CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: polycaprolactone (PCL)</title> <meta name="description" content="Search results for: polycaprolactone (PCL)"> <meta name="keywords" content="polycaprolactone (PCL)"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="polycaprolactone (PCL)" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="polycaprolactone (PCL)"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 47</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: polycaprolactone (PCL)</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">47</span> Biodegradability and Thermal Properties of Polycaprolactone/Starch Nanocomposite as a Biopolymer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emad%20A.%20Jaffar%20Al-Mulla">Emad A. Jaffar Al-Mulla</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, a biopolymer-based nanocomposite was successfully prepared through melt blending technique. Two biodegradable polymers, polycaprolactone and starch, environmental friendly and obtained from renewable, easily available raw materials, have been chosen. Fatty hydrazide, synthesized from palm oil, has been used as a surfactant to modify montmorillonite (natural clay) for preparation of polycaprolactone/starch nanocomposite. X-ray diffraction and transmission electron microscopy were used to characterize nanocomposite formation. Compatibility of the blend was improved by adding 3% weight modified clay. Higher biodegradability and thermal stability of nanocomopeite were also observed compared to those of the polycaprolactone/starch blend. This product will solve the problem of plastic waste, especially disposable packaging, and reduce the dependence on petroleum-based polymers and surfactants. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title="polycaprolactone">polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=starch" title=" starch"> starch</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable" title=" biodegradable"> biodegradable</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title=" nanocomposite"> nanocomposite</a> </p> <a href="https://publications.waset.org/abstracts/6713/biodegradability-and-thermal-properties-of-polycaprolactonestarch-nanocomposite-as-a-biopolymer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6713.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">46</span> Effect of Lemongrass Oil Containing Polycaprolactone Nanofibers on Biofilm Formation of Proteus mirabilis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gulcan%20Sahal">Gulcan Sahal</a>, <a href="https://publications.waset.org/abstracts/search?q=Behzad%20Nasseri"> Behzad Nasseri</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Akbar%20Ebrahimi"> Ali Akbar Ebrahimi</a>, <a href="https://publications.waset.org/abstracts/search?q=Isil%20Seyis%20Bilkay"> Isil Seyis Bilkay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Proteus mirabilis strains which are natural colonizers of healthy individuals’ gastrointestinal tract are also known as common causes of catheter-associated urinary tract infections. Nowadays, as a result of an increased resistance to various antimicrobial drugs, there has been a growing interest in natural products. Therefore, the aim of this study is to investigate biofilm formation of P. mirabilis strains on lemongrass oil containing polycaprolactone nanofibers. Polycaprolactone nanofibers with different lemongrass oil concentrations were successfully prepared by electrospinning and biofilm formation of P. mirabilis on these nanofibers were determined by ‘Crystal Violet Staining Assay’. According to our results, polycaprolactone nanofibers with some lemongrass oil concentrations, decreased biofilm formation of P. mirabilis and this effect increased in parallel with the increase in lemongrass oil concentration. Our results indicate that, polycaprolactone nanofibers with some concentrations of lemongrass oil may provide a treatment against catheter-associated urinary tract infections by means of causing an inhibition on biofilm formation of P. mirabilis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anti-biofilm" title="anti-biofilm">anti-biofilm</a>, <a href="https://publications.waset.org/abstracts/search?q=biofilm%20formation" title=" biofilm formation"> biofilm formation</a>, <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title=" essential oils"> essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=nanofibers" title=" nanofibers"> nanofibers</a>, <a href="https://publications.waset.org/abstracts/search?q=proteus%20mirabilis" title=" proteus mirabilis"> proteus mirabilis</a> </p> <a href="https://publications.waset.org/abstracts/55250/effect-of-lemongrass-oil-containing-polycaprolactone-nanofibers-on-biofilm-formation-of-proteus-mirabilis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55250.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">412</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">45</span> Chloroform-Formic Acid Solvent Systems for Nanofibrous Polycaprolactone Webs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Yalcin%20Enis">I. Yalcin Enis</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Vojtech"> J. Vojtech</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Gok%20Sadikoglu"> T. Gok Sadikoglu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, polycaprolactone (PCL) was dissolved in chloroform: ethanol solvent system at a concentration of 18 w/v %. 1, 2, 4, and 6 droplets of formic acid were added to the prepared 10ml PCL-chloroform:ethanol solutions separately. Fibrous webs were produced by electrospinning technique. Morphology of the webs was investigated by using scanning electron microscopy (SEM) whereas fiber diameters were measured by Image J Software System. The effect of formic acid addition to the mostly used chloroform solvent on fiber morphology was examined. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chloroform" title="chloroform">chloroform</a>, <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title=" electrospinning"> electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=formic%20acid%20polycaprolactone" title=" formic acid polycaprolactone"> formic acid polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=fiber" title=" fiber"> fiber</a> </p> <a href="https://publications.waset.org/abstracts/29749/chloroform-formic-acid-solvent-systems-for-nanofibrous-polycaprolactone-webs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29749.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">276</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">44</span> Investigating the Physical Properties of Polycaprolactone/Eucomis autumnalis Nanocellulose Composite</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dolly%20Selikane">Dolly Selikane</a>, <a href="https://publications.waset.org/abstracts/search?q=Thandi%20Gumede"> Thandi Gumede</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Among the commonly studied organic fillers for polycaprolactone (PCL), cellulose is the most promising. It is available in various particle sizes and sources, providing numerous options for finding a suitable match for PCL matrices. In this study, cellulose was extracted from the leaves of E. autumnalis to create a PCL/nanocellulose composite through melt blending. The prepared nanocellulose was blended with PCL at a weight ratio of 97/3, and the resulting composite was characterized by its thermal and mechanical properties. The results showed that the addition of nanocellulose to PCL improved its mechanical properties, with a maximum increase of 29% in tensile strength and 31% in Young's modulus. The SEM analysis confirmed the successful blending of PCL and nanocellulose. The findings of this study suggest that the nanocellulose from Eucomis autumnalis plant has the potential to improve the mechanical properties of PCL and could be used in biomedical and packaging applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title="polycaprolactone">polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plants" title=" medicinal plants"> medicinal plants</a>, <a href="https://publications.waset.org/abstracts/search?q=Eucomis%20autumnalis" title=" Eucomis autumnalis"> Eucomis autumnalis</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocellulose" title=" nanocellulose"> nanocellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=composite" title=" composite"> composite</a> </p> <a href="https://publications.waset.org/abstracts/165667/investigating-the-physical-properties-of-polycaprolactoneeucomis-autumnalis-nanocellulose-composite" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165667.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">124</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">43</span> Preparation of Nanocomposites Based on Biodegradable Polycaprolactone by Melt Mixture</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Amine%20Zenasni">Mohamed Amine Zenasni</a>, <a href="https://publications.waset.org/abstracts/search?q=Bahia%20Meroufel"> Bahia Meroufel</a>, <a href="https://publications.waset.org/abstracts/search?q=Andr%C3%A9%20Merlin"> André Merlin</a>, <a href="https://publications.waset.org/abstracts/search?q=Said%20Benfarhi"> Said Benfarhi</a>, <a href="https://publications.waset.org/abstracts/search?q=St%C3%A9phane%20Molina"> Stéphane Molina</a>, <a href="https://publications.waset.org/abstracts/search?q=B%C3%A9atrice%20George"> Béatrice George </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The introduction of nano-fillers into polymers field lead to the creation of the nano composites. This creation is starting up a new revolution into the world of materials. Nano composites are similar to traditional composite of a polymer blend and filler with at least one nano-scopic dimension. In our project, we worked with nano composites of biodegradable polymer: polycaprolactone, combined with nano-clay (Maghnite) and with different nano-organo-clays. These nano composites have been prepared by melt mixture method. The advantage of this polymer is its degradability and bio compatibility. A study of the relationship between development, micro structure and physico chemical properties of nano composites, clays modified with 3-aminopropyltriethoxysilane (APTES) and Hexadecyltriméthy ammonium bromide (CTAB) and untreated clays were made. Melt mixture method is most suitable methods to get a better dispersion named exfoliation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title="nanocomposite">nanocomposite</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable" title=" biodegradable"> biodegradable</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=maghnite" title=" maghnite"> maghnite</a>, <a href="https://publications.waset.org/abstracts/search?q=melt%20mixture" title=" melt mixture"> melt mixture</a>, <a href="https://publications.waset.org/abstracts/search?q=APTES" title=" APTES"> APTES</a>, <a href="https://publications.waset.org/abstracts/search?q=CTAB" title=" CTAB"> CTAB</a> </p> <a href="https://publications.waset.org/abstracts/18860/preparation-of-nanocomposites-based-on-biodegradable-polycaprolactone-by-melt-mixture" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18860.