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-webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Potassium</h1><div class="u-tcGrayDark">10,760 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Potassium</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Potassium">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Potassium/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Potassium/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Potassium/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Potassium">People</a></li></ul></div><style 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href="https://www.academia.edu/4609493/Mitochondrial_potassium_transport_the_role_of_the_mitochondrial_ATP_sensitive_K_channel_in_cardiac_function_and_cardioprotection">Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K + channel in cardiac function and cardioprotection</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4609493" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dfc9b977918bc23dd7a1a269e75c51ad" rel="nofollow" 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data-work_id="17448993" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17448993/THE_EFFECT_OF_HYDRIC_STRESS_AND_SOIL_ACIDITY_ON_SUNFLOWER_SEEDLINGS">THE EFFECT OF HYDRIC STRESS AND SOIL ACIDITY ON SUNFLOWER SEEDLINGS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This paper presents the effect of hydric stress on Select sunflower hybrid grown under near-neutral and acid soil conditions. The experiment was conducted in green - house with sunflower plants grown in PVC tubs filled with: near- neutral... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17448993" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This paper presents the effect of hydric stress on Select sunflower hybrid grown under near-neutral and acid soil conditions. The experiment was conducted in green - house with sunflower plants grown in PVC tubs filled with: near- neutral soil (pH = 6.2 ) (I), acid soil (pH = 5.27) (II) and ferti-lized acid soil ((phosphorus (100 kg/ha), potassium (100 kg/ha)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17448993" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d96cadba4ccb20ca8126e96e5a0a4c75" rel="nofollow" data-download="{"attachment_id":39514567,"asset_id":17448993,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39514567/download_file?st=MTczMzA1MzA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37191353" href="https://independent.academia.edu/ElenaPetcu3">Elena Petcu</a><script data-card-contents-for-user="37191353" type="text/json">{"id":37191353,"first_name":"Elena","last_name":"Petcu","domain_name":"independent","page_name":"ElenaPetcu3","display_name":"Elena Petcu","profile_url":"https://independent.academia.edu/ElenaPetcu3?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17448993 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17448993"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17448993, container: ".js-paper-rank-work_17448993", }); 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The experiment was conducted in green - house with sunflower plants grown in PVC tubs filled with: near- neutral soil (pH = 6.2 ) (I), acid soil (pH = 5.27) (II) and ferti-lized acid soil ((phosphorus (100 kg/ha), potassium (100 kg/ha)","downloadable_attachments":[{"id":39514567,"asset_id":17448993,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37191353,"first_name":"Elena","last_name":"Petcu","domain_name":"independent","page_name":"ElenaPetcu3","display_name":"Elena 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toxicity study of senna (Tinnevelly senna fruits) in the rat</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Senna (Tinnevelly senna fruits), a known laxative derived from plants, was administered by gavage to Sprague-Dawley (Crl:CD (SD) BR) rats once daily at dose levels of 0, 25, 100 and 300 mg/kg/day for up to 104 consecutive weeks. Based... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69517469" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Senna (Tinnevelly senna fruits), a known laxative derived from plants, was administered by gavage to Sprague-Dawley (Crl:CD (SD) BR) rats once daily at dose levels of 0, 25, 100 and 300 mg/kg/day for up to 104 consecutive weeks. Based upon clinical signs related to the laxation effect of senna, the highest dose (300 mg/kg/day) was considered to be a maximum tolerated dose. Sixty animals per sex were assigned to the control and dose groups. Assessments included clinical chemistry, hematology, full histology (control and high-dose groups; in addition, low and mid dose: intestinal tract, adrenals, liver, kidneys, brain and gross lesions) and toxicokinetics. The primary treatment-related clinical observation was mucoid feces seen at 300 mg/kg/day. When compared to controls, animals administered 300 mg/kg/day had slightly reduced body weights, increased water consumption and notable changes in electrolytes in serum (increases in potassium and chloride) and urine (decreases in sodium, pot...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69517469" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="31f70b4e0e24ed4f2951ee168bf2cfa4" rel="nofollow" data-download="{"attachment_id":79583481,"asset_id":69517469,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79583481/download_file?st=MTczMzA1MzA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="546293" href="https://independent.academia.edu/SharronMcPherson">Sharron McPherson</a><script data-card-contents-for-user="546293" type="text/json">{"id":546293,"first_name":"Sharron","last_name":"McPherson","domain_name":"independent","page_name":"SharronMcPherson","display_name":"Sharron McPherson","profile_url":"https://independent.academia.edu/SharronMcPherson?f_ri=160656","photo":"https://0.academia-photos.com/546293/196752/229358/s65_sharron.mcpherson.jpg"}</script></span></span></li><li class="js-paper-rank-work_69517469 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69517469"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69517469, container: ".js-paper-rank-work_69517469", }); 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Based upon clinical signs related to the laxation effect of senna, the highest dose (300 mg/kg/day) was considered to be a maximum tolerated dose. Sixty animals per sex were assigned to the control and dose groups. Assessments included clinical chemistry, hematology, full histology (control and high-dose groups; in addition, low and mid dose: intestinal tract, adrenals, liver, kidneys, brain and gross lesions) and toxicokinetics. The primary treatment-related clinical observation was mucoid feces seen at 300 mg/kg/day. 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catecholamine release from cultured chromaffin cells","created_at":"2021-04-21T16:33:53.434-07:00","url":"https://www.academia.edu/47365948/The_gadolinium_ion_a_potent_blocker_of_calcium_channels_and_catecholamine_release_from_cultured_chromaffin_cells?f_ri=160656","dom_id":"work_47365948","summary":null,"downloadable_attachments":[{"id":66495449,"asset_id":47365948,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":132294438,"first_name":"Jose-Maria","last_name":"Trifaro","domain_name":"independent","page_name":"JoseMariaTrifaro","display_name":"Jose-Maria 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work_4850860" data-work_id="4850860" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4850860/Purification_and_Characterization_of_Chitinases_from_the_Nematophagous_Fungi_Verticillium_chlamydosporium_and_V_suchlasporium">Purification and Characterization of Chitinases from the Nematophagous Fungi Verticillium chlamydosporium and V. suchlasporium</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4850860" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" 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Salinas","profile_url":"https://udec-cl.academia.edu/HansSalinas?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=160656","nofollow":false},{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=160656","nofollow":false},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=160656","nofollow":false},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=160656","nofollow":false},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology?f_ri=160656"},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=160656"},{"id":5398,"name":"Biotechnology","url":"https://www.academia.edu/Documents/in/Biotechnology?f_ri=160656"},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=160656"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=160656"},{"id":10655,"name":"Scanning Electron Microscopy","url":"https://www.academia.edu/Documents/in/Scanning_Electron_Microscopy?f_ri=160656"},{"id":14907,"name":"Industrial Biotechnology","url":"https://www.academia.edu/Documents/in/Industrial_Biotechnology?f_ri=160656"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=160656"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=160656"},{"id":55172,"name":"Streptomyces","url":"https://www.academia.edu/Documents/in/Streptomyces?f_ri=160656"},{"id":70061,"name":"Food Biochemistry","url":"https://www.academia.edu/Documents/in/Food_Biochemistry?f_ri=160656"},{"id":73035,"name":"Microbiology and Biotechnology","url":"https://www.academia.edu/Documents/in/Microbiology_and_Biotechnology?f_ri=160656"},{"id":74761,"name":"Industrial