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data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div> <div class="video-color-overlay row-bg-layer" data-color=""></div> <div class="nectar-video-wrap row-bg-layer" data-bg-alignment=""> <div class="nectar-video-inner"> <video class="nectar-video-bg" width="1800" height="700" preload="auto" loop autoplay muted playsinline><source src="https://www.lumacyte.com/wp-content/uploads/2024/01/interior-pages-lumacyte-applications.mp4" type="video/webm"></video> </div> </div> <div class="row_col_wrap_12 col span_12 light left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col has-animation no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="fade-in" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div id="fws_67421c0d72228" data-midnight="" data-column-margin="default" class="wpb_row vc_row-fluid vc_row inner_row vc_row-o-equal-height vc_row-flex vc_row-o-content-middle" style="padding-top: 15%; padding-bottom: 14%; "><div class="row-bg-wrap"> <div class="row-bg" ></div> </div><div class="row_col_wrap_12_inner col span_12 left"> <div class="vc_col-sm-5 vc_col-xs-12 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h1>CAR T</h1> </div> </div> </div> </div> </div> <div class="vc_col-sm-1 vc_hidden-sm vc_hidden-xs wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> </div> </div> </div> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> </div> </div> </div> </div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d72a3c" data-column-margin="default" data-midnight="dark" data-top-percent="4%" data-bottom-percent="4%" class="wpb_row vc_row-fluid vc_row full-width-section right_padding_4pct left_padding_4pct" style="padding-top: calc(100vw * 0.04); padding-bottom: calc(100vw * 0.04); "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col no-extra-padding right_margin_4px left_margin_4px inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 40px;" class="divider"></div></div><div class="nectar-split-heading " data-align="center" data-m-align="inherit" data-text-effect="default" data-animation-type="line-reveal-by-space" data-animation-delay="0" data-animation-offset="" data-m-rm-animation="" data-stagger="true" data-custom-font-size="true" style="font-size: 36px; line-height: 38.88px;"><h2 style=" color: #3f6c7d;">T-Cell Activation and Cell Killing Analytics using Laser Force Cytology™</h2></div><div class="divider-wrap" data-alignment="center"><div style="margin-top: 10px; width: 20%px; height: 2px; margin-bottom: 10px;" data-width="20%" data-animate="" data-animation-delay="" data-color="extra-color-2" class="divider-small-border"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d731ae" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section right_margin_4px left_margin_4px right_padding_4px left_padding_4px" style="padding-top: 2px; padding-bottom: 2px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col padding-4-percent inherit_tablet inherit_phone " data-padding-pos="left" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span style="font-size: 13pt;"><span style="color: #3b3838;"><img fetchpriority="high" decoding="async" class="alignleft wp-image-5376 size-full" src="https://www.lumacyte.com/wp-content/uploads/2023/11/Screenshot-2023-11-10-112539.png" alt="" width="859" height="606" srcset="https://www.lumacyte.com/wp-content/uploads/2023/11/Screenshot-2023-11-10-112539.png 859w, https://www.lumacyte.com/wp-content/uploads/2023/11/Screenshot-2023-11-10-112539-300x212.png 300w, https://www.lumacyte.com/wp-content/uploads/2023/11/Screenshot-2023-11-10-112539-768x542.png 768w" sizes="(max-width: 859px) 100vw, 859px" /></span></span></p> </div> </div> </div> </div> </div> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span style="font-size: 13pt;"><span style="color: #1b2f36;">Gene modification cell therapy involves removing cells from a patient and genetically modifying them to introduce a new gene or correct a faulty existing gene. Chimeric antigen receptor (CAR)-T cell therapy is a key example, outlined in the figure on the left. First, T cells are removed from the patient (1) and can undergo qualification/testing which may predict outcome and guide the biomanufacturing process (1). The cells are then genetically modified through delivery of a new gene using a viral vector (2). This gene modification reprograms the T cells to recognize and attack a certain target cancer cell, thereby promoting specific cancer cell destruction and clearance. The next step in the process is to expand (3) or activate and expand/grow the modified T-cells into a large enough quantity, followed by potency testing and formulation (4) prior to infusing the modified cells into the patient (5) to treat their disease, in this case cancer.