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">435</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">42</span> Characterization of Biodegradable Polycaprolactone Containing Titanium Dioxide Micro and Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emi%20Govor%C4%8Din%20Bajsi%C4%87a">Emi Govorčin Bajsića</a>, <a href="https://publications.waset.org/abstracts/search?q=Vesna%20Oceli%C4%87%20Bulatovi%C4%87"> Vesna Ocelić Bulatović</a>, <a href="https://publications.waset.org/abstracts/search?q=Miroslav%20Slouf"> Miroslav Slouf</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20%C5%A0itum"> Ana Šitum</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Composites based on a biodegradable polycaprolactone (PCL) containing 0.5, 1.0 and 2.0 wt % of titanium dioxide (TiO2) micro and nanoparticles were prepared by melt mixing and the effect of filler type and contents on the thermal properties, dynamic-mechanical behaviour and morphology were investigated. Measurements of storage modulus and loss modulus by dynamic mechanical analysis (DMA) showed better results for microfilled PCL/TiO2 composites than nanofilled composites, with the same filler content. DSC analysis showed that the Tg and Tc of micro and nanocomposites were slightly lower than those of neat PCL. The crystallinity of the PCL increased with the addition of TiO2 micro and nanoparticles; however, the c for the PCL was unchanged with micro TiO2 content. The thermal stability of PCL/TiO2 composites were characterized using thermogravimetric analysis (TGA). The initial weight loss (5 wt %) occurs at slightly higher temperature with micro and nano TiO2 addition and with increasing TiO2 content. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title="polycaprolactone">polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=titanium%20dioxide" title=" titanium dioxide"> titanium dioxide</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20properties" title=" thermal properties"> thermal properties</a>, <a href="https://publications.waset.org/abstracts/search?q=morphology" title=" morphology"> morphology</a> </p> <a href="https://publications.waset.org/abstracts/7940/characterization-of-biodegradable-polycaprolactone-containing-titanium-dioxide-micro-and-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7940.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">41</span> Preparation and Evaluation of Gelatin-Hyaluronic Acid-Polycaprolactone Membrane Containing 0.5 % Atorvastatin Loaded Nanostructured Lipid Carriers as a Nanocomposite Scaffold for Skin Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahsa%20Ahmadi">Mahsa Ahmadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehdi%20Mehdikhani-Nahrkhalaji"> Mehdi Mehdikhani-Nahrkhalaji</a>, <a href="https://publications.waset.org/abstracts/search?q=Jaleh%20Varshosaz"> Jaleh Varshosaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Shadi%20Farsaei"> Shadi Farsaei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gelatin and hyaluronic acid are commonly used in skin tissue engineering scaffolds, but because of their low mechanical properties and high biodegradation rate, adding a synthetic polymer such as polycaprolactone could improve the scaffold properties. Therefore, we developed a gelatin-hyaluronic acid-polycaprolactone scaffold, containing 0.5 % atorvastatin loaded nanostructured lipid carriers (NLCs) for skin tissue engineering. The atorvastatin loaded NLCs solution was prepared by solvent evaporation method and freeze drying process. Synthesized atorvastatin loaded NLCs was added to the gelatin and hyaluronic acid solution, and a membrane was fabricated with solvent evaporation method. Thereafter it was coated by a thin layer of polycaprolactone via spine coating set. The resulting scaffolds were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses. Moreover, mechanical properties, in vitro degradation in 7 days period, and in vitro drug release of scaffolds were also evaluated. SEM images showed the uniform distributed NLCs with an average size of 100 nm in the scaffold structure. Mechanical test indicated that the scaffold had a 70.08 Mpa tensile modulus which was twofold of tensile modulus of normal human skin. A Franz-cell diffusion test was performed to investigate the scaffold drug release in phosphate buffered saline (pH=7.4) medium. Results showed that 72% of atorvastatin was released during 5 days. In vitro degradation test demonstrated that the membrane was degradated approximately 97%. In conclusion, suitable physicochemical and biological properties of membrane indicated that the developed gelatin-hyaluronic acid-polycaprolactone nanocomposite scaffold containing 0.5 % atorvastatin loaded NLCs could be used as a good candidate for skin tissue engineering applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atorvastatin" title="atorvastatin">atorvastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=gelatin" title=" gelatin"> gelatin</a>, <a href="https://publications.waset.org/abstracts/search?q=hyaluronic%20acid" title=" hyaluronic acid"> hyaluronic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=nano%20lipid%20carriers%20%28NLCs%29" title=" nano lipid carriers (NLCs)"> nano lipid carriers (NLCs)</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20tissue%20engineering" title=" skin tissue engineering"> skin tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=solvent%20casting" title=" solvent casting"> solvent casting</a>, <a href="https://publications.waset.org/abstracts/search?q=solvent%20evaporation" title=" solvent evaporation"> solvent evaporation</a> </p> <a href="https://publications.waset.org/abstracts/75203/preparation-and-evaluation-of-gelatin-hyaluronic-acid-polycaprolactone-membrane-containing-05-atorvastatin-loaded-nanostructured-lipid-carriers-as-a-nanocomposite-scaffold-for-skin-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75203.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">252</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">40</span> Poly(Lactic Acid) Based Flexible Films</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fathilahbinti%20Ali">Fathilahbinti Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamarosliza%20Jamaluddin"> Jamarosliza Jamaluddin</a>, <a href="https://publications.waset.org/abstracts/search?q=Arun%20Kumar%20Upadhyay"> Arun Kumar Upadhyay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Poly(lactic acid) (PLA) is a biodegradable polymer which has good mechanical properties, however, its brittleness limits its usage especially in packaging materials. Therefore, in this work, PLA based polyurethane films were prepared by synthesizing with different types of isocyanates; methylene diisocyanate (MDI) and hexamethylene diisocyanates (HDI). For this purpose, PLA based polyurethane must have good strength and flexibility. Therefore, polycaprolactone which has better flexibility were prepared with PLA. An effective way to endow polylactic acid with toughness is through chain-extension reaction of the polylactic acid pre-polymer with polycaprolactone used as chain extender. Polyurethane prepared from MDI showed brittle behaviour, while, polyurethane prepared from HDI showed flexibility at same concentrations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymer" title="biodegradable polymer">biodegradable polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=flexible" title=" flexible"> flexible</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%28lactic%20acid%29" title=" poly(lactic acid)"> poly(lactic acid)</a>, <a href="https://publications.waset.org/abstracts/search?q=polyurethane" title=" polyurethane"> polyurethane</a> </p> <a href="https://publications.waset.org/abstracts/7819/polylactic-acid-based-flexible-films" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7819.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">352</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">39</span> Functional Yoghurt Enriched with Microencapsulated Olive Leaves Extract Powder Using Polycaprolactone via Double Emulsion/Solvent Evaporation Technique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tamer%20El-Messery">Tamer El-Messery</a>, <a href="https://publications.waset.org/abstracts/search?q=Teresa%20Sanchez-Moya"> Teresa Sanchez-Moya</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruben%20Lopez-Nicolas"> Ruben Lopez-Nicolas</a>, <a href="https://publications.waset.org/abstracts/search?q=Gaspar%20Ros"> Gaspar Ros</a>, <a href="https://publications.waset.org/abstracts/search?q=Esmat%20Aly"> Esmat Aly</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Olive leaves (OLs), the main by-product of the olive oil industry, have a considerable amount of phenolic compounds. The exploitation of these compounds represents the current trend in food processing. In this study, OLs polyphenols were microencapsulated with polycaprolactone (PCL) and utilized in formulating novel functional yoghurt. PCL-microcapsules were characterized by scanning electron microscopy, and Fourier transform infrared spectrometry analysis. Their total phenolic (TPC), total flavonoid (TFC) contents, and antioxidant activities (DPPH, FRAP, ABTS), and polyphenols bioaccessibility were measured after oral, gastric, and intestinal steps of in vitro digestion. The four yoghurt formulations (containing 0, 25, 50, and 75 mg of PCL-microsphere/100g yoghurt) were evaluated for their pH, acidity, syneresis viscosity, and color during storage. In vitro digestion significantly affected the phenolic composition in non-encapsulated extract while had a lower impact on encapsulated phenolics. Higher protection was provided for encapsulated OLs extract, and their higher release was observed at the intestinal phase. Yoghurt with PCL-microsphere had lower viscosity, syneresis, and color parameters, as compared to control yoghurt. Thus, OLs represent a valuable and cheap source of polyphenols which can be successfully applied, in microencapsulated form, to formulate functional yoghurt. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yoghurt%20quality%20attributes" title="yoghurt quality attributes">yoghurt quality attributes</a>, <a href="https://publications.waset.org/abstracts/search?q=olive%20leaves" title=" olive leaves"> olive leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20and%20flavonoids%20compounds" title=" phenolic and flavonoids compounds"> phenolic and flavonoids compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20as%20microencapsulant" title=" polycaprolactone as microencapsulant"> polycaprolactone as microencapsulant</a> </p> <a href="https://publications.waset.org/abstracts/135540/functional-yoghurt-enriched-with-microencapsulated-olive-leaves-extract-powder-using-polycaprolactone-via-double-emulsionsolvent-evaporation-technique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135540.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">38</span> Electrospun Alginate Nanofibers Containing Spirulina Extract Double-Layered with Polycaprolactone Nanofibers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seon%20Yeong%20Byeon">Seon Yeong Byeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Sung%20Shin"> Hwa Sung Shin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanofibrous sheets are of interest in the beauty industries due to the properties of moisturizing, adhesion to skin and delivery of nutrient materials. The benefit and function of the cosmetic products should not be considered without safety thus a non-toxic manufacturing process is ideal when fabricating the products. In this study, we have developed cosmetic patches consisting of alginate and Spirulina extract, a marine resource which has antibacterial and antioxidant effects, without addition of harmful cross-linkers. The patches obtained their structural stabilities by layer-upon-layer electrospinning of an alginate layer on a formerly spread polycaprolactone (PCL) layer instead of crosslinking method. The morphological characteristics, release of Spirulina extract, water absorption, skin adhesiveness and cytotoxicity of the double-layered patches were assessed. The image of scanning electron microscopy (SEM) showed that the addition of Spirulina extract has made the fiber diameter of alginate layers thinner. Impregnation of Spirulina extract increased their hydrophilicity, moisture absorption ability and skin adhesive ability. In addition, wetting the pre-dried patches resulted in releasing the Spirulina extract within 30 min. The patches were detected to have no cytotoxicity in the human keratinocyte cell-based MTT assay, but rather showed increased cell viability. All the results indicate the bioactive and hydro-adhesive double-layered patches have an excellent applicability to bioproducts for personal skin care in the trend of ‘A mask pack a day’. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alginate" title="alginate">alginate</a>, <a href="https://publications.waset.org/abstracts/search?q=cosmetic%20patch" title=" cosmetic patch"> cosmetic patch</a>, <a href="https://publications.waset.org/abstracts/search?q=electrospun%20nanofiber" title=" electrospun nanofiber"> electrospun nanofiber</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=Spirulina%20extract" title=" Spirulina extract"> Spirulina extract</a> </p> <a href="https://publications.waset.org/abstracts/75884/electrospun-alginate-nanofibers-containing-spirulina-extract-double-layered-with-polycaprolactone-nanofibers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75884.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">37</span> Polycaprolactone/Thermally Exfoliated Graphene Oxide Biocomposite Films: A Promising Moisture Absorption Behavior</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Neetu%20Malik">Neetu Malik</a>, <a href="https://publications.waset.org/abstracts/search?q=Sharad%20Shrivastava"> Sharad Shrivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=Subrata%20Bandhu%20Ghosh"> Subrata Bandhu Ghosh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biocomposite materials were fabricated using mixing biodegradable polymer polycaprolactone (PCL) and Thermally Exfoliated Graphene Oxide (TEGO) through solution casting. Various samples of biocomposite films were prepared by varying the TEGO wt% composition by 0.1%, 0.5%, 1% and 1.5%. Thereafter, the density and water absorption of the composites were investigated with respect to immersion time in water. The moisture absorption results show that with an increase in weight percentage (from 0.1 to wt 1.5%) of TEGO within the biopolymer films, the absorption value of bio-nanocomposite films reduced rapidly from 27.4% to 14.3%. The density of hybrid composites also increased with increase in weight percentage of TEGO. These results indicate that the optimized composition of constituents in composite membrane could effectively reduce the anhydrous conditions of bio-composite film. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thermally%20exfoliated%20graphene%20oxide" title="thermally exfoliated graphene oxide">thermally exfoliated graphene oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20absorption" title=" water absorption"> water absorption</a>, <a href="https://publications.waset.org/abstracts/search?q=density" title=" density"> density</a> </p> <a href="https://publications.waset.org/abstracts/82518/polycaprolactonethermally-exfoliated-graphene-oxide-biocomposite-films-a-promising-moisture-absorption-behavior" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82518.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> Polymerization of Epsilon-Caprolactone Using Lipase Enzyme for Medical Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sukanya%20Devi%20Ramachandran">Sukanya Devi Ramachandran</a>, <a href="https://publications.waset.org/abstracts/search?q=Vaishnavi%20Muralidharan"> Vaishnavi Muralidharan</a>, <a href="https://publications.waset.org/abstracts/search?q=Kavya%20Chandrasekaran"> Kavya Chandrasekaran</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polycaprolactone is polymer belonging to the polyester family that has noticeable characteristics of biodegradability and biocompatibility which is essential for medical applications. Polycaprolactone is produced by the ring opening polymerization of the monomer epsilon-Caprolactone (ε-CL) which is a closed ester, comprising of seven-membered ring. This process is normally catalysed by metallic components such as stannous octoate. It is difficult to remove the catalysts after the reaction, and they are also toxic to the human body. An alternate route of using enzymes as catalysts is being employed to reduce the toxicity. Lipase enzyme is a subclass of esterase that can easily attack the ester bonds of ε-CL. This research paper throws light on the extraction of lipase from germinating sunflower seeds and the activity of the biocatalyst in the polymerization of ε-CL. Germinating Sunflower seeds were crushed with fine sand in phosphate buffer of pH 6.5 into a fine paste which was centrifuged at 5000rpm for 10 minutes. The clear solution of the enzyme was tested for activity at various pH ranging from 5 to 7 and temperature ranging from 40oC to 70oC. The enzyme was active at pH6.0 and at 600C temperature. Polymerization of ε-CL was done using toluene as solvent with the catalysis of lipase enzyme, after which chloroform was added to terminate the reaction and was washed in cold methanol to obtain the polymer. The polymerization was done by varying the time from 72 hours to 6 days and tested for the molecular weight and the conversion of the monomer. The molecular weight obtained at 6 days is comparably higher. This method will be very effective, economical and eco-friendly to produce as the enzyme used can be regenerated as such at the end of the reaction and can be reused. The obtained polymers can be used for drug delivery and other medical applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lipase" title="lipase">lipase</a>, <a href="https://publications.waset.org/abstracts/search?q=monomer" title=" monomer"> monomer</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=polymerization" title=" polymerization"> polymerization</a> </p> <a href="https://publications.waset.org/abstracts/85799/polymerization-of-epsilon-caprolactone-using-lipase-enzyme-for-medical-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85799.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">296</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Influence of Organic Modifier Loading on Particle Dispersion of Biodegradable Polycaprolactone/Montmorillonite Nanocomposites </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=O.%20I.%20H.%20Dimitry">O. I. H. Dimitry</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20A.%20Mansour"> N. A. Mansour</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20L.%20G.%20Saad"> A. L. G. Saad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural sodium montmorillonite (NaMMT), Cloisite Na<sup>+</sup> and two organophilic montmorillonites (OMMTs), Cloisites 20A and 15A were used. Polycaprolactone (PCL)/MMT composites containing 1, 3, 5, and 10 wt% of Cloisite Na<sup>+</sup> and PCL/OMMT nanocomposites containing 5 and 10 wt% of Cloisites 20A and 15A were prepared via solution intercalation technique to study the influence of organic modifier loading on particle dispersion of PCL/ NaMMT composites. Thermal stabilities of the obtained composites were characterized by thermal analysis using the thermogravimetric analyzer (TGA) which showed that in the presence of nitrogen flow the incorporation of 5 and 10 wt% of filler brings some decrease in PCL thermal stability in the sequence: Cloisite Na+>Cloisite 15A > Cloisite 20A, while in the presence of air flow these fillers scarcely influenced the thermoxidative stability of PCL by slightly accelerating the process. The interaction between PCL and silicate layers was studied by Fourier transform infrared (FTIR) spectroscopy which confirmed moderate interactions between nanometric silicate layers and PCL segments. The electrical conductivity (σ) which describes the ionic mobility of the systems was studied as a function of temperature and showed that σ of PCL was enhanced on increasing the modifier loading at filler content of 5 wt%, especially at higher temperatures in the sequence: Cloisite Na<sup>+</sup><Cloisite 20A<Cloisite 15A, and was then decreased to some extent with a further increase to 10 wt%. The activation energy E<sub>σ</sub> obtained from the dependency of σ on temperature using Arrhenius equation was found to be lowest for the nanocomposite containing 5 wt% of Cloisite 15A. The dispersed behavior of clay in PCL matrix was evaluated by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses which revealed partial intercalated structures in PCL/NaMMT composites and semi-intercalated/semi-exfoliated structures in PCL/OMMT nanocomposites containing 5 wt% of Cloisite 20A or Cloisite 15A. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electrical%20conductivity" title="electrical conductivity">electrical conductivity</a>, <a href="https://publications.waset.org/abstracts/search?q=montmorillonite" title=" montmorillonite"> montmorillonite</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title=" nanocomposite"> nanocomposite</a>, <a href="https://publications.waset.org/abstracts/search?q=organoclay" title=" organoclay"> organoclay</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a> </p> <a href="https://publications.waset.org/abstracts/35381/influence-of-organic-modifier-loading-on-particle-dispersion-of-biodegradable-polycaprolactonemontmorillonite-nanocomposites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35381.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">378</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> Determining the Electrospinning Parameters of Poly(ε-Caprolactone)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Kagan%20%20Keler">M. Kagan Keler</a>, <a href="https://publications.waset.org/abstracts/search?q=Sibel%20Daglilar"> Sibel Daglilar</a>, <a href="https://publications.waset.org/abstracts/search?q=Isil%20%20Kerti"> Isil Kerti</a>, <a href="https://publications.waset.org/abstracts/search?q=Oguzhan%20Gunduz"> Oguzhan Gunduz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Electrospinning is a versatile way to occur fibers at nano-scale and polycaprolactone is a biomedical material which has a wide usage in cartilage defects and tissue regeneration. PCL is biocompatible and durable material which can be used in bio-implants. Therefore, electrospinning process was chosen as a fabrication method to get PCL fibers in an effective way because of its significant adjustments. In this research study, electrospinning parameters was evaluated during the producing of polymer tissue scaffolds. Polycaprolactone’s molecular weight was 80.000 Da and was employed as a tissue material in the electrospinning process. PCL was decomposed in dimethylformamid(DMF) and chloroform(CF) with the weight ratio of 1:1. Different compositions (1%, 3%, 5%, 10% and 20 %) of PCL was prepared in the laboratory conditions. All solvents with different percentages of PCL have been taken into the syringe and loaded into the electrospinning system. In electrospinning dozens of trial were applied to get homogeneously uniform scaffold samples. Taylor cone which is crucial point for electrospinning characteristic was occurred and changed in different voltages up to the material compositions’ conductivity. While the PCL percentages were increasing in the electrospinning, structure started to arise with droplets, which was an expressive problem for tissue scaffold. The vertical and horizontal layouts were applied to produce non-woven structures at all. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title="tissue engineering">tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=artificial%20scaffold" title=" artificial scaffold"> artificial scaffold</a>, <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title=" electrospinning"> electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=biocomposites" title=" biocomposites"> biocomposites</a> </p> <a href="https://publications.waset.org/abstracts/68217/determining-the-electrospinning-parameters-of-polye-caprolactone" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68217.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">348</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Direct In-Situ Ring Opening Polymerization of E-caprolactone to Produce Biodegradable PCL/Montmorillonite Nanocomposites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amine%20Harrane">Amine Harrane</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20Belalia"> Mahmoud Belalia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> During the last decade, polymer layered silicate nanocomposites have received increasing attention from scientists and industrial researchers because they generally exhibit greatly improved mechanical, thermal, barrier and flame-retardant properties at low clay content in comparison with unfilled polymers or more conventional micro composites. Poly(ε-caprolactone) (PCL)-layered silicate nanocomposites have the advantage of adding biocompatibility and biodegradability to the traditional properties of nanocomposites. They can be prepared by in situ ring-opening polymerization of ε-caprolactone using a conventional initiator to induce polymerization in the presence of an organophilic clay, such as organomodified montmorillonite. Messersmith and Giannelis used montmorillonite exchanged with protonated 12-amino dodecanoic acid and Cr3+ exchanged fluorohectorite, a synthetic mica type of silicate. Sn-based catalysts such as tin (II) octoate and dibutyltin (IV) dimethoxide have been reported to efficiently promote the polymerization of ε-caprolactone in the presence of organomodified clays. In this work, we have used an alternative method to prepare PCL/montmorillonite nanocomposites. The cationic polymerization of ε-caprolactone was initiated directly by Maghnite-TOA, organomodified montmorillonite clay, to produce nanocomposites (Scheme 1). Resulted from nanocomposites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), force atomic microscopy (AFM) and thermogravimetry. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title="polycaprolactone">polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone%2Fclay%20nanocomposites" title=" polycaprolactone/clay nanocomposites"> polycaprolactone/clay nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradables%20nanocomposites" title=" biodegradables nanocomposites"> biodegradables nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=Maghnite" title=" Maghnite"> Maghnite</a>, <a href="https://publications.waset.org/abstracts/search?q=Insitu%20polymeriation" title=" Insitu polymeriation"> Insitu polymeriation</a> </p> <a href="https://publications.waset.org/abstracts/163797/direct-in-situ-ring-opening-polymerization-of-e-caprolactone-to-produce-biodegradable-pclmontmorillonite-nanocomposites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163797.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">78</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> Thermal and Mechanical Properties of Polycaprolactone-Soy Lecithin Modified Bentonite Nanocomposites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Danila%20Merino">Danila Merino</a>, <a href="https://publications.waset.org/abstracts/search?q=Leandro%20N.%20Ludue%C3%B1a"> Leandro N. Ludueña</a>, <a href="https://publications.waset.org/abstracts/search?q=Vera%20A.%20Alvarez"> Vera A. Alvarez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Clays are commonly used to reinforce polymeric materials. In order to modify them, long-chain quaternary-alkylammonium salts have been widely employed. However, the application of these clays in biological fields is limited by the toxicity and poor biocompatibility presented by these modifiers. Meanwhile, soy lecithin, acts as a natural biosurfactant and environment-friendly biomodifier. In this report, we analyse the effect of content of soy lecithin-modified bentonite on the properties of polycaprolactone (PCL) nanocomposites. Commercial grade PCL (CAPA FB 100) was supplied by Perstorp, with Mw = 100000 g/mol. Minarmco S.A. and Melar S.A supplied bentonite and soy lecithin, respectively. Clays with 18, 30 and 45 wt% of organic content were prepared by exchanging 4 g of Na-Bent with 1, 2 and 4 g of soy lecithin aqueous and acid solution (pH=1, with HCl) at 75ºC for 2 h. Then, they were washed and lyophilized for 72 h. Samples were labeled A, B and C. Nanocomposites with 1 and 2 wt.% of each clay were prepared by melt-intercalation followed by compression-moulding. An intensive Brabender type mixer with two counter-rotating roller rotors was used. Mixing temperature was 100 ºC; speed of rotation was 100 rpm. and mixing time was 10 min. Compression moulding was carried out in a hydraulic press under 75 Kg/mm2 for 10 minutes at 100 ºC. The thickness of the samples was about 1 mm. Thermal and mechanical properties were analysed. PCL nanocomposites with 1 and 2% of B presented the best mechanical properties. It was observed that an excessive organic content produced an increment on the rigidity of PCL, but caused a detrimental effect on the tensile strength and elongation at break of the nanocomposites. Thermogravimetrical analyses suggest that all reinforced samples have higher resistance to degradation than neat PCL. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemical%20modification" title="chemical modification">chemical modification</a>, <a href="https://publications.waset.org/abstracts/search?q=clay" title=" clay"> clay</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title=" nanocomposite"> nanocomposite</a>, <a href="https://publications.waset.org/abstracts/search?q=characterization" title=" characterization"> characterization</a> </p> <a href="https://publications.waset.org/abstracts/46768/thermal-and-mechanical-properties-of-polycaprolactone-soy-lecithin-modified-bentonite-nanocomposites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46768.