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<!doctype html> <html lang="en"> <head> <title>Cytotoxicity Assessment of Sea- Star Protein SIP-Young-6His | 92644</title> <meta name="keywords" content="Michel Leclerc, Sea star; Young protein; MCF7 Vertebrate cells; Doxorubicin; Invertebrates"/> <meta name="description" content="The objective of this project is to assess whether recombinant protein SIP-Young-6His, produced in HEK293, induces cell death in MCF-7 cells. To achieve..92644"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Journal of Clinical Chemistry and Laboratory Medicine"> <meta name="citation_title" content="Cytotoxicity Assessment of Sea- Star Protein SIP-Young-6His in MCF-7 Cells"> <meta name="citation_author" content="Michel Leclerc" /> <meta name="citation_year" content="2022"> <meta name="citation_volume" content="5"> <meta name="citation_issue" content="5"> <meta name="citation_doi" content="10.35248/ JCCLM.22.5.224"> <meta name="citation_issn" content="2736-6588"> <meta name="citation_publication_date" content="2022/06/30" /> <meta name="citation_firstpage" content="1"> <meta name="citation_lastpage" content="5"> <meta name="citation_abstract" content="The objective of this project is to assess whether recombinant protein SIP-Young-6His, produced in HEK293, induces cell death in MCF-7 cells. To achieve this, the metabolic activity is measured with the Cell Cytotoxicity Assay Kit (Abnova, Ref# KA4151) which contains a water-soluble dye that changes its absorption spectra upon cellular reduction. In first analysis it seems that sea star protein SIP-Young-6His have a weak cytotoxicity against MCF7 cells when compared to Doxorubicin activity against these same tumoral cells."> <meta name="citation_fulltext_html_url" content="https://www.longdom.org/open-access/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html"> <meta name="citation_pdf_url" content="https://www.longdom.org/open-access/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells.pdf"> <meta name="citation_abstract_html_url" content="https://www.longdom.org/abstract/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html"> <meta name="format-detection" content="telephone=no" /> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="ROBOTS" content="INDEX,FOLLOW" /> <meta name="googlebot" 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border-bottom:1px dotted #CCC;' title='Michel Leclerc'>Michel Leclerc</a>* </p> <p> <p>The objective of this project is to assess whether recombinant protein SIP-Young-6His, produced in HEK293, induces cell death in MCF-7 cells. To achieve this, the metabolic activity is measured with the Cell Cytotoxicity Assay Kit (Abnova, Ref# KA4151) which contains a water-soluble dye that changes its absorption spectra upon cellular reduction. In first analysis it seems that sea star protein SIP-Young-6His have a weak cytotoxicity against MCF7 cells when compared to Doxorubicin activity against these same tumoral cells. </p> <p class="mb-1 font-size-3 text-muted"> <b>Published Date: </b> 2022-06-30; <b>Received Date: </b>2022-05-30</p> <nav class="nav a-pl-0"> <a href="https://www.longdom.org/open-access/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html" title="Click here" class="nav-link text-danger"><img src="/assets/img/html.svg" alt="html" height="26"></a> <a href="https://www.longdom.org/open-access/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells.pdf" title="Click here" class="nav-link text-success"><img src="/assets/img/PDF_32.png" alt="pdf" height="26"></a> </nav> <div class="nav social-icons"> <a class="nav-link w-auto">Share this article</a> <a title="Click here" target="_blank" href="https://www.facebook.com/sharer.php?u=https://www.longdom.org/abstract/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://twitter.com/share?url=https://www.longdom.org/abstract/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.longdom.org/abstract/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Click here" target="_blank" href="https://plus.google.com/share?url=https://www.longdom.org/abstract/cytotoxicity-assessment-of-sea-star-protein-sipyoung6his-in-mcf7-cells-92644.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" href="https://www.longdom.org/feedback.html" title="Click here">Feedback</a></li> <li><a class="" href="https://www.longdom.org/careers.html" title="Click here">Careers</a></li> <li><a class="" href="https://www.longdom.org/privacy-policy.html" title="Click here">Privacy Policy</a></li> <li><a class="" href="https://www.longdom.org/terms-conditions.html" title="Click here">Terms & Conditions</a></li> <li><a class="" href="https://www.longdom.org/authors-reviewers-editors.html" title="Click here">Authors, Reviewers & Editors</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contact Longdom</h4> <p>Longdom Group SA<br> Avenue Roger Vandendriessche,<br> 18, 1150 Brussels, Belgium<br> Phone: +442038085340 <br><strong>Email:</strong> <a href="mailto:info@longdom.org" class="white" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connect</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Click here" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i> Facebook</a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Click here" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i> Linkedin</a> <a href="https://twitter.com/LongdomP" title="Click here" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i> Twitter</a> <a href="https://www.instagram.com/longdom_publisher/" title="Click here" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i> Instagram</a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Copyright © 2024 <a href="https://www.longdom.org/" title="Click here" class="white">Longdom Publishing</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script defer src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script defer src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script defer src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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