microbiology","url":"https://www.academia.edu/Documents/in/Industrial_microbiology?f_ri=160656"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction?f_ri=160656"},{"id":130447,"name":"Biocontrol","url":"https://www.academia.edu/Documents/in/Biocontrol?f_ri=160656"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature?f_ri=160656"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656"},{"id":205584,"name":"Solubility","url":"https://www.academia.edu/Documents/in/Solubility?f_ri=160656"},{"id":207536,"name":"Red Algae","url":"https://www.academia.edu/Documents/in/Red_Algae?f_ri=160656"},{"id":295729,"name":"Protein expression and purification","url":"https://www.academia.edu/Documents/in/Protein_expression_and_purification?f_ri=160656"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules?f_ri=160656"},{"id":371425,"name":"Electrophoresis","url":"https://www.academia.edu/Documents/in/Electrophoresis?f_ri=160656"},{"id":432129,"name":"Substrate Specificity","url":"https://www.academia.edu/Documents/in/Substrate_Specificity?f_ri=160656"},{"id":437728,"name":"Isoenzymes","url":"https://www.academia.edu/Documents/in/Isoenzymes?f_ri=160656"},{"id":461851,"name":"Diptera","url":"https://www.academia.edu/Documents/in/Diptera?f_ri=160656"},{"id":517824,"name":"Fungal Genetics and Biology","url":"https://www.academia.edu/Documents/in/Fungal_Genetics_and_Biology?f_ri=160656"},{"id":529713,"name":"Chitinase","url":"https://www.academia.edu/Documents/in/Chitinase?f_ri=160656"},{"id":564460,"name":"Protoplasts","url":"https://www.academia.edu/Documents/in/Protoplasts?f_ri=160656"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=160656"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=160656"},{"id":1137254,"name":"Hydrogen-Ion Concentration","url":"https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration?f_ri=160656"},{"id":1169238,"name":"Chitin","url":"https://www.academia.edu/Documents/in/Chitin?f_ri=160656"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=160656"},{"id":1746898,"name":"BASIDIOMYCOTA","url":"https://www.academia.edu/Documents/in/BASIDIOMYCOTA?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5627577" data-work_id="5627577" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5627577/Endothelin1_stimulates_insulin_secretion_by_direct_action_on_the_islets_of_Langerhans_in_mice">Endothelin1 stimulates insulin secretion by direct action on the islets of Langerhans in mice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor peptide, is secreted in response to insulin. Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5627577" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endothelin-1 (ET-1), a potent endothelium-derived vasoconstrictor peptide, is secreted in response to insulin. Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question arises whether ET-1 acts as a direct modulator of insulin secretion. To test this, we studied the effects of ET-1 on isolated mouse islets of Langerhans. ET-1 (1 nmol/l-1 Μmol/l) dose-dependently stimulated insulin secretion from islets incubated in the presence of 16.7 mmol/l glucose (p<0.05). The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose. Furthermore, ET-1 induced a large, transient increase in glucose-stimulated insulin secretion during islet perifusion in the presence (p<0.001), but not in the absence, of extracellular Ca2+. The rate of 45Ca2+-efflux from 45Ca2+-prelabelled islets was transiently stimulated by ET-1 during perifusion at 16.7 mmol/l glucose in the presence of extracellular Ca2+ (p<0.001). A short-lived increase in 45Ca2+-efflux was also observed in the absence of extracellular Ca2+ (p<0.05). It is suggested that the effects of ET-1 on insulin secretion are critically dependent on influx via Ca2+-channels. In addition, ET-1 transiently enhanced 86Rb+-efflux from 86Rb+-prelabelled islets both in the presence (p<0.001) and in the absence (p<0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability. Our study provides evidence that ET-1 stimulates insulin secretion via a direct effect on the islets of Langerhans.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5627577" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7e331444f57098cbe9af20cf69fd903f" rel="nofollow" data-download="{"attachment_id":49208635,"asset_id":5627577,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49208635/download_file?st=MTczMzA1MzA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8074246" href="https://rm.academia.edu/kjeldhermansen">kjeld hermansen</a><script data-card-contents-for-user="8074246" type="text/json">{"id":8074246,"first_name":"kjeld","last_name":"hermansen","domain_name":"rm","page_name":"kjeldhermansen","display_name":"kjeld hermansen","profile_url":"https://rm.academia.edu/kjeldhermansen?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5627577 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5627577"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5627577, container: ".js-paper-rank-work_5627577", }); 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Elevated circulating ET-1 levels have been found in patients with diabetes mellitus and vascular dysfunction. The question arises whether ET-1 acts as a direct modulator of insulin secretion. To test this, we studied the effects of ET-1 on isolated mouse islets of Langerhans. ET-1 (1 nmol/l-1 Μmol/l) dose-dependently stimulated insulin secretion from islets incubated in the presence of 16.7 mmol/l glucose (p\u003c0.05). The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose. Furthermore, ET-1 induced a large, transient increase in glucose-stimulated insulin secretion during islet perifusion in the presence (p\u003c0.001), but not in the absence, of extracellular Ca2+. The rate of 45Ca2+-efflux from 45Ca2+-prelabelled islets was transiently stimulated by ET-1 during perifusion at 16.7 mmol/l glucose in the presence of extracellular Ca2+ (p\u003c0.001). A short-lived increase in 45Ca2+-efflux was also observed in the absence of extracellular Ca2+ (p\u003c0.05). It is suggested that the effects of ET-1 on insulin secretion are critically dependent on influx via Ca2+-channels. In addition, ET-1 transiently enhanced 86Rb+-efflux from 86Rb+-prelabelled islets both in the presence (p\u003c0.001) and in the absence (p\u003c0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability. Our study provides evidence that ET-1 stimulates insulin secretion via a direct effect on the islets of Langerhans.","downloadable_attachments":[{"id":49208635,"asset_id":5627577,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8074246,"first_name":"kjeld","last_name":"hermansen","domain_name":"rm","page_name":"kjeldhermansen","display_name":"kjeld hermansen","profile_url":"https://rm.academia.edu/kjeldhermansen?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=160656","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=160656","nofollow":false},{"id":71289,"name":"Glucose","url":"https://www.academia.edu/Documents/in/Glucose?f_ri=160656","nofollow":false},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=160656","nofollow":false},{"id":71426,"name":"Insulin 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Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=160656"},{"id":539690,"name":"Endothelin-1","url":"https://www.academia.edu/Documents/in/Endothelin-1?f_ri=160656"},{"id":1705044,"name":"islets of Langerhans","url":"https://www.academia.edu/Documents/in/islets_of_Langerhans?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27915653" data-work_id="27915653" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27915653/Anaerobic_digestion_of_glycerol_derived_from_biodiesel_manufacturing">Anaerobic digestion of glycerol derived from biodiesel manufacturing</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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Santos","profile_url":"https://geobiotec.academia.edu/MariaAnaSantos?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2979,"name":"Manufacturing","url":"https://www.academia.edu/Documents/in/Manufacturing?f_ri=160656","nofollow":false},{"id":4749,"name":"Catalysis","url":"https://www.academia.edu/Documents/in/Catalysis?f_ri=160656","nofollow":false},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=160656","nofollow":false},{"id":5398,"name":"Biotechnology","url":"https://www.academia.edu/Documents/in/Biotechnology?f_ri=160656","nofollow":false},{"id":7892,"name":"Biodiesel","url":"https://www.academia.edu/Documents/in/Biodiesel?f_ri=160656"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=160656"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=160656"},{"id":59113,"name":"Anaerobic 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Loading Rate","url":"https://www.academia.edu/Documents/in/Organic_Loading_Rate?f_ri=160656"},{"id":1436040,"name":"Potassium Compounds","url":"https://www.academia.edu/Documents/in/Potassium_Compounds?