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Characterization and Degradation of 3D Printed Polycaprolactone-Freeze Dried Bone Matrix Constructs for Use in Critical Sized Bone Defects</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Samantha%20Meyr">Samantha Meyr</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20Mirdamadi"> Eman Mirdamadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Martha%20Wang"> Martha Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Tao%20Lowe"> Tao Lowe</a>, <a href="https://publications.waset.org/abstracts/search?q=Ryan%20Smith"> Ryan Smith</a>, <a href="https://publications.waset.org/abstracts/search?q=Quinn%20Burke"> Quinn Burke</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Critical-sized bone defects (CSD) treatment options remain a major clinical orthopedic challenge. They are uniquely contoured diseased or damaged bones and can be defined as those that will not heal spontaneously and require surgical intervention. Autografts are the current gold standard CSD treatment, which are histocompatible and provoke a minimal immunogenic response; however, they can cause donor site morbidity and will not suffice for the size required for replacement. As an alternative to traditional surgical methods, bone tissue engineering will be implemented via 3D printing methods. A freeze-dried bone matrix (FDBM) is a type of graft material available but will only function as desired when in the presence of bone growth factors. Polycaprolactone (PCL) is a known biodegradable material with good biocompatibility that has been proven manageable in 3D printing as a medical device. A 3D-extrusion printing strategy is introduced to print these materials into scaffolds for bone grafting purposes, which could be more accessible and rapid than the current standard. Mechanical, thermal, cytotoxic, and physical properties were investigated throughout a degradation period of 6 months using fibroblasts and dental pulp stem cells. PCL-FDBM scaffolds were successfully printed with high print fidelity in their respective pore sizes and allograft content. Additionally, we have created a method for evaluating PCL using differential scanning calorimetry (DSC) and have evaluated PCL degradation over roughly 6 months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=bone%20tissue%20engineering" title=" bone tissue engineering"> bone tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=degradation" title=" degradation"> degradation</a>, <a href="https://publications.waset.org/abstracts/search?q=scaffolds" title=" scaffolds"> scaffolds</a> </p> <a href="https://publications.waset.org/abstracts/173943/characterization-and-degradation-of-3d-printed-polycaprolactone-freeze-dried-bone-matrix-constructs-for-use-in-critical-sized-bone-defects" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173943.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">106</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> Increase of the Nanofiber Degradation Rate Using PCL-PEO and PCL-PVP as a Shell in the Electrospun Core-Shell Nanofibers Using the Needleless Blades</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Matej%20Buzgo">Matej Buzgo</a>, <a href="https://publications.waset.org/abstracts/search?q=Erico%20Himawan"> Erico Himawan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ksenija%20Ja%C5%A1Ina"> Ksenija JašIna</a>, <a href="https://publications.waset.org/abstracts/search?q=Aiva%20Simaite"> Aiva Simaite</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Electrospinning is a versatile and efficient technology for producing nanofibers for biomedical applications. One of the most common polymers used for the preparation of nanofibers for regenerative medicine and drug delivery applications is polycaprolactone (PCL). PCL is a biocompatible and bioabsorbable material that can be used to stimulate the regeneration of various tissues. It is also a common material used for the development of drug delivery systems by blending the polymer with small active molecules. However, for many drug delivery applications, e.g. cancer immunotherapy, PCL biodegradation rate that may exceed 9 months is too long, and faster nanofiber dissolution is needed. In this paper, we investigate the dissolution and small molecule release rates of PCL blends with two hydrophilic polymers: polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP). We show that adding hydrophilic polymer to the PCL reduces the water contact angle, increases the dissolution rate, and strengthens the interactions between the hydrophilic drug and polymer matrix that further sustain its release. Finally using this method, we were also able to increase the nanofiber degradation rate when PCL-PEO and PCL-PVP were used as a shell in the electrospun core-shell nanofibers and spread up the release of active proteins from their core. Electrospinning can be used for the preparation of the core-shell nanofibers, where active ingredients are encapsulated in the core and their release rate is regulated by the shell. However, such fibers are usually prepared by coaxial electrospinning that is an extremely low-throughput technique. An alternative is emulsion electrospinning that could be upscaled using needleless blades. In this work, we investigate the possibility of using emulsion electrospinning for encapsulation and sustained release of the growth factors for the development of the organotypic skin models. The core-shell nanofibers were prepared using the optimized formulation and the release rate of proteins from the fibers was investigated for 2 weeks – typical cell culture conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title="electrospinning">electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20%28PCL%29" title=" polycaprolactone (PCL)"> polycaprolactone (PCL)</a>, <a href="https://publications.waset.org/abstracts/search?q=polyethylene%20oxide%20%28PEO%29" title=" polyethylene oxide (PEO)"> polyethylene oxide (PEO)</a>, <a href="https://publications.waset.org/abstracts/search?q=polyvinylpyrrolidone%20%28PVP%29" title=" polyvinylpyrrolidone (PVP)"> polyvinylpyrrolidone (PVP)</a> </p> <a href="https://publications.waset.org/abstracts/138097/increase-of-the-nanofiber-degradation-rate-using-pcl-peo-and-pcl-pvp-as-a-shell-in-the-electrospun-core-shell-nanofibers-using-the-needleless-blades" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138097.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> Synthesis and Characterization of Polycaprolactone for the Delivery of Rifampicin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Evelyn%20Osehontue%20Uroro">Evelyn Osehontue Uroro</a>, <a href="https://publications.waset.org/abstracts/search?q=Richard%20Bright"> Richard Bright</a>, <a href="https://publications.waset.org/abstracts/search?q=Jing%20Yang%20Quek"> Jing Yang Quek</a>, <a href="https://publications.waset.org/abstracts/search?q=Krasimir%20Vasilev"> Krasimir Vasilev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bacterial infections have been a challenge both in the public and private sectors. The colonization of bacteria often occurs in medical devices such as catheters, heart valves, respirators, and orthopaedic implants. When biomedical devices are inserted into patients, the deposition of macromolecules such as fibrinogen and immunoglobin on their surfaces makes it easier for them to be prone to bacteria colonization leading to the formation of biofilms. The formation of biofilms on medical devices has led to a series of device-related infections which are usually difficult to eradicate and sometimes cause the death of patients. These infections require surgical replacements along with prolonged antibiotic therapy, which would incur additional health costs. It is, therefore, necessary to prevent device-related infections by inhibiting the formation of biofilms using intelligent technology. Antibiotic resistance of bacteria is also a major threat due to overuse. Different antimicrobial agents have been applied to microbial infections. They include conventional antibiotics like rifampicin. The use of conventional antibiotics like rifampicin has raised concerns as some have been found to have hepatic and nephrotoxic effects due to overuse. Hence, there is also a need for proper delivery of these antibiotics. Different techniques have been developed to encapsulate and slowly release antimicrobial agents, thus reducing host cytotoxicity. Examples of delivery systems are solid lipid nanoparticles, hydrogels, micelles, and polymeric nanoparticles. The different ways by which drugs are released from polymeric nanoparticles include diffusion-based release, elution-based release, and chemical/stimuli-responsive release. Polymeric nanoparticles have gained a lot of research interest as they are basically made from biodegradable polymers. An example of such a biodegradable polymer is polycaprolactone (PCL). PCL degrades slowly by hydrolysis but is often sensitive and responsive to stimuli like enzymes to release encapsulants for antimicrobial therapy. This study presents the synthesis of PCL nanoparticles loaded with rifampicin and the on-demand release of rifampicin for treating staphylococcus aureus infections. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=enzyme" title="enzyme">enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=Staphylococcus%20aureus" title=" Staphylococcus aureus"> Staphylococcus aureus</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=rifampicin" title=" rifampicin"> rifampicin</a> </p> <a href="https://publications.waset.org/abstracts/163027/synthesis-and-characterization-of-polycaprolactone-for-the-delivery-of-rifampicin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163027.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">126</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Development of Soft 3D Printing Materials for Textile Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chi-Chung%20Marven%20Chick">Chi-Chung Marven Chick</a>, <a href="https://publications.waset.org/abstracts/search?q=Chu-Po%20Ho"> Chu-Po Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=Sau-Chuen%20Joe%20Au"> Sau-Chuen Joe Au</a>, <a href="https://publications.waset.org/abstracts/search?q=Wing-Fai%20Sidney%20Wong"> Wing-Fai Sidney Wong</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi-Wai%20Kan"> Chi-Wai Kan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, 3D printing becomes popular process for manufacturing, especially has special attention in textile applications. However, there are various types of 3D printing materials, including plastic, resin, rubber, ceramics, gold, platinum, silver, iron, titanium but not all these materials are suitable for textile application. Generally speaking, 3D printing of textile mainly uses thermoplastic polymers such as acrylonitrile butadiene styrene (ABS), polylactide (PLA), polycaprolactone (PCL), thermoplastic polyurethane (TPU), polyethylene terephthalate glycol-modified (PETG), polystyrene (PS), polypropylene (PP). Due to the characteristics of the polymers, 3D printed textiles usually have low air permeability and poor comfortable. Therefore, in this paper, we will review the possible materials suitable for textile application with desired physical and mechanical properties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing%20materials" title=" 3D printing materials"> 3D printing materials</a>, <a href="https://publications.waset.org/abstracts/search?q=textile" title=" textile"> textile</a>, <a href="https://publications.waset.org/abstracts/search?q=properties" title=" properties"> properties</a> </p> <a href="https://publications.waset.org/abstracts/184118/development-of-soft-3d-printing-materials-for-textile-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184118.