</span></span></p> <p><span style="font-size: 13pt;"><span style="color: #1b2f36;">Monitoring T-cell activation poses a critical challenge in cell therapies like CAR-T therapy, where precise control is paramount. Achieving the right balance in activation is challenging, as overstimulation may lead to exhaustion or adverse effects, while under-stimulation can compromise therapeutic efficacy. Developing robust and sensitive monitoring techniques is essential to ensuring optimal T-cell activation, addressing a key hurdle in the advancement and success of cell therapies.</span></span></p> </div> </div> </div> </div> </div> </div></div> <div id="fws_67421c0d736ee" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col left_padding_desktop_4pct right_padding_desktop_4pct bottom_padding_desktop_4pct " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 80px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d753cb" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="true"><div class="inner-wrap row-bg-layer using-image" ><div class="row-bg viewport-desktop using-image using-bg-color" style="background-position: left top; background-repeat: no-repeat; background-color: #ffffff; " data-nectar-img-src="https://www.lumacyte.com/wp-content/uploads/2024/01/shutterstock_1229814643-2-scaled.jpg"></div></div><div class="row-bg-overlay row-bg-layer" style="background-color:#b8062f; opacity: 0.8; "></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col padding-4-percent inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 50px;" class="divider"></div></div><div class="nectar-split-heading " data-align="center" data-m-align="inherit" data-text-effect="default" data-animation-type="line-reveal-by-space" data-animation-delay="0" data-animation-offset="" data-m-rm-animation="" data-stagger="" data-custom-font-size="true" style="font-size: 36px; line-height: 38.88px;"><h2 style=" color: #ffffff;">Using Laser Force Cytology™, Radiance® is able to effectively monitor and track critical quality attributes (CQA) and critical process parameters (CPP) within the process, quickly measuring the significant biochemical & biophysical changes to the cells during activation. This provides novel and resourceful insights into the condition of the cells and can correlate to the success or failure of the therapy within the patient.</h2></div><div class="divider-wrap" data-alignment="default"><div style="height: 50px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d7584b" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col left_padding_desktop_4pct right_padding_desktop_4pct bottom_padding_desktop_4pct " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 80px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d75ae0" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark center"> <div class="vc_col-sm-4 wpb_column column_container vc_column_container col padding-4-percent force-desktop-text-align-left inherit_tablet inherit_phone " data-padding-pos="left-right" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="iwithtext"><div class="iwt-icon"> <img decoding="async" src="https://www.lumacyte.com/wp-content/uploads/2024/01/blood-small-1-300x300.png" alt="" /> </div><div class="iwt-text"> <h4>Apheresis</h4> <p>Post apheresis, LFC™ can be used for qualification and testing of initial patient samples to understand donor-to-donor viability. </div><div class="clear"></div></div> </div> </div> </div> <div class="vc_col-sm-4 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="iwithtext"><div class="iwt-icon"> <img decoding="async" src="https://www.lumacyte.com/wp-content/uploads/2024/01/blood-small-1-300x300.png" alt="" /> </div><div class="iwt-text"> <h4 style="text-align: left;">Cell Expansion</h4> <p style="text-align: left;">LFC™ enables real-time monitoring of cell growth, viability, and phenotype, crucial for scaling up production.</p> </div><div class="clear"></div></div> </div> </div> </div> <div class="vc_col-sm-4 wpb_column column_container vc_column_container col no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="iwithtext"><div class="iwt-icon"> <img decoding="async" src="https://www.lumacyte.com/wp-content/uploads/2024/01/blood-small-1-300x300.png" alt="" /> </div><div class="iwt-text"> <h4 style="text-align: left;">Quality Control</h4> <p style="text-align: left;">LFC™ provides a robust tool for quality control, offering detailed insights into the final product’s characteristics, including viability, functionality, and safety.