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25756531" data-work_id="25756531" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25756531/Effect_of_sodium_zirconium_cyclosilicate_on_potassium_lowering_for_28_days_among_outpatients_with_hyperkalemia_the_HARMONIZE_randomized_clinical_trial">Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25756531" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine. To evaluate the efficacy and safety of zirconium cyclosilicate for 28 days in patients with hyperkalemia. HARMONIZE was a phase 3, multicenter, randomized, double-blind, placebo-controlled trial evaluating zirconium cyclosilicate in outpatients with hyperkalemia (serum potassium ≥5.1 mEq/L) recruited from 44 sites in the United States, Australia, and South Africa (March-August 2014). Patients (n = 258) received 10 g of zirconium cyclosilicate 3 times daily in the initial 48-hour open-label phase. Patients (n = 237) achieving normokalemia (3.5-5.0 mEq/L) were then randomized to receive zirconium cyclosilicate, 5 g (n = 45 patients), 10 g (n = 51), or 15 g (n = 56), or placebo (n = 85) daily for 28 days. The primary end point was mean serum potassium...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25756531" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8325adf35b408fcde591dd484bc7adb8" rel="nofollow" data-download="{"attachment_id":46112285,"asset_id":25756531,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46112285/download_file?st=MTczMzA1MzA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="29028972" href="https://independent.academia.edu/EdgarLerma">Edgar Lerma</a><script data-card-contents-for-user="29028972" type="text/json">{"id":29028972,"first_name":"Edgar","last_name":"Lerma","domain_name":"independent","page_name":"EdgarLerma","display_name":"Edgar Lerma","profile_url":"https://independent.academia.edu/EdgarLerma?f_ri=160656","photo":"https://0.academia-photos.com/29028972/8265461/19979550/s65_edgar.lerma.jpeg"}</script></span></span></li><li class="js-paper-rank-work_25756531 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25756531"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25756531, container: ".js-paper-rank-work_25756531", }); 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Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine. To evaluate the efficacy and safety of zirconium cyclosilicate for 28 days in patients with hyperkalemia. HARMONIZE was a phase 3, multicenter, randomized, double-blind, placebo-controlled trial evaluating zirconium cyclosilicate in outpatients with hyperkalemia (serum potassium ≥5.1 mEq/L) recruited from 44 sites in the United States, Australia, and South Africa (March-August 2014). Patients (n = 258) received 10 g of zirconium cyclosilicate 3 times daily in the initial 48-hour open-label phase. Patients (n = 237) achieving normokalemia (3.5-5.0 mEq/L) were then randomized to receive zirconium cyclosilicate, 5 g (n = 45 patients), 10 g (n = 51), or 15 g (n = 56), or placebo (n = 85) daily for 28 days. The primary end point was mean serum potassium...","downloadable_attachments":[{"id":46112285,"asset_id":25756531,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":29028972,"first_name":"Edgar","last_name":"Lerma","domain_name":"independent","page_name":"EdgarLerma","display_name":"Edgar Lerma","profile_url":"https://independent.academia.edu/EdgarLerma?f_ri=160656","photo":"https://0.academia-photos.com/29028972/8265461/19979550/s65_edgar.lerma.jpeg"}],"research_interests":[{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false},{"id":378991,"name":"Outpatients","url":"https://www.academia.edu/Documents/in/Outpatients?f_ri=160656","nofollow":false},{"id":382481,"name":"Edema","url":"https://www.academia.edu/Documents/in/Edema?f_ri=160656","nofollow":false},{"id":394496,"name":"Zirconium","url":"https://www.academia.edu/Documents/in/Zirconium?f_ri=160656","nofollow":false},{"id":1012885,"name":"Silicates","url":"https://www.academia.edu/Documents/in/Silicates?f_ri=160656"},{"id":1396115,"name":"Hyperkalemia","url":"https://www.academia.edu/Documents/in/Hyperkalemia?f_ri=160656"},{"id":1504413,"name":"JAMA","url":"https://www.academia.edu/Documents/in/JAMA?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17817851 coauthored" data-work_id="17817851" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17817851/Forage_production_response_of_Artemisia_herba_alba_to_variation_in_rainfall_and_changes_in_soil_conditions_in_arid_regions">Forage production response of Artemisia herba alba to variation in rainfall and changes in soil conditions in arid regions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">For this research, four sites with different characteristics (Dasht Abkan, Artesh, Dorahi Kosheh and Scale Abad regions of the Khash city in southeastern part of Iran) were selected, and the one hectare land of the research area at each... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17817851" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">For this research, four sites with different characteristics (Dasht Abkan, Artesh, Dorahi Kosheh and Scale Abad regions of the Khash city in southeastern part of Iran) were selected, and the one hectare land of the research area at each location was fenced. Twenty 1 m x 1 m plots were randomly (completely randomized design) selected at each site. One soil sample was taken from the 0-45 cm depth at each location and analyzed for pH, EC, ESP, CaCO3, organic carbon, potassium, nitrogen, phosphorus and calcium. Rainfall was collected daily and measured at each location. The parameters measured included canopy surface area, plant height, litter, stem density, bare soil area and rock cover percentage, number of dry species, annual forage products and number of the established plants. Although, Artemisia cover shows a poor range stand in this research area, it has a high value in dry regions, and it has been extensively grazed by goat and sheep in this region. It was a sever drought during...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17817851" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e36bac211ba9ff9f66f23ebdb9ccec51" rel="nofollow" data-download="{"attachment_id":39727271,"asset_id":17817851,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39727271/download_file?st=MTczMzA1MzA1OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37739675" href="https://independent.academia.edu/MohammadPessarakli">Mohammad Pessarakli</a><script data-card-contents-for-user="37739675" type="text/json">{"id":37739675,"first_name":"Mohammad","last_name":"Pessarakli","domain_name":"independent","page_name":"MohammadPessarakli","display_name":"Mohammad Pessarakli","profile_url":"https://independent.academia.edu/MohammadPessarakli?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-17817851">+1</span><div class="hidden js-additional-users-17817851"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MohamadPesarakli">Mohamad Pesarakli</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17817851'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17817851').html(); 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Twenty 1 m x 1 m plots were randomly (completely randomized design) selected at each site. One soil sample was taken from the 0-45 cm depth at each location and analyzed for pH, EC, ESP, CaCO3, organic carbon, potassium, nitrogen, phosphorus and calcium. Rainfall was collected daily and measured at each location. The parameters measured included canopy surface area, plant height, litter, stem density, bare soil area and rock cover percentage, number of dry species, annual forage products and number of the established plants. Although, Artemisia cover shows a poor range stand in this research area, it has a high value in dry regions, and it has been extensively grazed by goat and sheep in this region. It was a sever drought during...","downloadable_attachments":[{"id":39727271,"asset_id":17817851,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37739675,"first_name":"Mohammad","last_name":"Pessarakli","domain_name":"independent","page_name":"MohammadPessarakli","display_name":"Mohammad Pessarakli","profile_url":"https://independent.academia.edu/MohammadPessarakli?f_ri=160656","photo":"/images/s65_no_pic.png"},{"id":37790930,"first_name":"Mohamad","last_name":"Pesarakli","domain_name":"independent","page_name":"MohamadPesarakli","display_name":"Mohamad Pesarakli","profile_url":"https://independent.academia.edu/MohamadPesarakli?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":53108,"name":"Phosphorus","url":"https://www.academia.edu/Documents/in/Phosphorus?f_ri=160656","nofollow":false},{"id":151091,"name":"Nitrogen","url":"https://www.academia.edu/Documents/in/Nitrogen?f_ri=160656","nofollow":false},{"id":156973,"name":"Artemisia","url":"https://www.academia.edu/Documents/in/Artemisia?f_ri=160656","nofollow":false},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false},{"id":261662,"name":"Arid Region","url":"https://www.academia.edu/Documents/in/Arid_Region?f_ri=160656"},{"id":345845,"name":"Soil Structure","url":"https://www.academia.edu/Documents/in/Soil_Structure?f_ri=160656"},{"id":386356,"name":"Surface Area","url":"https://www.academia.edu/Documents/in/Surface_Area?f_ri=160656"},{"id":454574,"name":"Soil Organic Carbon","url":"https://www.academia.edu/Documents/in/Soil_Organic_Carbon?f_ri=160656"},{"id":585192,"name":"Organic carbon","url":"https://www.academia.edu/Documents/in/Organic_carbon?f_ri=160656"},{"id":1277641,"name":"Soil Texture","url":"https://www.academia.edu/Documents/in/Soil_Texture?f_ri=160656"},{"id":1881217,"name":"Plant Height","url":"https://www.academia.edu/Documents/in/Plant_Height?