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">63</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Microfluidic Synthesis of Chlorophyll Extraction–Loaded PCL Composite Microparticles Developed as Health Food</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ching-Ju%20Hsiao">Ching-Ju Hsiao</a>, <a href="https://publications.waset.org/abstracts/search?q=Mao-Chen%20Huang"> Mao-Chen Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Pei-Fan%20Chen"> Pei-Fan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruo-Yun%20Chung"> Ruo-Yun Chung</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiun-Hua%20Chou"> Jiun-Hua Chou</a>, <a href="https://publications.waset.org/abstracts/search?q=Chih-Hui%20Yang"> Chih-Hui Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Keng-Shiang%20Huang"> Keng-Shiang Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jei-Fu%20Shaw"> Jei-Fu Shaw</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chlorophyll has many benefits for human body. It is known to improve the health of the circulatory, digestive, immune and detoxification systems of the body. However, Chl can’t be preserved at the environment of high temperature and light exposure for a long time due to it is chemical structure is easily degradable. This characteristic causes that human body is difficult to absorb Chl effective components. In order to solve this problem, we utilize polycaprolactone (PCL) polymer encapsulation technology to increase the stability of Chl. In particular, we also established a microfluidic platform provide the control of composite beads diameter. The new composite beads is potential to be a health food. Result show that Chl effective components via the microfludic platform can be encapsulated effectively and still preserve its effective components. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chlorophyll" title="chlorophyll">chlorophyll</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PVA" title=" PVA"> PVA</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidic" title=" microfluidic"> microfluidic</a> </p> <a href="https://publications.waset.org/abstracts/26797/microfluidic-synthesis-of-chlorophyll-extraction-loaded-pcl-composite-microparticles-developed-as-health-food" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26797.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">555</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Chemical Functionalization of Graphene Oxide for Improving Mechanical and Thermal Properties of Polyurethane Composites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Qifei%20Jing">Qifei Jing</a>, <a href="https://publications.waset.org/abstracts/search?q=Vadim%20V.%20Silberschmidt"> Vadim V. Silberschmidt</a>, <a href="https://publications.waset.org/abstracts/search?q=Lin%20Li"> Lin Li</a>, <a href="https://publications.waset.org/abstracts/search?q=ZhiLi%20Dong"> ZhiLi Dong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Graphene oxide (GO) was chemically functionalized to prepare polyurethane (PU) composites with improved mechanical and thermal properties. In order to achieve a well exfoliated and stable GO suspension in an organic solvent (dimethylformamide, DMF), 4, 4′- methylenebis(phenyl isocyanate) and polycaprolactone diol, which were the two monomers for synthesizing PU, were selectively used to functionalize GO. The obtained functionalized GO (FGO) could form homogeneous dispersions in DMF solvent and the PU matrix, as well as provide a good compatibility with the PU matrix. The most efficient improvement of mechanical properties was achieved when 0.4 wt% FGO was added into the PU matrix, showing increases in the tensile stress, elongation at break and toughness by 34.2%, 27.6% and 64.5%, respectively, compared with those of PU. Regarding the thermal stability, PU filled with 1 wt% FGO showed the largest extent of improvement with T2% and T50% (the temperatures at which 2% and 50% weight-loss happened) 16 °C and 21 °C higher than those of PU, respectively. The significant improvement in both mechanical properties and thermal stability of FGO/PU composites should be attributed to the homogeneous dispersion of FGO in the PU matrix and strong interfacial interaction between them. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=composite" title="composite">composite</a>, <a href="https://publications.waset.org/abstracts/search?q=dispersion" title=" dispersion"> dispersion</a>, <a href="https://publications.waset.org/abstracts/search?q=graphene%20oxide" title=" graphene oxide"> graphene oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=polyurethane" title=" polyurethane"> polyurethane</a> </p> <a href="https://publications.waset.org/abstracts/38464/chemical-functionalization-of-graphene-oxide-for-improving-mechanical-and-thermal-properties-of-polyurethane-composites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38464.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">263</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> 3D Printing of Polycaprolactone Scaffold with Multiscale Porosity Via Incorporation of Sacrificial Sucrose Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mikaela%20Kutrolli">Mikaela Kutrolli</a>, <a href="https://publications.waset.org/abstracts/search?q=Noah%20S.%20Pereira"> Noah S. Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Vanessa%20Scanlon"> Vanessa Scanlon</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamadmahdi%20Samandari"> Mohamadmahdi Samandari</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Tamayol"> Ali Tamayol</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bone tissue engineering has drawn significant attention and various biomaterials have been tested. Polymers such as polycaprolactone (PCL) offer excellent biocompatibility, reasonable mechanical properties, and biodegradability. However, PCL scaffolds suffer a critical drawback: a lack of micro/mesoporosity, affecting cell attachment, tissue integration, and mineralization. It also results in a slow degradation rate. While 3D-printing has addressed the issue of macroporosity through CAD-guided fabrication, PCL scaffolds still exhibit poor smaller-scale porosity. To overcome this, we generated composites of PCL, hydroxyapatite (HA), and powdered sucrose (PS). The latter serves as a sacrificial material to generate porous particles after sucrose dissolution. Additionally, we have incorporated dexamethasone (DEX) to boost the PCL osteogenic properties. The resulting scaffolds maintain controlled macroporosity from the lattice print structure but also develop micro/mesoporosity within PCL fibers when exposed to aqueous environments. The study involved mixing PS into solvent-dissolved PCL in different weight ratios of PS to PCL (70:30, 50:50, and 30:70 wt%). The resulting composite was used for 3D printing of scaffolds at room temperature. Printability was optimized by adjusting pressure, speed, and layer height through filament collapse and fusion test. Enzymatic degradation, porogen leaching, and DEX release profiles were characterized. Physical properties were assessed using wettability, SEM, and micro-CT to quantify the porosity (percentage, pore size, and interconnectivity). Raman spectroscopy was used to verify the absence of sugar after leaching. Mechanical characteristics were evaluated via compression testing before and after porogen leaching. Bone marrow stromal cells (BMSCs) behavior in the printed scaffolds was studied by assessing viability, metabolic activity, osteo-differentiation, and mineralization. The scaffolds with a 70% sugar concentration exhibited superior printability and reached the highest porosity of 80%, but performed poorly during mechanical testing. A 50% PS concentration demonstrated a 70% porosity, with an average pore size of 25 µm, favoring cell attachment. No trace of sucrose was found in Raman after leaching the sugar for 8 hours. Water contact angle results show improved hydrophilicity as the sugar concentration increased, making the scaffolds more conductive to cell adhesion. The behavior of bone marrow stromal cells (BMSCs) showed positive viability and proliferation results with an increasing trend of mineralization and osteo-differentiation as the sucrose concentration increased. The addition of HA and DEX also promoted mineralization and osteo-differentiation in the cultures. The integration of PS as porogen at a concentration of 50%wt within PCL scaffolds presents a promising approach to address the poor cell attachment and tissue integration issues of PCL in bone tissue engineering. The method allows for the fabrication of scaffolds with tunable porosity and mechanical properties, suitable for various applications. The addition of HA and DEX further enhanced the scaffolds. Future studies will apply the scaffolds in an in-vivo model to thoroughly investigate their performance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone" title="bone">bone</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title=" 3D printing"> 3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a> </p> <a href="https://publications.waset.org/abstracts/182711/3d-printing-of-polycaprolactone-scaffold-with-multiscale-porosity-via-incorporation-of-sacrificial-sucrose-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182711.