conditional_discrimination_learning_in_the_rat","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/20894849/The_effect_of_excitotoxic_hippocampal_lesions_on_simple_and_conditional_discrimination_learning_in_the_rat"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="28130507" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28130507/The_evidence_for_hippocampal_long_term_potentiation_as_a_basis_of_memory_for_simple_tasks">The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47207691" href="https://independent.academia.edu/JorgeMedina109">Jorge Medina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Anais da Academia Brasileira de Ciências, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks","attachmentId":48445226,"attachmentType":"pdf","work_url":"https://www.academia.edu/28130507/The_evidence_for_hippocampal_long_term_potentiation_as_a_basis_of_memory_for_simple_tasks","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/28130507/The_evidence_for_hippocampal_long_term_potentiation_as_a_basis_of_memory_for_simple_tasks"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="79514381" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79514381/Role_of_the_hippocampus_in_configural_learning">Role of the hippocampus in configural learning</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="220719090" href="https://independent.academia.edu/BurnettDean">Dean Burnett</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of the hippocampus in configural learning","attachmentId":86203519,"attachmentType":"pdf","work_url":"https://www.academia.edu/79514381/Role_of_the_hippocampus_in_configural_learning","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/79514381/Role_of_the_hippocampus_in_configural_learning"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="84836751" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84836751/Hippocampal_lesions_produce_a_temporally_graded_retrograde_amnesia_on_a_dry_version_of_the_Morris_swimming_task">Hippocampal lesions produce a temporally graded retrograde amnesia on a dry version of the Morris swimming task</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8332817" href="https://downstate.academia.edu/JohnKubie">John Kubie</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Psychobiology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hippocampal lesions produce a temporally graded retrograde amnesia on a dry version of the Morris swimming task","attachmentId":89725393,"attachmentType":"pdf","work_url":"https://www.academia.edu/84836751/Hippocampal_lesions_produce_a_temporally_graded_retrograde_amnesia_on_a_dry_version_of_the_Morris_swimming_task","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/84836751/Hippocampal_lesions_produce_a_temporally_graded_retrograde_amnesia_on_a_dry_version_of_the_Morris_swimming_task"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="16764328" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16764328/Memory_function_and_the_hippocampus">Memory function and the hippocampus</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33544653" href="https://surrey.academia.edu/BertramOpitz">Bertram Opitz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers of neurology and neuroscience, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Memory function and the hippocampus","attachmentId":39170565,"attachmentType":"pdf","work_url":"https://www.academia.edu/16764328/Memory_function_and_the_hippocampus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/16764328/Memory_function_and_the_hippocampus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="14212263" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14212263/A_computational_theory_of_hippocampal_function_and_empirical_tests_of_the_theory">A computational theory of hippocampal function, and empirical tests of the theory</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33197596" href="https://utah.academia.edu/RaymondKesner">Raymond Kesner</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Progress in Neurobiology, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A computational theory of hippocampal function, and empirical tests of the theory","attachmentId":44460007,"attachmentType":"pdf","work_url":"https://www.academia.edu/14212263/A_computational_theory_of_hippocampal_function_and_empirical_tests_of_the_theory","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14212263/A_computational_theory_of_hippocampal_function_and_empirical_tests_of_the_theory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="23381568" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23381568/A_simple_test_of_the_vicarious_trial_and_error_hypothesis_of_hippocampal_function">A simple test of the vicarious trial-and-error hypothesis of hippocampal function</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39300939" href="https://independent.academia.edu/DanHu9">Dan Hu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National Academy of Sciences, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A simple test of the vicarious trial-and-error hypothesis of hippocampal function","attachmentId":43831413,"attachmentType":"pdf","work_url":"https://www.academia.edu/23381568/A_simple_test_of_the_vicarious_trial_and_error_hypothesis_of_hippocampal_function","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/23381568/A_simple_test_of_the_vicarious_trial_and_error_hypothesis_of_hippocampal_function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="61005611" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61005611/Considerations_arising_from_a_complementary_learning_systems_perspective_on_hippocampus_and_neocortex">Considerations arising from a complementary learning systems perspective on hippocampus and neocortex</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="73046652" href="https://independent.academia.edu/NigelGoddard">Nigel Goddard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hippocampus, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Considerations arising from a complementary learning systems perspective on hippocampus and neocortex","attachmentId":74200876,"attachmentType":"pdf","work_url":"https://www.academia.edu/61005611/Considerations_arising_from_a_complementary_learning_systems_perspective_on_hippocampus_and_neocortex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/61005611/Considerations_arising_from_a_complementary_learning_systems_perspective_on_hippocampus_and_neocortex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="16577216" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16577216/Two_case_studies_illustrating_how_relatively_selective_hippocampal_lesions_in_humans_can_have_quite_different_effects_on_memory">Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35888866" href="https://independent.academia.edu/SimonFleminger">Simon Fleminger</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50129303" href="https://independent.academia.edu/AbrahamsSharon">Sharon Abrahams</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hippocampus, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory","attachmentId":42432153,"attachmentType":"pdf","work_url":"https://www.academia.edu/16577216/Two_case_studies_illustrating_how_relatively_selective_hippocampal_lesions_in_humans_can_have_quite_different_effects_on_memory","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/16577216/Two_case_studies_illustrating_how_relatively_selective_hippocampal_lesions_in_humans_can_have_quite_different_effects_on_memory"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="116192548" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116192548/Mnemonic_theories_of_hippocampal_function">Mnemonic theories of hippocampal function</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52178759" href="https://hms-harvard.academia.edu/CynthiaWible">Cynthia