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73007637" data-work_id="73007637" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73007637/First_WNK4_Hypokalemia_Animal_Model_Identified_by_Genome_Wide_Association_in_Burmese_Cats">First WNK4-Hypokalemia Animal Model Identified by Genome-Wide Association in Burmese Cats</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73007637" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c14a7b671a7b7e5508bcd2afca67bb17" rel="nofollow" data-download="{"attachment_id":81701202,"asset_id":73007637,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81701202/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1761482" href="https://ucdavis.academia.edu/FelineGeneticist">Feline Geneticist</a><script data-card-contents-for-user="1761482" type="text/json">{"id":1761482,"first_name":"Feline","last_name":"Geneticist","domain_name":"ucdavis","page_name":"FelineGeneticist","display_name":"Feline Geneticist","profile_url":"https://ucdavis.academia.edu/FelineGeneticist?f_ri=160656","photo":"https://0.academia-photos.com/1761482/2673989/3112141/s65_feline.geneticist.jpg"}</script></span></span></li><li class="js-paper-rank-work_73007637 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73007637"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73007637, container: ".js-paper-rank-work_73007637", }); 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The etiology of myocardial dysfunction is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_65020302" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">An imbalance in electrolyte concentration during separation from cardiopulmonary bypass (CPB) may lead to a disruption in excitation-contraction coupling resulting in a failure to wean. The etiology of myocardial dysfunction is multifactorial, and includes alterations in acid-base balance, glucose metabolism, and cellular function. The purpose of this study was to assess the effect of hyperkalemia on myocardial function during separation from CPB. A porcine model (n = 5) of hypothermic (32 degrees C) CPB was used where hyperkalemia [K+ (6.5 +/- 1.0)] was created before weaning. A 3-minute weaning process was initiated once normothermia was achieved. Mixed venous and arterial samples were obtained during CPB, weaning, and 10 minutes postbypass. Samples were assayed for [K+], [Ca++], glucose, pH, CPK-MB, and lactic acid levels. Hyperkalemia resulted in the generation of severe arrhythmias in all animals. During the immediate prewean period, there was a significant correlation between ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65020302" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="42bcd265be63193c0ddc928e1708d171" rel="nofollow" data-download="{"attachment_id":76787566,"asset_id":65020302,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76787566/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38054889" href="https://independent.academia.edu/CraigPetterson">Craig Petterson</a><script data-card-contents-for-user="38054889" type="text/json">{"id":38054889,"first_name":"Craig","last_name":"Petterson","domain_name":"independent","page_name":"CraigPetterson","display_name":"Craig Petterson","profile_url":"https://independent.academia.edu/CraigPetterson?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_65020302 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65020302"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65020302, container: ".js-paper-rank-work_65020302", }); 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The etiology of myocardial dysfunction is multifactorial, and includes alterations in acid-base balance, glucose metabolism, and cellular function. The purpose of this study was to assess the effect of hyperkalemia on myocardial function during separation from CPB. A porcine model (n = 5) of hypothermic (32 degrees C) CPB was used where hyperkalemia [K+ (6.5 +/- 1.0)] was created before weaning. A 3-minute weaning process was initiated once normothermia was achieved. Mixed venous and arterial samples were obtained during CPB, weaning, and 10 minutes postbypass. Samples were assayed for [K+], [Ca++], glucose, pH, CPK-MB, and lactic acid levels. Hyperkalemia resulted in the generation of severe arrhythmias in all animals. 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thiamacrocycles","created_at":"2021-09-12T23:47:01.342-07:00","url":"https://www.academia.edu/52082889/A_novel_approach_to_conformationally_strained_2_2_bipyridine_thiacrown_ethers_and_their_chiral_sulfoxides_by_sequential_homo_coupling_DA_rDA_reaction_of_5_5_bi_1_2_4_triazine_containing_thiamacrocycles?f_ri=160656","dom_id":"work_52082889","summary":null,"downloadable_attachments":[{"id":69511311,"asset_id":52082889,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":130488931,"first_name":"Danuta","last_name":"Branowska","domain_name":"independent","page_name":"DanutaBranowska","display_name":"Danuta Branowska","profile_url":"https://independent.academia.edu/DanutaBranowska?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=160656","nofollow":false},{"id":50630,"name":"Crystal 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href="https://www.academia.edu/1530616/Potassium_dodecatungstocobaltate_trihydrate_K_5CoW_12O_40_3H_2O_A_mild_and_efficient_reusable_catalyst_for_the_synthesis_of_amidoalkyl_naphthols_in_solution_and_under_solvent_free_conditions">Potassium dodecatungstocobaltate trihydrate (K 5CoW 12O 40 · 3H 2O): A mild and efficient reusable catalyst for the synthesis of amidoalkyl naphthols in solution and under solvent-free conditions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, β-naphthol and urea or amides, in the presence of potassium dodecatungstocobaltate trihydrate... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1530616" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">An efficient and direct procedure has been developed for the preparation of amidoalkyl naphthols by a one-pot condensation of aryl aldehydes, β-naphthol and urea or amides, in the presence of potassium dodecatungstocobaltate trihydrate [K5CoW12O40 · 3H2O, (1 mol%)] as a heterogeneous catalyst. The reactions were carried out in 1,2-dichloroethane at room temperature or under solvent-free media at elevated temperature. The present methodology offers several advantages such as excellent yields, simple procedure and the catalyst exhibited remarkable reusability.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1530616" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="03621627603bace0d57dff65ddb27aed" rel="nofollow" data-download="{"attachment_id":50940835,"asset_id":1530616,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50940835/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="1646003" href="https://iictindia.academia.edu/SriniKante">Srini Kante</a><script data-card-contents-for-user="1646003" type="text/json">{"id":1646003,"first_name":"Srini","last_name":"Kante","domain_name":"iictindia","page_name":"SriniKante","display_name":"Srini Kante","profile_url":"https://iictindia.academia.edu/SriniKante?f_ri=160656","photo":"https://0.academia-photos.com/1646003/154874837/144493449/s65_srini.kante.png"}</script></span></span></li><li class="js-paper-rank-work_1530616 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1530616"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1530616, container: ".js-paper-rank-work_1530616", }); 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The reactions were carried out in 1,2-dichloroethane at room temperature or under solvent-free media at elevated temperature. 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class="u-tcGrayDark u-fw700" data-has-card-for-user="6519178" href="https://iranpolymerinstitute.academia.edu/mohammadyousefi">mohammad yousefi</a><script data-card-contents-for-user="6519178" type="text/json">{"id":6519178,"first_name":"mohammad","last_name":"yousefi","domain_name":"iranpolymerinstitute","page_name":"mohammadyousefi","display_name":"mohammad yousefi","profile_url":"https://iranpolymerinstitute.academia.edu/mohammadyousefi?f_ri=160656","photo":"https://0.academia-photos.com/6519178/2798301/3263081/s65_mohammad.yousefi.jpg"}</script></span></span></li><li class="js-paper-rank-work_4952198 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4952198"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4952198, container: ".js-paper-rank-work_4952198", }); });</script></li><li class="js-percentile-work_4952198 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yousefi","profile_url":"https://iranpolymerinstitute.academia.edu/mohammadyousefi?f_ri=160656","photo":"https://0.academia-photos.com/6519178/2798301/3263081/s65_mohammad.yousefi.jpg"}],"research_interests":[{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=160656","nofollow":false},{"id":25600,"name":"Stability","url":"https://www.academia.edu/Documents/in/Stability?f_ri=160656","nofollow":false},{"id":59724,"name":"Optical 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js-work-card work_7912535" data-work_id="7912535" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7912535/The_potential_of_glauconitic_sandstone_as_a_potassium_fertilizer_for_olive_plants">The potential of glauconitic sandstone as a potassium fertilizer for olive plants</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This study evaluated the potential of glauconitic sandstone as a fertilizer for supplying potassium to plants. The glauconite sandstone (Maraveh, Iran), as analyzed by X-ray fluorescence, was composed of 2.24% potassium oxide plus high... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7912535" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This study evaluated the potential of glauconitic sandstone as a fertilizer for supplying potassium to plants. The glauconite sandstone (Maraveh, Iran), as analyzed by X-ray fluorescence, was composed of 2.24% potassium oxide plus high contents of silicon, aluminum and ferric oxide. One-year old olive trees, Olea europaea L., were grown in sand or hydroponic culture in a greenhouse under three potassium treatments. Modified Hoagland nutrient solutions based on potassium treatments including 0.5 mM K+, 5 mM K+ and 400 g glauconitic sandstone powders (per 10 L in hydroponics and per 2.5 L in sand instead of K+ supply) were used in both cultures. Plants grown under the three different potassium treatments did not show any potassium deficiency symptoms. In the sand culture, growth and potassium content were higher in plants fed with 5 mM potassium than with the other two potassium treatments. Growth retardation and decreased potassium content in plants fed with 0.5 mM potassium were more severe in the hydroponic culture than in the sand culture. However, plants fed with 400 g glauconitic sandstone showed higher growth in the hydroponic culture than the sand culture. Thus, glauconitic sandstone has the ability to release potassium and can be utilized in combination with other potassium fertilizers.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7912535" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f49b23c1b54cc909d9e599c1a27eaf03" rel="nofollow" data-download="{"attachment_id":48292732,"asset_id":7912535,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48292732/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="14838154" href="https://independent.academia.edu/EhsanKarimi3">Ehsan Karimi</a><script data-card-contents-for-user="14838154" type="text/json">{"id":14838154,"first_name":"Ehsan","last_name":"Karimi","domain_name":"independent","page_name":"EhsanKarimi3","display_name":"Ehsan Karimi","profile_url":"https://independent.academia.edu/EhsanKarimi3?f_ri=160656","photo":"https://0.academia-photos.com/14838154/4045111/4719948/s65_ehsan.karimi.jpg"}</script></span></span></li><li class="js-paper-rank-work_7912535 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7912535"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7912535, container: ".js-paper-rank-work_7912535", }); 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$(".js-view-count[data-work-id=7912535]").text(description); $(".js-view-count-work_7912535").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7912535").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7912535"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="14292" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a>, <script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="58054" href="https://www.academia.edu/Documents/in/Environmental_Sciences">Environmental Sciences</a>, <script data-card-contents-for-ri="58054" type="text/json">{"id":58054,"name":"Environmental Sciences","url":"https://www.academia.edu/Documents/in/Environmental_Sciences?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="160656" href="https://www.academia.edu/Documents/in/Potassium">Potassium</a><script data-card-contents-for-ri="160656" type="text/json">{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7912535]'), work: {"id":7912535,"title":"The potential of glauconitic sandstone as a potassium fertilizer for olive plants","created_at":"2014-08-07T18:05:46.872-07:00","url":"https://www.academia.edu/7912535/The_potential_of_glauconitic_sandstone_as_a_potassium_fertilizer_for_olive_plants?f_ri=160656","dom_id":"work_7912535","summary":"This study evaluated the potential of glauconitic sandstone as a fertilizer for supplying potassium to plants. The glauconite sandstone (Maraveh, Iran), as analyzed by X-ray fluorescence, was composed of 2.24% potassium oxide plus high contents of silicon, aluminum and ferric oxide. One-year old olive trees, Olea europaea L., were grown in sand or hydroponic culture in a greenhouse under three potassium treatments. Modified Hoagland nutrient solutions based on potassium treatments including 0.5 mM K+, 5 mM K+ and 400 g glauconitic sandstone powders (per 10 L in hydroponics and per 2.5 L in sand instead of K+ supply) were used in both cultures. Plants grown under the three different potassium treatments did not show any potassium deficiency symptoms. In the sand culture, growth and potassium content were higher in plants fed with 5 mM potassium than with the other two potassium treatments. Growth retardation and decreased potassium content in plants fed with 0.5 mM potassium were more severe in the hydroponic culture than in the sand culture. However, plants fed with 400 g glauconitic sandstone showed higher growth in the hydroponic culture than the sand culture. Thus, glauconitic sandstone has the ability to release potassium and can be utilized in combination with other potassium fertilizers.","downloadable_attachments":[{"id":48292732,"asset_id":7912535,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":14838154,"first_name":"Ehsan","last_name":"Karimi","domain_name":"independent","page_name":"EhsanKarimi3","display_name":"Ehsan Karimi","profile_url":"https://independent.academia.edu/EhsanKarimi3?f_ri=160656","photo":"https://0.academia-photos.com/14838154/4045111/4719948/s65_ehsan.karimi.jpg"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=160656","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=160656","nofollow":false},{"id":58054,"name":"Environmental 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data-work_id="64803356" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64803356/A_Metabolic_Biofuel_Cell_Conversion_of_Human_Leukocyte_Metabolic_Activity_to_Electrical_Currents">A Metabolic Biofuel Cell: Conversion of Human Leukocyte Metabolic Activity to Electrical Currents</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">An investigation of the electrochemical activity of human white blood cells (WBC) for biofuel cell (BFC) applications is described. WBCs isolated from whole human blood were suspended in PBS and introduced into the anode compartment of a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64803356" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">An investigation of the electrochemical activity of human white blood cells (WBC) for biofuel cell (BFC) applications is described. WBCs isolated from whole human blood were suspended in PBS and introduced into the anode compartment of a proton exchange membrane (PEM) fuel cell. The cathode compartment contained a 50 mM potassium ferricyanide solution. Average current densities between 0.9 and 1.6 μA cm-2 and open circuit potentials (Voc) between 83 and 102 mV were obtained, which were both higher than control values. Cyclic voltammetry was used to investigate the electrochemical activity of the activated WBCs in an attempt to elucidate the mechanism of electron transfer between the cells and electrode. Voltammograms were obtained for the WBCs, including peripheral blood mononuclear cells (PBMCs - a lymphocyte-monocyte mixture isolated on a Ficoll gradient), a B lymphoblastoid cell line (BLCL), and two leukemia cell lines, namely K562 and Jurkat. An oxidation peak at about 363 mV vs...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64803356" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a8574e61f906b7c7b9051b5d92bc0e98" rel="nofollow" data-download="{"attachment_id":76668360,"asset_id":64803356,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76668360/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26557984" href="https://independent.academia.edu/YingzeZhang">Yingze Zhang</a><script data-card-contents-for-user="26557984" type="text/json">{"id":26557984,"first_name":"Yingze","last_name":"Zhang","domain_name":"independent","page_name":"YingzeZhang","display_name":"Yingze Zhang","profile_url":"https://independent.academia.edu/YingzeZhang?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_64803356 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64803356"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64803356, container: ".js-paper-rank-work_64803356", }); 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WBCs isolated from whole human blood were suspended in PBS and introduced into the anode compartment of a proton exchange membrane (PEM) fuel cell. The cathode compartment contained a 50 mM potassium ferricyanide solution. Average current densities between 0.9 and 1.6 μA cm-2 and open circuit potentials (Voc) between 83 and 102 mV were obtained, which were both higher than control values. Cyclic voltammetry was used to investigate the electrochemical activity of the activated WBCs in an attempt to elucidate the mechanism of electron transfer between the cells and electrode. Voltammograms were obtained for the WBCs, including peripheral blood mononuclear cells (PBMCs - a lymphocyte-monocyte mixture isolated on a Ficoll gradient), a B lymphoblastoid cell line (BLCL), and two leukemia cell lines, namely K562 and Jurkat. An oxidation peak at about 363 mV vs...","downloadable_attachments":[{"id":76668360,"asset_id":64803356,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26557984,"first_name":"Yingze","last_name":"Zhang","domain_name":"independent","page_name":"YingzeZhang","display_name":"Yingze Zhang","profile_url":"https://independent.academia.edu/YingzeZhang?