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">58</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> 3D Printing of Cold Atmospheric Plasma Treated Poly(ɛ-Caprolactone) for Bone Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dong%20Nyoung%20Heo">Dong Nyoung Heo</a>, <a href="https://publications.waset.org/abstracts/search?q=Il%20Keun%20Kwon"> Il Keun Kwon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Three-dimensional (3D) technology is a promising method for bone tissue engineering. In order to enhance bone tissue regeneration, it is important to have ideal 3D constructs with biomimetic mechanical strength, structure interconnectivity, roughened surface, and the presence of chemical functionality. In this respect, a 3D printing system combined with cold atmospheric plasma (CAP) was developed to fabricate a 3D construct that has a rough surface with polar functional chemical groups. The CAP-etching process leads to oxidation of chemical groups existing on the polycaprolactone (PCL) surface without conformational change. The surface morphology, chemical composition, mean roughness of the CAP-treated PCL surfaces were evaluated. 3D printed constructs composed of CAP-treated PCL showed an effective increment in the hydrophilicity and roughness of the PCL surface. Also, an in vitro study revealed that CAP-treated 3D PCL constructs had higher cellular behaviors such as cell adhesion, cell proliferation, and osteogenic differentiation. Therefore, a 3D printing system with CAP can be a highly useful fabrication method for bone tissue regeneration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20tissue%20engineering" title="bone tissue engineering">bone tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20atmospheric%20plasma" title=" cold atmospheric plasma"> cold atmospheric plasma</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title=" 3D printing"> 3D printing</a> </p> <a href="https://publications.waset.org/abstracts/126200/3d-printing-of-cold-atmospheric-plasma-treated-poly-caprolactone-for-bone-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/126200.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">114</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> Crystal Nucleation in 3D Printed Polymer Scaffolds in Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amani%20Alotaibi">Amani Alotaibi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> 3D printing has emerged as a pivotal technique for scaffold development, particularly in the field of bone tissue regeneration, due to its ability to customize scaffolds to fit complex geometries of bone defects. Among the various methods available, fused deposition modeling (FDM) is particularly promising as it avoids the use of solvents or toxic chemicals during fabrication. This study investigates the effects of three key parameters, extrusion temperature, screw rotational speed, and deposition speed, on the crystallization and mechanical properties of polycaprolactone (PCL) scaffolds. Three extrusion temperatures (70°C, 80°C, and 90°C), three screw speeds (10 RPM, 15 RPM, and 20 RPM), and three deposition speeds (8 mm/s, 10 mm/s, and 12 mm/s) were evaluated. The scaffolds were characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC), and tensile testing to assess changes in crystallinity and mechanical properties. Additionally, the scaffolds were analyzed for crystal size and biocompatibility. The results demonstrated that increasing the extrusion temperature to 80°C, combined with a screw speed of 15 RPM and a deposition speed of 10 mm/s, significantly improved the crystallinity, compressive modulus, and thermal resistance of the PCL scaffolds. These findings suggest that by fine-tuning basic 3D printing parameters, it is possible to modulate the structural and mechanical properties of the scaffold, thereby enhancing its suitability for bone tissue regeneration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer" title=" polymer"> polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=scaffolds" title=" scaffolds"> scaffolds</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=crystallization" title=" crystallization"> crystallization</a> </p> <a href="https://publications.waset.org/abstracts/194998/crystal-nucleation-in-3d-printed-polymer-scaffolds-in-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/194998.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Process Optimization of Electrospun Fish Sarcoplasmic Protein Based Nanofibers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sena%20Su">Sena Su</a>, <a href="https://publications.waset.org/abstracts/search?q=Burak%20Ozbek"> Burak Ozbek</a>, <a href="https://publications.waset.org/abstracts/search?q=Yesim%20M.%20Sahin"> Yesim M. Sahin</a>, <a href="https://publications.waset.org/abstracts/search?q=Sevil%20Yucel"> Sevil Yucel</a>, <a href="https://publications.waset.org/abstracts/search?q=Dilek%20Kazan"> Dilek Kazan</a>, <a href="https://publications.waset.org/abstracts/search?q=Faik%20N.%20Oktar"> Faik N. Oktar</a>, <a href="https://publications.waset.org/abstracts/search?q=Nazmi%20Ekren"> Nazmi Ekren</a>, <a href="https://publications.waset.org/abstracts/search?q=Oguzhan%20Gunduz"> Oguzhan Gunduz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, protein, lipid or polysaccharide-based polymers have been used in order to develop biodegradable materials and their chemical nature determines the physical properties of the resulting films. Among these polymers, proteins from different sources have been extensively employed because of their relative abundance, film forming ability, and nutritional qualities. In this study, the biodegradable composite nanofiber films based on fish sarcoplasmic protein (FSP) were prepared via electrospinning technique. Biodegradable polycaprolactone (PCL) was blended with the FSP to obtain hybrid FSP/PCL nanofiber mats with desirable physical properties. Mixture solutions of FSP and PCL were produced at different concentrations and their density, viscosity, electrical conductivity and surface tension were measured. Mechanical properties of electrospun nanofibers were evaluated. Morphology of composite nanofibers was observed using scanning electron microscopy (SEM). Moreover, Fourier transform infrared spectrometer (FTIR) studies were used for analysis chemical composition of composite nanofibers. This study revealed that the FSP based nanofibers have the potential to be used for different applications such as biodegradable packaging, drug delivery, and wound dressing, etc. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=edible%20film" title="edible film">edible film</a>, <a href="https://publications.waset.org/abstracts/search?q=electrospinning" title=" electrospinning"> electrospinning</a>, <a href="https://publications.waset.org/abstracts/search?q=fish%20sarcoplasmic%20protein" title=" fish sarcoplasmic protein"> fish sarcoplasmic protein</a>, <a href="https://publications.waset.org/abstracts/search?q=nanofiber" title=" nanofiber"> nanofiber</a> </p> <a href="https://publications.waset.org/abstracts/68672/process-optimization-of-electrospun-fish-sarcoplasmic-protein-based-nanofibers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68672.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">297</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Development of Chitosan/Dextran Gelatin Methacrylate Core/Shell 3D Scaffolds and Protein/Polycaprolactone Melt Electrowriting Meshes for Tissue Regeneration Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20D.%20Cabral">J. D. Cabral</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Murray"> E. Murray</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Turner"> P. Turner</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Hewitt"> E. Hewitt</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Ali"> A. Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20McConnell"> M. McConnell</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Worldwide demand for organ replacement and tissue regeneration is progressively increasing. Three-dimensional (3D) bioprinting, where a physical construct is produced using computer-aided design, is a promising tool to advance the tissue engineering and regenerative medicine fields. In this paper we describe two different approaches to developing 3D bioprinted constructs for use in tissue regeneration. Bioink development is critical in achieving the 3D biofabrication of functional, regenerative tissues. Hydrogels, cross-linked macromolecules that absorb large amounts of water, have received widespread interest as bioinks due to their relevant soft tissue mechanics, biocompatibility, and tunability. In turn, not only is bioink optimisation crucial, but the creation of vascularized tissues remains a key challenge for the successful fabrication of thicker, more clinically relevant bioengineered tissues. Among the various methodologies, cell-laden hydrogels are regarded as a favorable approach; and when combined with novel core/shell 3D bioprinting technology, an innovative strategy towards creating new vessel-like structures. In this work, we investigate this cell-based approach by using human umbilical endothelial cells (HUVECs) entrapped in a viscoelastic chitosan/dextran (CD)-based core hydrogel, printed simulataneously along with a gelatin methacrylate (GelMA) shell. We have expanded beyond our previously reported FDA approved, commercialised, post-surgical CD hydrogel, Chitogel®, by functionalizing it with cell adhesion and proteolytic peptides in order to promote bone marrow-derived mesenchymal stem cell (immortalized BMSC cell line, hTERT) and HUVECs growth. The biocompatibility and biodegradability of these cell lines in a 3D bioprinted construct is demonstrated. Our studies show that particular peptide combinations crosslinked within the CD hydrogel was found to increase in vitro growth of BMSCs and HUVECs by more than two-fold. These gels were then used as a core bioink combined with the more mechanically robust, UV irradiated GelMA shell bioink, to create 3D regenerative, vessel-like scaffolds with high print fidelity. As well, microporous MEW scaffolds made from milk proteins blended with PCL were found to show promising bioactivity, exhibiting a significant increase in keratinocyte (HaCaTs) and fibroblast (normal human dermal fibroblasts, NhDFs) cell migration and proliferation when compared to PCL only scaffolds. In conclusion, our studies indicate that a peptide functionalized CD hydrogel bioink reinforced with a GelMA shell is biocompatible, biodegradable, and an appropriate cell delivery vehicle in the creation of regenerative 3D constructs. In addition, a novel 3D printing technique, melt electrowriting (MEW), which allows fabrication of micrometer fibre meshes, was used to 3D print polycaprolactone (PCL) and bioactive milk protein, lactorferrin (LF) and whey protein (WP), blended scaffolds for potential skin regeneration applications. MEW milk protein/PCL scaffolds exhibited high porosity characteristics, low overall biodegradation, and rapid protein release. Human fibroblasts and keratinocyte cells were seeded on to the scaffolds. Scaffolds containing high concentrations of LF and combined proteins (LF+WP) showed improved cell viability over time as compared to PCL only scaffolds. This research highlights two scaffolds made using two different 3D printing techniques using a combination of both natural and synthetic biomaterial components in order to create regenerative constructs as potential chronic wound treatments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomaterials" title="biomaterials">biomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogels" title=" hydrogels"> hydrogels</a>, <a href="https://publications.waset.org/abstracts/search?q=regenerative%20medicine" title=" regenerative medicine"> regenerative medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20bioprinting" title=" 3D bioprinting"> 3D bioprinting</a> </p> <a href="https://publications.waset.org/abstracts/98096/development-of-chitosandextran-gelatin-methacrylate-coreshell-3d-scaffolds-and-proteinpolycaprolactone-melt-electrowriting-meshes-for-tissue-regeneration-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98096.