Wible</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Behavioral Neuroscience, 1986</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mnemonic theories of hippocampal function","attachmentId":112391334,"attachmentType":"pdf","work_url":"https://www.academia.edu/116192548/Mnemonic_theories_of_hippocampal_function","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/116192548/Mnemonic_theories_of_hippocampal_function"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="28130508" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/28130508/A_link_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain">A link between the hippocampal and the striatal memory systems of the brain</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47207691" href="https://independent.academia.edu/JorgeMedina109">Jorge Medina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Anais da Academia Brasileira de Ciências, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A link between the hippocampal and the striatal memory systems of the brain","attachmentId":48445219,"attachmentType":"pdf","work_url":"https://www.academia.edu/28130508/A_link_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/28130508/A_link_between_the_hippocampal_and_the_striatal_memory_systems_of_the_brain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="17" data-entity-id="1152319" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/1152319/Hippocampal_and_neocortical_contributions_to_memory_Advances_in_the_complementary_learning_systems_framework">Hippocampal and neocortical contributions to memory: Advances in the complementary learning systems framework</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1039829" href="https://colorado.academia.edu/RandallOReilly">Randall O'Reilly</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Trends in Cognitive Sciences, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hippocampal and neocortical contributions to memory: Advances in the complementary learning systems framework","attachmentId":51083460,"attachmentType":"pdf","work_url":"https://www.academia.edu/1152319/Hippocampal_and_neocortical_contributions_to_memory_Advances_in_the_complementary_learning_systems_framework","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/1152319/Hippocampal_and_neocortical_contributions_to_memory_Advances_in_the_complementary_learning_systems_framework"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="18" data-entity-id="19387848" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19387848/The_hippocampus_supports_multiple_cognitive_processes_through_relational_binding_and_comparison">The hippocampus supports multiple cognitive processes through relational binding and comparison</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39653825" href="https://independent.academia.edu/RosannaOlsen">Rosanna Olsen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in human neuroscience, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The hippocampus supports multiple cognitive processes through relational binding and comparison","attachmentId":40592233,"attachmentType":"pdf","work_url":"https://www.academia.edu/19387848/The_hippocampus_supports_multiple_cognitive_processes_through_relational_binding_and_comparison","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/19387848/The_hippocampus_supports_multiple_cognitive_processes_through_relational_binding_and_comparison"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="83652539" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83652539/Hippocampal_Modulation_of_Associative_Learning">Hippocampal Modulation of Associative Learning</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58946059" href="https://independent.academia.edu/ZafraLerman">Zafra Lerman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1992</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hippocampal Modulation of Associative Learning","attachmentId":88927077,"attachmentType":"pdf","work_url":"https://www.academia.edu/83652539/Hippocampal_Modulation_of_Associative_Learning","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/83652539/Hippocampal_Modulation_of_Associative_Learning"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="20" data-entity-id="69033998" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/69033998/Working_memory_theory_of_hippocampal_function_needs_qualification">Working memory theory of hippocampal function needs qualification</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44300692" href="https://independent.academia.edu/VivianePallage">Viviane Pallage</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Behavioral and neural biology, 1984</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Working memory theory of hippocampal function needs qualification","attachmentId":79288000,"attachmentType":"pdf","work_url":"https://www.academia.edu/69033998/Working_memory_theory_of_hippocampal_function_needs_qualification","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/69033998/Working_memory_theory_of_hippocampal_function_needs_qualification"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="21" data-entity-id="61888336" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61888336/Tracking_the_Course_of_Hippocampal_Representations_during_Learning_When_Is_the_Map_Required">Tracking the Course of Hippocampal Representations during Learning: When Is the Map Required?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="156237288" href="https://independent.academia.edu/porl3141">Peter Lipa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neuroscience, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tracking the Course of Hippocampal Representations during Learning: When Is the Map Required?","attachmentId":74807502,"attachmentType":"pdf","work_url":"https://www.academia.edu/61888336/Tracking_the_Course_of_Hippocampal_Representations_during_Learning_When_Is_the_Map_Required","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/61888336/Tracking_the_Course_of_Hippocampal_Representations_during_Learning_When_Is_the_Map_Required"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="22" data-entity-id="51640527" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/51640527/Placing_memories_in_context_Hippocampal_representations_promote_retrieval_of_appropriate_memories">Placing memories in context: Hippocampal representations promote retrieval of appropriate memories</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63735" href="https://cornell.academia.edu/LMatthewLaw">L. Matthew Law</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hippocampus, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placing memories in context: Hippocampal representations promote retrieval of appropriate memories","attachmentId":69276129,"attachmentType":"pdf","work_url":"https://www.academia.edu/51640527/Placing_memories_in_context_Hippocampal_representations_promote_retrieval_of_appropriate_memories","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/51640527/Placing_memories_in_context_Hippocampal_representations_promote_retrieval_of_appropriate_memories"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="23323" href="https://www.academia.edu/Documents/in/Transcription_Factors">Transcription Factors</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="46858" href="https://www.academia.edu/Documents/in/Memory">Memory</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="132020" href="https://www.academia.edu/Documents/in/Neuronal_Plasticity">Neuronal Plasticity</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="147195" href="https://www.academia.edu/Documents/in/Central_Nervous_System">Central Nervous System</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1681026" href="https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology">Biochemistry and cell biology</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>