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=160656","nofollow":false},{"id":8963,"name":"Proton Exchange Membrane","url":"https://www.academia.edu/Documents/in/Proton_Exchange_Membrane?f_ri=160656","nofollow":false},{"id":20902,"name":"Cyclic Voltammetry","url":"https://www.academia.edu/Documents/in/Cyclic_Voltammetry?f_ri=160656","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=160656","nofollow":false},{"id":32095,"name":"Biological Engineering","url":"https://www.academia.edu/Documents/in/Biological_Engineering?f_ri=160656"},{"id":51565,"name":"Serotonin","url":"https://www.academia.edu/Documents/in/Serotonin?f_ri=160656"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=160656"},{"id":83359,"name":"Electron Transfer","url":"https://www.academia.edu/Documents/in/Electron_Transfer?f_ri=160656"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656"},{"id":173959,"name":"Current Density","url":"https://www.academia.edu/Documents/in/Current_Density?f_ri=160656"},{"id":199105,"name":"PEM fuel cell","url":"https://www.academia.edu/Documents/in/PEM_fuel_cell?f_ri=160656"},{"id":1208789,"name":"Open Circuit Potential","url":"https://www.academia.edu/Documents/in/Open_Circuit_Potential?f_ri=160656"},{"id":1275194,"name":"White Blood Cell","url":"https://www.academia.edu/Documents/in/White_Blood_Cell?f_ri=160656"},{"id":1310183,"name":"Phorbol ester","url":"https://www.academia.edu/Documents/in/Phorbol_ester?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_56422100" data-work_id="56422100" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/56422100/Potassium_Amphibole_Stability_in_the_Upper_Mantle_an_Experimental_Study_in_a_Peralkaline_KNCMASH_System_to_8_5_GPa">Potassium Amphibole Stability in the Upper Mantle: an Experimental Study in a Peralkaline KNCMASH System to 8.5 GPa</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/56422100" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="61322438727dabe5dc5023d3c8b15ac0" rel="nofollow" data-download="{"attachment_id":71817258,"asset_id":56422100,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71817258/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="98201292" href="https://ethz.academia.edu/PeterUlmer">Peter Ulmer</a><script data-card-contents-for-user="98201292" type="text/json">{"id":98201292,"first_name":"Peter","last_name":"Ulmer","domain_name":"ethz","page_name":"PeterUlmer","display_name":"Peter Ulmer","profile_url":"https://ethz.academia.edu/PeterUlmer?f_ri=160656","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_56422100 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="56422100"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 56422100, container: ".js-paper-rank-work_56422100", }); 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$(".js-view-count[data-work-id=56422100]").text(description); $(".js-view-count-work_56422100").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_56422100").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="56422100"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="406" href="https://www.academia.edu/Documents/in/Geology">Geology</a>, <script data-card-contents-for-ri="406" type="text/json">{"id":406,"name":"Geology","url":"https://www.academia.edu/Documents/in/Geology?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="407" href="https://www.academia.edu/Documents/in/Geochemistry">Geochemistry</a>, <script data-card-contents-for-ri="407" type="text/json">{"id":407,"name":"Geochemistry","url":"https://www.academia.edu/Documents/in/Geochemistry?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2404" href="https://www.academia.edu/Documents/in/Petrology">Petrology</a>, <script data-card-contents-for-ri="2404" type="text/json">{"id":2404,"name":"Petrology","url":"https://www.academia.edu/Documents/in/Petrology?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="134398" href="https://www.academia.edu/Documents/in/Mantle_metasomatism">Mantle metasomatism</a><script data-card-contents-for-ri="134398" type="text/json">{"id":134398,"name":"Mantle metasomatism","url":"https://www.academia.edu/Documents/in/Mantle_metasomatism?f_ri=160656","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=56422100]'), work: {"id":56422100,"title":"Potassium Amphibole Stability in the Upper Mantle: an Experimental Study in a Peralkaline KNCMASH System to 8.5 GPa","created_at":"2021-10-07T19:46:03.271-07:00","url":"https://www.academia.edu/56422100/Potassium_Amphibole_Stability_in_the_Upper_Mantle_an_Experimental_Study_in_a_Peralkaline_KNCMASH_System_to_8_5_GPa?f_ri=160656","dom_id":"work_56422100","summary":null,"downloadable_attachments":[{"id":71817258,"asset_id":56422100,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":98201292,"first_name":"Peter","last_name":"Ulmer","domain_name":"ethz","page_name":"PeterUlmer","display_name":"Peter Ulmer","profile_url":"https://ethz.academia.edu/PeterUlmer?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":406,"name":"Geology","url":"https://www.academia.edu/Documents/in/Geology?f_ri=160656","nofollow":false},{"id":407,"name":"Geochemistry","url":"https://www.academia.edu/Documents/in/Geochemistry?f_ri=160656","nofollow":false},{"id":2404,"name":"Petrology","url":"https://www.academia.edu/Documents/in/Petrology?f_ri=160656","nofollow":false},{"id":134398,"name":"Mantle metasomatism","url":"https://www.academia.edu/Documents/in/Mantle_metasomatism?f_ri=160656","nofollow":false},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656"},{"id":215075,"name":"Experimental Study","url":"https://www.academia.edu/Documents/in/Experimental_Study?f_ri=160656"},{"id":2218114,"name":"Frequency of occurrence","url":"https://www.academia.edu/Documents/in/Frequency_of_occurrence?f_ri=160656"},{"id":3057331,"name":"Transition Zone","url":"https://www.academia.edu/Documents/in/Transition_Zone?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_54647911" data-work_id="54647911" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/54647911/mTORC2_critically_regulates_renal_potassium_handling">mTORC2 critically regulates renal potassium handling</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized. Here, we generated mice lacking... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_54647911" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized. Here, we generated mice lacking mTORC2 in the distal tubule (Rictorfl/fl Ksp-Cre mice), which were viable and had no obvious phenotype, except for a 2.5-fold increase in plasma aldosterone. Challenged with a low-Na+ diet, these mice adequately reduced Na+ excretion; however, Rictorfl/fl Ksp-Cre mice rapidly developed hyperkalemia on a high-K+ diet, despite a 10-fold increase in serum aldosterone levels, implying that mTORC2 regulates kaliuresis. Phosphorylation of serum- and glucocorticoid-inducible kinase 1 (SGK1) and PKC-α was absent in Rictorfl/fl Ksp-Cre mice, indicating a functional block in K+ secretion activation via ROMK channels. Indeed, patch-clamp experiments on split-open tubular segments from the transition zone of the late connecting tubule and early cortical collectin...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54647911" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ef248a8138f403fc1bd460fb069ab71f" rel="nofollow" data-download="{"attachment_id":70911909,"asset_id":54647911,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70911909/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="173905877" href="https://independent.academia.edu/ViatcheslavNesterov">Viatcheslav Nesterov</a><script data-card-contents-for-user="173905877" type="text/json">{"id":173905877,"first_name":"Viatcheslav","last_name":"Nesterov","domain_name":"independent","page_name":"ViatcheslavNesterov","display_name":"Viatcheslav Nesterov","profile_url":"https://independent.academia.edu/ViatcheslavNesterov?f_ri=160656","photo":"https://0.academia-photos.com/173905877/162373445/152132960/s65_viatcheslav.nesterov.png"}</script></span></span></li><li class="js-paper-rank-work_54647911 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="54647911"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 54647911, container: ".js-paper-rank-work_54647911", }); 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$(".js-view-count[data-work-id=54647911]").text(description); $(".js-view-count-work_54647911").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_54647911").