</p> </div><div class="clear"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d7ab64" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col left_padding_desktop_4pct right_padding_desktop_4pct bottom_padding_desktop_4pct " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <a class="nectar-button large regular extra-color-1 has-icon regular-button" style="margin-top: 60px; " href="https://www.lumacyte.com/applications/lumacyte-car-t-donor-patient-screening-service/" data-color-override="false" data-hover-color-override="false" data-hover-text-color-override="#fff"><span>CAR T Donor & Patient Screening Service</span><i class="icon-button-arrow"></i></a><div class="divider-wrap" data-alignment="default"><div style="height: 80px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d7b25c" data-column-margin="none" data-midnight="dark" data-top-percent="2%" data-bottom-percent="2%" class="wpb_row vc_row-fluid vc_row full-width-section vc_row-o-equal-height vc_row-flex vc_row-o-content-middle right_padding_4px left_padding_4px reverse_columns_column_tablet reverse_columns_column_phone bottom_padding_tablet_10pct" style="padding-top: calc(100vw * 0.02); padding-bottom: calc(100vw * 0.02); "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col padding-4-percent column_position_static el_spacing_30px inherit_tablet inherit_phone " data-padding-pos="left" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div id="fws_67421c0d7b55c" data-midnight="" data-column-margin="none" class="wpb_row vc_row-fluid vc_row inner_row right_padding_5pct top_padding_tablet_8pct" style=""><div class="row-bg-wrap"> <div class="row-bg" ></div> </div><div class="row_col_wrap_12_inner col span_12 left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="nectar-split-heading " data-align="left" data-m-align="inherit" data-text-effect="default" data-animation-type="line-reveal-by-space" data-animation-delay="0" data-animation-offset="" data-m-rm-animation="" data-stagger="true" data-custom-font-size="true" style="font-size: 36px; line-height: 38.88px;"><h2 style=" color: #3f6c7d;">Rapid Label-Free Monitoring of T-Cell Activation Analytics using Laser Force Cytology™</h2></div><div class="divider-wrap" data-alignment="default"><div style="margin-top: 12.5px; width: 20%px; height: 2px; margin-bottom: 12.5px;" data-width="20%" data-animate="" data-animation-delay="" data-color="extra-color-2" class="divider-small-border"></div></div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span style="font-size: 13pt;"><span style="color: #1b2f36;">Here we present LFC™ as a technology that enables a rapid and sensitive method of monitoring T-cell activation using a combination of optical pressure and microfluidics to measure intrinsic biophysical and biochemical changes in cells. The advanced label-free metrics measured by LFC gives it a distinct advantage over other process monitoring technologies that might require fluorescent labeling or other bias-inducing, time-consuming processing steps.</span></span></p> </div> </div> <a class="nectar-button large regular extra-color-1 has-icon regular-button" style="" href="https://www.lumacyte.com/resources/tech-notes/radiance-label-free-t-cell-activation-monitoring/" data-color-override="false" data-hover-color-override="false" data-hover-text-color-override="#fff"><span>Read More</span><i class="icon-button-arrow"></i></a> </div> </div> </div> </div></div> </div> </div> </div> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col centered-text padding-4-percent column_position_relative force-desktop-text-align-center el_spacing_0px inherit_tablet inherit_phone col-overflow-hidden " data-overlay-color="true" data-padding-pos="right" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" ><div class="column-bg-overlay-wrap column-bg-layer" data-bg-animation="none"><div class="column-bg-overlay"></div><div class="column-overlay-layer" style=""></div></div> <div class="wpb_wrapper"> <div class="img-with-aniamtion-wrap " data-max-width="100%" data-max-width-mobile="default" data-shadow="none" data-animation="none" > <div class="inner"> <div class="hover-wrap"> <div class="hover-wrap-inner"> <img decoding="async" class="img-with-animation skip-lazy nectar-lazy" data-delay="0" height="1161" width="1533" data-animation="none" data-nectar-img-src="https://www.lumacyte.com/wp-content/uploads/2024/01/radianceB-1.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201533%201161'%2F%3E" alt="Laser Force Cytology™" /> </div> </div> </div> </div> </div> </div> </div> </div></div> <div id="fws_67421c0d7c99e" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col left_padding_desktop_4pct right_padding_desktop_4pct bottom_padding_desktop_4pct " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 80px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d7cc7e" data-column-margin="none" data-midnight="dark" data-top-percent="2%" data-bottom-percent="2%" class="wpb_row vc_row-fluid vc_row full-width-section vc_row-o-equal-height vc_row-flex vc_row-o-content-middle right_padding_4px left_padding_4px reverse_columns_column_tablet reverse_columns_column_phone