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Robust Manufacturing of Purer AAV Gene Therapy Vectors
<!doctype html> <html lang="en" data-bs-theme="auto"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="description" content=""> <meta name="author" content="Mark Otto, Jacob Thornton, and Bootstrap contributors"> <meta name="generator" content="Hugo 0.115.4"> <title>Robust Manufacturing of Purer AAV Gene Therapy Vectors</title> <link href="/webinardata/assets/css/bootstrap5-3.min.css" rel="stylesheet"> <!-- Custom styles for this template --> <!-- Custom styles for this template --> <link href="/webinardata/assets/css/custom.css" rel="stylesheet"> </head> <body> <div class="container"> <header class="blog-header lh-1"> <div class="row justify-content-between align-items-center"> <div class="col-md-6 col-sm-12 pt-1"> <div class="row"> <div class="col-md-6"> <a class="link-secondary" target="_blank" href="https://www.biaseparations.com/"> <img class="img-fluid" src="/uploads/webinar/webcast-sartorius/1698403700-1698387581-sartorius-logo-blk.png" /> </a> </div> </div> </div> <div class="col-md-6 col-sm-12 pt-1 text-end"> <a class="link-secondary" target="_blank" href="https://biospectrumasia.com/"> <img style="height:70px;" src="/bundles/interlinksapp/app/app-asia/images/logo.jpg" /> </a> </div> </div> </header> </div> <div class="border container-fluid mb-2"></div> <main class="container"> <div class="rounded"> <div class="alert alert-primary mt-3 px-0 rounded text-center"> <h4>Watch on Demand Available Now</h4> </div> </div> <div class="mb-4 rounded"> <div class="px-0 text-center rounded"> <img class="img-fluid w-100" src="/uploads/webinar/webcast-sartorius/1698403700-1698386953-Sartorius-Banner.png" /> </div> </div> <div class="row g-5"> <div class="col-md-8 mb-4"> <h6 class="fw-bold">Title</h6> <p>Robust Manufacturing of Purer AAV Gene Therapy Vectors</p> <article class="blog-post"> <h6 class="fw-bold">Abstract</h6> <p>The main goal of AAV downstream process (DSP) is to achieve high recovery of >90% full AAV capsid. For the 1<sup>st</sup> column step either affinity or cation exchange chromatography is used. For the polishing anion exchange chromatography or ultracentrifuge is employed.</p> <p>In this webinar comparison of the cation exchange and affinity column will be presented.</p> <p>To address the recent needs the new CIMmultus HR line (HR stands for High Reproducibility) columns with better resolution and narrower acceptance criteria used for the polishing step will be shown.</p> <p class="MsoNormal"><strong>Key Learning Points:</strong></p> <ul type="disc"> <li>10% improved process recovery using the strong cation exchange instead of affinity column</li> <li>up to 2 fold shorter processing time using SO3 instead of affinity column</li> <li>less damaged capsids using SO3 instead of affinity column</li> <li>>5times better resolution of the empty/full capsids by applying new methods with the QA anion exchange columns.</li> </ul> <p>The QA HR columns allow for batch-to-batch and scale-to-scale reproducibility within +/- 3%; about 10 better when compared with the traditional CIMmultus line</p> </article> <div class="speakers mb-4"> <h6 class="fw-bold">Speaker</h6> <div class="row"> <div class="col-md-3"> <img src="/uploads/webinar/webcast-sartorius/1698403700-Ales-Stancar.jpg" class="bd-placeholder-img w-100"/> </div> <div class="col-md-9"> <h6 class="fw-bold" style="color: #1b3064">Aleš Štrancar</h6> <label class="fw-bold"> Managing Director <br>Sartorius BIA Separations </label> <p style="text-align: justify"> Ales Štrancar is executive managing director of Sartorius BIA Separations since it was founded in 1998. Aleš is one of the main inventors of the CIM Convective Interaction Media® monolithic columns technology and co-inventor of many analytical methods including pDNA, mRNA, AAV, Adeno and other viruses. He co-developed a number of DSP processes including pDNA for Boehringer Ingelheim and AAV for AveXis/Novartis. Aleš is author or co-author of more than 100 scientific papers dealing with separation and purification technologies. He is a co-author of several granted patents. </p> </div> </div> </div> </div> <div class="col-md-4 mb-4"> <div class="position-sticky form-background-color" style="top: 1.5rem;"> <div class="p-3 mb-3"> <h4 class="text-center pb-3">Watch Now</h4> <div class="mb-0"> <form class="form-horizontal" name="formData" action="/webcast-sartorius" method="post" role="form"> <div class="mb-3"> <div class="col-md-12"> <input class="form-control" id="fname" placeholder="First Name *" name="formData[fname]" required="" type="text"> </div> </div> <div class="mb-3"> <div class="col-md-12"> <input class="form-control" id="lname" placeholder="Last Name *" name="formData[lname]" required="" type="text"> </div> </div> <div class="mb-3"> <div class="col-md-12"> <input class="form-control" id="designation" placeholder="Job Title *" name="formData[designation]" required="" type="text"> </div> </div> <div class="mb-3"> <div class="col-md-12"> <input class="form-control" id="organisation" placeholder="Company 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