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="54647911"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="84760" href="https://www.academia.edu/Documents/in/Mice">Mice</a>, <script data-card-contents-for-ri="84760" type="text/json">{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="160656" href="https://www.academia.edu/Documents/in/Potassium">Potassium</a>, <script data-card-contents-for-ri="160656" type="text/json">{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1144154" href="https://www.academia.edu/Documents/in/Clinical_Investigation">Clinical Investigation</a>, <script data-card-contents-for-ri="1144154" type="text/json">{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1396115" href="https://www.academia.edu/Documents/in/Hyperkalemia">Hyperkalemia</a><script data-card-contents-for-ri="1396115" type="text/json">{"id":1396115,"name":"Hyperkalemia","url":"https://www.academia.edu/Documents/in/Hyperkalemia?f_ri=160656","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54647911]'), work: {"id":54647911,"title":"mTORC2 critically regulates renal potassium handling","created_at":"2021-10-01T09:20:39.654-07:00","url":"https://www.academia.edu/54647911/mTORC2_critically_regulates_renal_potassium_handling?f_ri=160656","dom_id":"work_54647911","summary":"The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized. Here, we generated mice lacking mTORC2 in the distal tubule (Rictorfl/fl Ksp-Cre mice), which were viable and had no obvious phenotype, except for a 2.5-fold increase in plasma aldosterone. Challenged with a low-Na+ diet, these mice adequately reduced Na+ excretion; however, Rictorfl/fl Ksp-Cre mice rapidly developed hyperkalemia on a high-K+ diet, despite a 10-fold increase in serum aldosterone levels, implying that mTORC2 regulates kaliuresis. Phosphorylation of serum- and glucocorticoid-inducible kinase 1 (SGK1) and PKC-α was absent in Rictorfl/fl Ksp-Cre mice, indicating a functional block in K+ secretion activation via ROMK channels. Indeed, patch-clamp experiments on split-open tubular segments from the transition zone of the late connecting tubule and early cortical collectin...","downloadable_attachments":[{"id":70911909,"asset_id":54647911,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":173905877,"first_name":"Viatcheslav","last_name":"Nesterov","domain_name":"independent","page_name":"ViatcheslavNesterov","display_name":"Viatcheslav Nesterov","profile_url":"https://independent.academia.edu/ViatcheslavNesterov?f_ri=160656","photo":"https://0.academia-photos.com/173905877/162373445/152132960/s65_viatcheslav.nesterov.png"}],"research_interests":[{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=160656","nofollow":false},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false},{"id":1144154,"name":"Clinical 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type="text/json">{"id":70902,"name":"Magnesium","url":"https://www.academia.edu/Documents/in/Magnesium?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71294" href="https://www.academia.edu/Documents/in/Kidney">Kidney</a>, <script data-card-contents-for-ri="71294" type="text/json">{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="90702" href="https://www.academia.edu/Documents/in/Ultrasonography">Ultrasonography</a><script data-card-contents-for-ri="90702" type="text/json">{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography?f_ri=160656","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30331449]'), work: {"id":30331449,"title":"Anatomic and metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease","created_at":"2016-12-08T07:18:07.675-08:00","url":"https://www.academia.edu/30331449/Anatomic_and_metabolic_risk_factors_for_nephrolithiasis_in_patients_with_autosomal_dominant_polycystic_kidney_disease?f_ri=160656","dom_id":"work_30331449","summary":null,"downloadable_attachments":[{"id":50785526,"asset_id":30331449,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":57813955,"first_name":"Ann","last_name":"Johnson","domain_name":"independent","page_name":"AnnJohnson25","display_name":"Ann Johnson","profile_url":"https://independent.academia.edu/AnnJohnson25?f_ri=160656","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=160656","nofollow":false},{"id":70902,"name":"Magnesium","url":"https://www.academia.edu/Documents/in/Magnesium?f_ri=160656","nofollow":false},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney?f_ri=160656","nofollow":false},{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography?f_ri=160656","nofollow":false},{"id":125564,"name":"Statistical Significance","url":"https://www.academia.edu/Documents/in/Statistical_Significance?f_ri=160656"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=160656"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656"},{"id":168891,"name":"Chemical Analysis","url":"https://www.academia.edu/Documents/in/Chemical_Analysis?f_ri=160656"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=160656"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=160656"},{"id":541785,"name":"Phosphates","url":"https://www.academia.edu/Documents/in/Phosphates?f_ri=160656"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=160656"},{"id":1423006,"name":"General Population","url":"https://www.academia.edu/Documents/in/General_Population?f_ri=160656"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4597194" data-work_id="4597194" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4597194/Comparative_lung_bioavailability_of_fluticasone_salmeterol_via_a_breath_actuated_spacer_and_conventional_plastic_spacers">Comparative lung bioavailability of fluticasone/salmeterol via a breath-actuated spacer and conventional plastic spacers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4597194" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex Synchro-Breathe (SB) device and an Evohaler pMDI (EH) device using adrenal suppression and early fall in serum potassium (K) as surrogates for respirable dose. Methods Seventeen healthy volunteers completed this randomised double-blind, double-dummy crossover study. Single doses of placebo/Seretide 250 (total dose ex valve fluticasone 2000 mcg/salmeterol 200 mcg) were administered via the devices. Overnight urinary cortisol/creatinine (OUCC) and serum K were measured at baseline and after each dose. Results Significant suppression of OUCC and K occurred from baseline with the SB, AP and VM but not with the EH devices. The geometric mean fold suppression (95% confidence interval, p) was: EH, 1.59 (0.80–3.14, p = 0.40); AP, 4.26 (3.01–6.02, p < 0.001); VM, 3.11 (1.99–4.78, p < 0. 001); SB, 3.29 (2.04–5.24, p < 0.001). For K, the arithmetic mean fall (mmol/l) (95% confidence interval; p) was: EH, −0.10 (−0.25–0.05, p = 0.18); AP, −0.23 (−0.41 to −0.04, p = 0.02); VM, −0.22 (−0.44 to −0.01, p = 0.04); SB, −0.28 (−0.42 to −0.13, p = 0.001). Conclusions The breath-actuated SB device was comparable to ‘out of the box’ small and large volume spacers and produced similar improvements in relative systemic lung bioavailability for fluticasone and salmeterol.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4597194" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c5bdcaedd1afa49bc22324c2ebe0de72" rel="nofollow" data-download="{"attachment_id":49770852,"asset_id":4597194,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49770852/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5777272" href="https://msw.academia.edu/ArunNair">Arun Nair</a><script data-card-contents-for-user="5777272" type="text/json">{"id":5777272,"first_name":"Arun","last_name":"Nair","domain_name":"msw","page_name":"ArunNair","display_name":"Arun Nair","profile_url":"https://msw.academia.edu/ArunNair?f_ri=160656","photo":"https://0.academia-photos.com/5777272/2489915/2892014/s65_arun.nair.jpg"}</script></span></span></li><li class="js-paper-rank-work_4597194 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4597194"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4597194, container: ".js-paper-rank-work_4597194", }); 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$(".js-view-count[data-work-id=4597194]").text(description); $(".js-view-count-work_4597194").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4597194").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4597194"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="58431" href="https://www.academia.edu/Documents/in/Cortisol">Cortisol</a>, <script data-card-contents-for-ri="58431" type="text/json">{"id":58431,"name":"Cortisol","url":"https://www.academia.edu/Documents/in/Cortisol?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="160656" href="https://www.academia.edu/Documents/in/Potassium">Potassium</a>, <script data-card-contents-for-ri="160656" type="text/json">{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="197297" href="https://www.academia.edu/Documents/in/Lung">Lung</a>, <script data-card-contents-for-ri="197297" type="text/json">{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=160656","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4597194]'), work: {"id":4597194,"title":"Comparative lung bioavailability of fluticasone/salmeterol via a breath-actuated spacer and conventional plastic spacers","created_at":"2013-09-26T11:07:50.971-07:00","url":"https://www.academia.edu/4597194/Comparative_lung_bioavailability_of_fluticasone_salmeterol_via_a_breath_actuated_spacer_and_conventional_plastic_spacers?f_ri=160656","dom_id":"work_4597194","summary":"Purpose This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex Synchro-Breathe (SB) device and an Evohaler pMDI (EH) device using adrenal suppression and early fall in serum potassium (K) as surrogates for respirable dose. Methods Seventeen healthy volunteers completed this randomised double-blind, double-dummy crossover study. Single doses of placebo/Seretide 250 (total dose ex valve fluticasone 2000 mcg/salmeterol 200 mcg) were administered via the devices. Overnight urinary cortisol/creatinine (OUCC) and serum K were measured at baseline and after each dose. Results Significant suppression of OUCC and K occurred from baseline with the SB, AP and VM but not with the EH devices. The geometric mean fold suppression (95% confidence interval, p) was: EH, 1.59 (0.80–3.14, p = 0.40); AP, 4.26 (3.01–6.02, p \u003c 0.001); VM, 3.11 (1.99–4.78, p \u003c 0. 