bottom_padding_tablet_10pct" style="padding-top: calc(100vw * 0.02); padding-bottom: calc(100vw * 0.02); "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col padding-4-percent column_position_static el_spacing_30px inherit_tablet inherit_phone " data-padding-pos="left" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div id="fws_67421c0d7cf7b" data-midnight="" data-column-margin="none" class="wpb_row vc_row-fluid vc_row inner_row right_padding_5pct top_padding_tablet_8pct" style=""><div class="row-bg-wrap"> <div class="row-bg" ></div> </div><div class="row_col_wrap_12_inner col span_12 left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col child_column no-extra-padding inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="img-with-aniamtion-wrap center" data-max-width="100%" data-max-width-mobile="default" data-shadow="none" data-animation="none" > <div class="inner"> <div class="hover-wrap"> <div class="hover-wrap-inner"> <img decoding="async" class="img-with-animation skip-lazy nectar-lazy" data-delay="0" height="1208" width="2496" data-animation="none" data-nectar-img-src="https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%202496%201208'%2F%3E" alt="" data-nectar-img-srcset="https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9.png 2496w, https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9-300x145.png 300w, https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9-1024x496.png 1024w, https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9-768x372.png 768w, https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9-1536x743.png 1536w, https://www.lumacyte.com/wp-content/uploads/2024/01/Picture9-2048x991.png 2048w" sizes="(max-width: 2496px) 100vw, 2496px" /> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> <div class="vc_col-sm-6 wpb_column column_container vc_column_container col padding-4-percent column_position_relative force-desktop-text-align-center el_spacing_0px inherit_tablet inherit_phone col-overflow-hidden " data-overlay-color="true" data-padding-pos="right" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" ><div class="column-bg-overlay-wrap column-bg-layer" data-bg-animation="none"><div class="column-bg-overlay"></div><div class="column-overlay-layer" style=""></div></div> <div class="wpb_wrapper"> <div class="nectar-split-heading " data-align="left" data-m-align="inherit" data-text-effect="default" data-animation-type="line-reveal-by-space" data-animation-delay="0" data-animation-offset="" data-m-rm-animation="" data-stagger="true" data-custom-font-size="true" style="font-size: 36px; line-height: 38.88px;"><h2 style=" color: #3f6c7d;">Detection of Mediated CAR-T Cell Killing</h2></div><div class="divider-wrap" data-alignment="default"><div style="margin-top: 12.5px; width: 20%px; height: 2px; margin-bottom: 12.5px;" data-width="20%" data-animate="" data-animation-delay="" data-color="extra-color-2" class="divider-small-border"></div></div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="text-align: left;"><strong>Changes in LFC™ metrics across populations can be used to measure cell killing across donors</strong></p> <p style="text-align: left;">The results shown demonstrate an LFC™ based in vitro assay to evaluate the efficacy of the CD19 CAR-Ts to kill target cells. The extent of cell killing of the NALM6 cells as measured by LFC™ is an indication of the potency of the CD19 CAR-T cells. Multiple ratios of Effector:Target cells (CAR-T cells:NALM6 cells) were tested to understand robustness of the killing efficiency across the 5 donors tested. As shown in the bar chart, Donors B and E show the highest killing across all 4 ratios, versus Donors C and D that show comparatievly less effective killing, especially when a lower number of effector CAR-T cells were added. The results demonstrate the capability of Radiance® to measure target cell killing in a rapid and label-free manner.</p> </div> </div> </div> </div> </div> </div></div> <div id="fws_67421c0d7e150" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col left_padding_desktop_4pct right_padding_desktop_4pct bottom_padding_desktop_4pct " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="divider-wrap" data-alignment="default"><div style="height: 80px;" class="divider"></div></div> </div> </div> </div> </div></div> <div id="fws_67421c0d7e3d3" data-column-margin="default" data-midnight="dark" class="wpb_row vc_row-fluid vc_row full-width-section" style="padding-top: 0px; padding-bottom: 0px; "><div class="row-bg-wrap" data-bg-animation="none" data-bg-animation-delay="" data-bg-overlay="false"><div class="inner-wrap row-bg-layer" ><div class="row-bg viewport-desktop using-bg-color" style="background-color: #ffffff; "></div></div></div><div class="row_col_wrap_12 col span_12 dark left"> <div class="vc_col-sm-12 wpb_column