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> The Effect of Surface Modified Nano-Hydroxyapatite Incorporation into Polymethylmethacrylate Cement on Biocompatibility and Mechanical Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yu-Shan%20Wu">Yu-Shan Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Po-Liang%20Lai"> Po-Liang Lai</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Poly(methylmethacrylate)(PMMA) is the most frequently used bone void filler for vertebral augmentation in osteoporotic fracture. PMMA bone cement not only exhibits strong mechanical properties but also can fabricate according to the shape of bone defect. However, the adhesion between the PMMA-based cement and the adjacent bone is usually weak and as PMMA bone cement is inherently bioinert. The combination of bioceramics and polymers as composites may increase cell adhesion and improve biocompatibility. The nano-hydroxyapatite(HAP) not only plays a significant role in maintaining the properties of the natural bone but also offers a favorable environment for osteoconduction, protein adhesion, and osteoblast proliferation. However, defects and cracks can form at the polymer/ceramics interface, resulting in uneven distribution of stress and subsequent inferior mechanical strength. Surface-modified HAP nano-crystals were prepared by chemically grafting poly(ε-caprolactone)(PCL) on surface-modified nano-HAP surface to increase the affinity of polymer/ceramic phases .Thus, incorporation of surface-modified nano-hydroxyapatite (EC-HAP) may not only improve the interfacial adhesion between cement and bone and between nanoparticles and cement, but also increase biocompatibility. In this research, PMMA mixing with 0, 5, 10, 15, 20, 25 and 30 wt% EC-HAP were examined. MC3T3-E1 cells were used for the biological evaluation of the response to the cements in vitro. Morphology was observed using scanning electron microscopy (SEM). Mechanical properties of HAP/PMMA and EC-HAP/PMMA cement were investigated by compression test. Surface wettability of the cements was measured by contact angles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20cement" title="bone cement">bone cement</a>, <a href="https://publications.waset.org/abstracts/search?q=biocompatibility" title=" biocompatibility"> biocompatibility</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-hydroxyapatite" title=" nano-hydroxyapatite"> nano-hydroxyapatite</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone" title=" polycaprolactone"> polycaprolactone</a>, <a href="https://publications.waset.org/abstracts/search?q=PMMA" title=" PMMA"> PMMA</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20grafting" title=" surface grafting"> surface grafting</a> </p> <a href="https://publications.waset.org/abstracts/45200/the-effect-of-surface-modified-nano-hydroxyapatite-incorporation-into-polymethylmethacrylate-cement-on-biocompatibility-and-mechanical-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45200.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Osteogenesis in Thermo-Sensitive Hydrogel Using Mesenchymal Stem Cell Derived from Human Turbinate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Reum%20Son">A. Reum Son</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Seon%20Kwon"> Jin Seon Kwon</a>, <a href="https://publications.waset.org/abstracts/search?q=Seung%20Hun%20Park"> Seung Hun Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Hai%20Bang%20Lee"> Hai Bang Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Moon%20Suk%20Kim"> Moon Suk Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> These days, stem cell therapy is focused on for promising source of treatment in clinical human disease. As a supporter of stem cells, in situ-forming hydrogels with growth factors and cells appear to be a promising approach in tissue engineering. To examine osteogenic differentiation of hTMSCs which is one of mesenchymal stem cells in vivo in an injectable hydrogel, we use a methoxy polyethylene glycol-polycaprolactone blockcopolymer (MPEG-PCL) solution with osteogenic factors. We synthesized MPEG-PCL hydrogel and measured viscosity to check sol-gel transition. In order to demonstrate osteogenic ability of hTMSCs, we conducted in vitro osteogenesis experiment. Then, to confirm the cell cytotoxicity, we performed WST-1 with hTMSCs and MPEG-PCL. As the result of in vitro experiment, we implanted cell and hydrogel mixture into animal model and checked degree of osteogenesis with histological analysis and amount of expression genes. Through these experimental data, MPEG-PCL hydrogel has sol-gel transition in temperature change and is biocompatible with stem cells. In histological analysis and gene expression, hTMSCs are very good source of osteogenesis with hydrogel and will use it to tissue engineering as important treatment method. hTMSCs could be a good adult stem cell source for usability of isolation and high proliferation. When hTMSCs are used as cell therapy method with in situ-formed hydrogel, they may provide various benefits like a noninvasive alternative for bone tissue engineering applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=injectable%20hydrogel" title="injectable hydrogel">injectable hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell" title=" stem cell"> stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=osteogenic%20differentiation" title=" osteogenic differentiation"> osteogenic differentiation</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a> </p> <a href="https://publications.waset.org/abstracts/9285/osteogenesis-in-thermo-sensitive-hydrogel-using-mesenchymal-stem-cell-derived-from-human-turbinate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9285.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">447</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Problems Associated with Fibre-Reinforced Composites Ultrasonically-Assisted Drilling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sikiru%20Oluwarotimi%20Ismail">Sikiru Oluwarotimi Ismail</a>, <a href="https://publications.waset.org/abstracts/search?q=Hom%20Nath%20Dhakal"> Hom Nath Dhakal</a>, <a href="https://publications.waset.org/abstracts/search?q=Anish%20Roy"> Anish Roy</a>, <a href="https://publications.waset.org/abstracts/search?q=Dong%20Wang"> Dong Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivan%20Popov"> Ivan Popov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ultrasonically-assisted drilling (UAD) is a non-traditional technique which involves the superimposition of a high frequency and low amplitude vibration, usually greater than 18kHz and less than 20µm respectively, on a drill bit along the feed direction. UAD has remarkable advantages over the conventional drilling (CD), especially the high drilling-force reduction. Force reduction improves the quality of the drilled holes, reduces power consumption rate and cost of production. Nevertheless, in addition to the setbacks of UAD including expensiveness of set-up, unpredicted results and chipping effects, this paper presents the problems of insignificant force reduction and poor surface quality during UAD of hemp fibre-reinforced composites (HFRCs), a natural composite, with polycaprolactone (PCL) matrix. The experimental results obtained depict that HFRCs/PCL samples have more burnt chip-materials attached on the drilled holes during UAD than CD. This effect produced a very high surface roughness (Ra), up to 13µm. In a bid to reduce these challenges, different drilling parameters (feed rates and cutting speeds, frequencies and amplitudes for UAD), conditions (dry machining and airflow cooling) and diameters of drill bits (3mm and 6mm of high speed steel), as well as HFRCs/PCL samples of various fibre aspect ratios, including 0 (neat), 19, 26, 30 and 38 have been used. However, the setbacks still persisted. Evidently, the benefits of UAD are not obtainable for the drilling of the HFRCs/PCL laminates. These problems occurred due to the 60 °C melting temperature of PCL, quite lower than 56-90.2 °C and 265–290.8 °C composite-tool interface temperature during CD and UAD respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=force%20reduction" title="force reduction">force reduction</a>, <a href="https://publications.waset.org/abstracts/search?q=hemp%20fibre-reinforced%20composites" title=" hemp fibre-reinforced composites"> hemp fibre-reinforced composites</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasonically-assisted%20drilling" title=" ultrasonically-assisted drilling"> ultrasonically-assisted drilling</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20quality" title=" surface quality"> surface quality</a> </p> <a href="https://publications.waset.org/abstracts/39473/problems-associated-with-fibre-reinforced-composites-ultrasonically-assisted-drilling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39473.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">438</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20%28PCL%29&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20%28PCL%29&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>