001); SB, 3.29 (2.04–5.24, p \u003c 0.001). For K, the arithmetic mean fall (mmol/l) (95% confidence interval; p) was: EH, −0.10 (−0.25–0.05, p = 0.18); AP, −0.23 (−0.41 to −0.04, p = 0.02); VM, −0.22 (−0.44 to −0.01, p = 0.04); SB, −0.28 (−0.42 to −0.13, p = 0.001). Conclusions The breath-actuated SB device was comparable to ‘out of the box’ small and large volume spacers and produced similar improvements in relative systemic lung bioavailability for fluticasone and salmeterol.","downloadable_attachments":[{"id":49770852,"asset_id":4597194,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5777272,"first_name":"Arun","last_name":"Nair","domain_name":"msw","page_name":"ArunNair","display_name":"Arun Nair","profile_url":"https://msw.academia.edu/ArunNair?f_ri=160656","photo":"https://0.academia-photos.com/5777272/2489915/2892014/s65_arun.nair.jpg"}],"research_interests":[{"id":58431,"name":"Cortisol","url":"https://www.academia.edu/Documents/in/Cortisol?f_ri=160656","nofollow":false},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656","nofollow":false},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=160656","nofollow":false},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=160656","nofollow":false},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability?f_ri=160656"},{"id":1146830,"name":"Cross-Over Studies","url":"https://www.academia.edu/Documents/in/Cross-Over_Studies?f_ri=160656"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=160656"},{"id":1587858,"name":"Confidence Interval","url":"https://www.academia.edu/Documents/in/Confidence_Interval?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10016874" data-work_id="10016874" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10016874/NPK_farm_gate_nutrient_balances_in_dairy_farms_from_Northwest_Portugal">NPK farm-gate nutrient balances in dairy farms from Northwest Portugal</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10016874" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f8d41b6731ccf0441642f25c9f20ddd0" rel="nofollow" data-download="{"attachment_id":47568583,"asset_id":10016874,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47568583/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" 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data-has-card-for-ri="53108" href="https://www.academia.edu/Documents/in/Phosphorus">Phosphorus</a>, <script data-card-contents-for-ri="53108" type="text/json">{"id":53108,"name":"Phosphorus","url":"https://www.academia.edu/Documents/in/Phosphorus?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="77785" href="https://www.academia.edu/Documents/in/Nutrient_Management">Nutrient Management</a>, <script data-card-contents-for-ri="77785" type="text/json">{"id":77785,"name":"Nutrient Management","url":"https://www.academia.edu/Documents/in/Nutrient_Management?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="151091" href="https://www.academia.edu/Documents/in/Nitrogen">Nitrogen</a>, <script data-card-contents-for-ri="151091" type="text/json">{"id":151091,"name":"Nitrogen","url":"https://www.academia.edu/Documents/in/Nitrogen?f_ri=160656","nofollow":false}</script><a class="InlineList-item-text" 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href="https://www.academia.edu/22570890/Comparative_analysis_of_some_selected_macronutrients_of_soil_in_orange_orchard_and_degraded_forests_in_Chittagong_Hill_Tracts_Bangladesh">Comparative analysis of some selected macronutrients of soil in orange orchard and degraded forests in Chittagong Hill Tracts, Bangladesh</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Status of organic carbon (C), total nitrogen (N), available potassium (K), calcium (Ca) and phosphorus (P) in three different depths (0−5 cm, 5−15 cm and 15−30 cm) on two hill slopes of 35% and 55% in orange orchard cultivated by the Mro... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22570890" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Status of organic carbon (C), total nitrogen (N), available potassium (K), calcium (Ca) and phosphorus (P) in three different depths (0−5 cm, 5−15 cm and 15−30 cm) on two hill slopes of 35% and 55% in orange orchard cultivated by the Mro tribe of Chittagong Hill Tracts (CHTs) were evaluated and compared with those in degraded bush forests, through digging three profiles in each land use. The content of all the five nutrients was found to be higher in the soil of orange orchard than in the soil of forest. But the variation was not consistent for both the slopes. The content varied depth wise also, having the highest value in surface soil in case of both the land uses on both the slopes. A mean available K content was significantly higher in orange orchard than in forest on 55% slope, while it was lower on 35% slope. Surface soil contained the nutrients of K and Ca with the amount of 0.2905-mg·g -1 soil and 3.025-mg·g -1 soil respectively in the orchard, while 0.1934-mg·g -1 soil and ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22570890" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2ca23ca622c7ca65a8c7cc996fbdef7c" rel="nofollow" data-download="{"attachment_id":43180469,"asset_id":22570890,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43180469/download_file?st=MTczMzA1MzA1OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="19403629" href="https://ingenst.academia.edu/AbdulHalim">Abdul Halim</a><script data-card-contents-for-user="19403629" type="text/json">{"id":19403629,"first_name":"Abdul","last_name":"Halim","domain_name":"ingenst","page_name":"AbdulHalim","display_name":"Abdul Halim","profile_url":"https://ingenst.academia.edu/AbdulHalim?f_ri=160656","photo":"https://0.academia-photos.com/19403629/5401341/6163494/s65_abdul.halim.jpg_oh_db13d4ff5f98f80bf327d4fcbbf991d5_oe_54b12a34"}</script></span></span></li><li class="js-paper-rank-work_22570890 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22570890"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22570890, container: ".js-paper-rank-work_22570890", }); 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The content of all the five nutrients was found to be higher in the soil of orange orchard than in the soil of forest. But the variation was not consistent for both the slopes. The content varied depth wise also, having the highest value in surface soil in case of both the land uses on both the slopes. A mean available K content was significantly higher in orange orchard than in forest on 55% slope, while it was lower on 35% slope. Surface soil contained the nutrients of K and Ca with the amount of 0.2905-mg·g -1 soil and 3.025-mg·g -1 soil respectively in the orchard, while 0.1934-mg·g -1 soil and ...","downloadable_attachments":[{"id":43180469,"asset_id":22570890,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":19403629,"first_name":"Abdul","last_name":"Halim","domain_name":"ingenst","page_name":"AbdulHalim","display_name":"Abdul Halim","profile_url":"https://ingenst.academia.edu/AbdulHalim?f_ri=160656","photo":"https://0.academia-photos.com/19403629/5401341/6163494/s65_abdul.halim.jpg_oh_db13d4ff5f98f80bf327d4fcbbf991d5_oe_54b12a34"}],"research_interests":[{"id":1041,"name":"Forestry","url":"https://www.academia.edu/Documents/in/Forestry?f_ri=160656","nofollow":false},{"id":53108,"name":"Phosphorus","url":"https://www.academia.edu/Documents/in/Phosphorus?f_ri=160656","nofollow":false},{"id":67692,"name":"Orchard management","url":"https://www.academia.edu/Documents/in/Orchard_management?f_ri=160656","nofollow":false},{"id":72548,"name":"Soil Erosion","url":"https://www.academia.edu/Documents/in/Soil_Erosion?f_ri=160656","nofollow":false},{"id":86840,"name":"Chittagong Hill Tracts","url":"https://www.academia.edu/Documents/in/Chittagong_Hill_Tracts?f_ri=160656"},{"id":109291,"name":"Land Use","url":"https://www.academia.edu/Documents/in/Land_Use?f_ri=160656"},{"id":152553,"name":"Comparative Analysis","url":"https://www.academia.edu/Documents/in/Comparative_Analysis?f_ri=160656"},{"id":154923,"name":"Nutrient Content","url":"https://www.academia.edu/Documents/in/Nutrient_Content?f_ri=160656"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=160656"},{"id":585192,"name":"Organic carbon","url":"https://www.academia.edu/Documents/in/Organic_carbon?f_ri=160656"},{"id":781142,"name":"Degraded forest","url":"https://www.academia.edu/Documents/in/Degraded_forest?f_ri=160656"},{"id":825922,"name":"Physical Properties of Peat Soil","url":"https://www.academia.edu/Documents/in/Physical_Properties_of_Peat_Soil?f_ri=160656"},{"id":870762,"name":"Total Nitrogen","url":"https://www.academia.edu/Documents/in/Total_Nitrogen?f_ri=160656"},{"id":992161,"name":"Forest Soil Ecology","url":"https://www.academia.edu/Documents/in/Forest_Soil_Ecology?f_ri=160656"},{"id":1180430,"name":"Macronutrient of Soil","url":"https://www.academia.edu/Documents/in/Macronutrient_of_Soil?f_ri=160656"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18592824" data-work_id="18592824" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18592824/Toward_Artificial_Ion_Channels_A_Lipophilic_G_Quadruplex">Toward Artificial Ion Channels: A Lipophilic G-Quadruplex</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">... Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, and Dipartimento di Chimica Organica “A Mangini”, Universita di Bologna, Via S. Donato 15, I-40127, Bologna, Italy. J. Am. Chem. 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Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, and Dipartimento di Chimica Organica “A Mangini”, Universita di Bologna, Via S. Donato 15, I-40127, Bologna, Italy. J. Am. Chem. 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