column_container vc_column_container col centered-text padding-4-percent inherit_tablet inherit_phone " data-padding-pos="all" data-has-bg-color="false" data-bg-color="" data-bg-opacity="1" data-animation="" data-delay="0" > <div class="vc_column-inner" > <div class="wpb_wrapper"> <div class="nectar-split-heading " data-align="default" data-m-align="inherit" data-text-effect="default" data-animation-type="line-reveal-by-space" data-animation-delay="0" data-animation-offset="" data-m-rm-animation="" data-stagger="" data-custom-font-size="true" style="font-size: 36px; line-height: 38.88px;"><h2 style=" color: #85b1c1;">How will you Harness the Power of Laser Force Cytology™ to Accelerate the Development and Production of Life Saving Therapies Faster than Ever Before?</h2></div><a class="nectar-button large regular extra-color-1 has-icon regular-button" style="color: #ffffff; " href="https://www.lumacyte.com/contact-us/" data-color-override="false" data-hover-color-override="false" data-hover-text-color-override="#fff"><span>Speak To An Expert</span><i style="color: #ffffff;" class="icon-button-arrow"></i></a><div class="divider-wrap" data-alignment="default"><div style="height: 50px;" class="divider"></div></div> </div> </div> </div> </div></div> </div> </div> </div> <div id="footer-outer" data-cols="5" data-custom-color="true" data-disable-copyright="false" data-matching-section-color="true" data-copyright-line="false" data-using-bg-img="false" data-bg-img-overlay="0.8" data-full-width="false" data-using-widget-area="true" data-link-hover="default"> <div id="footer-widgets" data-has-widgets="true" data-cols="5"> <div class="container"> <div class="row"> <div class="col span_3"> <div id="block-12" class="widget widget_block widget_media_image"> <figure class="wp-block-image size-large"><img fetchpriority="high" decoding="async" width="1024" height="264" src="https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023-1024x264.png" alt="" class="wp-image-6035" srcset="https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023-1024x264.png 1024w, https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023-300x77.png 300w, https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023-768x198.png 768w, https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023-1536x396.png 1536w, https://www.lumacyte.com/wp-content/uploads/2024/01/lumacyte-logo-2023.png 2000w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> </div><div id="block-8" class="widget widget_block widget_text"> <p class="dj-footer-txt has-text-color" style="color:#1b2f36">LumaCyte is an advanced research and bioanalytics instrumentation company that produces label-free, single cell analysis instrumentation where the use of antibody or genetic labeling is not required for cellular analysis. 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menu-item-has-icon menu-item-2855"><a href="https://www.lumacyte.com/products/radiance/illuminate/"><img width="500" height="500" src="https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon.png" class="nectar-menu-icon-img" alt="" decoding="async" srcset="https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon.png 500w, https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon-300x300.png 300w, https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon-150x150.png 150w, https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon-100x100.png 100w, https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon-140x140.png 140w, https://www.lumacyte.com/wp-content/uploads/2023/05/rad-icon-350x350.png 350w" sizes="(max-width: 500px) 100vw, 500px" /><span class="menu-title-text">Illuminate™</span><small class="item_desc">Radiance® single cell analysis software</small></a></li> </ul> </li> <li class="menu-item menu-item-type-custom menu-item-object-custom 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include viral infectivity for vaccine development and manufacturing, cell health, activation, transfection and transduction analytics for cell and gene therapy development and production monitoring, CAR T-cell immunotherapy, iPSC differentiation, adventitious agent testing (AAT), infectious disease, and pre-clinical drug discovery, in addition to multiple applications across advanced therapy biomanufacturing for real-time quality control.</span></div></div></a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children hide-title menu-item-2322"><a href="#">Technology</a> <ul class="sub-menu"> <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-icon menu-item-2323"><a href="https://www.lumacyte.com/applications/"><img width="500" height="500" src="https://www.lumacyte.com/wp-content/uploads/2023/05/cells.png" class="nectar-menu-icon-img" alt="" decoding="async" 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